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    Pedro Cabrales Arevalo

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-534-8197
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zimmerman R, Tsai AG, Salazar Vázquez BY, Cabrales P, Hofmann A, Meier J, Shander A, Spahn DR, Friedman JM, Tartakovsky DM, Intaglietta M. Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity. Anesth Analg. 2017 May; 124(5):1547-1554. PMID: 28328758.
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      2. Cabrales P, Caroen S, Oronsky A, Carter C, Trepel J, Summers T, Reid T, Oronsky N, Lybeck M, Oronsky B. The macrophage stimulating anti-cancer agent, RRx-001, protects against ischemia-reperfusion injury. Expert Rev Hematol. 2017 Apr 27. PMID: 28448172.
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      3. Oronsky B, Reid TR, Larson C, Carter CA, Brzezniak CE, Oronsky A, Cabrales P. RRx-001 protects against cisplatin-induced toxicities. J Cancer Res Clin Oncol. 2017 Apr 17. PMID: 28417195.
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      4. Jani VP, Jelvani A, Moges S, Nacharaju P, Roche C, Dantsker D, Palmer A, Friedman JM, Cabrales P. Polyethylene Glycol Camouflaged Earthworm Hemoglobin. PLoS One. 2017; 12(1):e0170041. PMID: 28099525.
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      5. Oronsky B, Paulmurugan R, Foygel K, Scicinski J, Knox SJ, Peehl D, Zhao H, Ning S, Cabrales P, Summers TA, Reid TR, Fitch WL, Kim MM, Trepel JB, Lee MJ, Kesari S, Abrouk ND, Day RM, Oronsky A, Ray CM, Carter CA. RRx-001: A Systemically Non-Toxic M2-to-M1 Macrophage Stimulating and Prosensitizing Agent In Phase II Clinical Trials. Expert Opin Investig Drugs. 2016 Dec 09. PMID: 27935336.
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      6. Ao-Ieong ES, Williams A, Jani V, Cabrales P. Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic. Artif Cells Nanomed Biotechnol. 2017 Jun; 45(4):686-693. PMID: 27881020.
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      7. Azad P, Zhao HW, Cabrales PJ, Ronen R, Zhou D, Poulsen O, Appenzeller O, Hsiao YH, Bafna V, Haddad GG. Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med. 2016 Nov 14; 213(12):2729-2744. PMID: 27821551.
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      8. Oronsky B, Caroen S, Zeman K, Quinn M, Brzezniak C, Scicinski J, Cabrales P, Reid TR, Trepel JB, Abrouk ND, Larson C, Oronsky A, Lybeck HE, Day RM, Carter CA. A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001. Clin Med Insights Oncol. 2016; 10:105-108. PMID: 27840583.
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      9. Martucci AF, Abreu Martucci AC, Cabrales P, Nascimento PD, Intaglietta M, Tsai AG, Castiglia YM. Acute kidney function and morphology following topload administration of recombinant hemoglobin solution. Artif Cells Nanomed Biotechnol. 2016 Oct 31; 1-7. PMID: 27797281.
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      10. Brzezniak C, Oronsky B, Scicinski J, Caroen S, Cabrales P, Dean Abrouk N, Kim MM, Brown JF, Reid TR, Larson C, Oronsky A, Day R, Degesys A, Carter CA. Conversion of Platinum-Etoposide-Resistant to Sensitive SCLC after Treatment with the Epi-Immunotherapeutic RRx-001: A Case Report. Oncol Res Treat. 2016; 39(11):720-723. PMID: 27855386.
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      11. Buono MJ, Cabrales P. Hyperthermia during exercise - a double-edged sword. Temperature (Austin). 2016; 3(4):512-513. PMID: 28090552.
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      12. Oronsky B, Scicinski J, Kim MM, Cabrales P, Salacz ME, Carter CA, Oronsky N, Lybeck H, Lybeck M, Larson C, Reid TR, Oronsky A. Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents. Biomolecules. 2016 Jul 04; 6(3). PMID: 27384589.
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      13. Fens MH, Cabrales P, Scicinski J, Larkin SK, Suh JH, Kuypers FA, Oronsky N, Lybeck M, Oronsky A, Oronsky B. Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation. Med Oncol. 2016 Aug; 33(8):85. PMID: 27377482.
