Shantanu Sinha

Title(s)Professor In Residence, Radiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of IllinoisPostdoc RA1984Physical Chemistry
    Indian Institute of SciencePostdoc1983Solid State Physics
    Indian Institute of SciencePh.D.1983Solid State Physics
    Indian Institute of TechnologyM.Sc.1977Physics
    Indian Institute of TechnologyB.Sc.1975Physics
    Collapse Awards and Honors
    AMSSM2000Best research paper award
    American Heart Association1995Laverna Titus Young Investigator
    NCERT, New Delhi1972  - 1983National Science Talent Scholarship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Role of the Extracellular Matrix in Age-Associated Strength Loss: Combining Imaging and Biochemistry to create a Multi-Scale Mesh-free Model
    NIH R01AG056999Aug 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    In-vivo Quantification and Visualization of Intra-aneurismal Hemodynamics using Velocity Encoded MR Imaging at 3 Tesla
    General Electric Medical Systems May 1, 2007
    Role: Principal Investigator
    Description: Principal Investigator
    In Vivo Imaging-Based Multiscale Modeling of Normal and Atrophied Human Lower Leg
    NIH R01AR053343Jul 15, 2006 - Jun 30, 2017
    Role: Principal Investigator
    In-vivo MR Tractography and FEM Study of Human Lower Leg
    NIH 5R01AR053343-04Jul 15, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Impact of Morphology on Function in Normal and Atrophied Muscle -- an MR Imaging and Diffusion Tensor Tractography In vivo Study in Humans
    National Space Biomedical Research Institute/ NASA Oct 1, 2005
    Role: Principal Investigator
    Brain Tumor Therapy: Radio Surgery vs. MR-Guided Ablat;
    NIH R21CA094226Jun 1, 2004 - May 31, 2006
    Role: Principal Investigator
    In vivo Stress-Strain Dynamics in Human Muscle
    National Space Biomedical Research Institute/ NASA Oct 1, 2001
    Role: Principal Investigator
    MR Imaging Guided Laser Ablation of Nodal Metastases
    National Institute of Health/ NCI Jul 1, 1999
    Role: Co-Principal Investigator
    Accurate Quantification of Cardiac PET Data Using PET/MR Registration
    American Heart Association 1037 GI-1Jul 1, 1993
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spin Lattice (T1) and Magnetization Transfer Saturation (MTsat) Imaging to Monitor Age-Related Differences in Skeletal Muscle Tissue. Diagnostics (Basel). 2022 Feb 24; 12(3). White JC, Sinha S, Sinha U. PMID: 35328137; PMCID: PMC8947179.
      View in: PubMed   Mentions:
    2. Multiscale modeling of passive material influences on deformation and force output of skeletal muscles. Int J Numer Method Biomed Eng. 2022 Jan 20; e3571. He X, Taneja K, Chen JS, Lee CH, Hodgson J, Malis V, Sinha U, Sinha S. PMID: 35049153.
      View in: PubMed   Mentions:
    3. Dynamics of Quadriceps Muscles during Isometric Contractions: Velocity-Encoded Phase Contrast MRI Study. Diagnostics (Basel). 2021 Dec 06; 11(12). Oda T, Malis V, Finni T, Kinugasa R, Sinha S. PMID: 34943517; PMCID: PMC8699899.
      View in: PubMed   Mentions:
    4. Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle. Diagnostics (Basel). 2021 Nov 16; 11(11). Csapo R, Heinrich D, Vigotsky AD, Marx C, Sinha S, Fink C. PMID: 34829473; PMCID: PMC8622620.
      View in: PubMed   Mentions:
    5. Biomechanical Gain in Joint Excursion from the Curvature of the Achilles Tendon: Role of the Geometrical Arrangement of Inflection Point, Center of Rotation, and Calcaneus. Diagnostics (Basel). 2021 Nov 12; 11(11). Kinugasa R, Yamamura N, Takagi S, Sinha S. PMID: 34829443; PMCID: PMC8618986.
      View in: PubMed   Mentions:
    6. 3D Muscle Deformation Mapping at Submaximal Isometric Contractions: Applications to Aging Muscle. Front Physiol. 2020; 11:600590. Malis V, Sinha U, Sinha S. PMID: 33343396; PMCID: PMC7744822.
      View in: PubMed   Mentions:
    7. Role of the Extracellular Matrix in Loss of Muscle Force With Age and Unloading Using Magnetic Resonance Imaging, Biochemical Analysis, and Computational Models. Front Physiol. 2020; 11:626. Sinha U, Malis V, Chen JS, Csapo R, Kinugasa R, Narici MV, Sinha S. PMID: 32625114; PMCID: PMC7315044.
