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Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment. Am J Psychiatry. 2025 Oct 29; appiajp20240382.
Mallard TT, Tubbs JD, Jennings M, Zhang Y, Gustavson DE, Grotzinger AD, Westwater ML, Williams CM, Fortgang RG, 23andMe Research Team, Elson SL, Fontanillas P, Davis LK, Raznahan A, Tucker-Drob EM, Choi KW, Ge T, Smoller JW, Palmer AA, Sanchez-Roige S. PMID: 41152253.
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Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals. Mol Psychiatry. 2025 Oct 13.
Thorpe HHA, Fontanillas P, Meredith JJ, Jennings MV, Cupertino RB, Pakala SR, 23andMe Research Team, Elson SL, Khokhar JY, Davis LK, Johnson EC, Palmer AA, Sanchez-Roige S. PMID: 41077612.
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Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. Psychol Med. 2025 Aug 20; 55:e234.
Johnson EC, Lai D, Balbona JV, Miller AP, Hatoum AS, Deak JD, Jennings M, Baranger DAA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SMC, Adhikari K, Docherty AR, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries PW, Korhonen T, Morrison CL, Nunez YZ, Palviainen T, Su MH, Romero Villela PN, Wetherill L, Willoughby EA, Zellers SM, Bierut LJ, Buchwald J, Copeland WE, Corley RP, Friedman NP, Foroud TM, Gillespie NA, Gizer IR, Heath AC, Hickie IB, Kaprio J, Keller MC, Lee JJ, Lind P, Madden PA, Maes HHM, Martin NG, McGue M, Medland SE, Nelson EC, Pearson J, Porjesz B, Stallings MC, Vrieze S, Wilhelmson KC, Kranzler HR, Walters RK, Polimanti R, Malison R, Zhou H, Stefansson K, Sanchez-Roige S, Potenza M, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg HJ, Gelernter J, Agrawal A. PMID: 40831304; PMCID: PMC12360691.
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Humans
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Aberrant recursive splicing in a human disease locus. bioRxiv. 2025 Aug 15.
Boone PM, Harripaul R, Yadav R, Grzybowski M, Hanafy MK, Lee AC, Choi EY, Collins RL, Polesskaya O, Makhortova N, Larson MO, Kayir H, Wang Y, Avila RA, Frie JA, Eed A, Albeely AM, Venmuri S, Ayoub SM, Lemanski JM, Ben-Isvy D, Zhao X, Sanchis-Juan A, Handley M, Erdin S, de Esch C, Mohajeri K, Chen C, Tovar PG, Salani M, Oliveira MM, Tai DJC, Currall B, McGraw C, Slaughenhaupt S, Doan R, Gao D, Gusella JF, Sanchez-Roige S, Young J, Khokar J, Geurts AM, Palmer AA, Talkowski ME. PMID: 40919386; PMCID: PMC12413155.
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Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders. medRxiv. 2025 Aug 12.
Streit F, Awasthi S, Hall AS, Braun A, Niarchou M, Marouli E, Babajide O, Frank J, Zillich L, Callies CM, Avetyan D, Zillich E, Naamanka J, Gonzalez J, Harder A, Lu Y, Aherrahrou Z, Ahmad ZU, Ask H, Batzler A, Benros ME, Brand-de Wilde OM, Brunak S, Bruun MT, Christoffersen LA, Colodro-Conde L, Coombes BJ, Corfield EC, Dahmen N, Didriksen M, Dinh KM, Djurovic S, Dowsett J, Drange OK, Dukal H, Edelmann S, Erikstrup C, Espinola MK, Fassbinder E, Faucon A, de Sá DSF, Foo JC, Gilles M, Gutiérrez-Zotes A, Hansen TF, Haraldsson M, Harper RP, Havdahl A, Heilbronner U, Herms S, Hjalgrim H, Hübel C, Jacob GA, Aagaard B, Jorgensen A, Jungkunz M, Kleindienst N, Knoblich N, Koglin S, Kraft J, Krebs K, Lee CW, Lin Y, Lis S, Lisoway A, Malogiannis IA, Martinsen A, Maslahati T, Merz K, Meyer-Lindenberg A, Mikkelsen S, Mikkelsen C, Mobascher A, Muntané G, Oddsson A, Ostrowski SR, Palviainen T, Pedersen OB, Pedersen G, Quinn L, Reinhard MA, Ruths FA, Schott BH, Schredl M, Schwarz E, Schwarze CE, Schwinn M, Send T, Sigurdsson E, Simon-Keller K, Skuladottir AT, Soler J, Sonley A, Sørensen E, Stefansson H, Straub P, Suvisaari J, Tesli M, Træholt J, Ullum H, Völker MP, Walters GB, Wang R, Witt CC, Zarbock G, Zill P, Zwart JA, DBDS Genomic Consortium, Estonian Biobank Research Team, GLAD Study, HUNT All-In Psychiatry, Andreassen OA, Arntz A, Biernacka JM, Bohus M, Breen G, Chapman AL, Cichon S, Davis LK, Deuschle M, Euler S, Herpertz SC, Hummelen B, Jobst A, Kaprio J, Kennedy JL, Lehto K, Lieb K, Martorell L, McMain S, Musil R, Nieratschker V, Nöthen MM, Padberg F, Palotie A, Pascual JC, Perroud N, Ramos-Quiroga JA, Reichborn-Kjennerud T, Ribases M, Roepke S, Rujescu D, Sanchez-Roige S, Schilling C, Schmahl C, Stefansson K, Thorgeirsson TE, Turecki G, Vilella E, Werge T, Winsvold BS, Wrege J, Rietschel M, Ripke S, Witt SH. PMID: 40832388; PMCID: PMC12363718.
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Genome-Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study. Genes Brain Behav. 2025 Aug; 24(4):e70033.
Deng WQ, Elsayed M, Belisario KL, Sanchez-Roige S, Palmer AA, MacKillop J. PMID: 40847891; PMCID: PMC12374252.
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Humans
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Multivariate genetic of 2.2 million individuals demonstrate genetic influences on substance use disorders operate via behavioral disinhibition and substance-specific risk. medRxiv. 2025 Aug 01.
Poore HE, Chatzinakos C, Leger B, Gonzalez J, Mallard TT, Sanchez-Roige S, Aliev F, Hatoum A, COGA Collaborators, Waldman ID, Palmer AA, Harden KP, Dick DM, Barr PB. PMID: 39649581; PMCID: PMC11623735.
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A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits. medRxiv. 2025 Jul 16.
