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    Deborah Yelon

    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0380
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Modulating Morphogenesis: Genetic Regulation of Cardiac Cell Movement in Zebrafish
      NIH/NHLBI R01HL133166Aug 15, 2016 - Jun 30, 2020
      Role: Principal Investigator
      Genetic Regulation of Outflow Tract Formation in Zebrafish
      NIH/NHLBI R01HL108599Apr 1, 2011 - Mar 31, 2020
      Role: Principal Investigator
      Regulation of cardiac chamber morphogenesis in zebrafish
      NIH/NHLBI R01HL081911Jul 1, 2005 - May 31, 2010
      Role: Principal Investigator
      Comparative genetics of cardiac chamber formation
      NIH/NICHD R21HD047858Dec 5, 2004 - Nov 30, 2007
      Role: Principal Investigator
      Genetic Regulation of Cardiac Patterning in Zebrafish
      NIH/NHLBI R01HL069594Jul 1, 2002 - Jan 31, 2016
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Pradhan A, Zeng XI, Sidhwani P, Marques SR, George V, Targoff KL, Chi NC, Yelon D. FGF signaling enforces cardiac chamber identity in the developing ventricle. Development. 2017 Apr 01; 144(7):1328-1338. PMID: 28232600.
        View in: PubMed
      2. Bloomekatz J, Singh R, Prall OW, Dunn AC, Vaughan M, Loo CS, Harvey RP, Yelon D. Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. Elife. 2017 Jan 18; 6. PMID: 28098558.
        View in: PubMed
      3. Perens EA, Garavito-Aguilar ZV, Guio-Vega GP, Peña KT, Schindler YL, Yelon D. Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm. Elife. 2016 Nov 02; 5. PMID: 27805568.
        View in: PubMed
      4. Ryckebüsch L, Hernandez L, Wang C, Phan J, Yelon D. Tmem2 regulates cell-matrix interactions that are essential for muscle fiber attachment. Development. 2016 Aug 15; 143(16):2965-72. PMID: 27471259; PMCID: PMC5004884 [Available on 08/15/17].
      5. Houk AR, Yelon D. Strategies for analyzing cardiac phenotypes in the zebrafish embryo. Methods Cell Biol. 2016; 134:335-68. PMID: 27312497.
        View in: PubMed
      6. Andrew DJ, Yelon D. Editorial overview: Developmental mechanisms, patterning and organogenesis. Curr Opin Genet Dev. 2015 Jun; 32:v-viii. PMID: 26051229; PMCID: PMC4750389.
      7. Schindler YL, Garske KM, Wang J, Firulli BA, Firulli AB, Poss KD, Yelon D. Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. Development. 2014 Aug; 141(16):3112-22. PMID: 25038045; PMCID: PMC4197543.
      8. Zeng XX, Yelon D. Cadm4 restricts the production of cardiac outflow tract progenitor cells. Cell Rep. 2014 May 22; 7(4):951-60. PMID: 24813897; PMCID: PMC4147860.
      9. Schumacher JA, Bloomekatz J, Garavito-Aguilar ZV, Yelon D. tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. Dev Biol. 2013 Nov 15; 383(2):214-26. PMID: 24075907; PMCID: PMC3932745.
      10. Targoff KL, Colombo S, George V, Schell T, Kim SH, Solnica-Krezel L, Yelon D. Nkx genes are essential for maintenance of ventricular identity. Development. 2013 Oct; 140(20):4203-13. PMID: 24026123; PMCID: PMC3787760.
      11. Miura GI, Yelon D. Cardiovascular biology: play it again, Gata4. Curr Biol. 2013 Jul 22; 23(14):R619-21. PMID: 23885880.
        View in: PubMed
      12. Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 2013 Jun 27; 498(7455):497-501. PMID: 23783515; PMCID: PMC4090927.
      13. Giurumescu CA, Kang S, Planchon TA, Betzig E, Bloomekatz J, Yelon D, Cosman P, Chisholm AD. Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos. Development. 2012 Nov; 139(22):4271-9. PMID: 23052905; PMCID: PMC3478691.
