Terence Hwa

Title(s)Professor, Physics
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Training Program in Quantitative Integrative Biology
    NIH T32GM127235Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Quantitative Studies of Metabolic Switches in enteric bacteria
    NIH R01GM109069Feb 17, 2014 - Jul 31, 2023
    Role: Principal Investigator
    Quantitative Studies of Bacterial Growth Physiology
    NIH R01GM095903Aug 1, 2011 - Feb 29, 2024
    Role: Principal Investigator
    Quantitative Characterization &Modeling of sRNA-Mediated Gene Regulation
    NIH R01GM077298May 1, 2007 - Apr 30, 2012
    Role: Principal Investigator
    Combinational Transcription Control in Bacteria
    NIH R21GM070915Apr 1, 2004 - Sep 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dynamic coexistence driven by physiological transitions in microbial communities. bioRxiv. 2024 Jan 12. Narla AV, Hwa T, Murugan A. PMID: 38260536; PMCID: PMC10802591.
      View in: PubMed   Mentions:
    2. Dynamic coexistence driven by physiological transitions in microbial communities. ArXiv. 2024 Jan 04. Narla AV, Hwa T, Murugan A. PMID: 38259349; PMCID: PMC10802671.
      View in: PubMed   Mentions:
    3. Inherited chitinases enable sustained growth and rapid dispersal of bacteria from chitin particles. Nat Microbiol. 2023 09; 8(9):1695-1705. Guessous G, Patsalo V, Balakrishnan R, Çaglar T, Williamson JR, Hwa T. PMID: 37580592.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    4. Functional decomposition of metabolism allows a system-level quantification of fluxes and protein allocation towards specific metabolic functions. Nat Commun. 2023 07 13; 14(1):4161. Mori M, Cheng C, Taylor BR, Okano H, Hwa T. PMID: 37443156; PMCID: PMC10345195.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria. Science. 2022 12 09; 378(6624):eabk2066. Balakrishnan R, Mori M, Segota I, Zhang Z, Aebersold R, Ludwig C, Hwa T. PMID: 36480614; PMCID: PMC9804519.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    6. Coordination of gene expression with cell size enables Escherichia coli to efficiently maintain motility across conditions. Proc Natl Acad Sci U S A. 2022 09 13; 119(37):e2110342119. Honda T, Cremer J, Mancini L, Zhang Z, Pilizota T, Hwa T. PMID: 36067284; PMCID: PMC9478672.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    7. Cellular perception of growth rate and the mechanistic origin of bacterial growth law. Proc Natl Acad Sci U S A. 2022 05 17; 119(20):e2201585119. Wu C, Balakrishnan R, Braniff N, Mori M, Manzanarez G, Zhang Z, Hwa T. PMID: 35544692; PMCID: PMC9171811.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    8. Suboptimal resource allocation in changing environments constrains response and growth in bacteria. Mol Syst Biol. 2021 12; 17(12):e10597. Balakrishnan R, de Silva RT, Hwa T, Cremer J. PMID: 34928547; PMCID: PMC8687047.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    9. A traveling-wave solution for bacterial chemotaxis with growth. Proc Natl Acad Sci U S A. 2021 11 30; 118(48). Narla AV, Cremer J, Hwa T. PMID: 34819366; PMCID: PMC8640786.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    10. Hierarchical and simultaneous utilization of carbon substrates: mechanistic insights, physiological roles, and ecological consequences. Curr Opin Microbiol. 2021 10; 63:172-178. Okano H, Hermsen R, Hwa T. PMID: 34365153.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    11. From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions. Mol Syst Biol. 2021 05; 17(5):e9536. Mori M, Zhang Z, Banaei-Esfahani A, Lalanne JB, Okano H, Collins BC, Schmidt A, Schubert OT, Lee DS, Li GW, Aebersold R, Hwa T, Ludwig C. PMID: 34032011; PMCID: PMC8144880.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    12. Regulation underlying hierarchical and simultaneous utilization of carbon substrates by flux sensors in Escherichia coli. Nat Microbiol. 