Shanta O, Klein M, Sacks M, MacDonald JR, Maihofer A, Ahangari M, Engchuan W, Thiruvahindrapuram B, Guevara J, Hong O, Huguet G, Sønderby I, Kalyuzhny M, Adams MJ, Adolfsson R, Agartz I, Aiello AE, Alda M, Allardyce J, Amstadter AB, Andlauer TFM, Andreassen OA, Artigas MS, Austin SB, Ayub M, Baker DG, Bass N, Baune BT, Bayas M, Berger K, Biernacka JM, Bigdeli T, Bisson JI, Blackwood D, Boks M, Braff D, Bramon E, Breen G, Brueckl T, Bryant RA, Bulik CM, Buxbaum J, Cairns MJ, Caldas-de-Almeida JM, Campbell M, Campion D, Carr VJ, Castelao E, Chaumette B, Cichon S, Cohen D, Corvin A, Craddock N, Crosbie J, Czamara D, Dannlowski U, Degenhardt F, Delahanty DL, Dempfle A, Desachy G, Di Florio A, Dickerson FB, Djurovic S, Domschke K, Douglas L, Drange OK, Duncan LE, Edenberg HJ, Esko T, Faraone S, Feeny NC, Forstner AJ, Franke B, Frye M, Fu DJ, Fullerton JM, Gareeva A, Garvert L, Gatt JM, Gejman P, Geschwind DH, Giegling I, Glatt SJ, Glessner J, Goes FS, Gordon-Smith K, Grabe H, Green MJ, Green MF, Greenwood T, Grigoroiu-Serbanescu M, Gur RE, Gur RC, Guzman-Parra J, Haavik J, Hahn T, Hakonarson H, Hallmayer J, Hamshere ML, Hartmann AM, Hassan A, Hayward C, Hebebrand J, Hemmings SMJ, Herms S, Herrera-Rivero M, Hinney A, Homuth G, Ingason A, Ito LT, Iwata N, Jones I, Jones LA, Jonsson L, Jönsson EG, Kahn RS, Karlsson R, Kaufman ML, Kelsoe JR, Kennedy JL, King A, Kircher T, Kirov G, Knappskog P, Knowles JA, Kobayashi N, Koenen KC, Konte B, Korgaonkar M, Kowalec K, Krebs MO, Landén M, Laurent-Levinson C, Lebois LA, Levinson D, Lewis C, Li Q, Liberzon I, Light G, Loo SK, Lu Y, Lucae S, Marmar C, Martin NG, Mayoral F, McIntosh AM, McLaughlin KA, McLean SA, McQuillin A, Medland SE, Meyer-Lindenberg A, Milanova V, Mitchell PB, Molina E, Mowry B, Muller-Myhsok B, Mullins N, Murray R, Nöthen MM, Nurnberger JI, O'Connell KS, Ophoff RA, Orcutt HK, Owen MJ, Palotie A, Pato C, Pato M, Pawlak J, Peters T, Petryshen TL, Pistis G, Potash JB, Powell J, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ressler KJ, Ribasés M, Rietschel M, Risbrough VB, Rivera M, Rothbaum AO, Rothbaum BO, Rujescu D, Saito T, Sanders AR, Schachar RJ, Schofield PR, Schulte EC, Schulze TG, Scott LJ, Seedat S, Sheerin C, Shi J, Sklar P, Smalley S, Smeland OB, Smoller JW, Sonuga-Barke E, Clair DS, Steen NE, Stein D, Stein F, Stein MB, Streit F, Swerdlow N, Thibaut F, Thygesen JH, Timerbulatov I, Toma C, Trapido E, Tremblay M, Tsuang MT, Uddin M, Vawter MP, Vincent JB, Völzke H, Walters JT, Weickert CS, Weiss LA, Weissman MM, Werge T, Witt SH, Xavier M, Yolken R, Young RM, Zayats T, Zoellner LA, AGP Consortium, PEIC Psychosis Endophenotypes International Consortium, ADHD Working Group of the Psychiatric Genomics Consortium, Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, PTSD Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, CNV Working Group of the Psychiatric Genomics Consortium, Kendall K, Riley B, et al. PMID: 40791719; PMCID: PMC12338896.
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Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects. medRxiv. 2025 Jul 16.
Engchuan W, Shanta O, Kumar K, MacDonald JR, Thiruvahindrapuram B, Hamdan O, Klein M, Maihofer A, Guevara J, Hong O, Huguet G, Sacks M, Ahangari M, Feitosa RMMW, Han K, Mendes M, Zhou X, Bautista NX, Pellecchia G, Wang Z, Merico D, Yuen RKC, Trost B, Sønderby I, Adams MJ, Adolfsson R, Agartz I, Aiello AE, Alda M, Allardyce J, Amstadter AB, Andlauer TFM, Andreassen OA, Artigas MS, Austin SB, Ayub M, Baker DG, Bass N, Baune BT, Bayas M, Berger K, Biernacka JM, Bigdeli T, Bisson JI, Blackwood D, Boks M, Braff D, Bramon E, Breen G, Brueckl T, Bryant RA, Bulik CM, Buxbaum J, Cairns MJ, Caldas-de-Almeida JM, Campbell M, Campion D, Carr VJ, Castelao E, Chaumette B, Cichon S, Cohen D, Corvin A, Craddock N, Crosbie J, Czamara D, Dannlowski U, Degenhardt F, Delahanty DL, Dempfle A, Desachy G, Di Florio A, Dickerson FB, Djurovic S, Domschke K, Douglas L, Drange OK, Duncan LE, Edenberg HJ, Esko T, Faraone S, Feeny NC, Forstner AJ, Franke B, Frye M, Fu DJ, Fullerton JM, Gareeva A, Garvert L, Gatt JM, Gejman P, Geschwind DH, Giegling I, Glatt SJ, Glessner J, Goes FS, Gordon-Smith K, Grabe H, Green MJ, Green MF, Greenwood T, Grigoroiu-Serbanescu M, Gur RE, Gur RC, Guzman-Parra J, Haavik J, Hahn T, Hakonarson H, Hallmayer J, Hamshere ML, Hartmann AM, Hassan A, Hayward C, Hebebrand J, Hemmings SMJ, Herms S, Herrera-Rivero M, Hinney A, Homuth G, Ingason A, Ito LT, Iwata N, Jones I, Jones LA, Jonsson L, Jönsson EG, Kahn RS, Karlsson R, Kaufman ML, Kelsoe JR, Kennedy JL, King A, Kircher T, Kirov G, Knappskog P, Knowles JA, Kobayashi N, Koenen KC, Konte B, Korgaonkar M, Kowalec K, Krebs MO, Landén M, Laurent-Levinson C, Lebois LA, Levinson D, Lewis C, Li Q, Liberzon I, Light G, Loo SK, Lu Y, Lucae S, Marmar C, Martin NG, Mayoral F, McIntosh AM, McLaughlin KA, McLean SA, McQuillin A, Medland SE, Meyer-Lindenberg A, Milanova V, Mitchell PB, Molina E, Mowry B, Muller-Myhsok B, Mullins N, Murray R, Nöthen MM, Nurnberger JI, O'Connell KS, Ophoff RA, Orcutt HK, Owen MJ, Palotie A, Pato C, Pato M, Pawlak J, Peters T, Petryshen TL, Pistis G, Potash JB, Powell J, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ressler KJ, Ribasés M, Rietschel M, Risbrough VB, Rivera M, Rothbaum AO, Rothbaum BO, Rujescu D, Saito T, Sanders AR, Schachar RJ, Schofield PR, Schulte EC, Schulze TG, Scott LJ, Seedat S, Sheerin C, Shi J, Sklar P, Smalley S, Smeland OB, Smoller JW, Sonuga-Barke E, Clair DS, Steen NE, Stein D, Stein F, Stein MB, Streit F, Swerdlow N, Thibaut F, Thygesen JH, Timerbulatov I, Toma C, Trapido E, Tremblay M, Tsuang MT, Uddin M, Vawter MP, Vincent JB, Völzke H, Walters JT, Weickert CS, Weiss LA, Weissman MM, Werge T, Witt SH, Xavier M, Yolken R, Young RM, Zayats T, Zoellner LA, AGP Consortium, PEIC Psychosis Endophenotypes International Consortium, ADHD Working Group of the Psychiatric Genomics Consortium, Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the P, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, PTSD Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, CNV Working Group of the Psychiatric Genomics Consortium, et al. PMID: 40791676; PMCID: PMC12338884.
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Genomic structural equation study reveals links between anorexia nervosa and delay discounting and lack of perseverance but not other facets of impulsivity. Front Psychiatry. 2025; 16:1613776.
Bianchi SB, Vilar-Ribó L, Palmer AA, Gustavson DE, Sanchez-Roige S. PMID: 40687276; PMCID: PMC12271091.
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Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development. bioRxiv. 2025 Jun 16.
Shishikura M, Liu L, Yu E, Zhu R, Vilar-Ribó L, Cupertino RB, Palmer AA, Sanchez-Roige S, Vainik U, Morys F, Gan-Or Z, Misic B, Dagher A. PMID: 40502124; PMCID: PMC12157643.
