Kellie Church

Title(s)	Associate Adjunct Professor, Ob/Gyn & Reproductive sciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
ORCID	0002-7522-299X
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Biography

Education and Training

UC Davis, Davis, CA	BS	06/1997	Animal Science
UC Davis, Davis, CA	MS	06/1999	Animal Science
University of Michigan, Ann Arbor, MI	PhD	06/2004	Molecular & Integrative Physiology
UC San Diego, La Jolla, CA	Postdoc	03/2011	Reproductive Medicine

Overview

The overarching goal of the Breen Church Laboratory is to understand the development, organization and activation of neural circuits that control reproductive neuroendocrine hormone activity in males and females in both normal physiologic conditions and in conditions of disrupted homeostasis, also known as stress.

Interests

Neuroscience, Stress, Hormones and Behavior

Websites

Breen Church Lab

Research

Research Activities and Funding

Stressed or Stressed Out: The Conference on Mechanisms of Allostasis
NIH R13MH131327Sep 1, 2022 - Aug 31, 2023
Role: PI

Regulation of gonadotropin secretion during undernutrition by a brainstem-hypothalamic neural pathway
NIH R01HD103725Sep 30, 2021 - Aug 31, 2025
Role: PI

Neural Mechanisms for Stress-Induced Diabetes Development
NIH P30DK0634915Jul 1, 2021 - Jun 30, 2024
Role: Pilot Project PI

Transcriptomic and epigenomic basis for reproductive dysfunction during stress
NIH R21HD105103May 1, 2021 - Apr 30, 2023
Role: PI

Neuroendocrine Regulation of Reproduction by Glucocorticoids
NIH R01HD086100Aug 10, 2016 - Mar 31, 2021
Role: PI

The Role of Gonadotrope in Stress-Induced Reproductive Impairment
NIH R00HD060947Apr 26, 2010 - Jan 31, 2017
Role: PI

The Role of Gonadotrope in Stress-Induced Reproductive Impairment
NIH K99HD060947Apr 26, 2010 - Jan 31, 2013
Role: PI

Reproductive Suppression by Cortisol at Pituitary Gland
NIH F32HD051360Aug 1, 2005 - Sep 30, 2008
Role: PI

Featured Content

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Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Allostasis in Neuroendocrine Systems Controlling Reproduction. Endocrinology. 2023 Aug 28; 164(10). Carrasco RA, Breen KM. PMID: 37586095; PMCID: PMC10461221.

View in: PubMed Mentions: 1 Fields:
End Endocrinology
Translation:Animals
A Modified Ultra-Sensitive ELISA for Measurement of LH in Mice. Endocrinology. 2022 09 01; 163(9). Kreisman MJ, McCosh RB, Breen KM. PMID: 35869782; PMCID: PMC9337274.

View in: PubMed Mentions: 4 Fields:
End Endocrinology
Translation:Animals
Regulation of the gonadotropin-releasing hormone neuron during stress. J Neuroendocrinol. 2022 05; 34(5):e13098. McCosh RB, O'Bryne KT, Karsch FJ, Breen KM. PMID: 35128742; PMCID: PMC9232848.

View in: PubMed Mentions: 7 Fields:
End Endocrinology Neu Neurology
Translation:Humans Cells
Neuroendocrine Basis for Disrupted Ovarian Cyclicity in Female Mice During Chronic Undernutrition. Endocrinology. 2021 08 01; 162(8). Kreisman MJ, Tadrousse KS, McCosh RB, Breen KM. PMID: 34037744; PMCID: PMC8272537.

View in: PubMed Mentions: 5 Fields:
End Endocrinology
Translation:Animals
Peripheral interleukin-1β inhibits arcuate kiss1 cells and LH pulses in female mice. J Endocrinol. 2020 08; 246(2):149-160. Makowski KN, Kreisman MJ, McCosh RB, Raad AA, Breen KM. PMID: 32464599; PMCID: PMC7371262.

View in: PubMed Mentions: 8 Fields:
End Endocrinology
Translation:Animals
Insulin-induced hypoglycaemia suppresses pulsatile luteinising hormone secretion and arcuate Kiss1 cell activation in female mice. J Neuroendocrinol. 2019 12; 31(12):e12813. McCosh RB, Kreisman MJ, Tian K, Ho BS, Thackray VG, Breen KM. PMID: 31758872; PMCID: PMC6933080.

View in: PubMed Mentions: 9 Fields:
End Endocrinology Neu Neurology
Translation:Animals Cells
Neural and endocrine mechanisms underlying stress-induced suppression of pulsatile LH secretion. Mol Cell Endocrinol. 2019 12 01; 498:110579. McCosh RB, Breen KM, Kauffman AS. PMID: 31521706; PMCID: PMC6874223.

