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Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA. J Am Chem Soc. 2021 11 17; 143(45):19160-19166.
Bare GAL, Joyce GF. PMID: 34731573.
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1 Fields:
Translation:
Cells
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Witnessing the structural evolution of an RNA enzyme. Elife. 2021 09 09; 10.
Portillo X, Huang YT, Breaker RR, Horning DP, Joyce GF. PMID: 34498588; PMCID: PMC8460264.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Kinetic Effects of β,γ-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA. Biochemistry. 2021 01 12; 60(1):1-5.
Setterholm NA, Haratipour P, Kashemirov BA, McKenna CE, Joyce GF. PMID: 33356161; PMCID: PMC8024617.
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HumansCells
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RNA-Catalyzed Cross-Chiral Polymerization of RNA. J Am Chem Soc. 2020 09 09; 142(36):15331-15339.
Tjhung KF, Sczepanski JT, Murtfeldt ER, Joyce GF. PMID: 32805113.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Thermal Habitat for RNA Amplification and Accumulation. Phys Rev Lett. 2020 Jul 24; 125(4):048104.
Salditt A, Keil LMR, Horning DP, Mast CB, Joyce GF, Braun D. PMID: 32794805.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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An RNA polymerase ribozyme that synthesizes its own ancestor. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):2906-2913.
Tjhung KF, Shokhirev MN, Horning DP, Joyce GF. PMID: 31988127; PMCID: PMC7022166.
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PubMed Mentions:
19 Fields:
Translation:
Cells
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RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. ACS Synth Biol. 2019 05 17; 8(5):955-961.
Horning DP, Bala S, Chaput JC, Joyce GF. PMID: 31042360; PMCID: PMC8111818.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA. J Am Chem Soc. 2019 04 17; 141(15):6213-6223.
Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. PMID: 30912655; PMCID: PMC6548421.
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PubMed Mentions:
28 Fields:
Translation:
Cells
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3'-End labeling of nucleic acids by a polymerase ribozyme. Nucleic Acids Res. 2018 09 28; 46(17):e103.
Samanta B, Horning DP, Joyce GF. PMID: 29901762; PMCID: PMC6158495.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018 09 04; 10(9).
Joyce GF, Szostak JW. PMID: 30181195; PMCID: PMC6120706.
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PubMed Mentions:
65 Fields:
Translation:
Cells
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A reverse transcriptase ribozyme. Elife. 2017 09 26; 6.
Samanta B, Joyce GF. PMID: 28949294; PMCID: PMC5665644.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Real-Time Detection of a Self-Replicating RNA Enzyme. Molecules. 2016 Sep 30; 21(10).
Olea C, Joyce GF. PMID: 27706059; PMCID: PMC5108293.
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PubMed Mentions:
4 Fields:
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Amplification of RNA by an RNA polymerase ribozyme. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9786-91.
Horning DP, Joyce GF. PMID: 27528667; PMCID: PMC5024611.
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PubMed Mentions:
75 Fields:
Translation:
Cells
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Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. J Am Chem Soc. 2015 Dec 30; 137(51):16032-7.
Sczepanski JT, Joyce GF. PMID: 26652064; PMCID: PMC4703082.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Reflections of a Darwinian Engineer. J Mol Evol. 2015 Dec; 81(5-6):146-9.
Joyce GF. PMID: 26597943; PMCID: PMC5257008.
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PubMed Mentions:
2 Fields:
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An L-RNA Aptamer that Binds and Inhibits RNase. Chem Biol. 2015 Nov 19; 22(11):1437-1441.
Olea C, Weidmann J, Dawson PE, Joyce GF. PMID: 26590636; PMCID: PMC4656138.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Ligand-dependent exponential amplification of self-replicating RNA enzymes. Methods Enzymol. 2015; 550:23-39.
Olea C, Joyce GF. PMID: 25605379; PMCID: PMC5103853.
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PubMed Mentions: Fields:
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Cells
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A cross-chiral RNA polymerase ribozyme. Nature. 2014 Nov 20; 515(7527):440-2.
Sczepanski JT, Joyce GF. PMID: 25363769; PMCID: PMC4239201.
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PubMed Mentions:
56 Fields:
Translation:
Cells
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The expanding view of RNA and DNA function. Chem Biol. 2014 Sep 18; 21(9):1059-65.
