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William Hardison

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    BILE ACID EFFECTS ON THE LIVER AND BILIARY TREE
    NIH/NIDDK R01DK028446Apr 1, 1981 - Nov 30, 1991
    Role: Principal Investigator
    BILE ACID EFFECTS ON THE LIVER AND BILIARY TREE
    NIH/NIADDK R01AM028446Apr 1, 1981 - Nov 30, 1987
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Prevalence of hepatitis A, B, C and human immunodeficiency virus seropositivity among patients with acute icteric hepatitis at the Kenyatta National Hospital, Nairobi. East Afr Med J. 2004 Apr; 81(4):183-7. Atina JO, Ogutu EO, Hardison WG, Mumo J. PMID: 15884283.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Screening for chronic hepatitis B and C virus infections in an urban sexually transmitted disease clinic: rationale for integrating services. Sex Transm Dis. 2001 Mar; 28(3):166-70. Gunn RA, Murray PJ, Ackers ML, Hardison WG, Margolis HS. PMID: 11289199.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansPHPublic Health
    3. Myosin I is associated with zymogen granule membranes in the rat pancreatic acinar cell. Gastroenterology. 1997 Aug; 113(2):649-58. Poucell-Hatton S, Perkins PS, Deerinck TJ, Ellisman MH, Hardison WG, Pandol SJ. PMID: 9247487.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. I've been where it's gone, so I know what I got ... An American Fulbright Lecturer in Albania, 1994-1995. Ann Intern Med. 1996 Nov 15; 125(10):835-8. Hardison WG. PMID: 8928991.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Emergency portacaval shunt: a perspective on the perspective. Hepatology. 1995 Apr; 21(4):1203-6. Orloff MJ, Bell RH, Orloff MS, Greenburg AG, Hardison WG. PMID: 7705798.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    6. Prospective randomized trial of emergency portacaval shunt and emergency medical therapy in unselected cirrhotic patients with bleeding varices. Hepatology. 1994 Oct; 20(4 Pt 1):863-72. Orloff MJ, Bell RH, Orloff MS, Hardison WG, Greenburg AG. PMID: 7927227.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    7. Hepatocyte horseradish peroxidase uptake is saturable and inhibited by mannose-terminal glycoproteins. Am J Physiol. 1993 May; 264(5 Pt 1):G880-5. Yamaguchi Y, Dalle-Molle E, Hardison WG. PMID: 8498515.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Regenerative stimulus increases hepatocyte tight junctional permeability. Hepatology. 1992 Oct; 16(4):1061-8. Poucell S, Hardison WG, Miyai K. PMID: 1398486.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Breakdown of hepatic tight junctions during reoxygenation injury. Transplantation. 1992 Jun; 53(6):1211-4. Konno H, Lowe PJ, Hardison WG, Miyai K, Nakamura S, Baba S. PMID: 1604475.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Vasopressin and A23187 stimulate phosphorylation of myosin light chain-1 in isolated rat hepatocytes. Am J Physiol. 1991 Aug; 261(2 Pt 1):G312-9. Yamaguchi Y, Dalle-Molle E, Hardison WG. PMID: 1872400.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. The pattern of vasopressin-induced reduction in biliary output of cholephilic probes in the rat can be mimicked by dialysis. Hepatology. 1991 Jul; 14(1):175-9. Yamaguchi Y, Hardison WG. PMID: 2066066.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Function of rat hepatocyte tight junctions: studies with bile acid infusions. Am J Physiol. 1991 Jan; 260(1 Pt 1):G167-74. Hardison WG, Dalle-Molle E, Gosink E, Lowe PJ, Steinbach JH, Yamaguchi Y. PMID: 1702935.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Reoxygenation injury following anoxic perfusion preferentially impairs bile acid-independent bile flow. Eur Surg Res. 1991; 23(3-4):151-7. Konno H, Hardison WG, Miyai K. PMID: 1782960.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    14. Specificity of the hepatocyte Na(+)-dependent taurocholate transporter: influence of side chain length and charge. Hepatology. 1991 Jan; 13(1):68-72. Hardison WG, Heasley VL, Shellhamer DF. PMID: 1988346.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    15. Alkaline phosphatase activity in hepatic tissue and serum correlates with amount and type of bile acid load. Lab Invest. 1990 Jan; 62(1):87-95. Ogawa H, Mink J, Hardison WG, Miyai K. PMID: 2296160.