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Donald Helinski

Title(s)Emeritus Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #0322
La Jolla CA 92093
Phone8/5-34--3638
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    Collapse Research 
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    Structure and Genetic Control of Colicines
    NIH/NIAID R01AI007194Feb 1, 1978 - May 31, 2001
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Farewell Stan Stanley Falkow: 1934-2018. Environ Microbiol. 2018 Jul; 20(7):2322-2333. Cabello FC, Cohen SN, Curtiss R, Dougan G, van Embden J, Finlay BB, Heffron F, Helinski D, Hull R, Hull S, Isberg R, Kopecko DJ, Levy S, Mekalanos J, Ortiz JM, Rappuoli R, Roberts MC, So M, Timmis KN. PMID: 30146753.
      View in: PubMed   Mentions:    Fields:    
    2. The incC korB region of RK2 repositions a mini-RK2 replicon in Escherichia coli. Plasmid. 2007 Sep; 58(2):195-204. Verheust C, Helinski DR. PMID: 17521722.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    3. Localization of the naturally occurring plasmid ColE1 at the cell pole. J Bacteriol. 2007 Mar; 189(5):1946-53. Yao S, Helinski DR, Toukdarian A. PMID: 17158664.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    4. Inhibition of protein and RNA synthesis in Escherichia coli results in declustering of plasmid RK2. Plasmid. 2006 Sep; 56(2):124-32. Yao S, Toukdarian A, Helinski DR. PMID: 16774785.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    5. Functional analysis of two putative chromosomal replication origins from Pseudomonas aeruginosa. Plasmid. 2006 May; 55(3):194-200. Jiang Y, Yao S, Helinski D, Toukdarian A. PMID: 16376988.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    6. Gyrase inhibitors and thymine starvation disrupt the normal pattern of plasmid RK2 localization in Escherichia coli. J Bacteriol. 2005 May; 187(10):3538-47. Johnson EP, Yao S, Helinski DR. PMID: 15866942.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Plasmid host-range: restrictions to F replication in Pseudomonas. Plasmid. 2005 Jul; 54(1):48-56. Zhong Z, Helinski D, Toukdarian A. PMID: 15907538.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    8. A pilot study of orlistat treatment in obese, non-alcoholic steatohepatitis patients. Aliment Pharmacol Ther. 2004 Sep 15; 20(6):623-8. Harrison SA, Fincke C, Helinski D, Torgerson S, Hayashi P. PMID: 15352910.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    9. A specific region in the N terminus of a replication initiation protein of plasmid RK2 is required for recruitment of Pseudomonas aeruginosa DnaB helicase to the plasmid origin. J Biol Chem. 2003 Nov 14; 278(46):45305-10. Zhong Z, Helinski D, Toukdarian A. PMID: 12952979.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    10. A multifunctional plasmid-encoded replication initiation protein both recruits and positions an active helicase at the replication origin. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8692-7. Jiang Y, Pacek M, Helinski DR, Konieczny I, Toukdarian A. PMID: 12835421.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    11. Nucleotide sequence based characterizations of two cryptic plasmids from the marine bacterium Ruegeria isolate PR1b. Plasmid. 2003 May; 49(3):233-52. Zhong Z, Caspi R, Helinski D, Knauf V, Sykes S, O'Byrne C, Shea TP, Wilkinson JE, DeLoughery C, Toukdarian A. PMID: 12749836.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    12. ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase. Mol Microbiol. 2002 May; 44(4):971-9. Jiang Y, Pogliano J, Helinski DR, Konieczny I. PMID: 12010492.
      View in: PubMed   Mentions: 99     Fields:    Translation:Cells
    13. A 50-kb plasmid rich in mobile gene sequences isolated from a marine micrococcus. Plasmid. 2002 Jan; 47(1):1-9. Zhong Z, Caspi R, Mincer T, Helinski D, Knauf V, Boardman K, Wilkinson JE, Shea T, DeLoughery C, Toukdarian A. PMID: 11798280.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    14. Sequence analysis of a 101-kilobase plasmid required for agar degradation by a Microscilla isolate. Appl Environ Microbiol. 2001 Dec; 67(12):5771-9. Zhong Z, Toukdarian A, Helinski D, Knauf V, Sykes S, Wilkinson JE, O'Bryne C, Shea T, DeLoughery C, Caspi R. PMID: 11722934.
      View in: PubMed   Mentions: 12     Fields:    Translation:CellsPHPublic Health
    15. A broad host range replicon with different requirements for replication initiation in three bacterial species. EMBO J. 2001 Jun 15; 20(12):3262-71. Caspi R, Pacek M, Consiglieri G, Helinski DR, Toukdarian A, Konieczny I. PMID: 11406602.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    16. Multicopy plasmids are clustered and localized in Escherichia coli. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4486-91. Pogliano J, Ho TQ, Zhong Z, Helinski DR. PMID: 11274369.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    17. Regulation of the switch from early to late bacteriophage lambda DNA replication. Microbiology (Reading). 2001 Mar; 147(Pt 3):535-547. Baranska S, Gabig M, Wegrzyn A, Konopa G, Herman-Antosiewicz A, Hernandez P, Schvartzman JB, Helinski DR, Wegrzyn G. PMID: 11238961.
      View in: PubMed   Mentions:
    18. Interactions of DnaA proteins from distantly related bacteria with the replication origin of the broad host range plasmid RK2. J Biol Chem. 2000 Jun 16; 275(24):18454-61. Caspi R, Helinski DR, Pacek M, Konieczny I. PMID: 10749858.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    19. Plasmid RK2 ParB protein: purification and nuclease properties. J Bacteriol. 1999 Oct; 181(19):6010-8. Johnson EP, Mincer T, Schwab H, Burgin AB, Helinski DR. PMID: 10498713.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    20. Host-dependent requirement for specific DnaA boxes for plasmid RK2 replication. Mol Microbiol. 1999 Aug; 33(3):490-8. Doran KS, Helinski DR, Konieczny I. PMID: 10417640.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    21. A critical DnaA box directs the cooperative binding of the Escherichia coli DnaA protein to the plasmid RK2 replication origin. J Biol Chem. 1999 Jun 18; 274(25):17918-23. Doran KS, Helinski DR, Konieczny I. PMID: 10364238.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    22. TrfA dimers play a role in copy-number control of RK2 replication. Gene. 1998 Nov 26; 223(1-2):205-11. Toukdarian AE, Helinski DR. PMID: 9858734.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    23. Role of the parCBA operon of the broad-host-range plasmid RK2 in stable plasmid maintenance. J Bacteriol. 1998 Nov; 180(22):6023-30. Easter CL, Schwab H, Helinski DR. PMID: 9811663.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    24. Escherichia coli dnaA gene function and bacteriophage lambda replication. FEMS Microbiol Lett. 1998 Oct 01; 167(1):27-32. Szalewska-Palasz A, Lemieszek E, Pankiewicz A, Wegrzyn A, Helinski DR, Wegrzyn G. PMID: 9785448.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    25. Isolation of broad-host-range replicons from marine sediment bacteria. Appl Environ Microbiol. 1998 Aug; 64(8):2822-30. Sobecky PA, Mincer TJ, Chang MC, Toukdarian A, Helinski DR. PMID: 9687436.
