Shantanu Sinha

Title(s)Professor In Residence, Radiology
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    University of IllinoisPostdoc RA1984Physical Chemistry
    Indian Institute of SciencePostdoc1983Solid State Physics
    Indian Institute of SciencePh.D.1983Solid State Physics
    Indian Institute of TechnologyM.Sc.1977Physics
    Indian Institute of TechnologyB.Sc.1975Physics
    Collapse Awards and Honors
    AMSSM2000Best research paper award
    American Heart Association1995Laverna Titus Young Investigator
    NCERT, New Delhi1972  - 1983National Science Talent Scholarship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Role of the Extracellular Matrix in Age-Associated Strength Loss: Combining Imaging and Biochemistry to create a Multi-Scale Mesh-free Model
    NIH/NIA R01AG056999Aug 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    In Vivo Imaging-Based Multiscale Modeling of Normal and Atrophied Human Lower Leg
    NIH/NIAMS R01AR053343Jul 15, 2006 - Jun 30, 2015
    Role: Principal Investigator
    NIH U41RR019703Sep 29, 2005 - Jul 31, 2010
    Role: Co-Investigator
    Brain Tumor Therapy: Radio Surgery vs. MR-Guided Ablat;
    NIH/NCI R21CA094226Jun 1, 2004 - May 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Malis V, Sinha U, Csapo R, Narici M, Smitaman E, Sinha S. Diffusion tensor imaging and diffusion modeling: Application to monitoring changes in the medial gastrocnemius in disuse atrophy induced by unilateral limb suspension. J Magn Reson Imaging. 2018 Dec 19. PMID: 30569482.
      View in: PubMed
    2. Zifan A, Reisert M, Sinha S, Ledgerwood-Lee M, Cory E, Sah R, Mittal RK. Connectivity of the Superficial Muscles of the Human Perineum: A Diffusion Tensor Imaging-Based Global Tractography Study. Sci Rep. 2018 Dec 14; 8(1):17867. PMID: 30552351.
      View in: PubMed
    3. Bilston LE, Bolsterlee B, Nordez A, Sinha S. Contemporary image-based methods for measuring passive mechanical properties of skeletal muscles in vivo. J Appl Physiol (1985). 2018 Sep 20. PMID: 30236053.
      View in: PubMed
    4. Franchi MV, Raiteri BJ, Longo S, Sinha S, Narici MV, Csapo R. Muscle Architecture Assessment: Strengths, Shortcomings and New Frontiers of in Vivo Imaging Techniques. Ultrasound Med Biol. 2018 12; 44(12):2492-2504. PMID: 30185385.
      View in: PubMed
    5. Sinha U, Malis V, Csapo R, Narici M, Sinha S. Shear strain rate from phase contrast velocity encoded MRI: Application to study effects of aging in the medial gastrocnemius muscle. J Magn Reson Imaging. 2018 Nov; 48(5):1351-1357. PMID: 29607567.
      View in: PubMed
    6. Sinha S, Sinha U, Malis V, Bhargava V, Sakamoto K, Rajasekaran M. Exploration of male urethral sphincter complex using diffusion tensor imaging (DTI)-based fiber-tracking. J Magn Reson Imaging. 2018 Oct; 48(4):1002-1011. PMID: 29573022.
      View in: PubMed
    7. Kinugasa R, Taniguchi K, Yamamura N, Fujimiya M, Katayose M, Takagi S, Edgerton VR, Sinha S. A Multi-modality Approach Towards Elucidation of the Mechanism for Human Achilles Tendon Bending During Passive Ankle Rotation. Sci Rep. 2018 Mar 12; 8(1):4319. PMID: 29531268.
      View in: PubMed
    8. Malis V, Sinha U, Csapo R, Narici M, Sinha S. Relationship of changes in strain rate indices estimated from velocity-encoded MR imaging to loss of muscle force following disuse atrophy. Magn Reson Med. 2018 02; 79(2):912-922. PMID: 28560822.
      View in: PubMed
    9. Kinugasa R, Yamamura N, Sinha S, Takagi S. Influence of intramuscular fiber orientation on the Achilles tendon curvature using three-dimensional finite element modeling of contracting skeletal muscle. J Biomech. 2016 10 03; 49(14):3592-3595. PMID: 27663620.
