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Richard Clark

TitleProfessor Of Clinical
InstitutionUniversity of California San Diego
DepartmentEmergency Medical Services
Address200 W. Arbor Drive #8676
San Diego CA 92103
Phone619-543-6463
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Correia MS, Clark R. Recurrent Diffuse Large B-Cell Lymphoma Presenting with Pancoast Syndrome: A Rare Cause of Radicular Neck Pain in the Emergency Department. J Emerg Med. 2018 Jul 23. PMID: 30049430.
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    2. Myatt T, Nguyen BJ, Clark R, Coffey CH, O'Connell CW. A Prospective Study of Stingray Injury and Envenomation Outcomes. J Emerg Med. 2018 May 23. PMID: 29803633.
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    3. Ni A, Lee Cantrell F, Clark R. Ketamine exposure demographics and outcomes over 16?years as reported to US poison centers. Am J Emerg Med. 2018 May 03. PMID: 29754964.
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    4. Sun C, Brice JA, Clark R. Brugada-Type Pattern on Electrocardiogram Associated with High-Dose Loperamide Abuse. J Emerg Med. 2018 Apr; 54(4):484-486. PMID: 29439890.
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    5. Korepanova A, Longenecker KL, Pratt SD, Panchal SC, Clark R, Lake M, Gopalakrishnan SM, Raich D, Sun C, Petros AM. Fragment-based discovery of a potent NAMPT inhibitor. Bioorg Med Chem Lett. 2017 Dec 12. PMID: 29287958.
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    6. Curtin ML, Heyman HR, Clark R, Sorensen BK, Doherty GA, Hansen TM, Frey RR, Sarris KA, Aguirre AL, Shrestha A, Tu N, Woller K, Pliushchev MA, Sweis RF, Cheng M, Wilsbacher JL, Kovar PJ, Guo J, Cheng D, Longenecker KL, Raich D, Korepanova AV, Soni NB, Algire MA, Richardson PL, Marin VL, Badagnani I, Vasudevan A, Buchanan FG, Maag D, Chiang GG, Tse C, Michaelides MR. SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2017 08 01; 27(15):3317-3325. PMID: 28610984.
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    7. Wilsbacher JL, Cheng M, Cheng D, Trammell SAJ, Shi Y, Guo J, Koeniger SL, Kovar PJ, He Y, Selvaraju S, Heyman HR, Sorensen BK, Clark R, Hansen TM, Longenecker KL, Raich D, Korepanova AV, Cepa S, Towne DL, Abraham VC, Tang H, Richardson PL, McLoughlin SM, Badagnani I, Curtin ML, Michaelides MR, Maag D, Buchanan FG, Chiang GG, Gao W, Rosenberg SH, Brenner C, Tse C. Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Mol Cancer Ther. 2017 Jul; 16(7):1236-1245. PMID: 28468779.
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    8. Corbett B, Clark R. North American Snake Envenomation. Emerg Med Clin North Am. 2017 May; 35(2):339-354. PMID: 28411931.
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    9. Koch RA, Clark R. Euglycemic Ketoacidosis With Sodium-Glucose Cotransporter-2 Inhibitor. Am J Ther. 2017 Apr 25. PMID: 28452848.
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    10. Clark AT, Clark R, Cantrell FL. A Retrospective Review of the Presentation and Treatment of Stingray Stings Reported to a Poison Control System. Am J Ther. 2017 Mar/Apr; 24(2):e177-e180. PMID: 26866435.
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    11. Curtin ML, Pliushchev MA, Li HQ, Torrent M, Dietrich JD, Jakob CG, Zhu H, Zhao H, Wang Y, Ji Z, Clark R, Sarris KA, Selvaraju S, Shaw B, Algire MA, He Y, Richardson PL, Sweis RF, Sun C, Chiang GG, Michaelides MR. SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg Med Chem Lett. 2017 04 01; 27(7):1576-1583. PMID: 28254486.
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    12. Carstairs SD, Minns AB, Clark R, Tomaszewski CA. In Reply: "Single Versus Multiple Hyperbaric Sessions for Carbon Monoxide Poisoning in a Murine Model". J Med Toxicol. 2017 Mar; 13(1):129. PMID: 27699639.
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    13. Lasoff DR, Ruha AM, Curry SC, Koh C, Clark R. A new F(ab')2 antivenom for the treatment of crotaline envenomation in children. Am J Emerg Med. 2016 Oct; 34(10):2003-2006. PMID: 27567423.
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    14. Carstairs SD, Miller AD, Minns AB, Duchnick J, Riffenburgh RH, Clark R, Tomaszewski CA. Single Versus Multiple Hyperbaric Sessions for Carbon Monoxide Poisoning in a Murine Model. J Med Toxicol. 2016 Dec; 12(4):386-390. PMID: 27456263.