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Automating the Addiction Behaviors Checklist for Problematic Opioid Use Identification. JAMA Psychiatry. 2025 Jun 01; 82(6):591-598.
Chatham AH, Bradley ED, Troiani V, Beiler DL, Christy P, Schirle L, Sanchez-Roige S, Samuels DC, Jeffery AD. PMID: 40202749; PMCID: PMC11983290.
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Humans
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Investigating the Polygenic Relationship Between Cannabis Use and Schizophrenia in the All of Us Research Program. medRxiv. 2025 May 21.
Austin-Zimmerman I, Thorpe HH, Meredith JJ, Khokhar J, Ge T, Di Forti M, Agrawal A, Johnson EC, Sanchez-Roige S. PMID: 40475137; PMCID: PMC12140517.
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Prescription Opioid Medication Survey: A Tool to Collect Deep Phenotypic Data on the Multifactorial Pathways to Opioid Use Disorder in Clinical and Population-Based Cohorts. Complex Psychiatry. 2025 Jan-Dec; 11(1):72-93.
Courchesne-Krak NS, Chandrasekaran AR, Gonzalez J, Bianchi SB, Tran V, Johnson EO, Troiani V, Hettema JM, Stein MB, Coon H, Docherty AR, Berretini WH, MacKillop J, de Wit H, Marienfeld C, Palmer AA, Sanchez-Roige S. PMID: 40621581; PMCID: PMC12226013.
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Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries. Biol Psychiatry. 2025 May 08.
Khan Y, Davis CN, Jinwala Z, Feuer KL, Toikumo S, Hartwell EE, Sanchez-Roige S, Peterson RE, Hatoum AS, Kranzler HR, Kember RL. PMID: 40345609.
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Gene discovery and pleiotropic architecture of chronic pain in a genome-wide association study of >1.2 million individuals. Res Sq. 2025 Apr 10.
Toikumo S, Toikumo S, Davis C, Davis C, Jinwala Z, Jinwala Z, Khan Y, Khan Y, Jennings M, Jennings M, Davis L, Davis L, Sanchez-Roige S, Sanchez-Roige S, Kember RL, Kember RL, Kranzler HR, Kranzler HR. PMID: 40297705; PMCID: PMC12036444.
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Psychiatric genetics in the diverse landscape of Latin American populations. Nat Genet. 2025 May; 57(5):1074-1088.
Bruxel EM, Rovaris DL, Belangero SI, Chavarría-Soley G, Cuellar-Barboza AB, Martínez-Magaña JJ, Nagamatsu ST, Nievergelt CM, Núñez-Ríos DL, Ota VK, Peterson RE, Sloofman LG, Adams AM, Albino E, Alvarado AT, Andrade-Brito D, Arguello-Pascualli PY, Bandeira CE, Bau CHD, Bulik CM, Buxbaum JD, Cappi C, Corral-Frias NS, Corrales A, Corsi-Zuelli F, Crowley JJ, Cupertino RB, da Silva BS, De Almeida SS, De la Hoz JF, Forero DA, Fries GR, Gelernter J, González-Giraldo Y, Grevet EH, Grice DE, Hernández-Garayua A, Hettema JM, Ibáñez A, Ionita-Laza I, Lattig MC, Lima YC, Lin YS, López-León S, Loureiro CM, Martínez-Cerdeño V, Martínez-Levy GA, Melin K, Moreno-De-Luca D, Muniz Carvalho C, Olivares AM, Oliveira VF, Ormond R, Palmer AA, Panzenhagen AC, Passos-Bueno MR, Peng Q, Pérez-Palma E, Prieto ML, Roussos P, Sanchez-Roige S, Santamaría-García H, Shansis FM, Sharp RR, Storch EA, Tavares MEA, Tietz GE, Torres-Hernández BA, Tovo-Rodrigues L, Trelles P, Trujillo-ChiVacuan EM, Velásquez MM, Vera-Urbina F, Voloudakis G, Wegman-Ostrosky T, Zhen-Duan J, Zhou H, Latin American Genomics Consortium, Santoro ML, Nicolini H, Atkinson EG, Giusti-Rodríguez P, Montalvo-Ortiz JL. PMID: 40175716; PMCID: PMC12133068.
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Humans
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Genetic Propensity for Delay Discounting and Educational Attainment in Adults Are Associated With Delay Discounting in Preadolescents: Findings From the Adolescent Brain Cognitive Development Study. Genes Brain Behav. 2025 Apr; 24(2):e70020.
Rabinowitz JA, Thomas N, Strickland JC, Meredith JJ, Hung IT, Cupertino RB, Felton JW, Gelino B, Stone B, Maher BS, Dick D, Yi R, Flores-Ocampo V, García-Marín LM, Rentería ME, Palmer AA, Sanchez-Roige S. PMID: 40147852; PMCID: PMC11949538.
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1 Fields:
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Humans
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RatXcan: A framework for cross-species integration of genome-wide association and gene expression data. PLoS Genet. 2025 Mar; 21(3):e1011583.
Santhanam N, Sanchez-Roige S, Mi S, Liang Y, Chitre AS, Munro D, Chen D, Gao J, Garcia-Martinez A, George AM, Gileta AF, Han W, Holl K, Hughson A, King CP, Lamparelli AC, Martin CD, Nyasimi F, St Pierre CL, Sumner S, Tripi J, Wang T, Chen H, Flagel S, Ishiwari K, Meyer P, Polesskaya O, Saba L, Solberg Woods LC, Palmer AA, Im HK. PMID: 40163524; PMCID: PMC12052193.
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HumansAnimalsCells
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Subjective Response to Opioids Predicts Risk for Opioid Use Disorder. medRxiv. 2025 Mar 23.
Gonzalez J, Tran V, Meredith J, Xu I, Penchala R, Vilar Ribo L, Courchesne-Krak NS, Zoleikhaeian D, 23andMe Research Team, McIntyre M, Fontanillas P, Kukar Bond K, Johnson EO, Jeffery A, MacKillop J, Marienfeld C, de Wit H, Palmer AA, Sanchez-Roige S. PMID: 40166554; PMCID: PMC11957173.
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Gene discovery and pleiotropic architecture of Chronic Pain in a Genome-wide Association Study of >1.2 million Individuals. medRxiv. 2025 Mar 05.
Toikumo S, Davis C, Jinwala Z, Khan Y, Jennings M, Davis L, Sanchez-Roige S, Kember RL, Kranzler HR. PMID: 40093235; PMCID: PMC11908286.
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Delay discounting data in the Adolescent Brain Cognitive Development (ABCD) study: Modeling and analysis considerations. Exp Clin Psychopharmacol. 2025 Jun; 33(3):225-238.
Gelino BW, Rabinowitz JA, Maher BS, Felton JW, Yi R, Novak MD, Sanchez-Roige S, Palmer AA, Strickland JC. PMID: 39992757; PMCID: PMC12097935.
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Impulsivity facets and substance use involvement: insights from genomic structural equation modeling. Psychol Med. 2025 Feb 17; 55:e51.
Vilar-Ribó L, Hatoum AS, Grotzinger AD, Mallard TT, 23andMe Research Team, Elson S, Fontanillas P, Palmer AA, Gustavson DE, Sanchez-Roige S. PMID: 39957498; PMCID: PMC12039315.
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3 Fields:
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Humans
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Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. medRxiv. 2025 Feb 03.
