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    Hal Hoffman

    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0760
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki Disease
      NIH/NHLBI R01HL140898Jan 1, 2018 - Nov 30, 2022
      Role: Co-Principal Investigator
      Sterile inflammation and pyroptotic cell death in liver fibrosis
      NIH/NIDDK R01DK113592Mar 1, 2017 - Feb 28, 2022
      Role: Co-Principal Investigator
      Transcriptional Control of Lung Macrophage Development
      NIH/NHLBI R01HL126703May 15, 2015 - Mar 31, 2019
      Role: Principal Investigator
      Targeting inflammasome mediated disorders with green tea
      NIH/NIAID R21AI090487Jun 15, 2010 - May 31, 2012
      Role: Principal Investigator
      Novel regulatory role of cryopyrin in inflammation
      NIH/NIAID R21AI061108Jul 1, 2004 - Jun 30, 2007
      Role: Principal Investigator
      The Role of Cryopyrin in Autoinflammatory Diseases
      NIH/NIAID R01AI052430Aug 1, 2002 - Jul 31, 2013
      Role: Principal Investigator
      NIH/NIAID K08AI001508Jan 1, 1998 - Dec 31, 2002
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hoffman H, Broderick L. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 Jul; 138(1):3-14. PMID: 27373321.
        View in: PubMed
      2. Hoffman H, Throne ML, Amar NJ, Cartwright RC, Kivitz AJ, Soo Y, Weinstein SP. Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72-week open-label extension study. Clin Ther. 2012 Oct; 34(10):2091-103. PMID: 23031624.
        View in: PubMed
      3. Hoffman H, Brydges SD. Genetic and molecular basis of inflammasome-mediated disease. J Biol Chem. 2011 Apr 01; 286(13):10889-96. PMID: 21296874; PMCID: PMC3064144.
      4. Hoffman H, Wanderer AA. Inflammasome and IL-1beta-mediated disorders. Curr Allergy Asthma Rep. 2010 Jul; 10(4):229-35. PMID: 20425006; PMCID: PMC2892083.
      5. Hoffman H. Therapy of autoinflammatory syndromes. J Allergy Clin Immunol. 2009 Dec; 124(6):1129-38; quiz 1139-40. PMID: 20004774; PMCID: PMC4508191.
      6. Hoffman H, Simon A. Recurrent febrile syndromes: what a rheumatologist needs to know. Nat Rev Rheumatol. 2009 May; 5(5):249-56. PMID: 19412191.
        View in: PubMed
      7. Hoffman H. Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS). Expert Opin Biol Ther. 2009 Apr; 9(4):519-31. PMID: 19344287.
        View in: PubMed
      8. Hoffman H, Wolfe F, Belomestnov P, Mellis SJ. Cryopyrin-associated periodic syndromes: development of a patient-reported outcomes instrument to assess the pattern and severity of clinical disease activity. Curr Med Res Opin. 2008 Sep; 24(9):2531-43. PMID: 18667113.
        View in: PubMed
      9. Hoffman H. Hereditary immunologic disorders caused by pyrin and cryopyrin. Curr Allergy Asthma Rep. 2007 Sep; 7(5):323-30. PMID: 17697637.
        View in: PubMed
      10. Hoffman H, Firestein GS. Anakinra for the treatment of neonatal-onset multisystem inflammatory disease. Nat Clin Pract Rheumatol. 2006 Dec; 2(12):646-7. PMID: 17133246.
        View in: PubMed
      11. Hoffman H, Rosengren S, Boyle DL, Cho JY, Nayar J, Mueller JL, Anderson JP, Wanderer AA, Firestein GS. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet. 2004 Nov 13-19; 364(9447):1779-85. PMID: 15541451; PMCID: PMC4321997.
      12. Hoffman H, Gregory SG, Mueller JL, Tresierras M, Broide DH, Wanderer AA, Kolodner RD. Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. Hum Genet. 2003 Feb; 112(2):209-16. PMID: 12522564.
        View in: PubMed
      13. Hoffman H, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet. 2001 Nov; 29(3):301-5. PMID: 11687797; PMCID: PMC4322000.
      14. Hoffman H, Bastian JF, Bird LM. Humoral immunodeficiency with facial dysmorphology and limb anomalies: a new syndrome. Clin Dysmorphol. 2001 Jan; 10(1):1-8. PMID: 11152140.
        View in: PubMed
      15. Hoffman H, Wright FA, Broide DH, Wanderer AA, Kolodner RD. Identification of a locus on chromosome 1q44 for familial cold urticaria. Am J Hum Genet. 2000 May; 66(5):1693-8. PMID: 10741953; PMCID: PMC1378006.