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    Flossie Wong-staal

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #9111E
    CA La Jolla 92093
    Phone858-552-8585
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      LENTIVIRAL VECTORS FOR HIV GENE THERAPY
      NIH/NIAID P01AI045992Aug 15, 1999 - Jul 31, 2004
      Role: Co-Principal Investigator
      CONFERENCE ON AIDS PATHOGENESIS
      NIH/NIAID R13AI043951Jan 1, 1999 - Dec 31, 1999
      Role: Principal Investigator
      RIBOZYME GENE THERAPY FOR CD4 AND CD34 CELLS
      NIH/NIDDK R01DK054675Sep 30, 1998 - Jul 31, 2003
      Role: Principal Investigator
      CELLULAR FACTORS INVOLVED IN NUCLEAR EXPORT OF VIRAL RNA
      NIH/NIGMS R01GM056089Jan 1, 1998 - Dec 31, 2001
      Role: Principal Investigator
      FACS VANTAGE CELL SORTER
      NIH/NCRR S10RR011852Feb 1, 1997 - Jun 30, 1998
      Role: Principal Investigator
      TRANSGENIC MICE MODEL FOR RIBOZYME EXPRESSION AND ACT
      NIH/FIC R03TW000678Apr 1, 1996 - Nov 30, 1999
      Role: Principal Investigator
      DEVELOPMENT OF GENE DELIVERY VECTOR
      NIH/NIAID U19AI036612Sep 1, 1994 - Feb 28, 2001
      Role: Principal Investigator
      RIBOZYME GENE THERAPY FOR CD4 AND CD34 CELLS
      NIH/NIDDK R01DK049618Aug 1, 1994 - Sep 30, 1998
      Role: Principal Investigator
      Center for AIDS Research
      NIH/NIAID P30AI036214Apr 1, 1994 - Mar 31, 2018
      Role: Co-Principal Investigator
      REV/REX TRANSACTIVATION PATHWAY OF HIV/HTLV
      NIH/NIAID R01AI031378Jul 1, 1991 - May 31, 1996
      Role: Principal Investigator
      HIV TAT PROTEIN AND KAPOSI'S SARCOMA PATHOGENESIS
      NIH/NCI R01CA052412Feb 1, 1991 - Jan 31, 1994
      Role: Principal Investigator
      IN VIVO AND IN VITRO PARAMETERS OF HIV-2 PATHOGENICITY
      NIH/NIAID R01AI029889Jul 1, 1990 - Jun 30, 1995
      Role: Principal Investigator
      STRATEGIES FOR HIV VACCINE DEVELOPMENT
      NIH/NIAID U01AI030238Jun 15, 1990 - Nov 30, 1996
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sulkowski MS, Kang M, Matining R, Wyles D, Johnson VA, Morse GD, Amorosa V, Bhattacharya D, Coughlin K, Wong-Staal F, Glesby MJ. Safety and Antiviral Activity of the HCV Entry Inhibitor ITX5061 in Treatment-Naive HCV-Infected Adults: A Randomized, Double-Blind, Phase 1b Study. J Infect Dis. 2014 Mar; 209(5):658-67. PMID: 24041792.
        View in: PubMed
      2. Mittapalli GK, Zhao F, Jackson A, Gao H, Lee H, Chow S, Kaur MP, Nguyen N, Zamboni R, McKelvy J, Wong-Staal F, Macdonald JE. Discovery of ITX 4520: a highly potent orally bioavailable hepatitis C virus entry inhibitor. Bioorg Med Chem Lett. 2012 Aug 1; 22(15):4955-61. PMID: 22784640.
        View in: PubMed
      3. Mittapalli GK, Jackson A, Zhao F, Lee H, Chow S, McKelvy J, Wong-Staal F, Macdonald JE. Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors. Bioorg Med Chem Lett. 2011 Nov 15; 21(22):6852-5. PMID: 21978675.
        View in: PubMed
      4. Brimacombe CL, Grove J, Meredith LW, Hu K, Syder AJ, Flores MV, Timpe JM, Krieger SE, Baumert TF, Tellinghuisen TL, Wong-Staal F, Balfe P, McKeating JA. Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. J Virol. 2011 Jan; 85(1):596-605. PMID: 20962076.