      View in: PubMed   Mentions: 3  
    8. Magnetic resonance imaging based muscle strain rate mapping during eccentric contraction to study effects of unloading induced by unilateral limb suspension. Eur J Transl Myol. 2020 Apr 07; 30(1):8935. Sinha U, Malis V, Csapo R, Narici M, Sinha S. PMID: 32499902; PMCID: PMC7254429.
      View in: PubMed   Mentions: 2  
    9. Microstructural analysis of skeletal muscle force generation during aging. Int J Numer Method Biomed Eng. 2020 01; 36(1):e3295. Zhang Y, Chen JS, He Q, He X, Basava RR, Hodgson J, Sinha U, Sinha S. PMID: 31820588; PMCID: PMC8080883.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Diffusion tensor imaging and diffusion modeling: Application to monitoring changes in the medial gastrocnemius in disuse atrophy induced by unilateral limb suspension. J Magn Reson Imaging. 2019 06; 49(6):1655-1664. Malis V, Sinha U, Csapo R, Narici M, Smitaman E, Sinha S. PMID: 30569482; PMCID: PMC6504599.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Connectivity of the Superficial Muscles of the Human Perineum: A Diffusion Tensor Imaging-Based Global Tractography Study. Sci Rep. 2018 12 14; 8(1):17867. Zifan A, Reisert M, Sinha S, Ledgerwood-Lee M, Cory E, Sah R, Mittal RK. PMID: 30552351; PMCID: PMC6294750.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Contemporary image-based methods for measuring passive mechanical properties of skeletal muscles in vivo. J Appl Physiol (1985). 2019 05 01; 126(5):1454-1464. Bilston LE, Bolsterlee B, Nordez A, Sinha S. PMID: 30236053; PMCID: PMC6589813.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Muscle Architecture Assessment: Strengths, Shortcomings and New Frontiers of in Vivo Imaging Techniques. Ultrasound Med Biol. 2018 12; 44(12):2492-2504. Franchi MV, Raiteri BJ, Longo S, Sinha S, Narici MV, Csapo R. PMID: 30185385.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    14. Shear strain rate from phase contrast velocity encoded MRI: Application to study effects of aging in the medial gastrocnemius muscle. J Magn Reson Imaging. 2018 11; 48(5):1351-1357. Sinha U, Malis V, Csapo R, Narici M, Sinha S. PMID: 29607567; PMCID: PMC6167202.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Exploration of male urethral sphincter complex using diffusion tensor imaging (DTI)-based fiber-tracking. J Magn Reson Imaging. 2018 10; 48(4):1002-1011. Sinha S, Sinha U, Malis V, Bhargava V, Sakamoto K, Rajasekaran M. PMID: 29573022; PMCID: PMC6151300.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. A Multi-modality Approach Towards Elucidation of the Mechanism for Human Achilles Tendon Bending During Passive Ankle Rotation. Sci Rep. 2018 03 12; 8(1):4319. Kinugasa R, Taniguchi K, Yamamura N, Fujimiya M, Katayose M, Takagi S, Edgerton VR, Sinha S. PMID: 29531268; PMCID: PMC5847516.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Relationship of changes in strain rate indices estimated from velocity-encoded MR imaging to loss of muscle force following disuse atrophy. Magn Reson Med. 2018 02; 79(2):912-922. Malis V, Sinha U, Csapo R, Narici M, Sinha S. PMID: 28560822; PMCID: PMC5709278.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    18. Influence of intramuscular fiber orientation on the Achilles tendon curvature using three-dimensional finite element modeling of contracting skeletal muscle. J Biomech. 2016 10 03; 49(14):3592-3595. Kinugasa R, Yamamura N, Sinha S, Takagi S. PMID: 27663620.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. 3D multimodal spatial fuzzy segmentation of intramuscular connective and adipose tissue from ultrashort TE MR images of calf muscle. Magn Reson Med. 2017 02; 77(2):870-883. Ugarte V, Sinha U, Malis V, Csapo R, Sinha S. PMID: 26892499; PMCID: PMC4991958.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Mapping of spatial and temporal heterogeneity of plantar flexor muscle activity during isometric contraction: correlation of velocity-encoded MRI with EMG. J Appl Physiol (1985). 2015 Sep 01; 119(5):558-68. Csapo R, Malis V, Sinha U, Sinha S. PMID: 26112239; PMCID: PMC4556836.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Pixel-based meshfree modelling of skeletal muscles. Comput Methods Biomech Biomed Eng Imaging Vis. 2016; 4(2):73-85. Chen JS, Basava RR, Zhang Y, Csapo R, Malis V, Sinha U, Hodgson J, Sinha S. PMID: 28748126; PMCID: PMC5523135.
