Sandra Sanchez Roige
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Title(s) | Assistant Adjunct Professor, Psychiatry |
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School | Vc-health Sciences-schools |
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Address | 9500 Gilman Drive # La Jolla CA 92093
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ORCID
.gif) | 0000-0001-6137-5699  |
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vCard | Download vCard |
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Biography University Autonomous of Barcelona, Barcelona (Spain) | BSc | 08/2009 | Psychology | University Autonomous of Barcelona, Barcelona (Spain) | MSc | 08/2010 | Psychology | University of Sussex, Sussex (UK) | PhD | 12/2014 | Neuroscience | University of Sussex, Sussex (UK) | Postdoctoral | 12/2015 | Neuroscience | University of California San Diego, San Diego (US) | Postdoctoral | 03/2019 | Genetics | University of California San Diego, San Diego (US) | Assistant Professor | Current | Genetics |
Overview My work is focused on understanding causal factors contributing to substance use disorders, comorbid disorders and related traits, including impulsivity. In the past, I used behavioral and molecular analysis to address this question, with special emphasis on translational validity to human studies. I identified that high impulsivity, which is a maladaptive trait that is associated with substance use disorders, was both a cause and a consequence of human and mouse alcohol binge drinking. Over the past three years, my research has focused on the quantitative analysis of substance use disorders and externalizing traits in humans using genome-wide association methods (GWAS). This work was based on a collaboration with Dr. Palmer and the genetics company 23andMe, Inc. and used a cohort of ~25,000 individuals. We are currently expanding this work to include over 125,000 research participants.
More recently, I have been recently appointed as an Assistant Professor at the Department of Psychiatry, University of California San Diego (UCSD). My newly formed lab uses genetic tools to unravel the biology of substance use disorders and comorbid psychopathology. Precisely, I use high-throughput phenotyping to identify individuals with substance use disorders phenotyped by using electronic health records, leveraging access to one of the largest biobanks in the US, BioVU, which contains data from over 2.8 million individuals. This represents a major paradigm shift in the field of psychiatric genetics, which could lead to major advances in gene discovery.
Research ORNG Applications Bibliographic
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Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness. Hum Mol Genet. 2019 11 15; 28(22):3853-3865.
Abdellaoui A, Sanchez-Roige S, Sealock J, Treur JL, Dennis J, Fontanillas P, Elson S, Nivard MG, Ip HF, van der Zee M, Baselmans BML, Hottenga JJ, Willemsen G, Mosing M, Lu Y, Pedersen NL, Denys D, Amin N, M van Duijn C, Szilagyi I, Tiemeier H, Neumann A, Verweij KJH, Cacioppo S, Cacioppo JT, Davis LK, Palmer AA, Boomsma DI. PMID: 31518406.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability. Nat Neurosci. 2019 Jul; 22(7):1196.
Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, de Wit H, Davis LK, MacKillop J, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. PMID: 31168101.
View in: PubMed Mentions: 1 Fields:
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Genomic basis of delayed reward discounting. Behav Processes. 2019 May; 162:157-161.
Gray JC, Sanchez-Roige S, de Wit H, MacKillop J, Palmer AA. PMID: 30876880.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimals
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Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2019 Mar; 22(3):503.
Sanchez-Roige S, Fontanillas P, Elson SL, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 30622366.
View in: PubMed Mentions: Fields:
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Electronic Health Records Are the Next Frontier for the Genetics of Substance Use Disorders. Trends Genet. 2019 05; 35(5):317-318.
Sanchez-Roige S, Palmer AA. PMID: 30797598.
View in: PubMed Mentions: 1 Fields: Translation: HumansPHPublic Health
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Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the CACNA1I and CADM2 genes. J Neurosci. 2019 03 27; 39(13):2562-2572.
Sanchez-Roige S, Fontanillas P, Elson SL, Gray JC, de Wit H, MacKillop J, Palmer AA. PMID: 30718321.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nat Genet. 2019 02; 51(2):245-257.
Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A, Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP. PMID: 30643258.
View in: PubMed Mentions: 36 Fields: Translation: Humans
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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018 12; 21(12):1656-1669.
Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A. PMID: 30482948.