        View in: PubMed
      5. Syder AJ, Lee H, Zeisel MB, Grove J, Soulier E, Macdonald J, Chow S, Chang J, Baumert TF, McKeating JA, McKelvy J, Wong-Staal F. Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors. J Hepatol. 2011 Jan; 54(1):48-55. PMID: 20932595.
        View in: PubMed
      6. Fletcher NF, Yang JP, Farquhar MJ, Hu K, Davis C, He Q, Dowd K, Ray SC, Krieger SE, Neyts J, Baumert TF, Balfe P, McKeating JA, Wong-Staal F. Hepatitis C virus infection of neuroepithelioma cell lines. Gastroenterology. 2010 Oct; 139(4):1365-74. PMID: 20538002.
        View in: PubMed
      7. Zhou D, Zhang J, Wang C, Bliesath JR, He Q, Yu D, Li-He Z, Wong-Staal F. A method for detecting and preventing negative RNA interference in preparation of lentiviral vectors for siRNA delivery. RNA. 2009 Apr; 15(4):732-40. PMID: 19244361.
        View in: PubMed
      8. Yang JP, Zhou D, Wong-Staal F. Screening of small-molecule compounds as inhibitors of HCV entry. Methods Mol Biol. 2009; 510:295-304. PMID: 19009270.
        View in: PubMed
      9. Yu DH, Macdonald J, Liu G, Lee AS, Ly M, Davis T, Ke N, Zhou D, Wong-Staal F, Li QX. Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PLoS One. 2008; 3(12):e3951. PMID: 19079611.
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      10. He QS, Tang H, Zhang J, Truong K, Wong-Staal F, Zhou D. Comparisons of RNAi approaches for validation of human RNA helicase A as an essential factor in hepatitis C virus replication. J Virol Methods. 2008 Dec; 154(1-2):216-9. PMID: 18782589.
        View in: PubMed
      11. Li QX, Liu G, Wong-Staal F. Oncolytic virotherapy as a personalized cancer vaccine. Int J Cancer. 2008 Aug 1; 123(3):493-9. PMID: 18500742.
        View in: PubMed
      12. Falkenstein IA, Cheng L, Wong-Staal F, Tammewar AM, Barron EC, Silva GA, Li QX, Yu D, Hysell M, Liu G, Ke N, Macdonald JE, Freeman WR. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul; 33(7):599-609. PMID: 18600493.
        View in: PubMed
      13. Zhou D, Wang C, Zhang J, Bliesath J, He QS, Ke N, Yu D, Li Q, Zhang LH, Wong-Staal F. Generation of shRNA pool library: a revision of the biological technique from the viewpoint of chemistry. Chembiochem. 2008 Jun 16; 9(9):1365-7. PMID: 18435449.
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      14. Ke N, Ma H, Diedrich G, Chionis J, Liu G, Yu DH, Wong-Staal F, Li QX. Biochemical characterization of genetic mutations of GPR56 in patients with bilateral frontoparietal polymicrogyria (BFPP). Biochem Biophys Res Commun. 2008 Feb 8; 366(2):314-20. PMID: 18042463.
        View in: PubMed
      15. Liu G, Grifman M, Macdonald J, Moller P, Wong-Staal F, Li QX. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase. J Endocrinol. 2007 Sep; 194(3):569-78. PMID: 17761896.
        View in: PubMed
      16. Zhang J, Wang C, Ke N, Bliesath J, Chionis J, He QS, Li QX, Chatterton JE, Wong-Staal F, Zhou D. A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animals. RNA. 2007 Aug; 13(8):1375-83. PMID: 17616554.
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      17. Ke N, Sundaram R, Liu G, Chionis J, Fan W, Rogers C, Awad T, Grifman M, Yu D, Wong-Staal F, Li QX. Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway. Mol Cancer Ther. 2007 Jun; 6(6):1840-50. PMID: 17575113.
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      18. Li QX, Tan P, Ke N, Wong-Staal F. Ribozyme technology for cancer gene target identification and validation. Adv Cancer Res. 2007; 96:103-43. PMID: 17161678.
