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Donald Helinski

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0322
La Jolla CA 92093
Phone858-534-3638
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    Collapse Research 
    Collapse Research Activities and Funding
    Structure and Genetic Control of Colicines
    NIH/NIAID R01AI007194Feb 1, 1978 - Apr 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Verheust C, Helinski D. The incC korB region of RK2 repositions a mini-RK2 replicon in Escherichia coli. Plasmid. 2007 Sep; 58(2):195-204. PMID: 17521722.
      View in: PubMed
    2. Yao S, Helinski D, Toukdarian A. Localization of the naturally occurring plasmid ColE1 at the cell pole. J Bacteriol. 2007 Mar; 189(5):1946-53. PMID: 17158664; PMCID: PMC1855736.
    3. Yao S, Toukdarian A, Helinski D. Inhibition of protein and RNA synthesis in Escherichia coli results in declustering of plasmid RK2. Plasmid. 2006 Sep; 56(2):124-32. PMID: 16774785.
      View in: PubMed
    4. Jiang Y, Yao S, Helinski D, Toukdarian A. Functional analysis of two putative chromosomal replication origins from Pseudomonas aeruginosa. Plasmid. 2006 May; 55(3):194-200. PMID: 16376988.
      View in: PubMed
    5. Johnson EP, Yao S, Helinski D. Gyrase inhibitors and thymine starvation disrupt the normal pattern of plasmid RK2 localization in Escherichia coli. J Bacteriol. 2005 May; 187(10):3538-47. PMID: 15866942; PMCID: PMC1112003.
    6. Zhong Z, Helinski D, Toukdarian A. Plasmid host-range: restrictions to F replication in Pseudomonas. Plasmid. 2005 Jul; 54(1):48-56. PMID: 15907538.
      View in: PubMed
    7. Zhong Z, Helinski D, Toukdarian A. A specific region in the N terminus of a replication initiation protein of plasmid RK2 is required for recruitment of Pseudomonas aeruginosa DnaB helicase to the plasmid origin. J Biol Chem. 2003 Nov 14; 278(46):45305-10. PMID: 12952979.
      View in: PubMed
    8. Jiang Y, Pacek M, Helinski D, Konieczny I, Toukdarian A. A multifunctional plasmid-encoded replication initiation protein both recruits and positions an active helicase at the replication origin. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8692-7. PMID: 12835421; PMCID: PMC166374.
    9. Zhong Z, Caspi R, Helinski D, Knauf V, Sykes S, O'Byrne C, Shea TP, Wilkinson JE, DeLoughery C, Toukdarian A. Nucleotide sequence based characterizations of two cryptic plasmids from the marine bacterium Ruegeria isolate PR1b. Plasmid. 2003 May; 49(3):233-52. PMID: 12749836.
      View in: PubMed
    10. Jiang Y, Pogliano J, Helinski D, Konieczny I. ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase. Mol Microbiol. 2002 May; 44(4):971-9. PMID: 12010492.
      View in: PubMed
    11. Zhong Z, Caspi R, Mincer T, Helinski D, Knauf V, Boardman K, Wilkinson JE, Shea T, DeLoughery C, Toukdarian A. A 50-kb plasmid rich in mobile gene sequences isolated from a marine micrococcus. Plasmid. 2002 Jan; 47(1):1-9. PMID: 11798280.
      View in: PubMed
    12. Caspi R, Pacek M, Consiglieri G, Helinski D, Toukdarian A, Konieczny I. A broad host range replicon with different requirements for replication initiation in three bacterial species. EMBO J. 2001 Jun 15; 20(12):3262-71. PMID: 11406602; PMCID: PMC150194.
    13. Pogliano J, Ho TQ, Zhong Z, Helinski D. Multicopy plasmids are clustered and localized in Escherichia coli. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4486-91. PMID: 11274369; PMCID: PMC31861.
    14. Baranska S, Gabig M, Wegrzyn A, Konopa G, Herman-Antosiewicz A, Hernandez P, Schvartzman JB, Helinski D, Wegrzyn G. Regulation of the switch from early to late bacteriophage lambda DNA replication. Microbiology. 2001 Mar; 147(Pt 3):535-47. PMID: 11238961.
      View in: PubMed
    15. Caspi R, Helinski D, Pacek M, Konieczny I. Interactions of DnaA proteins from distantly related bacteria with the replication origin of the broad host range plasmid RK2. J Biol Chem. 2000 Jun 16; 275(24):18454-61. PMID: 10749858.
      View in: PubMed
    16. Johnson EP, Mincer T, Schwab H, Burgin AB, Helinski D. Plasmid RK2 ParB protein: purification and nuclease properties. J Bacteriol. 1999 Oct; 181(19):6010-8. PMID: 10498713; PMCID: PMC103628.
