Alexandra Sanchez Roige

Title(s)Associate Professor In Residence, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-6137-5699 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University Autonomous of Barcelona, Barcelona (Spain)BSc08/2009Psychology
    University Autonomous of Barcelona, Barcelona (Spain)MSc08/2010Psychology
    University of Sussex, Sussex (UK)PhD12/2014Neuroscience
    University of Sussex, Sussex (UK)Postdoctoral12/2015Neuroscience
    University of California San Diego, La Jolla (US)Postdoctoral03/2019Genetics
    University of California San Diego, La Jolla (US)Assistant ProfessorCurrentGenetics
    University of California San Diego, La Jolla (US)2023Senior Faculty Mentor Training
    University of California San Diego, La Jolla (US)Associate Professor04/2022Genetics

    Collapse Overview 
    Collapse Overview
    I am an Associate Professor at the Department of Psychiatry at the University of California San Diego (UCSD), and the Department of Medicine, Division of Genetic Medicine at Vanderbilt University Medical Center (VUMC). I have been working in the area of psychiatric genetics, and particularly substance use disorders, for over 15 years. I currently have 71 publications, published in top tier journals (Nature Genetics, Nature Neuroscience, American Journal of Psychiatry, Biological Psychiatry, Molecular Psychiatry), and I am an active member of many professional societies and international consortiums (PsycheMERGE, Externalizing, Latin American Genomics Consortium, Psychiatric Genomics Consortium). My work is focused on understanding causal factors contributing to psychiatric disorders, particularly substance use disorders and conditions characterized by high levels of impulsivity. In the past, I used behavioral and pharmacological experiments and molecular analysis to address this question, with special emphasis on translational validity to human studies. My current research focuses on the quantitative analysis of complex traits in humans using data from industry partners and academic initiatives, and translating some of the research findings in mouse and rat models. In parallel, I also use big data and high-throughput phenotyping to advance precision medicine by using electronic health records, leveraging access to one of the largest biobanks in the US from VUMC (BioVU) and collaborations within members of the PsycheMERGE consortium. Since becoming faculty at UCSD, I received a total of 10 grants (7 active, 3 closed; 6 as sole PI) in a 3 year-period (2019-2022), totaling >$4.3M (direct costs). Over the next decade, I seek to integrate the oceans of data generated (and continually expanding!) by human genetics research with data from electronic health records and model organisms, with the goal of furthering our biological understanding of psychiatric disorders and bringing the most promising results to the clinic.
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    Collapse Research Activities and Funding
    Genome-wide association analyses of nicotine behaviors in over 4 million individuals
    Tobacco-Related Disease Research Program Jun 1, 2022 - Jul 31, 2026
    Description: The goal of this project to apply innovative multivariate genomic techniques to increase sample, diversity and phenotypic resolution for tobacco use disorder gene discovery.
    Building bridges to allow cross-species translational genetics for the study of addiction
    NIH/NIDA 1DP1DA054394-01Sep 1, 2021 - Aug 31, 2026
    Role: PI
    Description: The goal of this project is to develop a toolkit for making cross-species integration a routine task; such framework should enable a follow-up of genetic association results with multi-omics investigations of molecular mechanisms, to facilitate their clinical translation and improve diagnosis, monitoring and treatment of addiction.
    Elucidating the genetic basis of nicotine dependence by using electronic health records
    Tobacco-Related Disease Research Program T29KT0526Apr 1, 2019 - Mar 31, 2022
    Role: PI
    Description: The goal of this project is to apply algorithms to identify individuals with nicotine dependence, and use genome-wide association analyses and polygenic methods to identify novel genetic variants associated with tobacco use disorders.