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      19. Yu DH, Macdonald J, Josephs S, Liu Q, Nguy V, Tor Y, Wong-Staal F, Li QX. MDDD, a 4,9-diazapyrenium derivative, is selectively toxic to glioma cells by inducing growth arrest at G0/G1 independently of p53. Invest New Drugs. 2006 Nov; 24(6):489-98. PMID: 16633716.
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      20. Ke N, Zhou D, Chatterton JE, Liu G, Chionis J, Zhang J, Tsugawa L, Lynn R, Yu D, Meyhack B, Wong-Staal F, Li QX. A new inducible RNAi xenograft model for assessing the staged tumor response to mTOR silencing. Exp Cell Res. 2006 Sep 10; 312(15):2726-34. PMID: 16765945.
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      21. Yang JP, Fan W, Rogers C, Chatterton JE, Bliesath J, Liu G, Ke N, Wang CY, Rhoades K, Wong-Staal F, Li QX. A novel RNAi library based on partially randomized consensus sequences of nuclear receptors: identifying the receptors involved in amyloid beta degradation. Genomics. 2006 Sep; 88(3):282-92. PMID: 16631344.
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      22. Kayikcioglu OR, Falkenstein I, Cheng L, Kozak I, La Bree L, Azen SP, Wong-Staal F, Paoni NF, Freeman WR. Therapy with ribozyme to the proliferating cell nuclear antigen-ribozyme and 5-fluorouracil of experimental choroidal neovascularization in rats. J Ocul Pharmacol Ther. 2006 Feb; 22(1):1-9. PMID: 16503769.
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      23. Yu DH, Fan W, Liu G, Nguy V, Chatterton JE, Long S, Ke N, Meyhack B, Bruengger A, Brachat A, Wong-Staal F, Li QX. PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. Exp Cell Res. 2006 Apr 1; 312(6):865-76. PMID: 16413018.
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      24. Zhou D, He QS, Wang C, Zhang J, Wong-Staal F. RNA interference and potential applications. Curr Top Med Chem. 2006; 6(9):901-11. PMID: 16787283.
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      25. Liu G, Wong-Staal F, Li QX. Recent development of RNAi in drug target discovery and validation. Drug Discov Today Technol. 2006; 3(3):293-300. PMID: 24980531.
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      26. Yu DH, Chatterton JE, Bliesath JR, Sundaram R, Ke N, Nguy V, Meyhack B, Wong-Staal F, Li QX. A 96-well surrogate survival assay coupled with a special short interfering RNA vector for assessing cancer gene targets with enhanced signal/noise ratio and its utility in HTS for cancer therapeutic targets. Assay Drug Dev Technol. 2005 Aug; 3(4):401-11. PMID: 16180995.
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      27. Waninger S, Kuhen K, Hu X, Chatterton JE, Wong-Staal F, Tang H. Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach. J Virol. 2004 Dec; 78(23):12829-37. PMID: 15542635.
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      28. Ke N, Claassen G, Yu DH, Albers A, Fan W, Tan P, Grifman M, Hu X, Defife K, Nguy V, Meyhack B, Brachat A, Wong-Staal F, Li QX. Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis. Cancer Res. 2004 Nov 15; 64(22):8208-12. PMID: 15548686.
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      29. Tetsuka T, Uranishi H, Sanda T, Asamitsu K, Yang JP, Wong-Staal F, Okamoto T. RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator. Eur J Biochem. 2004 Sep; 271(18):3741-51. PMID: 15355351.
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      30. Hu X, Hipolito S, Lynn R, Abraham V, Ramos S, Wong-Staal F. Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus. Nucleic Acids Res. 2004; 32(15):4609-17. PMID: 15333693.
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      31. Ke N, Albers A, Claassen G, Yu DH, Chatterton JE, Hu X, Meyhack B, Wong-Staal F, Li QX. One-week 96-well soft agar growth assay for cancer target validation. Biotechniques. 2004 May; 36(5):826-8, 830, 832-3. PMID: 15152603.
