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Wendy Havran

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentDermatology
Address9500 Gilman Drive #0869
La Jolla CA 92093
Phone858-784-2742
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    Collapse Research 
    Collapse Research Activities and Funding
    2018 International gamma delta T cell conference
    NIH/NIAID R13AI138538Apr 1, 2018 - Mar 31, 2019
    Role: Principal Investigator
    Expression of gamma delta TCR ligands in development
    NIH/NIAID R21AI129401Feb 7, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Mechanism-Based Wound Healing by Activation of gamma delta T Cells
    NIH/NIAID R21AI119971Jul 2, 2015 - Jun 30, 2017
    Role: Principal Investigator
    CD1-lipid reactivity of epidermal T cells
    NIH/NIAMS R21AR067458Apr 8, 2015 - Jan 31, 2017
    Role: Principal Investigator
    Role of EPCR in gamma delta T cell wound healing functions
    NIH/NIAID R21AI107506Jun 5, 2013 - May 31, 2015
    Role: Principal Investigator
    2012 Gamma Delta T Cell Conference
    NIH/NIAID R13AI100519Mar 1, 2012 - Feb 28, 2013
    Role: Principal Investigator
    Identification of skin gamma delta T cell antigens
    NIH/NIAID R21AI095823Jun 1, 2011 - May 31, 2013
    Role: Principal Investigator
    2010 Gamma Delta T Cell Conference
    NIH/NIAID R13AI088868Apr 1, 2010 - Mar 31, 2011
    Role: Principal Investigator
    Gamma delta T cells and human wound healing
    NIH/NIGMS R01GM080301Jul 3, 2008 - Apr 30, 2012
    Role: Principal Investigator
    Gamma Delta T Cell Conference
    NIH/NIAID R13AI068398Mar 1, 2006 - Feb 28, 2007
    Role: Principal Investigator
    JAML: A New Costimulatory Molecule for Gamma Delta T Cells
    NIH/NIAID R01AI064811Apr 1, 2005 - Apr 30, 2017
    Role: Principal Investigator
    Visualization of gamma delta T cells in wound healing
    NIH/NIAID R21AI061685Jun 1, 2004 - May 31, 2007
    Role: Principal Investigator
    Coreceptors for skin gamma delta T cells
    NIH/NIAID R01AI052257Jun 1, 2002 - May 31, 2008
    Role: Principal Investigator
    Epithelial T Cell Secretion of Tissue Specific Cytokines
    NIH/NIAID R01AI036964Apr 1, 1996 - Apr 30, 2014
    Role: Principal Investigator
    T CELLS BEARING INVARIANT GAMMA DELTA RECEPTORS
    NIH/NIAID R01AI032751May 1, 1992 - Apr 30, 2004
    Role: Principal Investigator
    T CELLS BEARING INVARIANT GAMMA DELTA RECEPTORS
    NIH/NIAID R21AI032751May 1, 1992 - Jan 31, 2001
    Role: Principal Investigator
    T CELLS BEARING INVARIANT GAMMA DELTA RECEPTORS
    NIH/NIAID R29AI032751May 1, 1992 - Apr 30, 1998
    Role: Principal Investigator
    Immunology Training
    NIH/NIAID T32AI007244Jul 1, 1982 - Jun 30, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. McGraw JM, Havran WL. ?d T cells and IgE team up to prevent tumors. Nat Immunol. 2018 Aug; 19(8):793-795. PMID: 30013144.
      View in: PubMed
    2. Havran WL. Specialized Antitumor Functions for Skin ?d T Cells. J Immunol. 2018 May 01; 200(9):3029-3030. PMID: 29685948.
      View in: PubMed
    3. Witherden DA, Johnson MD, Havran WL. Coreceptors and Their Ligands in Epithelial ?d T Cell Biology. Front Immunol. 2018; 9:731. PMID: 29686687.
      View in: PubMed
    4. Lee P, Gund R, Dutta A, Pincha N, Rana I, Ghosh S, Witherden D, Kandyba E, MacLeod A, Kobielak K, Havran WL, Jamora C. Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of ?dT-cells. Elife. 2017 Dec 04; 6. PMID: 29199946.
      View in: PubMed
    5. Nielsen MM, Witherden DA, Havran WL. ?d T cells in homeostasis and host defence of epithelial barrier tissues. Nat Rev Immunol. 2017 Dec; 17(12):733-745. PMID: 28920588.
      View in: PubMed
    6. Adams EJ, Havran WL. Introduction to Cellular Immunology Special Issue on ?d T cells. Cell Immunol. 2015 Jul; 296(1):1-2. PMID: 26070929.
      View in: PubMed
    7. Ramirez K, Witherden DA, Havran WL. All hands on DE(T)C: Epithelial-resident ?d T cells respond to tissue injury. Cell Immunol. 2015 Jul; 296(1):57-61. PMID: 25958272; PMCID: PMC4466205.
