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    Michael Middleton

    TitleProject Scientist
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0888
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      University of California, IrvineMD1985Medicine
      University of CambridgePhD1979Physics
      California State UniversityBSc1972Physics
      University of California, San DiegoResidency1990Radiology
      Mercy Hospital Mercy Hospital (Transitional Internship)Internship1986
      Collapse Awards and Honors
      Metrohealth Medical Center, Case Western University2013Visiting Professor
      Memorial Sloan Kettering Hospital2010Visiting Professor
      Metrohealth Medical Center, Case Western University2008Visiting Professor
      University of California, Irvine1985Vincent P. Carroll Research Award
      University of Cambridge1975  - 1978James Clerk Maxwell Scholarship
      California State University1972B.Sc. with honors, cum laude
      University of Dundee (Scotland)1971  - 1972Study Abroad Program

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yokoo T, Serai SD, Pirasteh A, Bashir MR, Hamilton G, Hernando D, Hu HH, Hetterich H, Kühn JP, Kukuk GM, Loomba R, Middleton M, Obuchowski NA, Song JS, Tang A, Wu X, Reeder SB, Sirlin CB. Linearity, Bias, and Precision of Hepatic Proton Density Fat Fraction Measurements by Using MR Imaging: A Meta-Analysis. Radiology. 2017 Sep 11; 170550. PMID: 28892458.
        View in: PubMed
      2. Hong CW, Mamidipalli A, Hooker JC, Hamilton G, Wolfson T, Chen DH, Fazeli Dehkordy S, Middleton M, Reeder SB, Loomba R, Sirlin CB. MRI proton density fat fraction is robust across the biologically plausible range of triglyceride spectra in adults with nonalcoholic steatohepatitis. J Magn Reson Imaging. 2017 Aug 29. PMID: 28851124.
        View in: PubMed
      3. Middleton M, Heba ER, Hooker CA, Bashir MR, Fowler KJ, Sandrasegaran K, Brunt EM, Kleiner DE, Doo E, Van Natta ML, Lavine JE, Neuschwander-Tetri BA, Sanyal A, Loomba R, Sirlin CB. Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis. Gastroenterology. 2017 Sep; 153(3):753-761. PMID: 28624576.
        View in: PubMed
      4. Wang K, Manning P, Szeverenyi N, Wolfson T, Hamilton G, Middleton M, Vaida F, Yin M, Glaser K, Ehman RL, Sirlin CB. Repeatability and reproducibility of 2D and 3D hepatic MR elastography with rigid and flexible drivers at end-expiration and end-inspiration in healthy volunteers. Abdom Radiol (NY). 2017 Jun 13. PMID: 28612163.
        View in: PubMed
      5. Mamidipalli A, Hamilton G, Manning P, Hong CW, Park CC, Wolfson T, Hooker J, Heba E, Schlein A, Gamst A, Durelle J, Paiz M, Middleton M, Schwimmer JB, Sirlin CB. Cross-sectional correlation between hepatic R2* and proton density fat fraction (PDFF) in children with hepatic steatosis. J Magn Reson Imaging. 2017 May 25. PMID: 28543915.
        View in: PubMed
      6. Schwimmer JB, Behling C, Angeles JE, Paiz M, Durelle J, Africa J, Newton KP, Brunt EM, Lavine JE, Abrams SH, Masand P, Krishnamurthy R, Wong K, Ehman RL, Yin M, Glaser KJ, Dzyubak B, Wolfson T, Gamst AC, Hooker J, Haufe W, Schlein A, Hamilton G, Middleton M, Sirlin CB. Magnetic Resonance Elastography Measured Shear Stiffness as a Biomarker of Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease. Hepatology. 2017 May 11. PMID: 28493388.
        View in: PubMed
      7. Park CC, Hamilton G, Desai A, Zand KA, Wolfson T, Hooker JC, Costa E, Heba E, Clark L, Gamst A, Loomba R, Middleton M, Sirlin CB. Effect of intravenous gadoxetate disodium and flip angle on hepatic proton density fat fraction estimation with six-echo, gradient-recalled-echo, magnitude-based MR imaging at 3T. Abdom Radiol (NY). 2017 Apr; 42(4):1189-1198. PMID: 28028556.
