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    Karen Pierce

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0217
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Discovering Neural Biomarkers of Language and Social Development in ASD Toddlers
      NIH/NIDCD R01DC016385Sep 1, 2017 - Aug 31, 2022
      Role: Co-Principal Investigator
      Detection of ASD at the 1st birthday as standard of care: The Get SET Early Model
      NIH/NIMH R01MH104446Aug 25, 2014 - Jun 30, 2019
      Role: Principal Investigator
      Early Identification of ASD: Translating Eye Tracking into Practice
      NIH/NIMH R01MH080134Dec 17, 2007 - May 31, 2018
      Role: Principal Investigator
      Biomarkers of Autism at 12 months: From Brain Overgrowth to Genes
      NIH/NIMH P50MH081755Aug 6, 2007 - Jun 30, 2014
      Role: Co-Investigator
      NIH/NIMH K01MH001814Dec 10, 1999 - Jul 31, 2006
      Role: Principal Investigator
      NIH/NIMH F32MH011298Mar 1, 1996
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bacon EC, Courchesne E, Barnes CC, Cha D, Pence S, Schreibman L, Stahmer AC, Pierce K. Rethinking the idea of late autism spectrum disorder onset. Dev Psychopathol. 2017 Aug 14; 1-17. PMID: 28803559.
        View in: PubMed
      2. Geisheker MR, Heymann G, Wang T, Coe BP, Turner TN, Stessman HAF, Hoekzema K, Kvarnung M, Shaw M, Friend K, Liebelt J, Barnett C, Thompson EM, Haan E, Guo H, Anderlid BM, Nordgren A, Lindstrand A, Vandeweyer G, Alberti A, Avola E, Vinci M, Giusto S, Pramparo T, Pierce K, Nalabolu S, Michaelson JJ, Sedlacek Z, Santen GWE, Peeters H, Hakonarson H, Courchesne E, Romano C, Kooy RF, Bernier RA, Nordenskjöld M, Gecz J, Xia K, Zweifel LS, Eichler EE. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat Neurosci. 2017 Aug; 20(8):1043-1051. PMID: 28628100.
        View in: PubMed
      3. Stessman HA, Xiong B, Coe BP, Wang T, Hoekzema K, Fenckova M, Kvarnung M, Gerdts J, Trinh S, Cosemans N, Vives L, Lin J, Turner TN, Santen G, Ruivenkamp C, Kriek M, van Haeringen A, Aten E, Friend K, Liebelt J, Barnett C, Haan E, Shaw M, Gecz J, Anderlid BM, Nordgren A, Lindstrand A, Schwartz C, Kooy RF, Vandeweyer G, Helsmoortel C, Romano C, Alberti A, Vinci M, Avola E, Giusto S, Courchesne E, Pramparo T, Pierce K, Nalabolu S, Amaral DG, Scheffer IE, Delatycki MB, Lockhart PJ, Hormozdiari F, Harich B, Castells-Nobau A, Xia K, Peeters H, Nordenskjöld M, Schenck A, Bernier RA, Eichler EE. Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases. Nat Genet. 2017 Apr; 49(4):515-526. PMID: 28191889.
        View in: PubMed
      4. Fingher N, Dinstein I, Ben-Shachar M, Haar S, Dale AM, Eyler L, Pierce K, Courchesne E. Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers. Cortex. 2017 Jan 23. PMID: 28202133.
        View in: PubMed
      5. Pierce K, Courchesne E, Bacon E. To Screen or Not to Screen Universally for Autism is not the Question: Why the Task Force Got It Wrong. J Pediatr. 2016 Sep; 176:182-94. PMID: 27421956.
        View in: PubMed
      6. Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria KC, Beltrao-Braga PC, Trujillo CA, Mendes AP, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand KJ, Pierce K, Eichenfield L, Pramparo T, Eyler LT, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2016 Jul 05. PMID: 27378147.
        View in: PubMed
      7. Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 07; 98(4):667-79. PMID: 27018473; PMCID: PMC4833290 [Available on 10/07/16].
      8. Pramparo T, Lombardo MV, Campbell K, Barnes CC, Marinero S, Solso S, Young J, Mayo M, Dale A, Ahrens-Barbeau C, Murray SS, Lopez L, Lewis N, Pierce K, Courchesne E. Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers. Mol Syst Biol. 2015 Dec 14; 11(12):841. PMID: 26668231; PMCID: PMC4704485.
      9. Zwaigenbaum L, Bauman ML, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins DL, Wetherby A, Choueiri R, Kasari C, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S. Early Screening of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S41-59. PMID: 26430169.