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      32. Kan-Mitchell J, Bisikirska B, Wong-Staal F, Schaubert KL, Bajcz M, Bereta M. The HIV-1 HLA-A2-SLYNTVATL is a help-independent CTL epitope. J Immunol. 2004 May 1; 172(9):5249-61. PMID: 15100263.
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      33. Smith WA, Schurter BT, Wong-Staal F, David M. Arginine methylation of RNA helicase a determines its subcellular localization. J Biol Chem. 2004 May 28; 279(22):22795-8. PMID: 15084609.
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      34. Gruber A, Chen I, Kuhen KL, Wheat JC, Law P, Wong-Staal F. Generation of dendritic cells from lentiviral vector-transduced CD34+ cells from HIV+ donors. J Med Virol. 2003 Jun; 70(2):183-6. PMID: 12696103.
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      35. Rhoades K, Wong-Staal F. Inverse Genomics as a powerful tool to identify novel targets for the treatment of neurodegenerative diseases. Mech Ageing Dev. 2003 Jan; 124(1):125-32. PMID: 12618015.
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      36. Yang JP, Reddy TR, Truong KT, Suhasini M, Wong-Staal F. Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Oncogene. 2002 Oct 17; 21(47):7187-94. PMID: 12370808.
        View in: PubMed
      37. Tang H, Peng T, Wong-Staal F. Novel technologies for studying virus-host interaction and discovering new drug targets for HCV and HIV. Curr Opin Pharmacol. 2002 Oct; 2(5):541-7. PMID: 12324256.
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      38. DeFife KM, Wong-Staal F. Integrated approaches to therapeutic target gene discovery. Curr Opin Drug Discov Devel. 2002 Sep; 5(5):683-9. PMID: 12630288.
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      39. Cheng L, Chaidhawangul S, Wong-Staal F, Gilbert J, Poeschla E, Toyoguchi M, El-Bradey M, Bergeron-Lynn G, Soules KA, Freeman WR. Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina. Curr Eye Res. 2002 Mar; 24(3):196-201. PMID: 12221527.
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      40. Reddy TR, Suhasini M, Xu W, Yeh LY, Yang JP, Wu J, Artzt K, Wong-Staal F. A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication. J Biol Chem. 2002 Feb 22; 277(8):5778-84. PMID: 11741900.
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      41. Krüger M, Beger C, Welch PJ, Barber JR, Manns MP, Wong-Staal F. Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. Mol Cell Biol. 2001 Dec; 21(24):8357-64. PMID: 11713272.
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      42. Cortés MJ, Wong-Staal F, Lama J. Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells. J Biol Chem. 2002 Jan 18; 277(3):1770-9. PMID: 11704677.
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      43. Gilbert JR, Wong-Staal F. HIV-2 and SIV vector systems. Somat Cell Mol Genet. 2001 Nov; 26(1-6):83-98. PMID: 12465463.
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      44. Gruber A, Wheat JC, Kuhen KL, Looney DJ, Wong-Staal F. Differential effects of HIV-1 protease inhibitors on dendritic cell immunophenotype and function. J Biol Chem. 2001 Dec 21; 276(51):47840-3. PMID: 11602580.
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      45. Gruber A, Looney DJ, Ibanez M, Wong-Staal F. Altered immunophenotype of dendritic cells generated from HIV infected subjects. Immunol Lett. 2001 Oct 1; 78(3):209-11. PMID: 11578697.
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      46. Krüger M, Beger C, Welch PJ, Barber JR, Wong-Staal F. C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification. Nucleic Acids Res. 2001 Oct 1; 29(19):E94. PMID: 11574696.
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      47. Yang JP, Tang H, Reddy TR, Wong-Staal F. Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses. J Biol Chem. 2001 Aug 17; 276(33):30694-700. PMID: 11402034.
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      48. Buchschacher GL, Wong-Staal F. Approaches to gene therapy for human immunodeficiency virus infection. Hum Gene Ther. 2001 Jun 10; 12(9):1013-9. PMID: 11399224.
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      49. Beger C, Pierce LN, Kruger M, Marcusson EG, Robbins JM, Welcsh P, Welch PJ, Welte K, King MC, Barber JR, Wong-Staal F. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. Proc Natl Acad Sci U S A. 2001 Jan 2; 98(1):130-5. PMID: 11136250.