    17. Doran KS, Helinski D, Konieczny I. Host-dependent requirement for specific DnaA boxes for plasmid RK2 replication. Mol Microbiol. 1999 Aug; 33(3):490-8. PMID: 10417640.
      View in: PubMed
    18. Doran KS, Helinski D, Konieczny I. A critical DnaA box directs the cooperative binding of the Escherichia coli DnaA protein to the plasmid RK2 replication origin. J Biol Chem. 1999 Jun 18; 274(25):17918-23. PMID: 10364238.
      View in: PubMed
    19. Toukdarian AE, Helinski D. TrfA dimers play a role in copy-number control of RK2 replication. Gene. 1998 Nov 26; 223(1-2):205-11. PMID: 9858734.
      View in: PubMed
    20. Easter CL, Schwab H, Helinski D. Role of the parCBA operon of the broad-host-range plasmid RK2 in stable plasmid maintenance. J Bacteriol. 1998 Nov; 180(22):6023-30. PMID: 9811663; PMCID: PMC107679.
    21. Szalewska-Palasz A, Lemieszek E, Pankiewicz A, Wegrzyn A, Helinski D, Wegrzyn G. Escherichia coli dnaA gene function and bacteriophage lambda replication. FEMS Microbiol Lett. 1998 Oct 01; 167(1):27-32. PMID: 9785448.
      View in: PubMed
    22. Sobecky PA, Mincer TJ, Chang MC, Toukdarian A, Helinski D. Isolation of broad-host-range replicons from marine sediment bacteria. Appl Environ Microbiol. 1998 Aug; 64(8):2822-30. PMID: 9687436; PMCID: PMC106778.
    23. Doran KS, Konieczny I, Helinski D. Replication origin of the broad host range plasmid RK2. Positioning of various motifs is critical for initiation of replication. J Biol Chem. 1998 Apr 03; 273(14):8447-53. PMID: 9525957.
      View in: PubMed
    24. Konieczny I, Helinski D. Helicase delivery and activation by DnaA and TrfA proteins during the initiation of replication of the broad host range plasmid RK2. J Biol Chem. 1997 Dec 26; 272(52):33312-8. PMID: 9407123.
      View in: PubMed
    25. Konieczny I, Helinski D. The replication initiation protein of the broad-host-range plasmid RK2 is activated by the ClpX chaperone. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14378-82. PMID: 9405620; PMCID: PMC24985.
    26. Easter CL, Sobecky PA, Helinski D. Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2. J Bacteriol. 1997 Oct; 179(20):6472-9. PMID: 9335298; PMCID: PMC179565.
    27. Konieczny I, Doran KS, Helinski D, Blasina A. Role of TrfA and DnaA proteins in origin opening during initiation of DNA replication of the broad host range plasmid RK2. J Biol Chem. 1997 Aug 08; 272(32):20173-8. PMID: 9242693.
      View in: PubMed
    28. Sobecky PA, Mincer TJ, Chang MC, Helinski D. Plasmids isolated from marine sediment microbial communities contain replication and incompatibility regions unrelated to those of known plasmid groups. Appl Environ Microbiol. 1997 Mar; 63(3):888-95. PMID: 9055407; PMCID: PMC168381.
    29. Blasina A, Kittell BL, Toukdarian AE, Helinski D. Copy-up mutants of the plasmid RK2 replication initiation protein are defective in coupling RK2 replication origins. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3559-64. PMID: 8622975; PMCID: PMC39649.
    30. Sobecky PA, Easter CL, Bear PD, Helinski D. Characterization of the stable maintenance properties of the par region of broad-host-range plasmid RK2. J Bacteriol. 1996 Apr; 178(7):2086-93. PMID: 8606188; PMCID: PMC177909.
    31. Toukdarian AE, Helinski D, Perri S. The plasmid RK2 initiation protein binds to the origin of replication as a monomer. J Biol Chem. 1996 Mar 22; 271(12):7072-8. PMID: 8636140.
      View in: PubMed
    32. Johnson EP, Strom AR, Helinski D. Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein. J Bacteriol. 1996 Mar; 178(5):1420-9. PMID: 8631720; PMCID: PMC177817.
    33. Sia EA, Roberts RC, Easter C, Helinski D, Figurski DH. Different relative importances of the par operons and the effect of conjugal transfer on the maintenance of intact promiscuous plasmid RK2. J Bacteriol. 1995 May; 177(10):2789-97. PMID: 7751288; PMCID: PMC176950.
