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    Donald Helinski

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0322
    CA La Jolla 92093
    Phone858-534-3638
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      Collapse Research 
      Collapse Research Activities and Funding
      Structure and Genetic Control of Colicines
      NIH/NIAID R01AI007194Feb 1, 1978 - Apr 30, 2007
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Verheust C, Helinski D. The incC korB region of RK2 repositions a mini-RK2 replicon in Escherichia coli. Plasmid. 2007 Sep; 58(2):195-204. PMID: 17521722.
        View in: PubMed
      2. Yao S, Helinski D, Toukdarian A. Localization of the naturally occurring plasmid ColE1 at the cell pole. J Bacteriol. 2007 Mar; 189(5):1946-53. PMID: 17158664; PMCID: PMC1855736.
      3. Yao S, Toukdarian A, Helinski D. Inhibition of protein and RNA synthesis in Escherichia coli results in declustering of plasmid RK2. Plasmid. 2006 Sep; 56(2):124-32. PMID: 16774785.
        View in: PubMed
      4. Jiang Y, Yao S, Helinski D, Toukdarian A. Functional analysis of two putative chromosomal replication origins from Pseudomonas aeruginosa. Plasmid. 2006 May; 55(3):194-200. PMID: 16376988.
        View in: PubMed
      5. Johnson EP, Yao S, Helinski D. Gyrase inhibitors and thymine starvation disrupt the normal pattern of plasmid RK2 localization in Escherichia coli. J Bacteriol. 2005 May; 187(10):3538-47. PMID: 15866942; PMCID: PMC1112003.
      6. Zhong Z, Helinski D, Toukdarian A. Plasmid host-range: restrictions to F replication in Pseudomonas. Plasmid. 2005 Jul; 54(1):48-56. PMID: 15907538.
        View in: PubMed
      7. Harrison SA, Fincke C, Helinski D, Torgerson S, Hayashi P. A pilot study of orlistat treatment in obese, non-alcoholic steatohepatitis patients. Aliment Pharmacol Ther. 2004 Sep 15; 20(6):623-8. PMID: 15352910.
        View in: PubMed
      8. Zhong Z, Helinski D, Toukdarian A. A specific region in the N terminus of a replication initiation protein of plasmid RK2 is required for recruitment of Pseudomonas aeruginosa DnaB helicase to the plasmid origin. J Biol Chem. 2003 Nov 14; 278(46):45305-10. PMID: 12952979.
        View in: PubMed
      9. Jiang Y, Pacek M, Helinski D, Konieczny I, Toukdarian A. A multifunctional plasmid-encoded replication initiation protein both recruits and positions an active helicase at the replication origin. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8692-7. PMID: 12835421; PMCID: PMC166374.
      10. Zhong Z, Caspi R, Helinski D, Knauf V, Sykes S, O'Byrne C, Shea TP, Wilkinson JE, DeLoughery C, Toukdarian A. Nucleotide sequence based characterizations of two cryptic plasmids from the marine bacterium Ruegeria isolate PR1b. Plasmid. 2003 May; 49(3):233-52. PMID: 12749836.
        View in: PubMed
      11. Jiang Y, Pogliano J, Helinski D, Konieczny I. ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase. Mol Microbiol. 2002 May; 44(4):971-9. PMID: 12010492.
        View in: PubMed
      12. Zhong Z, Caspi R, Mincer T, Helinski D, Knauf V, Boardman K, Wilkinson JE, Shea T, DeLoughery C, Toukdarian A. A 50-kb plasmid rich in mobile gene sequences isolated from a marine micrococcus. Plasmid. 2002 Jan; 47(1):1-9. PMID: 11798280.
        View in: PubMed
      13. Zhong Z, Toukdarian A, Helinski D, Knauf V, Sykes S, Wilkinson JE, O'Bryne C, Shea T, DeLoughery C, Caspi R. Sequence analysis of a 101-kilobase plasmid required for agar degradation by a Microscilla isolate. Appl Environ Microbiol. 2001 Dec; 67(12):5771-9. PMID: 11722934; PMCID: PMC93371.
      14. Caspi R, Pacek M, Consiglieri G, Helinski D, Toukdarian A, Konieczny I. A broad host range replicon with different requirements for replication initiation in three bacterial species. EMBO J. 2001 Jun 15; 20(12):3262-71. PMID: 11406602; PMCID: PMC150194.
      15. Pogliano J, Ho TQ, Zhong Z, Helinski D. Multicopy plasmids are clustered and localized in Escherichia coli. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4486-91. PMID: 11274369; PMCID: PMC31861.
      16. Baranska S, Gabig M, Wegrzyn A, Konopa G, Herman-Antosiewicz A, Hernandez P, Schvartzman JB, Helinski D, Wegrzyn G. Regulation of the switch from early to late bacteriophage lambda DNA replication. Microbiology. 2001 Mar; 147(Pt 3):535-47. PMID: 11238961.
        View in: PubMed
      17. Caspi R, Helinski D, Pacek M, Konieczny I. Interactions of DnaA proteins from distantly related bacteria with the replication origin of the broad host range plasmid RK2. J Biol Chem. 2000 Jun 16; 275(24):18454-61. PMID: 10749858.
        View in: PubMed
      18. Johnson EP, Mincer T, Schwab H, Burgin AB, Helinski D. Plasmid RK2 ParB protein: purification and nuclease properties. J Bacteriol. 1999 Oct; 181(19):6010-8. PMID: 10498713; PMCID: PMC103628.
      19. Doran KS, Helinski D, Konieczny I. Host-dependent requirement for specific DnaA boxes for plasmid RK2 replication. Mol Microbiol. 1999 Aug; 33(3):490-8. PMID: 10417640.
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      20. Doran KS, Helinski D, Konieczny I. A critical DnaA box directs the cooperative binding of the Escherichia coli DnaA protein to the plasmid RK2 replication origin. J Biol Chem. 1999 Jun 18; 274(25):17918-23. PMID: 10364238.
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      21. Toukdarian AE, Helinski D. TrfA dimers play a role in copy-number control of RK2 replication. Gene. 1998 Nov 26; 223(1-2):205-11. PMID: 9858734.
        View in: PubMed
      22. Easter CL, Schwab H, Helinski D. Role of the parCBA operon of the broad-host-range plasmid RK2 in stable plasmid maintenance. J Bacteriol. 1998 Nov; 180(22):6023-30. PMID: 9811663; PMCID: PMC107679.