Johnson EC, Lai D, Miller AP, Hatoum AS, Deak JD, Balbona JV, Baranger DA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SM, Sanchez-Roige S, Adhikari K, Docherty A, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries P, Korhonen T, Morrison C, Nunez YZ, Palviainen T, Su MH, Villela PNR, Wetherill L, Willoughby EA, Zellers S, Bierut L, Buchwald J, Copeland W, Corley R, Friedman NP, Foroud TM, Gillespie NA, Gizer IR, Heath AC, Hickie IB, Kaprio JA, Keller MC, Lee JL, Lind PA, Madden PA, Maes HH, Martin NG, McGue M, Medland SE, Nelson EC, Pearson JV, Porjesz B, Stallings M, Vrieze S, Wilhelmsen KC, Walters RK, Polimanti R, Malison RT, Zhou H, Stefansson K, Potenza MN, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg HJ, Gelernter J, Agrawal A. PMID: 39974067; PMCID: PMC11838619.
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The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders. medRxiv. 2025 Jan 15.
Grotzinger AD, Werme J, Peyrot WJ, Frei O, de Leeuw C, Bicks LK, Guo Q, Margolis MP, Coombes BJ, Batzler A, Pazdernik V, Biernacka JM, Andreassen OA, Anttila V, Børglum AD, Cai N, Demontis D, Edenberg HJ, Faraone SV, Franke B, Gandal MJ, Gelernter J, Hettema JM, Jonas KG, Knowles JA, Koenen KC, Maihofer AX, Mallard TT, Mattheisen M, Mitchell KS, Neale BM, Nievergelt CM, Nurnberger JI, O'Connell KS, Robinson EB, Sanchez-Roige SS, Santangelo SL, Stefansson H, Stefansson K, Stein MB, Strom NI, Thornton LM, Tucker-Drob EM, Verhulst B, Waldman ID, Walters GB, Wray NR, Anxiety Disorders Working Group, Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group, Autism Spectrum Disorders Working Group, Bipolar Disorder Working Group, Eating Disorders Working Group, Major Depressive Disorder Working Group, Nicotine Dependence GenOmics (iNDiGO) Consortium, Obsessive-Compulsive Disorder Working Group, Post-Traumatic Stress Disorder Working Group, Schizophrenia Working Group, Substance Use Disorders Working Group, Tourette Syndrome Working Group, Lee PH, Kendler KS, Smoller JW. PMID: 40568675; PMCID: PMC12191084.
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Identification of Transdiagnostic Childhood Externalizing Pathology Within an Electronic Medical Records Database and Application to the Analysis of Rare Copy Number Variation. Am J Med Genet B Neuropsychiatr Genet. 2025 Jun; 198(4):e33020.
Reddy IA, Han L, Sanchez-Roige S, Niarchou M, Ruderfer DM, Davis LK. PMID: 39744833; PMCID: PMC12048253.
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Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nat Neurosci. 2025 Jan; 28(1):213.
Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. PMID: 39643700.
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1 Fields:
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Genomic structural equation modeling of reward-related traits: exploring the genetic factor structure and its relationship with psychopathology. Psychiatry Res. 2025 Feb; 344:116335.
Cardoso Melo D, Trindade Pons V, Mallard TT, Sanchez-Roige S, Palmer AA, Xie T, Snieder H, Hartman CA. PMID: 39721098.
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1 Fields:
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Humans
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Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction. Biol Psychiatry. 2025 Jul 01; 98(1):11-22.
Sullivan KA, Kainer D, Lane M, Cashman M, Miller JI, Garvin MR, Townsend A, Quach BC, Willis C, Kruse P, Gaddis NC, Mathur R, Corradin O, Maher BS, Scacheri PC, Sanchez-Roige S, Palmer AA, Troiani V, Chesler EJ, Kember RL, Kranzler HR, Justice AC, Xu K, Aouizerat BE, Hancock DB, Johnson EO, Jacobson DA, VA Million Veteran Program. PMID: 39615775; PMCID: PMC12119972.
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PubMed Mentions: Fields:
Translation:
HumansCells
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An emerging multi-omic understanding of the genetics of opioid addiction. J Clin Invest. 2024 Oct 15; 134(20).
Johnson EO, Fisher HS, Sullivan KA, Corradin O, Sanchez-Roige S, Gaddis NC, Sami YN, Townsend A, Teixeira Prates E, Pavicic M, Kruse P, Chesler EJ, Palmer AA, Troiani V, Bubier JA, Jacobson DA, Maher BS. PMID: 39403933; PMCID: PMC11473141.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors. Am J Psychiatry. 2024 Nov 01; 181(11):1006-1017.
Savage JE, Barr PB, Phung T, Lee YH, Zhang Y, McCutcheon VV, COGA Investigators, Ge T, Smoller JW, Davis LK, Meyers J, Porjesz B, Posthuma D, Mallard TT, Sanchez-Roige S. PMID: 39380376.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Do polygenic indices capture "direct" effects on child externalizing behavior problems? Within-family analyses in two longitudinal birth cohorts. Clin Psychol Sci. 2025 Mar; 13(2):316-331.
Tanksley PT, Brislin SJ, Wertz J, de Vlaming R, Courchesne-Krak NS, Mallard TT, Raffington LL, Karlsson Linnér R, Koellinger P, Palmer AA, Sanchez-Roige S, Waldman ID, Dick D, Moffitt TE, Caspi A, Harden KP. PMID: 40110515; PMCID: PMC11922333.
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PubMed Mentions:
5
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A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens. Sci Rep. 2024 Aug 06; 14(1):18258.
Reiner BC, Chehimi SN, Merkel R, Toikumo S, Berrettini WH, Kranzler HR, Sanchez-Roige S, Kember RL, Schmidt HD, Crist RC. PMID: 39107568; PMCID: PMC11303397.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits. medRxiv. 2024 Jul 29.
Davis CN, Toikumo S, Hatoum AS, Khan Y, Pham BK, Pakala SR, Feuer KL, Gelernter J, Sanchez-Roige S, Kember RL, Kranzler HR. PMID: 39132487; PMCID: PMC11312645.
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PubMed Mentions:
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Rare and common variants associated with alcohol consumption identify a conserved molecular network. Alcohol Clin Exp Res (Hoboken). 2024 Sep; 48(9):1704-1715.
Leger BS, Meredith JJ, Ideker T, Sanchez-Roige S, Palmer AA. PMID: 39031522; PMCID: PMC11576244.
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PubMed Mentions:
3 Fields:
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Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. Neuropsychopharmacology. 2024 Oct; 49(11):1655-1665.
Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A. PMID: 38906991; PMCID: PMC11399264.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
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Genome-wide association studies of lifetime and frequency cannabis use in 131,895 individuals. medRxiv. 2024 Jun 15.
Thorpe HHA, Fontanillas P, Meredith JJ, Jennings MV, Cupertino RB, Pakala S, 23andMe Research Team, Elson SL, Khokhar JY, Davis LK, Johnson EC, Palmer AA, Sanchez-Roige S. PMID: 38947071; PMCID: PMC11213095.
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PubMed Mentions:
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Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations. Neuropsychopharmacology. 2024 Sep; 49(10):1609-1618.
Thorpe HHA, Fontanillas P, Pham BK, Meredith JJ, Jennings MV, Courchesne-Krak NS, Vilar-Ribó L, Bianchi SB, Mutz J, 23andMe Research Team, Elson SL, Khokhar JY, Abdellaoui A, Davis LK, Palmer AA, Sanchez-Roige S. PMID: 38858598; PMCID: PMC11319477.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens. bioRxiv. 2024 May 26.
Reiner BC, Chehimi SN, Merkel R, Toikumo S, Berrettini WH, Kranzler HR, Sanchez-Roige S, Kember RL, Schmidt HD, Crist RC. PMID: 38826289; PMCID: PMC11142250.
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PubMed Mentions:
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Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample. medRxiv. 2024 May 10.
Khan Y, Davis CN, Jinwala Z, Feuer KL, Toikumo S, Hartwell EE, Sanchez-Roige S, Peterson RE, Hatoum AS, Kranzler HR, Kember RL, Khan Y, Davis CN, Jinwala Z, Feuer KL, Toikumo S, Hartwell EE, Sanchez-Roige S, Peterson RE, Hatoum AS, Kranzler HR, Kember RL. PMID: 38766259; PMCID: PMC11100926.