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      50. Tang H, Wong-Staal F. Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirus. J Biol Chem. 2000 Oct 20; 275(42):32694-700. PMID: 10924507.
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      51. Reddy TR, Xu WD, Wong-Staal F. General effect of Sam68 on Rev/Rex regulated expression of complex retroviruses. Oncogene. 2000 Aug 17; 19(35):4071-4. PMID: 10962565.
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      52. Gruber A, Kan-Mitchell J, Kuhen KL, Mukai T, Wong-Staal F. Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro. Blood. 2000 Aug 15; 96(4):1327-33. PMID: 10942374.
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      53. Reddy TR, Tang H, Xu W, Wong-Staal F. Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNA. Oncogene. 2000 Jul 27; 19(32):3570-5. PMID: 10951562.
        View in: PubMed
      54. Kruger M, Beger C, Li QX, Welch PJ, Tritz R, Leavitt M, Barber JR, Wong-Staal F. Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8566-71. PMID: 10900014.
        View in: PubMed
      55. Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. J Biol Chem. 2000 Jul 14; 275(28):21396-401. PMID: 10748171.
        View in: PubMed
      56. Buchschacher GL, Wong-Staal F. Development of lentiviral vectors for gene therapy for human diseases. Blood. 2000 Apr 15; 95(8):2499-504. PMID: 10753827.
        View in: PubMed
      57. Reddy TR, Xu W, Mau JK, Goodwin CD, Suhasini M, Tang H, Frimpong K, Rose DW, Wong-Staal F. Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev. Nat Med. 1999 Jun; 5(6):635-42. PMID: 10371501.
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      58. Tang H, McDonald D, Middlesworth T, Hope TJ, Wong-Staal F. The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain. Mol Cell Biol. 1999 May; 19(5):3540-50. PMID: 10207077.
        View in: PubMed
      59. Li J, Tang H, Mullen TM, Westberg C, Reddy TR, Rose DW, Wong-Staal F. A role for RNA helicase A in post-transcriptional regulation of HIV type 1. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):709-14. PMID: 9892698.
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      60. Law P, Lane TA, Gervaix A, Looney D, Schwarz L, Young D, Ramos S, Wong-Staal F, Recktenwald D, Ho AD. Mobilization of peripheral blood progenitor cells for human immunodeficiency virus-infected individuals. Exp Hematol. 1999 Jan; 27(1):147-54. PMID: 9923453.
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      61. Tang H, Kuhen KL, Wong-Staal F. Lentivirus replication and regulation. Annu Rev Genet. 1999; 33:133-70. PMID: 10690406.
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      62. Krüger M, Beger C, Wong-Staal F. Use of ribozymes to inhibit gene expression. Methods Enzymol. 1999; 306:207-25. PMID: 10432456.
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      63. Wong-Staal F, Poeschla EM, Looney DJ. A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum Gene Ther. 1998 Nov 1; 9(16):2407-25. PMID: 9829540.
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      64. Radaelli A, Kraus G, Schmidt A, Badel P, McClure J, Hu SL, Morton W, De Giuli Morghen C, Wong-Staal F, Looney D. Genetic variation in a human immunodeficiency virus type 2 live-virus Macaca nemestrina vaccine model. J Virol. 1998 Oct; 72(10):7871-84. PMID: 9733824.
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      65. Poeschla E, Gilbert J, Li X, Huang S, Ho A, Wong-Staal F. Identification of a human immunodeficiency virus type 2 (HIV-2) encapsidation determinant and transduction of nondividing human cells by HIV-2-based lentivirus vectors. J Virol. 1998 Aug; 72(8):6527-36. PMID: 9658096.
        View in: PubMed
      66. Li X, Mukai T, Young D, Frankel S, Law P, Wong-Staal F. Transduction of CD34+ cells by a vesicular stomach virus protein G (VSV-G) pseudotyped HIV-1 vector. Stable gene expression in progeny cells, including dendritic cells. J Hum Virol. 1998 Jul-Aug; 1(5):346-52. PMID: 10195262.