    34. Wegrzyn G, Wegrzyn A, Konieczny I, Bielawski K, Konopa G, Obuchowski M, Helinski D, Taylor K. Involvement of the host initiator function dnaA in the replication of coliphage lambda. Genetics. 1995 Apr; 139(4):1469-81. PMID: 7789753; PMCID: PMC1206477.
    35. Monson EK, Ditta GS, Helinski D. The oxygen sensor protein, FixL, of Rhizobium meliloti. Role of histidine residues in heme binding, phosphorylation, and signal transduction. J Biol Chem. 1995 Mar 10; 270(10):5243-50. PMID: 7890634.
      View in: PubMed
    36. Pansegrau W, Lanka E, Barth PT, Figurski DH, Guiney DG, Haas D, Helinski D, Schwab H, Stanisich VA, Thomas CM. Complete nucleotide sequence of Birmingham IncP alpha plasmids. Compilation and comparative analysis. J Mol Biol. 1994 Jun 24; 239(5):623-63. PMID: 8014987.
      View in: PubMed
    37. Roberts RC, Ström AR, Helinski D. The parDE operon of the broad-host-range plasmid RK2 specifies growth inhibition associated with plasmid loss. J Mol Biol. 1994 Mar 18; 237(1):35-51. PMID: 8133518.
      View in: PubMed
    38. Cereghino JL, Helinski D, Toukdarian AE. Isolation and characterization of DNA-binding mutants of a plasmid replication initiation protein utilizing an in vivo binding assay. Plasmid. 1994 Jan; 31(1):89-99. PMID: 8171128.
      View in: PubMed
    39. Roberts RC, Spangler C, Helinski D. Characteristics and significance of DNA binding activity of plasmid stabilization protein ParD from the broad host-range plasmid RK2. J Biol Chem. 1993 Dec 25; 268(36):27109-17. PMID: 8262949.
      View in: PubMed
    40. Weinstein M, Lois AF, Ditta GS, Helinski D. Mutants of the two-component regulatory protein FixJ of Rhizobium meliloti that have increased activity at the nifA promoter. Gene. 1993 Dec 08; 134(2):145-52. PMID: 8262372.
      View in: PubMed
    41. Cereghino JL, Helinski D. Essentiality of the three carboxyl-terminal amino acids of the plasmid RK2 replication initiation protein TrfA for DNA binding and replication activity in gram-negative bacteria. J Biol Chem. 1993 Nov 25; 268(33):24926-32. PMID: 8227054.
      View in: PubMed
    42. Fang FC, Durland RH, Helinski D. Mutations in the gene encoding the replication-initiation protein of plasmid RK2 produce elevated copy numbers of RK2 derivatives in Escherichia coli and distantly related bacteria. Gene. 1993 Oct 29; 133(1):1-8. PMID: 8224880.
      View in: PubMed
    43. Agron PG, Ditta GS, Helinski D. Oxygen regulation of nifA transcription in vitro. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3506-10. PMID: 8475099; PMCID: PMC46329.
    44. Lois AF, Weinstein M, Ditta GS, Helinski D. Autophosphorylation and phosphatase activities of the oxygen-sensing protein FixL of Rhizobium meliloti are coordinately regulated by oxygen. J Biol Chem. 1993 Feb 25; 268(6):4370-5. PMID: 8382700.
      View in: PubMed
    45. Perri S, Helinski D. DNA sequence requirements for interaction of the RK2 replication initiation protein with plasmid origin repeats. J Biol Chem. 1993 Feb 15; 268(5):3662-9. PMID: 8429042.
      View in: PubMed
    46. Lois AF, Ditta GS, Helinski D. The oxygen sensor FixL of Rhizobium meliloti is a membrane protein containing four possible transmembrane segments. J Bacteriol. 1993 Feb; 175(4):1103-9. PMID: 8432704; PMCID: PMC193026.
    47. Roberts RC, Helinski D. Definition of a minimal plasmid stabilization system from the broad-host-range plasmid RK2. J Bacteriol. 1992 Dec; 174(24):8119-32. PMID: 1459960; PMCID: PMC207551.
    48. Weinstein M, Roberts RC, Helinski D. A region of the broad-host-range plasmid RK2 causes stable in planta inheritance of plasmids in Rhizobium meliloti cells isolated from alfalfa root nodules. J Bacteriol. 1992 Nov; 174(22):7486-9. PMID: 1429472; PMCID: PMC207450.
    49. Weinstein M, Lois AF, Monson EK, Ditta GS, Helinski D. Isolation of phosphorylation-deficient mutants of the Rhizobium meliloti two-component regulatory protein, FixJ. Mol Microbiol. 1992 Aug; 6(15):2041-9. PMID: 1406247.