      23. Szalewska-Palasz A, Lemieszek E, Pankiewicz A, Wegrzyn A, Helinski D, Wegrzyn G. Escherichia coli dnaA gene function and bacteriophage lambda replication. FEMS Microbiol Lett. 1998 Oct 01; 167(1):27-32. PMID: 9785448.
        View in: PubMed
      24. Sobecky PA, Mincer TJ, Chang MC, Toukdarian A, Helinski D. Isolation of broad-host-range replicons from marine sediment bacteria. Appl Environ Microbiol. 1998 Aug; 64(8):2822-30. PMID: 9687436; PMCID: PMC106778.
      25. Doran KS, Konieczny I, Helinski D. Replication origin of the broad host range plasmid RK2. Positioning of various motifs is critical for initiation of replication. J Biol Chem. 1998 Apr 03; 273(14):8447-53. PMID: 9525957.
        View in: PubMed
      26. Konieczny I, Helinski D. Helicase delivery and activation by DnaA and TrfA proteins during the initiation of replication of the broad host range plasmid RK2. J Biol Chem. 1997 Dec 26; 272(52):33312-8. PMID: 9407123.
        View in: PubMed
      27. Konieczny I, Helinski D. The replication initiation protein of the broad-host-range plasmid RK2 is activated by the ClpX chaperone. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14378-82. PMID: 9405620; PMCID: PMC24985.
      28. Easter CL, Sobecky PA, Helinski D. Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2. J Bacteriol. 1997 Oct; 179(20):6472-9. PMID: 9335298; PMCID: PMC179565.
      29. Konieczny I, Doran KS, Helinski D, Blasina A. Role of TrfA and DnaA proteins in origin opening during initiation of DNA replication of the broad host range plasmid RK2. J Biol Chem. 1997 Aug 08; 272(32):20173-8. PMID: 9242693.
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      30. Sobecky PA, Mincer TJ, Chang MC, Helinski D. Plasmids isolated from marine sediment microbial communities contain replication and incompatibility regions unrelated to those of known plasmid groups. Appl Environ Microbiol. 1997 Mar; 63(3):888-95. PMID: 9055407; PMCID: PMC168381.
      31. Blasina A, Kittell BL, Toukdarian AE, Helinski D. Copy-up mutants of the plasmid RK2 replication initiation protein are defective in coupling RK2 replication origins. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3559-64. PMID: 8622975; PMCID: PMC39649.
      32. Sobecky PA, Easter CL, Bear PD, Helinski D. Characterization of the stable maintenance properties of the par region of broad-host-range plasmid RK2. J Bacteriol. 1996 Apr; 178(7):2086-93. PMID: 8606188; PMCID: PMC177909.
      33. Toukdarian AE, Helinski D, Perri S. The plasmid RK2 initiation protein binds to the origin of replication as a monomer. J Biol Chem. 1996 Mar 22; 271(12):7072-8. PMID: 8636140.
        View in: PubMed
      34. Johnson EP, Strom AR, Helinski D. Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein. J Bacteriol. 1996 Mar; 178(5):1420-9. PMID: 8631720; PMCID: PMC177817.
      35. Sia EA, Roberts RC, Easter C, Helinski D, Figurski DH. Different relative importances of the par operons and the effect of conjugal transfer on the maintenance of intact promiscuous plasmid RK2. J Bacteriol. 1995 May; 177(10):2789-97. PMID: 7751288; PMCID: PMC176950.
      36. Wegrzyn G, Wegrzyn A, Konieczny I, Bielawski K, Konopa G, Obuchowski M, Helinski D, Taylor K. Involvement of the host initiator function dnaA in the replication of coliphage lambda. Genetics. 1995 Apr; 139(4):1469-81. PMID: 7789753; PMCID: PMC1206477.
      37. Monson EK, Ditta GS, Helinski D. The oxygen sensor protein, FixL, of Rhizobium meliloti. Role of histidine residues in heme binding, phosphorylation, and signal transduction. J Biol Chem. 1995 Mar 10; 270(10):5243-50. PMID: 7890634.
        View in: PubMed
      38. Pansegrau W, Lanka E, Barth PT, Figurski DH, Guiney DG, Haas D, Helinski D, Schwab H, Stanisich VA, Thomas CM. Complete nucleotide sequence of Birmingham IncP alpha plasmids. Compilation and comparative analysis. J Mol Biol. 1994 Jun 24; 239(5):623-63. PMID: 8014987.
        View in: PubMed
      39. Agron PG, Monson EK, Ditta GS, Helinski D. Oxygen regulation of expression of nitrogen fixation genes in Rhizobium meliloti. Res Microbiol. 1994 Jun-Aug; 145(5-6):454-9. PMID: 7855432.
        View in: PubMed
      40. Roberts RC, Ström AR, Helinski D. The parDE operon of the broad-host-range plasmid RK2 specifies growth inhibition associated with plasmid loss. J Mol Biol. 1994 Mar 18; 237(1):35-51. PMID: 8133518.
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      41. Cereghino JL, Helinski D, Toukdarian AE. Isolation and characterization of DNA-binding mutants of a plasmid replication initiation protein utilizing an in vivo binding assay. Plasmid. 1994 Jan; 31(1):89-99. PMID: 8171128.
        View in: PubMed
      42. Roberts RC, Spangler C, Helinski D. Characteristics and significance of DNA binding activity of plasmid stabilization protein ParD from the broad host-range plasmid RK2. J Biol Chem. 1993 Dec 25; 268(36):27109-17. PMID: 8262949.
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      43. Weinstein M, Lois AF, Ditta GS, Helinski D. Mutants of the two-component regulatory protein FixJ of Rhizobium meliloti that have increased activity at the nifA promoter. Gene. 1993 Dec 08; 134(2):145-52. PMID: 8262372.
        View in: PubMed
      44. Cereghino JL, Helinski D. Essentiality of the three carboxyl-terminal amino acids of the plasmid RK2 replication initiation protein TrfA for DNA binding and replication activity in gram-negative bacteria. J Biol Chem. 1993 Nov 25; 268(33):24926-32. PMID: 8227054.
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      45. Fang FC, Durland RH, Helinski D. Mutations in the gene encoding the replication-initiation protein of plasmid RK2 produce elevated copy numbers of RK2 derivatives in Escherichia coli and distantly related bacteria. Gene. 1993 Oct 29; 133(1):1-8. PMID: 8224880.
        View in: PubMed
      46. Agron PG, Ditta GS, Helinski D. Oxygen regulation of nifA transcription in vitro. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3506-10. PMID: 8475099; PMCID: PMC46329.
