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    Chantal Darquenne

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0623A
    CA La Jolla 92093
    Phone858-534-9171
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      Collapse Biography 
      Collapse Education and Training
      Université Libre de Bruxelles, BelgiumMSc1990Mechanical Engineering
      Université Libre de Bruxelles, BelgiumPhD1995Applied Sciences

      Collapse Research 
      Collapse Research Activities and Funding
      MR Imaging of Upper Airway Dynamics in Obstructive Sleep Apnea
      NIH/NHLBI R21HL121794Sep 1, 2014 - Jun 30, 2016
      Role: Principal Investigator
      Quantitative MRI-based Assessment of Aerosol Deposition in the Lung
      NIH/NHLBI R21HL087805Dec 4, 2007 - Nov 30, 2010
      Role: Principal Investigator
      Modeling of Aerosol Transport in Alveolated Airways
      NIH/NIEHS R01ES011177Aug 1, 2001 - Mar 31, 2011
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Sá RC, Zeman KL, Bennett WD, Prisk GK, Darquenne C. Regional Ventilation Is the Main Determinant of Alveolar Deposition of Coarse Particles in the Supine Healthy Human Lung During Tidal Breathing. J Aerosol Med Pulm Drug Deliv. 2017 Mar 09. PMID: 28277885.
        View in: PubMed
      2. Hopkins SR, Elliott AR, Prisk GK, Darquenne C. Ventilation heterogeneity measured by multiple breath inert gas testing is not affected by inspired oxygen concentration in healthy humans. J Appl Physiol (1985). 2017 Jun 01; 122(6):1379-1387. PMID: 28280107.
        View in: PubMed
      3. Patz MD, Sá RC, Darquenne C, Elliott AR, Asadi AK, Theilmann RJ, Dubowitz DJ, Swenson ER, Prisk GK, Hopkins SR. Susceptibility to high-altitude pulmonary edema is associated with a more uniform distribution of regional specific ventilation. J Appl Physiol (1985). 2017 Apr 01; 122(4):844-852. PMID: 28057815.
        View in: PubMed
      4. Darquenne C, Hoover MD, Phalen RF. INHALED AEROSOL DOSIMETRY: SOME CURRENT RESEARCH NEEDS. J Aerosol Sci. 2016 Sep; 99:1-5. PMID: 27493295.
        View in: PubMed
      5. Theilmann RJ, Darquenne C, Elliott AR, Bailey BA, Conrad DJ. Characterizing Lung Disease in Cystic Fibrosis with Magnetic Resonance Imaging and Airway Physiology. PLoS One. 2016; 11(6):e0157177. PMID: 27337056; PMCID: PMC4919047.
        View in: PubMed, PubMed Central
      6. Darquenne C, Lamm WJ, Fine JM, Corley RA, Glenny RW. Total and regional deposition of inhaled aerosols in supine healthy subjects and subjects with mild-to-moderate COPD. J Aerosol Sci. 2016 Sep; 99:27-39. PMID: 27493296.
        View in: PubMed
      7. Darquenne C, Fleming JS, Katz I, Martin AR, Schroeter J, Usmani OS, Venegas J, Schmid O. Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung. J Aerosol Med Pulm Drug Deliv. 2016 Apr; 29(2):107-26. PMID: 26829187; PMCID: PMC4841911 [Available on 04/01/17].
        View in: PubMed, PubMed Central
      8. Sá RC, Zeman KL, Bennett WD, Prisk GK, Darquenne C. Effect of Posture on Regional Deposition of Coarse Particles in the Healthy Human Lung. J Aerosol Med Pulm Drug Deliv. 2015 Dec; 28(6):423-31. PMID: 25826480.
        View in: PubMed
      9. Oakes JM, Marsden AL, Grandmont C, Darquenne C, Vignon-Clementel IE. Distribution of aerosolized particles in healthy and emphysematous rat lungs: comparison between experimental and numerical studies. J Biomech. 2015 Apr 13; 48(6):1147-57. PMID: 25682537; PMCID: PMC4934663.