2020 01; 5(1):206-215. Okano H, Hermsen R, Kochanowski K, Hwa T. PMID: 31819215; PMCID: PMC6925339.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    13. Chemotaxis as a navigation strategy to boost range expansion. Nature. 2019 11; 575(7784):658-663. Cremer J, Honda T, Tang Y, Wong-Ng J, Vergassola M, Hwa T. PMID: 31695195; PMCID: PMC6883170.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    14. Spatiotemporal establishment of dense bacterial colonies growing on hard agar. Elife. 2019 03 11; 8. Warren MR, Sun H, Yan Y, Cremer J, Li B, Hwa T. PMID: 30855227; PMCID: PMC6411370.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    15. Bacterial growth, flow, and mixing shape human gut microbiota density and composition. Gut Microbes. 2018 11 02; 9(6):559-566. Arnoldini M, Cremer J, Hwa T. PMID: 29533125; PMCID: PMC6287699.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    16. Slowdown of Translational Elongation in Escherichia coli under Hyperosmotic Stress. mBio. 2018 02 13; 9(1). Dai X, Zhu M, Warren M, Balakrishnan R, Okano H, Williamson JR, Fredrick K, Hwa T. PMID: 29440576; PMCID: PMC5821080.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    17. Quantifying the benefit of a proteome reserve in fluctuating environments. Nat Commun. 2017 10 31; 8(1):1225. Mori M, Schink S, Erickson DW, Gerland U, Hwa T. PMID: 29089487; PMCID: PMC5663898.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    18. A global resource allocation strategy governs growth transition kinetics of Escherichia coli. Nature. 2017 11 02; 551(7678):119-123. Erickson DW, Schink SJ, Patsalo V, Williamson JR, Gerland U, Hwa T. PMID: 29072300; PMCID: PMC5901684.
      View in: PubMed   Mentions: 82     Fields:    Translation:Cells
    19. Effect of water flow and chemical environment on microbiota growth and composition in the human colon. Proc Natl Acad Sci U S A. 2017 06 20; 114(25):6438-6443. Cremer J, Arnoldini M, Hwa T. PMID: 28588144; PMCID: PMC5488924.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    20. Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth. Nat Microbiol. 2016 Dec 12; 2:16231. Dai X, Zhu M, Warren M, Balakrishnan R, Patsalo V, Okano H, Williamson JR, Fredrick K, Wang YP, Hwa T. PMID: 27941827; PMCID: PMC5346290.
      View in: PubMed   Mentions: 137     Fields:    Translation:Cells
    21. Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11414-11419. Cremer J, Segota I, Yang CY, Arnoldini M, Sauls JT, Zhang Z, Gutierrez E, Groisman A, Hwa T. PMID: 27681630; PMCID: PMC5068270.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    22. Inflating bacterial cells by increased protein synthesis. Mol Syst Biol. 2015 Oct 30; 11(10):836. Basan M, Zhu M, Dai X, Warren M, Sévin D, Wang YP, Hwa T. PMID: 26519362; PMCID: PMC4631207.
      View in: PubMed   Mentions: 89     Fields:    Translation:Cells
    23. A growth-rate composition formula for the growth of E.coli on co-utilized carbon substrates. Mol Syst Biol. 2015 Apr 09; 11(4):801. Hermsen R, Okano H, You C, Werner N, Hwa T. PMID: 25862745; PMCID: PMC4422558.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    24. Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria. Mol Syst Biol. 2015 Feb 12; 11(1):784. Hui S, Silverman JM, Chen SS, Erickson DW, Basan M, Wang J, Hwa T, Williamson JR. PMID: 25678603; PMCID: PMC4358657.
      View in: PubMed   Mentions: 139     Fields:    Translation:Cells
    25. The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria. Science. 2013 Nov 29; 342(6162):1237435. Deris JB, Kim M, Zhang Z, Okano H, Hermsen R, Groisman A, Hwa T. PMID: 24288338; PMCID: PMC4059556.
      View in: PubMed   Mentions: 87     Fields:    Translation:Cells
    26. Coordination of bacterial proteome with metabolism by cyclic AMP signalling. Nature. 2013 Aug 15; 500(7462):301-6. You C, Okano H, Hui S, Zhang Z, Kim M, Gunderson CW, Wang YP, Lenz P, Yan D, Hwa T. PMID: 23925119; PMCID: PMC4038431.