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    50. Davis TL, Helinski D, Roberts RC. Transcription and autoregulation of the stabilizing functions of broad-host-range plasmid RK2 in Escherichia coli, Agrobacterium tumefaciens and Pseudomonas aeruginosa. Mol Microbiol. 1992 Jul; 6(14):1981-94. PMID: 1508045.
      View in: PubMed
    51. Lin J, Helinski D. Analysis of mutations in trfA, the replication initiation gene of the broad-host-range plasmid RK2. J Bacteriol. 1992 Jun; 174(12):4110-9. PMID: 1597426; PMCID: PMC206123.
    52. Agron PG, Ditta GS, Helinski D. Mutational analysis of the Rhizobium meliloti nifA promoter. J Bacteriol. 1992 Jun; 174(12):4120-9. PMID: 1597427; PMCID: PMC206124.
    53. Monson EK, Weinstein M, Ditta GS, Helinski D. The FixL protein of Rhizobium meliloti can be separated into a heme-binding oxygen-sensing domain and a functional C-terminal kinase domain. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4280-4. PMID: 1584762; PMCID: PMC49065.
    54. Greener A, Lehman SM, Helinski D. Promoters of the broad host range plasmid RK2: analysis of transcription (initiation) in five species of gram-negative bacteria. Genetics. 1992 Jan; 130(1):27-36. PMID: 1732166; PMCID: PMC1204802.
    55. Fang FC, Helinski D. Broad-host-range properties of plasmid RK2: importance of overlapping genes encoding the plasmid replication initiation protein TrfA. J Bacteriol. 1991 Sep; 173(18):5861-8. PMID: 1885553; PMCID: PMC208320.
    56. Perri S, Helinski D, Toukdarian A. Interactions of plasmid-encoded replication initiation proteins with the origin of DNA replication in the broad host range plasmid RK2. J Biol Chem. 1991 Jul 05; 266(19):12536-43. PMID: 2061326.
      View in: PubMed
    57. Gilles-Gonzalez MA, Ditta GS, Helinski D. A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti. Nature. 1991 Mar 14; 350(6314):170-2. PMID: 1848683.
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    58. Valla S, Haugan K, Durland R, Helinski D. Isolation and properties of temperature-sensitive mutants of the trfA gene of the broad host range plasmid RK2. Plasmid. 1991 Mar; 25(2):131-6. PMID: 1857753.
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    59. Kittell BL, Helinski D. Iteron inhibition of plasmid RK2 replication in vitro: evidence for intermolecular coupling of replication origins as a mechanism for RK2 replication control. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1389-93. PMID: 1996339; PMCID: PMC51023.
    60. Roberts RC, Burioni R, Helinski D. Genetic characterization of the stabilizing functions of a region of broad-host-range plasmid RK2. J Bacteriol. 1990 Nov; 172(11):6204-16. PMID: 2121707; PMCID: PMC526801.
    61. Greener A, Filutowicz MS, McEachern MJ, Helinski D. N-terminal truncated forms of the bifunctional pi initiation protein express negative activity on plasmid R6K replication. Mol Gen Genet. 1990 Oct; 224(1):24-32. PMID: 2277631.
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    62. Durland RH, Helinski D. Replication of the broad-host-range plasmid RK2: direct measurement of intracellular concentrations of the essential TrfA replication proteins and their effect on plasmid copy number. J Bacteriol. 1990 Jul; 172(7):3849-58. PMID: 2193920; PMCID: PMC213366.
    63. Durland RH, Toukdarian A, Fang F, Helinski D. Mutations in the trfA replication gene of the broad-host-range plasmid RK2 result in elevated plasmid copy numbers. J Bacteriol. 1990 Jul; 172(7):3859-67. PMID: 2193921; PMCID: PMC213367.
    64. Dylan T, Helinski D, Ditta GS. Hypoosmotic adaptation in Rhizobium meliloti requires beta-(1----2)-glucan. J Bacteriol. 1990 Mar; 172(3):1400-8. PMID: 1689716; PMCID: PMC208612.
    65. Dylan T, Nagpal P, Helinski D, Ditta GS. Symbiotic pseudorevertants of Rhizobium meliloti ndv mutants. J Bacteriol. 1990 Mar; 172(3):1409-17. PMID: 2307652; PMCID: PMC208613.
    66. Ielpi L, Dylan T, Ditta GS, Helinski D, Stanfield SW. The ndvB locus of Rhizobium meliloti encodes a 319-kDa protein involved in the production of beta-(1----2)-glucan. J Biol Chem. 1990 Feb 15; 265(5):2843-51. PMID: 2154461.
