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Samara Reck-Peterson

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0694
La Jolla CA 92093
Phone858-246-1265
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    Collapse Research 
    Collapse Research Activities and Funding
    Cellular control of microtubule-based transport.
    NIH/NIGMS R01GM121772Feb 1, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Regulation of Cytoplasmic Dynein
    NIH/NIGMS R01GM107214Jun 10, 2014 - Feb 28, 2018
    Role: Principal Investigator
    Dissecting dynein motor function using DNA nanotechnology
    NIH/NIGMS R01GM100947Jan 1, 2013 - Nov 30, 2016
    Role: Principal Investigator
    Cellular Control of Microtubule-Based Transport: Unraveling its Molecular Mechan
    NIH DP2OD004268Sep 30, 2008 - Aug 31, 2013
    Role: Principal Investigator
    Molecular Dissection of Cytoplasmic Dynein
    NIH/NIGMS F32GM067403Feb 1, 2003 - Jul 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Reck-Peterson SL, Redwine WB, Vale RD, Carter AP. Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes. Nat Rev Mol Cell Biol. 2018 May 08. PMID: 29740130.
      View in: PubMed
    2. Reck-Peterson SL, Redwine WB, Vale RD, Carter AP. The cytoplasmic dynein transport machinery and its many cargoes. Nat Rev Mol Cell Biol. 2018 Apr 16. PMID: 29662141.
      View in: PubMed
    3. DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Sep 07; 170(6):1197-1208.e12. PMID: 28886386.
      View in: PubMed
    4. Redwine WB, DeSantis ME, Hollyer I, Htet ZM, Tran PT, Swanson SK, Florens L, Washburn MP, Reck-Peterson SL. The human cytoplasmic dynein interactome reveals novel activators of motility. Elife. 2017 07 18; 6. PMID: 28718761.
      View in: PubMed
    5. Lippert LG, Dadosh T, Hadden JA, Karnawat V, Diroll BT, Murray CB, Holzbaur ELF, Schulten K, Reck-Peterson SL, Goldman YE. Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):E4564-E4573. PMID: 28533393.
      View in: PubMed
    6. Salogiannis J, Reck-Peterson SL. Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport. Trends Cell Biol. 2017 02; 27(2):141-150. PMID: 27665063.
      View in: PubMed
    7. Salogiannis J, Egan MJ, Reck-Peterson SL. Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA. J Cell Biol. 2016 Feb 01; 212(3):289-96. PMID: 26811422; PMCID: PMC4748578.
    8. Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. Mechanism and regulation of cytoplasmic dynein. Annu Rev Cell Dev Biol. 2015; 31:83-108. PMID: 26436706; PMCID: PMC4644480 [Available on 11/13/16].
    9. Reck-Peterson SL. Dynactin revealed. Nat Struct Mol Biol. 2015 May; 22(5):359-60. PMID: 25945887.
      View in: PubMed
    10. Egan MJ, McClintock MA, Hollyer IH, Elliott HL, Reck-Peterson SL. Cytoplasmic dynein is required for the spatial organization of protein aggregates in filamentous fungi. Cell Rep. 2015 Apr 14; 11(2):201-9. PMID: 25865884; PMCID: PMC4465048.
    11. Toropova K, Zou S, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner AE. Lis1 regulates dynein by sterically blocking its mechanochemical cycle. Elife. 2014 Nov 07; 3. PMID: 25380312; PMCID: PMC4359366.
    12. Downes DJ, Chonofsky M, Tan K, Pfannenstiel BT, Reck-Peterson SL, Todd RB. Characterization of the mutagenic spectrum of 4-nitroquinoline 1-oxide (4-NQO) in Aspergillus nidulans by whole genome sequencing. G3 (Bethesda). 2014 Oct 27; 4(12):2483-92. PMID: 25352541; PMCID: PMC4267943.
    13. Reck-Peterson SL. Molecular motors: Shifting gears with light. Nat Nanotechnol. 2014 Sep; 9(9):661-2. PMID: 25182035.
      View in: PubMed
    14. Roberts AJ, Goodman BS, Reck-Peterson SL. Reconstitution of dynein transport to the microtubule plus end by kinesin. Elife. 2014 Jun 10; 3:e02641. PMID: 24916158; PMCID: PMC4046564.