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    15. Thornton SL, Liu J, Soleymani K, Romasco RL, Farid H, Clark R, Cantrell FL. Review of Experience of a Statewide Poison Control Center With Pediatric Exposures to Oral Antineoplastic Drugs in the Nonmedical Setting. Am J Ther. 2016 Mar-Apr; 23(2):e377-81. PMID: 23884076.
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    16. Nordt SP, Clark R, Machado C, Cantrell FL. Assessment of Digoxin-Specific Fab Fragment Dosages in Digoxin Poisoning. Am J Ther. 2016 Jan-Feb; 23(1):e63-7. PMID: 25379735.
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    17. Villarreal J, Kahn CA, Dunford JV, Castillo EM, Clark R. Prehospital activated charcoal use in antipsychotic overdose. Am J Emerg Med. 2016 Feb; 34(2):316-7. PMID: 26612705.
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    18. Villano JH, O'Connell CW, Clark R. Prolonged, reversible neurologic symptoms after carpet sea anemone envenomation in a pet store worker. Clin Toxicol (Phila). 2015 Feb; 53(2):137. PMID: 25608794.
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    19. Clark R, O'Connell CW, Villano JH, Kim A, Ly BT, Minns AB. Severe recurrent coagulopathy following crotaline envenomation refractory to maintenance dosing of antivenom. Am J Emerg Med. 2015 Jun; 33(6):856.e3-5. PMID: 25524360.
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    20. Bush SP, Ruha AM, Seifert SA, Morgan DL, Lewis BJ, Arnold TC, Clark R, Meggs WJ, Toschlog EA, Borron SW, Figge GR, Sollee DR, Shirazi FM, Wolk R, de Chazal I, Quan D, García-Ubbelohde W, Alagón A, Gerkin RD, Boyer LV. Comparison of F(ab')2 versus Fab antivenom for pit viper envenomation: a prospective, blinded, multicenter, randomized clinical trial. Clin Toxicol (Phila). 2015 Jan; 53(1):37-45. PMID: 25361165; PMCID: PMC4364250.
    21. Villarreal J, Kahn CA, Dunford JV, Patel E, Clark R. A retrospective review of the prehospital use of activated charcoal. Am J Emerg Med. 2015 Jan; 33(1):56-9. PMID: 25455049.
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    22. Thornton SL, Clark R. Encephalopathy from unintentional donepezil and memantine ingestion. Pediatr Emerg Care. 2014 Sep; 30(9):649-50. PMID: 25186510.
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    23. Cantrell FL, Clark R. More on nicotine poisoning in infants. N Engl J Med. 2014 08 28; 371(9):880. PMID: 25162905.
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    24. Nordt SP, Rangan C, Hardmaslani M, Clark R, Wendler C, Valente M. Pediatric chloral hydrate poisonings and death following outpatient procedural sedation. J Med Toxicol. 2014 Jun; 10(2):219-22. PMID: 24532346; PMCID: PMC4057536.
    25. Heard K, Bui A, Mlynarchek SL, Green JL, Bond GR, Clark R, Kozer E, Koff RS, Dart RC. Toxicity from repeated doses of acetaminophen in children: assessment of causality and dose in reported cases. Am J Ther. 2014 May-Jun; 21(3):174-83. PMID: 22407198; PMCID: PMC3374904.
    26. Stevenson JW, Minns AB, Smollin C, Albertson TE, Cantrell FL, Tomaszewski C, Clark R. An observational case series of dabigatran and rivaroxaban exposures reported to a poison control system. Am J Emerg Med. 2014 Sep; 32(9):1077-84. PMID: 24908445.
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    27. Darracq MA, Clark R, Jacoby I, Vilke GM, DeMers G, Cantrell FL. Disaster preparedness of poison control centers in the USA: a 15-year follow-up study. J Med Toxicol. 2014 Mar; 10(1):19-25. PMID: 23842905; PMCID: PMC3951635.
    28. Lo JC, Darracq MA, Clark R. A review of methylene blue treatment for cardiovascular collapse. J Emerg Med. 2014 May; 46(5):670-9. PMID: 24508113.
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    29. Clark R, Hayden SR. The emergence of concierge emergency medicine. J Emerg Med. 2013 Dec; 45(6):915-6. PMID: 24055282.
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    30. Hawley LA, Auten JD, Matteucci MJ, Decker L, Hurst N, Beer W, Clark R. Cardiac complications of adult methamphetamine exposures. J Emerg Med. 2013 Dec; 45(6):821-7. PMID: 24054881.
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    31. Darracq MA, Thornton SL, Do HM, Bok D, Clark R, Cantrell FL. Utilization of hyperinsulinemia euglycemia and intravenous fat emulsion following poison center recommendations. J Med Toxicol. 2013 Sep; 9(3):226-30. PMID: 23412936; PMCID: PMC3770986.
