Gerald Joyce

Title(s)Adjunct Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Ligand-Dependent Exponential Amplification of RNA
    NIH R01GM065130Apr 1, 2002 - Nov 30, 2016
    Role: Principal Investigator
    CATALYTIC RNA AND DNA AS ANTIHIV 1 THERAPEUTIC AGENTS
    NIH R01AI030882Dec 1, 1990 - Mar 31, 2002
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA. J Am Chem Soc. 2021 11 17; 143(45):19160-19166. Bare GAL, Joyce GF. PMID: 34731573.
      View in: PubMed   Mentions:
    2. Witnessing the structural evolution of an RNA enzyme. Elife. 2021 09 09; 10. Portillo X, Huang YT, Breaker RR, Horning DP, Joyce GF. PMID: 34498588; PMCID: PMC8460264.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    3. Kinetic Effects of β,γ-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA. Biochemistry. 2021 01 12; 60(1):1-5. Setterholm NA, Haratipour P, Kashemirov BA, McKenna CE, Joyce GF. PMID: 33356161; PMCID: PMC8024617.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. RNA-Catalyzed Cross-Chiral Polymerization of RNA. J Am Chem Soc. 2020 09 09; 142(36):15331-15339. Tjhung KF, Sczepanski JT, Murtfeldt ER, Joyce GF. PMID: 32805113.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    5. Thermal Habitat for RNA Amplification and Accumulation. Phys Rev Lett. 2020 Jul 24; 125(4):048104. Salditt A, Keil LMR, Horning DP, Mast CB, Joyce GF, Braun D. PMID: 32794805.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    6. An RNA polymerase ribozyme that synthesizes its own ancestor. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):2906-2913. Tjhung KF, Shokhirev MN, Horning DP, Joyce GF. PMID: 31988127; PMCID: PMC7022166.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    7. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. ACS Synth Biol. 2019 05 17; 8(5):955-961. Horning DP, Bala S, Chaput JC, Joyce GF. PMID: 31042360; PMCID: PMC8111818.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    8. Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA. J Am Chem Soc. 2019 04 17; 141(15):6213-6223. Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. PMID: 30912655; PMCID: PMC6548421.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    9. 3'-End labeling of nucleic acids by a polymerase ribozyme. Nucleic Acids Res. 2018 09 28; 46(17):e103. Samanta B, Horning DP, Joyce GF. PMID: 29901762; PMCID: PMC6158495.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    10. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018 09 04; 10(9). Joyce GF, Szostak JW. PMID: 30181195; PMCID: PMC6120706.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    11. A reverse transcriptase ribozyme. Elife. 2017 09 26; 6. Samanta B, Joyce GF. PMID: 28949294; PMCID: PMC5665644.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    12. Real-Time Detection of a Self-Replicating RNA Enzyme. Molecules. 2016 Sep 30; 21(10). Olea C, Joyce GF. PMID: 27706059; PMCID: PMC5108293.
      View in: PubMed   Mentions: 4     Fields:    
    13. Amplification of RNA by an RNA polymerase ribozyme. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9786-91. Horning DP, Joyce GF. PMID: 27528667; PMCID: PMC5024611.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    14. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. J Am Chem Soc. 2015 Dec 30; 137(51):16032-7. Sczepanski JT, Joyce GF. PMID: 26652064; PMCID: PMC4703082.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Reflections of a Darwinian Engineer. J Mol Evol. 2015 Dec; 81(5-6):146-9. Joyce GF. PMID: 26597943; PMCID: PMC5257008.