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      14. Díaz-Trelles R, Scimia MC, Bushway P, Tran D, Monosov A, Monosov E, Peterson K, Rentschler S, Cabrales P, Ruiz-Lozano P, Mercola M. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun. 2016; 7:12088. PMID: 27357444.
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      15. Cabrales P, Scicinski J, Reid T, Kuypers F, Larkin S, Fens M, Oronsky A, Oronsky B. A look inside the mechanistic black box: Are red blood cells the critical effectors of RRx-001 cytotoxicity? Med Oncol. 2016 Jul; 33(7):63. PMID: 27229330.
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      16. Carter CA, Oronsky B, Caroen S, Scicinski J, Degesys A, Cabrales P, Reid TR, Brzezniak C. Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets. Case Rep Oncol. 2016 May-Aug; 9(2):285-9. PMID: 27403127.
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      17. Oronsky B, Scicinski J, Cabrales P, Minchinton A. RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors. Clin Epigenetics. 2016; 8:53. PMID: 27175220; PMCID: PMC4864927.
      18. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 1; 291(27):14274-84. PMID: 27189937.
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      19. Damestani Y, Galan-Hoffman DE, Ortiz D, Cabrales P, Aguilar G. Inflammatory response to implantation of transparent nanocrystalline yttria-stabilized zirconia using a dorsal window chamber model. Nanomedicine. 2016 Oct; 12(7):1757-1763. PMID: 27133190.
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      20. Carter CA, Oronsky B, Caroen S, Scicinski J, Cabrales P, Degesys A, Brzezniak C. Partial response to carboplatin in an RRx-001 pretreated patient with EGFR-inhibitor-resistance and T790M-negative NSCLC. Respir Med Case Rep. 2016; 18:62-5. PMID: 27330954; PMCID: PMC4913156.
      21. Oronsky B, Scicinski J, Reid T, Oronsky A, Carter C, Oronsky N, Cabrales P. RRx-001, a novel clinical-stage chemosensitizer, radiosensitizer, and immunosensitizer, inhibits glucose 6-phosphate dehydrogenase in human tumor cells. Discov Med. 2016 Apr; 21(116):251-65. PMID: 27232511.
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      22. Carter CA, Oronsky BT, Caroen SZ, Scicinski JJ, Degesys A, Kim MM, Oronsky AL, Lybeck H, Cabrales P, Oronsky N, Reid T, Roswarski J, Brzezniak C. RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets. Case Rep Oncol. 2016 Jan-Apr; 9(1):171-6. PMID: 27065849; PMCID: PMC4821137.
      23. Carter CA, Schmitz B, Peterson PG, Quinn M, Degesys A, Jenkins J, Oronsky B, Scicinski J, Caroen S, Reid TR, Cabrales P, Brzezniak C. Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001. Case Rep Oncol. 2016 Jan-Apr; 9(1):164-70. PMID: 27065848.
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      24. Oronsky B, Scicinski J, Ning S, Peehl D, Oronsky A, Cabrales P, Bednarski M, Knox S. Rockets, radiosensitizers, and RRx-001: an origin story part I. Discov Med. 2016 Mar; 21(115):173-80. PMID: 27115167.
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      25. Oronsky B, Scicinski J, Ning S, Peehl D, Oronsky A, Cabrales P, Bednarski M, Knox S. RRx-001, A novel dinitroazetidine radiosensitizer. Invest New Drugs. 2016 Feb 3. PMID: 26841903.
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      26. Buono MJ, Krippes T, Kolkhorst FW, Williams AT, Cabrales P. Increases in core temperature counterbalance effects of haemoconcentration on blood viscosity during prolonged exercise in the heat. Exp Physiol. 2016 Feb 1; 101(2):332-42. PMID: 26682653; NIHMSID: NIHMS746230 [Available on 02/01/17].
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      27. Carter CA, Oronsky BT, Caroen SZ, Scicinski JJ, Cabrales P, Reid T, Degesys A, Jenkins J, Brzezniak C. Partial Response to Platinum Doublets in Refractory EGFR-Positive Non-Small Cell Lung Cancer Patients after RRx-001: Evidence of Episensitization. Case Rep Oncol. 2016 Jan-Apr; 9(1):62-7. PMID: 26933421; PMCID: PMC4772628.