        View in: PubMed
      8. Haufe WM, Wolfson T, Hooker CA, Hooker JC, Covarrubias Y, Schlein AN, Hamilton G, Middleton M, Angeles JE, Hernando D, Reeder SB, Schwimmer JB, Sirlin CB. Accuracy of PDFF estimation by magnitude-based and complex-based MRI in children with MR spectroscopy as a reference. J Magn Reson Imaging. 2017 Mar 21. PMID: 28323377.
        View in: PubMed
      9. Middleton M, Haufe W, Hooker J, Borga M, Dahlqvist Leinhard O, Romu T, Tunón P, Hamilton G, Wolfson T, Gamst A, Loomba R, Sirlin CB. Quantifying Abdominal Adipose Tissue and Thigh Muscle Volume and Hepatic Proton Density Fat Fraction: Repeatability and Accuracy of an MR Imaging-based, Semiautomated Analysis Method. Radiology. 2017 May; 283(2):438-449. PMID: 28278002.
        View in: PubMed
      10. Manning PM, Hamilton G, Wang K, Park C, Hooker JC, Wolfson T, Gamst A, Haufe WM, Schlein AN, Middleton M, Sirlin CB. Agreement between region-of-interest- and parametric map-based hepatic proton density fat fraction estimation in adults with chronic liver disease. Abdom Radiol (NY). 2017 Mar; 42(3):833-841. PMID: 27688063.
        View in: PubMed
      11. Manning P, Murphy P, Wang K, Hooker J, Wolfson T, Middleton M, Newton KP, Behling C, Awai HI, Durelle J, Paiz MN, Angeles JE, De La Pena D, McCutchan JA, Schwimmer JB, Sirlin CB. Liver histology and diffusion-weighted MRI in children with nonalcoholic fatty liver disease: A MAGNET study. J Magn Reson Imaging. 2017 Oct; 46(4):1149-1158. PMID: 28225568.
        View in: PubMed
      12. Yu NY, Wolfson T, Middleton M, Hamilton G, Gamst A, Angeles JE, Schwimmer JB, Sirlin CB. Bone marrow fat content is correlated with hepatic fat content in paediatric non-alcoholic fatty liver disease. Clin Radiol. 2017 May; 72(5):425.e9-425.e14. PMID: 28063601.
        View in: PubMed
      13. Hamilton G, Schlein AN, Middleton M, Hooker CA, Wolfson T, Gamst AC, Loomba R, Sirlin CB. In vivo triglyceride composition of abdominal adipose tissue measured by 1 H MRS at 3T. J Magn Reson Imaging. 2017 May; 45(5):1455-1463. PMID: 27571403.
        View in: PubMed
      14. McClellan TR, Motosugi U, Middleton M, Allen BC, Jaffe TA, Miller CM, Reeder SB, Sirlin CB, Bashir MR. Intravenous Gadoxetate Disodium Administration Reduces Breath-holding Capacity in the Hepatic Arterial Phase: A Multi-Center Randomized Placebo-controlled Trial. Radiology. 2017 Feb; 282(2):361-368. PMID: 27509544.
        View in: PubMed
      15. Tanabe M, Kanki A, Wolfson T, Costa EA, Mamidipalli A, Ferreira MP, Santillan C, Middleton M, Gamst AC, Kono Y, Kuo A, Sirlin CB. Imaging Outcomes of Liver Imaging Reporting and Data System Version 2014 Category 2, 3, and 4 Observations Detected at CT and MR Imaging. Radiology. 2016 Oct; 281(1):129-39. PMID: 27115054.
        View in: PubMed
      16. Tyagi A, Yeganeh O, Levin Y, Hooker JC, Hamilton GC, Wolfson T, Gamst A, Zand AK, Heba E, Loomba R, Schwimmer J, Middleton M, Sirlin CB. Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults. Abdom Imaging. 2015 Oct; 40(8):3070-7. PMID: 26350282; PMCID: PMC4819976.
      17. Achmad E, Yokoo T, Hamilton G, Heba ER, Hooker JC, Changchien C, Schroeder M, Wolfson T, Gamst A, Schwimmer JB, Lavine JE, Sirlin CB, Middleton M. Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease. Abdom Imaging. 2015 Oct; 40(8):3084-90. PMID: 26205992; PMCID: PMC4630122 [Available on 10/01/16].