      47. Lois AF, Weinstein M, Ditta GS, Helinski D. Autophosphorylation and phosphatase activities of the oxygen-sensing protein FixL of Rhizobium meliloti are coordinately regulated by oxygen. J Biol Chem. 1993 Feb 25; 268(6):4370-5. PMID: 8382700.
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      48. Perri S, Helinski D. DNA sequence requirements for interaction of the RK2 replication initiation protein with plasmid origin repeats. J Biol Chem. 1993 Feb 15; 268(5):3662-9. PMID: 8429042.
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      49. Lois AF, Ditta GS, Helinski D. The oxygen sensor FixL of Rhizobium meliloti is a membrane protein containing four possible transmembrane segments. J Bacteriol. 1993 Feb; 175(4):1103-9. PMID: 8432704; PMCID: PMC193026.
      50. Roberts RC, Helinski D. Definition of a minimal plasmid stabilization system from the broad-host-range plasmid RK2. J Bacteriol. 1992 Dec; 174(24):8119-32. PMID: 1459960; PMCID: PMC207551.
      51. Weinstein M, Roberts RC, Helinski D. A region of the broad-host-range plasmid RK2 causes stable in planta inheritance of plasmids in Rhizobium meliloti cells isolated from alfalfa root nodules. J Bacteriol. 1992 Nov; 174(22):7486-9. PMID: 1429472; PMCID: PMC207450.
      52. Weinstein M, Lois AF, Monson EK, Ditta GS, Helinski D. Isolation of phosphorylation-deficient mutants of the Rhizobium meliloti two-component regulatory protein, FixJ. Mol Microbiol. 1992 Aug; 6(15):2041-9. PMID: 1406247.
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      53. Davis TL, Helinski D, Roberts RC. Transcription and autoregulation of the stabilizing functions of broad-host-range plasmid RK2 in Escherichia coli, Agrobacterium tumefaciens and Pseudomonas aeruginosa. Mol Microbiol. 1992 Jul; 6(14):1981-94. PMID: 1508045.
        View in: PubMed
      54. Agron PG, Ditta GS, Helinski D. Mutational analysis of the Rhizobium meliloti nifA promoter. J Bacteriol. 1992 Jun; 174(12):4120-9. PMID: 1597427; PMCID: PMC206124.
      55. Lin J, Helinski D. Analysis of mutations in trfA, the replication initiation gene of the broad-host-range plasmid RK2. J Bacteriol. 1992 Jun; 174(12):4110-9. PMID: 1597426; PMCID: PMC206123.
      56. Monson EK, Weinstein M, Ditta GS, Helinski D. The FixL protein of Rhizobium meliloti can be separated into a heme-binding oxygen-sensing domain and a functional C-terminal kinase domain. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4280-4. PMID: 1584762; PMCID: PMC49065.
      57. Greener A, Lehman SM, Helinski D. Promoters of the broad host range plasmid RK2: analysis of transcription (initiation) in five species of gram-negative bacteria. Genetics. 1992 Jan; 130(1):27-36. PMID: 1732166; PMCID: PMC1204802.
      58. Fang FC, Helinski D. Broad-host-range properties of plasmid RK2: importance of overlapping genes encoding the plasmid replication initiation protein TrfA. J Bacteriol. 1991 Sep; 173(18):5861-8. PMID: 1885553; PMCID: PMC208320.
      59. Perri S, Helinski D, Toukdarian A. Interactions of plasmid-encoded replication initiation proteins with the origin of DNA replication in the broad host range plasmid RK2. J Biol Chem. 1991 Jul 05; 266(19):12536-43. PMID: 2061326.
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      60. Gilles-Gonzalez MA, Ditta GS, Helinski D. A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti. Nature. 1991 Mar 14; 350(6314):170-2. PMID: 1848683.
        View in: PubMed
      61. Valla S, Haugan K, Durland R, Helinski D. Isolation and properties of temperature-sensitive mutants of the trfA gene of the broad host range plasmid RK2. Plasmid. 1991 Mar; 25(2):131-6. PMID: 1857753.
        View in: PubMed
      62. Kittell BL, Helinski D. Iteron inhibition of plasmid RK2 replication in vitro: evidence for intermolecular coupling of replication origins as a mechanism for RK2 replication control. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1389-93. PMID: 1996339; PMCID: PMC51023.
      63. Roberts RC, Burioni R, Helinski D. Genetic characterization of the stabilizing functions of a region of broad-host-range plasmid RK2. J Bacteriol. 1990 Nov; 172(11):6204-16. PMID: 2121707; PMCID: PMC526801.
      64. Greener A, Filutowicz MS, McEachern MJ, Helinski D. N-terminal truncated forms of the bifunctional pi initiation protein express negative activity on plasmid R6K replication. Mol Gen Genet. 1990 Oct; 224(1):24-32. PMID: 2277631.
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      65. Durland RH, Toukdarian A, Fang F, Helinski D. Mutations in the trfA replication gene of the broad-host-range plasmid RK2 result in elevated plasmid copy numbers. J Bacteriol. 1990 Jul; 172(7):3859-67. PMID: 2193921; PMCID: PMC213367.
      66. Durland RH, Helinski D. Replication of the broad-host-range plasmid RK2: direct measurement of intracellular concentrations of the essential TrfA replication proteins and their effect on plasmid copy number. J Bacteriol. 1990 Jul; 172(7):3849-58. PMID: 2193920; PMCID: PMC213366.
      67. Dylan T, Helinski D, Ditta GS. Hypoosmotic adaptation in Rhizobium meliloti requires beta-(1----2)-glucan. J Bacteriol. 1990 Mar; 172(3):1400-8. PMID: 1689716; PMCID: PMC208612.
      68. Dylan T, Nagpal P, Helinski D, Ditta GS. Symbiotic pseudorevertants of Rhizobium meliloti ndv mutants. J Bacteriol. 1990 Mar; 172(3):1409-17. PMID: 2307652; PMCID: PMC208613.
      69. Ielpi L, Dylan T, Ditta GS, Helinski D, Stanfield SW. The ndvB locus of Rhizobium meliloti encodes a 319-kDa protein involved in the production of beta-(1----2)-glucan. J Biol Chem. 1990 Feb 15; 265(5):2843-51. PMID: 2154461.
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      70. Kittell BL, Helinski D, Ditta GS. Aromatic aminotransferase activity and indoleacetic acid production in Rhizobium meliloti. J Bacteriol. 1989 Oct; 171(10):5458-66. PMID: 2551887; PMCID: PMC210384.
      71. McEachern MJ, Bott MA, Tooker PA, Helinski D. Negative control of plasmid R6K replication: possible role of intermolecular coupling of replication origins. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7942-6. PMID: 2682632; PMCID: PMC298188.