      View in: PubMed   Mentions: 2  
    22. Age-related differences in strain rate tensor of the medial gastrocnemius muscle during passive plantarflexion and active isometric contraction using velocity encoded MR imaging: potential index of lateral force transmission. Magn Reson Med. 2015 May; 73(5):1852-63. Sinha U, Malis V, Csapo R, Moghadasi A, Kinugasa R, Sinha S. PMID: 25046255; PMCID: PMC4287463.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    23. Age-associated differences in triceps surae muscle composition and strength - an MRI-based cross-sectional comparison of contractile, adipose and connective tissue. BMC Musculoskelet Disord. 2014 Jun 17; 15:209. Csapo R, Malis V, Sinha U, Du J, Sinha S. PMID: 24939372; PMCID: PMC4072482.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    24. Age-related differences in diffusion tensor indices and fiber architecture in the medial and lateral gastrocnemius. J Magn Reson Imaging. 2015 Apr; 41(4):941-53. Sinha U, Csapo R, Malis V, Xue Y, Sinha S. PMID: 24771672; PMCID: PMC4212021.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    25. Purse-string morphology of external anal sphincter revealed by novel imaging techniques. Am J Physiol Gastrointest Liver Physiol. 2014 Mar; 306(6):G505-14. Mittal RK, Bhargava V, Sheean G, Ledgerwood M, Sinha S. PMID: 24458022; PMCID: PMC3949029.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    26. Interaponeurosis shear strain modulates behavior of myotendinous junction of the human triceps surae. Physiol Rep. 2013 Nov; 1(6):e00147. Kinugasa R, Oda T, Komatsu T, Edgerton VR, Sinha S. PMID: 24400149; PMCID: PMC3871462.
      View in: PubMed   Mentions: 2     Fields:    
    27. Ankle morphology amplifies calcaneus movement relative to triceps surae muscle shortening. J Appl Physiol (1985). 2013 Aug 15; 115(4):468-73. Csapo R, Hodgson J, Kinugasa R, Edgerton VR, Sinha S. PMID: 23743400; PMCID: PMC3742942.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. Computer-controlled, MR-compatible foot-pedal device to study dynamics of the muscle tendon complex under isometric, concentric, and eccentric contractions. J Magn Reson Imaging. 2012 Aug; 36(2):498-504. Sinha S, Shin DD, Hodgson JA, Kinugasa R, Edgerton VR. PMID: 22392816; PMCID: PMC3984931.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    29. Finite element modeling of passive material influence on the deformation and force output of skeletal muscle. J Mech Behav Biomed Mater. 2012 May; 9:163-83. Hodgson JA, Chi SW, Yang JP, Chen JS, Edgerton VR, Sinha S. PMID: 22498294; PMCID: PMC4075494.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    30. Asymmetric deformation of contracting human gastrocnemius muscle. J Appl Physiol (1985). 2012 Feb; 112(3):463-70. Kinugasa R, Hodgson JA, Edgerton VR, Sinha S. PMID: 22134691; PMCID: PMC3289422.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. Unique spatial distribution of in vivo human muscle activation. Exp Physiol. 2011 Sep; 96(9):938-48. Kinugasa R, Kawakami Y, Sinha S, Fukunaga T. PMID: 21666032.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    32. Reproducibility analysis of diffusion tensor indices and fiber architecture of human calf muscles in vivo at 1.5 Tesla in neutral and plantarflexed ankle positions at rest. J Magn Reson Imaging. 2011 Jul; 34(1):107-19. Sinha S, Sinha U. PMID: 21608064; PMCID: PMC3121919.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    33. Human soleus muscle architecture at different ankle joint angles from magnetic resonance diffusion tensor imaging. J Appl Physiol (1985). 2011 Mar; 110(3):807-19. Sinha U, Sinha S, Hodgson JA, Edgerton RV. PMID: 21164150; PMCID: PMC3069630.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    34. Reduction in tendon elasticity from unloading is unrelated to its hypertrophy. J Appl Physiol (1985). 2010 Sep; 109(3):870-7. Kinugasa R, Hodgson JA, Edgerton VR, Shin DD, Sinha S. PMID: 20616227; PMCID: PMC2944640.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. Finite element modeling reveals complex strain mechanics in the aponeuroses of contracting skeletal muscle. J Biomech. 2010 May 07; 43(7):1243-50. Chi SW, Hodgson J, Chen JS, Reggie Edgerton V, Shin DD, Roiz RA, Sinha S. PMID: 20189180; PMCID: PMC2857665.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    36. In vivo intramuscular fascicle-aponeuroses dynamics of the human medial gastrocnemius during plantarflexion and dorsiflexion of the foot. J Appl Physiol (1985). 2009 Oct; 107(4):1276-84. Shin DD, Hodgson JA, Edgerton VR, Sinha S. PMID: 19608924; PMCID: PMC2763833.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    37. Recent advances in breast MRI and MRS. NMR Biomed. 2009 Jan; 22(1):3-16. Sinha S, Sinha U. PMID: 18654998.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    38. In vivo estimation and repeatability of force-length relationship and stiffness of the human achilles tendon using phase contrast MRI. J Magn Reson Imaging. 