      18. Yokoo T, Wolfson T, Iwaisako K, Peterson MR, Mani H, Goodman Z, Changchien C, Middleton M, Gamst AC, Mazhar SM, Kono Y, Ho SB, Sirlin CB. Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T. Biomed Res Int. 2015; 2015:387653. PMID: 26421287; PMCID: PMC4569760.
      19. Heba ER, Desai A, Zand KA, Hamilton G, Wolfson T, Schlein AN, Gamst A, Loomba R, Sirlin CB, Middleton M. Accuracy and the effect of possible subject-based confounders of magnitude-based MRI for estimating hepatic proton density fat fraction in adults, using MR spectroscopy as reference. J Magn Reson Imaging. 2016 Feb; 43(2):398-406. PMID: 26201284; PMCID: PMC4819980.
      20. Hamilton G, Middleton M, Hooker JC, Haufe WM, Forbang NI, Allison MA, Loomba R, Sirlin CB. In vivo breath-hold (1) H MRS simultaneous estimation of liver proton density fat fraction, and T1 and T2 of water and fat, with a multi-TR, multi-TE sequence. J Magn Reson Imaging. 2015 Dec; 42(6):1538-43. PMID: 26114603; PMCID: PMC4691228 [Available on 12/01/16].
      21. Costa EA, Cunha GM, Smorodinsky E, Cruite I, Tang A, Marks RM, Clark L, Wolfson T, Gamst A, Sicklick JK, Hemming A, Peterson MR, Middleton M, Sirlin CB. Diagnostic Accuracy of Preoperative Gadoxetic Acid-enhanced 3-T MR Imaging for Malignant Liver Lesions by Using Ex Vivo MR Imaging-matched Pathologic Findings as the Reference Standard. Radiology. 2015 Sep; 276(3):775-86. PMID: 25875972; PMCID: PMC4962530.
      22. Zand KA, Shah A, Heba E, Wolfson T, Hamilton G, Lam J, Chen J, Hooker JC, Gamst AC, Middleton M, Schwimmer JB, Sirlin CB. Accuracy of multiecho magnitude-based MRI (M-MRI) for estimation of hepatic proton density fat fraction (PDFF) in children. J Magn Reson Imaging. 2015 Nov; 42(5):1223-32. PMID: 25847512; PMCID: PMC4592685 [Available on 11/01/16].
      23. Schwimmer JB, Middleton M, Behling C, Newton KP, Awai HI, Paiz MN, Lam J, Hooker JC, Hamilton G, Fontanesi J, Sirlin CB. Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease. Hepatology. 2015 Jun; 61(6):1887-95. PMID: 25529941; PMCID: PMC4670559.
      24. Tang A, Chen J, Le TA, Changchien C, Hamilton G, Middleton M, Loomba R, Sirlin CB. Cross-sectional and longitudinal evaluation of liver volume and total liver fat burden in adults with nonalcoholic steatohepatitis. Abdom Imaging. 2015 Jan; 40(1):26-37. PMID: 25015398; PMCID: PMC4293373.
      25. Murphy P, Hooker J, Ang B, Wolfson T, Gamst A, Bydder M, Middleton M, Peterson M, Behling C, Loomba R, Sirlin C. Associations between histologic features of nonalcoholic fatty liver disease (NAFLD) and quantitative diffusion-weighted MRI measurements in adults. J Magn Reson Imaging. 2015 Jun; 41(6):1629-38. PMID: 25256692; PMCID: PMC4819971.
      26. Tang A, Desai A, Hamilton G, Wolfson T, Gamst A, Lam J, Clark L, Hooker J, Chavez T, Ang BD, Middleton M, Peterson M, Loomba R, Sirlin CB. Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease. Radiology. 2015 Feb; 274(2):416-25. PMID: 25247408; PMCID: PMC4314291.
      27. Valayannopoulos V, Malinova V, Honzík T, Balwani M, Breen C, Deegan PB, Enns GM, Jones SA, Kane JP, Stock EO, Tripuraneni R, Eckert S, Schneider E, Hamilton G, Middleton M, Sirlin C, Kessler B, Bourdon C, Boyadjiev SA, Sharma R, Twelves C, Whitley CB, Quinn AG. Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency. J Hepatol. 2014 Nov; 61(5):1135-42. PMID: 24993530; PMCID: PMC4203712.