      View in: PubMed
    10. Ugarte V, Sinha U, Malis V, Csapo R, Sinha S. 3D multimodal spatial fuzzy segmentation of intramuscular connective and adipose tissue from ultrashort TE MR images of calf muscle. Magn Reson Med. 2017 02; 77(2):870-883. PMID: 26892499.
      View in: PubMed
    11. Csapo R, Malis V, Sinha U, Sinha S. Mapping of spatial and temporal heterogeneity of plantar flexor muscle activity during isometric contraction: correlation of velocity-encoded MRI with EMG. J Appl Physiol (1985). 2015 Sep 01; 119(5):558-68. PMID: 26112239; PMCID: PMC4556836.
    12. Chen JS, Basava RR, Zhang Y, Csapo R, Malis V, Sinha U, Hodgson J, Sinha S. Pixel-based meshfree modelling of skeletal muscles. Comput Methods Biomech Biomed Eng Imaging Vis. 2016; 4(2):73-85. PMID: 28748126.
      View in: PubMed
    13. Sinha U, Malis V, Csapo R, Moghadasi A, Kinugasa R, Sinha S. Age-related differences in strain rate tensor of the medial gastrocnemius muscle during passive plantarflexion and active isometric contraction using velocity encoded MR imaging: potential index of lateral force transmission. Magn Reson Med. 2015 May; 73(5):1852-63. PMID: 25046255; PMCID: PMC4287463.
    14. Rajasekaran MR, Sinha S, Seo Y, Salehi M, Bhargava V, Mittal RK. Myoarchitectural and functional alterations in rabbit external anal sphincter muscle following experimental surgical trauma. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15; 307(4):G445-51. PMID: 24994856.
      View in: PubMed
    15. Csapo R, Malis V, Sinha U, Du J, Sinha S. Age-associated differences in triceps surae muscle composition and strength - an MRI-based cross-sectional comparison of contractile, adipose and connective tissue. BMC Musculoskelet Disord. 2014 Jun 17; 15:209. PMID: 24939372; PMCID: PMC4072482.
    16. Sinha U, Csapo R, Malis V, Xue Y, Sinha S. Age-related differences in diffusion tensor indices and fiber architecture in the medial and lateral gastrocnemius. J Magn Reson Imaging. 2015 Apr; 41(4):941-53. PMID: 24771672; PMCID: PMC4212021.
    17. Mittal RK, Bhargava V, Sheean G, Ledgerwood M, Sinha S. Purse-string morphology of external anal sphincter revealed by novel imaging techniques. Am J Physiol Gastrointest Liver Physiol. 2014 Mar; 306(6):G505-14. PMID: 24458022; PMCID: PMC3949029.
    18. Kinugasa R, Oda T, Komatsu T, Edgerton VR, Sinha S. Interaponeurosis shear strain modulates behavior of myotendinous junction of the human triceps surae. Physiol Rep. 2013 Nov; 1(6):e00147. PMID: 24400149; PMCID: PMC3871462.
    19. Csapo R, Hodgson J, Kinugasa R, Edgerton VR, Sinha S. Ankle morphology amplifies calcaneus movement relative to triceps surae muscle shortening. J Appl Physiol (1985). 2013 Aug 15; 115(4):468-73. PMID: 23743400; PMCID: PMC3742942.
    20. Sinha S, Shin DD, Hodgson JA, Kinugasa R, Edgerton VR. Computer-controlled, MR-compatible foot-pedal device to study dynamics of the muscle tendon complex under isometric, concentric, and eccentric contractions. J Magn Reson Imaging. 2012 Aug; 36(2):498-504. PMID: 22392816; PMCID: PMC3984931.
    21. Hodgson JA, Chi SW, Yang JP, Chen JS, Edgerton VR, Sinha S. Finite element modeling of passive material influence on the deformation and force output of skeletal muscle. J Mech Behav Biomed Mater. 2012 May; 9:163-83. PMID: 22498294; PMCID: PMC4075494.
