Elina Zuniga

Title(s)Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanisms Underlying Dendritic Cell Adaptations During Chronic Infection
    NIH R01AI145314Dec 11, 2019 - Nov 30, 2024
    Role: Principal Investigator
    Positive Immune-regulators During Chronic Viral Infections
    NIH R01AI113923Feb 1, 2015 - Jun 30, 2025
    Role: Principal Investigator
    Characterizing Inflammation And Downstream Effects During Chronic Viral Infection
    NIH R56AI097662Aug 27, 2012 - Jul 31, 2014
    Role: Principal Investigator
    GP130 Signaling During Chronic Virus Infection
    NIH R21AI101561Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Arenavirus Subversion of Dendritic Cells
    NIH R21AI102247Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Inhibitory Pathways Underlying Viral Persistence In Vivo
    NIH R01AI081923Jul 1, 2009 - Jan 31, 2021
    Role: Principal Investigator
    Virus interference with Toll like Receptor Response on Dendritic Cells
    NIH R21AI072752Jun 5, 2009 - May 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection. bioRxiv. 2024 Mar 03. Greene TT, Jo Y, Macal M, Fang Z, Khatri FS, Codrington AL, Kazane KR, Chiale C, Akbulut E, Swaminathan S, Fujita Y, Fitzgerald-Bocarsly P, Cordes T, Metallo C, Scott DA, Zuniga EI. PMID: 38464328; PMCID: PMC10925345.
      View in: PubMed   Mentions:
    2. The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine. Life Sci Alliance. 2023 11; 6(11). Hernandez JE, Llorente C, Ma S, Miyamoto KT, Sinha S, Steele S, Xiao Z, Lai CJ, Zuniga EI, Ghosh P, Schnabl B, Huang WJM. PMID: 37666668; PMCID: PMC10477432.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection. Front Immunol. 2023; 14:1221562. Harker JA, Greene TT, Barnett BE, Bao P, Dolgoter A, Zuniga EI. PMID: 37583704; PMCID: PMC10424726.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection. PLoS Biol. 2023 01; 21(1):e3001983. Quezada LK, Jin W, Liu YC, Kim ES, He Z, Indralingam CS, Tysl T, Labarta-Bajo L, Wehrens EJ, Jo Y, Kazane KR, Hattori C, Zuniga EI, Yeo GW, Chang JT. PMID: 36716323; PMCID: PMC9886247.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infection. Immunol Rev. 2022 08; 309(1):12-24. Chiale C, Greene TT, Zuniga EI. PMID: 35775361; PMCID: PMC9350402.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    6. Finding your niche: immune evasion in quiescent tumor reservoirs. Trends Immunol. 2022 07; 43(7):500-502. Greene TT, Kazane KR, Zuniga EI. PMID: 35672237; PMCID: PMC9674368.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response. Front Immunol. 2022; 13:828734. Serrán MG, Vernengo FF, Almada L, Beccaria CG, Gazzoni Y, Canete PF, Roco JA, Boari JT, Ramello MC, Wehrens E, Cai Y, Zuniga EI, Montes CL, Cockburn IA, Rodriguez EVA, Vinuesa CG, Gruppi A. PMID: 35651611; PMCID: PMC9149371.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection. Sci Rep. 2022 03 30; 12(1):5382. Kim SY, Gupta P, Johns SC, Zuniga EI, Teijaro JR, Fuster MM. PMID: 35354833; PMCID: PMC8968721.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Type I Interferon Induction and Exhaustion during Viral Infection: Plasmacytoid Dendritic Cells and Emerging COVID-19 Findings. Viruses. 2021 09 15; 13(9). Greene TT, Zuniga EI. PMID: 34578420; PMCID: PMC8472174.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    10. Infection and cancer suppress pDC derived IFN-I. Curr Opin Immunol. 2020 10; 66:114-122. Greene TT, Jo YR, Zuniga EI. PMID: 32947131; PMCID: PMC8526282.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    11. An Unusual MHC Molecule Generates Protective CD8+ T Cell Responses to Chronic Infection. Front Immunol. 2020; 11:1464. Tsitsiklis A, Bangs DJ, Lutes LK, Chan SW, Geiger KM, Modzelewski AJ, Labarta-Bajo L, Wang Y, Zuniga EI, Dai S, Robey EA. PMID: 32733483; PMCID: PMC7360836.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting. Neoplasia. 2020 02; 22(2):86-97. Gupta P, Johns SC, Kim SY, El Ghazal R, Zuniga EI, Fuster MM. PMID: 31896526; PMCID: PMC6940629.