      28. Salazar Vázquez BY, Salazar Vázquez MA, López Gutiérrez G, Acosta Rosales K, Cabrales P, Vadillo-Ortega F, Intaglietta M, Pérez Tamayo R, Schmid-Schönbein GW. Control of overweight and obesity in childhood through education in meal time habits. The 'good manners for a healthy future' programme. Pediatr Obes. 2015 Dec 15. PMID: 26667210.
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      29. Kar M, Vernon Shih YR, Velez DO, Cabrales P, Varghese S. Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery. Biomaterials. 2016 Jan; 77:186-97. PMID: 26606444.
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      30. Carter CA, Degesys A, Oronsky B, Scicinski J, Caroen SZ, Oronsky AL, Reid T, Cabrales P, Roswarski J. Flushing Out Carcinoid Syndrome: Beneficial Effect of the Anticancer Epigenetic Agent RRx-001 in a Patient with a Treatment-Refractory Neuroendocrine Tumor. Case Rep Oncol. 2015 Sep-Dec; 8(3):461-5. PMID: 26600780; PMCID: PMC4649750.
      31. Reid T, Oronsky B, Scicinski J, Scribner CL, Knox SJ, Ning S, Peehl DM, Korn R, Stirn M, Carter CA, Oronsky A, Taylor MJ, Fitch WL, Cabrales P, Kim MM, Burris HA, Lao CD, Abrouk NE, Fanger GR, Infante JR. Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study. Lancet Oncol. 2015 Sep; 16(9):1133-42. PMID: 26296952.
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      32. Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG. Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10425-30. PMID: 26240367.
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      33. Anandan P, Ortiz D, Intaglietta M, Cabrales PJ, Bucolo M. Red blood cells flows in rectilinear microfluidic chip. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:3225-8. PMID: 26736979.
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      34. Yalcin O, Ortiz D, Williams AT, Johnson PC, Cabrales P. Perfusion pressure and blood flow determine microvascular apparent viscosity. Exp Physiol. 2015 Aug; 100(8):977-87. PMID: 26011432.
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      35. Yalcin O, Oronsky B, Carvalho LJ, Kuypers FA, Scicinski J, Cabrales P. From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria. Malar J. 2015; 14:218. PMID: 26017006; PMCID: PMC4453052.
      36. Cabrales P, Ortiz D, Friedman JM. NO supplementation for transfusion medicine and cardiovascular applications. Future Sci OA. 2015; 1(1). PMID: 26807267.
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      37. Brouse C, Ortiz D, Su Y, Oronsky B, Scicinski J, Cabrales P. Impact of hemoglobin nitrite to nitric oxide reductase on blood transfusion for resuscitation from hemorrhagic shock. Asian J Transfus Sci. 2015 Jan-Jun; 9(1):55-60. PMID: 25722574; PMCID: PMC4339933.
      38. Mooij HL, Cabrales P, Bernelot Moens SJ, Xu D, Udayappan SD, Tsai AG, van der Sande MA, de Groot E, Intaglietta M, Kastelein JJ, Dallinga-Thie GM, Esko JD, Stroes ES, Nieuwdorp M. Loss of Function in Heparan Sulfate Elongation Genes EXT1 and EXT 2 Results in Improved Nitric Oxide Bioavailability and Endothelial Function. J Am Heart Assoc. 2014; 3(6). PMID: 25468659.
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      39. Roche CJ, Talwar A, Palmer AF, Cabrales P, Gerfen G, Friedman JM. Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties. J Biol Chem. 2015 Jan 2; 290(1):99-117. PMID: 25371199; PMCID: PMC4281771.
      40. Tsai AG, Vázquez BY, Cabrales P, Kistler EB, Tartakovsky DM, Subramaniam S, Acharya SA, Intaglietta M. Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies. J Funct Biomater. 2014; 5(4):232-45. PMID: 25350267.