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    67. Kittell BL, Helinski D, Ditta GS. Aromatic aminotransferase activity and indoleacetic acid production in Rhizobium meliloti. J Bacteriol. 1989 Oct; 171(10):5458-66. PMID: 2551887; PMCID: PMC210384.
    68. McEachern MJ, Bott MA, Tooker PA, Helinski D. Negative control of plasmid R6K replication: possible role of intermolecular coupling of replication origins. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7942-6. PMID: 2682632; PMCID: PMC298188.
    69. Palomares AJ, DeLuca MA, Helinski D. Firefly luciferase as a reporter enzyme for measuring gene expression in vegetative and symbiotic Rhizobium meliloti and other gram-negative bacteria. Gene. 1989 Sep 01; 81(1):55-64. PMID: 2680767.
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    70. Schmidhauser TJ, Bechhofer DH, Figurski DH, Helinski D. Host-specific effects of the korA-korB operon and oriT region on the maintenance of miniplasmid derivatives of broad host-range plasmid RK2. Plasmid. 1989 Mar; 21(2):99-112. PMID: 2740456.
      View in: PubMed
    71. Stanfield SW, Ielpi L, O'Brochta D, Helinski D, Ditta GS. The ndvA gene product of Rhizobium meliloti is required for beta-(1----2)glucan production and has homology to the ATP-binding export protein HlyB. J Bacteriol. 1988 Aug; 170(8):3523-30. PMID: 3042754; PMCID: PMC211323.
    72. Virts EL, Stanfield SW, Helinski D, Ditta GS. Common regulatory elements control symbiotic and microaerobic induction of nifA in Rhizobium meliloti. Proc Natl Acad Sci U S A. 1988 May; 85(9):3062-5. PMID: 2834732; PMCID: PMC280143.
    73. Durland RH, Helinski D. The sequence encoding the 43-kilodalton trfA protein is required for efficient replication or maintenance of minimal RK2 replicons in Pseudomonas aeruginosa. Plasmid. 1987 Sep; 18(2):164-9. PMID: 2829253.
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    74. Filutowicz M, McEachern MJ, Mukhopadhyay P, Greener A, Yang SL, Helinski D. DNA and protein interactions in the regulation of plasmid replication. J Cell Sci Suppl. 1987; 7:15-31. PMID: 3332651.
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    75. Filutowicz M, McEachern MJ, Helinski D. Positive and negative roles of an initiator protein at an origin of replication. Proc Natl Acad Sci U S A. 1986 Dec; 83(24):9645-9. PMID: 3540947; PMCID: PMC387197.
    76. Mukhopadhyay P, Filutowicz M, Helinski D. Replication from one of the three origins of the plasmid R6K requires coupled expression of two plasmid-encoded proteins. J Biol Chem. 1986 Jul 15; 261(20):9534-9. PMID: 3013894.
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    77. Dylan T, Ielpi L, Stanfield S, Kashyap L, Douglas C, Yanofsky M, Nester E, Helinski D, Ditta G. Rhizobium meliloti genes required for nodule development are related to chromosomal virulence genes in Agrobacterium tumefaciens. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4403-7. PMID: 16593714.
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    78. Filutowicz M, Uhlenhopp E, Helinski D. Binding of purified wild-type and mutant pi initiation proteins to a replication origin region of plasmid R6K. J Mol Biol. 1986 Jan 20; 187(2):225-39. PMID: 3009827.
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    79. Stalker DM, Helinski D. DNA segments of the IncX plasmid R485 determining replication and incompatibility with plasmid R6K. Plasmid. 1985 Nov; 14(3):245-54. PMID: 3006104.
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    80. Schmidhauser TJ, Helinski D. Regions of broad-host-range plasmid RK2 involved in replication and stable maintenance in nine species of gram-negative bacteria. J Bacteriol. 1985 Oct; 164(1):446-55. PMID: 4044529; PMCID: PMC214264.
    81. Better M, Ditta G, Helinski D. Deletion analysis of Rhizobium meliloti symbiotic promoters. EMBO J. 1985 Oct; 4(10):2419-24. PMID: 15929217; PMCID: PMC554523.
    82. Chikami GK, Guiney DG, Schmidhauser TJ, Helinski D. Comparison of 10 IncP plasmids: homology in the regions involved in plasmid replication. J Bacteriol. 1985 May; 162(2):656-60. PMID: 2985542; PMCID: PMC218900.
    83. McEachern MJ, Filutowicz M, Helinski D. Mutations in direct repeat sequences and in a conserved sequence adjacent to the repeats result in a defective replication origin in plasmid R6K. Proc Natl Acad Sci U S A. 1985 Mar; 82(5):1480-4. PMID: 3883361; PMCID: PMC397286.