Breaker RR, Joyce GF. PMID: 25237854; PMCID: PMC4171699.
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PubMed Mentions:
30 Fields:
Translation:
Cells
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Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. J Mol Evol. 2014 Oct; 79(3-4):75-90.
Petrie KL, Joyce GF. PMID: 25155818; PMCID: PMC4185262.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Highly efficient self-replicating RNA enzymes. Chem Biol. 2014 Feb 20; 21(2):238-45.
Robertson MP, Joyce GF. PMID: 24388759; PMCID: PMC3943892.
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PubMed Mentions:
26 Fields:
Translation:
Cells
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Binding of a structured D-RNA molecule by an L-RNA aptamer. J Am Chem Soc. 2013 Sep 11; 135(36):13290-3.
Sczepanski JT, Joyce GF. PMID: 23977945; PMCID: PMC3804424.
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PubMed Mentions:
25 Fields:
Translation:
Cells
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Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. Biochemistry. 2013 Feb 19; 52(7):1227-35.
Ferretti AC, Joyce GF. PMID: 23384307; PMCID: PMC3579227.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. Chem Biol. 2012 Oct 26; 19(10):1324-32.
Sczepanski JT, Joyce GF. PMID: 23102225; PMCID: PMC3483592.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Bit by bit: the Darwinian basis of life. PLoS Biol. 2012; 10(5):e1001323.
Joyce GF. PMID: 22589698; PMCID: PMC3348159.
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PubMed Mentions:
18 Fields:
Translation:
Cells
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Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. J Am Chem Soc. 2012 May 16; 134(19):8050-3.
Olea C, Horning DP, Joyce GF. PMID: 22551009; PMCID: PMC3357125.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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The origins of the RNA world. Cold Spring Harb Perspect Biol. 2012 May 01; 4(5).
Robertson MP, Joyce GF. PMID: 20739415; PMCID: PMC3331698.
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PubMed Mentions:
154 Fields:
Translation:
Cells
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Evolution. Toward an alternative biology. Science. 2012 Apr 20; 336(6079):307-8.
Joyce GF. PMID: 22517850.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. J Am Chem Soc. 2011 Mar 09; 133(9):3191-7.
Lam BJ, Joyce GF. PMID: 21322594; PMCID: PMC3048896.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. Nucleic Acids Res. 2010 Dec; 38(22):8095-104.
Petrie KL, Joyce GF. PMID: 20693528; PMCID: PMC3001061.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Microfluidic compartmentalized directed evolution. Chem Biol. 2010 Jul 30; 17(7):717-24.
Paegel BM, Joyce GF. PMID: 20659684; PMCID: PMC2912841.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Niche partitioning in the coevolution of 2 distinct RNA enzymes. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7780-5.
Voytek SB, Joyce GF. PMID: 19416904; PMCID: PMC2683078.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. Nat Biotechnol. 2009 Mar; 27(3):288-92.
Lam BJ, Joyce GF. PMID: 19234448; PMCID: PMC2695811.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Self-sustained replication of an RNA enzyme. Science. 2009 Feb 27; 323(5918):1229-32.
Lincoln TA, Joyce GF. PMID: 19131595; PMCID: PMC2652413.
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PubMed Mentions:
200 Fields:
Translation:
Cells
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Darwinian evolution on a chip. PLoS Biol. 2008 Apr 08; 6(4):e85.
Paegel BM, Joyce GF. PMID: 18399721; PMCID: PMC2288630.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Obituary: Leslie Orgel (1927-2007). Nature. 2007 Nov 29; 450(7170):627.
Joyce GF. PMID: 18046392.
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PubMed Mentions: Fields:
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Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15288-93.
Voytek SB, Joyce GF. PMID: 17878292; PMCID: PMC2000504.
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PubMed Mentions:
22 Fields:
Translation:
Cells
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Structural biology. A glimpse of biology's first enzyme. Science. 2007 Mar 16; 315(5818):1507-8.
Joyce GF. PMID: 17363651.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Forty years of in vitro evolution. Angew Chem Int Ed Engl. 2007; 46(34):6420-36.
Joyce GF. PMID: 17634987.
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PubMed Mentions:
86 Fields:
Translation:
HumansAnimals
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Microfluidic serial dilution circuit. Anal Chem. 2006 Nov 01; 78(21):7522-7.
Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF. PMID: 17073422; PMCID: PMC2566538.