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PubMed Mentions:
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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. Nat Hum Behav. 2024 Jun; 8(6):1177-1193.
Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik VK, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M, Penn Medicine BioBank, Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. PMID: 38632388; PMCID: PMC11199106.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. EBioMedicine. 2024 05; 103:105086.
Jennings MV, Martínez-Magaña JJ, Courchesne-Krak NS, Cupertino RB, Vilar-Ribó L, Bianchi SB, Hatoum AS, Atkinson EG, Giusti-Rodriguez P, Montalvo-Ortiz JL, Gelernter J, Artigas MS, 23andMe, Inc. Research Team, Elson SL, Edenberg HJ, Fontanillas P, Palmer AA, Sanchez-Roige S. PMID: 38580523; PMCID: PMC11121167.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Rare and Common Variants Associated with Alcohol Consumption Identify a Conserved Molecular Network. bioRxiv. 2024 Mar 01.
Leger BS, Meredith JJ, Ideker T, Sanchez-Roige S, Palmer AA. PMID: 38464225; PMCID: PMC10925118.
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PubMed Mentions:
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Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. JAMA Psychiatry. 2024 Feb 01; 81(2):188-197.
Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Harden KP, Wilkinson A, Graham DP, Nielsen DA, Swann AC, Lipsky RK, Kosten TR, Aslan M, Harvey PD, Kimbrel NA, Beckham JC, Million Veteran Program (MVP)Cooperative Studies Program (CSP) #572. PMID: 37938835; PMCID: PMC10633411.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. medRxiv. 2024 Jan 18.
Johnson EC, Austin-Zimmerman I, Thorpe HH, Levey DF, Baranger DA, Colbert SM, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Forti MD, Sanchez-Roige S, Gelernter J, Agrawal A. PMID: 38293235; PMCID: PMC10827265.
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PubMed Mentions:
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Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records. Transl Psychiatry. 2024 Jan 10; 14(1):20.
Niarchou M, Sanchez-Roige S, Reddy IA, Reese TJ, Marcovitz D, Davis LK. PMID: 38200003; PMCID: PMC10781771.
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PubMed Mentions: Fields:
Translation:
Humans
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Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Nat Med. 2023 Dec; 29(12):3184-3192.
Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Nielsen TT, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A, Million Veteran Program, Justice AC, Stein MB, Kranzler HR, Gelernter J. PMID: 38062264; PMCID: PMC10719093.
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PubMed Mentions:
68 Fields:
Translation:
Humans
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Executive Function and Impulsivity Predict Distinct Genetic Variance in Internalizing Problems, Externalizing Problems, Thought Disorders, and Compulsive Disorders: A Genomic Structural Equation Modeling Study. Clin Psychol Sci. 2024 Sep; 12(5):865-881.
Gustavson DE, Morrison CL, Mallard TT, Jennings MV, Fontanillas P, Elson SL, Palmer AA, Friedman NP, Sanchez-Roige S. PMID: 39323941; PMCID: PMC11423426.
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PubMed Mentions:
5
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Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes. medRxiv. 2023 Sep 18.
Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik V, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M, Penn Medicine BioBank, Million Veteran Program, PsycheMERGE Substance Use Disorder Workgroup, Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. PMID: 37034728; PMCID: PMC10081388.
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PubMed Mentions:
1
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Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. Behav Genet. 2023 11; 53(5-6):404-415.
Williams CM, Poore H, Tanksley PT, Kweon H, Courchesne-Krak NS, Londono-Correa D, Mallard TT, Barr P, Koellinger PD, Waldman ID, Sanchez-Roige S, Harden KP, Palmer AA, Dick DM, Karlsson Linnér R. PMID: 37713023; PMCID: PMC10584908.
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PubMed Mentions:
8 Fields:
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Genome-Wide Association Studies of Coffee Intake in UK/US Participants of European Ancestry Uncover Gene-Cohort Influences. medRxiv. 2023 Sep 11.
Thorpe HHA, Fontanillas P, Pham BK, Meredith JJ, Jennings MV, Courchesne-Krak NS, Vilar-Ribó L, Bianchi SB, Mutz J, 23andMe Research Team, Elson SL, Khokhar JY, Abdellaoui A, Davis LK, Palmer AA, Sanchez-Roige S. PMID: 37745582; PMCID: PMC10516045.
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PubMed Mentions:
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A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders. Addict Biol. 2023 09; 28(9):e13319.
Poore HE, Hatoum A, Mallard TT, Sanchez-Roige S, Waldman ID, Palmer AA, Harden KP, Barr PB, Dick DM. PMID: 37644899; PMCID: PMC11010459.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. medRxiv. 2023 Jul 11.
Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Paige Harden K, Wilkinson A, Graham DP, Nielsen DA, Swann A, Lipsky RK, Kosten T, Aslan M, Harvey PD, Kimbrel NA, Beckham JC. PMID: 37034805; PMCID: PMC10081391.
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PubMed Mentions:
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Detecting Problematic Opioid Use in the Electronic Health Record: Automation of the Addiction Behaviors Checklist in a Chronic Pain Population. medRxiv. 2023 Jun 12.
Chatham AH, Bradley ED, Schirle L, Sanchez-Roige S, Samuels DC, Jeffery AD. PMID: 37398208; PMCID: PMC10312835.
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PubMed Mentions:
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Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample. Am J Psychiatry. 2023 08 01; 180(8):584-593.
Kember RL, Vickers-Smith R, Zhou H, Xu H, Jennings M, Dao C, Davis L, Sanchez-Roige S, Justice AC, Gelernter J, Vujkovic M, Kranzler HR. PMID: 37282553; PMCID: PMC10731616.
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PubMed Mentions:
21 Fields:
Translation:
Humans
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Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts. medRxiv. 2023 Jun 04.
Tanksley PT, Brislin SJ, Wertz J, de Vlaming R, Courchesne-Krak NS, Mallard TT, Raffington LL, Linnér RK, Koellinger P, Palmer A, Sanchez-Roige A, Waldman I, Dick D, Moffitt TE, Caspi A, Harden KP. PMID: 37398155; PMCID: PMC10312898.
View in:
PubMed Mentions:
1
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CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Transl Psychiatry. 2023 05 12; 13(1):167.
Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf LC, Bianchi SB, Huang Y, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage CE, Schafer D, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW, Palmer AA. PMID: 37173343; PMCID: PMC10182097.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimals
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Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. bioRxiv. 2023 Mar 24.
Williams CM, Poore H, Tanksley PT, Kweon H, Courchesne-Krak NS, Londono-Correa D, Mallard TT, Barr P, Koellinger PD, Waldman ID, Sanchez-Roige S, Harden KP, Palmer AA, Dick DM, Linnér RK. PMID: 36993611; PMCID: PMC10055200.
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PubMed Mentions:
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Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. Nat Ment Health. 2023 Mar; 1(3):210-223.
Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. PMID: 37250466; PMCID: PMC10217792.
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PubMed Mentions:
107
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Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan. Neuropsychopharmacology. 2023 06; 48(7):981-990.
Vilar-Ribó L, Cabana-Domínguez J, Martorell L, Ramos-Quiroga JA, Sanchez-Roige S, Palmer AA, Vilella E, Ribasés M, Muntané G, Soler Artigas M. PMID: 36906694; PMCID: PMC10209393.
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PubMed Mentions: Fields:
Translation:
Humans
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Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals. medRxiv. 2023 Jan 30.
Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A, Million Veteran Program, Justice AC, Stein MB, Kranzler HR, Gelernter J. PMID: 36747741; PMCID: PMC9901058.
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PubMed Mentions:
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Identifying problematic opioid use in electronic health record data: Are we looking in the right place? J Opioid Manag. 2023; 19(1):5-9.