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Effect of molecular charge on para- and transcellular access of horseradish peroxidase into rat bile. Hepatology. 1989 Jun; 9(6):866-71. Hardison WG, Lowe PJ, Shanahan M. PMID: 2714737.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    17. Role of bicarbonate in biliary excretion of diisothiocyanostilbene disulfonate. Am J Physiol. 1988 Dec; 255(6 Pt 1):G713-22. Anwer MS, Nolan K, Hardison WG. PMID: 2849312.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    18. Hormonal regulation of hepatocyte tight junctional permeability. Am J Physiol. 1988 Oct; 255(4 Pt 1):G454-61. Lowe PJ, Miyai K, Steinbach JH, Hardison WG. PMID: 2845804.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    19. Nature of taurodehydrocholic acid uptake in rat hepatocytes. Am J Physiol. 1988 Feb; 254(2 Pt 1):G269-74. Hardison WG, Lowe PJ, Gosink E. PMID: 3348379.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Reduced cholestatic potency of taurolithocholate during backward perfusion of the rat liver. Lab Invest. 1987 Jun; 56(6):576-82. Baumgartner U, Hardison WG, Miyai K. PMID: 3599905.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    21. Bile acid inhibition of taurocholate uptake by rat hepatocytes: role of OH groups. Am J Physiol. 1987 Mar; 252(3 Pt 1):G339-44. Bellentani S, Hardison WG, Marchegiano P, Zanasi G, Manenti F. PMID: 3826374.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Modulation of hepatic biotransformation and biliary excretion of bile acid by age and sinusoidal bile acid load. Am J Physiol. 1987 Jan; 252(1 Pt 1):G114-9. Baumgartner U, Miyai K, Hardison WG. PMID: 3812679.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    23. Greater taurodeoxycholate biotransformation during backward perfusion of rat liver. Am J Physiol. 1986 Oct; 251(4 Pt 1):G431-5. Baumgartner U, Miyai K, Hardison WG. PMID: 3766730.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    24. Technology illuminates a shadowy syndrome. Gastroenterology. 1986 Jul; 91(1):242-4. Hardison WG. PMID: 3710071.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Comparing health care options using the cost-benefit utility ratio. JAMA. 1986 Feb 14; 255(6):747. Steinbach JH, Hardison WG. PMID: 3080613.
      View in: PubMed   Mentions:    Fields:    
    26. Postobstructive subcellular organelle and biliary lipid composition in the rat. A selective increase in biliary lecithin output is not reflected by changes in organelle composition. J Hepatol. 1986; 3(3):318-27. Hardison WG, Evans WH. PMID: 3559141.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    27. Phospholipid, cholesterol, polypeptide and glycoprotein composition of hepatic endosome subfractions. Biochem J. 1985 Nov 15; 232(1):33-6. Evans WH, Hardison WG. PMID: 2867761.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    28. Mechanisms of liver adaptation to prolonged selective biliary obstruction (SBO) in the rat. J Hepatol. 1985; 1(5):525-35. Bellentani S, Hardison WG, Manenti F. PMID: 4056353.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. Effect of ursodeoxycholate and its taurine conjugate on bile acid synthesis and cholesterol absorption. Gastroenterology. 1984 Jul; 87(1):130-5. Hardison WG, Grundy SM. PMID: 6724255.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    30. Specificity of an Na+ -dependent taurocholate transport site in isolated rat hepatocytes. Am J Physiol. 1984 May; 246(5 Pt 1):G477-83. Hardison WG, Bellentani S, Heasley V, Shellhamer D. PMID: 6720949.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Effect of biliary pressure versus high bile acid flux on the permeability of hepatocellular tight junction. Lab Invest. 1984 May; 50(5):536-42. Toyota N, Miyai K, Hardison WG. PMID: 6716970.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    32. Bile-acid binding to isolated rat liver plasma membranes. Failure to find a specific binding site. Hoppe Seylers Z Physiol Chem. 1984 Mar; 365(3):357-63. Bellentani S, Hardison WG, Grisendi A, Barbieri I, Manenti F. PMID: 6724529.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    33. Uptake of iopanoic acid by isolated rat hepatocytes in primary culture. Am J Physiol. 1983 Jun; 244(6):G630-6. Barnhart JL, Witt BL, Hardison WG, Berk RN. PMID: 6859270.