    8. Nielsen MM, Dyring-Andersen B, Schmidt JD, Witherden D, Lovato P, Woetmann A, Ødum N, Poulsen SS, Havran WL, Geisler C, Bonefeld CM. NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity. J Invest Dermatol. 2015 May; 135(5):1311-1319. PMID: 25634359; PMCID: PMC4402141.
    9. Witherden DA, Ramirez K, Havran WL. Multiple Receptor-Ligand Interactions Direct Tissue-Resident ?d T Cell Activation. Front Immunol. 2014; 5:602. PMID: 25505467; PMCID: PMC4241470.
    10. MacLeod AS, Rudolph R, Corriden R, Ye I, Garijo O, Havran WL. Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. J Immunol. 2014 Jun 15; 192(12):5695-702. PMID: 24808367; PMCID: PMC4048764.
    11. Nielsen MM, Lovato P, MacLeod AS, Witherden DA, Skov L, Dyring-Andersen B, Dabelsteen S, Woetmann A, Ødum N, Havran WL, Geisler C, Bonefeld CM. IL-1ß-dependent activation of dendritic epidermal T cells in contact hypersensitivity. J Immunol. 2014 Apr 01; 192(7):2975-83. PMID: 24600030; PMCID: PMC4020443.
    12. Kronenberg M, Havran WL. Immunology: oiling the wheels of autoimmunity. Nature. 2014 Feb 06; 506(7486):42-3. PMID: 24499914.
      View in: PubMed
    13. MacLeod AS, Hemmers S, Garijo O, Chabod M, Mowen K, Witherden DA, Havran WL. Dendritic epidermal T cells regulate skin antimicrobial barrier function. J Clin Invest. 2013 Oct; 123(10):4364-74. PMID: 24051381; PMCID: PMC3784546.
    14. Witherden DA, Havran WL. Cross-talk between intraepithelial ?d T cells and epithelial cells. J Leukoc Biol. 2013 Jul; 94(1):69-76. PMID: 23620015; PMCID: PMC3685022.
    15. Witherden DA, Havran WL. EPCR: a stress trigger for ?d T cells. Nat Immunol. 2012 Sep; 13(9):812-4. PMID: 22910386.
      View in: PubMed
    16. Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, Kumanogoh A, Kikutani H, Teyton L, Fischer WH, Havran WL. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal ?d T cell function. Immunity. 2012 Aug 24; 37(2):314-25. PMID: 22902232; PMCID: PMC3430606.
    17. Komori HK, Witherden DA, Kelly R, Sendaydiego K, Jameson JM, Teyton L, Havran WL. Cutting edge: dendritic epidermal ?d T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding. J Immunol. 2012 Apr 01; 188(7):2972-6. PMID: 22393149; PMCID: PMC3311739.
    18. Antsiferova M, Huber M, Meyer M, Piwko-Czuchra A, Ramadan T, MacLeod AS, Havran WL, Dummer R, Hohl D, Werner S. Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response. Nat Commun. 2011 Dec 06; 2:576. PMID: 22146395; PMCID: PMC3247817.
    19. Verdino P, Witherden DA, Podshivalova K, Rieder SE, Havran WL, Wilson IA. cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for ?d T cells. PLoS One. 2011; 6(5):e19828. PMID: 21629689.
      View in: PubMed
    20. Macleod AS, Havran WL. Functions of skin-resident ?d T cells. Cell Mol Life Sci. 2011 Jul; 68(14):2399-408. PMID: 21560071; PMCID: PMC3123394.
    21. Witherden DA, Havran WL. Molecular aspects of epithelial ?d T cell regulation. Trends Immunol. 2011 Jun; 32(6):265-71. PMID: 21481636; PMCID: PMC3109268.
    22. Verdino P, Witherden DA, Ferguson MS, Corper AL, Schiefner A, Havran WL, Wilson IA. Molecular insights into ?d T cell costimulation by an anti-JAML antibody. Structure. 2011 Jan 12; 19(1):80-9. PMID: 21220118; PMCID: PMC3039130.
    23. Witherden DA, Havran WL. Costimulating epithelial ?d T cells. Cell Cycle. 2011 Jan 01; 10(1):4-5. PMID: 21191174.
      View in: PubMed
    24. Witherden DA, Verdino P, Rieder SE, Garijo O, Mills RE, Teyton L, Fischer WH, Wilson IA, Havran WL. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science. 2010 Sep 03; 329(5996):1205-10. PMID: 20813954; PMCID: PMC2943937.
    25. Verdino P, Witherden DA, Havran WL, Wilson IA. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science. 2010 Sep 03; 329(5996):1210-4. PMID: 20813955; PMCID: PMC2951132.
    26. Swamy M, Jamora C, Havran W, Hayday A. Epithelial decision makers: in search of the 'epimmunome'. Nat Immunol. 2010 Aug; 11(8):656-65. PMID: 20644571.
      View in: PubMed
    27. Havran WL, Jameson JM. Epidermal T cells and wound healing. J Immunol. 2010 May 15; 184(10):5423-8. PMID: 20483798; PMCID: PMC2944652.
    28. Toulon A, Breton L, Taylor KR, Tenenhaus M, Bhavsar D, Lanigan C, Rudolph R, Jameson J, Havran WL. A role for human skin-resident T cells in wound healing. J Exp Med. 2009 Apr 13; 206(4):743-50. PMID: 19307328; PMCID: PMC2715110.
    29. Kim CH, Witherden DA, Havran WL. Characterization and TCR variable region gene use of mouse resident nasal gammadelta T lymphocytes. J Leukoc Biol. 2008 Nov; 84(5):1259-63. PMID: 18667688; PMCID: PMC2567898.
    30. Yu D, Cook MC, Shin DM, Silva DG, Marshall J, Toellner KM, Havran WL, Caroni P, Cooke MP, Morse HC, MacLennan IC, Goodnow CC, Vinuesa CG. Axon growth and guidance genes identify T-dependent germinal centre B cells. Immunol Cell Biol. 2008 Jan; 86(1):3-14. PMID: 17938642.
      View in: PubMed
    31. Jameson J, Havran WL. Skin gammadelta T-cell functions in homeostasis and wound healing. Immunol Rev. 2007 Feb; 215:114-22. PMID: 17291283.
      View in: PubMed
    32. Kronenberg M, Havran WL. Frontline T cells: gammadelta T cells and intraepithelial lymphocytes. Immunol Rev. 2007 Feb; 215:5-7. PMID: 17291274.
      View in: PubMed
    33. Komori HK, Meehan TF, Havran WL. Epithelial and mucosal gamma delta T cells. Curr Opin Immunol. 2006 Oct; 18(5):534-8. PMID: 16837181.
      View in: PubMed
    34. Havran WL, Jameson JM, Witherden DA. Epithelial cells and their neighbors. III. Interactions between intraepithelial lymphocytes and neighboring epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 289(4):G627-30. PMID: 16160077.
      View in: PubMed
    35. Jameson JM, Cauvi G, Sharp LL, Witherden DA, Havran WL. Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammation. J Exp Med. 2005 Apr 18; 201(8):1269-79. PMID: 15837812; PMCID: PMC2213158.
    36. Baccala R, Witherden D, Gonzalez-Quintial R, Dummer W, Surh CD, Havran WL, Theofilopoulos AN. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol. 2005 Apr 15; 174(8):4606-12. PMID: 15814683.
      View in: PubMed
    37. Sharp LL, Jameson JM, Witherden DA, Komori HK, Havran WL. Dendritic epidermal T-cell activation. Crit Rev Immunol. 2005; 25(1):1-18. PMID: 15833080.
      View in: PubMed
    38. Sharp LL, Jameson JM, Cauvi G, Havran WL. Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1. Nat Immunol. 2005 Jan; 6(1):73-9. PMID: 15592472.
      View in: PubMed
    39. Jameson JM, Sharp LL, Witherden DA, Havran WL. Regulation of skin cell homeostasis by gamma delta T cells. Front Biosci. 2004 Sep 01; 9:2640-51. PMID: 15358587.
      View in: PubMed
    40. Yui MA, Sharp LL, Havran WL, Rothenberg EV. Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation. J Immunol. 2004 Apr 15; 172(8):4691-9. PMID: 15067044.
      View in: PubMed
    41. Jameson JM, Cauvi G, Witherden DA, Havran WL. A keratinocyte-responsive gamma delta TCR is necessary for dendritic epidermal T cell activation by damaged keratinocytes and maintenance in the epidermis. J Immunol. 2004 Mar 15; 172(6):3573-9. PMID: 15004158.
      View in: PubMed
    42. Jameson J, Witherden D, Havran WL. T-cell effector mechanisms: gammadelta and CD1d-restricted subsets. Curr Opin Immunol. 2003 Jun; 15(3):349-53. PMID: 12787763.
      View in: PubMed
    43. Chen Y, Chou K, Fuchs E, Havran WL, Boismenu R. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14338-43. PMID: 12376619; PMCID: PMC137885.
    44. Jameson J, Ugarte K, Chen N, Yachi P, Fuchs E, Boismenu R, Havran WL. A role for skin gammadelta T cells in wound repair. Science. 2002 Apr 26; 296(5568):747-9. PMID: 11976459.
      View in: PubMed
    45. Meharra EJ, Schön M, Hassett D, Parker C, Havran W, Gardner H. Reduced gut intraepithelial lymphocytes in VLA1 null mice. Cell Immunol. 2000 Apr 10; 201(1):1-5. PMID: 10805967.
      View in: PubMed
    46. Punt JA, Havran W, Abe R, Sarin A, Singer A. T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus. J Exp Med. 1997 Dec 01; 186(11):1911-22. PMID: 9382889; PMCID: PMC2199155.
    47. Dialynas DP, Wilde DB, Marrack P, Pierres A, Wall KA, Havran W, Otten G, Loken MR, Pierres M, Kappler J. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev. 1983; 74:29-56. PMID: 6195085.
      View in: PubMed
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