      View in: PubMed   Mentions: 2     Fields:    
    16. An L-RNA Aptamer that Binds and Inhibits RNase. Chem Biol. 2015 Nov 19; 22(11):1437-1441. Olea C, Weidmann J, Dawson PE, Joyce GF. PMID: 26590636; PMCID: PMC4656138.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    17. Ligand-dependent exponential amplification of self-replicating RNA enzymes. Methods Enzymol. 2015; 550:23-39. Olea C, Joyce GF. PMID: 25605379; PMCID: PMC5103853.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. A cross-chiral RNA polymerase ribozyme. Nature. 2014 Nov 20; 515(7527):440-2. Sczepanski JT, Joyce GF. PMID: 25363769; PMCID: PMC4239201.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    19. The expanding view of RNA and DNA function. Chem Biol. 2014 Sep 18; 21(9):1059-65. Breaker RR, Joyce GF. PMID: 25237854; PMCID: PMC4171699.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    20. Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. J Mol Evol. 2014 Oct; 79(3-4):75-90. Petrie KL, Joyce GF. PMID: 25155818; PMCID: PMC4185262.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    21. Highly efficient self-replicating RNA enzymes. Chem Biol. 2014 Feb 20; 21(2):238-45. Robertson MP, Joyce GF. PMID: 24388759; PMCID: PMC3943892.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    22. Binding of a structured D-RNA molecule by an L-RNA aptamer. J Am Chem Soc. 2013 Sep 11; 135(36):13290-3. Sczepanski JT, Joyce GF. PMID: 23977945; PMCID: PMC3804424.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    23. Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. Biochemistry. 2013 Feb 19; 52(7):1227-35. Ferretti AC, Joyce GF. PMID: 23384307; PMCID: PMC3579227.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    24. Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. Chem Biol. 2012 Oct 26; 19(10):1324-32. Sczepanski JT, Joyce GF. PMID: 23102225; PMCID: PMC3483592.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    25. Bit by bit: the Darwinian basis of life. PLoS Biol. 2012; 10(5):e1001323. Joyce GF. PMID: 22589698; PMCID: PMC3348159.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    26. Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. J Am Chem Soc. 2012 May 16; 134(19):8050-3. Olea C, Horning DP, Joyce GF. PMID: 22551009; PMCID: PMC3357125.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    27. The origins of the RNA world. Cold Spring Harb Perspect Biol. 2012 May 01; 4(5). Robertson MP, Joyce GF. PMID: 20739415; PMCID: PMC3331698.
      View in: PubMed   Mentions: 125     Fields:    Translation:Cells
    28. Evolution. Toward an alternative biology. Science. 2012 Apr 20; 336(6079):307-8. Joyce GF. PMID: 22517850.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    29. An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. J Am Chem Soc. 2011 Mar 09; 133(9):3191-7. Lam BJ, Joyce GF. PMID: 21322594; PMCID: PMC3048896.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    30. Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. Nucleic Acids Res. 2010 Dec; 38(22):8095-104. Petrie KL, Joyce GF. PMID: 20693528; PMCID: PMC3001061.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    31. Microfluidic compartmentalized directed evolution. Chem Biol. 2010 Jul 30; 17(7):717-24. Paegel BM, Joyce GF. PMID: 20659684; PMCID: PMC2912841.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    32. Niche partitioning in the coevolution of 2 distinct RNA enzymes. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7780-5. Voytek SB, Joyce GF. PMID: 19416904; PMCID: PMC2683078.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    33. Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. Nat Biotechnol. 2009 Mar; 27(3):288-92. Lam BJ, Joyce GF. PMID: 19234448; PMCID: PMC2695811.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    34. Self-sustained replication of an RNA enzyme. Science. 2009 Feb 27; 323(5918):1229-32. Lincoln TA, Joyce GF. PMID: 19131595; PMCID: PMC2652413.
      View in: PubMed   Mentions: 183     Fields:    Translation:Cells
    35. Darwinian evolution on a chip. PLoS Biol. 2008 Apr 08; 6(4):e85. Paegel BM, Joyce GF. PMID: 18399721; PMCID: PMC2288630.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    36. Obituary: Leslie Orgel (1927-2007). Nature. 2007 Nov 29; 450(7170):627. Joyce GF. PMID: 18046392.
      View in: PubMed   Mentions:    Fields:    
    37. Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15288-93. Voytek SB, Joyce GF. PMID: 17878292; PMCID: PMC2000504.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    38. Structural biology. A glimpse of biology's first enzyme. Science. 2007 Mar 16; 315(5818):1507-8. Joyce GF. PMID: 17363651.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    39. Forty years of in vitro evolution. Angew Chem Int Ed Engl. 2007; 46(34):6420-36. Joyce GF. PMID: 17634987.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    40. Microfluidic serial dilution circuit. Anal Chem. 2006 Nov 01; 78(21):7522-7. Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF. PMID: 17073422; PMCID: PMC2566538.