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      67. Corbeau P, Wong-Staal F. Anti-HIV effects of HIV vectors. Virology. 1998 Apr 10; 243(2):268-74. PMID: 9568026.
        View in: PubMed
      68. Looney DJ, McClure J, Kent SJ, Radaelli A, Kraus G, Schmidt A, Steffy K, Greenberg P, Hu SL, Morton WR, Wong-Staal F. A minimally replicative HIV-2 live-virus vaccine protects M. nemestrina from disease after HIV-2(287) challenge. Virology. 1998 Mar 1; 242(1):150-60. PMID: 9501043.
        View in: PubMed
      69. Poeschla EM, Wong-Staal F, Looney DJ. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors. Nat Med. 1998 Mar; 4(3):354-7. PMID: 9500613.
        View in: PubMed
      70. Reddy TR, Li X, Jones Y, Ellisman MH, Ching GY, Liem RK, Wong-Staal F. Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):702-7. PMID: 9435256.
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      71. Corbeau P, Kraus G, Wong-Staal F. Transduction of human macrophages using a stable HIV-1/HIV-2-derived gene delivery system. Gene Ther. 1998 Jan; 5(1):99-104. PMID: 9536270.
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      72. Kraus G, Radaelli A, Talbott R, Leavitt M, Schmidt A, Badel P, Bartz C, Morton W, Wong-Staal F, Looney DJ. Characterization of a molecular clone of HIV type 2 infectious for Macaca nemestrina. AIDS Res Hum Retroviruses. 1998 Jan 1; 14(1):65-77. PMID: 9453253.
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      73. Gervaix A, Schwarz L, Law P, Ho AD, Looney D, Lane T, Wong-Staal F. Gene therapy targeting peripheral blood CD34+ hematopoietic stem cells of HIV-infected individuals. Hum Gene Ther. 1997 Dec 10; 8(18):2229-38. PMID: 9449376.
        View in: PubMed
      74. Reddy TR, Tang H, Li X, Wong-Staal F. Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4). Oncogene. 1997 Jun 12; 14(23):2785-92. PMID: 9190894.
        View in: PubMed
      75. Tang H, Gaietta GM, Fischer WH, Ellisman MH, Wong-Staal F. A cellular cofactor for the constitutive transport element of type D retrovirus. Science. 1997 May 30; 276(5317):1412-5. PMID: 9162007.
        View in: PubMed
      76. Gervaix A, West D, Leoni LM, Richman DD, Wong-Staal F, Corbeil J. A new reporter cell line to monitor HIV infection and drug susceptibility in vitro. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4653-8. PMID: 9114046.
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      77. Gervaix A, Li X, Kraus G, Wong-Staal F. Multigene antiviral vectors inhibit diverse human immunodeficiency virus type 1 clades. J Virol. 1997 Apr; 71(4):3048-53. PMID: 9060665.
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      78. Tang H, Xu Y, Wong-Staal F. Identification and purification of cellular proteins that specifically interact with the RNA constitutive transport elements from retrovirus D. Virology. 1997 Feb 17; 228(2):333-9. PMID: 9123840.
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      79. Wong-Staal F. Highlights from the University of California San Diego Center for AIDS Research. AIDS Res Hum Retroviruses. 1997 Jan 20; 13(2):117-20. PMID: 9007196.
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      80. Corbeau P, Kraus G, Wong-Staal F. Efficient gene transfer by a human immunodeficiency virus type 1 (HIV-1)-derived vector utilizing a stable HIV packaging cell line. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14070-5. PMID: 8943062.
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      81. Poeschla E, Corbeau P, Wong-Staal F. Development of HIV vectors for anti-HIV gene therapy. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11395-9. PMID: 8876146.
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      82. Xu J, Luznik L, Wong-Staal F, Gill GN. Hormone Receptor Regulation of the Human Immunodeficiency Virus Type 1 and Type 2 Long Terminal Repeats. J Biomed Sci. 1996 Sep-Oct; 3(5):323-331. PMID: 11725114.