      View in: PubMed   Mentions: 12     Fields:    Translation:CellsPHPublic Health
    26. Replication origin of the broad host range plasmid RK2. Positioning of various motifs is critical for initiation of replication. J Biol Chem. 1998 Apr 03; 273(14):8447-53. Doran KS, Konieczny I, Helinski DR. PMID: 9525957.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    27. Helicase delivery and activation by DnaA and TrfA proteins during the initiation of replication of the broad host range plasmid RK2. J Biol Chem. 1997 Dec 26; 272(52):33312-8. Konieczny I, Helinski DR. PMID: 9407123.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    28. The replication initiation protein of the broad-host-range plasmid RK2 is activated by the ClpX chaperone. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14378-82. Konieczny I, Helinski DR. PMID: 9405620.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    29. Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2. J Bacteriol. 1997 Oct; 179(20):6472-9. Easter CL, Sobecky PA, Helinski DR. PMID: 9335298.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    30. Role of TrfA and DnaA proteins in origin opening during initiation of DNA replication of the broad host range plasmid RK2. J Biol Chem. 1997 Aug 08; 272(32):20173-8. Konieczny I, Doran KS, Helinski DR, Blasina A. PMID: 9242693.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    31. Plasmids isolated from marine sediment microbial communities contain replication and incompatibility regions unrelated to those of known plasmid groups. Appl Environ Microbiol. 1997 Mar; 63(3):888-95. Sobecky PA, Mincer TJ, Chang MC, Helinski DR. PMID: 9055407.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    32. Copy-up mutants of the plasmid RK2 replication initiation protein are defective in coupling RK2 replication origins. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3559-64. Blasina A, Kittell BL, Toukdarian AE, Helinski DR. PMID: 8622975.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    33. Characterization of the stable maintenance properties of the par region of broad-host-range plasmid RK2. J Bacteriol. 1996 Apr; 178(7):2086-93. Sobecky PA, Easter CL, Bear PD, Helinski DR. PMID: 8606188.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    34. The plasmid RK2 initiation protein binds to the origin of replication as a monomer. J Biol Chem. 1996 Mar 22; 271(12):7072-8. Toukdarian AE, Helinski DR, Perri S. PMID: 8636140.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    35. Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein. J Bacteriol. 1996 Mar; 178(5):1420-9. Johnson EP, Strom AR, Helinski DR. PMID: 8631720.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    36. Different relative importances of the par operons and the effect of conjugal transfer on the maintenance of intact promiscuous plasmid RK2. J Bacteriol. 1995 May; 177(10):2789-97. Sia EA, Roberts RC, Easter C, Helinski DR, Figurski DH. PMID: 7751288.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    37. Involvement of the host initiator function dnaA in the replication of coliphage lambda. Genetics. 1995 Apr; 139(4):1469-81. Wegrzyn G, Wegrzyn A, Konieczny I, Bielawski K, Konopa G, Obuchowski M, Helinski DR, Taylor K. PMID: 7789753.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    38. The oxygen sensor protein, FixL, of Rhizobium meliloti. Role of histidine residues in heme binding, phosphorylation, and signal transduction. J Biol Chem. 1995 Mar 10; 270(10):5243-50. Monson EK, Ditta GS, Helinski DR. PMID: 7890634.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    39. Complete nucleotide sequence of Birmingham IncP alpha plasmids. Compilation and comparative analysis. J Mol Biol. 1994 Jun 24; 239(5):623-63. Pansegrau W, Lanka E, Barth PT, Figurski DH, Guiney DG, Haas D, Helinski DR, Schwab H, Stanisich VA, Thomas CM. PMID: 8014987.
      View in: PubMed   Mentions: 164     Fields:    Translation:Cells
    40. Oxygen regulation of expression of nitrogen fixation genes in Rhizobium meliloti. Res Microbiol. 1994 Jun-Aug; 145(5-6):454-9. Agron PG, Monson EK, Ditta GS, Helinski DR. PMID: 7855432.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    41. The parDE operon of the broad-host-range plasmid RK2 specifies growth inhibition associated with plasmid loss. J Mol Biol. 1994 Mar 18; 237(1):35-51. Roberts RC, Ström AR, Helinski DR. PMID: 8133518.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    42. Isolation and characterization of DNA-binding mutants of a plasmid replication initiation protein utilizing an in vivo binding assay. Plasmid. 1994 Jan; 31(1):89-99. Cereghino JL, Helinski DR, Toukdarian AE. PMID: 8171128.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    43. Characteristics and significance of DNA binding activity of plasmid stabilization protein ParD from the broad host-range plasmid RK2. J Biol Chem. 1993 Dec 25; 268(36):27109-17. Roberts RC, Spangler C, Helinski DR. PMID: 8262949.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    44. Mutants of the two-component regulatory protein FixJ of Rhizobium meliloti that have increased activity at the nifA promoter. Gene. 1993 Dec 08; 134(2):145-52. Weinstein M, Lois AF, Ditta GS, Helinski DR. PMID: 8262372.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    45. Essentiality of the three carboxyl-terminal amino acids of the plasmid RK2 replication initiation protein TrfA for DNA binding and replication activity in gram-negative bacteria. J Biol Chem. 1993 Nov 25; 268(33):24926-32. Cereghino JL, Helinski DR. PMID: 8227054.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    46. Mutations in the gene encoding the replication-initiation protein of plasmid RK2 produce elevated copy numbers of RK2 derivatives in Escherichia coli and distantly related bacteria. Gene. 1993 Oct 29; 133(1):1-8. Fang FC, Durland RH, Helinski DR. PMID: 8224880.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    47. Oxygen regulation of nifA transcription in vitro. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3506-10. Agron PG, Ditta GS, Helinski DR. PMID: 8475099.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    48. Autophosphorylation and phosphatase activities of the oxygen-sensing protein FixL of Rhizobium meliloti are coordinately regulated by oxygen. J Biol Chem. 1993 Feb 25; 268(6):4370-5. Lois AF, Weinstein M, Ditta GS, Helinski DR. PMID: 8382700.