      28. Bonekamp S, Tang A, Mashhood A, Wolfson T, Changchien C, Middleton M, Clark L, Gamst A, Loomba R, Sirlin CB. Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease. J Magn Reson Imaging. 2014 Jun; 39(6):1525-32. PMID: 24987758; PMCID: PMC4083476.
      29. Middleton M. MR evaluation of breast implants. Radiol Clin North Am. 2014 May; 52(3):591-608. PMID: 24792659.
        View in: PubMed
      30. Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, Bettencourt R, Changchien C, Brenner DA, Sirlin C, Loomba R. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013 Dec; 58(6):1930-40. PMID: 23696515; PMCID: PMC4819962.
      31. Negrete LM, Middleton M, Clark L, Wolfson T, Gamst AC, Lam J, Changchien C, Deyoung-Dominguez IM, Hamilton G, Loomba R, Schwimmer J, Sirlin CB. Inter-examination precision of magnitude-based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects. J Magn Reson Imaging. 2014 May; 39(5):1265-71. PMID: 24136736; PMCID: PMC3984359.
      32. Levin YS, Yokoo T, Wolfson T, Gamst AC, Collins J, Achmad EA, Hamilton G, Middleton M, Loomba R, Sirlin CB. Effect of echo-sampling strategy on the accuracy of out-of-phase and in-phase multiecho gradient-echo MRI hepatic fat fraction estimation. J Magn Reson Imaging. 2014 Mar; 39(3):567-75. PMID: 23720420; PMCID: PMC3760998.
      33. New M, Olzscha H, Liu G, Khan O, Stimson L, McGouran J, Kerr D, Coutts A, Kessler B, Middleton M, La Thangue NB. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell Death Differ. 2013 Oct; 20(10):1306-16. PMID: 23703321; PMCID: PMC3770323.
      34. Johnson BL, Schroeder ME, Wolfson T, Gamst AC, Hamilton G, Shiehmorteza M, Loomba R, Schwimmer JB, Reeder S, Middleton M, Sirlin CB. Effect of flip angle on the accuracy and repeatability of hepatic proton density fat fraction estimation by complex data-based, T1-independent, T2*-corrected, spectrum-modeled MRI. J Magn Reson Imaging. 2014 Feb; 39(2):440-7. PMID: 23596052; PMCID: PMC3732566.
      35. Tang A, Tan J, Sun M, Hamilton G, Bydder M, Wolfson T, Gamst AC, Middleton M, Brunt EM, Loomba R, Lavine JE, Schwimmer JB, Sirlin CB. Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology. 2013 May; 267(2):422-31. PMID: 23382291; PMCID: PMC3632805.
      36. Mashhood A, Railkar R, Yokoo T, Levin Y, Clark L, Fox-Bosetti S, Middleton M, Riek J, Kauh E, Dardzinski BJ, Williams D, Sirlin C, Shire NJ. Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging. J Magn Reson Imaging. 2013 Jun; 37(6):1359-70. PMID: 23172799.
        View in: PubMed
      37. Leslie T, Ritchie R, Illing R, Ter Haar G, Phillips R, Middleton M, Bch B, Wu F, Cranston D. High-intensity focused ultrasound treatment of liver tumours: post-treatment MRI correlates well with intra-operative estimates of treatment volume. Br J Radiol. 2012 Oct; 85(1018):1363-70. PMID: 22700259; PMCID: PMC3474034.
      38. Kang GH, Cruite I, Shiehmorteza M, Wolfson T, Gamst AC, Hamilton G, Bydder M, Middleton M, Sirlin CB. Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms. J Magn Reson Imaging. 2011 Oct; 34(4):928-34. PMID: 21769986; PMCID: PMC4803481.
      39. Yokoo T, Shiehmorteza M, Hamilton G, Wolfson T, Schroeder ME, Middleton M, Bydder M, Gamst AC, Kono Y, Kuo A, Patton HM, Horgan S, Lavine JE, Schwimmer JB, Sirlin CB. Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T. Radiology. 2011 Mar; 258(3):749-59. PMID: 21212366; PMCID: PMC3042639.