    84. Ditta G, Schmidhauser T, Yakobson E, Lu P, Liang XW, Finlay DR, Guiney D, Helinski D. Plasmids related to the broad host range vector, pRK290, useful for gene cloning and for monitoring gene expression. Plasmid. 1985 Mar; 13(2):149-53. PMID: 2987994.
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    85. Filutowicz M, Davis G, Greener A, Helinski D. Autorepressor properties of the pi-initiation protein encoded by plasmid R6K. Nucleic Acids Res. 1985 Jan 11; 13(1):103-14. PMID: 3923429; PMCID: PMC340977.
    86. Shafferman A, Helinski D. Transcription signals in a region essential for replication of plasmid R6K. Plasmid. 1985 Jan; 13(1):51-8. PMID: 3887441.
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    87. Stalker DM, Filutowicz M, Helinski D. Release of initiation control by a mutational alteration in the R6K pi protein required for plasmid DNA replication. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5500-4. PMID: 6310578; PMCID: PMC384285.
    88. Better M, Helinski D. Isolation and characterization of the recA gene of Rhizobium meliloti. J Bacteriol. 1983 Jul; 155(1):311-6. PMID: 6305915; PMCID: PMC217682.
    89. Schmidhauser TJ, Filutowicz M, Helinski D. Replication of derivatives of the broad host range plasmid RK2 in two distantly related bacteria. Plasmid. 1983 May; 9(3):325-30. PMID: 6346358.
      View in: PubMed
    90. Shafferman A, Helinski D. Structural properties of the beta origin of replication of plasmid R6K. J Biol Chem. 1983 Apr 10; 258(7):4083-90. PMID: 6300075.
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    91. Stalker DM, Kolter R, Helinski D. Plasmid R6K DNA replication. I. Complete nucleotide sequence of an autonomously replicating segment. J Mol Biol. 1982 Oct 15; 161(1):33-43. PMID: 6759660.
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    92. Shafferman A, Kolter R, Stalker D, Helinski D. Plasmid R6K DNA replication. III. Regulatory properties of the pi initiation protein. J Mol Biol. 1982 Oct 15; 161(1):57-76. PMID: 6818353.
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    93. Kolter R, Helinski D. Plasmid R6K DNA replication. II. Direct nucleotide sequence repeats are required for an active gamma-origin. J Mol Biol. 1982 Oct 15; 161(1):45-56. PMID: 6296394.
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    94. Williams PH, Blair DG, Helinski D. Synthesis and repair of RNA-containing supercoiled plasmid ColE1 DNA in Escherichia coli. Plasmid. 1982 Mar; 7(2):180-91. PMID: 6177011.
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    95. Williams PH, Leavitt RW, Helinski D. Size and base composition of RNA segments in complementary strands of supercoiled plasmid ColE1 DNA. Plasmid. 1982 Mar; 7(2):192-5. PMID: 6177012.
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    96. Tolun A, Helinski D. Separation of the minimal replication region of the F plasmid into a replication origin segment and a trans-acting segment. Mol Gen Genet. 1982; 186(3):372-7. PMID: 6750320.
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    97. Tolun A, Helinski D. Direct repeats of the F plasmid incC region express F incompatibility. Cell. 1981 Jun; 24(3):687-94. PMID: 7018695.
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    98. Thomas CM, Stalker DM, Helinski D. Replication and incompatibility properties of segments of the origin region of replication of the broad host range plasmid RK2. Mol Gen Genet. 1981; 181(1):1-7. PMID: 6261080.
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    99. Stalker DM, Thomas CM, Helinski D. Nucleotide sequence of the region of the origin of replication of the broad host range plasmid RK2. Mol Gen Genet. 1981; 181(1):8-12. PMID: 6261086.
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    100. Inuzuka N, Inuzuka M, Helinski D. Activity in vitro of three replication origins of the antibiotic resistance plasmid RSF1040. J Biol Chem. 1980 Dec 10; 255(23):11071-4. PMID: 6254956.
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    101. Thomas CM, Meyer R, Helinski D. Regions of broad-host-range plasmid RK2 which are essential for replication and maintenance. J Bacteriol. 1980 Jan; 141(1):213-22. PMID: 6243621; PMCID: PMC293566.
    102. Helinski D. Bacterial plasmids: autonomous replication and vehicles for gene cloning. CRC Crit Rev Biochem. 1979 Nov; 7(1):83-101. PMID: 115636.