View in: PubMed Mentions: 17 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals
Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice. Neuroendocrinology. 2020; 110(6):501-516. Kreisman MJ, McCosh RB, Tian K, Song CI, Breen KM. PMID: 31461711; PMCID: PMC7048652.

View in: PubMed Mentions: 17 Fields:
End Endocrinology Neu Neurology
Translation:Animals
Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion. J Vis Exp. 2018 07 04; (137). McCosh RB, Kreisman MJ, Breen KM. PMID: 30035764; PMCID: PMC6102042.

View in: PubMed Mentions: 12 Fields:
Bio Biology Med Medicine (General)
Translation:Animals
Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice. Endocrinology. 2017 11 01; 158(11):3716-3723. Yang JA, Song CI, Hughes JK, Kreisman MJ, Parra RA, Haisenleder DJ, Kauffman AS, Breen KM. PMID: 28973125; PMCID: PMC5695836.

View in: PubMed Mentions: 36 Fields:
End Endocrinology
Translation:Animals Cells
Androgens Mediate Sex-Dependent Gonadotropin Expression During Late Prenatal Development in the Mouse. Endocrinology. 2017 09 01; 158(9):2884-2894. Kreisman MJ, Song CI, Yip K, Natale BV, Natale DR, Breen KM. PMID: 28911172; PMCID: PMC5659668.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
Corticosterone Blocks Ovarian Cyclicity and the LH Surge via Decreased Kisspeptin Neuron Activation in Female Mice. Endocrinology. 2016 Mar; 157(3):1187-99. Luo E, Stephens SB, Chaing S, Munaganuru N, Kauffman AS, Breen KM. PMID: 26697722; PMCID: PMC4769373.

View in: PubMed Mentions: 31 Fields:
End Endocrinology
Translation:Animals Cells
A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. PMID: 26203175; PMCID: PMC4710190.

View in: PubMed Mentions: 81 Fields:
Rep Reproductive Medicine
Translation:Animals
Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Mol Endocrinol. 2014 Oct; 28(10):1640-55. Roybal LL, Hambarchyan A, Meadows JD, Barakat NH, Pepa PA, Breen KM, Mellon PL, Coss D. PMID: 25105693; PMCID: PMC4179627.

View in: PubMed Mentions: 11 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):71-7. Breen KM, Mellon PL. PMID: 24012628; PMCID: PMC3942370.

View in: PubMed Mentions: 13 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Phosphorylation of ATF2 and interaction with NFY induces c-Jun in the gonadotrope. Mol Cell Endocrinol. 2013 Jan 30; 365(2):316-26. Lindaman LL, Yeh DM, Xie C, Breen KM, Coss D. PMID: 23178797; PMCID: PMC3529762.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. Breen KM, Thackray VG, Hsu T, Mak-McCully RA, Coss D, Mellon PL. PMID: 22851703; PMCID: PMC3458227.

View in: PubMed Mentions: 22 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. Breen KM, Thackray VG, Coss D, Mellon PL. PMID: 20357224; PMCID: PMC2875819.

View in: PubMed Mentions: 10 Fields:
End Endocrinology
Translation:Animals Cells
The estrous cycle of the ewe is resistant to disruption by repeated, acute psychosocial stress. Biol Reprod. 2010 Jun; 82(6):1206-15. Wagenmaker ER, Breen KM, Oakley AE, Tilbrook AJ, Karsch FJ. PMID: 20164438; PMCID: PMC2874503.

View in: PubMed Mentions: 6 Fields:
Rep Reproductive Medicine
Translation:Animals
Glucocorticoids: do they really contribute to stress-related reproductive inhibition? Expert Rev Endocrinol Metab. 2009 Jul; 4(4):295-298. Karsch FJ, Breen KM. PMID: 30781279.

View in: PubMed Mentions: 1 Fields:
End Endocrinology Met Metabolism
Role of estradiol in cortisol-induced reduction of luteinizing hormone pulse frequency. Endocrinology. 2009 Jun; 150(6):2775-82. Oakley AE, Breen KM, Tilbrook AJ, Wagenmaker ER, Karsch FJ. PMID: 19179435; PMCID: PMC2689807.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
Translation:Animals
Cortisol interferes with the estradiol-induced surge of luteinizing hormone in the ewe. Biol Reprod. 2009 Mar; 80(3):458-63. Wagenmaker ER, Breen KM, Oakley AE, Pierce BN, Tilbrook AJ, Turner AI, Karsch FJ. PMID: 19056703; PMCID: PMC2805396.

