Gerald Joyce

Title(s)Adjunct Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Ligand-Dependent Exponential Amplification of RNA
    NIH R01GM065130Apr 1, 2002 - Nov 30, 2016
    Role: Principal Investigator
    CATALYTIC RNA AND DNA AS ANTIHIV 1 THERAPEUTIC AGENTS
    NIH R01AI030882Dec 1, 1990 - Mar 31, 2002
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. RNA-catalyzed evolution of catalytic RNA. Proc Natl Acad Sci U S A. 2024 Mar 12; 121(11):e2321592121. Papastavrou N, Horning DP, Joyce GF. PMID: 38437533; PMCID: PMC10945747.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    2. Correction to "Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA". J Am Chem Soc. 2024 Feb 07; 146(5):3564. Bare GAL, Joyce GF. PMID: 38266496.
      View in: PubMed   Mentions:    Fields:    
    3. RNA Polymerase Ribozyme That Recognizes the Template-Primer Complex through Tertiary Interactions. Biochemistry. 2023 06 20; 62(12):1916-1928. Kakoti A, Joyce GF. PMID: 37256719.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Discovery of small molecules that target a tertiary-structured RNA. Proc Natl Acad Sci U S A. 2022 11 29; 119(48):e2213117119. Menichelli E, Lam BJ, Wang Y, Wang VS, Shaffer J, Tjhung KF, Bursulaya B, Nguyen TN, Vo T, Alper PB, McAllister CS, Jones DH, Spraggon G, Michellys PY, Joslin J, Joyce GF, Rogers J. PMID: 36413497; PMCID: PMC9860313.
      View in: PubMed   Mentions: 6     Fields:    
    5. Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA. J Am Chem Soc. 2021 11 17; 143(45):19160-19166. Bare GAL, Joyce GF. PMID: 34731573.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    6. Witnessing the structural evolution of an RNA enzyme. Elife. 2021 09 09; 10. Portillo X, Huang YT, Breaker RR, Horning DP, Joyce GF. PMID: 34498588; PMCID: PMC8460264.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    7. Kinetic Effects of β,γ-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA. Biochemistry. 2021 01 12; 60(1):1-5. Setterholm NA, Haratipour P, Kashemirov BA, McKenna CE, Joyce GF. PMID: 33356161; PMCID: PMC8024617.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. RNA-Catalyzed Cross-Chiral Polymerization of RNA. J Am Chem Soc. 2020 09 09; 142(36):15331-15339. Tjhung KF, Sczepanski JT, Murtfeldt ER, Joyce GF. PMID: 32805113.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    9. Thermal Habitat for RNA Amplification and Accumulation. Phys Rev Lett. 2020 Jul 24; 125(4):048104. Salditt A, Keil LMR, Horning DP, Mast CB, Joyce GF, Braun D. PMID: 32794805.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    10. An RNA polymerase ribozyme that synthesizes its own ancestor. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):2906-2913. Tjhung KF, Shokhirev MN, Horning DP, Joyce GF. PMID: 31988127; PMCID: PMC7022166.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    11. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. ACS Synth Biol. 2019 05 17; 8(5):955-961. Horning DP, Bala S, Chaput JC, Joyce GF. PMID: 31042360; PMCID: PMC8111818.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    12. Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA. J Am Chem Soc. 2019 04 17; 141(15):6213-6223. Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. PMID: 30912655; PMCID: PMC6548421.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    13. 3'-End labeling of nucleic acids by a polymerase ribozyme. Nucleic Acids Res. 2018 09 28; 46(17):e103. Samanta B, Horning DP, Joyce GF. PMID: 29901762; PMCID: PMC6158495.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    14. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018 09 04; 10(9). Joyce GF, Szostak JW. PMID: 30181195; PMCID: PMC6120706.
      View in: PubMed   Mentions: 108     Fields:    Translation:Cells
    15. A reverse transcriptase ribozyme. Elife. 2017 09 26; 6. Samanta B, Joyce GF. PMID: 28949294; PMCID: PMC5665644.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    16. Real-Time Detection of a Self-Replicating RNA Enzyme. Molecules. 2016 Sep 30; 21(10). Olea C, Joyce GF. PMID: 27706059; PMCID: PMC5108293.
      View in: PubMed   Mentions: 5     Fields:    
    17. Amplification of RNA by an RNA polymerase ribozyme. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9786-91. Horning DP, Joyce GF. PMID: 27528667; PMCID: PMC5024611.
      View in: PubMed   Mentions: 94     Fields:    Translation:Cells
    18. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. J Am Chem Soc. 2015 Dec 30; 137(51):16032-7. Sczepanski JT, Joyce GF. PMID: 26652064; PMCID: PMC4703082.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. Reflections of a Darwinian Engineer. J Mol Evol. 2015 Dec; 81(5-6):146-9. Joyce GF. PMID: 26597943; PMCID: PMC5257008.
      View in: PubMed   Mentions: 2     Fields:    
    20. An L-RNA Aptamer that Binds and Inhibits RNase. Chem Biol. 2015 Nov 19; 22(11):1437-1441. Olea C, Weidmann J, Dawson PE, Joyce GF. PMID: 26590636; PMCID: PMC4656138.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    21. Ligand-dependent exponential amplification of self-replicating RNA enzymes. Methods Enzymol. 2015; 550:23-39. Olea C, Joyce GF. PMID: 25605379; PMCID: PMC5103853.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    22. A cross-chiral RNA polymerase ribozyme. Nature. 2014 Nov 20; 515(7527):440-2. Sczepanski JT, Joyce GF. PMID: 25363769; PMCID: PMC4239201.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    23. The expanding view of RNA and DNA function. Chem Biol. 2014 Sep 18; 21(9):1059-65. Breaker RR, Joyce GF. PMID: 25237854; PMCID: PMC4171699.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    24. Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. J Mol Evol. 2014 Oct; 79(3-4):75-90. Petrie KL, Joyce GF. PMID: 25155818; PMCID: PMC4185262.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    25. Highly efficient self-replicating RNA enzymes. Chem Biol. 2014 Feb 20; 21(2):238-45. Robertson MP, Joyce GF. PMID: 24388759; PMCID: PMC3943892.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    26. Binding of a structured D-RNA molecule by an L-RNA aptamer. J Am Chem Soc. 2013 Sep 11; 135(36):13290-3. Sczepanski JT, Joyce GF. PMID: 23977945; PMCID: PMC3804424.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    27. Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. Biochemistry. 2013 Feb 19; 52(7):1227-35. Ferretti AC, Joyce GF. PMID: 23384307; PMCID: PMC3579227.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    28. Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. Chem Biol. 2012 Oct 26; 19(10):1324-32. Sczepanski JT, Joyce GF. PMID: 23102225; PMCID: PMC3483592.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    29. Bit by bit: the Darwinian basis of life. PLoS Biol. 2012; 10(5):e1001323. Joyce GF. PMID: 22589698; PMCID: PMC3348159.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    30. Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. J Am Chem Soc. 2012 May 16; 134(19):8050-3. Olea C, Horning DP, Joyce GF. PMID: 22551009; PMCID: PMC3357125.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    31. The origins of the RNA world. Cold Spring Harb Perspect Biol. 2012 May 01; 4(5). Robertson MP, Joyce GF. PMID: 20739415; PMCID: PMC3331698.
      View in: PubMed   Mentions: 185     Fields:    Translation:Cells
    32. Evolution. Toward an alternative biology. Science. 2012 Apr 20; 336(6079):307-8. Joyce GF. PMID: 22517850.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    33. An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. J Am Chem Soc. 2011 Mar 09; 133(9):3191-7. Lam BJ, Joyce GF. PMID: 21322594; PMCID: PMC3048896.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    34. Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. Nucleic Acids Res. 2010 Dec; 38(22):8095-104. Petrie KL, Joyce GF. PMID: 20693528; PMCID: PMC3001061.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    35. Microfluidic compartmentalized directed evolution. Chem Biol. 2010 Jul 30; 17(7):717-24. Paegel BM, Joyce GF. PMID: 20659684; PMCID: PMC2912841.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    36. Niche partitioning in the coevolution of 2 distinct RNA enzymes. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7780-5. Voytek SB, Joyce GF. PMID: 19416904; PMCID: PMC2683078.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    37. Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. Nat Biotechnol. 2009 Mar; 27(3):288-92. Lam BJ, Joyce GF. PMID: 19234448; PMCID: PMC2695811.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    38. Self-sustained replication of an RNA enzyme. Science. 2009 Feb 27; 323(5918):1229-32. Lincoln TA, Joyce GF. PMID: 19131595; PMCID: PMC2652413.
      View in: PubMed   Mentions: 209     Fields:    Translation:Cells
    39. Darwinian evolution on a chip. PLoS Biol. 2008 Apr 08; 6(4):e85. Paegel BM, Joyce GF. PMID: 18399721; PMCID: PMC2288630.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    40. Obituary: Leslie Orgel (1927-2007). Nature. 2007 Nov 29; 450(7170):627. Joyce GF. PMID: 18046392.
      View in: PubMed   Mentions:    Fields:    
    41. Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15288-93. Voytek SB, Joyce GF. PMID: 17878292; PMCID: PMC2000504.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    42. Structural biology. A glimpse of biology's first enzyme. Science. 2007 Mar 16; 315(5818):1507-8. Joyce GF. PMID: 17363651.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    43. Forty years of in vitro evolution. Angew Chem Int Ed Engl. 2007; 46(34):6420-36. Joyce GF. PMID: 17634987.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    44. Microfluidic serial dilution circuit. Anal Chem. 2006 Nov 01; 78(21):7522-7. Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF. PMID: 17073422; PMCID: PMC2566538.
      View in: PubMed   Mentions: 13     Fields:    
    45. Mutagenic PCR. CSH Protoc. 2006 Jun 01; 2006(1). Cadwell RC, Joyce GF. PMID: 22485544.
      View in: PubMed   Mentions: 4  
    46. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. Chem Biol. 2006 Mar; 13(3):329-38. Paul N, Springsteen G, Joyce GF. PMID: 16638538.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    47. A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. Angew Chem Int Ed Engl. 2005 Nov 25; 44(46):7580-3. Oberhuber M, Joyce GF. PMID: 16240312.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    48. The promise and peril of continuous in vitro evolution. J Mol Evol. 2005 Aug; 61(2):253-63. Johns GC, Joyce GF. PMID: 15999246.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    49. Minimal self-replicating systems. Curr Opin Chem Biol. 2004 Dec; 8(6):634-9. Paul N, Joyce GF. PMID: 15556408.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    50. Cross-catalytic replication of an RNA ligase ribozyme. Chem Biol. 2004 Nov; 11(11):1505-12. Kim DE, Joyce GF. PMID: 15556001.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    51. Selective derivatization and sequestration of ribose from a prebiotic mix. J Am Chem Soc. 2004 Aug 11; 126(31):9578-83. Springsteen G, Joyce GF. PMID: 15291561.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    52. A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature. 2004 Feb 12; 427(6975):618-21. Shih WM, Quispe JD, Joyce GF. PMID: 14961116.
      View in: PubMed   Mentions: 184     Fields:    Translation:Cells
    53. Directed evolution of nucleic acid enzymes. Annu Rev Biochem. 2004; 73:791-836. Joyce GF. PMID: 15189159.
      View in: PubMed   Mentions: 141     Fields:    
    54. Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. J Mol Evol. 2003 Sep; 57(3):292-8. Kühne H, Joyce GF. PMID: 14629039.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    55. A modular, bifunctional RNA that integrates itself into a target RNA. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9738-43. Kumar RM, Joyce GF. PMID: 12913125; PMCID: PMC187835.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    56. Perfectly complementary nucleic acid enzymes. J Mol Evol. 2003 Jun; 56(6):711-7. Kuhns ST, Joyce GF. PMID: 12911034.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    57. Self-replication. Curr Biol. 2003 Jan 21; 13(2):R46. Paul N, Joyce GF. PMID: 12546800.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    58. In search of an RNA replicase ribozyme. Chem Biol. 2003 Jan; 10(1):5-14. McGinness KE, Joyce GF. PMID: 12573693.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    59. A ribozyme composed of only two different nucleotides. Nature. 2002 Dec 19-26; 420(6917):841-4. Reader JS, Joyce GF. PMID: 12490955.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    60. Molecular evolution: booting up life. Nature. 2002 Nov 21; 420(6913):278-9. Joyce GF. PMID: 12447426.
      View in: PubMed   Mentions: 11     Fields:    
    61. RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. J Am Chem Soc. 2002 Oct 23; 124(42):12499-506. Ordoukhanian P, Joyce GF. PMID: 12381192.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    62. A self-replicating ligase ribozyme. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12733-40. Paul N, Joyce GF. PMID: 12239349; PMCID: PMC130529.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    63. The antiquity of RNA-based evolution. Nature. 2002 Jul 11; 418(6894):214-21. Joyce GF. PMID: 12110897.
      View in: PubMed   Mentions: 286     Fields:    Translation:Cells
    64. Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. Chem Biol. 2002 May; 9(5):585-96. McGinness KE, Wright MC, Joyce GF. PMID: 12031665.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    65. RNA-catalyzed RNA ligation on an external RNA template. Chem Biol. 2002 Mar; 9(3):297-307. McGinness KE, Joyce GF. PMID: 11927255.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    66. Substitution of ribonucleotides in the T7 RNA polymerase promoter element. J Biol Chem. 2002 Jan 25; 277(4):2987-91. McGinness KE, Joyce GF. PMID: 11704669.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
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