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Gerald Joyce

Title(s)Adjunct Professor, Pharmacology
SchoolHealth Sciences
Phone858-453-4100
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    Collapse Research 
    Collapse Research Activities and Funding
    Ligand-Dependent Exponential Amplification of RNA
    NIH/NIGMS R01GM065130Apr 1, 2002 - Nov 30, 2015
    Role: Principal Investigator
    CATALYTIC RNA AND DNA AS ANTIHIV 1 THERAPEUTIC AGENTS
    NIH/NIAID R01AI030882Dec 1, 1990 - Mar 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Horning DP, Bala S, Chaput JC, Joyce GF. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. ACS Synth Biol. 2019 May 17; 8(5):955-961. PMID: 31042360.
      View in: PubMed
    2. Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA. J Am Chem Soc. 2019 Apr 17; 141(15):6213-6223. PMID: 30912655.
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    3. Samanta B, Horning DP, Joyce GF. 3'-End labeling of nucleic acids by a polymerase ribozyme. Nucleic Acids Res. 2018 Sep 28; 46(17):e103. PMID: 29901762.
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    4. Joyce GF, Szostak JW. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018 09 04; 10(9). PMID: 30181195.
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    5. Samanta B, Joyce GF. A reverse transcriptase ribozyme. Elife. 2017 09 26; 6. PMID: 28949294.
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    6. Olea C, Joyce GF. Real-Time Detection of a Self-Replicating RNA Enzyme. Molecules. 2016 Sep 30; 21(10). PMID: 27706059.
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    7. Horning DP, Joyce GF. Amplification of RNA by an RNA polymerase ribozyme. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9786-91. PMID: 27528667.
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    8. Sczepanski JT, Joyce GF. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. J Am Chem Soc. 2015 Dec 30; 137(51):16032-7. PMID: 26652064.
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    9. Joyce GF. Reflections of a Darwinian Engineer. J Mol Evol. 2015 Dec; 81(5-6):146-9. PMID: 26597943.
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    10. Olea C, Weidmann J, Dawson PE, Joyce GF. An L-RNA Aptamer that Binds and Inhibits RNase. Chem Biol. 2015 Nov 19; 22(11):1437-1441. PMID: 26590636.
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    11. Olea C, Joyce GF. Ligand-dependent exponential amplification of self-replicating RNA enzymes. Methods Enzymol. 2015; 550:23-39. PMID: 25605379.
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    12. Sczepanski JT, Joyce GF. A cross-chiral RNA polymerase ribozyme. Nature. 2014 Nov 20; 515(7527):440-2. PMID: 25363769.
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    13. Breaker RR, Joyce GF. The expanding view of RNA and DNA function. Chem Biol. 2014 Sep 18; 21(9):1059-65. PMID: 25237854.
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    14. Petrie KL, Joyce GF. Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. J Mol Evol. 2014 Oct; 79(3-4):75-90. PMID: 25155818.
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    15. Robertson MP, Joyce GF. Highly efficient self-replicating RNA enzymes. Chem Biol. 2014 Feb 20; 21(2):238-45. PMID: 24388759.
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    16. Sczepanski JT, Joyce GF. Binding of a structured D-RNA molecule by an L-RNA aptamer. J Am Chem Soc. 2013 Sep 11; 135(36):13290-3. PMID: 23977945.
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    17. Ferretti AC, Joyce GF. Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. Biochemistry. 2013 Feb 19; 52(7):1227-35. PMID: 23384307.
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    18. Sczepanski JT, Joyce GF. Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. Chem Biol. 2012 Oct 26; 19(10):1324-32. PMID: 23102225.
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    19. Joyce GF. Bit by bit: the Darwinian basis of life. PLoS Biol. 2012; 10(5):e1001323. PMID: 22589698.
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    20. Olea C, Horning DP, Joyce GF. Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. J Am Chem Soc. 2012 May 16; 134(19):8050-3. PMID: 22551009.
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    21. Robertson MP, Joyce GF. The origins of the RNA world. Cold Spring Harb Perspect Biol. 2012 May 01; 4(5). PMID: 20739415.
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    22. Joyce GF. Evolution. Toward an alternative biology. Science. 2012 Apr 20; 336(6079):307-8. PMID: 22517850.
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    23. Lam BJ, Joyce GF. An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. J Am Chem Soc. 2011 Mar 09; 133(9):3191-7. PMID: 21322594.
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    24. Petrie KL, Joyce GF. Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. Nucleic Acids Res. 2010 Dec; 38(22):8095-104. PMID: 20693528.
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    25. Paegel BM, Joyce GF. Microfluidic compartmentalized directed evolution. Chem Biol. 2010 Jul 30; 17(7):717-24. PMID: 20659684.
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    26. Voytek SB, Joyce GF. Niche partitioning in the coevolution of 2 distinct RNA enzymes. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7780-5. PMID: 19416904.
