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    Arpi Minassian

    TitleClinical Professor
    SchoolUniversity of California, San Diego
    Address200 W. Arbor Drive #8620
    CA San Diego 92103
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      Dr. Minassian received her doctorate from the California School of Professional Psychology-San Diego. She completed her predoctoral internship in the UCSD Psychology Internship Training Program and continued at UCSD as a post-doctoral fellow in the NIMH Fellowship in Biological Psychiatry and Neuroscience. She joined the faculty of the Department of Psychiatry as an Assistant Project Scientist in July of 2004 and is currently a Clinical Professor. Her research laboratory is located on the inpatient Neuropsychiatry and Behavioral Medicine Service at the UCSD Medical Center in Hillcrest. She also serves a faculty psychologist at the Medical Center and a clinical supervisor in the Psychology Internship Training Program.

      Research Interests

      Dr. Minassian’s research program is focused upon understanding the relationship between biology and behavior in mental illness, medical illness, and substance abuse. Much of her research has implemented physiological and cognitive paradigms to understand brain dysfunction in psychiatric populations such as bipolar disorder, schizophrenia, PTSD, and substance addiction as well as neuromedical conditions such as HIV. The methodologies she has helped develop and implement can be translated to animals, an application which accelerates our understanding of biological mechanisms. She serves as Project Director in UCSD’s Translational Methamphetamine AIDS Research Center (TMARC) where she and her colleagues are studying decision making in HIV, methamphetamine dependence, and aging in humans and in rodent models. She is also a co-investigator on a number of NIH-funded studies of inhibitory and cognitive deficits in bipolar disorder. Dr. Minassian is a clinical psychologist and an attending clinician in the UCSD Health Systems. Her clinical area of expertise is consultation-liaison and she works with medically ill patients on the Burn Service, in the Pulmonary Rehabilitation Program, as well as with individuals with chronic pain and those awaiting organ transplantation. Furthermore she conducts clinical research with an interdisciplinary group of academicians outside the department of Psychiatry (e.g., Bariatric Surgery, Burn Surgery and Emergency Medicine). She is a member of the department’s Diversity Committee and also serves on university- and hospital-wide diversity focus groups.

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      Collapse Research Activities and Funding
      Translational Methamphetamine AIDS Research Center (TMARC)
      NIH/NIDA P50DA026306Dec 1, 2008 - May 31, 2019
      Role: Co-Investigator

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kwiatkowski MA, Hellemann G, Sugar CA, Cope ZA, Minassian A, Perry W, Geyer MA, Young JW. Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors. Pharmacol Biochem Behav. 2017 Dec 28. PMID: 29289701.
        View in: PubMed
      2. Milienne-Petiot M, Groenink L, Minassian A, Young JW. Blockade of dopamine D1-family receptors attenuates the mania-like hyperactive, risk-preferring, and high motivation behavioral profile of mice with low dopamine transporter levels. J Psychopharmacol. 2017 Sep 01; 269881117731162. PMID: 28950781.
        View in: PubMed
      3. Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, Zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundström J, Swenne CA, Syvänen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong Q, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Järvelin MR, Kääb S, Kähönen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimäki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC. Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun. 2017 Aug 02; 8:16140. PMID: 28767105.
        View in: PubMed
      4. Cope ZA, Minassian A, Kreitner D, MacQueen DA, Milienne-Petiot M, Geyer MA, Perry W, Young JW. Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species. Neuropharmacology. 2017 Oct; 125:254-262. PMID: 28774856.
        View in: PubMed
      5. Minassian A, Henry BL, Iudicello JE, Morgan EE, Letendre SL, Heaton RK, Perry W. Everyday functional ability in HIV and methamphetamine dependence. Drug Alcohol Depend. 2017 Jun 01; 175:60-66. PMID: 28399475.
        View in: PubMed
      6. Milienne-Petiot M, Kesby JP, Graves M, van Enkhuizen J, Semenova S, Minassian A, Markou A, Geyer MA, Young JW. The effects of reduced dopamine transporter function and chronic lithium on motivation, probabilistic learning, and neurochemistry in mice: Modeling bipolar mania. Neuropharmacology. 2017 Feb; 113(Pt A):260-270. PMID: 27732870.
        View in: PubMed
      7. Soontornniyomkij V, Kesby JP, Morgan EE, Bischoff-Grethe A, Minassian A, Brown GG, Grant I. Effects of HIV and Methamphetamine on Brain and Behavior: Evidence from Human Studies and Animal Models. J Neuroimmune Pharmacol. 2016 Sep; 11(3):495-510. PMID: 27484318; PMCID: PMC4985024 [Available on 09/01/17].