      72. Palomares AJ, DeLuca MA, Helinski D. Firefly luciferase as a reporter enzyme for measuring gene expression in vegetative and symbiotic Rhizobium meliloti and other gram-negative bacteria. Gene. 1989 Sep 01; 81(1):55-64. PMID: 2680767.
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      73. Schmidhauser TJ, Bechhofer DH, Figurski DH, Helinski D. Host-specific effects of the korA-korB operon and oriT region on the maintenance of miniplasmid derivatives of broad host-range plasmid RK2. Plasmid. 1989 Mar; 21(2):99-112. PMID: 2740456.
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      74. Stanfield SW, Ielpi L, O'Brochta D, Helinski D, Ditta GS. The ndvA gene product of Rhizobium meliloti is required for beta-(1----2)glucan production and has homology to the ATP-binding export protein HlyB. J Bacteriol. 1988 Aug; 170(8):3523-30. PMID: 3042754; PMCID: PMC211323.
      75. Virts EL, Stanfield SW, Helinski D, Ditta GS. Common regulatory elements control symbiotic and microaerobic induction of nifA in Rhizobium meliloti. Proc Natl Acad Sci U S A. 1988 May; 85(9):3062-5. PMID: 2834732; PMCID: PMC280143.
      76. Schmidhauser TJ, Ditta G, Helinski D. Broad-host-range plasmid cloning vectors for gram-negative bacteria. Biotechnology. 1988; 10:287-332. PMID: 2850044.
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      77. Durland RH, Helinski D. The sequence encoding the 43-kilodalton trfA protein is required for efficient replication or maintenance of minimal RK2 replicons in Pseudomonas aeruginosa. Plasmid. 1987 Sep; 18(2):164-9. PMID: 2829253.
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      78. de Wet JR, Wood KV, DeLuca M, Helinski D, Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol. 1987 Feb; 7(2):725-37. PMID: 3821727; PMCID: PMC365129.
      79. Filutowicz M, McEachern MJ, Mukhopadhyay P, Greener A, Yang SL, Helinski D. DNA and protein interactions in the regulation of plasmid replication. J Cell Sci Suppl. 1987; 7:15-31. PMID: 3332651.
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      80. Filutowicz M, McEachern MJ, Helinski D. Positive and negative roles of an initiator protein at an origin of replication. Proc Natl Acad Sci U S A. 1986 Dec; 83(24):9645-9. PMID: 3540947; PMCID: PMC387197.
      81. Ow DW, DE Wet JR, Helinski D, Howell SH, Wood KV, Deluca M. Transient and stable expression of the firefly luciferase gene in plant cells and transgenic plants. Science. 1986 Nov 14; 234(4778):856-9. PMID: 17758108.
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      82. Mukhopadhyay P, Filutowicz M, Helinski D. Replication from one of the three origins of the plasmid R6K requires coupled expression of two plasmid-encoded proteins. J Biol Chem. 1986 Jul 15; 261(20):9534-9. PMID: 3013894.
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      83. Dylan T, Ielpi L, Stanfield S, Kashyap L, Douglas C, Yanofsky M, Nester E, Helinski D, Ditta G. Rhizobium meliloti genes required for nodule development are related to chromosomal virulence genes in Agrobacterium tumefaciens. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4403-7. PMID: 16593714.
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      84. Stanfield SW, Helinski D. Multiple mechanisms generate extrachromosomal circular DNA in Chinese hamster ovary cells. Nucleic Acids Res. 1986 Apr 25; 14(8):3527-38. PMID: 3010241; PMCID: PMC339791.
      85. Filutowicz M, Uhlenhopp E, Helinski D. Binding of purified wild-type and mutant pi initiation proteins to a replication origin region of plasmid R6K. J Mol Biol. 1986 Jan 20; 187(2):225-39. PMID: 3009827.
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      86. de Wet JR, Wood KV, Helinski D, DeLuca M. Cloning firefly luciferase. Methods Enzymol. 1986; 133:3-14. PMID: 3547031.
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      87. Kim CH, Helinski D, Ditta G. Overlapping transcription of the nifA regulatory gene in Rhizobium meliloti. Gene. 1986; 50(1-3):141-8. PMID: 3472992.
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      88. de Wet JR, Wood KV, Helinski D, DeLuca M. Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli. Proc Natl Acad Sci U S A. 1985 Dec; 82(23):7870-3. PMID: 3906652; PMCID: PMC390871.
      89. Stalker DM, Helinski D. DNA segments of the IncX plasmid R485 determining replication and incompatibility with plasmid R6K. Plasmid. 1985 Nov; 14(3):245-54. PMID: 3006104.
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      90. Better M, Ditta G, Helinski D. Deletion analysis of Rhizobium meliloti symbiotic promoters. EMBO J. 1985 Oct; 4(10):2419-24. PMID: 15929217; PMCID: PMC554523.
      91. Schmidhauser TJ, Helinski D. Regions of broad-host-range plasmid RK2 involved in replication and stable maintenance in nine species of gram-negative bacteria. J Bacteriol. 1985 Oct; 164(1):446-55. PMID: 4044529; PMCID: PMC214264.
      92. Chikami GK, Guiney DG, Schmidhauser TJ, Helinski D. Comparison of 10 IncP plasmids: homology in the regions involved in plasmid replication. J Bacteriol. 1985 May; 162(2):656-60. PMID: 2985542; PMCID: PMC218900.
      93. McEachern MJ, Filutowicz M, Helinski D. Mutations in direct repeat sequences and in a conserved sequence adjacent to the repeats result in a defective replication origin in plasmid R6K. Proc Natl Acad Sci U S A. 1985 Mar; 82(5):1480-4. PMID: 3883361; PMCID: PMC397286.
      94. Ditta G, Schmidhauser T, Yakobson E, Lu P, Liang XW, Finlay DR, Guiney D, Helinski D. Plasmids related to the broad host range vector, pRK290, useful for gene cloning and for monitoring gene expression. Plasmid. 1985 Mar; 13(2):149-53. PMID: 2987994.
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      95. Filutowicz M, Davis G, Greener A, Helinski D. Autorepressor properties of the pi-initiation protein encoded by plasmid R6K. Nucleic Acids Res. 1985 Jan 11; 13(1):103-14. PMID: 3923429; PMCID: PMC340977.
      96. Shafferman A, Helinski D. Transcription signals in a region essential for replication of plasmid R6K. Plasmid. 1985 Jan; 13(1):51-8. PMID: 3887441.