    22. Kinugasa R, Hodgson JA, Edgerton VR, Sinha S. Asymmetric deformation of contracting human gastrocnemius muscle. J Appl Physiol (1985). 2012 Feb; 112(3):463-70. PMID: 22134691; PMCID: PMC3289422.
    23. Kinugasa R, Kawakami Y, Sinha S, Fukunaga T. Unique spatial distribution of in vivo human muscle activation. Exp Physiol. 2011 Sep; 96(9):938-48. PMID: 21666032.
      View in: PubMed
    24. Sinha S, Sinha U. Reproducibility analysis of diffusion tensor indices and fiber architecture of human calf muscles in vivo at 1.5 Tesla in neutral and plantarflexed ankle positions at rest. J Magn Reson Imaging. 2011 Jul; 34(1):107-19. PMID: 21608064; PMCID: PMC3121919.
    25. Sinha U, Sinha S, Hodgson JA, Edgerton RV. Human soleus muscle architecture at different ankle joint angles from magnetic resonance diffusion tensor imaging. J Appl Physiol (1985). 2011 Mar; 110(3):807-19. PMID: 21164150; PMCID: PMC3069630.
    26. Kinugasa R, Hodgson JA, Edgerton VR, Shin DD, Sinha S. Reduction in tendon elasticity from unloading is unrelated to its hypertrophy. J Appl Physiol (1985). 2010 Sep; 109(3):870-7. PMID: 20616227; PMCID: PMC2944640.
    27. Chi SW, Hodgson J, Chen JS, Reggie Edgerton V, Shin DD, Roiz RA, Sinha S. Finite element modeling reveals complex strain mechanics in the aponeuroses of contracting skeletal muscle. J Biomech. 2010 May 07; 43(7):1243-50. PMID: 20189180; PMCID: PMC2857665.
    28. Shin DD, Hodgson JA, Edgerton VR, Sinha S. In vivo intramuscular fascicle-aponeuroses dynamics of the human medial gastrocnemius during plantarflexion and dorsiflexion of the foot. J Appl Physiol (1985). 2009 Oct; 107(4):1276-84. PMID: 19608924; PMCID: PMC2763833.
    29. Sinha S, Sinha U. Recent advances in breast MRI and MRS. NMR Biomed. 2009 Jan; 22(1):3-16. PMID: 18654998.
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    30. Shin D, Finni T, Ahn S, Hodgson JA, Lee HD, Edgerton VR, Sinha S. In vivo estimation and repeatability of force-length relationship and stiffness of the human achilles tendon using phase contrast MRI. J Magn Reson Imaging. 2008 Oct; 28(4):1039-45. PMID: 18821605; PMCID: PMC2907260.
    31. Kinugasa R, Shin D, Yamauchi J, Mishra C, Hodgson JA, Edgerton VR, Sinha S. Phase-contrast MRI reveals mechanical behavior of superficial and deep aponeuroses in human medial gastrocnemius during isometric contraction. J Appl Physiol (1985). 2008 Oct; 105(4):1312-20. PMID: 18703759; PMCID: PMC2576031.
    32. Shin D, Finni T, Ahn S, Hodgson JA, Lee HD, Edgerton VR, Sinha S. Effect of chronic unloading and rehabilitation on human Achilles tendon properties: a velocity-encoded phase-contrast MRI study. J Appl Physiol (1985). 2008 Oct; 105(4):1179-86. PMID: 18687975; PMCID: PMC2576038.
    33. Wen H, Dou Z, Finni T, Havu M, Kang Z, Cheng S, Sipilä S, Sinha S, Usenius JP, Cheng S. Thigh muscle function in stroke patients revealed by velocity-encoded cine phase-contrast magnetic resonance imaging. Muscle Nerve. 2008 Jun; 37(6):736-44. PMID: 18335468.
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    34. Finni T, Havu M, Sinha S, Usenius JP, Cheng S. Mechanical behavior of the quadriceps femoris muscle tendon unit during low-load contractions. J Appl Physiol (1985). 2008 May; 104(5):1320-8. PMID: 18339890.