      14. Yelon D. Developmental biology: Heart under construction. Nature. 2012 Apr 25; 484(7395):459-60. PMID: 22538602.
        View in: PubMed
      15. Lin YF, Swinburne I, Yelon D. Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart. Dev Biol. 2012 Feb 15; 362(2):242-53. PMID: 22192888; PMCID: PMC3279915.
      16. Totong R, Schell T, Lescroart F, Ryckebüsch L, Lin YF, Zygmunt T, Herwig L, Krudewig A, Gershoony D, Belting HG, Affolter M, Torres-Vázquez J, Yelon D. The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development. 2011 Oct; 138(19):4199-205. PMID: 21896630; PMCID: PMC3171221.
      17. Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, Macrae CA, Poss KD. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development. 2011 Aug; 138(16):3421-30. PMID: 21752928; PMCID: PMC3143562.
      18. Waxman JS, Yelon D. Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Dev Biol. 2011 Apr 01; 352(1):128-40. PMID: 21276787; PMCID: PMC3207040.
      19. Peshkovsky C, Totong R, Yelon D. Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish. Dev Dyn. 2011 Feb; 240(2):446-56. PMID: 21246662.
        View in: PubMed
      20. Miura GI, Yelon D. A guide to analysis of cardiac phenotypes in the zebrafish embryo. Methods Cell Biol. 2011; 101:161-80. PMID: 21550443; PMCID: PMC3292854.
      21. Evans SM, Yelon D, Conlon FL, Kirby ML. Myocardial lineage development. Circ Res. 2010 Dec 10; 107(12):1428-44. PMID: 21148449; PMCID: PMC3073310.
      22. Sogah VM, Serluca FC, Fishman MC, Yelon D, Macrae CA, Mably JD. Distinct troponin C isoform requirements in cardiac and skeletal muscle. Dev Dyn. 2010 Nov; 239(11):3115-23. PMID: 20925115; PMCID: PMC2965274.
      23. Garavito-Aguilar ZV, Riley HE, Yelon D. Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development. 2010 Oct; 137(19):3215-20. PMID: 20724450; PMCID: PMC2934734.
      24. Mandel EM, Kaltenbrun E, Callis TE, Zeng XX, Marques SR, Yelon D, Wang DZ, Conlon FL. The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development. 2010 Jun; 137(11):1919-29. PMID: 20460370; PMCID: PMC2867324.
      25. Feng L, Hernandez RE, Waxman JS, Yelon D, Moens CB. Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Dev Biol. 2010 Feb 01; 338(1):1-14. PMID: 19874812; PMCID: PMC2858591.
      26. Waxman JS, Yelon D. Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling. Dev Dyn. 2009 May; 238(5):1207-13. PMID: 19384962; PMCID: PMC2739864.
      27. de Pater E, Clijsters L, Marques SR, Lin YF, Garavito-Aguilar ZV, Yelon D, Bakkers J. Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development. 2009 May; 136(10):1633-41. PMID: 19395641; PMCID: PMC2673760.
      28. Marques SR, Yelon D. Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Dev Biol. 2009 Apr 15; 328(2):472-82. PMID: 19232521; PMCID: PMC2709526.
      29. Mich JK, Blaser H, Thomas NA, Firestone AJ, Yelon D, Raz E, Chen JK. Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Dev Biol. 2009 Apr 15; 328(2):342-54. PMID: 19389352; PMCID: PMC2674121.
      30. Osborne N, Brand-Arzamendi K, Ober EA, Jin SW, Verkade H, Holtzman NG, Yelon D, Stainier DY. The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Curr Biol. 2008 Dec 09; 18(23):1882-8. PMID: 19062281; PMCID: PMC2741689.
      31. Waxman JS, Keegan BR, Roberts RW, Poss KD, Yelon D. Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. Dev Cell. 2008 Dec; 15(6):923-34. PMID: 19081079; PMCID: PMC2752051.
      32. de Campos-Baptista MI, Holtzman NG, Yelon D, Schier AF. Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish. Dev Dyn. 2008 Dec; 237(12):3624-33. PMID: 18985714; PMCID: PMC2632806.
      33. Thomas NA, Koudijs M, van Eeden FJ, Joyner AL, Yelon D. Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. Development. 2008 Nov; 135(22):3789-99. PMID: 18842815; PMCID: PMC4213142.