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      83. Leavitt MC, Yu M, Wong-Staal F, Looney DJ. Ex vivo transduction and expansion of CD4+ lymphocytes from HIV + donors: prelude to a ribozyme gene therapy trial. Gene Ther. 1996 Jul; 3(7):599-606. PMID: 8818647.
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      84. Yamada O, Kraus G, Sargueil B, Yu Q, Burke JM, Wong-Staal F. Conservation of a hairpin ribozyme sequence in HIV-1 is required for efficient viral replication. Virology. 1996 Jun 15; 220(2):361-6. PMID: 8661387.
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      85. Xu Y, Reddy TR, Fischer WH, Wong-Staal F. A Novel hnRNP Specifically Interacts with HIV-1 RRE RNA. J Biomed Sci. 1996 Apr; 3(2):82-91. PMID: 11725088.
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      86. Yamada O, Kraus G, Luznik L, Yu M, Wong-Staal F. A chimeric human immunodeficiency virus type 1 (HIV-1) minimal Rev response element-ribozyme molecule exhibits dual antiviral function and inhibits cell-cell transmission of HIV-1. J Virol. 1996 Mar; 70(3):1596-601. PMID: 8627679.
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      87. Heusch M, Kraus G, Johnson P, Wong-Staal F. Intracellular immunization against SIVmac utilizing a hairpin ribozyme. Virology. 1996 Feb 1; 216(1):241-4. PMID: 8614996.
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      88. Wong-Staal F. Development of ribozyme gene therapy for HIV infection. Antibiot Chemother (1971). 1996; 48:226-32. PMID: 8726529.
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      89. Ho AD, Li X, Lane TA, Yu M, Law P, Wong-Staal F. Stem cells as vehicles for gene therapy: novel strategy for HIV infection. Stem Cells. 1995 Dec; 13 Suppl 3:100-5. PMID: 8747996.
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      90. Mamounas M, Looney DJ, Talbott R, Wong-Staal F. An infectious chimeric human immunodeficiency virus type 2 (HIV-2) expressing the HIV-1 principal neutralizing determinant. J Virol. 1995 Oct; 69(10):6424-9. PMID: 7666543.
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      91. Mamounas M, Leavitt M, Yu M, Wong-Staal F. Increased titer of recombinant AAV vectors by gene transfer with adenovirus coupled to DNA-polylysine complexes. Gene Ther. 1995 Aug; 2(6):429-32. PMID: 7584119.
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      92. Reddy TR, Kraus G, Suhasini M, Leavitt MC, Wong-Staal F. Identification and mapping of inhibitory sequences in the human immunodeficiency virus type 2 vif gene. J Virol. 1995 Aug; 69(8):5167-70. PMID: 7609089.
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      93. Luznik L, Martone ME, Kraus G, Zhang Y, Xu Y, Ellisman MH, Wong-Staal F. Localization of human immunodeficiency virus Rev in transfected and virus-infected cells. AIDS Res Hum Retroviruses. 1995 Jul; 11(7):795-804. PMID: 7546906.
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      94. Reddy TR, Kraus G, Yamada O, Looney DJ, Suhasini M, Wong-Staal F. Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants. J Virol. 1995 Jun; 69(6):3549-53. PMID: 7745702.
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      95. Reddy TR, Suhasini M, Rappaport J, Looney DJ, Kraus G, Wong-Staal F. Molecular cloning and characterization of a TAR-binding nuclear factor from T cells. AIDS Res Hum Retroviruses. 1995 Jun; 11(6):663-9. PMID: 7576925.
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      96. Yu M, Leavitt MC, Maruyama M, Yamada O, Young D, Ho AD, Wong-Staal F. Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):699-703. PMID: 7531339.
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      97. Yu M, Poeschla E, Yamada O, Degrandis P, Leavitt MC, Heusch M, Yees JK, Wong-Staal F, Hampel A. In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology. 1995 Jan 10; 206(1):381-6. PMID: 7831794.
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      98. Luznik L, Kraus G, Guatelli J, Richman D, Wong-Staal F. Tat-independent replication of human immunodeficiency viruses. J Clin Invest. 1995 Jan; 95(1):328-32. PMID: 7814633.