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      41. Tar M, Cabrales P, Navati M, Adler B, Nacharaju P, Friedman AJ, Friedman J, Davies KP. Topically applied NO-releasing nanoparticles can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy. J Sex Med. 2014 Dec; 11(12):2903-14. PMID: 25302850; NIHMSID: NIHMS625188.
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      42. Tsai AG, Cabrales P, Young MA, Winslow RM, Intaglietta M. Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia. Artif Cells Nanomed Biotechnol. 2015 Feb; 43(1):10-7. PMID: 25060721.
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      43. Liong C, Ortiz D, Ao-ieong E, Navati MS, Friedman JM, Cabrales P. Localized increase of tissue oxygen tension by magnetic targeted drug delivery. Nanotechnology. 2014 Jul 4; 25(26):265102. PMID: 24920392; NIHMSID: NIHMS610802.
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      44. Salazar Vázquez BY, Salazar Vázquez MA, Chávez-Negrete A, Escobedo G, Cabrales P, Subramaniam S, Intaglietta M, Pérez-Tamayo R. Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women. Vasc Health Risk Manag. 2014; 10:271-7. PMID: 24851053.
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      45. Chatpun S, Cabrales P. Nitric oxide synthase inhibition attenuates cardiac response to hemodilution with viscogenic plasma expander. Korean Circ J. 2014 Mar; 44(2):105-12. PMID: 24653740; PMCID: PMC3958604.
      46. Ortiz D, Briceño JC, Cabrales P. Microhemodynamic parameters quantification from intravital microscopy videos. Physiol Meas. 2014 Mar; 35(3):351-67. PMID: 24480871; NIHMSID: NIHMS601418.
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      47. Ortiz D, Barros M, Yan S, Cabrales P. Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood. Am J Emerg Med. 2014 Mar; 32(3):248-55. PMID: 24418449; NIHMSID: NIHMS547819.
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      48. Castro C, Ortiz D, Palmer AF, Cabrales P. Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin. Minerva Anestesiol. 2014 May; 80(5):537-46. PMID: 24280809.
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      49. Martini J, Cabrales P, Fries D, Intaglietta M, Tsai AG. Effects of fibrinogen concentrate after shock/resuscitation: a comparison between in vivo microvascular clot formation and thromboelastometry*. Crit Care Med. 2013 Nov; 41(11):e301-8. PMID: 23978812.
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      50. Cabrales P, Martins YC, Ong PK, Zanini GM, Frangos JA, Carvalho LJ. Cerebral tissue oxygenation impairment during experimental cerebral malaria. Virulence. 2013 Nov 15; 4(8):686-97. PMID: 24128424; PMCID: PMC3925700.
      51. Ortiz D, Cabrales P, Briceño JC. Transport of nitric oxide by perfluorocarbon emulsion. Biotechnol Prog. 2013 Nov-Dec; 29(6):1565-72. PMID: 23966236; NIHMSID: NIHMS613577.
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      52. Yalcin O, Ortiz D, Tsai AG, Johnson PC, Cabrales P. Microhemodynamic aberrations created by transfusion of stored blood. Transfusion. 2014 Apr; 54(4):1015-27. PMID: 23901933.
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      53. Cabrales P, Intaglietta M. Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids. ASAIO J. 2013 Jul-Aug; 59(4):337-54. PMID: 23820271.
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      54. Ong PK, Melchior B, Martins YC, Hofer A, Orjuela-Sánchez P, Cabrales P, Zanini GM, Frangos JA, Carvalho LJ. Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria. PLoS Pathog. 2013; 9(6):e1003444. PMID: 23818850; PMCID: PMC3688552.
      55. Vásquez DM, Ortiz D, Alvarez OA, Briceño JC, Cabrales P. Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood. Biotechnol Prog. 2013 May-Jun; 29(3):796-807. PMID: 23606592; NIHMSID: NIHMS476567.
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      56. Ju M, Ye SS, Low HT, Zhang J, Cabrales P, Leo HL, Kim S. Effect of deformability difference between two erythrocytes on their aggregation. Phys Biol. 2013 Jun; 10(3):036001. PMID: 23574688; NIHMSID: NIHMS468261.
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      57. Cabrales P, Friedman JM. HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species. Antioxid Redox Signal. 2013 Jun 10; 18(17):2284-97. PMID: 23249305.