      34. Linville A, Radtke K, Waxman JS, Yelon D, Schilling TF. Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches. Dev Biol. 2009 Jan 01; 325(1):60-70. PMID: 18929555; PMCID: PMC3045866.
      35. Targoff KL, Schell T, Yelon D. Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number. Dev Biol. 2008 Oct 15; 322(2):314-21. PMID: 18718462; PMCID: PMC2752039.
      36. Marques SR, Lee Y, Poss KD, Yelon D. Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart. Dev Biol. 2008 Sep 15; 321(2):397-406. PMID: 18639539; PMCID: PMC2752040.
      37. Schoenebeck JJ, Keegan BR, Yelon D. Vessel and blood specification override cardiac potential in anterior mesoderm. Dev Cell. 2007 Aug; 13(2):254-67. PMID: 17681136; PMCID: PMC2709538.
      38. Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, Rohr KB. Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development. 2007 Aug; 134(15):2871-9. PMID: 17611226.
        View in: PubMed
      39. Holtzman NG, Schoenebeck JJ, Tsai HJ, Yelon D. Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Development. 2007 Jun; 134(12):2379-86. PMID: 17537802.
        View in: PubMed
      40. Auman HJ, Coleman H, Riley HE, Olale F, Tsai HJ, Yelon D. Functional modulation of cardiac form through regionally confined cell shape changes. PLoS Biol. 2007 Mar; 5(3):e53. PMID: 17311471; PMCID: PMC1802756.
      41. Waxman JS, Yelon D. Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors. Dev Dyn. 2007 Feb; 236(2):587-95. PMID: 17195188.
        View in: PubMed
      42. Schoenebeck JJ, Yelon D. Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics. Semin Cell Dev Biol. 2007 Feb; 18(1):27-35. PMID: 17241801; PMCID: PMC1876688.
      43. Ebert AM, Hume GL, Warren KS, Cook NP, Burns CG, Mohideen MA, Siegal G, Yelon D, Fishman MC, Garrity DM. Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17705-10. PMID: 16314582; PMCID: PMC1308882.
      44. Trinh LA, Yelon D, Stainier DY. Hand2 regulates epithelial formation during myocardial diferentiation. Curr Biol. 2005 Mar 08; 15(5):441-6. PMID: 15786591.
        View in: PubMed
      45. Keegan BR, Feldman JL, Begemann G, Ingham PW, Yelon D. Retinoic acid signaling restricts the cardiac progenitor pool. Science. 2005 Jan 14; 307(5707):247-9. PMID: 15653502.
        View in: PubMed
      46. Keegan BR, Meyer D, Yelon D. Organization of cardiac chamber progenitors in the zebrafish blastula. Development. 2004 Jul; 131(13):3081-91. PMID: 15175246.
        View in: PubMed
      47. Glickman NS, Yelon D. Coordinating morphogenesis: epithelial integrity during heart tube assembly. Dev Cell. 2004 Mar; 6(3):311-2. PMID: 15030750.
        View in: PubMed
      48. Auman HJ, Yelon D. Vertebrate organogenesis: getting the heart into shape. Curr Biol. 2004 Feb 17; 14(4):R152-3. PMID: 15027466.
        View in: PubMed
      49. O'Brien EK, d'Alençon C, Bonde G, Li W, Schoenebeck J, Allende ML, Gelb BD, Yelon D, Eisen JS, Cornell RA. Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Dev Biol. 2004 Jan 01; 265(1):246-61. PMID: 14697367.
        View in: PubMed
      50. Berdougo E, Coleman H, Lee DH, Stainier DY, Yelon D. Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development. 2003 Dec; 130(24):6121-9. PMID: 14573521.
        View in: PubMed
      51. Miller CT, Yelon D, Stainier DY, Kimmel CB. Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development. 2003 Apr; 130(7):1353-65. PMID: 12588851.
        View in: PubMed
      52. Glickman NS, Yelon D. Cardiac development in zebrafish: coordination of form and function. Semin Cell Dev Biol. 2002 Dec; 13(6):507-13. PMID: 12468254.
        View in: PubMed
      53. Yelon D, Stainier DY. Pattern formation: swimming in retinoic acid. Curr Biol. 2002 Oct 15; 12(20):R707-9. PMID: 12401191.