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      97. Filutowicz M, McEachern M, Greener A, Mukhopadhyay P, Uhlenhopp E, Durland R, Helinski D. Role of the pi initiation protein and direct nucleotide sequence repeats in the regulation of plasmid R6K replication. Basic Life Sci. 1985; 30:125-40. PMID: 2990404.
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      98. de Wet JR, Fukushima H, Dewji NN, Wilcox E, O'Brien JS, Helinski D. Chromogenic immunodetection of human serum albumin and alpha-L-fucosidase clones in a human hepatoma cDNA expression library. DNA. 1984 Dec; 3(6):437-47. PMID: 6096099.
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      99. Stanfield SW, Helinski D. Cloning and characterization of small circular DNA from Chinese hamster ovary cells. Mol Cell Biol. 1984 Jan; 4(1):173-80. PMID: 6700583; PMCID: PMC368672.
      100. Better M, Lewis B, Corbin D, Ditta G, Helinski D. Structural relationships among Rhizobium meliloti symbiotic promoters. Cell. 1983 Dec; 35(2 Pt 1):479-85. PMID: 6317191.
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      101. Stalker DM, Filutowicz M, Helinski D. Release of initiation control by a mutational alteration in the R6K pi protein required for plasmid DNA replication. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5500-4. PMID: 6310578; PMCID: PMC384285.
      102. Better M, Helinski D. Isolation and characterization of the recA gene of Rhizobium meliloti. J Bacteriol. 1983 Jul; 155(1):311-6. PMID: 6305915; PMCID: PMC217682.
      103. Schmidhauser TJ, Filutowicz M, Helinski D. Replication of derivatives of the broad host range plasmid RK2 in two distantly related bacteria. Plasmid. 1983 May; 9(3):325-30. PMID: 6346358.
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      104. Shafferman A, Helinski D. Structural properties of the beta origin of replication of plasmid R6K. J Biol Chem. 1983 Apr 10; 258(7):4083-90. PMID: 6300075.
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      105. Kolter R, Helinski D. Plasmid R6K DNA replication. II. Direct nucleotide sequence repeats are required for an active gamma-origin. J Mol Biol. 1982 Oct 15; 161(1):45-56. PMID: 6296394.
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      106. Shafferman A, Kolter R, Stalker D, Helinski D. Plasmid R6K DNA replication. III. Regulatory properties of the pi initiation protein. J Mol Biol. 1982 Oct 15; 161(1):57-76. PMID: 6818353.
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      107. Stalker DM, Kolter R, Helinski D. Plasmid R6K DNA replication. I. Complete nucleotide sequence of an autonomously replicating segment. J Mol Biol. 1982 Oct 15; 161(1):33-43. PMID: 6759660.
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      108. Leong SA, Ditta GS, Helinski D. Heme biosynthesis in Rhizobium. Identification of a cloned gene coding for delta-aminolevulinic acid synthetase from Rhizobium meliloti. J Biol Chem. 1982 Aug 10; 257(15):8724-30. PMID: 7096330.
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      109. Williams PH, Blair DG, Helinski D. Synthesis and repair of RNA-containing supercoiled plasmid ColE1 DNA in Escherichia coli. Plasmid. 1982 Mar; 7(2):180-91. PMID: 6177011.
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      110. Williams PH, Leavitt RW, Helinski D. Size and base composition of RNA segments in complementary strands of supercoiled plasmid ColE1 DNA. Plasmid. 1982 Mar; 7(2):192-5. PMID: 6177012.
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      111. Corbin D, Ditta G, Helinski D. Clustering of nitrogen fixation (nif) genes in Rhizobium meliloti. J Bacteriol. 1982 Jan; 149(1):221-8. PMID: 6274844; PMCID: PMC216613.
      112. Valentine RC, Rabson R, Sebek O, Helinski D. Roundtable discussion of research priorities. Basic Life Sci. 1982; 19:445-68. PMID: 7066013.
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      113. Helinski D. Plasmids as vectors for gene cloning: past, present, and future use. Basic Life Sci. 1982; 19:5-24. PMID: 6279087.
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      114. Tolun A, Helinski D. Separation of the minimal replication region of the F plasmid into a replication origin segment and a trans-acting segment. Mol Gen Genet. 1982; 186(3):372-7. PMID: 6750320.
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      115. Tolun A, Helinski D. Direct repeats of the F plasmid incC region express F incompatibility. Cell. 1981 Jun; 24(3):687-94. PMID: 7018695.
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      116. Thomas CM, Stalker DM, Helinski D. Replication and incompatibility properties of segments of the origin region of replication of the broad host range plasmid RK2. Mol Gen Genet. 1981; 181(1):1-7. PMID: 6261080.
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      117. Stalker DM, Thomas CM, Helinski D. Nucleotide sequence of the region of the origin of replication of the broad host range plasmid RK2. Mol Gen Genet. 1981; 181(1):8-12. PMID: 6261086.
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      118. Inuzuka N, Inuzuka M, Helinski D. Activity in vitro of three replication origins of the antibiotic resistance plasmid RSF1040. J Biol Chem. 1980 Dec 10; 255(23):11071-4. PMID: 6254956.
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      119. Ditta G, Stanfield S, Corbin D, Helinski D. Broad host range DNA cloning system for gram-negative bacteria: construction of a gene bank of Rhizobium meliloti. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7347-51. PMID: 7012838; PMCID: PMC350500.
      120. Thomas CM, Meyer R, Helinski D. Regions of broad-host-range plasmid RK2 which are essential for replication and maintenance. J Bacteriol. 1980 Jan; 141(1):213-22. PMID: 6243621; PMCID: PMC293566.
      121. Helinski D. Bacterial plasmids: autonomous replication and vehicles for gene cloning. CRC Crit Rev Biochem. 1979 Nov; 7(1):83-101. PMID: 115636.
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      122. Guiney DG, Helinski D. The DNA-protein relaxation complex of the plasmid RK2: location of the site-specific nick in the region of the proposed origin of transfer. Mol Gen Genet. 1979 Oct 03; 176(2):183-9. PMID: 393953.
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      123. Figurski DH, Meyer RJ, Helinski D. Suppression of Co1E1 replication properties by the Inc P-1 plasmid RK2 in hybrid plasmids constructed in vitro. J Mol Biol. 1979 Sep 25; 133(3):295-318. PMID: 395312.
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      124. Eichenlaub R, Sparks RB, Helinski D. Bidirectional replication of the mini-ColE1 plasmid pVH51. J Bacteriol. 1979 Apr; 138(1):257-60. PMID: 438132; PMCID: PMC218267.