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      58. Namgung B, Ju M, Cabrales P, Kim S. Two-phase model for prediction of cell-free layer width in blood flow. Microvasc Res. 2013 Jan; 85:68-76. PMID: 23116701; NIHMSID: NIHMS601430.
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      59. Cabrales P. Examining and mitigating acellular hemoglobin vasoactivity. Antioxid Redox Signal. 2013 Jun 10; 18(17):2329-41. PMID: 22938394; PMCID: PMC3638537.
      60. Elmer J, Palmer AF, Cabrales P. Oxygen delivery during extreme anemia with ultra-pure earthworm hemoglobin. Life Sci. 2012 Oct 29; 91(17-18):852-9. PMID: 22982347; NIHMSID: NIHMS407648.
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      61. Cabrales P, Rameez S, Palmer AF. Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin. Curr Drug Discov Technol. 2012 Sep; 9(3):224-34. PMID: 22564169.
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      62. Sriram K, Salazar Vázquez BY, Tsai AG, Cabrales P, Intaglietta M, Tartakovsky DM. Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit. Am J Physiol Heart Circ Physiol. 2012 Nov 1; 303(9):H1096-106. PMID: 22923620.
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      63. Chatpun S, Nacharaju P, Cabrales P. Improving cardiac function with new-generation plasma volume expanders. Am J Emerg Med. 2013 Jan; 31(1):54-63. PMID: 22867830; NIHMSID: NIHMS382428.
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      64. Landsverk SA, Tsai AG, Cabrales P, Intaglietta M. Impact of enzymatic degradation of the endothelial glycocalyx on vascular permeability in an awake hamster model. Crit Care Res Pract. 2012; 2012:842545. PMID: 22792450.
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      65. Nacharaju P, Tuckman-Vernon C, Maier KE, Chouake J, Friedman A, Cabrales P, Friedman JM. A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response. Nitric Oxide. 2012 Oct 15; 27(3):150-60. PMID: 22705913; NIHMSID: NIHMS612819.
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      66. Yalcin O, Cabrales P. Increased hemoglobin O2 affinity protects during acute hypoxia. Am J Physiol Heart Circ Physiol. 2012 Aug 1; 303(3):H271-81. PMID: 22636677; PMCID: PMC3423161.
      67. Hightower CM, Salazar Vázquez BY, Cabrales P, Tsai AG, Acharya SA, Intaglietta M. Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage. Transfusion. 2013 Jan; 53(1):49-59. PMID: 22554380.
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      68. Sriram K, Tsai AG, Cabrales P, Meng F, Acharya SA, Tartakovsky DM, Intaglietta M. PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning. Am J Physiol Heart Circ Physiol. 2012 Jun 15; 302(12):H2489-97. PMID: 22505638.
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      69. Zanini GM, Martins YC, Cabrales P, Frangos JA, Carvalho LJ. S-nitrosoglutathione prevents experimental cerebral malaria. J Neuroimmune Pharmacol. 2012 Jun; 7(2):477-87. PMID: 22391863; NIHMSID: NIHMS364409.
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      70. Elmer J, Zorc K, Rameez S, Zhou Y, Cabrales P, Palmer AF. Hypervolemic infusion of Lumbricus terrestris erythrocruorin purified by tangential-flow filtration. Transfusion. 2012 Aug; 52(8):1729-40. PMID: 22304397; NIHMSID: NIHMS342919.
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      71. Zhou Y, Cabrales P, Palmer AF. Simulation of NO and O2 transport facilitated by polymerized hemoglobin solutions in an arteriole that takes into account wall shear stress-induced NO production. Biophys Chem. 2012 Mar; 162:45-60. PMID: 22285312; NIHMSID: NIHMS348699.
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      72. Messmer C, Cabrales P, Intaglietta M. Effects of acute anemia and hyperoxia on oxygen distribution. Adv Exp Med Biol. 2012; 737:213-8. PMID: 22259104.
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      73. Messmer C, Yalcin O, Palmer AF, Cabrales P. Small-volume resuscitation from hemorrhagic shock with polymerized human serum albumin. Am J Emerg Med. 2012 Oct; 30(8):1336-46. PMID: 22100469; NIHMSID: NIHMS327823.