        View in: PubMed, PubMed Central
      10. Darquenne C, Hicks CB, Malhotra A. Last Word on Viewpoint: The ongoing need for good physiological investigation: Obstructive sleep apnea in HIV patients as a paradigm. J Appl Physiol (1985). 2015 Jan 15; 118(2):251. PMID: 25593221; PMCID: PMC4839487.
        View in: PubMed, PubMed Central
      11. Darquenne C . ISAM Textbook of Aerosol Medicine. R. Dhand (ed). Deposition of Aerosols in the Lung: Deposition Mechanisms. 2015; e1-16.
      12. Finlay WH, Darquenne C . ISAM Textbook of Aerosol Medicine. R. Dhand (ed). Deposition of Aerosols in the Lungs: Particle size distributions. 2015; e1-8.
      13. Thompson RB, Darquenne C . ISAM Textbook of Aerosol Medicine. R. Dhand (ed). Magnetic Resonance Imaging of Aerosol Deposition. 2015; e1-20.
      14. Darquenne C, Borja MG, Oakes JM, Breen EC, Olfert IM, Scadeng M, Prisk GK. Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity. J Appl Physiol (1985). 2014 Oct 15; 117(8):880-6. PMID: 25170069; PMCID: PMC4199993.
        View in: PubMed, PubMed Central
      15. Darquenne C, Hicks CB, Malhotra A. The ongoing need for good physiological investigation: obstructive sleep apnea in HIV patients as a paradigm. J Appl Physiol (1985). 2015 Jan 15; 118(2):244-6. PMID: 25150224; PMCID: PMC4315452.
        View in: PubMed, PubMed Central
      16. Darquenne C. Aerosol deposition in the human lung in reduced gravity. J Aerosol Med Pulm Drug Deliv. 2014 Jun; 27(3):170-7. PMID: 24870702; PMCID: PMC4088354.
        View in: PubMed, PubMed Central
      17. Oakes JM, Breen EC, Scadeng M, Tchantchou GS, Darquenne C. MRI-based measurements of aerosol deposition in the lung of healthy and elastase-treated rats. J Appl Physiol (1985). 2014 Jun 15; 116(12):1561-8. PMID: 24790020; PMCID: PMC4064380.
        View in: PubMed, PubMed Central
      18. Sá RC, Asadi AK, Theilmann RJ, Hopkins SR, Prisk GK, Darquenne C. Validating the distribution of specific ventilation in healthy humans measured using proton MR imaging. J Appl Physiol (1985). 2014 Apr 15; 116(8):1048-56. PMID: 24505099; PMCID: PMC4035784.
        View in: PubMed, PubMed Central
      19. Oakes JM, Marsden AL, Grandmont C, Shadden SC, Darquenne C, Vignon-Clementel IE. Airflow and particle deposition simulations in health and emphysema: from in vivo to in silico animal experiments. Ann Biomed Eng. 2014 Apr; 42(4):899-914. PMID: 24318192; PMCID: PMC4092242.
        View in: PubMed, PubMed Central
      20. Prisk GK, Sá RC, Darquenne C. Cardiogenic mixing increases aerosol deposition in the human lung in the absence of gravity. Acta Astronaut. 2013 Nov; 92(1):15-20. PMID: 23976801.
        View in: PubMed
      21. Darquenne C, Zeman KL, Sá RC, Cooper TK, Fine JM, Bennett WD, Prisk GK. Removal of sedimentation decreases relative deposition of coarse particles in the lung periphery. J Appl Physiol (1985). 2013 Aug 15; 115(4):546-55. PMID: 23743403.
        View in: PubMed
      22. Darquenne C, Prisk GK. Particulate deposition in the human lung under lunar habitat conditions. Aviat Space Environ Med. 2013 Mar; 84(3):190-5. PMID: 23513279.
        View in: PubMed
      23. Oakes JM, Scadeng M, Breen EC, Prisk GK, Darquenne C. Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging. Ann Biomed Eng. 2013 May; 41(5):967-78. PMID: 23354670; PMCID: PMC3625510.
        View in: PubMed, PubMed Central
      24. Ma B, Darquenne C. Aerosol bolus dispersion in acinar airways--influence of gravity and airway asymmetry. J Appl Physiol (1985). 2012 Aug; 113(3):442-50. PMID: 22678957; PMCID: PMC3426167.