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    27. Lam BJ, Joyce GF. Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. Nat Biotechnol. 2009 Mar; 27(3):288-92. PMID: 19234448.
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    28. Lincoln TA, Joyce GF. Self-sustained replication of an RNA enzyme. Science. 2009 Feb 27; 323(5918):1229-32. PMID: 19131595.
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    29. Paegel BM, Joyce GF. Darwinian evolution on a chip. PLoS Biol. 2008 Apr 08; 6(4):e85. PMID: 18399721.
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    30. Joyce GF. Obituary: Leslie Orgel (1927-2007). Nature. 2007 Nov 29; 450(7170):627. PMID: 18046392.
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    31. Voytek SB, Joyce GF. Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15288-93. PMID: 17878292.
      View in: PubMed
    32. Joyce GF. Structural biology. A glimpse of biology's first enzyme. Science. 2007 Mar 16; 315(5818):1507-8. PMID: 17363651.
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    33. Joyce GF. Forty years of in vitro evolution. Angew Chem Int Ed Engl. 2007; 46(34):6420-36. PMID: 17634987.
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    34. Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF. Microfluidic serial dilution circuit. Anal Chem. 2006 Nov 01; 78(21):7522-7. PMID: 17073422.
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    35. Cadwell RC, Joyce GF. Mutagenic PCR. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485544.
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    36. Paul N, Springsteen G, Joyce GF. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. Chem Biol. 2006 Mar; 13(3):329-38. PMID: 16638538.
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    37. Oberhuber M, Joyce GF. A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. Angew Chem Int Ed Engl. 2005 Nov 25; 44(46):7580-3. PMID: 16240312.
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    38. Johns GC, Joyce GF. The promise and peril of continuous in vitro evolution. J Mol Evol. 2005 Aug; 61(2):253-63. PMID: 15999246.
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    39. Paul N, Joyce GF. Minimal self-replicating systems. Curr Opin Chem Biol. 2004 Dec; 8(6):634-9. PMID: 15556408.
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    40. Kim DE, Joyce GF. Cross-catalytic replication of an RNA ligase ribozyme. Chem Biol. 2004 Nov; 11(11):1505-12. PMID: 15556001.
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    41. Springsteen G, Joyce GF. Selective derivatization and sequestration of ribose from a prebiotic mix. J Am Chem Soc. 2004 Aug 11; 126(31):9578-83. PMID: 15291561.
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    42. Shih WM, Quispe JD, Joyce GF. A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature. 2004 Feb 12; 427(6975):618-21. PMID: 14961116.
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    43. Joyce GF. Directed evolution of nucleic acid enzymes. Annu Rev Biochem. 2004; 73:791-836. PMID: 15189159.
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    44. Kühne H, Joyce GF. Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. J Mol Evol. 2003 Sep; 57(3):292-8. PMID: 14629039.
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    45. Kumar RM, Joyce GF. A modular, bifunctional RNA that integrates itself into a target RNA. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9738-43. PMID: 12913125.
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    46. Kuhns ST, Joyce GF. Perfectly complementary nucleic acid enzymes. J Mol Evol. 2003 Jun; 56(6):711-7. PMID: 12911034.
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    47. Paul N, Joyce GF. Self-replication. Curr Biol. 2003 Jan 21; 13(2):R46. PMID: 12546800.
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    48. McGinness KE, Joyce GF. In search of an RNA replicase ribozyme. Chem Biol. 2003 Jan; 10(1):5-14. PMID: 12573693.
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    49. Reader JS, Joyce GF. A ribozyme composed of only two different nucleotides. Nature. 2002 Dec 19-26; 420(6917):841-4. PMID: 12490955.
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    50. Joyce GF. Molecular evolution: booting up life. Nature. 2002 Nov 21; 420(6913):278-9. PMID: 12447426.
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    51. Ordoukhanian P, Joyce GF. RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. J Am Chem Soc. 2002 Oct 23; 124(42):12499-506. PMID: 12381192.
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    52. Paul N, Joyce GF. A self-replicating ligase ribozyme. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12733-40. PMID: 12239349.
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    53. Joyce GF. The antiquity of RNA-based evolution. Nature. 2002 Jul 11; 418(6894):214-21. PMID: 12110897.
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    54. McGinness KE, Wright MC, Joyce GF. Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. Chem Biol. 2002 May; 9(5):585-96. PMID: 12031665.
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    55. McGinness KE, Joyce GF. RNA-catalyzed RNA ligation on an external RNA template. Chem Biol. 2002 Mar; 9(3):297-307. PMID: 11927255.
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    56. McGinness KE, Joyce GF. Substitution of ribonucleotides in the T7 RNA polymerase promoter element. J Biol Chem. 2002 Jan 25; 277(4):2987-91. PMID: 11704669.
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