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    George Sen

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentDermatology
    Address9500 Gilman Drive #0869
    CA La Jolla 92093
    Phone858-246-0268
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      Collapse Overview 
      Collapse Overview
      Our research is focused on understanding the molecular mechanisms of epidermal stem cell self-renewal and differentiation. Understanding the factors that govern this process is extremely important as perturbations in this intricate balance between growth and differentiation can lead to a variety of human skin disorders. Increased proliferation and diminished differentiation can lead to hyperproliferative disorders such as psoriasis, basal or squamous cell carcinomas. Thus, a comprehensive understanding of the regulators of epidermal stem cell self-renewal and differentiation would be key to unlocking the molecular mechanisms underlying skin disorders and the possibility of developing better treatment for these debilitating disorders. We have focused on identifying epigenetic factors that have functional roles in promoting epidermal stem cell self-renewal and differentiation. Our research in the future will continue to focus on identifying and characterizing novel regulators of epidermal homeostasis. Our ultimate goal is to define all the regulators that are important for stem cell self-renewal, differentiation, and tumorigenesis.

      Research Focus Areas:

    • Developmental Biology

    • Genetics and Genomics

    • Gene Expression and Regulation

    • Stem Cell Biology



    • Collapse Research 
      Collapse Research Activities and Funding
      Post-Trancriptional Regulation of Epidermal Stem and Progenitor Cell Self-Renewal
      NIH/NIAMS R56AR070729Sep 5, 2017 - Aug 31, 2018
      Role: Principal Investigator
      Limbal Stem Cell Fate and Corneal Specific Enhancers
      NIH/NEI R01EY025090Apr 1, 2015 - Mar 31, 2020
      Role: Principal Investigator
      Regulators of Epidermal Growth and Differentiation
      NIH/NIAMS R01AR066530Feb 17, 2015 - Dec 31, 2019
      Role: Principal Investigator
      Epigenetic Regulators in Epidermal Homeostasis and Neoplasia
      NIH/NIAMS K01AR057828Feb 3, 2010 - Nov 30, 2014
      Role: Principal Investigator
      Role of Polycomb Group Proteins in Epidermal Diffentiation
      NIH/NIAMS F32AR055849Jul 1, 2008 - Jun 30, 2011
      Role: Principal Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Noutsou M, Li J, Ling J, Jones J, Wang Y, Chen Y, Sen G. The Cohesin Complex Is Necessary for Epidermal Progenitor Cell Function through Maintenance of Self-Renewal Genes. Cell Rep. 2017 Sep 26; 20(13):3005-3013. PMID: 28954219.
        View in: PubMed
      2. Wang Y, Sen G. Enhanc(er)ing Skin Stem Cells. Cell Stem Cell. 2016 10 06; 19(4):415-417. PMID: 27716517.
        View in: PubMed
      3. Zhang LJ, Sen G, Ward NL, Johnston A, Chun K, Chen Y, Adase C, Sanford JA, Gao N, Chensee M, Sato E, Fritz Y, Baliwag J, Williams MR, Hata T, Gallo RL. Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-ß Production by Epidermal Keratinocytes during Skin Injury. Immunity. 2016 Jul 19; 45(1):119-30. PMID: 27438769; PMCID: PMC4957248 [Available on 07/19/17].
      4. Li J, Sen G. Post-Transcriptional Mechanisms Regulating Epidermal Stem and Progenitor Cell Self-Renewal and Differentiation. J Invest Dermatol. 2016 Apr; 136(4):746-52. PMID: 26875726.
        View in: PubMed
      5. Li J, Sen G. Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis. J Vis Exp. 2015 Dec 14; (106):e53280. PMID: 26709715.
        View in: PubMed
      6. Wang Y, Arribas-Layton M, Chen Y, Lykke-Andersen J, Sen G. DDX6 Orchestrates Mammalian Progenitor Function through the mRNA Degradation and Translation Pathways. Mol Cell. 2015 Oct 01; 60(1):118-30. PMID: 26412305; PMCID: PMC4592480 [Available on 10/01/16].
      7. Mistry DS, Chen Y, Wang Y, Sen G. Transcriptional profiling of SNAI2 regulated genes in primary human keratinocytes. Genom Data. 2015 Jun 01; 4:43-46. PMID: 25793155.
        View in: PubMed
      8. Mistry DS, Chen Y, Wang Y, Zhang K, Sen G. SNAI2 controls the undifferentiated state of human epidermal progenitor cells. Stem Cells. 2014 Dec; 32(12):3209-18. PMID: 25100569; PMCID: PMC4339269.
      9. Chen Y, Mistry DS, Sen G. Highly rapid and efficient conversion of human fibroblasts to keratinocyte-like cells. J Invest Dermatol. 2014 Feb; 134(2):335-344. PMID: 23921950; PMCID: PMC3875612.
      10. Mistry DS, Chen Y, Sen G. Progenitor function in self-renewing human epidermis is maintained by the exosome. Cell Stem Cell. 2012 Jul 06; 11(1):127-35. PMID: 22770246; PMCID: PMC3392610.
      11. Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen G, Deftos LJ, Gallo RL. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012 May 23; 4(135):135ra66. PMID: 22623742; PMCID: PMC3725981.
      12. Sen G. Remembering one's identity: the epigenetic basis of stem cell fate decisions. FASEB J. 2011 Jul; 25(7):2123-8. PMID: 21441350.
        View in: PubMed
      13. Sen G, Reuter JA, Webster DE, Zhu L, Khavari PA. DNMT1 maintains progenitor function in self-renewing somatic tissue. Nature. 2010 Jan 28; 463(7280):563-7. PMID: 20081831; PMCID: PMC3050546.
      14. Sen G, Blau HM. A brief history of RNAi: the silence of the genes. FASEB J. 2006 Jul; 20(9):1293-9. PMID: 16816104.
        View in: PubMed
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