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    49. DNA sequence requirements for interaction of the RK2 replication initiation protein with plasmid origin repeats. J Biol Chem. 1993 Feb 15; 268(5):3662-9. Perri S, Helinski DR. PMID: 8429042.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    50. The oxygen sensor FixL of Rhizobium meliloti is a membrane protein containing four possible transmembrane segments. J Bacteriol. 1993 Feb; 175(4):1103-9. Lois AF, Ditta GS, Helinski DR. PMID: 8432704.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    51. Definition of a minimal plasmid stabilization system from the broad-host-range plasmid RK2. J Bacteriol. 1992 Dec; 174(24):8119-32. Roberts RC, Helinski DR. PMID: 1459960.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    52. A region of the broad-host-range plasmid RK2 causes stable in planta inheritance of plasmids in Rhizobium meliloti cells isolated from alfalfa root nodules. J Bacteriol. 1992 Nov; 174(22):7486-9. Weinstein M, Roberts RC, Helinski DR. PMID: 1429472.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    53. Isolation of phosphorylation-deficient mutants of the Rhizobium meliloti two-component regulatory protein, FixJ. Mol Microbiol. 1992 Aug; 6(15):2041-9. Weinstein M, Lois AF, Monson EK, Ditta GS, Helinski DR. PMID: 1406247.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    54. Transcription and autoregulation of the stabilizing functions of broad-host-range plasmid RK2 in Escherichia coli, Agrobacterium tumefaciens and Pseudomonas aeruginosa. Mol Microbiol. 1992 Jul; 6(14):1981-94. Davis TL, Helinski DR, Roberts RC. PMID: 1508045.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    55. Analysis of mutations in trfA, the replication initiation gene of the broad-host-range plasmid RK2. J Bacteriol. 1992 Jun; 174(12):4110-9. Lin J, Helinski DR. PMID: 1597426.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    56. Mutational analysis of the Rhizobium meliloti nifA promoter. J Bacteriol. 1992 Jun; 174(12):4120-9. Agron PG, Ditta GS, Helinski DR. PMID: 1597427.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    57. The FixL protein of Rhizobium meliloti can be separated into a heme-binding oxygen-sensing domain and a functional C-terminal kinase domain. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4280-4. Monson EK, Weinstein M, Ditta GS, Helinski DR. PMID: 1584762.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    58. Promoters of the broad host range plasmid RK2: analysis of transcription (initiation) in five species of gram-negative bacteria. Genetics. 1992 Jan; 130(1):27-36. Greener A, Lehman SM, Helinski DR. PMID: 1732166.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    59. Broad-host-range properties of plasmid RK2: importance of overlapping genes encoding the plasmid replication initiation protein TrfA. J Bacteriol. 1991 Sep; 173(18):5861-8. Fang FC, Helinski DR. PMID: 1885553.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    60. Interactions of plasmid-encoded replication initiation proteins with the origin of DNA replication in the broad host range plasmid RK2. J Biol Chem. 1991 Jul 05; 266(19):12536-43. Perri S, Helinski DR, Toukdarian A. PMID: 2061326.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    61. A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti. Nature. 1991 Mar 14; 350(6314):170-2. Gilles-Gonzalez MA, Ditta GS, Helinski DR. PMID: 1848683.
      View in: PubMed   Mentions: 120     Fields:    Translation:Cells
    62. Isolation and properties of temperature-sensitive mutants of the trfA gene of the broad host range plasmid RK2. Plasmid. 1991 Mar; 25(2):131-6. Valla S, Haugan K, Durland R, Helinski DR. PMID: 1857753.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    63. Iteron inhibition of plasmid RK2 replication in vitro: evidence for intermolecular coupling of replication origins as a mechanism for RK2 replication control. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1389-93. Kittell BL, Helinski DR. PMID: 1996339.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    64. Genetic characterization of the stabilizing functions of a region of broad-host-range plasmid RK2. J Bacteriol. 1990 Nov; 172(11):6204-16. Roberts RC, Burioni R, Helinski DR. PMID: 2121707.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    65. N-terminal truncated forms of the bifunctional pi initiation protein express negative activity on plasmid R6K replication. Mol Gen Genet. 1990 Oct; 224(1):24-32. Greener A, Filutowicz MS, McEachern MJ, Helinski DR. PMID: 2277631.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    66. Replication of the broad-host-range plasmid RK2: direct measurement of intracellular concentrations of the essential TrfA replication proteins and their effect on plasmid copy number. J Bacteriol. 1990 Jul; 172(7):3849-58. Durland RH, Helinski DR. PMID: 2193920.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    67. Mutations in the trfA replication gene of the broad-host-range plasmid RK2 result in elevated plasmid copy numbers. J Bacteriol. 1990 Jul; 172(7):3859-67. Durland RH, Toukdarian A, Fang F, Helinski DR. PMID: 2193921.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    68. Hypoosmotic adaptation in Rhizobium meliloti requires beta-(1----2)-glucan. J Bacteriol. 1990 Mar; 172(3):1400-8. Dylan T, Helinski DR, Ditta GS. PMID: 1689716.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    69. Symbiotic pseudorevertants of Rhizobium meliloti ndv mutants. J Bacteriol. 1990 Mar; 172(3):1409-17. Dylan T, Nagpal P, Helinski DR, Ditta GS. PMID: 2307652.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    70. The ndvB locus of Rhizobium meliloti encodes a 319-kDa protein involved in the production of beta-(1----2)-glucan. J Biol Chem. 1990 Feb 15; 265(5):2843-51. Ielpi L, Dylan T, Ditta GS, Helinski DR, Stanfield SW. PMID: 2154461.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    71. Aromatic aminotransferase activity and indoleacetic acid production in Rhizobium meliloti. J Bacteriol. 1989 Oct; 171(10):5458-66. Kittell BL, Helinski DR, Ditta GS. PMID: 2551887.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    72. Negative control of plasmid R6K replication: possible role of intermolecular coupling of replication origins. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7942-6. McEachern MJ, Bott MA, Tooker PA, Helinski DR. PMID: 2682632.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    73. Firefly luciferase as a reporter enzyme for measuring gene expression in vegetative and symbiotic Rhizobium meliloti and other gram-negative bacteria. Gene. 1989 Sep 01; 81(1):55-64. Palomares AJ, DeLuca MA, Helinski DR. PMID: 2680767.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    74. Host-specific effects of the korA-korB operon and oriT region on the maintenance of miniplasmid derivatives of broad host-range plasmid RK2. Plasmid. 1989 Mar; 21(2):99-112. Schmidhauser TJ, Bechhofer DH, Figurski DH, Helinski DR. PMID: 2740456.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    75. The ndvA gene product of Rhizobium meliloti is required for beta-(1----2)glucan production and has homology to the ATP-binding export protein HlyB. J Bacteriol. 1988 Aug; 170(8):3523-30. Stanfield SW, Ielpi L, O'Brochta D, Helinski DR, Ditta GS. PMID: 3042754.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    76. Common regulatory elements control symbiotic and microaerobic induction of nifA in Rhizobium meliloti. Proc Natl Acad Sci U S A. 1988 May; 85(9):3062-5. Virts EL, Stanfield SW, Helinski DR, Ditta GS. PMID: 2834732.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    77. Broad-host-range plasmid cloning vectors for gram-negative bacteria. Biotechnology. 1988; 10:287-332. Schmidhauser TJ, Ditta G, Helinski DR. PMID: 2850044.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    78. The sequence encoding the 43-kilodalton trfA protein is required for efficient replication or maintenance of minimal RK2 replicons in Pseudomonas aeruginosa. Plasmid. 1987 Sep; 18(2):164-9. Durland RH, Helinski DR. PMID: 2829253.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    79. Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol. 1987 Feb; 7(2):725-37. de Wet JR, Wood KV, DeLuca M, Helinski DR, Subramani S. PMID: 3821727.
      View in: PubMed   Mentions: 867     Fields:    Translation:AnimalsCells
    80. DNA and protein interactions in the regulation of plasmid replication. J Cell Sci Suppl. 1987; 7:15-31. Filutowicz M, McEachern MJ, Mukhopadhyay P, Greener A, Yang SL, Helinski DR. PMID: 3332651.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    81. Positive and negative roles of an initiator protein at an origin of replication. Proc Natl Acad Sci U S A. 1986 Dec; 83(24):9645-9. Filutowicz M, McEachern MJ, Helinski DR. PMID: 3540947.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    82. Transient and stable expression of the firefly luciferase gene in plant cells and transgenic plants. Science. 1986 Nov 14; 234(4778):856-9. Ow DW, DE Wet JR, Helinski DR, Howell SH, Wood KV, Deluca M. PMID: 17758108.
      View in: PubMed   Mentions: 140     Fields:    
    83. Replication from one of the three origins of the plasmid R6K requires coupled expression of two plasmid-encoded proteins. J Biol Chem. 1986 Jul 15; 261(20):9534-9. Mukhopadhyay P, Filutowicz M, Helinski DR. PMID: 3013894.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    84. Rhizobium meliloti genes required for nodule development are related to chromosomal virulence genes in Agrobacterium tumefaciens. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4403-7. Dylan T, Ielpi L, Stanfield S, Kashyap L, Douglas C, Yanofsky M, Nester E, Helinski DR, Ditta G. PMID: 16593714.
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    85. Multiple mechanisms generate extrachromosomal circular DNA in Chinese hamster ovary cells. Nucleic Acids Res. 1986 Apr 25; 14(8):3527-38. Stanfield SW, Helinski DR. PMID: 3010241.
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    86. Binding of purified wild-type and mutant pi initiation proteins to a replication origin region of plasmid R6K. J Mol Biol. 1986 Jan 20; 187(2):225-39. Filutowicz M, Uhlenhopp E, Helinski DR. PMID: 3009827.
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    87. Cloning firefly luciferase. Methods Enzymol. 1986; 133:3-14. de Wet JR, Wood KV, Helinski DR, DeLuca M. PMID: 3547031.
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    88. Overlapping transcription of the nifA regulatory gene in Rhizobium meliloti. Gene. 1986; 50(1-3):141-8. Kim CH, Helinski DR, Ditta G. PMID: 3472992.
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    89. Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli. Proc Natl Acad Sci U S A. 1985 Dec; 82(23):7870-3. de Wet JR, Wood KV, Helinski DR, DeLuca M. PMID: 3906652.
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    90. DNA segments of the IncX plasmid R485 determining replication and incompatibility with plasmid R6K. Plasmid. 1985 Nov; 14(3):245-54. Stalker DM, Helinski DR. PMID: 3006104.
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    91. Regions of broad-host-range plasmid RK2 involved in replication and stable maintenance in nine species of gram-negative bacteria. J Bacteriol. 1985 Oct; 164(1):446-55. Schmidhauser TJ, Helinski DR. PMID: 4044529.
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    92. Deletion analysis of Rhizobium meliloti symbiotic promoters. EMBO J. 1985 Oct; 4(10):2419-24. Better M, Ditta G, Helinski DR. PMID: 15929217.
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    93. Comparison of 10 IncP plasmids: homology in the regions involved in plasmid replication. J Bacteriol. 1985 May; 162(2):656-60. Chikami GK, Guiney DG, Schmidhauser TJ, Helinski DR. PMID: 2985542.
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    94. Mutations in direct repeat sequences and in a conserved sequence adjacent to the repeats result in a defective replication origin in plasmid R6K. Proc Natl Acad Sci U S A. 1985 Mar; 82(5):1480-4. McEachern MJ, Filutowicz M, Helinski DR. PMID: 3883361.
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    95. Plasmids related to the broad host range vector, pRK290, useful for gene cloning and for monitoring gene expression. Plasmid. 1985 Mar; 13(2):149-53. Ditta G, Schmidhauser T, Yakobson E, Lu P, Liang XW, Finlay DR, Guiney D, Helinski DR. PMID: 2987994.
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    96. Autorepressor properties of the pi-initiation protein encoded by plasmid R6K. Nucleic Acids Res. 1985 Jan 11; 13(1):103-14. Filutowicz M, Davis G, Greener A, Helinski DR. PMID: 3923429.