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    103. Guiney DG, Helinski D. The DNA-protein relaxation complex of the plasmid RK2: location of the site-specific nick in the region of the proposed origin of transfer. Mol Gen Genet. 1979 Oct 03; 176(2):183-9. PMID: 393953.
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    104. Figurski DH, Meyer RJ, Helinski D. Suppression of Co1E1 replication properties by the Inc P-1 plasmid RK2 in hybrid plasmids constructed in vitro. J Mol Biol. 1979 Sep 25; 133(3):295-318. PMID: 395312.
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    105. Figurski DH, Helinski D. Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1648-52. PMID: 377280; PMCID: PMC383447.
    106. Eichenlaub R, Sparks RB, Helinski D. Bidirectional replication of the mini-ColE1 plasmid pVH51. J Bacteriol. 1979 Apr; 138(1):257-60. PMID: 438132; PMCID: PMC218267.
    107. Stalker DM, Kolter R, Helinski D. Nucleotide sequence of the region of an origin of replication of the antibiotic resistance plasmid R6K. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1150-4. PMID: 375227; PMCID: PMC383207.
    108. Sparks RB, Helinski D. Association of cellular membrane of E. coli minicells with the origins/terminus region of replication of plasmid ColEl DNA. Nature. 1979 Feb 15; 277(5697):572-4. PMID: 368651.
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    109. Kahn ML, Figurski D, Ito L, Helinski D. Essential regions for replication of a stringent and a relaxed plasmid in Escherichia coli. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 1:99-103. PMID: 383389.
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    110. Kahn M, Kolter R, Thomas C, Figurski D, Meyer R, Remaut E, Helinski D. Plasmid cloning vehicles derived from plasmids ColE1, F, R6K, and RK2. Methods Enzymol. 1979; 68:268-80. PMID: 232215.
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    111. Kolter R, Inuzuka M, Figurski D, Thomas C, Stalker D, Helinski D. Plasmid DNA replication: RK2- and R6K-encoded trans-acting factors and their sites of action. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 1:91-7. PMID: 383388.
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    112. Kolter R, Inuzuka M, Helinski D. Trans-complementation-dependent replication of a low molecular weight origin fragment from plasmid R6K. Cell. 1978 Dec; 15(4):1199-208. PMID: 728998.
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    113. Collins J, Yanofsky S, Helinski D. Altered DNA-protein relaxation complex in a replication mutant of plasmid ColE1. Mol Gen Genet. 1978 Nov 16; 167(1):21-8. PMID: 368585.
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    114. Inuzuka M, Helinski D. Requirement of a plasmid-encoded protein for replication in vitro of plasmid R6K. Proc Natl Acad Sci U S A. 1978 Nov; 75(11):5381-5. PMID: 364478; PMCID: PMC392967.
    115. Kolter R, Helinski D. Activity of the replication terminus of plasmid R6K in hybrid replicons in Escherichia coli. J Mol Biol. 1978 Sep 25; 124(3):425-41. PMID: 361971.
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    116. Kolter R, Helinski D. Construction of plasmid R6K derivatives in vitro: characterization of the R6K replication region. Plasmid. 1978 Sep; 1(4):571-80. PMID: 372982.
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    117. Kahn M, Helinski D. Construction of a novel plasmid-phage hybrid: use of the hybrid to demonstrate ColE1 DNA replication in vivo in the absence of a ColE1-specified protein. Proc Natl Acad Sci U S A. 1978 May; 75(5):2200-4. PMID: 276860; PMCID: PMC392519.
    118. Meyer RJ, Helinski D. Unidirectional replication of the P-group plasmid RK2. Biochim Biophys Acta. 1977 Sep 06; 478(1):109-13. PMID: 329885.
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    119. Meyer R, Figurski D, Helinski D. Physical and genetic studies with restriction endonucleases on the broad host-range plasmid RK2. Mol Gen Genet. 1977 Apr 29; 152(3):129-35. PMID: 327269.
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    120. Eichenlaub R, Figurski D, Helinski D. Bidirection replication from a unique origin in a mini-F plasmid. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):1138-41. PMID: 322144; PMCID: PMC430623.
    121. Helinski D. Plasmids as vectors for gene cloning. Basic Life Sci. 1977; 9:19-49. PMID: 336024.
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    122. Lovett MA, Helinski D. Method for the isolation of the replication region of a bacterial replicon: construction of a mini-F'kn plasmid. J Bacteriol. 1976 Aug; 127(2):982-7. PMID: 783124; PMCID: PMC233008.
    123. Helinski D. Plasmid DNA replication. Fed Proc. 1976 Jul; 35(9):2026-30. PMID: 776703.
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    124. Hershfield V, Boyer HW, Chow L, Helinski D. Characterization of a mini-ColC1 plasmid. J Bacteriol. 1976 Apr; 126(1):447-53. PMID: 770430; PMCID: PMC233301.