        View in: PubMed
      10. Zwaigenbaum L, Bauman ML, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Choueiri R, Fein D, Kasari C, Pierce K, Buie T, Carter A, Davis PA, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Roley SS, Wagner S, Wetherby A. Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S10-40. PMID: 26430168.
        View in: PubMed
      11. Zwaigenbaum L, Bauman ML, Choueiri R, Fein D, Kasari C, Pierce K, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Buie T, Carter A, Davis PA, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Smith Roley S, Wagner S, Wetherby A. Early Identification and Interventions for Autism Spectrum Disorder: Executive Summary. Pediatrics. 2015 Oct; 136 Suppl 1:S1-9. PMID: 26430167.
        View in: PubMed
      12. Zwaigenbaum L, Bauman ML, Choueiri R, Kasari C, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins D, Wetherby A, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR. Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S60-81. PMID: 26430170.
        View in: PubMed
      13. Solso S, Xu R, Proudfoot J, Hagler DJ, Campbell K, Venkatraman V, Carter Barnes C, Ahrens-Barbeau C, Pierce K, Dale A, Eyler L, Courchesne E. Diffusion Tensor Imaging Provides Evidence of Possible Axonal Overconnectivity in Frontal Lobes in Autism Spectrum Disorder Toddlers. Biol Psychiatry. 2016 Apr 15; 79(8):676-84. PMID: 26300272; PMCID: PMC4699869 [Available on 04/15/17].
      14. Pierce K, Marinero S, Hazin R, McKenna B, Barnes CC, Malige A. Eye Tracking Reveals Abnormal Visual Preference for Geometric Images as an Early Biomarker of an Autism Spectrum Disorder Subtype Associated With Increased Symptom Severity. Biol Psychiatry. 2016 Apr 15; 79(8):657-66. PMID: 25981170; PMCID: PMC4600640 [Available on 04/15/17].
      15. Lombardo MV, Pierce K, Eyler LT, Carter Barnes C, Ahrens-Barbeau C, Solso S, Campbell K, Courchesne E. Different functional neural substrates for good and poor language outcome in autism. Neuron. 2015 Apr 22; 86(2):567-77. PMID: 25864635; PMCID: PMC4610713.
      16. Pramparo T, Pierce K, Lombardo MV, Carter Barnes C, Marinero S, Ahrens-Barbeau C, Murray SS, Lopez L, Xu R, Courchesne E. Prediction of autism by translation and immune/inflammation coexpressed genes in toddlers from pediatric community practices. JAMA Psychiatry. 2015 Apr; 72(4):386-94. PMID: 25739104.
        View in: PubMed
      17. Bacon EC, Dufek S, Schreibman L, Stahmer AC, Pierce K, Courchesne E. Measuring outcome in an early intervention program for toddlers with autism spectrum disorder: use of a curriculum-based assessment. Autism Res Treat. 2014; 2014:964704. PMID: 24711926; PMCID: PMC3966353.
      18. Glatt SJ, Tsuang MT, Winn M, Chandler SD, Collins M, Lopez L, Weinfeld M, Carter C, Schork N, Pierce K, Courchesne E. Blood-based gene expression signatures of infants and toddlers with autism. J Am Acad Child Adolesc Psychiatry. 2012 Sep; 51(9):934-44.e2. PMID: 22917206; PMCID: PMC3756503.
      19. Eyler LT, Pierce K, Courchesne E. A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism. Brain. 2012 Mar; 135(Pt 3):949-60. PMID: 22350062; PMCID: PMC3286331.
      20. Courchesne E, Mouton PR, Calhoun ME, Semendeferi K, Ahrens-Barbeau C, Hallet MJ, Barnes CC, Pierce K. Neuron number and size in prefrontal cortex of children with autism. JAMA. 2011 Nov 09; 306(18):2001-10. PMID: 22068992.
        View in: PubMed
      21. Dinstein I, Pierce K, Eyler L, Solso S, Malach R, Behrmann M, Courchesne E. Disrupted neural synchronization in toddlers with autism. Neuron. 2011 Jun 23; 70(6):1218-25. PMID: 21689606; PMCID: PMC3119852.
      22. Pierce K, Carter C, Weinfeld M, Desmond J, Hazin R, Bjork R, Gallagher N. Detecting, studying, and treating autism early: the one-year well-baby check-up approach. J Pediatr. 2011 Sep; 159(3):458-465.e1-6. PMID: 21524759; PMCID: PMC3157595.