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    97. Role of the pi initiation protein and direct nucleotide sequence repeats in the regulation of plasmid R6K replication. Basic Life Sci. 1985; 30:125-40. Filutowicz M, McEachern M, Greener A, Mukhopadhyay P, Uhlenhopp E, Durland R, Helinski D. PMID: 2990404.
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    98. Transcription signals in a region essential for replication of plasmid R6K. Plasmid. 1985 Jan; 13(1):51-8. Shafferman A, Helinski DR. PMID: 3887441.
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    99. Chromogenic immunodetection of human serum albumin and alpha-L-fucosidase clones in a human hepatoma cDNA expression library. DNA. 1984 Dec; 3(6):437-47. de Wet JR, Fukushima H, Dewji NN, Wilcox E, O'Brien JS, Helinski DR. PMID: 6096099.
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    100. Cloning and characterization of small circular DNA from Chinese hamster ovary cells. Mol Cell Biol. 1984 Jan; 4(1):173-80. Stanfield SW, Helinski DR. PMID: 6700583.
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    101. Structural relationships among Rhizobium meliloti symbiotic promoters. Cell. 1983 Dec; 35(2 Pt 1):479-85. Better M, Lewis B, Corbin D, Ditta G, Helinski DR. PMID: 6317191.
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    102. Release of initiation control by a mutational alteration in the R6K pi protein required for plasmid DNA replication. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5500-4. Stalker DM, Filutowicz M, Helinski DR. PMID: 6310578.
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    103. Isolation and characterization of the recA gene of Rhizobium meliloti. J Bacteriol. 1983 Jul; 155(1):311-6. Better M, Helinski DR. PMID: 6305915.
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    104. Replication of derivatives of the broad host range plasmid RK2 in two distantly related bacteria. Plasmid. 1983 May; 9(3):325-30. Schmidhauser TJ, Filutowicz M, Helinski DR. PMID: 6346358.
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    105. Structural properties of the beta origin of replication of plasmid R6K. J Biol Chem. 1983 Apr 10; 258(7):4083-90. Shafferman A, Helinski DR. PMID: 6300075.
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    106. Plasmid R6K DNA replication. II. Direct nucleotide sequence repeats are required for an active gamma-origin. J Mol Biol. 1982 Oct 15; 161(1):45-56. Kolter R, Helinski DR. PMID: 6296394.
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    107. Plasmid R6K DNA replication. I. Complete nucleotide sequence of an autonomously replicating segment. J Mol Biol. 1982 Oct 15; 161(1):33-43. Stalker DM, Kolter R, Helinski DR. PMID: 6759660.
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    108. Plasmid R6K DNA replication. III. Regulatory properties of the pi initiation protein. J Mol Biol. 1982 Oct 15; 161(1):57-76. Shafferman A, Kolter R, Stalker D, Helinski DR. PMID: 6818353.
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    109. Heme biosynthesis in Rhizobium. Identification of a cloned gene coding for delta-aminolevulinic acid synthetase from Rhizobium meliloti. J Biol Chem. 1982 Aug 10; 257(15):8724-30. Leong SA, Ditta GS, Helinski DR. PMID: 7096330.
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    110. Size and base composition of RNA segments in complementary strands of supercoiled plasmid ColE1 DNA. Plasmid. 1982 Mar; 7(2):192-5. Williams PH, Leavitt RW, Helinski DR. PMID: 6177012.
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    111. Synthesis and repair of RNA-containing supercoiled plasmid ColE1 DNA in Escherichia coli. Plasmid. 1982 Mar; 7(2):180-91. Williams PH, Blair DG, Helinski DR. PMID: 6177011.
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    112. Plasmids as vectors for gene cloning: past, present, and future use. Basic Life Sci. 1982; 19:5-24. Helinski D. PMID: 6279087.
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    113. Roundtable discussion of research priorities. Basic Life Sci. 1982; 19:445-68. Valentine RC, Rabson R, Sebek O, Helinski D. PMID: 7066013.
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    114. Clustering of nitrogen fixation (nif) genes in Rhizobium meliloti. J Bacteriol. 1982 Jan; 149(1):221-8. Corbin D, Ditta G, Helinski DR. PMID: 6274844.
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    115. Separation of the minimal replication region of the F plasmid into a replication origin segment and a trans-acting segment. Mol Gen Genet. 1982; 186(3):372-7. Tolun A, Helinski DR. PMID: 6750320.
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    116. Direct repeats of the F plasmid incC region express F incompatibility. Cell. 1981 Jun; 24(3):687-94. Tolun A, Helinski DR. PMID: 7018695.
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    117. Replication and incompatibility properties of segments of the origin region of replication of the broad host range plasmid RK2. Mol Gen Genet. 1981; 181(1):1-7. Thomas CM, Stalker DM, Helinski DR. PMID: 6261080.
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    118. Nucleotide sequence of the region of the origin of replication of the broad host range plasmid RK2. Mol Gen Genet. 1981; 181(1):8-12. Stalker DM, Thomas CM, Helinski DR. PMID: 6261086.
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    119. Activity in vitro of three replication origins of the antibiotic resistance plasmid RSF1040. J Biol Chem. 1980 Dec 10; 255(23):11071-4. Inuzuka N, Inuzuka M, Helinski DR. PMID: 6254956.
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    120. Broad host range DNA cloning system for gram-negative bacteria: construction of a gene bank of Rhizobium meliloti. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7347-51. Ditta G, Stanfield S, Corbin D, Helinski DR. PMID: 7012838.
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    121. Regions of broad-host-range plasmid RK2 which are essential for replication and maintenance. J Bacteriol. 1980 Jan; 141(1):213-22. Thomas CM, Meyer R, Helinski DR. PMID: 6243621.
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    122. Bacterial plasmids: autonomous replication and vehicles for gene cloning. CRC Crit Rev Biochem. 1979 Nov; 7(1):83-101. Helinski DR. PMID: 115636.
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    123. The DNA-protein relaxation complex of the plasmid RK2: location of the site-specific nick in the region of the proposed origin of transfer. Mol Gen Genet. 1979 Oct 03; 176(2):183-9. Guiney DG, Helinski DR. PMID: 393953.
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    124. Suppression of Co1E1 replication properties by the Inc P-1 plasmid RK2 in hybrid plasmids constructed in vitro. J Mol Biol. 1979 Sep 25; 133(3):295-318. Figurski DH, Meyer RJ, Helinski DR. PMID: 395312.