      View in: PubMed   Mentions: 12     Fields:    
    41. Mutagenic PCR. CSH Protoc. 2006 Jun 01; 2006(1). Cadwell RC, Joyce GF. PMID: 22485544.
      View in: PubMed   Mentions: 3  
    42. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. Chem Biol. 2006 Mar; 13(3):329-38. Paul N, Springsteen G, Joyce GF. PMID: 16638538.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    43. A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. Angew Chem Int Ed Engl. 2005 Nov 25; 44(46):7580-3. Oberhuber M, Joyce GF. PMID: 16240312.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    44. The promise and peril of continuous in vitro evolution. J Mol Evol. 2005 Aug; 61(2):253-63. Johns GC, Joyce GF. PMID: 15999246.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    45. Minimal self-replicating systems. Curr Opin Chem Biol. 2004 Dec; 8(6):634-9. Paul N, Joyce GF. PMID: 15556408.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    46. Cross-catalytic replication of an RNA ligase ribozyme. Chem Biol. 2004 Nov; 11(11):1505-12. Kim DE, Joyce GF. PMID: 15556001.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    47. Selective derivatization and sequestration of ribose from a prebiotic mix. J Am Chem Soc. 2004 Aug 11; 126(31):9578-83. Springsteen G, Joyce GF. PMID: 15291561.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    48. A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature. 2004 Feb 12; 427(6975):618-21. Shih WM, Quispe JD, Joyce GF. PMID: 14961116.
      View in: PubMed   Mentions: 154     Fields:    Translation:Cells
    49. Directed evolution of nucleic acid enzymes. Annu Rev Biochem. 2004; 73:791-836. Joyce GF. PMID: 15189159.
      View in: PubMed   Mentions: 140     Fields:    
    50. Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. J Mol Evol. 2003 Sep; 57(3):292-8. Kühne H, Joyce GF. PMID: 14629039.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    51. A modular, bifunctional RNA that integrates itself into a target RNA. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9738-43. Kumar RM, Joyce GF. PMID: 12913125; PMCID: PMC187835.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    52. Perfectly complementary nucleic acid enzymes. J Mol Evol. 2003 Jun; 56(6):711-7. Kuhns ST, Joyce GF. PMID: 12911034.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    53. Self-replication. Curr Biol. 2003 Jan 21; 13(2):R46. Paul N, Joyce GF. PMID: 12546800.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    54. In search of an RNA replicase ribozyme. Chem Biol. 2003 Jan; 10(1):5-14. McGinness KE, Joyce GF. PMID: 12573693.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    55. A ribozyme composed of only two different nucleotides. Nature. 2002 Dec 19-26; 420(6917):841-4. Reader JS, Joyce GF. PMID: 12490955.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    56. Molecular evolution: booting up life. Nature. 2002 Nov 21; 420(6913):278-9. Joyce GF. PMID: 12447426.
      View in: PubMed   Mentions: 10     Fields:    
    57. RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. J Am Chem Soc. 2002 Oct 23; 124(42):12499-506. Ordoukhanian P, Joyce GF. PMID: 12381192.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    58. A self-replicating ligase ribozyme. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12733-40. Paul N, Joyce GF. PMID: 12239349; PMCID: PMC130529.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    59. The antiquity of RNA-based evolution. Nature. 2002 Jul 11; 418(6894):214-21. Joyce GF. PMID: 12110897.
      View in: PubMed   Mentions: 247     Fields:    Translation:Cells
    60. Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. Chem Biol. 2002 May; 9(5):585-96. McGinness KE, Wright MC, Joyce GF. PMID: 12031665.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    61. RNA-catalyzed RNA ligation on an external RNA template. Chem Biol. 2002 Mar; 9(3):297-307. McGinness KE, Joyce GF. PMID: 11927255.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    62. Substitution of ribonucleotides in the T7 RNA polymerase promoter element. J Biol Chem. 2002 Jan 25; 277(4):2987-91. McGinness KE, Joyce GF. PMID: 11704669.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
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