      View in: PubMed   Mentions: 178     Fields:    Translation:Cells
    27. On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):10775-80. Hermsen R, Deris JB, Hwa T. PMID: 22711808; PMCID: PMC3390829.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    28. Genomics-aided structure prediction. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10340-5. Sulkowska JI, Morcos F, Weigt M, Hwa T, Onuchic JN. PMID: 22691493; PMCID: PMC3387073.
      View in: PubMed   Mentions: 103     Fields:    Translation:Cells
    29. Need-based activation of ammonium uptake in Escherichia coli. Mol Syst Biol. 2012; 8:616. Kim M, Zhang Z, Okano H, Yan D, Groisman A, Hwa T. PMID: 23010999; PMCID: PMC3472687.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    30. Direct-coupling analysis of residue coevolution captures native contacts across many protein families. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):E1293-301. Morcos F, Pagnani A, Lunt B, Bertolino A, Marks DS, Sander C, Zecchina R, Onuchic JN, Hwa T, Weigt M. PMID: 22106262; PMCID: PMC3241805.
      View in: PubMed   Mentions: 597     Fields:    Translation:Cells
    31. Speed, sensitivity, and bistability in auto-activating signaling circuits. PLoS Comput Biol. 2011 Nov; 7(11):e1002265. Hermsen R, Erickson DW, Hwa T. PMID: 22125482; PMCID: PMC3219618.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    32. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 01; 360(1):230-40. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. PMID: 21920356; PMCID: PMC3661008.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. Sources and sinks: a stochastic model of evolution in heterogeneous environments. Phys Rev Lett. 2010 Dec 10; 105(24):248104. Hermsen R, Hwa T. PMID: 21231560; PMCID: PMC4038430.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    34. Interdependence of cell growth and gene expression: origins and consequences. Science. 2010 Nov 19; 330(6007):1099-102. Scott M, Gunderson CW, Mateescu EM, Zhang Z, Hwa T. PMID: 21097934.
      View in: PubMed   Mentions: 561     Fields:    Translation:Cells
    35. Computational modeling of phosphotransfer complexes in two-component signaling. Methods Enzymol. 2010; 471:43-58. Schug A, Weigt M, Hoch JA, Onuchic JN, Hwa T, Szurmant H. PMID: 20946841.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    36. Growth rate-dependent global effects on gene expression in bacteria. Cell. 2009 Dec 24; 139(7):1366-75. Klumpp S, Zhang Z, Hwa T. PMID: 20064380; PMCID: PMC2818994.
      View in: PubMed   Mentions: 299     Fields:    Translation:Cells
    37. High-resolution protein complexes from integrating genomic information with molecular simulation. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22124-9. Schug A, Weigt M, Onuchic JN, Hwa T, Szurmant H. PMID: 20018738; PMCID: PMC2799721.
      View in: PubMed   Mentions: 68     Fields:    Translation:Cells
    38. Traffic patrol in the transcription of ribosomal RNA. RNA Biol. 2009 Sep-Oct; 6(4):392-4. Klumpp S, Hwa T. PMID: 19502817; PMCID: PMC2859892.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    39. Identification of direct residue contacts in protein-protein interaction by message passing. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):67-72. Weigt M, White RA, Szurmant H, Hoch JA, Hwa T. PMID: 19116270; PMCID: PMC2629192.
      View in: PubMed   Mentions: 400     Fields:    Translation:Cells
    40. Growth-rate-dependent partitioning of RNA polymerases in bacteria. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20245-50. Klumpp S, Hwa T. PMID: 19073937; PMCID: PMC2629260.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    41. Small RNAs establish gene expression thresholds. Curr Opin Microbiol. 2008 Dec; 11(6):574-9. Levine E, Hwa T. PMID: 18935980; PMCID: PMC2613760.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    42. Stochasticity and traffic jams in the transcription of ribosomal RNA: Intriguing role of termination and antitermination. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18159-64. Klumpp S, Hwa T. PMID: 19017803; PMCID: PMC2587539.
      View in: PubMed   Mentions: 53     Fields:    Translation:Cells
    43. An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13752-7. Liu J, Desai A, Onuchic JN, Hwa T. PMID: 18780795; PMCID: PMC2544526.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    44. A mechanobiochemical mechanism for monooriented chromosome oscillation in mitosis. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16104-9. Liu J, Desai A, Onuchic JN, Hwa T. PMID: 17911248; PMCID: PMC2042169.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    45. Quantitative characteristics of gene regulation by small RNA. PLoS Biol. 2007 Sep; 5(9):e229. Levine E, Zhang Z, Kuhlman T, Hwa T. PMID: 17713988; PMCID: PMC1994261.