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    125. Bidirectional replication of the mini-ColE1 plasmid pVH51. J Bacteriol. 1979 Apr; 138(1):257-60. Eichenlaub R, Sparks RB, Helinski DR. PMID: 438132.
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    126. Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1648-52. Figurski DH, Helinski DR. PMID: 377280.
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    127. Nucleotide sequence of the region of an origin of replication of the antibiotic resistance plasmid R6K. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1150-4. Stalker DM, Kolter R, Helinski DR. PMID: 375227.
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    128. Association of cellular membrane of E. coli minicells with the origins/terminus region of replication of plasmid ColEl DNA. Nature. 1979 Feb 15; 277(5697):572-4. Sparks RB, Helinski DR. PMID: 368651.
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    129. Essential regions for replication of a stringent and a relaxed plasmid in Escherichia coli. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 1:99-103. Kahn ML, Figurski D, Ito L, Helinski DR. PMID: 383389.
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    130. Regulation of initiation of DNA replication. Annu Rev Genet. 1979; 13:355-91. Kolter R, Helinski DR. PMID: 395895.
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    131. Use of the lambda phage promoter PL to promote gene expression in hybrid plasmid cloning vehicles. Methods Enzymol. 1979; 68:482-92. Bernard HU, Helinski DR. PMID: 232223.
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    132. Construction of plasmid cloning vehicles that promote gene expression from the bacteriophage lambda pL promoter. Gene. 1979 Jan; 5(1):59-76. Bernard HU, Remaut E, Hershfield MV, Das HK, Helinski DR, Yanofsky C, Franklin N. PMID: 372049.
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    133. Plasmid cloning vehicles derived from plasmids ColE1, F, R6K, and RK2. Methods Enzymol. 1979; 68:268-80. Kahn M, Kolter R, Thomas C, Figurski D, Meyer R, Remaut E, Helinski DR. PMID: 232215.
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    134. Plasmid DNA replication: RK2- and R6K-encoded trans-acting factors and their sites of action. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 1:91-7. Kolter R, Inuzuka M, Figurski D, Thomas C, Stalker D, Helinski DR. PMID: 383388.
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    135. Trans-complementation-dependent replication of a low molecular weight origin fragment from plasmid R6K. Cell. 1978 Dec; 15(4):1199-208. Kolter R, Inuzuka M, Helinski DR. PMID: 728998.
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    136. Altered DNA-protein relaxation complex in a replication mutant of plasmid ColE1. Mol Gen Genet. 1978 Nov 16; 167(1):21-8. Collins J, Yanofsky S, Helinski DR. PMID: 368585.
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    137. Requirement of a plasmid-encoded protein for replication in vitro of plasmid R6K. Proc Natl Acad Sci U S A. 1978 Nov; 75(11):5381-5. Inuzuka M, Helinski DR. PMID: 364478.
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    138. Activity of the replication terminus of plasmid R6K in hybrid replicons in Escherichia coli. J Mol Biol. 1978 Sep 25; 124(3):425-41. Kolter R, Helinski DR. PMID: 361971.
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    139. Construction of plasmid R6K derivatives in vitro: characterization of the R6K replication region. Plasmid. 1978 Sep; 1(4):571-80. Kolter R, Helinski DR. PMID: 372982.
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    140. Replication of antibiotic resistance plasmid R6K DNA in vitro. Biochemistry. 1978 Jun 27; 17(13):2567-73. Inuzuka M, Helinski DR. PMID: 354690.
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    141. Construction of a novel plasmid-phage hybrid: use of the hybrid to demonstrate ColE1 DNA replication in vivo in the absence of a ColE1-specified protein. Proc Natl Acad Sci U S A. 1978 May; 75(5):2200-4. Kahn M, Helinski DR. PMID: 276860.
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    142. Unidirectional replication of the P-group plasmid RK2. Biochim Biophys Acta. 1977 Sep 06; 478(1):109-13. Meyer RJ, Helinski DR. PMID: 329885.
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    143. Physical and genetic studies with restriction endonucleases on the broad host-range plasmid RK2. Mol Gen Genet. 1977 Apr 29; 152(3):129-35. Meyer R, Figurski D, Helinski DR. PMID: 327269.
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    144. Purification and characterization of covalently closed replicative intermediates of ColEl DNA from Escherichia coli. Biochemistry. 1977 Apr 19; 16(8):1677-83. Katz L, Williams PH, Sato S, Leavitt RW, Helinski DR. PMID: 322703.
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    145. Gene cloning and containment properties of plasmid Col E1 and its derivatives. Science. 1977 Apr 08; 196(4286):172-4. Armstrong KA, Hershfield V, Helinski DR. PMID: 322277.
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    146. Bidirection replication from a unique origin in a mini-F plasmid. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):1138-41. Eichenlaub R, Figurski D, Helinski DR. PMID: 322144.
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    147. Plasmids as vectors for gene cloning. Basic Life Sci. 1977; 9:19-49. Helinski DR. PMID: 336024.
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    148. Small circular DNA in Drosophila melanogaster. Cell. 1976 Oct; 9(2):333-45. Stanfield S, Helinski DR. PMID: 824055.
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    149. Method for the isolation of the replication region of a bacterial replicon: construction of a mini-F'kn plasmid. J Bacteriol. 1976 Aug; 127(2):982-7. Lovett MA, Helinski DR. PMID: 783124.
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    150. Plasmid DNA replication. Fed Proc. 1976 Jul; 35(9):2026-30. Helinski DR. PMID: 776703.
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    151. Plasmids: introductory remarks. Fed Proc. 1976 Jul; 35(9):2024-5. Helinski DR. PMID: 1064555.
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    152. R factors. Science. 1976 May 21; 192(4241):778. Helinski DR. PMID: 17777179.
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    153. Characterization of a mini-ColC1 plasmid. J Bacteriol. 1976 Apr; 126(1):447-53. Hershfield V, Boyer HW, Chow L, Helinski DR. PMID: 770430.
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    154. Generation in vitro of deletions in the broad host range plasmid RK2 using phage Mu insertions and a restriction endonuclease. Gene. 1976; 1(1):107-19. Figurski D, Meyer R, Miller DS, Helinski DR. PMID: 1052320.
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    155. Molecular vehicle properties of the broad host range plasmid RK2. Science. 1975 Dec 19; 190(4220):1226-8. Meyer R, Figurski D, Helinski DR. PMID: 1060178.