      8. Perry W, McIlwain M, Kloezeman K, Henry BL, Minassian A. Diagnosis and characterization of mania: Quantifying increased energy and activity in the human behavioral pattern monitor. Psychiatry Res. 2016 06 30; 240:278-283. PMID: 27138818; PMCID: PMC4885760 [Available on 06/30/17].
      9. Minassian A, Baker DG, Risbrough VB. Heart Rate Variability and Posttraumatic Stress Disorder. JAMA Psychiatry. 2016 Feb; 73(2):178-9. PMID: 26720754.
        View in: PubMed
      10. Young JW, Minassian A, Geyer MA. Locomotor Profiling from Rodents to the Clinic and Back Again. Curr Top Behav Neurosci. 2016; 28:287-303. PMID: 27418071.
        View in: PubMed
      11. Minassian A, Young JW, Cope ZA, Henry BL, Geyer MA, Perry W. Amphetamine increases activity but not exploration in humans and mice. Psychopharmacology (Berl). 2016 Jan; 233(2):225-33. PMID: 26449721; PMCID: PMC4703551 [Available on 01/01/17].
      12. Minassian A, Maihofer AX, Baker DG, Nievergelt CM, Geyer MA, Risbrough VB. Association of Predeployment Heart Rate Variability With Risk of Postdeployment Posttraumatic Stress Disorder in Active-Duty Marines. JAMA Psychiatry. 2015 Oct; 72(10):979-86. PMID: 26353072.
        View in: PubMed
      13. van Enkhuizen J, Geyer MA, Minassian A, Perry W, Henry BL, Young JW. Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies. Neurosci Biobehav Rev. 2015 Nov; 58:4-18. PMID: 26297513; PMCID: PMC4684462 [Available on 11/01/16].
      14. van Enkhuizen J, Janowsky DS, Olivier B, Minassian A, Perry W, Young JW, Geyer MA. The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited. Eur J Pharmacol. 2015 Apr 15; 753:114-26. PMID: 25107282; PMCID: PMC4318788.
      15. Morgan EE, Doyle KL, Minassian A, Henry BL, Perry W, Marcotte TD, Woods SP, Grant I. Elevated intraindividual variability in methamphetamine dependence is associated with poorer everyday functioning. Psychiatry Res. 2014 Dec 15; 220(1-2):527-34. PMID: 25081313; PMCID: PMC4252574.
      16. van Enkhuizen J, Henry BL, Minassian A, Perry W, Milienne-Petiot M, Higa KK, Geyer MA, Young JW. Reduced dopamine transporter functioning induces high-reward risk-preference consistent with bipolar disorder. Neuropsychopharmacology. 2014 Dec; 39(13):3112-22. PMID: 25005251; PMCID: PMC4229584.
      17. Minassian A, Geyer MA, Baker DG, Nievergelt CM, O'Connor DT, Risbrough VB. Heart rate variability characteristics in a large group of active-duty marines and relationship to posttraumatic stress. Psychosom Med. 2014 May; 76(4):292-301. PMID: 24804881; PMCID: PMC4062545.
      18. Patt VM, Thomas ML, Minassian A, Geyer MA, Brown GG, Perry W. Disentangling working memory processes during spatial span assessment: a modeling analysis of preferred eye movement strategies. J Clin Exp Neuropsychol. 2014; 36(2):186-204. PMID: 24499103; PMCID: PMC3970432.
      19. Henry BL, Geyer MA, Buell MR, Perry W, Young JW, Minassian A. Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine. Behav Pharmacol. 2014 Feb; 25(1):12-22. PMID: 24281153; PMCID: PMC3926694.
      20. Minassian A, Vilke GM, Wilson MP. Frequent emergency department visits are more prevalent in psychiatric, alcohol abuse, and dual diagnosis conditions than in chronic viral illnesses such as hepatitis and human immunodeficiency virus. J Emerg Med. 2013 Oct; 45(4):520-5. PMID: 23845528.
        View in: PubMed
      21. Henry BL, Minassian A, Patt VM, Hua J, Young JW, Geyer MA, Perry W. Inhibitory deficits in euthymic bipolar disorder patients assessed in the human behavioral pattern monitor. J Affect Disord. 2013 Sep 25; 150(3):948-54. PMID: 23759280; PMCID: PMC3759601.
      22. Henry BL, Minassian A, Perry W. Everyday functional ability across different phases of bipolar disorder. Psychiatry Res. 2013 Dec 30; 210(3):850-6. PMID: 23643188; PMCID: PMC3758417.