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. Similarities and differences between models of extrahepatic biliary obstruction and complete biliary retention without obstruction in the rat. Hepatology. 1983 May-Jun; 3(3):383-90. Hardison WG, Weiner RG, Hatoff DE, Miyai K. PMID: 6840684.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    35. Effect of bile acid conjugation pattern on bile acid metabolism in normal humans. Gastroenterology. 1983 Mar; 84(3):617-20. Hardison WG, Grundy SM. PMID: 6822329.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Relation of hepatic taurine pool size to bile-acid conjugation in man and animals. Prog Clin Biol Res. 1983; 125:407-17. Hardison WG. PMID: 6878417.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    37. Bile acid-dependent secretion of alkaline phosphatase in rat bile. Hepatology. 1982 Jul-Aug; 2(4):433-9. Hatoff DE, Hardison WG. PMID: 7095744.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. Cholestasis induced by scillaren administration, bicarbonate deprivation, or reduced hepatic blood flow. Exp Mol Pathol. 1982 Jun; 36(3):333-46. Miyai K, Hardison WG. PMID: 6282620.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    39. Nature of bile acid maximum secretory rate in the rat. Am J Physiol. 1981 Oct; 241(4):G337-43. Hardison WG, Hatoff DE, Miyai K, Weiner RG. PMID: 7315971.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    40. Design and methodological considerations in the National Cooperative Gallstone Study: a multicenter clinical trial. Control Clin Trials. 1981 Sep; 2(3):177-229. Lachin JM, Marks JW, Schoenfield LJ, Tyor MP, Bennett PH, Grundy SM, Hardison WG, Shaw LW, Thistle JL, Vlahcevic ZR. PMID: 7326939.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    41. Bile acids modify alkaline phosphatase induction and bile secretion pressure after bile duct obstruction in the rat. Gastroenterology. 1981 Apr; 80(4):666-72. Hatoff DE, Hardison WG. PMID: 7202938.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    42. Studies of the intestinal metabolism of oral gold. J Rheumatol. 1980 Sep-Oct; 7(5):633-8. Weisman MH, Hardison WG, Walz DT. PMID: 6777493.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. Taurine transport by rat hepatocytes in primary culture. Biochim Biophys Acta. 1980 May 08; 598(1):145-52. Hardison WG, Weiner R. PMID: 7417423.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    44. Enterohepatic circulation rates of cholic acid and chenodeoxycholic acid in man. Gut. 1979 Dec; 20(12):1078-82. Einarsson KA, Gundy SM, Hardison WG. PMID: 527882.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    45. Cholesterol and bile acid metabolism in moderately advanced, stable cirrhosis of the liver. Gastroenterology. 1979 Dec; 77(6):1183-92. von Bergmann K, Mok HY, Hardison WG, Grundy SM. PMID: 499706.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    46. Induced synthesis of alkaline phosphatase by bile acids in rat liver cell culture. Gastroenterology. 1979 Nov; 77(5):1062-7. Hatoff DE, Hardison WG. PMID: 488632.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    47. Cirrhosis--treating the ascites and encephalopathy. Med Times. 1979 May; 107(5):23-30. Hardison WG. PMID: 449639.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Effect of acute alterations in small bowel transit time upon the biliary excretion rate of bile acids. Gastroenterology. 1979 Mar; 76(3):568-74. Hardison WG, Tomaszewski N, Grundy SM. PMID: 428711.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    49. Importance of bicarbonate in bile salt independent fraction of bile flow. Am J Physiol. 1978 Aug; 235(2):E158-64. Hardison WG, Wood CA. PMID: 150796.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    50. Hepatic taurine concentration and dietary taurine as regulators of bile acid conjugation with taurine. Gastroenterology. 1978 Jul; 75(1):71-5. Hardison WG. PMID: 401099.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    51. Polyps of the colon: when and how should they be removed. Med Times. 1978 Jun; 106(6):44-51. Hardison WG. PMID: 661534.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Quantification of taurine synthesis in the intact rat and cat liver. . 1977 May; 155(1):55-8. Hardison WG, Wood CA, Proffitt JH. PMID: 859882.