Schirle L, Kwun S, Suh A, Sanchez-Roige S, Jeffery AD, Samuels DC. PMID: 36683296; PMCID: PMC9987029.
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PubMed Mentions: Fields:
Translation:
Humans
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Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting. Transl Psychiatry. 2022 Nov 19; 12(1):486.
Mack T, Sanchez-Roige S, Davis LK. PMID: 36402754; PMCID: PMC9675730.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk. Transl Psychiatry. 2022 09 30; 12(1):420.
Barr PB, Mallard TT, Sanchez-Roige S, Poore HE, Linnér RK, COGA Collaborators, Waldman ID, Palmer AA, Harden KP, Dick DM. PMID: 36180423; PMCID: PMC9525649.
View in:
PubMed Mentions:
9 Fields:
Translation:
Humans
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Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. Nat Neurosci. 2022 Oct; 25(10):1279-1287.
Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC, Rentsch CT, Million Veteran Program, Davis LK, Justice AC, Sanchez-Roige S, Kampman KM, Gelernter J, Kranzler HR. PMID: 36171425; PMCID: PMC9682545.
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PubMed Mentions:
55 Fields:
Translation:
Humans
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Substance use and common contributors to morbidity: A genetics perspective. EBioMedicine. 2022 Sep; 83:104212.
Sanchez-Roige S, Kember RL, Agrawal A. PMID: 35970022; PMCID: PMC9399262.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci. Mol Psychiatry. 2022 10; 27(10):3970-3979.
Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. PMID: 35879402; PMCID: PMC9718667.
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PubMed Mentions:
56 Fields:
Translation:
Humans
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A phenome-wide association study of polygenic scores for attention deficit hyperactivity disorder across two genetic ancestries in electronic health record data. Am J Med Genet B Neuropsychiatr Genet. 2022 Sep; 189(6):185-195.
Niarchou M, Sealock JM, Straub P, Sanchez-Roige S, Sutcliffe JS, Davis LK. PMID: 35841203; PMCID: PMC9378640.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Cross-ancestry genomic research: time to close the gap. Neuropsychopharmacology. 2022 09; 47(10):1737-1738.
Atkinson EG, Bianchi SB, Ye GY, Martínez-Magaña JJ, Tietz GE, Montalvo-Ortiz JL, Giusti-Rodriguez P, Palmer AA, Sanchez-Roige S. PMID: 35739257; PMCID: PMC9372026.
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PubMed Mentions:
11 Fields:
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Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities. Cell Genom. 2022 06 08; 2(6).
Mallard TT, Linnér RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okbay A, de Vlaming R, Meddens SFW, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Palmer AA, Davis LK, Tucker-Drob EM, Kendler KS, Keller MC, Koellinger PD, Harden KP. PMID: 35812988; PMCID: PMC9264403.
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PubMed Mentions:
50 Fields:
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Identifying High-Risk Comorbidities Associated with Opioid Use Patterns Using Electronic Health Record Prescription Data. Complex Psychiatry. 2022 Sep; 8(1-2):47-55.
Jennings MV, Lee H, Rocha DB, Bianchi SB, Coombes BJ, Crist RC, Faucon AB, Hu Y, Kember RL, Mallard TT, Niarchou M, Poulsen MN, Straub P, Urman RD, Walsh CG, Davis LK, Smoller JW, Troiani V, Sanchez-Roige S. PMID: 36545045; PMCID: PMC9669950.
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PubMed Mentions:
10
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Accelerating Opioid Use Disorders Research by Integrating Multiple Data Modalities. Complex Psychiatry. 2022 Sep; 8(1-2):1-8.
Bianchi SB, Jeffery AD, Samuels DC, Schirle L, Palmer AA, Sanchez-Roige S. PMID: 36545043; PMCID: PMC9669996.
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PubMed Mentions:
1
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A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting. Genes Brain Behav. 2022 04; 21(4):e12800.
Sanchez-Roige S, Barnes SA, Mallari J, Wood R, Polesskaya O, Palmer AA. PMID: 35243767; PMCID: PMC9211103.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Evaluation of delay discounting as a transdiagnostic research domain criteria indicator in 1388 general community adults. Psychol Med. 2023 03; 53(4):1649-1657.
Levitt EE, Oshri A, Amlung M, Ray LA, Sanchez-Roige S, Palmer AA, MacKillop J. PMID: 35080193; PMCID: PMC10009385.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry. Mol Psychiatry. 2021 11; 26(11):6209-6217.
Sanchez-Roige S, Fontanillas P, Jennings MV, Bianchi SB, Huang Y, Hatoum AS, Sealock J, Davis LK, Elson SL, 23andMe Research Team, Palmer AA. PMID: 34728798; PMCID: PMC8562028.
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PubMed Mentions:
29 Fields:
Translation:
Humans
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Two data-driven approaches to identifying the spectrum of problematic opioid use: A pilot study within a chronic pain cohort. Int J Med Inform. 2021 12; 156:104621.
Schirle L, Jeffery A, Yaqoob A, Sanchez-Roige S, Samuels DC. PMID: 34673309; PMCID: PMC8609775.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nat Neurosci. 2021 10; 24(10):1367-1376.
Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. PMID: 34446935; PMCID: PMC8484054.
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PubMed Mentions:
167 Fields:
Translation:
Humans
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Dimensional Phenotypes in Psychiatric Genetics: Lessons from Genome-Wide Association Studies of Alcohol Use Phenotypes. Complex Psychiatry. 2021 Dec; 7(3-4):45-48.
Mallard TT, Sanchez-Roige S. PMID: 35083441; PMCID: PMC8739983.
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PubMed Mentions:
9
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Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. Behav Genet. 2021 09; 51(5):543-558.
Kuo SI, Salvatore JE, Barr PB, Aliev F, Anokhin A, Bucholz KK, Chan G, Edenberg HJ, Hesselbrock V, Kamarajan C, Kramer JR, Lai D, Mallard TT, Nurnberger JI, Pandey G, Plawecki MH, Sanchez-Roige S, Waldman I, Palmer AA, Externalizing Consortium, Dick DM. PMID: 34117972; PMCID: PMC8403154.
View in:
PubMed Mentions:
15 Fields:
Translation:
Humans
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Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. Am J Psychiatry. 2022 Jan; 179(1):58-70.
Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA, Sanchez-Roige S. PMID: 33985350; PMCID: PMC9272895.
View in:
PubMed Mentions:
59 Fields:
Translation:
Humans
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Integration of evidence across human and model organism studies: A meeting report. Genes Brain Behav. 2021 Apr 23; e12738.
Palmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca-Bachman CE, Parker CC, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, Lai D, Quach BC, Gaddis NC, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez-Roige S, Bandrowski A, Lu Q, Shen L, Philip V, Gelernter J, Bierut LJ, Hancock DB, Edenberg HJ, Johnson EO, Nestler EJ, Barr PB, Prins P, Smith DJ, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobson D, Palmer AA, Miles M, Chesler EJ, Emerson J, Agrawal A, Martone M, Williams RW. PMID: 33893716; PMCID: PMC8365690.
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PubMed Mentions:
12 Fields:
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Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence. Drug Alcohol Depend. 2021 04 01; 221:108612.
Sanchez-Roige S, Cox NJ, Johnson EO, Hancock DB, Davis LK. PMID: 33631543; PMCID: PMC8026738.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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A large-scale genome-wide association study meta-analysis of cannabis use disorder. Lancet Psychiatry. 2020 12; 7(12):1032-1045.
Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, Reginsson GW, Zhou H, He J, Baranger DAA, Gudbjartsson DF, Wedow R, Adkins DE, Adkins AE, Alexander J, Bacanu SA, Bigdeli TB, Boden J, Brown SA, Bucholz KK, Bybjerg-Grauholm J, Corley RP, Degenhardt L, Dick DM, Domingue BW, Fox L, Goate AM, Gordon SD, Hack LM, Hancock DB, Hartz SM, Hickie IB, Hougaard DM, Krauter K, Lind PA, McClintick JN, McQueen MB, Meyers JL, Montgomery GW, Mors O, Mortensen PB, Nordentoft M, Pearson JF, Peterson RE, Reynolds MD, Rice JP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Tarter RE, Tyrfingsson T, Wall TL, Webb BT, Werge T, Wetherill L, Wright MJ, Zellers S, Adams MJ, Bierut LJ, Boardman JD, Copeland WE, Farrer LA, Foroud TM, Gillespie NA, Grucza RA, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono WG, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Madden PAF, Maes HH, Maher BS, Martin NG, McGue M, McIntosh AM, Medland SE, Nelson EC, Porjesz B, Riley BP, Stallings MC, Vanyukov MM, Vrieze S, Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Davis LK, Bogdan R, Gelernter J, Edenberg HJ, Stefansson K, Børglum AD, Agrawal A. PMID: 33096046; PMCID: PMC7674631.
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PubMed Mentions:
182 Fields:
Translation:
Humans
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The Latent Genetic Structure of Impulsivity and Its Relation to Internalizing Psychopathology. Psychol Sci. 2020 08; 31(8):1025-1035.
Gustavson DE, Friedman NP, Fontanillas P, Elson SL, 23andMe Research Team, Palmer AA, Sanchez-Roige S. PMID: 32716714; PMCID: PMC7427138.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nat Neurosci. 2020 07; 23(7):809-818.
Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. PMID: 32451486; PMCID: PMC7485556.
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PubMed Mentions:
218 Fields:
Translation:
Humans
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Emerging phenotyping strategies will advance our understanding of psychiatric genetics. Nat Neurosci. 2020 04; 23(4):475-480.
Sanchez-Roige S, Palmer AA. PMID: 32231337; PMCID: PMC9200410.
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PubMed Mentions:
35 Fields:
Translation:
Humans
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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addict Biol. 2021 01; 26(1):e12880.
Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, Yilmaz Z, Baker JH, Hübel C, Gordon S, Medland SE, Watson HJ, Gaspar HA, Bryois J, Hinney A, Leppä VM, Mattheisen M, Ripke S, Yao S, Giusti-Rodríguez P, Hanscombe KB, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Berrettini WH, Boehm I, Boni C, Boraska Perica V, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter MM, Fischer K, Föcker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Gratacos Mayora M, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op't Landt MCT, Slopien A, Sorbi S, Swiatkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell J, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Grove J, Henders AK, Larsen JT, Parker R, Petersen LV, Jordan J, Kennedy MA, Birgegård A, Lichtenstein P, Norring C, Landén M, Mortensen PB, Polimanti R, McClintick JN, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Degenhardt F, Docherty AR, Edwards AC, Foo JC, Fox L, Frank J, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Hodgkinson C, Hoffmann P, Hottenga JJ, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Peterson RE, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Zhou H, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Frye MA, Gäebel W, Hayward C, Ising M, Keyes M, Kiefer F, Koller G, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt SH, Wodarz N, Zill P, Adkins DE, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Costello EJ, de Wit H, Diazgranados N, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Hesselbrock V, Hewitt JK, et al. PMID: 32064741; PMCID: PMC7429266.
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PubMed Mentions:
28 Fields:
Translation:
Humans
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Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples. Psychol Med. 2021 05; 51(7):1147-1156.
Johnson EC, Sanchez-Roige S, Acion L, Adams MJ, Bucholz KK, Chan G, Chao MJ, Chorlian DB, Dick DM, Edenberg HJ, Foroud T, Hayward C, Heron J, Hesselbrock V, Hickman M, Kendler KS, Kinreich S, Kramer J, Kuo SI, Kuperman S, Lai D, McIntosh AM, Meyers JL, Plawecki MH, Porjesz B, Porteous D, Schuckit MA, Su J, Zang Y, Palmer AA, Agrawal A, Clarke TK, Edwards AC. PMID: 31955720; PMCID: PMC7405725.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Steep Discounting of Future Rewards as an Impulsivity Phenotype: A Concise Review. Curr Top Behav Neurosci. 2020; 47:113-138.
Levitt E, Sanchez-Roige S, Palmer AA, MacKillop J. PMID: 32236897.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease. Mol Psychiatry. 2021 08; 26(8):4254-4264.
Dennis J, Sealock J, Levinson RT, Farber-Eger E, Franco J, Fong S, Straub P, Hucks D, Song WL, Linton MF, Fontanillas P, Elson SL, Ruderfer D, Abdellaoui A, Sanchez-Roige S, Palmer AA, Boomsma DI, Cox NJ, Chen G, Mosley JD, Wells QS, Davis LK. PMID: 31796895; PMCID: PMC7266730.
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PubMed Mentions:
27 Fields:
Translation:
Humans
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Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness. Hum Mol Genet. 2019 11 15; 28(22):3853-3865.
Abdellaoui A, Sanchez-Roige S, Sealock J, Treur JL, Dennis J, Fontanillas P, Elson S, 23andme Research Team, Nivard MG, Ip HF, van der Zee M, Baselmans BML, Hottenga JJ, Willemsen G, Mosing M, Lu Y, Pedersen NL, Denys D, Amin N, M van Duijn C, Szilagyi I, Tiemeier H, Neumann A, Verweij KJH, Cacioppo S, Cacioppo JT, Davis LK, Palmer AA, Boomsma DI. PMID: 31518406; PMCID: PMC6935385.
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PubMed Mentions:
49 Fields:
Translation:
Humans
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Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse. Biol Psychiatry. 2020 04 01; 87(7):609-618.
Sanchez-Roige S, Palmer AA, Clarke TK. PMID: 31733789; PMCID: PMC7071963.
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PubMed Mentions:
51 Fields:
Translation:
Humans
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Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability. Nat Neurosci. 2019 Jul; 22(7):1196.
Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, 23andMe Research Team, de Wit H, Davis LK, MacKillop J, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. PMID: 31168101.
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PubMed Mentions:
5 Fields:
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Genomic basis of delayed reward discounting. Behav Processes. 2019 May; 162:157-161.
Gray JC, Sanchez-Roige S, de Wit H, MacKillop J, Palmer AA. PMID: 30876880; PMCID: PMC6980721.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2019 Mar; 22(3):503.
Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 30622366.
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PubMed Mentions: Fields:
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Electronic Health Records Are the Next Frontier for the Genetics of Substance Use Disorders. Trends Genet. 2019 05; 35(5):317-318.
Sanchez-Roige S, Palmer AA. PMID: 30797598; PMCID: PMC6984003.
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PubMed Mentions:
6 Fields:
Translation:
HumansPHPublic Health
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Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the CACNA1I and CADM2 genes. J Neurosci. 2019 03 27; 39(13):2562-2572.
Sanchez-Roige S, Fontanillas P, Elson SL, Gray JC, de Wit H, MacKillop J, Palmer AA. PMID: 30718321; PMCID: PMC6435820.
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PubMed Mentions:
77 Fields:
Translation:
Humans
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nat Genet. 2019 02; 51(2):245-257.
Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A, Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F, 23and Me Research Team, eQTLgen Consortium, International Cannabis Consortium, Social Science Genetic Association Consortium, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP. PMID: 30643258; PMCID: PMC6713272.
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PubMed Mentions:
348 Fields:
Translation:
Humans
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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018 12; 21(12):1656-1669.
Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, 23andMe Research Team, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A. PMID: 30482948; PMCID: PMC6430207.
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PubMed Mentions:
362 Fields:
Translation:
Humans
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Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. Am J Psychiatry. 2019 02 01; 176(2):107-118.