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      74. Chatpun S, Cabrales P. Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander. Life Sci. 2012 Jan 2; 90(1-2):39-46. PMID: 22056371; NIHMSID: NIHMS335077.
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      75. Palmer AF, Zhang N, Zhou Y, Harris DR, Cabrales P. Small-volume resuscitation from hemorrhagic shock using high-molecular-weight tense-state polymerized hemoglobins. J Trauma. 2011 Oct; 71(4):798-807. PMID: 21336190.
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      76. Villela NR, Tsai AG, Cabrales P, Intaglietta M. Improved resuscitation from hemorrhagic shock with Ringer's lactate with increased viscosity in the hamster window chamber model. J Trauma. 2011 Aug; 71(2):418-24. PMID: 21248647.
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      77. Chatpun S, Cabrales P. Effects on cardiac function of a novel low viscosity plasma expander based on polyethylene glycol conjugated albumin. Minerva Anestesiol. 2011 Jul; 77(7):704-14. PMID: 21709658.
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      78. Zanini GM, Cabrales P, Barkho W, Frangos JA, Carvalho LJ. Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice. J Neuroinflammation. 2011; 8:66. PMID: 21649904; PMCID: PMC3118350.
      79. Zhou Y, Jia Y, Buehler PW, Chen G, Cabrales P, Palmer AF. Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity. Biotechnol Prog. 2011 Jul; 27(4):1172-84. PMID: 21584950.
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      80. Cabrales P. Nanoengineering bactericidal nitric oxide therapies. Virulence. 2011 May-Jun; 2(3):185-7. PMID: 21670586.
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      81. Hightower CM, Salazar Vázquez BY, Woo Park S, Sriram K, Martini J, Yalcin O, Tsai AG, Cabrales P, Tartakovsky DM, Johnson PC, Intaglietta M. Integration of cardiovascular regulation by the blood/endothelium cell-free layer. Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug; 3(4):458-70. PMID: 21523919.
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      82. Chatpun S, Cabrales P. Cardiac systolic function recovery after hemorrhage determines survivability during shock. J Trauma. 2011 Apr; 70(4):787-93. PMID: 20805773; NIHMSID: NIHMS610808.
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      83. Cabrales P, Carlos Briceño J. Delaying blood transfusion in experimental acute anemia with a perfluorocarbon emulsion. Anesthesiology. 2011 Apr; 114(4):901-11. PMID: 21326091.
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      84. Cabrales P, Zanini GM, Meays D, Frangos JA, Carvalho LJ. Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology. J Infect Dis. 2011 May 15; 203(10):1454-63. PMID: 21415018; PMCID: PMC3080888.
      85. Nachuraju P, Friedman AJ, Friedman JM, Cabrales P. Exogenous nitric oxide prevents cardiovascular collapse during hemorrhagic shock. Resuscitation. 2011 May; 82(5):607-13. PMID: 21342744; NIHMSID: NIHMS274857.
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      86. Zhang N, Jia Y, Chen G, Cabrales P, Palmer AF. Biophysical properties and oxygenation potential of high-molecular-weight glutaraldehyde-polymerized human hemoglobins maintained in the tense and relaxed quaternary states. Tissue Eng Part A. 2011 Apr; 17(7-8):927-40. PMID: 20979534; PMCID: PMC3063705.
      87. Elmer J, Cabrales P, Wang Q, Zhang N, Palmer AF. Synthesis and biophysical properties of polymerized human serum albumin. Biotechnol Prog. 2011 Jan-Feb; 27(1):290-6. PMID: 21312376.
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      88. Yalcin O, Wang Q, Johnson PC, Palmer AF, Cabrales P. Plasma expander viscosity effects on red cell-free layer thickness after moderate hemodilution. Biorheology. 2011; 48(5):277-91. PMID: 22433569.
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      89. Salazar Vázquez BY, Cabrales P, Tsai AG, Intaglietta M. Nonlinear cardiovascular regulation consequent to changes in blood viscosity. Clin Hemorheol Microcirc. 2011; 49(1-4):29-36. PMID: 22214675.