    32. Schneir AB, Rentmeester L, Clark R, Cantrell FL. Toxicity following laundry detergent pod ingestion. Pediatr Emerg Care. 2013 Jun; 29(6):741-2. PMID: 23736068.
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    33. Schneir AB, Clark R. Death caused by ingestion of an ethanol-based hand sanitizer. J Emerg Med. 2013 Sep; 45(3):358-60. PMID: 23706595.
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    34. Minns AB, McIlvoy A, Clark A, Clark R, Cantrell FL. Examining the risk of methanol poisoning from methyl acetate-containing products. Am J Emerg Med. 2013 Jun; 31(6):964-6. PMID: 23602747.
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    35. Darracq MA, Ward NT, Tomaszewski C, Clark R. In reply. Ann Emerg Med. 2013 Feb; 61(2):254-5. PMID: 23331653.
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    36. Darracq MA, Rentmeester LL, Clark R, Tomaszewski CA, Schneir AB, Cantrell FL. Cost of hemodialysis versus fomepizole-only for treatment of ethylene glycol intoxication. Clin Toxicol (Phila). 2013 Mar; 51(3):188. PMID: 23356815.
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    37. Thornton SL, Lo J, Clark R, Wu AH, Gerona RR. Simultaneous detection of multiple designer drugs in serum, urine, and CSF in a patient with prolonged psychosis. Clin Toxicol (Phila). 2012 Dec; 50(10):1165-8. PMID: 23163617.
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    38. Nordt SP, Vilke GM, Clark R, Lee Cantrell F, Chan TC, Galinato M, Nguyen V, Castillo EM. Energy drink use and adverse effects among emergency department patients. J Community Health. 2012 Oct; 37(5):976-81. PMID: 22367607.
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    39. Kreshak AA, Cantrell FL, Clark R, Tomaszewski CA. A poison center's ten-year experience with flumazenil administration to acutely poisoned adults. J Emerg Med. 2012 Oct; 43(4):677-82. PMID: 22766408.
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    40. Thornton SL, Nguyen KT, Shenn SK, Castillo EM, Clark R, Cantrell FL. A retrospective review of early gastrointestinal symptoms in the prediction of crotaline envenomation severity. Wilderness Environ Med. 2012 Dec; 23(4):360-2. PMID: 22727676.
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    41. Ward NT, Darracq MA, Tomaszewski C, Clark R. Evidence-based treatment of jellyfish stings in North America and Hawaii. Ann Emerg Med. 2012 Oct; 60(4):399-414. PMID: 22677532.
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    42. Kreshak AA, Tomaszewski CA, Clark R, Cantrell FL. Flumazenil administration in poisoned pediatric patients. Pediatr Emerg Care. 2012 May; 28(5):448-50. PMID: 22531190.
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    43. Minns AB, Clark R. Toxicology and overdose of atypical antipsychotics. J Emerg Med. 2012 Nov; 43(5):906-13. PMID: 22555052.
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    44. Auten JD, Matteucci MJ, Gaspary MJ, Combs DJ, Clark R. Psychiatric implications of adolescent methamphetamine exposures. Pediatr Emerg Care. 2012 Jan; 28(1):26-9. PMID: 22193694.
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    45. Nordt SP, Clark R, Lee A, Berk K, Lee Cantrell F. Examination of adverse events following black widow antivenom use in California. Clin Toxicol (Phila). 2012 Jan; 50(1):70-3. PMID: 22175789.
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    46. Nordt SP, Clark R, Castillo EM, Guss DA. Comparison of three aspirin formulations in human volunteers. West J Emerg Med. 2011 Nov; 12(4):381-5. PMID: 22224124; PMCID: PMC3236147.
    47. Nordt SP, Chen J, Clark R. Severe hypermagnesemia after enteral administration of Epsom salts. Am J Health Syst Pharm. 2011 Aug 01; 68(15):1384-5. PMID: 21785020.
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    48. Nordt SP, Minns A, Carstairs S, Kreshak A, Campbell C, Tomaszweski C, Hayden SR, Clark R, Joshua A, Ly BT. Mass sociogenic illness initially reported as carbon monoxide poisoning. J Emerg Med. 2012 Feb; 42(2):159-61. PMID: 21658882.
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    49. Nordt SP, Campbell C, Medak A, Tomaszweski C, Clark R. Ultrasound visualization of ingested tablets: a pilot study. Pharmacotherapy. 2011 Mar; 31(3):273-6. PMID: 21361737.
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    50. Offerman SR, Daubert GP, Clark R. The treatment of black widow spider envenomation with antivenin latrodectus mactans: a case series. Perm J. 2011; 15(3):76-81. PMID: 22058673; PMCID: PMC3200105.