      125. Figurski DH, Helinski D. Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1648-52. PMID: 377280; PMCID: PMC383447.
      126. Stalker DM, Kolter R, Helinski D. Nucleotide sequence of the region of an origin of replication of the antibiotic resistance plasmid R6K. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1150-4. PMID: 375227; PMCID: PMC383207.
      127. Sparks RB, Helinski D. Association of cellular membrane of E. coli minicells with the origins/terminus region of replication of plasmid ColEl DNA. Nature. 1979 Feb 15; 277(5697):572-4. PMID: 368651.
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      128. Bernard HU, Remaut E, Hershfield MV, Das HK, Helinski D, Yanofsky C, Franklin N. Construction of plasmid cloning vehicles that promote gene expression from the bacteriophage lambda pL promoter. Gene. 1979 Jan; 5(1):59-76. PMID: 372049.
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      129. Kahn ML, Figurski D, Ito L, Helinski D. Essential regions for replication of a stringent and a relaxed plasmid in Escherichia coli. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 1:99-103. PMID: 383389.
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      130. Bernard HU, Helinski D. Use of the lambda phage promoter PL to promote gene expression in hybrid plasmid cloning vehicles. Methods Enzymol. 1979; 68:482-92. PMID: 232223.
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      131. Kahn M, Kolter R, Thomas C, Figurski D, Meyer R, Remaut E, Helinski D. Plasmid cloning vehicles derived from plasmids ColE1, F, R6K, and RK2. Methods Enzymol. 1979; 68:268-80. PMID: 232215.
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      132. Kolter R, Inuzuka M, Figurski D, Thomas C, Stalker D, Helinski D. Plasmid DNA replication: RK2- and R6K-encoded trans-acting factors and their sites of action. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 1:91-7. PMID: 383388.
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      133. Kolter R, Helinski D. Regulation of initiation of DNA replication. Annu Rev Genet. 1979; 13:355-91. PMID: 395895.
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      134. Kolter R, Inuzuka M, Helinski D. Trans-complementation-dependent replication of a low molecular weight origin fragment from plasmid R6K. Cell. 1978 Dec; 15(4):1199-208. PMID: 728998.
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      135. Collins J, Yanofsky S, Helinski D. Altered DNA-protein relaxation complex in a replication mutant of plasmid ColE1. Mol Gen Genet. 1978 Nov 16; 167(1):21-8. PMID: 368585.
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      136. Inuzuka M, Helinski D. Requirement of a plasmid-encoded protein for replication in vitro of plasmid R6K. Proc Natl Acad Sci U S A. 1978 Nov; 75(11):5381-5. PMID: 364478; PMCID: PMC392967.
      137. Kolter R, Helinski D. Activity of the replication terminus of plasmid R6K in hybrid replicons in Escherichia coli. J Mol Biol. 1978 Sep 25; 124(3):425-41. PMID: 361971.
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      138. Kolter R, Helinski D. Construction of plasmid R6K derivatives in vitro: characterization of the R6K replication region. Plasmid. 1978 Sep; 1(4):571-80. PMID: 372982.
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      139. Inuzuka M, Helinski D. Replication of antibiotic resistance plasmid R6K DNA in vitro. Biochemistry. 1978 Jun 27; 17(13):2567-73. PMID: 354690.
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      140. Kahn M, Helinski D. Construction of a novel plasmid-phage hybrid: use of the hybrid to demonstrate ColE1 DNA replication in vivo in the absence of a ColE1-specified protein. Proc Natl Acad Sci U S A. 1978 May; 75(5):2200-4. PMID: 276860; PMCID: PMC392519.
      141. Meyer RJ, Helinski D. Unidirectional replication of the P-group plasmid RK2. Biochim Biophys Acta. 1977 Sep 06; 478(1):109-13. PMID: 329885.
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      142. Meyer R, Figurski D, Helinski D. Physical and genetic studies with restriction endonucleases on the broad host-range plasmid RK2. Mol Gen Genet. 1977 Apr 29; 152(3):129-35. PMID: 327269.
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      143. Katz L, Williams PH, Sato S, Leavitt RW, Helinski D. Purification and characterization of covalently closed replicative intermediates of ColEl DNA from Escherichia coli. Biochemistry. 1977 Apr 19; 16(8):1677-83. PMID: 322703.
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      144. Armstrong KA, Hershfield V, Helinski D. Gene cloning and containment properties of plasmid Col E1 and its derivatives. Science. 1977 Apr 08; 196(4286):172-4. PMID: 322277.
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      145. Eichenlaub R, Figurski D, Helinski D. Bidirection replication from a unique origin in a mini-F plasmid. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):1138-41. PMID: 322144; PMCID: PMC430623.
      146. Helinski D. Plasmids as vectors for gene cloning. Basic Life Sci. 1977; 9:19-49. PMID: 336024.
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      147. Stanfield S, Helinski D. Small circular DNA in Drosophila melanogaster. Cell. 1976 Oct; 9(2):333-45. PMID: 824055.
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      148. Lovett MA, Helinski D. Method for the isolation of the replication region of a bacterial replicon: construction of a mini-F'kn plasmid. J Bacteriol. 1976 Aug; 127(2):982-7. PMID: 783124; PMCID: PMC233008.
      149. Helinski D. Plasmid DNA replication. Fed Proc. 1976 Jul; 35(9):2026-30. PMID: 776703.
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      150. Helinski D. Plasmids: introductory remarks. Fed Proc. 1976 Jul; 35(9):2024-5. PMID: 1064555.
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      151. Helinski D. R factors. Science. 1976 May 21; 192(4241):778. PMID: 17777179.
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      152. Hershfield V, Boyer HW, Chow L, Helinski D. Characterization of a mini-ColC1 plasmid. J Bacteriol. 1976 Apr; 126(1):447-53. PMID: 770430; PMCID: PMC233301.
      153. Figurski D, Meyer R, Miller DS, Helinski D. Generation in vitro of deletions in the broad host range plasmid RK2 using phage Mu insertions and a restriction endonuclease. Gene. 1976; 1(1):107-19. PMID: 1052320.
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      154. Meyer R, Figurski D, Helinski D. Molecular vehicle properties of the broad host range plasmid RK2. Science. 1975 Dec 19; 190(4220):1226-8. PMID: 1060178.
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      155. Blair DG, Helinski D. Relaxation complexes of plasmid DNA and protein. I. Strand-specific association of protein and DNA in the relaxed complexes of plasmids ColE1 and ColE2. J Biol Chem. 1975 Nov 25; 250(22):8785-9. PMID: 1102543.