    CADM2, a cell adhesion molecule, and its association with risk and psychopathology
    Brain and Behavior Research Foundation NARSAD27676Jan 15, 2019 - Jan 14, 2021
    Role: PI
    Description: The goal of this project is to elucidate the molecular mechanisms whereby dysregulated synapse transmission causes impulsive behavior using a conditional CAMD2 knockout mouse line.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting. Genes Brain Behav. 2022 04; 21(4):e12800. Sanchez-Roige S, Barnes SA, Mallari J, Wood R, Polesskaya O, Palmer AA. PMID: 35243767; PMCID: PMC9211103.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    2. Evaluation of delay discounting as a transdiagnostic research domain criteria indicator in 1388 general community adults. Psychol Med. 2023 03; 53(4):1649-1657. Levitt EE, Oshri A, Amlung M, Ray LA, Sanchez-Roige S, Palmer AA, MacKillop J. PMID: 35080193; PMCID: PMC10009385.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    3. Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry. Mol Psychiatry. 2021 11; 26(11):6209-6217. Sanchez-Roige S, Fontanillas P, Jennings MV, Bianchi SB, Huang Y, Hatoum AS, Sealock J, Davis LK, Elson SL, 23andMe Research Team, Palmer AA. PMID: 34728798; PMCID: PMC8562028.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    4. Two data-driven approaches to identifying the spectrum of problematic opioid use: A pilot study within a chronic pain cohort. Int J Med Inform. 2021 12; 156:104621. Schirle L, Jeffery A, Yaqoob A, Sanchez-Roige S, Samuels DC. PMID: 34673309; PMCID: PMC8609775.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    5. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nat Neurosci. 2021 10; 24(10):1367-1376. Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. PMID: 34446935; PMCID: PMC8484054.
      View in: PubMed   Mentions: 120     Fields:    Translation:Humans
    6. Dimensional Phenotypes in Psychiatric Genetics: Lessons from Genome-Wide Association Studies of Alcohol Use Phenotypes. Complex Psychiatry. 2021 Dec; 7(3-4):45-48. Mallard TT, Sanchez-Roige S. PMID: 35083441; PMCID: PMC8739983.
      View in: PubMed   Mentions: 7  
    7. Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. Behav Genet. 2021 09; 51(5):543-558. Kuo SI, Salvatore JE, Barr PB, Aliev F, Anokhin A, Bucholz KK, Chan G, Edenberg HJ, Hesselbrock V, Kamarajan C, Kramer JR, Lai D, Mallard TT, Nurnberger JI, Pandey G, Plawecki MH, Sanchez-Roige S, Waldman I, Palmer AA, Externalizing Consortium, Dick DM. PMID: 34117972; PMCID: PMC8403154.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    8. Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. Am J Psychiatry. 2022 Jan; 179(1):58-70. Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA, Sanchez-Roige S. PMID: 33985350; PMCID: PMC9272895.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    9. Integration of evidence across human and model organism studies: A meeting report. Genes Brain Behav. 2021 Apr 23; e12738. Palmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca-Bachman CE, Parker CC, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, Lai D, Quach BC, Gaddis NC, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez-Roige S, Bandrowski A, Lu Q, Shen L, Philip V, Gelernter J, Bierut LJ, Hancock DB, Edenberg HJ, Johnson EO, Nestler EJ, Barr PB, Prins P, Smith DJ, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobson D, Palmer AA, Miles M, Chesler EJ, Emerson J, Agrawal A, Martone M, Williams RW. PMID: 33893716; PMCID: PMC8365690.
      View in: PubMed   Mentions: 8     Fields:    
    10. Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence. Drug Alcohol Depend. 2021 04 01; 221:108612. Sanchez-Roige S, Cox NJ, Johnson EO, Hancock DB, Davis LK. PMID: 33631543; PMCID: PMC8026738.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    11. A large-scale genome-wide association study meta-analysis of cannabis use disorder. Lancet Psychiatry. 2020 12; 7(12):1032-1045. Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, Reginsson GW, Zhou H, He J, Baranger DAA, Gudbjartsson DF, Wedow R, Adkins DE, Adkins AE, Alexander J, Bacanu SA, Bigdeli TB, Boden J, Brown SA, Bucholz KK, Bybjerg-Grauholm J, Corley RP, Degenhardt L, Dick DM, Domingue BW, Fox L, Goate AM, Gordon SD, Hack LM, Hancock DB, Hartz SM, Hickie IB, Hougaard DM, Krauter K, Lind PA, McClintick JN, McQueen MB, Meyers JL, Montgomery GW, Mors O, Mortensen PB, Nordentoft M, Pearson JF, Peterson RE, Reynolds MD, Rice JP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Tarter RE, Tyrfingsson T, Wall TL, Webb BT, Werge T, Wetherill L, Wright MJ, Zellers S, Adams MJ, Bierut LJ, Boardman JD, Copeland WE, Farrer LA, Foroud TM, Gillespie NA, Grucza RA, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono WG, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Madden PAF, Maes HH, Maher BS, Martin NG, McGue M, McIntosh AM, Medland SE, Nelson EC, Porjesz B, Riley BP, Stallings MC, Vanyukov MM, Vrieze S, Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Davis LK, Bogdan R, Gelernter J, Edenberg HJ, Stefansson K, Børglum AD, Agrawal A. PMID: 33096046; PMCID: PMC7674631.