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    156. Relaxation complexes of plasmid DNA and protein. I. Strand-specific association of protein and DNA in the relaxed complexes of plasmids ColE1 and ColE2. J Biol Chem. 1975 Nov 25; 250(22):8785-9. Blair DG, Helinski DR. PMID: 1102543.
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    157. Relaxation complexes of plasmid DNA and protein. II. Characterization of the proteins associated with the unrelaxed and relaxed complexes of plasmid ColE1. J Biol Chem. 1975 Nov 25; 250(22):8790-5. Lovett MA, Helinski DR. PMID: 1102544.
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    158. Relaxation complexes of poasmid DNA and protein. III. Association of protein with the 5' terminus of the broken DNA strand in the relaxed complex of plasmid ColE1. J Biol Chem. 1975 Nov 25; 250(22):8796-803. Guiney DG, Helinski DR. PMID: 1102545.
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    159. Bidirectional replication of plasmid R6K DNA in Escherichia coli; correspondence between origin of replication and position of single-strand break in relaxed complex. Proc Natl Acad Sci U S A. 1975 Aug; 72(8):2905-9. Lovett MA, Sparks RB, Helinski DR. PMID: 1103126.
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    160. Plasmid ColE1 DNA replication in Escherichia coli strains temperature-sensitive for DNA replication. Mol Gen Genet. 1975; 136(4):273-89. Collins J, Williams P, Helinski DR. PMID: 16094996.
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    161. Strand and site specificity of the relaxation event for the relaxation complex of the antibiotic resistance plasmid R6K. Biochemistry. 1974 Dec 31; 13(27):5484-90. Kupersztoch-Portnoy YM, Lovett MA, Helinski DR. PMID: 4616719.
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    162. Breaks induced in supercoiled colicinogenic factor E1 DNA as a result of the decay of incorporated tritium. Biochim Biophys Acta. 1974 Dec 20; 374(3):316-23. Kupersztoch-Portroy YM, Helinski DR. PMID: 4433599.
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    163. Properties of the relaxation complexes of supercoiled deoxyribonucleic acid and protein of the R plasmids R64, R28K, and R6K. J Bacteriol. 1974 Oct; 120(1):545-8. Kupersztoch-Portnoy YM, Miklos GL, Helinski DR. PMID: 4608091.
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    164. Relaxation complexes of plasmids ColE1 and ColE2: unique site of the nick in the open circular DNA of the relaxed complexes. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):3854-7. Lovett MA, Guiney DG, Helinski DR. PMID: 4610563.
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    165. Unidirectional replication of plasmid ColE1 DNA. Nature. 1974 Sep 27; 251(5473):337-40. Lovett MA, Katz L, Helinski DR. PMID: 4610399.
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    166. Plasmid ColEl as a molecular vehicle for cloning and amplification of DNA. Proc Natl Acad Sci U S A. 1974 Sep; 71(9):3455-9. Hershfield V, Boyer HW, Yanofsky C, Lovett MA, Helinski DR. PMID: 4610576.
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    167. Effect of inhibitors of ribonucleic acid and protein synthesis on the cyclic adenosine monophosphate stimulation of plasmid ColE1 replication. J Bacteriol. 1974 Aug; 119(2):450-60. Katz L, Helinski DR. PMID: 4368626.
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    168. A catenated DNA molecule as an intermediate in the replication of the resistance transfer factor R6K in Escherichia coli. Biochem Biophys Res Commun. 1973 Oct 15; 54(4):1451-9. Kupersztoch YM, Helinski DR. PMID: 4585292.
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    169. Bacterial plasmids. Science. 1973 Aug 03; 181(4098):471-2. Helinski DR, Cohen SN, Tomoeda M. PMID: 17793339.
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    170. Replication of colicinogenic factor E1 in Escherichia coli. Properties of newly replicated supercoils. Eur J Biochem. 1973 Aug 01; 37(1):95-9. Sherratt DJ, Helinski DR. PMID: 4580886.
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    171. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli: requirement for deoxyribonucleic acid polymerase I in the replication of the plasmid ColE 1 . J Bacteriol. 1973 Jun; 114(3):1116-24. Kingsbury DT, Helinski DR. PMID: 4576398.
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    172. Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex. J Bacteriol. 1973 May; 114(2):577-91. Katz L, Kingsbury DT, Helinski DR. PMID: 4350343.
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    173. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli. I. Isolation and specificity of host and plasmid mutations. Genetics. 1973 May; 74(1):17-31. Kingsbury DT, Helinski DR. PMID: 4576229.
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    174. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli. II. Properties of host and plasmid mutations. Genetics. 1973 May; 74(1):1-16. Kingsbury DT, Sieckmann DG, Helinski DR. PMID: 4576230.
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    175. Plasmid determined resistance to antibiotics: molecular properties of R factors. Annu Rev Microbiol. 1973; 27:437-70. Helinski DR. PMID: 4584692.
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    176. Replication of plasmid supercoiled DNA. Johns Hopkins Med J Suppl. 1973; 2:15-34. Helinski DR, Blair DG, Sherratt DJ, Lovett M, Kupersztoch Y, Kingsbury DT. PMID: 4607019.
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    177. Isolation of supercoiled colicinogenic factor E 1 DNA sensitive to ribonuclease and alkali. Proc Natl Acad Sci U S A. 1972 Sep; 69(9):2518-22. Blair DG, Sherratt DJ, Clewell DB, Helinski DR. PMID: 4560690.
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    178. Effect of growth conditions on the formation of the relaxation complex of supercoiled ColE1 deoxyribonucleic acid and protein in Escherichia coli. J Bacteriol. 1972 Jun; 110(3):1135-46. Clewell DB, Helinski DR. PMID: 4555406.
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    179. F 1 sex factor of Escherichia coli. Size and purification in the form of a strand-specific relaxation complex of supercoiled deoxyribonucleic acid and protein. Biochemistry. 1971 Dec 21; 10(26):4975-80. Kline BC, Helinski DR. PMID: 4944065.
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    180. Purification and characterization of colicin E1. J Biol Chem. 1971 Oct 25; 246(20):6318-27. Schwartz SA, Helinski DR. PMID: 5001789.
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    181. Endonuclease I of Proteus mirabilis. Purification and demonstration of limited endonuclease activity. J Biol Chem. 1971 Jun 25; 246(12):3851-6. Goebel W, Helinski DR. PMID: 5561464.