    51. Minns AB, McFarland C, Strachan M, Austin W, Castillo E, Ben-Yehuda O, Clark R. Electrocardiogram and echocardiogram findings in runners completing a half marathon. Am J Emerg Med. 2011 Nov; 29(9):1182-7. PMID: 20934826.
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    52. Nordt SP, Scaduto L, Clark R, Cantrell FL. Retrospective review of acute acamprosate exposures to a poison control system. Am J Addict. 2010 Sep-Oct; 19(5):462-3. PMID: 20716311.
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    53. Carstairs SD, Urquhart A, Hoffman J, Clark R, Cantrell FL. A retrospective review of supratherapeutic modafinil exposures. J Med Toxicol. 2010 Sep; 6(3):307-10. PMID: 20358418; PMCID: PMC2929436.
    54. Miller AD, Young MC, DeMott MC, Ly BT, Clark R. Recurrent coagulopathy and thrombocytopenia in children treated with crotalidae polyvalent immune fab: a case series. Pediatr Emerg Care. 2010 Aug; 26(8):576-82. PMID: 20693856.
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    55. Kreshak AA, Clark R. Transient vision loss in a patient with metformin-associated lactic acidosis. Am J Emerg Med. 2010 Nov; 28(9):1059.e5-7. PMID: 20627210.
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    56. Bebarta VS, Kao L, Froberg B, Clark R, Lavonas E, Qi M, Delgado J, McDonagh J, Arnold T, Odujebe O, O'Malley G, Lares C, Aguilera E, Dart R, Heard K, Stanford C, Kokko J, Bogdan G, Mendoza C, Mlynarchek S, Rhyee S, Hoppe J, Haur W, Tan HH, Tran NN, Varney S, Zosel A, Buchanan J, Al-Helial M. A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose. Clin Toxicol (Phila). 2010 Jun; 48(5):424-30. PMID: 20524832; PMCID: PMC2894984.
    57. Minns AB, Ghafouri N, Clark R. Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy. Pediatr Emerg Care. 2010 May; 26(5):380-1. PMID: 20453796.
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    58. Minns AB, Carstairs SD, Clark R. "Caustic cocktail": closed-circuit diving apparatus contamination leading to corrosive injury. Am J Emerg Med. 2010 Sep; 28(7):843.e3-5. PMID: 20837270.
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    59. Soroudi A, Clark R. Worsening gait abnormalities in a 12-year-old child. J Emerg Med. 2012 Mar; 42(3):304-5. PMID: 20363579.
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    60. Minns AB, Cantrell FL, Clark R. Death due to acute salicylate intoxication despite dialysis. J Emerg Med. 2011 May; 40(5):515-7. PMID: 20347249.
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    61. Fidanze SD, Erickson SA, Wang GT, Mantei R, Clark R, Sorensen BK, Bamaung NY, Kovar P, Johnson EF, Swinger KK, Stewart KD, Zhang Q, Tucker LA, Pappano WN, Wilsbacher JL, Wang J, Sheppard GS, Bell RL, Davidsen SK, Hubbard RD. Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases. Bioorg Med Chem Lett. 2010 Apr 15; 20(8):2452-5. PMID: 20346655.
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    62. Vohra R, Salazar A, Cantrell FL, Fernando R, Clark R. The poison pen: bedside diagnosis of urinary diquat. J Med Toxicol. 2010 Mar; 6(1):35-6. PMID: 20229151; PMCID: PMC2861174.
    63. Minns AB, Clark R, Schneir A. Guanfacine overdose resulting in initial hypertension and subsequent delayed, persistent orthostatic hypotension. Clin Toxicol (Phila). 2010 Feb; 48(2):146-8. PMID: 20136479.
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    64. Nordt SP, Minns A, Tomaszewski C, Cantrell FL, Clark R. Retrospective review of digoxin exposures to a poison control system following recall of Digitek® tablets. Am J Cardiovasc Drugs. 2010; 10(4):261-3. PMID: 20653332.
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    65. Betten DP, Burner EE, Thomas SC, Tomaszewski C, Clark R. A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning. J Med Toxicol. 2009 Dec; 5(4):183-90. PMID: 19876849; PMCID: PMC3550405.
    66. Kreshak AA, Clark AK, Clark R, Ly BT, Cantrell FL. A retrospective poison center review of varenicline-exposed patients. Ann Pharmacother. 2009 Dec; 43(12):1986-91. PMID: 19934384.
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    67. Carstairs SD, Clark R. Atrioventricular block due to acute ethanol intoxication. J Emerg Med. 2011 Sep; 41(3):298-300. PMID: 19879087.