View in: PubMed Mentions: 55 Fields: Translation: Humans
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Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. Am J Psychiatry. 2019 02 01; 176(2):107-118.
Sanchez-Roige S, Palmer AA, Fontanillas P, Elson SL, Adams MJ, Howard DM, Edenberg HJ, Davies G, Crist RC, Deary IJ, McIntosh AM, Clarke TK. PMID: 30336701.
View in: PubMed Mentions: 33 Fields: Translation: Humans
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Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. Exp Clin Psychopharmacol. 2019 Feb; 27(1):29-37.
MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA, de Wit H. PMID: 30265060.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci. 2018 09; 21(9):1161-1170.
Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, de Wit H, Davis LK, MacKillop J, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. PMID: 30150663.
View in: PubMed Mentions: 33 Fields: Translation: Humans
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Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 Jul; 21(7):1018.
Sanchez-Roige S, Fontanillas P, Elson SL, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 29752479.
View in: PubMed Mentions: Fields:
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The genetics of human personality. Genes Brain Behav. 2018 03; 17(3):e12439.
Sanchez-Roige S, Gray JC, MacKillop J, Chen CH, Palmer AA. PMID: 29152902.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 01; 21(1):16-18.
Sanchez-Roige S, Fontanillas P, Elson SL, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 29230059.
View in: PubMed Mentions: 19 Fields: Translation: Humans
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Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. Addict Biol. 2019 01; 24(1):121-131.
Sanchez-Roige S, Fontanillas P, Elson SL, , Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 29058377.
View in: PubMed Mentions: 22 Fields: Translation: HumansPHPublic Health
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Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation. Neuropsychopharmacology. 2017 Mar; 42(4):811-821.
Gao J, Davis LK, Hart AB, Sanchez-Roige S, Han L, Cacioppo JT, Palmer AA. PMID: 27629369.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol Intake. Alcohol Clin Exp Res. 2016 10; 40(10):2208-2217.
Sanchez-Roige S, Stephens DN, Duka T. PMID: 27565012.
View in: PubMed Mentions: 8 Fields: Translation: Humans
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Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse. Front Genet. 2016; 7:52.
Peña-Oliver Y, Carvalho FM, Sanchez-Roige S, Quinlan EB, Jia T, Walker-Tilley T, Rulten SL, Pearl FM, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Conrod PJ, Flor H, Gallinat J, Garavan H, Heinz A, Gowland P, Paillere Martinot ML, Paus T, Rietschel M, Robbins TW, Smolka MN, Schumann G, Stephens DN, . PMID: 27092175.
View in: PubMed Mentions:
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Long-term moderate treadmill exercise promotes stress-coping strategies in male and female rats. Sci Rep. 2015 Nov 05; 5:16166.
Lalanza JF, Sanchez-Roige S, Cigarroa I, Gagliano H, Fuentes S, Armario A, Capdevila L, Escorihuela RM. PMID: 26538081.
View in: PubMed Mentions: 10 Fields: Translation: Animals
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The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice. Psychopharmacology (Berl). 2015 Sep; 232(18):3431-41.
Ripley TL, Sanchez-Roige S, Bullmore ET, Mugnaini M, Maltby K, Miller SR, Wille DR, Nathan P, Stephens DN. PMID: 26141191.
View in: PubMed Mentions: 7 Fields: Translation: Animals
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Alleviating waiting impulsivity and perseverative responding by µ-opioid receptor antagonism in two inbred mouse strains. Psychopharmacology (Berl). 2015 Apr; 232(8):1483-92.
Sanchez-Roige S, Ripley TL, Stephens DN. PMID: 25381183.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimals
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Repeated ethanol exposure during early and late adolescence: double dissociation of effects on waiting and choice impulsivity. Alcohol Clin Exp Res. 2014 Oct; 38(10):2579-89.
Sanchez-Roige S, Peña-Oliver Y, Ripley TL, Stephens DN. PMID: 25346503.
View in: PubMed Mentions: 12 Fields: Translation: Animals
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Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence. Age (Dordr). 2014; 36(5):9697.
Sanchez-Roige S, Lalanza JF, Alvarez-López MJ, Cosín-Tomás M, Griñan-Ferré C, Pallàs M, Kaliman P, Escorihuela RM. PMID: 25129573.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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Voluntary exercise promotes beneficial anti-aging mechanisms in SAMP8 female brain. J Mol Neurosci. 2015 Feb; 55(2):525-32.