    15. Cheng L, Desai J, Miranda CJ, Duncan JS, Qiu W, Nugent AA, Kolpak AL, Wu CC, Drokhlyansky E, Delisle MM, Chan WM, Wei Y, Propst F, Reck-Peterson SL, Fritzsch B, Engle EC. Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling. Neuron. 2014 Apr 16; 82(2):334-49. PMID: 24656932; PMCID: PMC4002761.
    16. Tan K, Roberts AJ, Chonofsky M, Egan MJ, Reck-Peterson SL. A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity. Mol Biol Cell. 2014 Mar; 25(5):669-78. PMID: 24403603; PMCID: PMC3937092.
    17. Goodman BS, Reck-Peterson SL. Engineering defined motor ensembles with DNA origami. Methods Enzymol. 2014; 540:169-88. PMID: 24630107.
      View in: PubMed
    18. Reck-Peterson SL. Teaming up: from motors to people. Mol Biol Cell. 2013 Nov; 24(21):3267-9. PMID: 24174457; PMCID: PMC3814138.
    19. Reck-Peterson S. Samara Reck-Peterson: dynein defies expectations. Interview by Caitlin Sedwick. J Cell Biol. 2013 Jan 21; 200(2):128-9. PMID: 23337114; PMCID: PMC3549966.
    20. Egan MJ, McClintock MA, Reck-Peterson SL. Microtubule-based transport in filamentous fungi. Curr Opin Microbiol. 2012 Dec; 15(6):637-45. PMID: 23127389; PMCID: PMC3518651.
    21. Derr ND, Goodman BS, Jungmann R, Leschziner AE, Shih WM, Reck-Peterson SL. Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science. 2012 Nov 02; 338(6107):662-5. PMID: 23065903; PMCID: PMC3840815.
    22. Goodman BS, Derr ND, Reck-Peterson SL. Engineered, harnessed, and hijacked: synthetic uses for cytoskeletal systems. Trends Cell Biol. 2012 Dec; 22(12):644-52. PMID: 23059001; PMCID: PMC3505249.
    23. Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE. Structural basis for microtubule binding and release by dynein. Science. 2012 Sep 21; 337(6101):1532-1536. PMID: 22997337; PMCID: PMC3919166.
    24. Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL. Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 2012 Aug 31; 150(5):975-86. PMID: 22939623; PMCID: PMC3438448.
    25. Egan MJ, Tan K, Reck-Peterson SL. Lis1 is an initiation factor for dynein-driven organelle transport. J Cell Biol. 2012 Jun 25; 197(7):971-82. PMID: 22711696; PMCID: PMC3384415.
    26. Laan L, Pavin N, Husson J, Romet-Lemonne G, van Duijn M, López MP, Vale RD, Jülicher F, Reck-Peterson SL, Dogterom M. Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters. Cell. 2012 Feb 03; 148(3):502-14. PMID: 22304918; PMCID: PMC3292199.
    27. Qiu W, Derr ND, Goodman BS, Villa E, Wu D, Shih W, Reck-Peterson SL. Dynein achieves processive motion using both stochastic and coordinated stepping. Nat Struct Mol Biol. 2012 Jan 08; 19(2):193-200. PMID: 22231401; PMCID: PMC3272163.
    28. Zhang J, Tan K, Wu X, Chen G, Sun J, Reck-Peterson SL, Hammer JA, Xiang X. Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transport. PLoS One. 2011; 6(12):e28575. PMID: 22194856; PMCID: PMC3237463.
    29. Su X, Qiu W, Gupta ML, Pereira-Leal JB, Reck-Peterson SL, Pellman D. Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8. Mol Cell. 2011 Sep 02; 43(5):751-63. PMID: 21884976; PMCID: PMC3181003.
    30. Gennerich A, Reck-Peterson SL. Probing the force generation and stepping behavior of cytoplasmic Dynein. Methods Mol Biol. 2011; 783:63-80. PMID: 21909883.