Sanchez-Roige S, Palmer AA, Fontanillas P, Elson SL, 23andMe Research Team, the Substance Use Disorder Working Group of the Psychiatric Genomics Consorti, Adams MJ, Howard DM, Edenberg HJ, Davies G, Crist RC, Deary IJ, McIntosh AM, Clarke TK. PMID: 30336701; PMCID: PMC6365681.
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PubMed Mentions:
229 Fields:
Translation:
Humans
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Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. Exp Clin Psychopharmacol. 2019 Feb; 27(1):29-37.
MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA, de Wit H. PMID: 30265060; PMCID: PMC6908809.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci. 2018 09; 21(9):1161-1170.
Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, 23andMe Research Team, de Wit H, Davis LK, MacKillop J, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. PMID: 30150663; PMCID: PMC6386176.
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PubMed Mentions:
239 Fields:
Translation:
Humans
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The genetics of human personality. Genes Brain Behav. 2018 03; 17(3):e12439.
Sanchez-Roige S, Gray JC, MacKillop J, Chen CH, Palmer AA. PMID: 29152902; PMCID: PMC7012279.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 01; 21(1):16-18.
Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 29230059; PMCID: PMC6984001.
View in:
PubMed Mentions:
64 Fields:
Translation:
Humans
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Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. Addict Biol. 2019 01; 24(1):121-131.
Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 29058377; PMCID: PMC6988186.
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PubMed Mentions:
62 Fields:
Translation:
HumansPHPublic Health
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Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation. Neuropsychopharmacology. 2017 Mar; 42(4):811-821.
Gao J, Davis LK, Hart AB, Sanchez-Roige S, Han L, Cacioppo JT, Palmer AA. PMID: 27629369; PMCID: PMC5312064.
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PubMed Mentions:
38 Fields:
Translation:
Humans
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Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol Intake. Alcohol Clin Exp Res. 2016 10; 40(10):2208-2217.
Sanchez-Roige S, Stephens DN, Duka T. PMID: 27565012.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse. Front Genet. 2016; 7:52.
Peña-Oliver Y, Carvalho FM, Sanchez-Roige S, Quinlan EB, Jia T, Walker-Tilley T, Rulten SL, Pearl FM, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Conrod PJ, Flor H, Gallinat J, Garavan H, Heinz A, Gowland P, Paillere Martinot ML, Paus T, Rietschel M, Robbins TW, Smolka MN, Schumann G, Stephens DN, IMAGEN Consortium. PMID: 27092175; PMCID: PMC4823271.
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PubMed Mentions:
12
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Long-term moderate treadmill exercise promotes stress-coping strategies in male and female rats. Sci Rep. 2015 Nov 05; 5:16166.
Lalanza JF, Sanchez-Roige S, Cigarroa I, Gagliano H, Fuentes S, Armario A, Capdevila L, Escorihuela RM. PMID: 26538081; PMCID: PMC4633642.
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PubMed Mentions:
23 Fields:
Translation:
Animals
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The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice. Psychopharmacology (Berl). 2015 Sep; 232(18):3431-41.
Ripley TL, Sanchez-Roige S, Bullmore ET, Mugnaini M, Maltby K, Miller SR, Wille DR, Nathan P, Stephens DN. PMID: 26141191; PMCID: PMC4537503.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Alleviating waiting impulsivity and perseverative responding by μ-opioid receptor antagonism in two inbred mouse strains. Psychopharmacology (Berl). 2015 Apr; 232(8):1483-92.
Sanchez-Roige S, Ripley TL, Stephens DN. PMID: 25381183.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Repeated ethanol exposure during early and late adolescence: double dissociation of effects on waiting and choice impulsivity. Alcohol Clin Exp Res. 2014 Oct; 38(10):2579-89.
Sanchez-Roige S, Peña-Oliver Y, Ripley TL, Stephens DN. PMID: 25346503.
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PubMed Mentions:
23 Fields:
Translation:
Animals
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Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence. Age (Dordr). 2014; 36(5):9697.
Sanchez-Roige S, Lalanza JF, Alvarez-López MJ, Cosín-Tomás M, Griñan-Ferré C, Pallàs M, Kaliman P, Escorihuela RM. PMID: 25129573; PMCID: PMC4159468.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Voluntary exercise promotes beneficial anti-aging mechanisms in SAMP8 female brain. J Mol Neurosci. 2015 Feb; 55(2):525-32.
Bayod S, Guzmán-Brambila C, Sanchez-Roige S, Lalanza JF, Kaliman P, Ortuño-Sahagun D, Escorihuela RM, Pallàs M. PMID: 25027560.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Exaggerated waiting impulsivity associated with human binge drinking, and high alcohol consumption in mice. Neuropsychopharmacology. 2014 Dec; 39(13):2919-27.
Sanchez-Roige S, Baro V, Trick L, Peña-Oliver Y, Stephens DN, Duka T. PMID: 24947901; PMCID: PMC4229569.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimals
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Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues. J Physiol Pharmacol. 2014 Apr; 65(2):229-39.
Bayod S, Del Valle J, Pelegri C, Vilaplana J, Canudas AM, Camins A, Jimenez A, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Pallas M. PMID: 24781732.
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14 Fields:
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Animals
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Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise. Front Aging Neurosci. 2014; 6:51.
Cosín-Tomás M, Alvarez-López MJ, Sanchez-Roige S, Lalanza JF, Bayod S, Sanfeliu C, Pallàs M, Escorihuela RM, Kaliman P. PMID: 24688469; PMCID: PMC3960508.
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39
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Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task. Psychopharmacology (Berl). 2014 Jun; 231(12):2493-506.
Peña-Oliver Y, Sanchez-Roige S, Stephens DN, Ripley TL. PMID: 24402137.
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21 Fields:
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Animals
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Wnt pathway regulation by long-term moderate exercise in rat hippocampus. Brain Res. 2014 Jan 16; 1543:38-48.
Bayod S, Mennella I, Menella I, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Camins A, Pallàs M, Canudas AM. PMID: 24183784.
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PubMed Mentions:
33 Fields:
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AnimalsCells
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Long-term exercise modulates hippocampal gene expression in senescent female mice. J Alzheimers Dis. 2013; 33(4):1177-90.
Alvarez-López MJ, Castro-Freire M, Cosín-Tomás M, Sanchez-Roige S, Lalanza JF, Del Valle J, Párrizas M, Camins A, Pallás M, Escorihuela RM, Kaliman P. PMID: 23168450.
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23 Fields:
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Animals
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Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues. Exp Gerontol. 2012 Dec; 47(12):925-35.
Bayod S, Del Valle J, Lalanza JF, Sanchez-Roige S, de Luxán-Delgado B, Coto-Montes A, Canudas AM, Camins A, Escorihuela RM, Pallàs M. PMID: 22940286.
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33 Fields:
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AnimalsCells
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Physiological and behavioural consequences of long-term moderate treadmill exercise. Psychoneuroendocrinology. 2012 Nov; 37(11):1745-54.
Lalanza JF, Sanchez-Roige S, Gagliano H, Fuentes S, Bayod S, Camins A, Pallàs M, Armario A, Escorihuela RM. PMID: 22472479.
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PubMed Mentions:
13 Fields:
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Animals
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Measuring impulsivity in mice: the five-choice serial reaction time task. Psychopharmacology (Berl). 2012 Jan; 219(2):253-70.
Sanchez-Roige S, Peña-Oliver Y, Stephens DN. PMID: 22089700.
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28 Fields:
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AnimalsCells
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Long-term treadmill exercise induces neuroprotective molecular changes in rat brain. J Appl Physiol (1985). 2011 Nov; 111(5):1380-90.
Bayod S, Del Valle J, Canudas AM, Lalanza JF, Sanchez-Roige S, Camins A, Escorihuela RM, Pallàs M. PMID: 21817108.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells