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Gerald Joyce

Title(s)Adjunct Professor, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0636
La Jolla CA 92093
Phone858-453-4100
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    Ligand-Dependent Exponential Amplification of RNA
    NIH/NIGMS R01GM065130Apr 1, 2002 - Nov 30, 2015
    Role: Principal Investigator
    CATALYTIC RNA AND DNA AS ANTIHIV 1 THERAPEUTIC AGENTS
    NIH/NIAID R01AI030882Dec 1, 1990 - Nov 30, 1993
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An RNA polymerase ribozyme that synthesizes its own ancestor. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):2906-2913. Tjhung KF, Shokhirev MN, Horning DP, Joyce GF. PMID: 31988127.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. ACS Synth Biol. 2019 05 17; 8(5):955-961. Horning DP, Bala S, Chaput JC, Joyce GF. PMID: 31042360.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    3. Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA. J Am Chem Soc. 2019 04 17; 141(15):6213-6223. Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. PMID: 30912655.
      View in: PubMed   Mentions: 3     Fields:    
    4. 3'-End labeling of nucleic acids by a polymerase ribozyme. Nucleic Acids Res. 2018 09 28; 46(17):e103. Samanta B, Horning DP, Joyce GF. PMID: 29901762.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    5. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018 09 04; 10(9). Joyce GF, Szostak JW. PMID: 30181195.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    6. A reverse transcriptase ribozyme. Elife. 2017 09 26; 6. Samanta B, Joyce GF. PMID: 28949294.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    7. Real-Time Detection of a Self-Replicating RNA Enzyme. Molecules. 2016 Sep 30; 21(10). Olea C, Joyce GF. PMID: 27706059.
      View in: PubMed   Mentions: 2     Fields:    
    8. Amplification of RNA by an RNA polymerase ribozyme. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9786-91. Horning DP, Joyce GF. PMID: 27528667.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    9. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. J Am Chem Soc. 2015 Dec 30; 137(51):16032-7. Sczepanski JT, Joyce GF. PMID: 26652064.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Reflections of a Darwinian Engineer. J Mol Evol. 2015 Dec; 81(5-6):146-9. Joyce GF. PMID: 26597943.
      View in: PubMed   Mentions: 2     Fields:    
    11. An L-RNA Aptamer that Binds and Inhibits RNase. Chem Biol. 2015 Nov 19; 22(11):1437-1441. Olea C, Weidmann J, Dawson PE, Joyce GF. PMID: 26590636.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    12. Ligand-dependent exponential amplification of self-replicating RNA enzymes. Methods Enzymol. 2015; 550:23-39. Olea C, Joyce GF. PMID: 25605379.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. A cross-chiral RNA polymerase ribozyme. Nature. 2014 Nov 20; 515(7527):440-2. Sczepanski JT, Joyce GF. PMID: 25363769.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    14. The expanding view of RNA and DNA function. Chem Biol. 2014 Sep 18; 21(9):1059-65. Breaker RR, Joyce GF. PMID: 25237854.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    15. Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. J Mol Evol. 2014 Oct; 79(3-4):75-90. Petrie KL, Joyce GF. PMID: 25155818.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    16. Highly efficient self-replicating RNA enzymes. Chem Biol. 2014 Feb 20; 21(2):238-45. Robertson MP, Joyce GF. PMID: 24388759.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    17. Binding of a structured D-RNA molecule by an L-RNA aptamer. J Am Chem Soc. 2013 Sep 11; 135(36):13290-3. Sczepanski JT, Joyce GF. PMID: 23977945.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    18. Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. Biochemistry. 2013 Feb 19; 52(7):1227-35. Ferretti AC, Joyce GF. PMID: 23384307.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    19. Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. Chem Biol. 2012 Oct 26; 19(10):1324-32. Sczepanski JT, Joyce GF. PMID: 23102225.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    20. Bit by bit: the Darwinian basis of life. PLoS Biol. 2012; 10(5):e1001323. Joyce GF. PMID: 22589698.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    21. Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. J Am Chem Soc. 2012 May 16; 134(19):8050-3. Olea C, Horning DP, Joyce GF. PMID: 22551009.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    22. The origins of the RNA world. Cold Spring Harb Perspect Biol. 2012 May 01; 4(5). Robertson MP, Joyce GF. PMID: 20739415.
      View in: PubMed   Mentions: 76     Fields:    Translation:Cells
    23. Evolution. Toward an alternative biology. Science. 2012 Apr 20; 336(6079):307-8. Joyce GF. PMID: 22517850.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    24. An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. J Am Chem Soc. 2011 Mar 09; 133(9):3191-7. Lam BJ, Joyce GF. PMID: 21322594.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    25. Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. Nucleic Acids Res. 2010 Dec; 38(22):8095-104. Petrie KL, Joyce GF. PMID: 20693528.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    26. Microfluidic compartmentalized directed evolution. Chem Biol. 2010 Jul 30; 17(7):717-24. Paegel BM, Joyce GF. PMID: 20659684.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    27. Niche partitioning in the coevolution of 2 distinct RNA enzymes. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7780-5. Voytek SB, Joyce GF. PMID: 19416904.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    28. Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. Nat Biotechnol. 2009 Mar; 27(3):288-92. Lam BJ, Joyce GF. PMID: 19234448.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    29. Self-sustained replication of an RNA enzyme. Science. 2009 Feb 27; 323(5918):1229-32. Lincoln TA, Joyce GF. PMID: 19131595.