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      90. Cabrales P, Carvalho LJ. Intravital microscopy of the mouse brain microcirculation using a closed cranial window. J Vis Exp. 2010; (45). PMID: 21113121; PMCID: PMC3074458.
      91. Cabrales P, Han G, Nacharaju P, Friedman AJ, Friedman JM. Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide. Am J Physiol Heart Circ Physiol. 2011 Jan; 300(1):H49-56. PMID: 21057038.
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      92. Cabrales P, Meng F, Acharya SA. Tissue oxidative metabolism after extreme hemodilution with PEG-conjugated hemoglobin. J Appl Physiol (1985). 2010 Dec; 109(6):1852-9. PMID: 20813980.
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      93. Vázquez BY, Martini J, Tsai AG, Johnson PC, Cabrales P, Intaglietta M. The variability of blood pressure due to small changes of hematocrit. Am J Physiol Heart Circ Physiol. 2010 Sep; 299(3):H863-7. PMID: 20601464.
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      94. Chatpun S, Cabrales P. Effects of plasma viscosity modulation on cardiac function during moderate hemodilution. Asian J Transfus Sci. 2010 Jul; 4(2):102-8. PMID: 20859509; PMCID: PMC2937285.
      95. Tsai AG, Hofmann A, Cabrales P, Intaglietta M. Perfusion vs. oxygen delivery in transfusion with "fresh" and "old" red blood cells: the experimental evidence. Transfus Apher Sci. 2010 Aug; 43(1):69-78. PMID: 20646963.
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      96. Cabrales P, Han G, Roche C, Nacharaju P, Friedman AJ, Friedman JM. Sustained release nitric oxide from long-lived circulating nanoparticles. Free Radic Biol Med. 2010 Aug 15; 49(4):530-8. PMID: 20460149.
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      97. Cabrales P. Low oxygen-affinity hemoglobin solution increases oxygenation of partially ischemic tissue during acute anemia. J Am Coll Surg. 2010 Mar; 210(3):271-9. PMID: 20193889.
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      98. Buehler PW, Zhou Y, Cabrales P, Jia Y, Sun G, Harris DR, Tsai AG, Intaglietta M, Palmer AF. Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins. Biomaterials. 2010 May; 31(13):3723-35. PMID: 20149433.
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      99. Cabrales P, Zhou Y, Harris DR, Palmer AF. Tissue oxygenation after exchange transfusion with ultrahigh-molecular-weight tense- and relaxed-state polymerized bovine hemoglobins. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H1062-71. PMID: 20061539.
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      100. Salazar Vázquez BY, Martini J, Chávez Negrete A, Tsai AG, Forconi S, Cabrales P, Johnson PC, Intaglietta M. Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence. Clin Hemorheol Microcirc. 2010; 44(2):75-85. PMID: 20203362.
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      101. Chatpun S, Cabrales P. Cardiac mechanoenergetic cost of elevated plasma viscosity after moderate hemodilution. Biorheology. 2010; 47(3-4):225-37. PMID: 21084746; NIHMSID: NIHMS610805.
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      102. Cabrales P. Low dose nitrite enhances perfusion after fluid resuscitation from hemorrhagic shock. Resuscitation. 2009 Dec; 80(12):1431-6. PMID: 19804938.
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      103. Cabrales P, Sun G, Zhou Y, Harris DR, Tsai AG, Intaglietta M, Palmer AF. Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. J Appl Physiol (1985). 2009 Nov; 107(5):1548-58. PMID: 19745190.
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      104. Cabrales P, Tsai AG, Intaglietta M. Exogenous nitric oxide induces protection during hemorrhagic shock. Resuscitation. 2009 Jun; 80(6):707-12. PMID: 19362408.
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      105. Cabrales P, Tsai AG, Intaglietta M. Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters. Shock. 2009 Mar; 31(3):300-7. PMID: 18636045.
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      106. Cabrales P, Tsai AG, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2212-8. PMID: 18835914.
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      107. Cabrales P, Tsai AG, Ananda K, Acharya SA, Intaglietta M. Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. Resuscitation. 2008 Oct; 79(1):139-46. PMID: 18621463.