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      156. Lovett MA, Helinski D. Relaxation complexes of plasmid DNA and protein. II. Characterization of the proteins associated with the unrelaxed and relaxed complexes of plasmid ColE1. J Biol Chem. 1975 Nov 25; 250(22):8790-5. PMID: 1102544.
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      157. Guiney DG, Helinski D. Relaxation complexes of poasmid DNA and protein. III. Association of protein with the 5' terminus of the broken DNA strand in the relaxed complex of plasmid ColE1. J Biol Chem. 1975 Nov 25; 250(22):8796-803. PMID: 1102545.
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      158. Lovett MA, Sparks RB, Helinski D. Bidirectional replication of plasmid R6K DNA in Escherichia coli; correspondence between origin of replication and position of single-strand break in relaxed complex. Proc Natl Acad Sci U S A. 1975 Aug; 72(8):2905-9. PMID: 1103126; PMCID: PMC432887.
      159. Collins J, Williams P, Helinski D. Plasmid ColE1 DNA replication in Escherichia coli strains temperature-sensitive for DNA replication. Mol Gen Genet. 1975; 136(4):273-89. PMID: 16094996.
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      160. Kupersztoch-Portnoy YM, Lovett MA, Helinski D. Strand and site specificity of the relaxation event for the relaxation complex of the antibiotic resistance plasmid R6K. Biochemistry. 1974 Dec 31; 13(27):5484-90. PMID: 4616719.
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      161. Kupersztoch-Portroy YM, Helinski D. Breaks induced in supercoiled colicinogenic factor E1 DNA as a result of the decay of incorporated tritium. Biochim Biophys Acta. 1974 Dec 20; 374(3):316-23. PMID: 4433599.
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      162. Kupersztoch-Portnoy YM, Miklos GL, Helinski D. Properties of the relaxation complexes of supercoiled deoxyribonucleic acid and protein of the R plasmids R64, R28K, and R6K. J Bacteriol. 1974 Oct; 120(1):545-8. PMID: 4608091; PMCID: PMC245799.
      163. Lovett MA, Guiney DG, Helinski D. Relaxation complexes of plasmids ColE1 and ColE2: unique site of the nick in the open circular DNA of the relaxed complexes. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):3854-7. PMID: 4610563; PMCID: PMC434282.
      164. Lovett MA, Katz L, Helinski D. Unidirectional replication of plasmid ColE1 DNA. Nature. 1974 Sep 27; 251(5473):337-40. PMID: 4610399.
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      165. Hershfield V, Boyer HW, Yanofsky C, Lovett MA, Helinski D. Plasmid ColEl as a molecular vehicle for cloning and amplification of DNA. Proc Natl Acad Sci U S A. 1974 Sep; 71(9):3455-9. PMID: 4610576; PMCID: PMC433792.
      166. Katz L, Helinski D. Effect of inhibitors of ribonucleic acid and protein synthesis on the cyclic adenosine monophosphate stimulation of plasmid ColE1 replication. J Bacteriol. 1974 Aug; 119(2):450-60. PMID: 4368626; PMCID: PMC245627.
      167. Kupersztoch YM, Helinski D. A catenated DNA molecule as an intermediate in the replication of the resistance transfer factor R6K in Escherichia coli. Biochem Biophys Res Commun. 1973 Oct 15; 54(4):1451-9. PMID: 4585292.
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      168. Helinski D, Cohen SN, Tomoeda M. Bacterial plasmids. Science. 1973 Aug 03; 181(4098):471-2. PMID: 17793339.
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      169. Sherratt DJ, Helinski D. Replication of colicinogenic factor E1 in Escherichia coli. Properties of newly replicated supercoils. Eur J Biochem. 1973 Aug 01; 37(1):95-9. PMID: 4580886.
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      170. Kingsbury DT, Helinski D. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli: requirement for deoxyribonucleic acid polymerase I in the replication of the plasmid ColE 1 . J Bacteriol. 1973 Jun; 114(3):1116-24. PMID: 4576398; PMCID: PMC285372.
      171. Kingsbury DT, Helinski D. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli. I. Isolation and specificity of host and plasmid mutations. Genetics. 1973 May; 74(1):17-31. PMID: 4576229; PMCID: PMC1212933.
      172. Kingsbury DT, Sieckmann DG, Helinski D. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli. II. Properties of host and plasmid mutations. Genetics. 1973 May; 74(1):1-16. PMID: 4576230; PMCID: PMC1212927.
      173. Katz L, Kingsbury DT, Helinski D. Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex. J Bacteriol. 1973 May; 114(2):577-91. PMID: 4350343; PMCID: PMC251812.
      174. Helinski D, Blair DG, Sherratt DJ, Lovett M, Kupersztoch Y, Kingsbury DT. Replication of plasmid supercoiled DNA. Johns Hopkins Med J Suppl. 1973; 2:15-34. PMID: 4607019.
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      175. Helinski D. Plasmid determined resistance to antibiotics: molecular properties of R factors. Annu Rev Microbiol. 1973; 27:437-70. PMID: 4584692.
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      176. Blair DG, Sherratt DJ, Clewell DB, Helinski D. Isolation of supercoiled colicinogenic factor E 1 DNA sensitive to ribonuclease and alkali. Proc Natl Acad Sci U S A. 1972 Sep; 69(9):2518-22. PMID: 4560690; PMCID: PMC426978.
      177. Clewell DB, Helinski D. Effect of growth conditions on the formation of the relaxation complex of supercoiled ColE1 deoxyribonucleic acid and protein in Escherichia coli. J Bacteriol. 1972 Jun; 110(3):1135-46. PMID: 4555406; PMCID: PMC247537.
      178. Kline BC, Helinski D. F 1 sex factor of Escherichia coli. Size and purification in the form of a strand-specific relaxation complex of supercoiled deoxyribonucleic acid and protein. Biochemistry. 1971 Dec 21; 10(26):4975-80. PMID: 4944065.
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      179. Schwartz SA, Helinski D. Purification and characterization of colicin E1. J Biol Chem. 1971 Oct 25; 246(20):6318-27. PMID: 5001789.
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      180. Goebel W, Helinski D. Endonuclease I of Proteus mirabilis. Purification and demonstration of limited endonuclease activity. J Biol Chem. 1971 Jun 25; 246(12):3851-6. PMID: 5561464.
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      181. Goebel W, Helinski D. Endonuclease I of Proteus mirabilis. Properties of the noncomplexed and transfer ribonucleic acid-complexed forms of the enzyme. J Biol Chem. 1971 Jun 25; 246(12):3857-62. PMID: 4327190.