      23. van Enkhuizen J, Minassian A, Young JW. Further evidence for Clock?19 mice as a model for bipolar disorder mania using cross-species tests of exploration and sensorimotor gating. Behav Brain Res. 2013 Jul 15; 249:44-54. PMID: 23623885; PMCID: PMC3672322.
      24. Minassian A, Henry BL, Woods SP, Vaida F, Grant I, Geyer MA, Perry W. Prepulse inhibition in HIV-associated neurocognitive disorders. J Int Neuropsychol Soc. 2013 Jul; 19(6):709-17. PMID: 23552464; PMCID: PMC3729041.
      25. Henry BL, Geyer MA, Buell M, Perry W, Young JW, Minassian A. Behavioral effects of chronic methamphetamine treatment in HIV-1 gp120 transgenic mice. Behav Brain Res. 2013 Jan 01; 236(1):210-20. PMID: 22960458; PMCID: PMC3482284.
      26. Feifel D, Macdonald K, Cobb P, Minassian A. Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia. Schizophr Res. 2012 Aug; 139(1-3):207-10. PMID: 22682705.
        View in: PubMed
      27. MacDonald K, Wilson M, Minassian A, Vilke GM, Becker O, Tallian K, Cobb P, Perez R, Galangue B, Feifel D. A naturalistic study of intramuscular haloperidol versus intramuscular olanzapine for the management of acute agitation. J Clin Psychopharmacol. 2012 Jun; 32(3):317-22. PMID: 22544013.
        View in: PubMed
      28. Minassian A, Henry BL, Young JW, Masten V, Geyer MA, Perry W. Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individuals. PLoS One. 2011; 6(8):e24185. PMID: 21912623; PMCID: PMC3166173.
      29. Henry BL, Minassian A, van Rhenen M, Young JW, Geyer MA, Perry W. Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm. Psychopharmacology (Berl). 2011 Jun; 215(4):697-707. PMID: 21279333; PMCID: PMC3102201.
      30. Henry BL, Minassian A, Perry W. Effect of methamphetamine dependence on heart rate variability. Addict Biol. 2012 May; 17(3):648-58. PMID: 21182570; PMCID: PMC3117088.
      31. Minassian A, Young JW. Evaluation of the clinical efficacy of asenapine in schizophrenia. Expert Opin Pharmacother. 2010 Aug; 11(12):2107-15. PMID: 20642375; PMCID: PMC2924192.
      32. Feifel D, Macdonald K, Nguyen A, Cobb P, Warlan H, Galangue B, Minassian A, Becker O, Cooper J, Perry W, Lefebvre M, Gonzales J, Hadley A. Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients. Biol Psychiatry. 2010 Oct 01; 68(7):678-80. PMID: 20615494.
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      33. MacDonald K, Wilson MP, Minassian A, Vilke GM, Perez R, Cobb P, Tallian K, Becker O, Feifel D. A retrospective analysis of intramuscular haloperidol and intramuscular olanzapine in the treatment of agitation in drug- and alcohol-using patients. Gen Hosp Psychiatry. 2010 Jul-Aug; 32(4):443-5. PMID: 20633750.
        View in: PubMed
      34. Perry W, Minassian A, Henry B, Kincaid M, Young JW, Geyer MA. Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm. Psychiatry Res. 2010 Jun 30; 178(1):84-91. PMID: 20471103; PMCID: PMC2914139.
      35. Henry BL, Minassian A, Young JW, Paulus MP, Geyer MA, Perry W. Cross-species assessments of motor and exploratory behavior related to bipolar disorder. Neurosci Biobehav Rev. 2010 Jul; 34(8):1296-306. PMID: 20398694; PMCID: PMC2900445.
      36. Young JW, Goey AK, Minassian A, Perry W, Paulus MP, Geyer MA. The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administration. Pharmacol Biochem Behav. 2010 Jul; 96(1):7-15. PMID: 20363246; PMCID: PMC2878916.
      37. Henry BL, Minassian A, Perry W. Effect of methamphetamine dependence on everyday functional ability. Addict Behav. 2010 Jun; 35(6):593-8. PMID: 20167435; PMCID: PMC2839012.
      38. Minassian A, Henry BL, Geyer MA, Paulus MP, Young JW, Perry W. The quantitative assessment of motor activity in mania and schizophrenia. J Affect Disord. 2010 Jan; 120(1-3):200-6. PMID: 19435640; PMCID: PMC2795051.
      39. Young JW, Goey AK, Minassian A, Perry W, Paulus MP, Geyer MA. GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior. Psychopharmacology (Berl). 2010 Feb; 208(3):443-54. PMID: 20020109; PMCID: PMC2806531.