      View in: PubMed   Mentions: 148     Fields:    Translation:Humans
    12. The Latent Genetic Structure of Impulsivity and Its Relation to Internalizing Psychopathology. Psychol Sci. 2020 08; 31(8):1025-1035. Gustavson DE, Friedman NP, Fontanillas P, Elson SL, 23andMe Research Team, Palmer AA, Sanchez-Roige S. PMID: 32716714; PMCID: PMC7427138.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    13. Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nat Neurosci. 2020 07; 23(7):809-818. Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. PMID: 32451486; PMCID: PMC7485556.
      View in: PubMed   Mentions: 167     Fields:    Translation:Humans
    14. Emerging phenotyping strategies will advance our understanding of psychiatric genetics. Nat Neurosci. 2020 04; 23(4):475-480. Sanchez-Roige S, Palmer AA. PMID: 32231337; PMCID: PMC9200410.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    15. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addict Biol. 2021 01; 26(1):e12880. Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, Yilmaz Z, Baker JH, Hübel C, Gordon S, Medland SE, Watson HJ, Gaspar HA, Bryois J, Hinney A, Leppä VM, Mattheisen M, Ripke S, Yao S, Giusti-Rodríguez P, Hanscombe KB, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Berrettini WH, Boehm I, Boni C, Boraska Perica V, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter MM, Fischer K, Föcker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Gratacos Mayora M, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op't Landt MCT, Slopien A, Sorbi S, Swiatkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell J, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Grove J, Henders AK, Larsen JT, Parker R, Petersen LV, Jordan J, Kennedy MA, Birgegård A, Lichtenstein P, Norring C, Landén M, Mortensen PB, Polimanti R, McClintick JN, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Degenhardt F, Docherty AR, Edwards AC, Foo JC, Fox L, Frank J, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Hodgkinson C, Hoffmann P, Hottenga JJ, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Peterson RE, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Zhou H, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Frye MA, Gäebel W, Hayward C, Ising M, Keyes M, Kiefer F, Koller G, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt SH, Wodarz N, Zill P, Adkins DE, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Costello EJ, de Wit H, Diazgranados N, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Hesselbrock V, Hewitt JK, Hopfer CJ, Iacono WG, Johnson EO, Karpyak VM, Kendler KS, et al. PMID: 32064741; PMCID: PMC7429266.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    16. Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples. Psychol Med. 2021 05; 51(7):1147-1156. Johnson EC, Sanchez-Roige S, Acion L, Adams MJ, Bucholz KK, Chan G, Chao MJ, Chorlian DB, Dick DM, Edenberg HJ, Foroud T, Hayward C, Heron J, Hesselbrock V, Hickman M, Kendler KS, Kinreich S, Kramer J, Kuo SI, Kuperman S, Lai D, McIntosh AM, Meyers JL, Plawecki MH, Porjesz B, Porteous D, Schuckit MA, Su J, Zang Y, Palmer AA, Agrawal A, Clarke TK, Edwards AC. PMID: 31955720; PMCID: PMC7405725.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    17. Steep Discounting of Future Rewards as an Impulsivity Phenotype: A Concise Review. Curr Top Behav Neurosci. 2020; 47:113-138. Levitt E, Sanchez-Roige S, Palmer AA, MacKillop J. PMID: 32236897.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    18. Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness. Hum Mol Genet. 2019 11 15; 28(22):3853-3865. Abdellaoui A, Sanchez-Roige S, Sealock J, Treur JL, Dennis J, Fontanillas P, Elson S, 23andme Research Team, Nivard MG, Ip HF, van der Zee M, Baselmans BML, Hottenga JJ, Willemsen G, Mosing M, Lu Y, Pedersen NL, Denys D, Amin N, M van Duijn C, Szilagyi I, Tiemeier H, Neumann A, Verweij KJH, Cacioppo S, Cacioppo JT, Davis LK, Palmer AA, Boomsma DI. PMID: 31518406; PMCID: PMC6935385.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    19. Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse. Biol Psychiatry. 2020 04 01; 87(7):609-618. Sanchez-Roige S, Palmer AA, Clarke TK. PMID: 31733789; PMCID: PMC7071963.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    20. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability. Nat Neurosci. 2019 Jul; 22(7):1196. Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, 23andMe Research Team, de Wit H, Davis LK, MacKillop J, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. PMID: 31168101.