      View in: PubMed   Mentions: 157     Fields:    Translation:Cells
    30. Darwinian evolution on a chip. PLoS Biol. 2008 Apr 08; 6(4):e85. Paegel BM, Joyce GF. PMID: 18399721.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    31. Obituary: Leslie Orgel (1927-2007). Nature. 2007 Nov 29; 450(7170):627. Joyce GF. PMID: 18046392.
      View in: PubMed   Mentions:    Fields:    
    32. Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15288-93. Voytek SB, Joyce GF. PMID: 17878292.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    33. Structural biology. A glimpse of biology's first enzyme. Science. 2007 Mar 16; 315(5818):1507-8. Joyce GF. PMID: 17363651.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    34. Forty years of in vitro evolution. Angew Chem Int Ed Engl. 2007; 46(34):6420-36. Joyce GF. PMID: 17634987.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimals
    35. Microfluidic serial dilution circuit. Anal Chem. 2006 Nov 01; 78(21):7522-7. Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF. PMID: 17073422.
      View in: PubMed   Mentions: 12     Fields:    
    36. Mutagenic PCR. CSH Protoc. 2006 Jun 01; 2006(1). Cadwell RC, Joyce GF. PMID: 22485544.
      View in: PubMed   Mentions:
    37. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. Chem Biol. 2006 Mar; 13(3):329-38. Paul N, Springsteen G, Joyce GF. PMID: 16638538.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    38. A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. Angew Chem Int Ed Engl. 2005 Nov 25; 44(46):7580-3. Oberhuber M, Joyce GF. PMID: 16240312.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    39. The promise and peril of continuous in vitro evolution. J Mol Evol. 2005 Aug; 61(2):253-63. Johns GC, Joyce GF. PMID: 15999246.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    40. Minimal self-replicating systems. Curr Opin Chem Biol. 2004 Dec; 8(6):634-9. Paul N, Joyce GF. PMID: 15556408.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    41. Cross-catalytic replication of an RNA ligase ribozyme. Chem Biol. 2004 Nov; 11(11):1505-12. Kim DE, Joyce GF. PMID: 15556001.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    42. Selective derivatization and sequestration of ribose from a prebiotic mix. J Am Chem Soc. 2004 Aug 11; 126(31):9578-83. Springsteen G, Joyce GF. PMID: 15291561.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    43. A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature. 2004 Feb 12; 427(6975):618-21. Shih WM, Quispe JD, Joyce GF. PMID: 14961116.
      View in: PubMed   Mentions: 128     Fields:    Translation:Cells
    44. Directed evolution of nucleic acid enzymes. Annu Rev Biochem. 2004; 73:791-836. Joyce GF. PMID: 15189159.
      View in: PubMed   Mentions: 124     Fields:    
    45. Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. J Mol Evol. 2003 Sep; 57(3):292-8. Kühne H, Joyce GF. PMID: 14629039.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    46. A modular, bifunctional RNA that integrates itself into a target RNA. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9738-43. Kumar RM, Joyce GF. PMID: 12913125.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    47. Perfectly complementary nucleic acid enzymes. J Mol Evol. 2003 Jun; 56(6):711-7. Kuhns ST, Joyce GF. PMID: 12911034.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    48. Self-replication. Curr Biol. 2003 Jan 21; 13(2):R46. Paul N, Joyce GF. PMID: 12546800.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    49. In search of an RNA replicase ribozyme. Chem Biol. 2003 Jan; 10(1):5-14. McGinness KE, Joyce GF. PMID: 12573693.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    50. A ribozyme composed of only two different nucleotides. Nature. 2002 Dec 19-26; 420(6917):841-4. Reader JS, Joyce GF. PMID: 12490955.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    51. Molecular evolution: booting up life. Nature. 2002 Nov 21; 420(6913):278-9. Joyce GF. PMID: 12447426.
      View in: PubMed   Mentions: 8     Fields:    
    52. RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. J Am Chem Soc. 2002 Oct 23; 124(42):12499-506. Ordoukhanian P, Joyce GF. PMID: 12381192.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    53. A self-replicating ligase ribozyme. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12733-40. Paul N, Joyce GF. PMID: 12239349.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    54. The antiquity of RNA-based evolution. Nature. 2002 Jul 11; 418(6894):214-21. Joyce GF. PMID: 12110897.
      View in: PubMed   Mentions: 203     Fields:    Translation:Cells
    55. Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. Chem Biol. 2002 May; 9(5):585-96. McGinness KE, Wright MC, Joyce GF. PMID: 12031665.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    56. RNA-catalyzed RNA ligation on an external RNA template. Chem Biol. 2002 Mar; 9(3):297-307. McGinness KE, Joyce GF. PMID: 11927255.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    57. Substitution of ribonucleotides in the T7 RNA polymerase promoter element. J Biol Chem. 2002 Jan 25; 277(4):2987-91. McGinness KE, Joyce GF. PMID: 11704669.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
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