      View in: PubMed   Mentions:
    53. Influence of hepatic taurine concentration on bile acid conjugation with taurine. Am J Physiol. 1977 Jan; 232(1):E75-9. Hardison WG, Proffitt JH. PMID: 835705.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    54. Fluorocarbon liver perfusion and fluorocarbon-glycine interaction. Fed Proc. 1975 May; 34(6):1516-7. Brown H, Hardison WG. PMID: 1126450.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    55. Use of hybrid computers to analyze behavior of detailed models of biological systems. II. System parameters used in bile salt stimulated biliary cholesterol excretion. Comput Biol Med. 1974 Jun; 4(1):3-17. Hardison WG, Apter JT. PMID: 4846475.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    56. Fluorocarbon sonicated as a substitute for erythrocytes in rat liver perfusion. Surgery. 1972 Mar; 71(3):388-94. Brown H, Hardison WG. PMID: 5010222.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    57. Micellar theory of biliary cholesterol excretion. Am J Physiol. 1972 Jan; 222(1):61-7. Hardison WG, Apter JT. PMID: 5060227.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    58. Bile salts and the liver. Prog Liver Dis. 1972; 4:83-95. Hardison WG. PMID: 4569013.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    59. Metabolism of sodium dehydrocholate by the rat liver: its effect on micelle formation in bile. J Lab Clin Med. 1971 May; 77(5):811-20. Hardison WG. PMID: 5557664.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    60. Transient macroamylasemia during an exacerbation of acute intermittent porphyria. Gastroenterology. 1971 May; 60(5):903-8. Hedger RW, Hardison WG. PMID: 5581334.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    61. The effect of neomycin on bile salt metabolism and fat digestion in man. J Lab Clin Med. 1969 Oct; 74(4):564-73. Hardison WG, Rosenberg IH. PMID: 5821514.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    62. Effect of secretin on bile osmolality. J Lab Clin Med. 1969 Jan; 73(1):34-41. Hardison WG, Norman JC. PMID: 5762162.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    63. Substitution of fluorocarbon for erythrocytes in rat liver perfusion. J Assoc Adv Med Instrum. 1969 Jan; 3(1 Pt 1):25-30. Brown H, Hardison WG. PMID: 5293909.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    64. Electrolyte composition of the secretin fraction of bile from the perfused pig liver. Am J Physiol. 1968 Apr; 214(4):758-63. Hardison WG, Norman JC. PMID: 5642937.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    65. Bile-salt deficiency in the steatorrhea following resection of the ileum and proximal colon. N Engl J Med. 1967 Aug 17; 277(7):337-42. Hardison WG, Rosenberg IH. PMID: 4378268.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    66. Experimental studies related to clinical xenogeneic liver perfusions. Transplantation. 1967 Jul; 5(4):Suppl:809-19. Norman JC, Covelli VH, Hardison WG, McDermott WV. PMID: 4860613.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    67. Abnormal bile-salt patterns and intestinal bacterial overgrowth associated with malabsorption. N Engl J Med. 1967 Jun 22; 276(25):1391-7. Rosenberg IH, Hardison WG, Bull DM. PMID: 6026403.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    68. Ex vivo pig liver perfusion for acute hepatic failure: bile salt composition of pig bile during perfusion. Medicine (Baltimore). 1967 Mar; 46(2):97-102. Hardison WG, Norman JC. PMID: 6027467.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    69. The viability and effect of flow upon function of the ex vivo perfused pig liver. J Lab Clin Med. 1967 Feb; 69(2):245-55. Hardison WG, Greene EA, Norman JC. PMID: 6016623.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    70. Metabolic responses during experimental hepatectomy as related to subsequent perfusion, preservation, or transplantation. Am J Surg. 1966 Sep; 112(3):407-11. Norman JC, Hardison WG, Covelli V, McDermott WV. PMID: 5331167.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    71. Prognosis in acute liver disease of the alcoholic patient. N Engl J Med. 1966 Jul 14; 275(2):61-6. Hardison WG, Lee FI. PMID: 5936867.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
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