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    68. Vohra R, Seefeld A, Cantrell FL, Clark R. Salvia divinorum: exposures reported to a statewide poison control system over 10 years. J Emerg Med. 2011 Jun; 40(6):643-50. PMID: 19765944.
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    69. Minns AB, Ebrahimi S, Te L, Ly B, Clark R, Cantrell FL. A retrospective review of California poison control system data of sibutramine exposures. Clin Toxicol (Phila). 2009 Sep; 47(8):814-7. PMID: 19778191.
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    70. Clark R, Ly B, Schneir A, Cantrell FL, Tomaszewski C, Tanen DA. More discussion of over the counter cough and cold preparations. Ann Emerg Med. 2009 Aug; 54(2):309-10. PMID: 19616731.
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    71. Scott CI, Koenig M, Carstairs SD, Clark R. Caustic injury due to unintentional ingestion of a cooking adjunct. J Emerg Med. 2011 Jun; 40(6):e119-20. PMID: 19596178.
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    72. Nordt SP, Wu J, Zahller S, Clark R, Cantrell FL. Palytoxin poisoning after dermal contact with zoanthid coral. J Emerg Med. 2011 Apr; 40(4):397-9. PMID: 19545971.
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    73. O'Brien NF, DeMott MC, Suchard JR, Clark R, Peterson BM. Recurrent coagulopathy with delayed significant bleeding after crotaline envenomation. Pediatr Emerg Care. 2009 Jul; 25(7):457-9. PMID: 19606002.
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    74. Vohra R, Kelner M, Clark R. Preparation of crotaline F-ab antivenom (CroFab) with automated mixing methods: in vitro observations. Clin Toxicol (Phila). 2009 Jan; 47(1):69-71. PMID: 19153853.
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    75. Offerman SR, Barry JD, Richardson WH, Tong T, Tanen D, Bush SP, Clark R. Subcutaneous Crotaline Fab antivenom for the treatment of rattlesnake envenomation in a porcine model. Clin Toxicol (Phila). 2009 Jan; 47(1):61-8. PMID: 19153852.
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    76. Minns AB, Clark R. Electrocardiogram (ECG) changes and cardiac biomarker abnormalities among two marathon runners. J Emerg Med. 2010 Feb; 38(2):159-61. PMID: 19081703.
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    77. Hayes BD, Klein-Schwartz W, Clark R, Muller AA, Miloradovich JE. Comparison of toxicity of acute overdoses with citalopram and escitalopram. J Emerg Med. 2010 Jul; 39(1):44-8. PMID: 19081700.
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    78. Schneir A, Clark R, Kene M, Betten D. Systemic fluoride poisoning and death from inhalational exposure to sulfuryl fluoride. Clin Toxicol (Phila). 2008 Nov; 46(9):850-4. PMID: 18608259.
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    79. Clark R, Cantrell FL, Pacal A, Chen W, Betten DP. Subcutaneous silicone injection leading to multi-system organ failure. Clin Toxicol (Phila). 2008 Nov; 46(9):834-7. PMID: 18608261.
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    80. Dunford JV, Lucas J, Vent N, Clark R, Cantrell FL. Asphyxiation due to dry ice in a walk-in freezer. J Emerg Med. 2009 May; 36(4):353-6. PMID: 18814998.
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    81. Matteucci MJ, Auten JD, Crowley B, Combs D, Clark R. Methamphetamine exposures in young children. Pediatr Emerg Care. 2007 Sep; 23(9):638-40. PMID: 17876253.
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    82. Schwarz KA, Cantrell FL, Vohra RB, Clark R. Suboxone (buprenorphine/naloxone) toxicity in pediatric patients: a case report. Pediatr Emerg Care. 2007 Sep; 23(9):651-2. PMID: 17876257.
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    83. Matteucci MJ, Hannum JE, Riffenburgh RH, Clark R. Pediatric sex group differences in location of snakebite injuries requiring antivenom therapy. J Med Toxicol. 2007 Sep; 3(3):103-6. PMID: 18072145; PMCID: PMC3550059.
    84. de Guzman GC, Khaleghi M, Riffenberg RH, Clark R. A survey of the use of foreign-purchased medications in a border community emergency department patient population. J Emerg Med. 2007 Aug; 33(2):213-21. PMID: 17692779.
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    85. Cook MD, Clark R. Creatinine elevation associated with nitromethane exposure: a marker of potential methanol toxicity. J Emerg Med. 2007 Oct; 33(3):249-53. PMID: 17976551.
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    86. Tong TC, Hernandez M, Richardson WH, Betten DP, Favata M, Riffenburgh RH, Clark R, Tanen DA. Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. Ann Emerg Med. 2007 Sep; 50(3):282-8. PMID: 17559970.
