Lalit Deshmukh

Title(s)Assistant Researcher, Chemistry and Biochemistry
SchoolAcademic Aff
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Miller Jenkins LM, Paine EL, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH. Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator. J Am Chem Soc. 2019 May 22; 141(20):8327-8338. PMID: 31042030.
      View in: PubMed
    2. Deshmukh L, Tugarinov V, Appella DH, Clore GM. Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy. Angew Chem Int Ed Engl. 2018 03 01; 57(10):2687-2691. PMID: 29345807.
      View in: PubMed
    3. Deshmukh L, Tugarinov V, Louis JM, Clore GM. Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9855-E9862. PMID: 29087351.
      View in: PubMed
    4. Deshmukh L, Louis JM, Ghirlando R, Clore GM. Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12456-12461. PMID: 27791180.
      View in: PubMed
    5. Deshmukh L, Schwieters CD, Grishaev A, Clore GM. Quantitative Characterization of Configurational Space Sampled by HIV-1 Nucleocapsid Using Solution NMR, X-ray Scattering and Protein Engineering. Chemphyschem. 2016 06 03; 17(11):1548-52. PMID: 26946052.
      View in: PubMed
    6. Louis JM, Deshmukh L, Sayer JM, Aniana A, Clore GM. Mutations Proximal to Sites of Autoproteolysis and the a-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease. Biochemistry. 2015 Sep 08; 54(35):5414-24. PMID: 26266692.
      View in: PubMed
    7. Deshmukh L, Ghirlando R, Clore GM. Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3374-9. PMID: 25713345; PMCID: PMC4371905.
    8. Gorbatyuk V, Nguyen K, Podolnikova NP, Deshmukh L, Lin X, Ugarova TP, Vinogradova O. Skelemin association with aIIbß3 integrin: a structural model. Biochemistry. 2014 Nov 04; 53(43):6766-75. PMID: 25224262; PMCID: PMC4222533.
    9. Deshmukh L, Ghirlando R, Clore GM. Investigation of the structure and dynamics of the capsid-spacer peptide 1-nucleocapsid fragment of the HIV-1 gag polyprotein by solution NMR spectroscopy. Angew Chem Int Ed Engl. 2014 Jan 20; 53(4):1025-8. PMID: 24338988.
      View in: PubMed
    10. Deshmukh L, Schwieters CD, Grishaev A, Ghirlando R, Baber JL, Clore GM. Structure and dynamics of full-length HIV-1 capsid protein in solution. J Am Chem Soc. 2013 Oct 30; 135(43):16133-47. PMID: 24066695.
      View in: PubMed
    11. West XZ, Meller N, Malinin NL, Deshmukh L, Meller J, Mahabeleshwar GH, Weber ME, Kerr BA, Vinogradova O, Byzova TV. Integrin ß3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switch. PLoS One. 2012; 7(2):e31071. PMID: 22363548; PMCID: PMC3281915.
    12. De Bona P, Deshmukh L, Gorbatyuk V, Vinogradova O, Kendall DA. Structural studies of a signal peptide in complex with signal peptidase I cytoplasmic domain: the stabilizing effect of membrane-mimetics on the acquired fold. Proteins. 2012 Mar; 80(3):807-17. PMID: 22113858; PMCID: PMC3277640.
    13. Deshmukh L, Meller N, Alder N, Byzova T, Vinogradova O. Tyrosine phosphorylation as a conformational switch: a case study of integrin ß3 cytoplasmic tail. J Biol Chem. 2011 Nov 25; 286(47):40943-53. PMID: 21956114; PMCID: PMC3220520.
    14. Deshmukh L, Gorbatyuk V, Vinogradova O. Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain. J Biol Chem. 2010 Nov 05; 285(45):34875-84. PMID: 20739287; PMCID: PMC2966102.
    15. Tyukhtenko S, Tiburu EK, Deshmukh L, Vinogradova O, Janero DR, Makriyannis A. NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: candidate electrostatic interactions and microdomain formation. Biochem Biophys Res Commun. 2009 Dec 18; 390(3):441-6. PMID: 19766594; PMCID: PMC3679914.
    16. Beierlein JM, Deshmukh L, Frey KM, Vinogradova O, Anderson AC. The solution structure of Bacillus anthracis dihydrofolate reductase yields insight into the analysis of structure-activity relationships for novel inhibitors. Biochemistry. 2009 May 19; 48(19):4100-8. PMID: 19323450; PMCID: PMC2810191.
    17. Tiburu EK, Tyukhtenko S, Deshmukh L, Vinogradova O, Janero DR, Makriyannis A. Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments. Biochem Biophys Res Commun. 2009 Jun 26; 384(2):243-8. PMID: 19397896; PMCID: PMC3679894.
    18. Deshmukh L, Wu L, Guttmann RP, Vinogradova O. NMR structural characterization of the penta-peptide calpain inhibitor. FEBS Lett. 2009 Jan 05; 583(1):135-40. PMID: 19059407.
      View in: PubMed
    19. Tyukhtenko S, Deshmukh L, Kumar V, Lary J, Cole J, Lemmon V, Vinogradova O. Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins. Biochemistry. 2008 Apr 01; 47(13):4160-8. PMID: 18321067; PMCID: PMC2426742.
    20. Deshmukh L, Tyukhtenko S, Liu J, Fox JE, Qin J, Vinogradova O. Structural insight into the interaction between platelet integrin alphaIIbbeta3 and cytoskeletal protein skelemin. J Biol Chem. 2007 Nov 02; 282(44):32349-56. PMID: 17804417.
      View in: PubMed