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Alexandra Sanchez Roige

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolHealth Sciences
ORCID ORCID Icon0000-0001-6137-5699 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University Autonomous of Barcelona, Barcelona (Spain)BSc08/2009Psychology
    University Autonomous of Barcelona, Barcelona (Spain)MSc08/2010Psychology
    University of Sussex, Sussex (UK)PhD12/2014Behavioral Neuroscience
    University of Sussex, Sussex (UK)Postdoctoral12/2015Behavioral Neuroscience
    University of California San Diego, San Diego (US)Postdoctoral03/2019Genetics
    University of California San Diego, San Diego (US)Assistant ProfessorCurrentGenetics

    Collapse Overview 
    Collapse Overview
    My work is focused on understanding causal factors contributing to substance use disorders, comorbid disorders and related traits, including impulsivity. In the past, I used behavioral and molecular analysis to address this question, with special emphasis on translational validity to human studies. I identified that high impulsivity, which is a maladaptive trait that is associated with substance use disorders, was both a cause and a consequence of human and mouse alcohol binge drinking. Over the past three years, my research has focused on the quantitative analysis of substance use disorders and externalizing traits in humans using genome-wide association methods (GWAS). This work was based on a collaboration with Dr. Palmer and the genetics company 23andMe, Inc. and used a cohort of ~25,000 individuals. We are currently expanding this work to include over 125,000 research participants.