Bayod S, Guzmán-Brambila C, Sanchez-Roige S, Lalanza JF, Kaliman P, Ortuño-Sahagun D, Escorihuela RM, Pallàs M. PMID: 25027560.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Exaggerated waiting impulsivity associated with human binge drinking, and high alcohol consumption in mice. Neuropsychopharmacology. 2014 Dec; 39(13):2919-27.
Sanchez-Roige S, Baro V, Trick L, Peña-Oliver Y, Stephens DN, Duka T. PMID: 24947901.
View in: PubMed Mentions: 31 Fields: Translation: HumansAnimals
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Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues. J Physiol Pharmacol. 2014 Apr; 65(2):229-39.
Bayod S, Del Valle J, Pelegri C, Vilaplana J, Canudas AM, Camins A, Jimenez A, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Pallas M. PMID: 24781732.
View in: PubMed Mentions: 9 Fields: Translation: Animals
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Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise. Front Aging Neurosci. 2014; 6:51.
Cosín-Tomás M, Alvarez-López MJ, Sanchez-Roige S, Lalanza JF, Bayod S, Sanfeliu C, Pallàs M, Escorihuela RM, Kaliman P. PMID: 24688469.
View in: PubMed Mentions:
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Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task. Psychopharmacology (Berl). 2014 Jun; 231(12):2493-506.
Peña-Oliver Y, Sanchez-Roige S, Stephens DN, Ripley TL. PMID: 24402137.
View in: PubMed Mentions: 12 Fields: Translation: Animals
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Wnt pathway regulation by long-term moderate exercise in rat hippocampus. Brain Res. 2014 Jan 16; 1543:38-48.
Bayod S, Mennella I, Menella I, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Camins A, Pallàs M, Canudas AM. PMID: 24183784.
View in: PubMed Mentions: 21 Fields: Translation: AnimalsCells
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Long-term exercise modulates hippocampal gene expression in senescent female mice. J Alzheimers Dis. 2013; 33(4):1177-90.
Alvarez-López MJ, Castro-Freire M, Cosín-Tomás M, Sanchez-Roige S, Lalanza JF, Del Valle J, Párrizas M, Camins A, Pallás M, Escorihuela RM, Kaliman P. PMID: 23168450.
View in: PubMed Mentions: 15 Fields: Translation: Animals
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Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues. Exp Gerontol. 2012 Dec; 47(12):925-35.
Bayod S, Del Valle J, Lalanza JF, Sanchez-Roige S, de Luxán-Delgado B, Coto-Montes A, Canudas AM, Camins A, Escorihuela RM, Pallàs M. PMID: 22940286.
View in: PubMed Mentions: 13 Fields: Translation: AnimalsCells
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Physiological and behavioural consequences of long-term moderate treadmill exercise. Psychoneuroendocrinology. 2012 Nov; 37(11):1745-54.
Lalanza JF, Sanchez-Roige S, Gagliano H, Fuentes S, Bayod S, Camins A, Pallàs M, Armario A, Escorihuela RM. PMID: 22472479.
View in: PubMed Mentions: 6 Fields: Translation: Animals
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Measuring impulsivity in mice: the five-choice serial reaction time task. Psychopharmacology (Berl). 2012 Jan; 219(2):253-70.
Sanchez-Roige S, Peña-Oliver Y, Stephens DN. PMID: 22089700.
View in: PubMed Mentions: 17 Fields: Translation: AnimalsCells
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Long-term treadmill exercise induces neuroprotective molecular changes in rat brain. J Appl Physiol (1985). 2011 Nov; 111(5):1380-90.
Bayod S, Del Valle J, Canudas AM, Lalanza JF, Sanchez-Roige S, Camins A, Escorihuela RM, Pallàs M. PMID: 21817108.
View in: PubMed Mentions: 20 Fields: Translation: AnimalsCells
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Year | Publications |
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2011 | 2 | 2012 | 2 | 2013 | 2 | 2014 | 8 | 2015 | 2 | 2016 | 3 | 2017 | 3 | 2018 | 5 | 2019 | 7 |
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