Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Shunichi Shimasaki

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentReproductive Medicine
    Address9500 Gilman Drive #0633
    CA La Jolla 92093
    Phone858-822-1414
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      A Novel Function of the Oocyte in Estrogen-Regulated FSH Action
      NIH/NICHD R21HD060032Aug 1, 2008 - Jul 31, 2011
      Role: Principal Investigator
      Molecular Basis of BMP-15 Function
      NIH/NICHD R01HD041494May 1, 2002 - Aug 31, 2014
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Yamada-Nomoto K, Yoshino O, Akiyama I, Iwase A, Ono Y, Nakamura T, Harada M, Nakashima A, Shima T, Ushijima A, Osuga Y, Chang RJ, Shimasaki S, Saito S. PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-ß and TNF-a in mononuclear cells by insulin-sensitizing drugs. Am J Reprod Immunol. 2017 Jul; 78(1). PMID: 28337819.
        View in: PubMed
      2. Cook-Andersen H, Curnow KJ, Su HI, Chang RJ, Shimasaki S. Growth and differentiation factor 9 promotes oocyte growth at the primary but not the early secondary stage in three-dimensional follicle culture. J Assist Reprod Genet. 2016 Aug; 33(8):1067-77. PMID: 27155601.
        View in: PubMed
      3. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175.
        View in: PubMed
      4. Shayya RF, Rosencrantz MA, Chuan SS, Cook-Andersen H, Roudebush WE, Irene Su H, Shimasaki S, Chang RJ. Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome. Fertil Steril. 2014 Jan; 101(1):275-9. PMID: 24188875.
        View in: PubMed
      5. Hoang YD, McTavish KJ, Chang RJ, Shimasaki S. Paracrine regulation of theca androgen production by granulosa cells in the ovary. Fertil Steril. 2013 Aug; 100(2):561-7. PMID: 23706336.
        View in: PubMed
      6. Miyoshi T, Otsuka F, Shimasaki S. GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells. Biochem Biophys Res Commun. 2013 May 3; 434(2):401-6. PMID: 23583200.
        View in: PubMed
      7. McTavish KJ, Nonis D, Hoang YD, Shimasaki S. Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells. Mol Cell Endocrinol. 2013 Jun 15; 372(1-2):57-64. PMID: 23567549.
        View in: PubMed
      8. Nonis D, McTavish KJ, Shimasaki S. Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434. Mol Cell Endocrinol. 2013 Jun 15; 372(1-2):42-8. PMID: 23523567.
        View in: PubMed
      9. Hashimoto O, Takagi R, Yanuma F, Doi S, Shindo J, Endo H, Hasegawa Y, Shimasaki S. Identification and characterization of canine growth differentiation factor-9 and its splicing variant. Gene. 2012 May 15; 499(2):266-72. PMID: 22446043.
        View in: PubMed
      10. Otsuka F, McTavish KJ, Shimasaki S. Integral role of GDF-9 and BMP-15 in ovarian function. Mol Reprod Dev. 2011 Jan; 78(1):9-21. PMID: 21226076.
        View in: PubMed
      11. Inagaki K, Shimasaki S. Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins WITH mutations in the proregion. Mol Cell Endocrinol. 2010 Oct 26; 328(1-2):1-7. PMID: 20547206.
        View in: PubMed
      12. Tibaldi E, Arrigoni G, Martinez HM, Inagaki K, Shimasaki S, Pinna LA. Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9. FEBS Lett. 2010 Feb 19; 584(4):801-5. PMID: 20067794.
        View in: PubMed
      13. McMahon HE, Hashimoto O, Mellon PL, Shimasaki S. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology. 2008 Jun; 149(6):2807-15. PMID: 18308851.
        View in: PubMed
      14. Wachs DS, Coffler MS, Malcom PJ, Shimasaki S, Chang RJ. Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008 May; 93(5):1827-33. PMID: 18285408.
        View in: PubMed
      15. Saito S, Yano K, Sharma S, McMahon HE, Shimasaki S. Characterization of the post-translational modification of recombinant human BMP-15 mature protein. Protein Sci. 2008 Feb; 17(2):362-70. PMID: 18227435.
        View in: PubMed
      16. McMahon HE, Sharma S, Shimasaki S. Phosphorylation of bone morphogenetic protein-15 and growth and differentiation factor-9 plays a critical role in determining agonistic or antagonistic functions. Endocrinology. 2008 Feb; 149(2):812-7. PMID: 18006624.