2008 Oct; 28(4):1039-45. Shin D, Finni T, Ahn S, Hodgson JA, Lee HD, Edgerton VR, Sinha S. PMID: 18821605; PMCID: PMC2907260.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. Phase-contrast MRI reveals mechanical behavior of superficial and deep aponeuroses in human medial gastrocnemius during isometric contraction. J Appl Physiol (1985). 2008 Oct; 105(4):1312-20. Kinugasa R, Shin D, Yamauchi J, Mishra C, Hodgson JA, Edgerton VR, Sinha S. PMID: 18703759; PMCID: PMC2576031.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    40. Effect of chronic unloading and rehabilitation on human Achilles tendon properties: a velocity-encoded phase-contrast MRI study. J Appl Physiol (1985). 2008 Oct; 105(4):1179-86. Shin D, Finni T, Ahn S, Hodgson JA, Lee HD, Edgerton VR, Sinha S. PMID: 18687975; PMCID: PMC2576038.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    41. Thigh muscle function in stroke patients revealed by velocity-encoded cine phase-contrast magnetic resonance imaging. Muscle Nerve. 2008 Jun; 37(6):736-44. Wen H, Dou Z, Finni T, Havu M, Kang Z, Cheng S, Sipilä S, Sinha S, Usenius JP, Cheng S. PMID: 18335468.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Mechanical behavior of the quadriceps femoris muscle tendon unit during low-load contractions. J Appl Physiol (1985). 2008 May; 104(5):1320-8. Finni T, Havu M, Sinha S, Usenius JP, Cheng S. PMID: 18339890.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Fluid-induced wall shear stress in anthropomorphic brain aneurysm models: MR phase-contrast study at 3 T. J Magn Reson Imaging. 2007 Jun; 25(6):1120-30. Ahn S, Shin D, Tateshima S, Tanishita K, Vinuela F, Sinha S. PMID: 17520716.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    44. In vivo diffusion tensor imaging of the human calf muscle. J Magn Reson Imaging. 2006 Jul; 24(1):182-90. Sinha S, Sinha U, Edgerton VR. PMID: 16729262.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    45. Left ventricular papillary muscle mass: relationship to left ventricular mass and volumes by magnetic resonance imaging. J Comput Assist Tomogr. 2006 May-Jun; 30(3):426-32. Vogel-Claussen J, Finn JP, Gomes AS, Hundley GW, Jerosch-Herold M, Pearson G, Sinha S, Lima JA, Bluemke DA. PMID: 16778617.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    46. Influence of structure on the tissue dynamics of the human soleus muscle observed in MRI studies during isometric contractions. J Morphol. 2006 May; 267(5):584-601. Hodgson JA, Finni T, Lai AM, Edgerton VR, Sinha S. PMID: 16453292.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    47. Soleus aponeurosis strain distribution following chronic unloading in humans: an in vivo MR phase-contrast study. J Appl Physiol (1985). 2006 Jun; 100(6):2004-11. Lee HD, Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. PMID: 16424072.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    48. Muscle synergism during isometric plantarflexion in achilles tendon rupture patients and in normal subjects revealed by velocity-encoded cine phase-contrast MRI. Clin Biomech (Bristol, Avon). 2006 Jan; 21(1):67-74. Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. PMID: 16194588.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    49. Muscle kinematics during isometric contraction: development of phase contrast and spin tag techniques to study healthy and atrophied muscles. J Magn Reson Imaging. 2004 Dec; 20(6):1008-19. Sinha S, Hodgson JA, Finni T, Lai AM, Grinstead J, Edgerton VR. PMID: 15558560.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    50. In vivo diffusion tensor imaging of the human prostate. Magn Reson Med. 2004 Sep; 52(3):530-7. Sinha S, Sinha U. PMID: 15334571.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    51. Mapping of movement in the isometrically contracting human soleus muscle reveals details of its structural and functional complexity. J Appl Physiol (1985). 2003 Nov; 95(5):2128-33. Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. PMID: 12857769.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    52. Nonuniform strain of human soleus aponeurosis-tendon complex during submaximal voluntary contractions in vivo. J Appl Physiol (1985). 2003 Aug; 95(2):829-37. Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. PMID: 12716873.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    53. Functional magnetic resonance of human breast tumors: diffusion and perfusion imaging. Ann N Y Acad Sci. 2002 Dec; 980:95-115. Sinha S, Sinha U. PMID: 12594084.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    54. In vivo diffusion-weighted MRI of the breast: potential for lesion characterization. J Magn Reson Imaging. 2002 Jun; 15(6):693-704. Sinha S, Lucas-Quesada FA, Sinha U, DeBruhl N, Bassett LW. PMID: 12112520.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
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