      40. Hamilton G, Yokoo T, Bydder M, Cruite I, Schroeder ME, Sirlin CB, Middleton M. In vivo characterization of the liver fat ¹H MR spectrum. NMR Biomed. 2011 Aug; 24(7):784-90. PMID: 21834002; PMCID: PMC3860876.
      41. Mitchell CL, O'Connor JP, Roberts C, Watson Y, Jackson A, Cheung S, Evans J, Spicer J, Harris A, Kelly C, Rudman S, Middleton M, Fielding A, Tessier J, Young H, Parker GJ, Jayson GC. A two-part phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics. Cancer Chemother Pharmacol. 2011 Sep; 68(3):631-41. PMID: 21120480.
        View in: PubMed
      42. Bydder M, Shiehmorteza M, Yokoo T, Sugay S, Middleton M, Girard O, Schroeder ME, Wolfson T, Gamst A, Sirlin C. Assessment of liver fat quantification in the presence of iron. Magn Reson Imaging. 2010 Jul; 28(6):767-76. PMID: 20409663; PMCID: PMC2924146.
      43. Schwimmer JB, Dunn W, Norman GJ, Pardee PE, Middleton M, Kerkar N, Sirlin CB. SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology. 2010 Apr; 138(4):1357-64, 1364.e1-2. PMID: 20064512; PMCID: PMC2846968.
      44. Ganesan K, Viamonte B, Peterson M, Kono Y, Santillan C, Middleton M, Sirlin C. Capsular retraction: an uncommon imaging finding in hepatic inflammatory pseudotumour. Br J Radiol. 2009 Dec; 82(984):e256-60. PMID: 19934068; PMCID: PMC3473395.
      45. Mazhar SM, Shiehmorteza M, Kohl CA, Middleton M, Sirlin CB. Nephrogenic systemic fibrosis in liver disease: a systematic review. J Magn Reson Imaging. 2009 Dec; 30(6):1313-22. PMID: 19937937; PMCID: PMC2844250.
      46. Hamilton G, Middleton M, Bydder M, Yokoo T, Schwimmer JB, Kono Y, Patton HM, Lavine JE, Sirlin CB. Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging. 2009 Jul; 30(1):145-52. PMID: 19557733; PMCID: PMC2982807.
      47. Yokoo T, Bydder M, Hamilton G, Middleton M, Gamst AC, Wolfson T, Hassanein T, Patton HM, Lavine JE, Schwimmer JB, Sirlin CB. Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology. 2009 Apr; 251(1):67-76. PMID: 19221054; PMCID: PMC2663579.
      48. Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork NJ, Shiehmorteza M, Yokoo T, Chavez A, Middleton M, Sirlin CB. Heritability of nonalcoholic fatty liver disease. Gastroenterology. 2009 May; 136(5):1585-92. PMID: 19208353; PMCID: PMC3397140.
      49. Cassidy FH, Yokoo T, Aganovic L, Hanna RF, Bydder M, Middleton M, Hamilton G, Chavez AD, Schwimmer JB, Sirlin CB. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics. 2009 Jan-Feb; 29(1):231-60. PMID: 19168847.
        View in: PubMed
      50. Yokoo T, Collins JM, Hanna RF, Bydder M, Middleton M, Sirlin CB. Effects of intravenous gadolinium administration and flip angle on the assessment of liver fat signal fraction with opposed-phase and in-phase imaging. J Magn Reson Imaging. 2008 Jul; 28(1):246-51. PMID: 18581393.
        View in: PubMed
      51. Bydder M, Yokoo T, Hamilton G, Middleton M, Chavez AD, Schwimmer JB, Lavine JE, Sirlin CB. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging. 2008 Apr; 26(3):347-59. PMID: 18093781; PMCID: PMC2386876.
      52. Shiehmorteza M, Hanna RF, Middleton M. Can gadopentetate dimeglumine be safely administered more rapidly than the FDA-approved injection rate for liver imaging? AJR Am J Roentgenol. 2007 Oct; 189(4):W231. PMID: 17885038.