        View in: PubMed
      17. Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, O'Brien MJ, Matzuk MM, Shimasaki S, Eppig JJ. Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. Development. 2007 Jul; 134(14):2593-603. PMID: 17553902.
        View in: PubMed
      18. Yoshino O, McMahon HE, Sharma S, Shimasaki S. A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10678-83. PMID: 16818886.
        View in: PubMed
      19. Clelland E, Kohli G, Campbell RK, Sharma S, Shimasaki S, Peng C. Bone morphogenetic protein-15 in the zebrafish ovary: complementary deoxyribonucleic acid cloning, genomic organization, tissue distribution, and role in oocyte maturation. Endocrinology. 2006 Jan; 147(1):201-9. PMID: 16210364.
        View in: PubMed
      20. Otsuka F, Moore RK, Wang X, Sharma S, Miyoshi T, Shimasaki S. Essential role of the oocyte in estrogen amplification of follicle-stimulating hormone signaling in granulosa cells. Endocrinology. 2005 Aug; 146(8):3362-7. PMID: 15878960.
        View in: PubMed
      21. Moore RK, Shimasaki S. Molecular biology and physiological role of the oocyte factor, BMP-15. Mol Cell Endocrinol. 2005 Apr 29; 234(1-2):67-73. PMID: 15836954.
        View in: PubMed
      22. Hashimoto O, Moore RK, Shimasaki S. Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5426-31. PMID: 15809424.
        View in: PubMed
      23. Thomas FH, Ethier JF, Shimasaki S, Vanderhyden BC. Follicle-stimulating hormone regulates oocyte growth by modulation of expression of oocyte and granulosa cell factors. Endocrinology. 2005 Feb; 146(2):941-9. PMID: 15539559.
        View in: PubMed
      24. Lee WS, Yoon SJ, Yoon TK, Cha KY, Lee SH, Shimasaki S, Lee S, Lee KA. Effects of bone morphogenetic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary. Mol Reprod Dev. 2004 Oct; 69(2):159-63. PMID: 15293217.
        View in: PubMed
      25. Moore RK, Erickson GF, Shimasaki S. Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals? Trends Endocrinol Metab. 2004 Oct; 15(8):356-61. PMID: 15380806.
        View in: PubMed
      26. Matsui M, Sonntag B, Hwang SS, Byerly T, Hourvitz A, Adashi EY, Shimasaki S, Erickson GF. Pregnancy-associated plasma protein-a production in rat granulosa cells: stimulation by follicle-stimulating hormone and inhibition by the oocyte-derived bone morphogenetic protein-15. Endocrinology. 2004 Aug; 145(8):3686-95. PMID: 15087430.
        View in: PubMed
      27. Liao WX, Moore RK, Shimasaki S. Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9. J Biol Chem. 2004 Apr 23; 279(17):17391-6. PMID: 14970198.
        View in: PubMed
      28. Shimasaki S, Moore RK, Otsuka F, Erickson GF. The bone morphogenetic protein system in mammalian reproduction. Endocr Rev. 2004 Feb; 25(1):72-101. PMID: 14769828.
        View in: PubMed
      29. Erickson GF, Shimasaki S. The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Reprod Biol Endocrinol. 2003 Feb 5; 1:9. PMID: 12741959.
        View in: PubMed
      30. Shimasaki S, Moore RK, Erickson GF, Otsuka F. The role of bone morphogenetic proteins in ovarian function. Reprod Suppl. 2003; 61:323-37. PMID: 14635945.
        View in: PubMed
      31. Otsuka F, Shimasaki S. A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes. Endocrinology. 2002 Dec; 143(12):4938-41. PMID: 12446622.
        View in: PubMed
      32. Liao WX, Moore RK, Otsuka F, Shimasaki S. Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep. J Biol Chem. 2003 Feb 7; 278(6):3713-9. PMID: 12446716.
        View in: PubMed
      33. Moore RK, Otsuka F, Shimasaki S. Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. J Biol Chem. 2003 Jan 3; 278(1):304-10. PMID: 12419820.
        View in: PubMed
      34. Otsuka F, Shimasaki S. A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8060-5. PMID: 12048244.
        View in: PubMed
      35. Teixeira Filho FL, Baracat EC, Lee TH, Suh CS, Matsui M, Chang RJ, Shimasaki S, Erickson GF. Aberrant expression of growth differentiation factor-9 in oocytes of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Mar; 87(3):1337-44. PMID: 11889206.
        View in: PubMed
      36. Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF. A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7282-7. PMID: 10377406.
        View in: PubMed