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      108. Cabrales P, Tsai AG, Intaglietta M. Balance between vasoconstriction and enhanced oxygen delivery. Transfusion. 2008 Oct; 48(10):2087-95. PMID: 18631171.
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      109. Cabrales P, Tsai AG, Intaglietta M. Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock. Resuscitation. 2008 Jun; 77(3):379-86. PMID: 18308459.
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      110. Cabrales P, Tsai AG, Intaglietta M. Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes. Shock. 2007 Oct; 28(4):461-7. PMID: 17558350.
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      111. Cabrales P, Tsai AG, Intaglietta M. Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):354-61. PMID: 17884988.
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      112. Cabrales P, Intaglietta M, Tsai AG. Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation. 2007 Oct; 75(1):124-34. PMID: 17481796.
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      113. Cabrales P. Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia. Am J Physiol Heart Circ Physiol. 2007 Aug; 293(2):H1206-15. PMID: 17449555.
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      114. Cabrales P, Tsai AG, Intaglietta M. Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity? Shock. 2007 Apr; 27(4):380-9. PMID: 17414420.
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      115. Cabrales P, Vázquez BY, Tsai AG, Intaglietta M. Microvascular and capillary perfusion following glycocalyx degradation. J Appl Physiol (1985). 2007 Jun; 102(6):2251-9. PMID: 17347383.
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      116. Cabrales P, Tsai AG, Intaglietta M. Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin. Antioxid Redox Signal. 2007 Mar; 9(3):375-84. PMID: 17184174.
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      117. Cabrales P, Tsai AG, Intaglietta M. Hemorrhagic shock resuscitation with carbon monoxide saturated blood. Resuscitation. 2007 Feb; 72(2):306-18. PMID: 17092627.
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      118. Cabrales P, Tsai AG. Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2445-52. PMID: 16731641.
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      119. Cabrales P, Martini J, Intaglietta M, Tsai AG. Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H581-90. PMID: 16517943.
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      120. Cabrales P, Tsai AG, Johnson PC, Intaglietta M. Oxygen release from arterioles with normal flow and no-flow conditions. J Appl Physiol (1985). 2006 May; 100(5):1569-76. PMID: 16384838.
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      121. Cabrales P, Tsai AG, Intaglietta M. Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia. J Appl Physiol (1985). 2006 Apr; 100(4):1181-7. PMID: 16357070.
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      122. Cabrales P, Tsai AG, Winslow RM, Intaglietta M. Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2392-400. PMID: 16024576.
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      123. Cabrales P, Nacharaju P, Manjula BN, Tsai AG, Acharya SA, Intaglietta M. Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders. Shock. 2005 Jul; 24(1):66-73. PMID: 15988323.
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      124. Cabrales P, Intaglietta M, Tsai AG. Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding. Shock. 2005 Jun; 23(6):549-55. PMID: 15897809.
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      125. Cabrales P, Tsai AG, Winslow RM, Intaglietta M. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2146-53. PMID: 15637119.
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      126. Cabrales P, Tsai AG, Intaglietta M. Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1708-16. PMID: 15591096.
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      127. Cabrales P, Sakai H, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M. Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1885-92. PMID: 15563528.
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      128. Cabrales P, Tsai AG, Intaglietta M. Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock. Shock. 2004 Nov; 22(5):431-7. PMID: 15489635.
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      129. Cabrales P, Tsai AG, Intaglietta M. Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2825-33. PMID: 15297257.
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      130. Cabrales P, Tsai AG, Frangos JA, Briceño JC, Intaglietta M. Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H320-30. PMID: 15210452.
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      131. Cabrales P, Kanika ND, Manjula BN, Tsai AG, Acharya SA, Intaglietta M. Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber. Am J Physiol Heart Circ Physiol. 2004 Oct; 287(4):H1609-17. PMID: 15191899.
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      132. Cabrales P, Tsai AG, Intaglietta M. Microvascular pressure and functional capillary density in extreme hemodilution with low- and high-viscosity dextran and a low-viscosity Hb-based O2 carrier. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H363-73. PMID: 14975932.
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      133. Cabrales P, Acero C, Intaglietta M, Tsai AG. Measurement of the cardiac output in small animals by thermodilution. Microvasc Res. 2003 Sep; 66(2):77-82. PMID: 12935765.
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