      View in: PubMed   Mentions: 4     Fields:    
    21. Genomic basis of delayed reward discounting. Behav Processes. 2019 May; 162:157-161. Gray JC, Sanchez-Roige S, de Wit H, MacKillop J, Palmer AA. PMID: 30876880; PMCID: PMC6980721.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    22. Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2019 Mar; 22(3):503. Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 30622366.
      View in: PubMed   Mentions:    Fields:    
    23. Electronic Health Records Are the Next Frontier for the Genetics of Substance Use Disorders. Trends Genet. 2019 05; 35(5):317-318. Sanchez-Roige S, Palmer AA. PMID: 30797598; PMCID: PMC6984003.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    24. Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the CACNA1I and CADM2 genes. J Neurosci. 2019 03 27; 39(13):2562-2572. Sanchez-Roige S, Fontanillas P, Elson SL, Gray JC, de Wit H, MacKillop J, Palmer AA. PMID: 30718321; PMCID: PMC6435820.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    25. Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nat Genet. 2019 02; 51(2):245-257. Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A, Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F, 23and Me Research Team, eQTLgen Consortium, International Cannabis Consortium, Social Science Genetic Association Consortium, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP. PMID: 30643258; PMCID: PMC6713272.
      View in: PubMed   Mentions: 288     Fields:    Translation:Humans
    26. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018 12; 21(12):1656-1669. Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, 23andMe Research Team, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A. PMID: 30482948; PMCID: PMC6430207.
      View in: PubMed   Mentions: 315     Fields:    Translation:Humans
    27. Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. Am J Psychiatry. 2019 02 01; 176(2):107-118. Sanchez-Roige S, Palmer AA, Fontanillas P, Elson SL, 23andMe Research Team, the Substance Use Disorder Working Group of the Psychiatric Genomics Consorti, Adams MJ, Howard DM, Edenberg HJ, Davies G, Crist RC, Deary IJ, McIntosh AM, Clarke TK. PMID: 30336701; PMCID: PMC6365681.
      View in: PubMed   Mentions: 194     Fields:    Translation:Humans
    28. Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. Exp Clin Psychopharmacol. 2019 Feb; 27(1):29-37. MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA, de Wit H. PMID: 30265060; PMCID: PMC6908809.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci. 2018 09; 21(9):1161-1170. Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, 23andMe Research Team, de Wit H, Davis LK, MacKillop J, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. PMID: 30150663; PMCID: PMC6386176.
      View in: PubMed   Mentions: 214     Fields:    Translation:Humans
    30. Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 Jul; 21(7):1018. Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 29752479.
      View in: PubMed   Mentions:    Fields:    
    31. The genetics of human personality. Genes Brain Behav. 2018 03; 17(3):e12439. Sanchez-Roige S, Gray JC, MacKillop J, Chen CH, Palmer AA. PMID: 29152902; PMCID: PMC7012279.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    32. Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 01; 21(1):16-18. Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 29230059; PMCID: PMC6984001.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    33. Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. Addict Biol. 2019 01; 24(1):121-131. Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA. PMID: 29058377; PMCID: PMC6988186.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansPHPublic Health
    34. Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation. Neuropsychopharmacology. 2017 Mar; 42(4):811-821. Gao J, Davis LK, Hart AB, Sanchez-Roige S, Han L, Cacioppo JT, Palmer AA. PMID: 27629369; PMCID: PMC5312064.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    35. Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol Intake. Alcohol Clin Exp Res. 2016 10; 40(10):2208-2217. Sanchez-Roige S, Stephens DN, Duka T. PMID: 27565012.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    36. Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse. Front Genet. 2016; 7:52. Peña-Oliver Y, Carvalho FM, Sanchez-Roige S, Quinlan EB, Jia T, Walker-Tilley T, Rulten SL, Pearl FM, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Conrod PJ, Flor H, Gallinat J, Garavan H, Heinz A, Gowland P, Paillere Martinot ML, Paus T, Rietschel M, Robbins TW, Smolka MN, Schumann G, Stephens DN, IMAGEN Consortium. PMID: 27092175; PMCID: PMC4823271.