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Evasion. Cell Rep. 2019 12 03; 29(10):2979-2989.e15. Wierzbicki IH, Campeau A, Dehaini D, Holay M, Wei X, Greene T, Ying M, Sands JS, Lamsa A, Zuniga E, Pogliano K, Fang RH, LaRock CN, Zhang L, Gonzalez DJ. PMID: 31801066; PMCID: PMC6951797.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    14. T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection. J Immunol. 2019 09 15; 203(6):1509-1520. Wong KA, Harker JA, Dolgoter A, Marooki N, Zuniga EI. PMID: 31413107; PMCID: PMC8131195.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence. PLoS One. 2018; 13(7):e0201249. Wehrens EJ, Wong KA, Gupta A, Khan A, Benedict CA, Zuniga EI. PMID: 30044874; PMCID: PMC6059457.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    16. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. J Virol. 2018 06 15; 92(12). Harker JA, Wong KA, Dallari S, Bao P, Dolgoter A, Jo Y, Wehrens EJ, Macal M, Zuniga EI. PMID: 29593047; PMCID: PMC5974502.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    17. Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses. Nat Commun. 2017 04 03; 8:14830. Dallari S, Macal M, Loureiro ME, Jo Y, Swanson L, Hesser C, Ghosh P, Zuniga EI. PMID: 28368000; PMCID: PMC5382270.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    18. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 04; 18(4):422-432. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW. PMID: 28218746; PMCID: PMC5360497.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    19. TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016 10 03; 126(10):3799-3813. Lewis GM, Wehrens EJ, Labarta-Bajo L, Streeck H, Zuniga EI. PMID: 27599295; PMCID: PMC5096797.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    20. Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth. Neoplasia. 2016 05; 18(5):294-306. El Ghazal R, Yin X, Johns SC, Swanson L, Macal M, Ghosh P, Zuniga EI, Fuster MM. PMID: 27237321; PMCID: PMC4887599.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    21. Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity. 2016 Feb 16; 44(2):274-86. Taylor A, Harker JA, Chanthong K, Stevenson PG, Zuniga EI, Rudd CE. PMID: 26885856; PMCID: PMC4760122.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    22. CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells. J Immunol. 2016 Feb 15; 196(4):1900-9. Macal M, Tam MA, Hesser C, Di Domizio J, Leger P, Gilliet M, Zuniga EI. PMID: 26773151; PMCID: PMC4744517.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol. 2015 Nov; 2(1):573-97. Zuniga EI, Macal M, Lewis GM, Harker JA. PMID: 26958929; PMCID: PMC4785831.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    24. Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol. 2015 Aug 01; 195(3):1071-81. Harker JA, Wong KA, Dolgoter A, Zuniga EI. PMID: 26085685; PMCID: PMC4506854.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    25. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J Virol. 2015 May; 89(9):4809-17. Movita D, van de Garde MD, Biesta P, Kreefft K, Haagmans B, Zuniga E, Herschke F, De Jonghe S, Janssen HL, Gama L, Boonstra A, Vanwolleghem T. PMID: 25673700; PMCID: PMC4403491.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    26. Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection. Immunity. 2013 Sep 19; 39(3):548-59. Harker JA, Dolgoter A, Zuniga EI. PMID: 23993651; PMCID: PMC4701058.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    27. Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. Nat Immunol. 2012 Dec; 13(12):1162-70. Shih VF, Davis-Turak J, Macal M, Huang JQ, Ponomarenko J, Kearns JD, Yu T, Fagerlund R, Asagiri M, Zuniga EI, Hoffmann A. PMID: 23086447; PMCID: PMC3634611.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    28. T-cell exhaustion due to persistent antigen: quantity not quality? Eur J Immunol. 2012 Sep; 42(9):2285-9. Zuniga EI, Harker JA. PMID: 22949327; PMCID: PMC3684559.