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    87. Richardson WH, Goto CS, Gutglass DJ, Williams SR, Clark R. Rattlesnake envenomation with neurotoxicity refractory to treatment with crotaline Fab antivenom. Clin Toxicol (Phila). 2007 Jun-Aug; 45(5):472-5. PMID: 17503249.
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    88. Lerner CG, Hajduk PJ, Wagner R, Wagenaar FL, Woodall C, Gu YG, Searle XB, Florjancic AS, Zhang T, Clark R, Cooper CS, Mack JC, Yu L, Cai M, Betz SF, Chovan LE, McCall JO, Black-Schaefer CL, Kakavas SJ, Schurdak ME, Comess KM, Walter KA, Edalji R, Dorwin SA, Smith RA, Hebert EJ, Harlan JE, Metzger RE, Merta PJ, Baranowski JL, Coen ML, Thornewell SJ, Shivakumar AG, Saiki AY, Soni N, Bui M, Balli DJ, Sanders WJ, Nilius AM, Holzman TF, Fesik SW, Beutel BA. From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activity of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae. Chem Biol Drug Des. 2007 Jun; 69(6):395-404. PMID: 17581233.
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    89. Cantrell FL, Clark R. Supratherapeutic doses of sulfonylureas in diabetic patients: how much is too much? Clin Toxicol (Phila). 2007 Jun-Aug; 45(5):482-4. PMID: 17503251.
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    90. Clark R, Girard RH, Rao D, Ly BT, Davis DP. Stingray envenomation: a retrospective review of clinical presentation and treatment in 119 cases. J Emerg Med. 2007 Jul; 33(1):33-7. PMID: 17630073.
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    91. Gu YG, Weitzberg M, Clark R, Xu X, Li Q, Lubbers NL, Yang Y, Beno DW, Widomski DL, Zhang T, Hansen TM, Keyes RF, Waring JF, Carroll SL, Wang X, Wang R, Healan-Greenberg CH, Blomme EA, Beutel BA, Sham HL, Camp HS. N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications. J Med Chem. 2007 Mar 08; 50(5):1078-82. PMID: 17298049.
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    92. Clark R, Zhang T, Wang X, Wang R, Zhang X, Camp HS, Beutel BA, Sham HL, Gu YG. Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents. Bioorg Med Chem Lett. 2007 Apr 01; 17(7):1961-5. PMID: 17267221.
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    93. Betten DP, Cantrell FL, Thomas SC, Williams SR, Clark R. A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2007 Sep; 50(3):272-9. PMID: 17210206.
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    94. Cook MD, Williams SR, Clark R. Phenytoin-potentiated hepatotoxicity following acetaminophen overdose? A closer look. Dig Dis Sci. 2007 Jan; 52(1):208-9. PMID: 17151811.
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    95. Fung F, Cantrell FL, Clark R. Neurotoxicity of mercury in dental amalgam. JAMA. 2006 Sep 27; 296(12):1462; author reply 1462-3. PMID: 17003391.
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    96. Clark R, Zhang T, Xin Z, Liu G, Wang Y, Hansen TM, Wang X, Wang R, Zhang X, Frevert EU, Camp HS, Beutel BA, Sham HL, Gu YG. Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity. Bioorg Med Chem Lett. 2006 Dec 01; 16(23):6078-81. PMID: 16973360.
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    97. Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark R. Antidote use in the critically ill poisoned patient. J Intensive Care Med. 2006 Sep-Oct; 21(5):255-77. PMID: 16946442.
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    98. Gu YG, Weitzberg M, Clark R, Xu X, Li Q, Zhang T, Hansen TM, Liu G, Xin Z, Wang X, Wang R, McNally T, Zinker BA, Frevert EU, Camp HS, Camp H, Beutel BA, Sham HL. Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors. J Med Chem. 2006 Jun 29; 49(13):3770-3. PMID: 16789734.
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    99. Vohra R, Clark R. Chlorine-related inhalation injury from a swimming pool disinfectant in a 9-year-old girl. Pediatr Emerg Care. 2006 Apr; 22(4):254-7. PMID: 16651917.
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    100. Richardson WH, Tanen DA, Tong TC, Betten DP, Carstairs SD, Williams SR, Cantrell FL, Clark R. North American coral snake antivenin for the neutralization of non-native elapid venoms in a murine model. Acad Emerg Med. 2006 Feb; 13(2):121-6. PMID: 16436788.
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    101. Betten DP, Richardson WH, Tong TC, Clark R. Massive honey bee envenomation-induced rhabdomyolysis in an adolescent. Pediatrics. 2006 Jan; 117(1):231-5. PMID: 16396886.
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    102. Stamper GF, Longenecker KL, Fry EH, Jakob CG, Florjancic AS, Gu YG, Anderson DD, Cooper CS, Zhang T, Clark R, Cia Y, Black-Schaefer CL, Owen McCall J, Lerner CG, Hajduk PJ, Beutel BA, Stoll VS. Structure-based optimization of MurF inhibitors. Chem Biol Drug Des. 2006 Jan; 67(1):58-65. PMID: 16492149.