      View in: PubMed   Mentions: 186     Fields:    Translation:Cells
    46. Stochastic fluctuations in metabolic pathways. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9224-9. Levine E, Hwa T. PMID: 17517669; PMCID: PMC1890476.
      View in: PubMed   Mentions: 54     Fields:    
    47. Deterministic characterization of stochastic genetic circuits. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7402-7. Scott M, Hwa T, Ingalls B. PMID: 17446275; PMCID: PMC1863463.
      View in: PubMed   Mentions: 28     Fields:    
    48. Combinatorial transcriptional control of the lactose operon of Escherichia coli. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):6043-8. Kuhlman T, Zhang Z, Saier MH, Hwa T. PMID: 17376875; PMCID: PMC1851613.
      View in: PubMed   Mentions: 121     Fields:    Translation:Cells
    49. Translocation of structured polynucleotides through nanopores. Phys Biol. 2004 Jun; 1(1-2):19-26. Gerland U, Bundschuh R, Hwa T. PMID: 16204818.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    50. Analytical study of the effect of recombination on evolution via DNA shuffling. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 May; 69(5 Pt 1):051911. Peng W, Levine H, Hwa T, Kessler DA. PMID: 15244851.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    51. Distinct changes of genomic biases in nucleotide substitution at the time of Mammalian radiation. Mol Biol Evol. 2003 Nov; 20(11):1887-96. Arndt PF, Petrov DA, Hwa T. PMID: 12885958.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    52. Mechanically probing the folding pathway of single RNA molecules. Biophys J. 2003 May; 84(5):2831-40. Gerland U, Bundschuh R, Hwa T. PMID: 12719217; PMCID: PMC1302848.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    53. On schemes of combinatorial transcription logic. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5136-41. Buchler NE, Gerland U, Hwa T. PMID: 12702751; PMCID: PMC404558.
      View in: PubMed   Mentions: 280     Fields:    Translation:Cells
    54. Localization of denaturation bubbles in random DNA sequences. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4411-6. Hwa T, Marinari E, Sneppen K, Tang LH. PMID: 12672955; PMCID: PMC404689.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    55. Dynamics of competitive evolution on a smooth landscape. Phys Rev Lett. 2003 Feb 28; 90(8):088103. Peng W, Gerland U, Hwa T, Levine H. PMID: 12633464.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    56. DNA sequence evolution with neighbor-dependent mutation. J Comput Biol. 2003; 10(3-4):313-22. Arndt PF, Burge CB, Hwa T. PMID: 12935330.
      View in: PubMed   Mentions: 45     Fields:    
    57. Physical constraints and functional characteristics of transcription factor-DNA interaction. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12015-20. Gerland U, Moroz JD, Hwa T. PMID: 12218191; PMCID: PMC129390.
      View in: PubMed   Mentions: 107     Fields:    
    58. Statistical mechanics of secondary structures formed by random RNA sequences. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Mar; 65(3 Pt 1):031903. Bundschuh R, Hwa T. PMID: 11909105.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    59. Expression patterns of cell-type-specific genes in Dictyostelium. Mol Biol Cell. 2001 Sep; 12(9):2590-600. Iranfar N, Fuller D, Sasik R, Hwa T, Laub M, Loomis WF. PMID: 11553701; PMCID: PMC59697.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    60. Percolation clustering: a novel approach to the clustering of gene expression patterns in Dictyostelium development. Pac Symp Biocomput. 2001; 335-47. Sásik R, Hwa T, Iranfar N, Loomis WF. PMID: 11262953.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    61. Optimizing Smith-Waterman alignments. Pac Symp Biocomput. 1999; 302-13. Olsen R, Hwa T, Lässig M. PMID: 10380206.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    62. Rapid assessment of extremal statistics for gapped local alignment. Proc Int Conf Intell Syst Mol Biol. 1999; 211-22. Olsen R, Bundschuh R, Hwa T. PMID: 10786304.
      View in: PubMed   Mentions: 18     Fields:    
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