      View in: PubMed
    31. Reck-Peterson SL, Derr ND, Stuurman N. Imaging single molecular motor motility with total internal reflection fluorescence microscopy (TIRFM). Cold Spring Harb Protoc. 2010 Mar; 2010(3):pdb.prot5399. PMID: 20194468.
      View in: PubMed
    32. Reck-Peterson SL, Derr ND, Stuurman N. Imaging single molecules using total internal reflection fluorescence microscopy (TIRFM). Cold Spring Harb Protoc. 2010 Mar; 2010(3):pdb.top73. PMID: 20194477.
      View in: PubMed
    33. Reck-Peterson SL, Derr ND, Stuurman N. Determining single-molecule intensity as a function of power density. Cold Spring Harb Protoc. 2010 Mar; 2010(3):pdb.prot5398. PMID: 20194467.
      View in: PubMed
    34. Kardon JR, Reck-Peterson SL, Vale RD. Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5669-74. PMID: 19293377; PMCID: PMC2657088.
    35. Cho C, Reck-Peterson SL, Vale RD. Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J Biol Chem. 2008 Sep 19; 283(38):25839-45. PMID: 18650442; PMCID: PMC2533788.
    36. Chang W, Zaarour RF, Reck-Peterson S, Rinn J, Singer RH, Snyder M, Novick P, Mooseker MS. Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body. RNA. 2008 Mar; 14(3):491-502. PMID: 18218704; PMCID: PMC2248268.
    37. Gennerich A, Carter AP, Reck-Peterson SL, Vale RD. Force-induced bidirectional stepping of cytoplasmic dynein. Cell. 2007 Nov 30; 131(5):952-65. PMID: 18045537; PMCID: PMC2851641.
    38. Reck-Peterson SL, Yildiz A, Carter AP, Gennerich A, Zhang N, Vale RD. Single-molecule analysis of dynein processivity and stepping behavior. Cell. 2006 Jul 28; 126(2):335-48. PMID: 16873064; PMCID: PMC2851639.
    39. Shih JL, Reck-Peterson SL, Newitt R, Mooseker MS, Aebersold R, Herskowitz I. Cell polarity protein Spa2P associates with proteins involved in actin function in Saccharomyces cerevisiae. Mol Biol Cell. 2005 Oct; 16(10):4595-608. PMID: 16030260; PMCID: PMC1237067.
    40. Gibbons IR, Garbarino JE, Tan CE, Reck-Peterson SL, Vale RD, Carter AP. The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. J Biol Chem. 2005 Jun 24; 280(25):23960-5. PMID: 15826937; PMCID: PMC1464088.
    41. Reck-Peterson SL, Vale RD. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14305. PMID: 15693149; PMCID: PMC521152.
    42. Reck-Peterson SL, Vale RD. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1491-5. PMID: 14755060; PMCID: PMC341754.
    43. Olave IA, Reck-Peterson SL, Crabtree GR. Nuclear actin and actin-related proteins in chromatin remodeling. Annu Rev Biochem. 2002; 71:755-81. PMID: 12045110.
      View in: PubMed
    44. Reck-Peterson SL, Tyska MJ, Novick PJ, Mooseker MS. The yeast class V myosins, Myo2p and Myo4p, are nonprocessive actin-based motors. J Cell Biol. 2001 May 28; 153(5):1121-6. PMID: 11381095; PMCID: PMC2174330.
    45. Karpova TS, Reck-Peterson SL, Elkind NB, Mooseker MS, Novick PJ, Cooper JA. Role of actin and Myo2p in polarized secretion and growth of Saccharomyces cerevisiae. Mol Biol Cell. 2000 May; 11(5):1727-37. PMID: 10793147; PMCID: PMC14879.
    46. Reck-Peterson SL, Provance DW, Mooseker MS, Mercer JA. Class V myosins. Biochim Biophys Acta. 2000 Mar 17; 1496(1):36-51. PMID: 10722875.
      View in: PubMed
    47. Reck-Peterson SL, Novick PJ, Mooseker MS. The tail of a yeast class V myosin, myo2p, functions as a localization domain. Mol Biol Cell. 1999 Apr; 10(4):1001-17. PMID: 10198053; PMCID: PMC25227.