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    103. Barry JD, Durkovich D, Cantrell L, Richardson W, Tong T, Offerman S, Clark R, Tanen DA, Williams S. Vasopressin treatment of verapamil toxicity in the porcine model. J Med Toxicol. 2005 Dec; 1(1):3-10. PMID: 18072096; PMCID: PMC3550012.
    104. Matteucci MJ, Clark R. GSH poisoning. J Emerg Med. 2005 Oct; 29(3):344-5. PMID: 16183460.
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    105. Cook MD, Clark R. Acetaminophen toxicity. Pediatr Emerg Care. 2005 Oct; 21(10):703-4. PMID: 16215480.
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    106. Richardson WH, Tanen DA, Tong TC, Betten DP, Carstairs SD, Williams SR, Cantrell FL, Clark R. Crotalidae polyvalent immune Fab (ovine) antivenom is effective in the neutralization of South American viperidae venoms in a murine model. Ann Emerg Med. 2005 Jun; 45(6):595-602. PMID: 15940091.
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    107. Matteucci MJ, Williams SR, Clark R. Response to Latrodectus-associated compartment syndrome. Ann Emerg Med. 2005 Jun; 45(6):679-80; author reply 680-1. PMID: 15940109.
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    108. Yong H, Gu YG, Clark R, Marron T, Ma Z, Soni N, Stone GG, Nilius AM, Marsh K, Djuric SW. Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. Bioorg Med Chem Lett. 2005 May 16; 15(10):2653-8. PMID: 15863336.
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    109. Richardson WH, Barry JD, Tong TC, Williams SR, Clark R. Rattlesnake envenomation to the face of an infant. Pediatr Emerg Care. 2005 Mar; 21(3):173-6. PMID: 15744196.
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    110. Cantrell FL, Clark R, Manoguerra AS. Determining triage guidelines for unintentional overdoses with calcium channel antagonists. Clin Toxicol (Phila). 2005; 43(7):849-53. PMID: 16440512.
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    111. Tanen DA, Danish DC, Grice GA, Riffenburgh RH, Clark R. Fasciotomy worsens the amount of myonecrosis in a porcine model of crotaline envenomation. Ann Emerg Med. 2004 Aug; 44(2):99-104. PMID: 15278079.
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    112. Clark R, Wang S, Ma Z, Weitzberg M, Motter C, Tufano M, Wagner R, Gu YG, Dandliker PJ, Lerner CG, Chovan LE, Cai Y, Black-Schaefer CL, Lynch L, Kalvin D, Nilius AM, Pratt SD, Soni N, Zhang T, Zhang X, Beutel BA. Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants. Bioorg Med Chem Lett. 2004 Jun 21; 14(12):3299-302. PMID: 15149694.
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    113. Saffran AJ, Clark R. Torus mandibularis: an unusual cause of obstructive sleep apnea. Ear Nose Throat J. 2004 May; 83(5):324. PMID: 15195878.
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    114. Ly BT, Schneir AB, Clark R. Effect of whole bowel irrigation on the pharmacokinetics of an acetaminophen formulation and progression of radiopaque markers through the gastrointestinal tract. Ann Emerg Med. 2004 Feb; 43(2):189-95. PMID: 14747807.
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    115. Gu YG, Florjancic AS, Clark R, Zhang T, Cooper CS, Anderson DD, Lerner CG, McCall JO, Cai Y, Black-Schaefer CL, Stamper GF, Hajduk PJ, Beutel BA. Structure-activity relationships of novel potent MurF inhibitors. Bioorg Med Chem Lett. 2004 Jan 05; 14(1):267-70. PMID: 14684340.
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    116. Fung F, Clark R. Health effects of mycotoxins: a toxicological overview. J Toxicol Clin Toxicol. 2004; 42(2):217-34. PMID: 15214629.
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    117. Clark R, Williams SR, Fung F, Schneir AB, Ly BT, Tanen DA, Munday SW. A reassessment of topical organic phosphorus insecticide exposures and permanent paralysis. J Toxicol Clin Toxicol. 2004; 42(7):991-2. PMID: 15641646.
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    118. Patel RJ, Saylor T, Williams SR, Clark R. Prevalence of autonomic signs and symptoms in antimuscarinic drug poisonings. J Emerg Med. 2004 Jan; 26(1):89-94. PMID: 14751484.