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      182. Helinski D, Clewell DB. Circular DNA. Annu Rev Biochem. 1971; 40:899-942. PMID: 4942224.
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      183. Blair DG, Clewell DB, Sheratt DJ, Helinski D. Strand-specific supercoiled DNA-protein relaxation complexes: comparison of the complexes of bacterial plasmids ColE1 and ColE2. Proc Natl Acad Sci U S A. 1971 Jan; 68(1):210-4. PMID: 4924969; PMCID: PMC391197.
      184. Kingsbury DT, Helinski D. DNA polymerase as a requirement for the maintenance of the bacterial plasmid colicinogenic factor E1. Biochem Biophys Res Commun. 1970 Dec 24; 41(6):1538-44. PMID: 4922634.
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      185. Goebel W, Helinski D. Nicking activity of an endonuclease. I. Transfer ribonucleic acid complex of Escherichia coli. Biochemistry. 1970 Nov 24; 9(24):4793-801. PMID: 4991605.
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      186. Clewell DB, Helinski D. Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event. Biochemistry. 1970 Oct 27; 9(22):4428-40. PMID: 4919547.
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      187. Clewell DB, Helinski D. Evidence for the existence of the colicinogenic factors E2 and E3 as supercoiled circular DNA-protein relaxation complexes. Biochem Biophys Res Commun. 1970 Aug 11; 40(3):608-13. PMID: 4923716.
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      188. Bazaral M, Helinski D. Replication of a bacterial plasmid and an episome in Escherichia coli. Biochemistry. 1970 Jan 20; 9(2):399-406. PMID: 4904868.
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      189. Carlton BC, Helinski D. Heterogeneous circular DNA elements in vegetative cultures of Bacillus megaterium. Proc Natl Acad Sci U S A. 1969 Oct; 64(2):592-9. PMID: 4982358; PMCID: PMC223385.
      190. Clewell DB, Helinski D. Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form. Proc Natl Acad Sci U S A. 1969 Apr; 62(4):1159-66. PMID: 4894690; PMCID: PMC223628.
      191. Goebel W, Helinski D. Generation of higher multiple circular DNA forms in bacteria. Proc Natl Acad Sci U S A. 1968 Dec; 61(4):1406-13. PMID: 4884687; PMCID: PMC225270.
      192. Bazaral M, Helinski D. Characterization of multiple circular DNA forms of colicinogenic factor E-1 from Proteus mirabilis. Biochemistry. 1968 Oct; 7(10):3513-20. PMID: 4878700.
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      193. Bazaral M, Helinski D. Circular DNA forms of colicinogenic factors E1, E2 and E3 from Escherichia coli. J Mol Biol. 1968 Sep 14; 36(2):185-94. PMID: 4939624.
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      194. Herschman HR, Helinski D. Purification and characterization of colicin E2 and colicin E3. J Biol Chem. 1967 Nov 25; 242(22):5360-8. PMID: 4965137.
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      195. Hickson FT, Roth TF, Helinski D. Circular DNA forms of a bacterial sex factor. Proc Natl Acad Sci U S A. 1967 Oct; 58(4):1731-8. PMID: 5237898; PMCID: PMC223987.
      196. Herschman HR, Helinski D. Comparative study of the events associated with colicin induction. J Bacteriol. 1967 Sep; 94(3):691-9. PMID: 5340680; PMCID: PMC251940.
      197. Helinski D, Herschman HR. Effect of Rec mutations on the activity of colicinogenic factors. J Bacteriol. 1967 Sep; 94(3):700-6. PMID: 5340681; PMCID: PMC251941.
      198. Roth TF, Helinski D. Evidence for circular DNA forms of a bacterial plasmid. Proc Natl Acad Sci U S A. 1967 Aug; 58(2):650-7. PMID: 5233464; PMCID: PMC335684.
      199. Creighton TE, Helinski D, Somerville RL, Yanofsky C. Comparison of the tryptophan synthetase alpha-subunits of several species of Enterobacteriaceae. J Bacteriol. 1966 May; 91(5):1819-26. PMID: 5327908; PMCID: PMC316128.
      200. Kahn PL, Helinski D. Interaction between colicinogenic factor V and the integrated F factor in an Hfr strain of Escherichia coli. J Bacteriol. 1965 Nov; 90(5):1276-82. PMID: 5321482; PMCID: PMC315813.
      201. KAHN P, HELINSKI DR. RELATIONSHIP BETWEEN COLICINOGENIC FACTORS E1 AND V AND AN F FACTOR IN ESCHERICHIA COLI. J Bacteriol. 1964 Dec; 88:1573-9. PMID: 14240939; PMCID: PMC277454.
      202. YANOFSKY C, CARLTON BC, GUEST JR, HELINSKI DR, HENNING U. ON THE COLINEARITY OF GENE STRUCTURE AND PROTEIN STRUCTURE. Proc Natl Acad Sci U S A. 1964 Feb; 51:266-72. PMID: 14124325; PMCID: PMC300060.
      203. HELINSKI DR, YANOFSKY C. A genetic and biochemical analysis of second site reversion. J Biol Chem. 1963 Mar; 238:1043-8. PMID: 13953567.
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      204. YANOFSKY C, HENNING U, HELINSKI D, CARLTON B. Mutational alteration of protein structure. Fed Proc. 1963 Jan-Feb; 22:75-9. PMID: 14002474.
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      205. HELINSKI DR, YANOFSKY C. Peptide pattern studies on the wild-type A protein of the tryptophan synthetase of Escherichia coli. Biochim Biophys Acta. 1962 Sep 10; 63:10-9. PMID: 13953568.
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      206. HENNING U, HELINSKI DR, CHAO FC, YANOFSKY C. The A protein of the tryptophan synthetase of Escherichia coli. Purification, crystallization, and composition studies. J Biol Chem. 1962 May; 237:1523-30. PMID: 13906502.
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      207. HELINSKI DR, YANOFSKY C. Correspondence between genetic data and the position of amino acid alteration in a proein. Proc Natl Acad Sci U S A. 1962 Feb; 48:173-83. PMID: 13906211; PMCID: PMC220753.
      208. YANOFSKY C, HELINSKI DR, MALING BD. The effects of mutation on the composition and properties of the A protein of Escherichia coli tryptohan synthetase. Cold Spring Harb Symp Quant Biol. 1961; 26:11-24. PMID: 14008999.
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      209. HELINSKI DR, COOPER C. Studies on the action of bovine serum albumin on aged rat livermitochondria. J Biol Chem. 1960 Dec; 235:3573-9. PMID: 13713081.
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