      View in: PubMed
    35. Ahn S, Shin D, Tateshima S, Tanishita K, Vinuela F, Sinha S. Fluid-induced wall shear stress in anthropomorphic brain aneurysm models: MR phase-contrast study at 3 T. J Magn Reson Imaging. 2007 Jun; 25(6):1120-30. PMID: 17520716.
      View in: PubMed
    36. Sinha S, Sinha U, Edgerton VR. In vivo diffusion tensor imaging of the human calf muscle. J Magn Reson Imaging. 2006 Jul; 24(1):182-90. PMID: 16729262.
      View in: PubMed
    37. Vogel-Claussen J, Finn JP, Gomes AS, Hundley GW, Jerosch-Herold M, Pearson G, Sinha S, Lima JA, Bluemke DA. Left ventricular papillary muscle mass: relationship to left ventricular mass and volumes by magnetic resonance imaging. J Comput Assist Tomogr. 2006 May-Jun; 30(3):426-32. PMID: 16778617.
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    38. Hodgson JA, Finni T, Lai AM, Edgerton VR, Sinha S. Influence of structure on the tissue dynamics of the human soleus muscle observed in MRI studies during isometric contractions. J Morphol. 2006 May; 267(5):584-601. PMID: 16453292.
      View in: PubMed
    39. Grinstead JW, Sinha S, Tateshima S, Nien YL, Vinuela F. Visualization and quantification of flow and velocity fields in intracranial arteriovenous malformations using phase-contrast MR angiography. AJR Am J Roentgenol. 2006 Feb; 186(2):553-5. PMID: 16423967.
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    40. Lee HD, Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. Soleus aponeurosis strain distribution following chronic unloading in humans: an in vivo MR phase-contrast study. J Appl Physiol (1985). 2006 Jun; 100(6):2004-11. PMID: 16424072.
      View in: PubMed
    41. Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. Muscle synergism during isometric plantarflexion in achilles tendon rupture patients and in normal subjects revealed by velocity-encoded cine phase-contrast MRI. Clin Biomech (Bristol, Avon). 2006 Jan; 21(1):67-74. PMID: 16194588.
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    42. Grinstead J, Sinha S. In-plane velocity encoding with coherent steady-state imaging. Magn Reson Med. 2005 Jul; 54(1):138-45. PMID: 15968674.
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    43. Bhidayasiri R, Bronstein JM, Sinha S, Krahl SE, Ahn S, Behnke EJ, Cohen MS, Frysinger R, Shellock FG. Bilateral neurostimulation systems used for deep brain stimulation: in vitro study of MRI-related heating at 1.5 T and implications for clinical imaging of the brain. Magn Reson Imaging. 2005 May; 23(4):549-55. PMID: 15919600.
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    44. Sinha S, Hodgson JA, Finni T, Lai AM, Grinstead J, Edgerton VR. Muscle kinematics during isometric contraction: development of phase contrast and spin tag techniques to study healthy and atrophied muscles. J Magn Reson Imaging. 2004 Dec; 20(6):1008-19. PMID: 15558560.
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    45. Sinha S, Sinha U. In vivo diffusion tensor imaging of the human prostate. Magn Reson Med. 2004 Sep; 52(3):530-7. PMID: 15334571.
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    46. Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. Mapping of movement in the isometrically contracting human soleus muscle reveals details of its structural and functional complexity. J Appl Physiol (1985). 2003 Nov; 95(5):2128-33. PMID: 12857769.
      View in: PubMed
    47. Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. Nonuniform strain of human soleus aponeurosis-tendon complex during submaximal voluntary contractions in vivo. J Appl Physiol (1985). 2003 Aug; 95(2):829-37. PMID: 12716873.
      View in: PubMed
    48. Sinha S, Sinha U. Functional magnetic resonance of human breast tumors: diffusion and perfusion imaging. Ann N Y Acad Sci. 2002 Dec; 980:95-115. PMID: 12594084.
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    49. Sinha S, Lucas-Quesada FA, Sinha U, DeBruhl N, Bassett LW. In vivo diffusion-weighted MRI of the breast: potential for lesion characterization. J Magn Reson Imaging. 2002 Jun; 15(6):693-704. PMID: 12112520.
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