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    119. Dandliker PJ, Pratt SD, Nilius AM, Black-Schaefer C, Ruan X, Towne DL, Clark R, Englund EE, Wagner R, Weitzberg M, Chovan LE, Hickman RK, Daly MM, Kakavas S, Zhong P, Cao Z, David CA, Xuei X, Lerner CG, Soni NB, Bui M, Shen LL, Cai Y, Merta PJ, Saiki AY, Beutel BA. Novel antibacterial class. Antimicrob Agents Chemother. 2003 Dec; 47(12):3831-9. PMID: 14638491; PMCID: PMC296205.
    120. Schneir AB, Offerman SR, Ly BT, Davis JM, Baldwin RT, Williams SR, Clark R. Complications of diagnostic physostigmine administration to emergency department patients. Ann Emerg Med. 2003 Jul; 42(1):14-9. PMID: 12827117.
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    121. Richardson WH, Clark R, Gerard WC. Another hazard of college drinking: the black light concoction. Ann Emerg Med. 2003 Jun; 41(6):890-91. PMID: 12790127.
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    122. Offerman SR, Barry JD, Schneir A, Clark R. Biphasic rattlesnake venom-induced thrombocytopenia. J Emerg Med. 2003 Apr; 24(3):289-93. PMID: 12676300.
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    123. Tanen DA, Danish DC, Clark R. Crotalidae polyvalent immune Fab antivenom limits the decrease in perfusion pressure of the anterior leg compartment in a porcine crotaline envenomation model. Ann Emerg Med. 2003 Mar; 41(3):384-90. PMID: 12605206.
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    124. Munday SW, Williams SR, Clark R. Dendrotoxin poisoning in a neurobiochemist. J Toxicol Clin Toxicol. 2003; 41(2):163-5. PMID: 12733854.
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    125. Ingels M, Marks D, Clark R. A survey of medical toxicology training in psychiatry residency programs. Acad Psychiatry. 2003; 27(1):50-3. PMID: 12824122.
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    126. Offerman SR, Bush SP, Moynihan JA, Clark R. Crotaline Fab antivenom for the treatment of children with rattlesnake envenomation. Pediatrics. 2002 Nov; 110(5):968-71. PMID: 12415038.
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    127. Schneir AB, Vadeboncoeur TF, Offerman SR, Barry JD, Ly BT, Williams SR, Clark R. Massive OxyContin ingestion refractory to naloxone therapy. Ann Emerg Med. 2002 Oct; 40(4):425-8. PMID: 12239500.
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    128. Schneir AB, Clark R. Coin rubbing and camphor intoxication. JAMA. 2002 Sep 25; 288(12):1471; author reply 1471. PMID: 12243631.
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    129. Ingels M, Lai C, Tai W, Manning BH, Rangan C, Williams SR, Manoguerra AS, Albertson T, Clark R. A prospective study of acute, unintentional, pediatric superwarfarin ingestions managed without decontamination. Ann Emerg Med. 2002 Jul; 40(1):73-8. PMID: 12085076.
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    130. Clark R, McKinney PE, Chase PB, Walter FG. Immediate and delayed allergic reactions to Crotalidae polyvalent immune Fab (ovine) antivenom. Ann Emerg Med. 2002 Jun; 39(6):671-6. PMID: 12023714.
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    131. Ingels M, Beauchamp J, Clark R, Williams SR. Delayed valproic acid toxicity: a retrospective case series. Ann Emerg Med. 2002 Jun; 39(6):616-21. PMID: 12023704.
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    132. Nordt SP, Williams SR, Clark R. Pharmacologic misadventure resulting in hypercalcemia from vitamin D intoxication. J Emerg Med. 2002 Apr; 22(3):302-3. PMID: 11932103.
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    133. Ly BT, Williams SR, Clark R. Mercuric oxide poisoning treated with whole-bowel irrigation and chelation therapy. Ann Emerg Med. 2002 Mar; 39(3):312-5. PMID: 11867987.
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    134. Chan TC, Vilke GM, Clausen J, Clark R, Schmidt P, Snowden T, Neuman T. The effect of oleoresin capsicum "pepper" spray inhalation on respiratory function. J Forensic Sci. 2002 Mar; 47(2):299-304. PMID: 11908598.
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    135. Deitch S, Williams SR, Clark R. Blebs associated with rattlesnake envenomation followed by serum sickness. J Emerg Med. 2002 Feb; 22(2):207-8. PMID: 11858930.
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    136. Clark R, Phillips M, Manoguerra AS, Chan TC. Evaluating the utilization of a regional poison center by Latino communities. J Toxicol Clin Toxicol. 2002; 40(7):855-60. PMID: 12507054.
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    137. Clark R. The safety and efficacy of antivenin Latrodectus mactans. J Toxicol Clin Toxicol. 2001; 39(2):125-7. PMID: 11407497.
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    138. Tunget CL, Clark R. Invasion of the 'killer' bees. Postgrad Med. 1993 Aug; 94(2):92-102. PMID: 29206617.
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