    125. Figurski D, Meyer R, Miller DS, Helinski D. Generation in vitro of deletions in the broad host range plasmid RK2 using phage Mu insertions and a restriction endonuclease. Gene. 1976; 1(1):107-19. PMID: 1052320.
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    126. Meyer R, Figurski D, Helinski D. Molecular vehicle properties of the broad host range plasmid RK2. Science. 1975 Dec 19; 190(4220):1226-8. PMID: 1060178.
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    127. Blair DG, Helinski D. Relaxation complexes of plasmid DNA and protein. I. Strand-specific association of protein and DNA in the relaxed complexes of plasmids ColE1 and ColE2. J Biol Chem. 1975 Nov 25; 250(22):8785-9. PMID: 1102543.
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    128. Guiney DG, Helinski D. Relaxation complexes of poasmid DNA and protein. III. Association of protein with the 5' terminus of the broken DNA strand in the relaxed complex of plasmid ColE1. J Biol Chem. 1975 Nov 25; 250(22):8796-803. PMID: 1102545.
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    129. Lovett MA, Helinski D. Relaxation complexes of plasmid DNA and protein. II. Characterization of the proteins associated with the unrelaxed and relaxed complexes of plasmid ColE1. J Biol Chem. 1975 Nov 25; 250(22):8790-5. PMID: 1102544.
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    130. Lovett MA, Sparks RB, Helinski D. Bidirectional replication of plasmid R6K DNA in Escherichia coli; correspondence between origin of replication and position of single-strand break in relaxed complex. Proc Natl Acad Sci U S A. 1975 Aug; 72(8):2905-9. PMID: 1103126; PMCID: PMC432887.
    131. Collins J, Williams P, Helinski D. Plasmid ColE1 DNA replication in Escherichia coli strains temperature-sensitive for DNA replication. Mol Gen Genet. 1975; 136(4):273-89. PMID: 16094996.
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    132. Kupersztoch-Portnoy YM, Miklos GL, Helinski D. Properties of the relaxation complexes of supercoiled deoxyribonucleic acid and protein of the R plasmids R64, R28K, and R6K. J Bacteriol. 1974 Oct; 120(1):545-8. PMID: 4608091; PMCID: PMC245799.
    133. Lovett MA, Katz L, Helinski D. Unidirectional replication of plasmid ColE1 DNA. Nature. 1974 Sep 27; 251(5473):337-40. PMID: 4610399.
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    134. Katz L, Helinski D. Effect of inhibitors of ribonucleic acid and protein synthesis on the cyclic adenosine monophosphate stimulation of plasmid ColE1 replication. J Bacteriol. 1974 Aug; 119(2):450-60. PMID: 4368626; PMCID: PMC245627.
    135. Sherratt DJ, Helinski D. Replication of colicinogenic factor E1 in Escherichia coli. Properties of newly replicated supercoils. Eur J Biochem. 1973 Aug 01; 37(1):95-9. PMID: 4580886.
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    136. Kingsbury DT, Helinski D. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli: requirement for deoxyribonucleic acid polymerase I in the replication of the plasmid ColE 1 . J Bacteriol. 1973 Jun; 114(3):1116-24. PMID: 4576398; PMCID: PMC285372.
    137. Katz L, Kingsbury DT, Helinski D. Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex. J Bacteriol. 1973 May; 114(2):577-91. PMID: 4350343; PMCID: PMC251812.
    138. Helinski D, Blair DG, Sherratt DJ, Lovett M, Kupersztoch Y, Kingsbury DT. Replication of plasmid supercoiled DNA. Johns Hopkins Med J Suppl. 1973; 2:15-34. PMID: 4607019.
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    139. Clewell DB, Helinski D. Effect of growth conditions on the formation of the relaxation complex of supercoiled ColE1 deoxyribonucleic acid and protein in Escherichia coli. J Bacteriol. 1972 Jun; 110(3):1135-46. PMID: 4555406; PMCID: PMC247537.
    140. Bazaral M, Helinski D. Replication of a bacterial plasmid and an episome in Escherichia coli. Biochemistry. 1970 Jan 20; 9(2):399-406. PMID: 4904868.
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    141. KAHN P, HELINSKI DR. RELATIONSHIP BETWEEN COLICINOGENIC FACTORS E1 AND V AND AN F FACTOR IN ESCHERICHIA COLI. J Bacteriol. 1964 Dec; 88:1573-9. PMID: 14240939; PMCID: PMC277454.
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