View in: PubMed Mentions: 10 Fields:
Rep Reproductive Medicine
Translation:Animals
Psychosocial stress inhibits amplitude of gonadotropin-releasing hormone pulses independent of cortisol action on the type II glucocorticoid receptor. Endocrinology. 2009 Feb; 150(2):762-9. Wagenmaker ER, Breen KM, Oakley AE, Tilbrook AJ, Karsch FJ. PMID: 18832098; PMCID: PMC2646534.

View in: PubMed Mentions: 24 Fields:
End Endocrinology
Translation:Animals Cells
Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence of ovarian steroids. Endocrinology. 2009 Jan; 150(1):341-9. Oakley AE, Breen KM, Clarke IJ, Karsch FJ, Wagenmaker ER, Tilbrook AJ. PMID: 18801903; PMCID: PMC2630911.

View in: PubMed Mentions: 37 Fields:
End Endocrinology
Translation:Animals
Insight into the neuroendocrine site and cellular mechanism by which cortisol suppresses pituitary responsiveness to gonadotropin-releasing hormone. Endocrinology. 2008 Feb; 149(2):767-73. Breen KM, Davis TL, Doro LC, Nett TM, Oakley AE, Padmanabhan V, Rispoli LA, Wagenmaker ER, Karsch FJ. PMID: 17962347; PMCID: PMC2219297.

View in: PubMed Mentions: 18 Fields:
End Endocrinology
Translation:Animals Cells
Does cortisol acting via the type II glucocorticoid receptor mediate suppression of pulsatile luteinizing hormone secretion in response to psychosocial stress? Endocrinology. 2007 Apr; 148(4):1882-90. Breen KM, Oakley AE, Pytiak AV, Tilbrook AJ, Wagenmaker ER, Karsch FJ. PMID: 17204556.

View in: PubMed Mentions: 21 Fields:
End Endocrinology
Translation:Animals
Sex difference in the suppressive effect of cortisol on pulsatile secretion of luteinizing hormone in sheep. Endocrinology. 2006 Dec; 147(12):5921-31. Stackpole CA, Clarke IJ, Breen KM, Turner AI, Karsch FJ, Tilbrook AJ. PMID: 16959831.

View in: PubMed Mentions: 9 Fields:
End Endocrinology
Translation:Animals
New insights regarding glucocorticoids, stress and gonadotropin suppression. Front Neuroendocrinol. 2006 Jul; 27(2):233-45. Breen KM, Karsch FJ. PMID: 16712908.

View in: PubMed Mentions: 41 Fields:
End Endocrinology Neu Neurology
Translation:Animals
Does season alter responsiveness of the reproductive neuroendocrine axis to the suppressive actions of cortisol in ovariectomized ewes? Biol Reprod. 2006 Jan; 74(1):41-5. Breen KM, Karsch FJ. PMID: 16148215.

View in: PubMed Mentions: 5 Fields:
Rep Reproductive Medicine
Translation:Animals
Endocrine basis for disruptive effects of cortisol on preovulatory events. Endocrinology. 2005 Apr; 146(4):2107-15. Breen KM, Billings HJ, Wagenmaker ER, Wessinger EW, Karsch FJ. PMID: 15625239.

View in: PubMed Mentions: 44 Fields:
End Endocrinology
Translation:Animals
Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone? Endocrinology. 2004 Jun; 145(6):2739-46. Breen KM, Stackpole CA, Clarke IJ, Pytiak AV, Tilbrook AJ, Wagenmaker ER, Young EA, Karsch FJ. PMID: 15033919.

View in: PubMed Mentions: 10 Fields:
End Endocrinology
Translation:Animals
Does cortisol inhibit pulsatile luteinizing hormone secretion at the hypothalamic or pituitary level? Endocrinology. 2004 Feb; 145(2):692-8. Breen KM, Karsch FJ. PMID: 14576178.

View in: PubMed Mentions: 42 Fields:
End Endocrinology
Translation:Animals
Endotoxin inhibits the surge secretion of gonadotropin-releasing hormone via a prostaglandin-independent pathway. Endocrinology. 2004 Jan; 145(1):221-7. Breen KM, Billings HJ, Debus N, Karsch FJ. PMID: 14551234.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
Translation:Animals
Does cortisol mediate endotoxin-induced inhibition of pulsatile luteinizing hormone and gonadotropin-releasing hormone secretion? Endocrinology. 2002 Oct; 143(10):3748-58. Debus N, Breen KM, Barrell GK, Billings HJ, Brown M, Young EA, Karsch FJ. PMID: 12239084.

View in: PubMed Mentions: 19 Fields:
End Endocrinology
Translation:Animals
Mechanisms for ovarian cycle disruption by immune/inflammatory stress. Stress. 2002 Jun; 5(2):101-12. Karsch FJ, Battaglia DF, Breen KM, Debus N, Harris TG. PMID: 12186688.

View in: PubMed Mentions: 32 Fields:
Neu Neurology
Translation:Animals