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PubMed Mentions:
13 Fields:
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Mutagenic PCR. CSH Protoc. 2006 Jun 01; 2006(1).
Cadwell RC, Joyce GF. PMID: 22485544.
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PubMed Mentions:
3
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Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. Chem Biol. 2006 Mar; 13(3):329-38.
Paul N, Springsteen G, Joyce GF. PMID: 16638538.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. Angew Chem Int Ed Engl. 2005 Nov 25; 44(46):7580-3.
Oberhuber M, Joyce GF. PMID: 16240312.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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The promise and peril of continuous in vitro evolution. J Mol Evol. 2005 Aug; 61(2):253-63.
Johns GC, Joyce GF. PMID: 15999246.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Minimal self-replicating systems. Curr Opin Chem Biol. 2004 Dec; 8(6):634-9.
Paul N, Joyce GF. PMID: 15556408.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Cross-catalytic replication of an RNA ligase ribozyme. Chem Biol. 2004 Nov; 11(11):1505-12.
Kim DE, Joyce GF. PMID: 15556001.
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PubMed Mentions:
31 Fields:
Translation:
Cells
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Selective derivatization and sequestration of ribose from a prebiotic mix. J Am Chem Soc. 2004 Aug 11; 126(31):9578-83.
Springsteen G, Joyce GF. PMID: 15291561.
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PubMed Mentions:
31 Fields:
Translation:
Cells
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A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature. 2004 Feb 12; 427(6975):618-21.
Shih WM, Quispe JD, Joyce GF. PMID: 14961116.
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PubMed Mentions:
166 Fields:
Translation:
Cells
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Directed evolution of nucleic acid enzymes. Annu Rev Biochem. 2004; 73:791-836.
Joyce GF. PMID: 15189159.
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PubMed Mentions:
145 Fields:
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Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. J Mol Evol. 2003 Sep; 57(3):292-8.
Kühne H, Joyce GF. PMID: 14629039.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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A modular, bifunctional RNA that integrates itself into a target RNA. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9738-43.
Kumar RM, Joyce GF. PMID: 12913125; PMCID: PMC187835.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Perfectly complementary nucleic acid enzymes. J Mol Evol. 2003 Jun; 56(6):711-7.
Kuhns ST, Joyce GF. PMID: 12911034.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Self-replication. Curr Biol. 2003 Jan 21; 13(2):R46.
Paul N, Joyce GF. PMID: 12546800.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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In search of an RNA replicase ribozyme. Chem Biol. 2003 Jan; 10(1):5-14.
McGinness KE, Joyce GF. PMID: 12573693.
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PubMed Mentions:
26 Fields:
Translation:
Cells
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A ribozyme composed of only two different nucleotides. Nature. 2002 Dec 19-26; 420(6917):841-4.
Reader JS, Joyce GF. PMID: 12490955.
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PubMed Mentions:
23 Fields:
Translation:
Cells
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Molecular evolution: booting up life. Nature. 2002 Nov 21; 420(6913):278-9.
Joyce GF. PMID: 12447426.
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PubMed Mentions:
11 Fields:
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RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. J Am Chem Soc. 2002 Oct 23; 124(42):12499-506.
Ordoukhanian P, Joyce GF. PMID: 12381192.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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A self-replicating ligase ribozyme. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12733-40.
Paul N, Joyce GF. PMID: 12239349; PMCID: PMC130529.
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PubMed Mentions:
54 Fields:
Translation:
Cells
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The antiquity of RNA-based evolution. Nature. 2002 Jul 11; 418(6894):214-21.
Joyce GF. PMID: 12110897.
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PubMed Mentions:
275 Fields:
Translation:
Cells
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Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. Chem Biol. 2002 May; 9(5):585-96.
McGinness KE, Wright MC, Joyce GF. PMID: 12031665.
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PubMed Mentions:
23 Fields:
Translation:
Cells
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RNA-catalyzed RNA ligation on an external RNA template. Chem Biol. 2002 Mar; 9(3):297-307.
McGinness KE, Joyce GF. PMID: 11927255.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Substitution of ribonucleotides in the T7 RNA polymerase promoter element. J Biol Chem. 2002 Jan 25; 277(4):2987-91.
McGinness KE, Joyce GF. PMID: 11704669.
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PubMed Mentions:
5 Fields:
Translation:
Cells