      40. Perry W, Minassian A, Paulus MP, Young JW, Kincaid MJ, Ferguson EJ, Henry BL, Zhuang X, Masten VL, Sharp RF, Geyer MA. A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. Arch Gen Psychiatry. 2009 Oct; 66(10):1072-80. PMID: 19805697; PMCID: PMC2897252.
      41. Henry BL, Minassian A, Paulus MP, Geyer MA, Perry W. Heart rate variability in bipolar mania and schizophrenia. J Psychiatr Res. 2010 Feb; 44(3):168-76. PMID: 19700172; PMCID: PMC2822123.
      42. Chan VT, Woo BK, Sewell DD, Allen EC, Golshan S, Rice V, Minassian A, Daly JW. Reduction of suboptimal prescribing and clinical outcome for dementia patients in a senior behavioral health inpatient unit. Int Psychogeriatr. 2009 Feb; 21(1):195-9. PMID: 19019261.
        View in: PubMed
      43. Feifel D, Minassian A, Perry W. Prepulse inhibition of startle in adults with ADHD. J Psychiatr Res. 2009 Jan; 43(4):484-9. PMID: 18674783; PMCID: PMC2669714.
      44. Young JW, Minassian A, Paulus MP, Geyer MA, Perry W. A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern Monitor. Neurosci Biobehav Rev. 2007; 31(6):882-96. PMID: 17706782; PMCID: PMC2025688.
      45. Harris JG, Minassian A, Perry W. Stability of attention deficits in schizophrenia. Schizophr Res. 2007 Mar; 91(1-3):107-11. PMID: 17306962.
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      46. Minassian A, Paulus M, Lincoln A, Perry W. Adults with autism show increased sensitivity to outcomes at low error rates during decision-making. J Autism Dev Disord. 2007 Aug; 37(7):1279-88. PMID: 17080271.
        View in: PubMed
      47. Minassian A, Feifel D, Perry W. The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients. Schizophr Res. 2007 Jan; 89(1-3):225-31. PMID: 17005374; PMCID: PMC2676911.
      48. Perry W, Minassian A, Lopez B, Maron L, Lincoln A. Sensorimotor gating deficits in adults with autism. Biol Psychiatry. 2007 Feb 15; 61(4):482-6. PMID: 16460695.
        View in: PubMed
      49. Minassian A, Granholm E, Verney S, Perry W. Visual scanning deficits in schizophrenia and their relationship to executive functioning impairment. Schizophr Res. 2005 Apr 01; 74(1):69-79. PMID: 15694756.
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      50. Swerdlow NR, Stephany N, Wasserman LC, Talledo J, Sharp R, Minassian A, Auerbach PP. Intact visual latent inhibition in schizophrenia patients in a within-subject paradigm. Schizophr Res. 2005 Jan 01; 72(2-3):169-83. PMID: 15560962.
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      51. Minassian A, Paulus MP, Perry W. Increased sensitivity to error during decision-making in bipolar disorder patients with acute mania. J Affect Disord. 2004 Oct 15; 82(2):203-8. PMID: 15488248.
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      52. Perry W, Minassian A, Feifel D. Prepulse inhibition in patients with non-psychotic major depressive disorder. J Affect Disord. 2004 Aug; 81(2):179-84. PMID: 15306146.
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      53. Maron LM, Carlson MD, Minassian A, Perry W. A process approach to verbal fluency in patients with schizophrenia. Schizophr Res. 2004 May 01; 68(1):105-6. PMID: 15037345.
        View in: PubMed
      54. Minassian A, Granholm E, Verney S, Perry W. Pupillary dilation to simple vs. complex tasks and its relationship to thought disturbance in schizophrenia patients. Int J Psychophysiol. 2004 Mar; 52(1):53-62. PMID: 15003372.
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      55. Minassian A, Perry W, Carlson M, Pelham M, DeFilippis N. The category test perseveration, loss of set, and memory scales: three new scales and their relationship to executive functioning measures. Assessment. 2003 Sep; 10(3):213-21. PMID: 14503644.
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      56. Perry W, Minassian A, Cadenhead K, Sprock J, Braff D. The use of the Ego Impairment Index across the schizophrenia spectrum. J Pers Assess. 2003 Feb; 80(1):50-7. PMID: 12584067.
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      57. Perry W, Feifel D, Minassian A, Bhattacharjie I, Braff DL. Information processing deficits in acutely psychotic schizophrenia patients medicated and unmedicated at the time of admission. Am J Psychiatry. 2002 Aug; 159(8):1375-81. PMID: 12153831.
        View in: PubMed
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