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      53. Patton HM, Sirlin C, Behling C, Middleton M, Schwimmer JB, Lavine JE. Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future research. J Pediatr Gastroenterol Nutr. 2006 Oct; 43(4):413-27. PMID: 17033514.
        View in: PubMed
      54. Blair S, McElroy M, Middleton M, Comstock C, Wolfson T, Kamrava M, Wallace A, Mortimer J. The efficacy of breast MRI in predicting breast conservation therapy. J Surg Oncol. 2006 Sep 01; 94(3):220-5. PMID: 16900536.
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      55. Schwimmer JB, Middleton M, Deutsch R, Lavine JE. A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2005 Apr 01; 21(7):871-9. PMID: 15801922.
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      56. Parker PA, Middleton M, Kulik JA. Counterfactual thinking and quality of life among women with silicone breast implants. J Behav Med. 2002 Aug; 25(4):317-35. PMID: 12136495.
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      57. Berg WA, Nguyen TK, Middleton M, Soo MS, Pennello G, Brown SL. MR imaging of extracapsular silicone from breast implants: diagnostic pitfalls. AJR Am J Roentgenol. 2002 Feb; 178(2):465-72. PMID: 11804919.
        View in: PubMed
      58. Brown SL, Pennello G, Berg WA, Soo MS, Middleton M. Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women. J Rheumatol. 2001 May; 28(5):996-1003. PMID: 11361228.
        View in: PubMed
      59. Brown SL, Middleton M, Berg WA, Soo MS, Pennello G. Prevalence of rupture of silicone gel breast implants revealed on MR imaging in a population of women in Birmingham, Alabama. AJR Am J Roentgenol. 2000 Oct; 175(4):1057-64. PMID: 11000165.
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      60. Middleton M, Hardt NS, McNamara MP. The importance of documenting the appearance and status of breast implants at time of explantation. Mod Pathol. 2000 Sep; 13(9):1050. PMID: 11007049.
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      61. Middleton M. Magnetic resonance evaluation of breast implants and soft-tissue silicone. Top Magn Reson Imaging. 1998 Apr; 9(2):92-137. PMID: 9622095.
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      62. Georgy BA, Hesselink JR, Middleton M. Quantitative analysis of signal intensities and contrast after fat suppression in contrast-enhanced magnetic resonance imaging of the spine. Acad Radiol. 1996 Sep; 3(9):731-4. PMID: 8883513.
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      63. Georgy BA, Hesselink JR, Middleton M. Fat-suppression contrast-enhanced MRI in the failed back surgery syndrome: a prospective study. Neuroradiology. 1995 Jan; 37(1):51-7. PMID: 7708190.
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      64. Dobke MK, Middleton M. Clinical impact of breast implant magnetic resonance imaging. Ann Plast Surg. 1994 Sep; 33(3):241-6. PMID: 7985959.
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      65. Kreft BP, Tanimoto A, Baba Y, Zhao L, Chen J, Middleton M, Compton CC, Finn JP, Stark DD. Diagnosis of fatty liver with MR imaging. J Magn Reson Imaging. 1992 Jul-Aug; 2(4):463-71. PMID: 1633400.
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      66. Tien RD, Kucharczyk J, Bessette J, Middleton M. MR imaging of the pituitary gland in infants and children: changes in size, shape, and MR signal with growth and development. AJR Am J Roentgenol. 1992 May; 158(5):1151-4. PMID: 1566682.
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      67. Middleton M. MR diagnosis of acute osteomyelitis. AJR Am J Roentgenol. 1988 Sep; 151(3):612-3. PMID: 3261529.
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      68. Healy ME, Hesselink JR, Press GA, Middleton M. Increased detection of intracranial metastases with intravenous Gd-DTPA. Radiology. 1987 Dec; 165(3):619-24. PMID: 3317496.
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      69. Stark DD, Wittenberg J, Edelman RR, Middleton M, Saini S, Butch RJ, Brady TJ, Ferrucci JT. Detection of hepatic metastases: analysis of pulse sequence performance in MR imaging. Radiology. 1986 May; 159(2):365-70. PMID: 3008212.
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      70. Stark DD, Wittenberg J, Middleton M, Ferrucci JT. Liver metastases: detection by phase-contrast MR imaging. Radiology. 1986 Feb; 158(2):327-32. PMID: 3941859.
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