    More recently, I have been recently appointed as an Assistant Professor at the Department of Psychiatry, University of California San Diego (UCSD). My newly formed lab uses genetic tools to unravel the biology of substance use disorders and comorbid psychopathology. Precisely, I use high-throughput phenotyping to identify individuals with substance use disorders phenotyped by using electronic health records, leveraging access to one of the largest biobanks in the US, BioVU, which contains data from over 2.8 million individuals. This represents a major paradigm shift in the field of psychiatric genetics, which could lead to major advances in gene discovery.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Abdellaoui A, Sanchez-Roige S, Sealock J, Treur JL, Dennis J, Fontanillas P, Elson S, Nivard MG, Ip HF, van der Zee M, Baselmans BML, Hottenga JJ, Willemsen G, Mosing M, Lu Y, Pedersen NL, Denys D, Amin N, M van Duijn C, Szilagyi I, Tiemeier H, Neumann A, Verweij KJH, Cacioppo S, Cacioppo JT, Davis LK, Palmer AA, Boomsma DI. Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness. Hum Mol Genet. 2019 Nov 15; 28(22):3853-3865. PMID: 31518406.
      View in: PubMed
    2. Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, de Wit H, Davis LK, MacKillop J, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability. Nat Neurosci. 2019 Jul; 22(7):1196. PMID: 31168101.
      View in: PubMed
    3. Gray JC, Sanchez-Roige S, de Wit H, MacKillop J, Palmer AA. Genomic basis of delayed reward discounting. Behav Processes. 2019 May; 162:157-161. PMID: 30876880.
      View in: PubMed
    4. Sanchez-Roige S, Fontanillas P, Elson SL, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2019 Mar; 22(3):503. PMID: 30622366.
      View in: PubMed
    5. Sanchez-Roige S, Palmer AA. Electronic Health Records Are the Next Frontier for the Genetics of Substance Use Disorders. Trends Genet. 2019 May; 35(5):317-318. PMID: 30797598.
      View in: PubMed
    6. Sanchez-Roige S, Fontanillas P, Elson SL, Gray JC, de Wit H, MacKillop J, Palmer AA. Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the CACNA1I and CADM2 genes. J Neurosci. 2019 Mar 27; 39(13):2562-2572. PMID: 30718321.
      View in: PubMed
    7. Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A, Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP. Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nat Genet. 2019 02; 51(2):245-257. PMID: 30643258.
      View in: PubMed
    8. Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018 12; 21(12):1656-1669. PMID: 30482948.
      View in: PubMed
    9. Sanchez-Roige S, Palmer AA, Fontanillas P, Elson SL, Adams MJ, Howard DM, Edenberg HJ, Davies G, Crist RC, Deary IJ, McIntosh AM, Clarke TK. Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. Am J Psychiatry. 2019 02 01; 176(2):107-118. PMID: 30336701.
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    10. MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA, de Wit H. Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. Exp Clin Psychopharmacol. 2019 Feb; 27(1):29-37. PMID: 30265060.
      View in: PubMed
    11. Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, de Wit H, Davis LK, MacKillop J, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci. 2018 09; 21(9):1161-1170. PMID: 30150663.
      View in: PubMed
    12. Sanchez-Roige S, Fontanillas P, Elson SL, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 Jul; 21(7):1018. PMID: 29752479.
      View in: PubMed
    13. Sanchez-Roige S, Gray JC, MacKillop J, Chen CH, Palmer AA. The genetics of human personality. Genes Brain Behav. 2018 03; 17(3):e12439. PMID: 29152902.
      View in: PubMed
    14. Sanchez-Roige S, Fontanillas P, Elson SL, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 01; 21(1):16-18. PMID: 29230059.
      View in: PubMed
    15. Sanchez-Roige S, Fontanillas P, Elson SL, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. Addict Biol. 2019 01; 24(1):121-131. PMID: 29058377.
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    16. Gao J, Davis LK, Hart AB, Sanchez-Roige S, Han L, Cacioppo JT, Palmer AA. Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation. Neuropsychopharmacology. 2017 Mar; 42(4):811-821. PMID: 27629369.
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    17. Sanchez-Roige S, Stephens DN, Duka T. Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol Intake. Alcohol Clin Exp Res. 2016 10; 40(10):2208-2217. PMID: 27565012.
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    18. Peña-Oliver Y, Carvalho FM, Sanchez-Roige S, Quinlan EB, Jia T, Walker-Tilley T, Rulten SL, Pearl FM, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Conrod PJ, Flor H, Gallinat J, Garavan H, Heinz A, Gowland P, Paillere Martinot ML, Paus T, Rietschel M, Robbins TW, Smolka MN, Schumann G, Stephens DN. Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse. Front Genet. 2016; 7:52. PMID: 27092175.
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    19. Lalanza JF, Sanchez-Roige S, Cigarroa I, Gagliano H, Fuentes S, Armario A, Capdevila L, Escorihuela RM. Long-term moderate treadmill exercise promotes stress-coping strategies in male and female rats. Sci Rep. 2015 Nov 05; 5:16166. PMID: 26538081.
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    20. Ripley TL, Sanchez-Roige S, Bullmore ET, Mugnaini M, Maltby K, Miller SR, Wille DR, Nathan P, Stephens DN. The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice. Psychopharmacology (Berl). 2015 Sep; 232(18):3431-41. PMID: 26141191.
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    21. Sanchez-Roige S, Ripley TL, Stephens DN. Alleviating waiting impulsivity and perseverative responding by µ-opioid receptor antagonism in two inbred mouse strains. Psychopharmacology (Berl). 2015 Apr; 232(8):1483-92. PMID: 25381183.
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    22. Sanchez-Roige S, Peña-Oliver Y, Ripley TL, Stephens DN. Repeated ethanol exposure during early and late adolescence: double dissociation of effects on waiting and choice impulsivity. Alcohol Clin Exp Res. 2014 Oct; 38(10):2579-89. PMID: 25346503.
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    23. Sanchez-Roige S, Lalanza JF, Alvarez-López MJ, Cosín-Tomás M, Griñan-Ferré C, Pallàs M, Kaliman P, Escorihuela RM. Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence. Age (Dordr). 2014; 36(5):9697. PMID: 25129573.
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    24. Bayod S, Guzmán-Brambila C, Sanchez-Roige S, Lalanza JF, Kaliman P, Ortuño-Sahagun D, Escorihuela RM, Pallàs M. Voluntary exercise promotes beneficial anti-aging mechanisms in SAMP8 female brain. J Mol Neurosci. 2015 Feb; 55(2):525-32. PMID: 25027560.
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    25. Sanchez-Roige S, Baro V, Trick L, Peña-Oliver Y, Stephens DN, Duka T. Exaggerated waiting impulsivity associated with human binge drinking, and high alcohol consumption in mice. Neuropsychopharmacology. 2014 Dec; 39(13):2919-27. PMID: 24947901.
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    26. Bayod S, Del Valle J, Pelegri C, Vilaplana J, Canudas AM, Camins A, Jimenez A, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Pallas M. Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues. J Physiol Pharmacol. 2014 Apr; 65(2):229-39. PMID: 24781732.
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    27. Cosín-Tomás M, Alvarez-López MJ, Sanchez-Roige S, Lalanza JF, Bayod S, Sanfeliu C, Pallàs M, Escorihuela RM, Kaliman P. Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise. Front Aging Neurosci. 2014; 6:51. PMID: 24688469.
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    28. Peña-Oliver Y, Sanchez-Roige S, Stephens DN, Ripley TL. Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task. Psychopharmacology (Berl). 2014 Jun; 231(12):2493-506. PMID: 24402137.
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    29. Bayod S, Mennella I, Menella I, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Camins A, Pallàs M, Canudas AM. Wnt pathway regulation by long-term moderate exercise in rat hippocampus. Brain Res. 2014 Jan 16; 1543:38-48. PMID: 24183784.
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    30. Alvarez-López MJ, Castro-Freire M, Cosín-Tomás M, Sanchez-Roige S, Lalanza JF, Del Valle J, Párrizas M, Camins A, Pallás M, Escorihuela RM, Kaliman P. Long-term exercise modulates hippocampal gene expression in senescent female mice. J Alzheimers Dis. 2013; 33(4):1177-90. PMID: 23168450.
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    31. Bayod S, Del Valle J, Lalanza JF, Sanchez-Roige S, de Luxán-Delgado B, Coto-Montes A, Canudas AM, Camins A, Escorihuela RM, Pallàs M. Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues. Exp Gerontol. 2012 Dec; 47(12):925-35. PMID: 22940286.
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    32. Lalanza JF, Sanchez-Roige S, Gagliano H, Fuentes S, Bayod S, Camins A, Pallàs M, Armario A, Escorihuela RM. Physiological and behavioural consequences of long-term moderate treadmill exercise. Psychoneuroendocrinology. 2012 Nov; 37(11):1745-54. PMID: 22472479.
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    33. Sanchez-Roige S, Peña-Oliver Y, Stephens DN. Measuring impulsivity in mice: the five-choice serial reaction time task. Psychopharmacology (Berl). 2012 Jan; 219(2):253-70. PMID: 22089700.
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    34. Bayod S, Del Valle J, Canudas AM, Lalanza JF, Sanchez-Roige S, Camins A, Escorihuela RM, Pallàs M. Long-term treadmill exercise induces neuroprotective molecular changes in rat brain. J Appl Physiol (1985). 2011 Nov; 111(5):1380-90. PMID: 21817108.
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