      23. Pierce K. Early functional brain development in autism and the promise of sleep fMRI. Brain Res. 2011 Mar 22; 1380:162-74. PMID: 20869953; PMCID: PMC3050065.
      24. Pierce K, Conant D, Hazin R, Stoner R, Desmond J. Preference for geometric patterns early in life as a risk factor for autism. Arch Gen Psychiatry. 2011 Jan; 68(1):101-9. PMID: 20819977; PMCID: PMC4894313.
      25. Schumann CM, Bloss CS, Barnes CC, Wideman GM, Carper RA, Akshoomoff N, Pierce K, Hagler D, Schork N, Lord C, Courchesne E. Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism. J Neurosci. 2010 Mar 24; 30(12):4419-27. PMID: 20335478; PMCID: PMC2859218.
      26. Pierce K, Glatt SJ, Liptak GS, McIntyre LL. The power and promise of identifying autism early: insights from the search for clinical and biological markers. Ann Clin Psychiatry. 2009 Jul-Sep; 21(3):132-47. PMID: 19758535; PMCID: PMC4872627.
      27. Luyster R, Gotham K, Guthrie W, Coffing M, Petrak R, Pierce K, Bishop S, Esler A, Hus V, Oti R, Richler J, Risi S, Lord C. The Autism Diagnostic Observation Schedule-toddler module: a new module of a standardized diagnostic measure for autism spectrum disorders. J Autism Dev Disord. 2009 Sep; 39(9):1305-20. PMID: 19415479; PMCID: PMC2893552.
      28. Pierce K, Redcay E. Fusiform function in children with an autism spectrum disorder is a matter of "who". Biol Psychiatry. 2008 Oct 01; 64(7):552-60. PMID: 18621359; PMCID: PMC2673799.
      29. Courchesne E, Pierce K, Schumann CM, Redcay E, Buckwalter JA, Kennedy DP, Morgan J. Mapping early brain development in autism. Neuron. 2007 Oct 25; 56(2):399-413. PMID: 17964254.
        View in: PubMed
      30. Courchesne E, Pierce K. Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. Curr Opin Neurobiol. 2005 Apr; 15(2):225-30. PMID: 15831407.
        View in: PubMed
      31. Courchesne E, Pierce K. Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal neuron and interneuron development and connectivity. Int J Dev Neurosci. 2005 Apr-May; 23(2-3):153-70. PMID: 15749242.
        View in: PubMed
      32. Teder-Sälejärvi WA, Pierce K, Courchesne E, Hillyard SA. Auditory spatial localization and attention deficits in autistic adults. Brain Res Cogn Brain Res. 2005 May; 23(2-3):221-34. PMID: 15820630.
        View in: PubMed
      33. Pierce K, Haist F, Sedaghat F, Courchesne E. The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain. 2004 Dec; 127(Pt 12):2703-16. PMID: 15319275.
        View in: PubMed
      34. Müller RA, Kleinhans N, Kemmotsu N, Pierce K, Courchesne E. Abnormal variability and distribution of functional maps in autism: an FMRI study of visuomotor learning. Am J Psychiatry. 2003 Oct; 160(10):1847-62. PMID: 14514501.
        View in: PubMed
      35. Müller RA, Kleinhans N, Pierce K, Kemmotsu N, Courchesne E. Functional MRI of motor sequence acquisition: effects of learning stage and performance. Brain Res Cogn Brain Res. 2002 Aug; 14(2):277-93. PMID: 12067701.
        View in: PubMed
      36. Akshoomoff N, Pierce K, Courchesne E. The neurobiological basis of autism from a developmental perspective. Dev Psychopathol. 2002; 14(3):613-34. PMID: 12349876.
        View in: PubMed
      37. Sherer M, Pierce K, Paredes S, Kisacky KL, Ingersoll B, Schreibman L. Enhancing conversation skills in children with autism via video technology. Which is better, "self" or "other" as a model? Behav Modif. 2001 Jan; 25(1):140-58. PMID: 11151482.
        View in: PubMed
      38. Cao W, Luttrell LM, Medvedev AV, Pierce K, Daniel KW, Dixon TM, Lefkowitz RJ, Collins S. Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. J Biol Chem. 2000 Dec 08; 275(49):38131-4. PMID: 11013230.
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      39. Pierce K, Schreibman L. Teaching daily living skills to children with autism in unsupervised settings through pictorial self-management. J Appl Behav Anal. 1994; 27(3):471-81. PMID: 7928790; PMCID: PMC1297828.