        View in: PubMed
      54. Keegan BR, Feldman JL, Lee DH, Koos DS, Ho RK, Stainier DY, Yelon D. The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development. 2002 Apr; 129(7):1623-32. PMID: 11923199.
        View in: PubMed
      55. Yelon D, Weinstein BM, Fishman MC. Cardiovascular system. Results Probl Cell Differ. 2002; 40:298-321. PMID: 12353483.
        View in: PubMed
      56. Yelon D, Feldman JL, Keegan BR. Genetic regulation of cardiac patterning in zebrafish. Cold Spring Harb Symp Quant Biol. 2002; 67:19-25. PMID: 12858519.
        View in: PubMed
      57. Yelon D. Cardiac patterning and morphogenesis in zebrafish. Dev Dyn. 2001 Dec; 222(4):552-63. PMID: 11748825.
        View in: PubMed
      58. Kikuchi Y, Agathon A, Alexander J, Thisse C, Waldron S, Yelon D, Thisse B, Stainier DY. casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes Dev. 2001 Jun 15; 15(12):1493-505. PMID: 11410530; PMCID: PMC312713.
      59. Yelon D, Ticho B, Halpern ME, Ruvinsky I, Ho RK, Silver LM, Stainier DY. The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development. 2000 Jun; 127(12):2573-82. PMID: 10821756.
        View in: PubMed
      60. Kikuchi Y, Trinh LA, Reiter JF, Alexander J, Yelon D, Stainier DY. The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes Dev. 2000 May 15; 14(10):1279-89. PMID: 10817762; PMCID: PMC316618.
      61. Griffin KJ, Stoller J, Gibson M, Chen S, Yelon D, Stainier DY, Kimelman D. A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. Dev Biol. 2000 Feb 15; 218(2):235-47. PMID: 10656766.
        View in: PubMed
      62. Reiter JF, Alexander J, Rodaway A, Yelon D, Patient R, Holder N, Stainier DY. Gata5 is required for the development of the heart and endoderm in zebrafish. Genes Dev. 1999 Nov 15; 13(22):2983-95. PMID: 10580005; PMCID: PMC317161.
      63. Yelon D, Horne SA, Stainier DY. Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish. Dev Biol. 1999 Oct 01; 214(1):23-37. PMID: 10491254.
        View in: PubMed
      64. Yelon D, Schaefer KL, Berg LJ. Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development. J Immunol. 1999 Feb 01; 162(3):1348-58. PMID: 9973389.
        View in: PubMed
      65. Yelon D, Stainier DY. Patterning during organogenesis: genetic analysis of cardiac chamber formation. Semin Cell Dev Biol. 1999 Feb; 10(1):93-8. PMID: 10355033.
        View in: PubMed
      66. Alexander J, Stainier DY, Yelon D. Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning. Dev Genet. 1998; 22(3):288-99. PMID: 9621435.
        View in: PubMed
      67. Yelon D, Berg LJ. Structurally similar TCRs differ in their efficiency of positive selection. J Immunol. 1997 Jun 01; 158(11):5219-28. PMID: 9164939.
        View in: PubMed
      68. Takaesu NT, Lower JA, Yelon D, Robertson EJ, Bikoff EK. In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain. J Immunol. 1997 Jan 01; 158(1):187-99. PMID: 8977190.
        View in: PubMed
      69. Yelon D, Spain LM, Lim K, Berg LJ. Alterations in CD4 dependence accompany T cell development and differentiation. Int Immunol. 1996 Jul; 8(7):1077-90. PMID: 8757953.
        View in: PubMed
      70. Stowers L, Yelon D, Berg LJ, Chant J. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):5027-31. PMID: 7761442; PMCID: PMC41841.
      71. Spain LM, Yelon D, Berg LJ. Do the CD4 and CD8 lineages represent parallel pathways? Semin Immunol. 1994 Aug; 6(4):213-20. PMID: 8000030.
        View in: PubMed
      72. Gatesy J, Yelon D, DeSalle R, Vrba ES. Phylogeny of the Bovidae (Artiodactyla, Mammalia), based on mitochondrial ribosomal DNA sequences. Mol Biol Evol. 1992 May; 9(3):433-46. PMID: 1584013.
        View in: PubMed
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