        View in: PubMed, PubMed Central
      25. Darquenne C. Aerosol deposition in health and disease. J Aerosol Med Pulm Drug Deliv. 2012 Jun; 25(3):140-7. PMID: 22686623; PMCID: PMC3417302.
        View in: PubMed, PubMed Central
      26. Oakes JM, Scadeng M, Breen EC, Marsden AL, Darquenne C. Rat airway morphometry measured from in situ MRI-based geometric models. J Appl Physiol (1985). 2012 Jun; 112(11):1921-31. PMID: 22461437; PMCID: PMC3379152.
        View in: PubMed, PubMed Central
      27. Darquenne C, van Ertbruggen C, Prisk GK. Convective flow dominates aerosol delivery to the lung segments. J Appl Physiol (1985). 2011 Jul; 111(1):48-54. PMID: 21474695; PMCID: PMC3137542.
        View in: PubMed, PubMed Central
      28. Ma B, Darquenne C. Aerosol deposition characteristics in distal acinar airways under cyclic breathing conditions. J Appl Physiol (1985). 2011 May; 110(5):1271-82. PMID: 21330617; PMCID: PMC3098659.
        View in: PubMed, PubMed Central
      29. Moore GS, Wong SC, Darquenne C, Neuman TS, West JB, Kim Prisk G. Ventilation-perfusion inequality in the human lung is not increased following no-decompression-stop hyperbaric exposure. Eur J Appl Physiol. 2009 Nov; 107(5):545-52. PMID: 19690884; PMCID: PMC2767514.
        View in: PubMed, PubMed Central
      30. Darquenne C, Harrington L, Prisk GK. Alveolar duct expansion greatly enhances aerosol deposition: a three-dimensional computational fluid dynamics study. Philos Trans A Math Phys Eng Sci. 2009 Jun 13; 367(1896):2333-46. PMID: 19414458; PMCID: PMC2696106.
        View in: PubMed, PubMed Central
      31. Ma B, Ruwet V, Corieri P, Theunissen R, Riethmuller M, Darquenne C. CFD Simulation and Experimental Validation of Fluid Flow and Particle Transport in a Model of Alveolated Airways. J Aerosol Sci. 2009 May; 40(5):403-141. PMID: 20161301.
        View in: PubMed
      32. Peterson JB, Prisk GK, Darquenne C. Aerosol deposition in the human lung periphery is increased by reduced-density gas breathing. J Aerosol Med Pulm Drug Deliv. 2008 Jun; 21(2):159-68. PMID: 18518792; PMCID: PMC3193060.
        View in: PubMed, PubMed Central
      33. Darquenne C, Prisk GK. Deposition of inhaled particles in the human lung is more peripheral in lunar than in normal gravity. Eur J Appl Physiol. 2008 Aug; 103(6):687-95. PMID: 18488244.
        View in: PubMed
      34. van Ertbruggen C, Corieri P, Theunissen R, Riethmuller ML, Darquenne C. Validation of CFD predictions of flow in a 3D alveolated bend with experimental data. J Biomech. 2008; 41(2):399-405. PMID: 17915225; PMCID: PMC2290742.
        View in: PubMed, PubMed Central
      35. Harrington L, Prisk GK, Darquenne C . Importance of the bifurcation zone and branch orientation in simulated aerosol deposition in the alveolar zone of the human lung. Journal of Aerosol Science. 2006; 37:37-62.
      36. Darquenne C . Encyclopedia of Respiratory Medicine. Laurent GJ, Shapiro SD, editors. Particle deposition in the lung. 2006; 300-303.
      37. Darquenne C, Prisk GK. Aerosols in the study of convective acinar mixing. Respir Physiol Neurobiol. 2005 Aug 25; 148(1-2):207-16. PMID: 15890563; PMCID: PMC1199522.
        View in: PubMed, PubMed Central
      38. Dutrieue B, Verbanck S, Darquenne C, Prisk GK. Airway closure in microgravity. Respir Physiol Neurobiol. 2005 Aug 25; 148(1-2):97-111. PMID: 15979418.