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      99. Poeschla EM, Wong-Staal F. Gene therapy and HIV disease. AIDS Clin Rev. 1995-1996; 1-45. PMID: 7488553.
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      100. Yamada O, Kraus G, Leavitt MC, Yu M, Wong-Staal F. Activity and cleavage site specificity of an anti-HIV-1 hairpin ribozyme in human T cells. Virology. 1994 Nov 15; 205(1):121-6. PMID: 7975207.
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      101. Leavitt MC, Yu M, Yamada O, Kraus G, Looney D, Poeschla E, Wong-Staal F. Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes. Hum Gene Ther. 1994 Sep; 5(9):1115-20. PMID: 7833371.
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      102. Poeschla E, Wong-Staal F. Molecular biology of HIV: challenges for the second decade. AIDS Res Hum Retroviruses. 1994 Feb; 10(2):111-2. PMID: 8198866.
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      103. Yu M, Poeschla E, Wong-Staal F. Progress towards gene therapy for HIV infection. Gene Ther. 1994 Jan; 1(1):13-26. PMID: 7584055.
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      104. Yamada O, Yu M, Yee JK, Kraus G, Looney D, Wong-Staal F. Intracellular immunization of human T cells with a hairpin ribozyme against human immunodeficiency virus type 1. Gene Ther. 1994 Jan; 1(1):38-45. PMID: 7584058.
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      105. Yu M, Ojwang J, Yamada O, Hampel A, Rapapport J, Looney D, Wong-Staal F. A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1993 Jul 1; 90(13):6340-4. PMID: 8327516.
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      106. Talbott R, Kraus G, Looney D, Wong-Staal F. Mapping the determinants of human immunodeficiency virus 2 for infectivity, replication efficiency, and cytopathicity. Proc Natl Acad Sci U S A. 1993 May 1; 90(9):4226-30. PMID: 8483938.
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      107. Steffy KR, Wong-Staal F. Transdominant inhibition of wild-type human immunodeficiency virus type 2 replication by an envelope deletion mutant. J Virol. 1993 Apr; 67(4):1854-9. PMID: 8445714.
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      108. Ojwang JO, Hampel A, Looney DJ, Wong-Staal F, Rappaport J. Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10802-6. PMID: 1438280.
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      109. Looney DJ, Li M, Walfield A, Hosein B, Badel P, Wang CY, Wong-Staal F. Type-specific and cross-reactive neutralizing antisera against HIV elicited by V3-peptide heptalysine octomers. AIDS Res Hum Retroviruses. 1992 Aug; 8(8):1381. PMID: 1466961.
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      110. Steffy KR, Kraus G, Looney DJ, Wong-Staal F. Role of the fusogenic peptide sequence in syncytium induction and infectivity of human immunodeficiency virus type 2. J Virol. 1992 Jul; 66(7):4532-5. PMID: 1602558.
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      111. Wong-Staal F, Haseltine WA. Regulatory genes of human immunodeficiency viruses. Mol Genet Med. 1992; 2:189-219. PMID: 1458225.
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      112. Wong-Staal F. The AIDS virus. What we know and what we can do about it. West J Med. 1991 Nov; 155(5):481-7. PMID: 1687714.
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      113. Steffy K, Wong-Staal F. Genetic regulation of human immunodeficiency virus. Microbiol Rev. 1991 Jun; 55(2):193-205. PMID: 1886517.
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      114. Vaishnav YN, Vaishnav M, Wong-Staal F. Identification and characterization of a nuclear factor that specifically binds to the Rev response element (RRE) of human immunodeficiency virus type 1 (HIV-1). New Biol. 1991 Feb; 3(2):142-50. PMID: 2065010.
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      115. Vaishnav YN, Wong-Staal F. The biochemistry of AIDS. Annu Rev Biochem. 1991; 60:577-630. PMID: 1883204.
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      116. Barone AD, Silva JJ, Ho DD, Gallo RC, Wong-Staal FF, Chang NT. Reactivity of E. coli-derived trans-activating protein of human T lymphotropic virus type III with sera from patients with acquired immune deficiency syndrome. J Immunol. 1986 Jul 15; 137(2):669-73. PMID: 3013999.
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