      View in: PubMed   Mentions: 12  
    37. Long-term moderate treadmill exercise promotes stress-coping strategies in male and female rats. Sci Rep. 2015 Nov 05; 5:16166. Lalanza JF, Sanchez-Roige S, Cigarroa I, Gagliano H, Fuentes S, Armario A, Capdevila L, Escorihuela RM. PMID: 26538081; PMCID: PMC4633642.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    38. The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice. Psychopharmacology (Berl). 2015 Sep; 232(18):3431-41. Ripley TL, Sanchez-Roige S, Bullmore ET, Mugnaini M, Maltby K, Miller SR, Wille DR, Nathan P, Stephens DN. PMID: 26141191; PMCID: PMC4537503.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    39. Alleviating waiting impulsivity and perseverative responding by μ-opioid receptor antagonism in two inbred mouse strains. Psychopharmacology (Berl). 2015 Apr; 232(8):1483-92. Sanchez-Roige S, Ripley TL, Stephens DN. PMID: 25381183.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    40. Repeated ethanol exposure during early and late adolescence: double dissociation of effects on waiting and choice impulsivity. Alcohol Clin Exp Res. 2014 Oct; 38(10):2579-89. Sanchez-Roige S, Peña-Oliver Y, Ripley TL, Stephens DN. PMID: 25346503.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    41. Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence. Age (Dordr). 2014; 36(5):9697. Sanchez-Roige S, Lalanza JF, Alvarez-López MJ, Cosín-Tomás M, Griñan-Ferré C, Pallàs M, Kaliman P, Escorihuela RM. PMID: 25129573; PMCID: PMC4159468.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    42. Voluntary exercise promotes beneficial anti-aging mechanisms in SAMP8 female brain. J Mol Neurosci. 2015 Feb; 55(2):525-32. Bayod S, Guzmán-Brambila C, Sanchez-Roige S, Lalanza JF, Kaliman P, Ortuño-Sahagun D, Escorihuela RM, Pallàs M. PMID: 25027560.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    43. Exaggerated waiting impulsivity associated with human binge drinking, and high alcohol consumption in mice. Neuropsychopharmacology. 2014 Dec; 39(13):2919-27. Sanchez-Roige S, Baro V, Trick L, Peña-Oliver Y, Stephens DN, Duka T. PMID: 24947901; PMCID: PMC4229569.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    44. Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues. J Physiol Pharmacol. 2014 Apr; 65(2):229-39. Bayod S, Del Valle J, Pelegri C, Vilaplana J, Canudas AM, Camins A, Jimenez A, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Pallas M. PMID: 24781732.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    45. Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise. Front Aging Neurosci. 2014; 6:51. Cosín-Tomás M, Alvarez-López MJ, Sanchez-Roige S, Lalanza JF, Bayod S, Sanfeliu C, Pallàs M, Escorihuela RM, Kaliman P. PMID: 24688469; PMCID: PMC3960508.
      View in: PubMed   Mentions: 35  
    46. Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task. Psychopharmacology (Berl). 2014 Jun; 231(12):2493-506. Peña-Oliver Y, Sanchez-Roige S, Stephens DN, Ripley TL. PMID: 24402137.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    47. Wnt pathway regulation by long-term moderate exercise in rat hippocampus. Brain Res. 2014 Jan 16; 1543:38-48. Bayod S, Mennella I, Menella I, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Camins A, Pallàs M, Canudas AM. PMID: 24183784.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    48. Long-term exercise modulates hippocampal gene expression in senescent female mice. J Alzheimers Dis. 2013; 33(4):1177-90. Alvarez-López MJ, Castro-Freire M, Cosín-Tomás M, Sanchez-Roige S, Lalanza JF, Del Valle J, Párrizas M, Camins A, Pallás M, Escorihuela RM, Kaliman P. PMID: 23168450.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    49. Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues. Exp Gerontol. 2012 Dec; 47(12):925-35. Bayod S, Del Valle J, Lalanza JF, Sanchez-Roige S, de Luxán-Delgado B, Coto-Montes A, Canudas AM, Camins A, Escorihuela RM, Pallàs M. PMID: 22940286.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    50. Physiological and behavioural consequences of long-term moderate treadmill exercise. Psychoneuroendocrinology. 2012 Nov; 37(11):1745-54. Lalanza JF, Sanchez-Roige S, Gagliano H, Fuentes S, Bayod S, Camins A, Pallàs M, Armario A, Escorihuela RM. PMID: 22472479.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    51. Measuring impulsivity in mice: the five-choice serial reaction time task. Psychopharmacology (Berl). 2012 Jan; 219(2):253-70. Sanchez-Roige S, Peña-Oliver Y, Stephens DN. PMID: 22089700.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    52. Long-term treadmill exercise induces neuroprotective molecular changes in rat brain. J Appl Physiol (1985). 2011 Nov; 111(5):1380-90. Bayod S, Del Valle J, Canudas AM, Lalanza JF, Sanchez-Roige S, Camins A, Escorihuela RM, Pallàs M. PMID: 21817108.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
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