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    182. Endonuclease I of Proteus mirabilis. Properties of the noncomplexed and transfer ribonucleic acid-complexed forms of the enzyme. J Biol Chem. 1971 Jun 25; 246(12):3857-62. Goebel W, Helinski DR. PMID: 4327190.
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    183. Circular DNA. Annu Rev Biochem. 1971; 40:899-942. Helinski DR, Clewell DB. PMID: 4942224.
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    184. Strand-specific supercoiled DNA-protein relaxation complexes: comparison of the complexes of bacterial plasmids ColE1 and ColE2. Proc Natl Acad Sci U S A. 1971 Jan; 68(1):210-4. Blair DG, Clewell DB, Sheratt DJ, Helinski DR. PMID: 4924969.
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    185. DNA polymerase as a requirement for the maintenance of the bacterial plasmid colicinogenic factor E1. Biochem Biophys Res Commun. 1970 Dec 24; 41(6):1538-44. Kingsbury DT, Helinski DR. PMID: 4922634.
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    186. Nicking activity of an endonuclease. I. Transfer ribonucleic acid complex of Escherichia coli. Biochemistry. 1970 Nov 24; 9(24):4793-801. Goebel W, Helinski DR. PMID: 4991605.
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    187. Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event. Biochemistry. 1970 Oct 27; 9(22):4428-40. Clewell DB, Helinski DR. PMID: 4919547.
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    188. Evidence for the existence of the colicinogenic factors E2 and E3 as supercoiled circular DNA-protein relaxation complexes. Biochem Biophys Res Commun. 1970 Aug 11; 40(3):608-13. Clewell DB, Helinski DR. PMID: 4923716.
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    189. Replication of a bacterial plasmid and an episome in Escherichia coli. Biochemistry. 1970 Jan 20; 9(2):399-406. Bazaral M, Helinski DR. PMID: 4904868.
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    190. Heterogeneous circular DNA elements in vegetative cultures of Bacillus megaterium. Proc Natl Acad Sci U S A. 1969 Oct; 64(2):592-9. Carlton BC, Helinski DR. PMID: 4982358.
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    191. Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form. Proc Natl Acad Sci U S A. 1969 Apr; 62(4):1159-66. Clewell DB, Helinski DR. PMID: 4894690.
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    192. Generation of higher multiple circular DNA forms in bacteria. Proc Natl Acad Sci U S A. 1968 Dec; 61(4):1406-13. Goebel W, Helinski DR. PMID: 4884687.
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    193. Characterization of multiple circular DNA forms of colicinogenic factor E-1 from Proteus mirabilis. Biochemistry. 1968 Oct; 7(10):3513-20. Bazaral M, Helinski DR. PMID: 4878700.
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    194. Circular DNA forms of colicinogenic factors E1, E2 and E3 from Escherichia coli. J Mol Biol. 1968 Sep 14; 36(2):185-94. Bazaral M, Helinski DR. PMID: 4939624.
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    195. Purification and characterization of colicin E2 and colicin E3. J Biol Chem. 1967 Nov 25; 242(22):5360-8. Herschman HR, Helinski DR. PMID: 4965137.
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    196. Circular DNA forms of a bacterial sex factor. Proc Natl Acad Sci U S A. 1967 Oct; 58(4):1731-8. Hickson FT, Roth TF, Helinski DR. PMID: 5237898.
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    197. Effect of Rec mutations on the activity of colicinogenic factors. J Bacteriol. 1967 Sep; 94(3):700-6. Helinski DR, Herschman HR. PMID: 5340681.
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    198. Comparative study of the events associated with colicin induction. J Bacteriol. 1967 Sep; 94(3):691-9. Herschman HR, Helinski DR. PMID: 5340680.
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    199. Evidence for circular DNA forms of a bacterial plasmid. Proc Natl Acad Sci U S A. 1967 Aug; 58(2):650-7. Roth TF, Helinski DR. PMID: 5233464.
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    200. Comparison of the tryptophan synthetase alpha-subunits of several species of Enterobacteriaceae. J Bacteriol. 1966 May; 91(5):1819-26. Creighton TE, Helinski DR, Somerville RL, Yanofsky C. PMID: 5327908.
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    201. Interaction between colicinogenic factor V and the integrated F factor in an Hfr strain of Escherichia coli. J Bacteriol. 1965 Nov; 90(5):1276-82. Kahn PL, Helinski DR. PMID: 5321482.
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    202. RELATIONSHIP BETWEEN COLICINOGENIC FACTORS E1 AND V AND AN F FACTOR IN ESCHERICHIA COLI. J Bacteriol. 1964 Dec; 88:1573-9. KAHN P, HELINSKI DR. PMID: 14240939.
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    203. ON THE COLINEARITY OF GENE STRUCTURE AND PROTEIN STRUCTURE. Proc Natl Acad Sci U S A. 1964 Feb; 51:266-72. YANOFSKY C, CARLTON BC, GUEST JR, HELINSKI DR, HENNING U. PMID: 14124325.
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    204. A genetic and biochemical analysis of second site reversion. J Biol Chem. 1963 Mar; 238:1043-8. HELINSKI DR, YANOFSKY C. PMID: 13953567.
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    205. Mutational alteration of protein structure. Fed Proc. 1963 Jan-Feb; 22:75-9. YANOFSKY C, HENNING U, HELINSKI D, CARLTON B. PMID: 14002474.
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    206. Peptide pattern studies on the wild-type A protein of the tryptophan synthetase of Escherichia coli. Biochim Biophys Acta. 1962 Sep 10; 63:10-9. HELINSKI DR, YANOFSKY C. PMID: 13953568.
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    207. The A protein of the tryptophan synthetase of Escherichia coli. Purification, crystallization, and composition studies. J Biol Chem. 1962 May; 237:1523-30. HENNING U, HELINSKI DR, CHAO FC, YANOFSKY C. PMID: 13906502.
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    208. Correspondence between genetic data and the position of amino acid alteration in a proein. Proc Natl Acad Sci U S A. 1962 Feb; 48:173-83. HELINSKI DR, YANOFSKY C. PMID: 13906211.
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    209. The effects of mutation on the composition and properties of the A protein of Escherichia coli tryptohan synthetase. Cold Spring Harb Symp Quant Biol. 1961; 26:11-24. YANOFSKY C, HELINSKI DR, MALING BD. PMID: 14008999.
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    210. Studies on the action of bovine serum albumin on aged rat livermitochondria. J Biol Chem. 1960 Dec; 235:3573-9. HELINSKI DR, COOPER C. PMID: 13713081.
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