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host Microbe. 2012 Jun 14; 11(6):643-53. Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB. PMID: 22704624; PMCID: PMC3377981.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    30. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science. 2011 Nov 11; 334(6057):825-9. Harker JA, Lewis GM, Mack L, Zuniga EI. PMID: 21960530; PMCID: PMC3388900.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    31. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 2009 Jul 17; 31(1):145-57. Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. PMID: 19604493; PMCID: PMC3039716.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    32. In vivo conversion of BM plasmacytoid DC into CD11b+ conventional DC during virus infection. Eur J Immunol. 2008 Dec; 38(12):3388-94. Liou LY, Blasius AL, Welch MJ, Colonna M, Oldstone MB, Zuniga EI. PMID: 18979509; PMCID: PMC2897746.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    33. Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe. 2008 Oct 16; 4(4):374-86. Zuniga EI, Liou LY, Mack L, Mendoza M, Oldstone MB. PMID: 18854241; PMCID: PMC2875928.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    34. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007 Dec 14; 131(6):1124-36. Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. PMID: 18083102.
      View in: PubMed   Mentions: 524     Fields:    Translation:AnimalsCells
    35. Trypanosoma cruzi infection beats the B-cell compartment favouring parasite establishment: can we strike first? Scand J Immunol. 2007 Aug-Sep; 66(2-3):137-42. Acosta Rodriguez EV, Zuniga EI, Montes CL, Merino MC, Bermejo DA, Amezcua Vesely MC, Motran CC, Gruppi A. PMID: 17635791.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    36. Type I interferon during viral infections: multiple triggers for a multifunctional mediator. Curr Top Microbiol Immunol. 2007; 316:337-57. Zuniga EI, Hahm B, Oldstone MB. PMID: 17969455.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    37. Dendritic cell inhibition: memoirs from immunosuppressive viruses. J Infect Dis. 2006 Sep 15; 194 Suppl 1:S3-10. Trifilo MJ, Hahm B, Zuniga EI, Edelmann KH, Oldstone MB. PMID: 16921469.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    38. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J Exp Med. 2006 Aug 07; 203(8):1963-75. Lauterbach H, Zuniga EI, Truong P, Oldstone MB, McGavern DB. PMID: 16847068; PMCID: PMC2118382.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    39. A Trypanosoma cruzi antigen signals CD11b+ cells to secrete cytokines that promote polyclonal B cell proliferation and differentiation into antibody-secreting cells. Eur J Immunol. 2006 Jun; 36(6):1474-85. Montes CL, Acosta-Rodríguez EV, Mucci J, Zuniga EI, Campetella O, Gruppi A. PMID: 16688679.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    40. Depletion of immature B cells during Trypanosoma cruzi infection: involvement of myeloid cells and the cyclooxygenase pathway. Eur J Immunol. 2005 Jun; 35(6):1849-58. Zuniga E, Acosta-Rodriguez E, Merino MC, Montes C, Gruppi A. PMID: 15864778.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    41. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity. 2005 Feb; 22(2):247-57. Hahm B, Trifilo MJ, Zuniga EI, Oldstone MB. PMID: 15723812.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    42. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nat Immunol. 2004 Dec; 5(12):1227-34. Zuniga EI, McGavern DB, Pruneda-Paz JL, Teng C, Oldstone MB. PMID: 15531885; PMCID: PMC5340300.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    43. Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection. J Immunol. 2004 Jan 01; 172(1):493-502. Acosta-Rodríguez EV, Montes CL, Motrán CC, Zuniga EI, Liu FT, Rabinovich GA, Gruppi A. PMID: 14688359.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
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