        View in: PubMed
      39. Darquenne C, Prisk GK. Effect of small flow reversals on aerosol mixing in the alveolar region of the human lung. J Appl Physiol (1985). 2004 Dec; 97(6):2083-9. PMID: 15298988.
        View in: PubMed
      40. Darquenne C, Prisk GK. Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox. J Aerosol Med. 2004; 17(3):278-85. PMID: 15625820; PMCID: PMC1266295.
        View in: PubMed, PubMed Central
      41. Darquenne C, Prisk GK. Effect of gravitational sedimentation on simulated aerosol dispersion in the human acinus. J Aerosol Sci. 2003 Apr; 34(4):405-18. PMID: 12747364.
        View in: PubMed
      42. Dutrieue B, Paiva M, Verbanck S, Le Gouic M, Darquenne C, Prisk GK. Tidal volume single-breath washin of SF6 and CH4 in transient microgravity. J Appl Physiol (1985). 2003 Jan; 94(1):75-82. PMID: 12391087.
        View in: PubMed
      43. Mills CN, Darquenne C, Prisk GK. Mode shift of an inhaled aerosol bolus is correlated with flow sequencing in the human lung. J Appl Physiol (1985). 2002 Mar; 92(3):1232-8. PMID: 11842063.
        View in: PubMed
      44. Darquenne C . Heterogeneity of aerosol deposition in a two-dimensional model of human alveolated airways. Journal of Aerosol Science. 2002; 33:1261-1278.
      45. Darquenne C . Gravity and the Lung: Lessons from Microgravity. Prisk GK, Paiva M, West JB, editors. Chapter 5: Aerosol Transport in the Lung. 2001; 117-148.
      46. Darquenne C . A realistic two-dimensional model of aerosol transport and deposition in the alveolar zone of the human lung. Journal of Aerosol Science. 2001; 32:1161-1174.
      47. Darquenne C, Paiva M, Prisk GK. Effect of gravity on aerosol dispersion and deposition in the human lung after periods of breath holding. J Appl Physiol (1985). 2000 Nov; 89(5):1787-92. PMID: 11053327.
        View in: PubMed
      48. Darquenne C, West JB, Prisk GK. Dispersion of 0.5- to 2-micron aerosol in microG and hypergravity as a probe of convective inhomogeneity in the lung. J Appl Physiol (1985). 1999 Apr; 86(4):1402-9. PMID: 10194229.
        View in: PubMed
      49. Verbanck S, Darquenne C, Prisk GK, Vincken W, Paiva M. A source of experimental underestimation of aerosol bolus deposition. J Appl Physiol (1985). 1999 Mar; 86(3):1067-74. PMID: 10066725.
        View in: PubMed
      50. Darquenne C, West JB, Prisk GK. Deposition and dispersion of 1-micrometer aerosol boluses in the human lung: effect of micro- and hypergravity. J Appl Physiol (1985). 1998 Oct; 85(4):1252-9. PMID: 9760313.
        View in: PubMed
      51. Darquenne C, Paiva M. Complexities in Structure and Function of the Lung. Hlastala MP, Robertson HT, editors. Chapter 10: Gas and Particle Transport in the Lung. 1998; 297-323.
      52. Darquenne C, Paiva M, West JB, Prisk GK. Effect of microgravity and hypergravity on deposition of 0.5- to 3-micron-diameter aerosol in the human lung. J Appl Physiol (1985). 1997 Dec; 83(6):2029-36. PMID: 9390977.
        View in: PubMed
      53. Darquenne C, Brand P, Heyder J, Paiva M. Aerosol dispersion in human lung: comparison between numerical simulations and experiments for bolus tests. J Appl Physiol (1985). 1997 Sep; 83(3):966-74. PMID: 9292486.
        View in: PubMed
      54. Darquenne C, Paiva M. Two- and three-dimensional simulations of aerosol transport and deposition in alveolar zone of human lung. J Appl Physiol (1985). 1996 Apr; 80(4):1401-14. PMID: 8926273.
        View in: PubMed
      55. Darquenne C, Paiva M. One-dimensional simulation of aerosol transport and deposition in the human lung. J Appl Physiol (1985). 1994 Dec; 77(6):2889-98. PMID: 7896637.
        View in: PubMed
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