Jeffry Isaacson

Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Dynamic sensory representations in adult auditory cortex
    NIH R01DC015239Jan 1, 2017 - Dec 31, 2021
    Role: Principal Investigator
    Chronic imaging of odor-evoked activity in olfactory bulb circuits of awake mice
    NIH R21DC012641Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Nebraska Research Network in Functional Genomics
    NIH P20RR016469Sep 30, 2001 - Apr 30, 2014
    Role: Co-Investigator
    Synaptic Processing in the Olfactory System
    NIH R01DC004682Dec 1, 2000 - Jul 31, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex. Elife. 2022 02 07; 11. Bitzenhofer SH, Westeinde EA, Zhang HB, Isaacson JS. PMID: 35129439; PMCID: PMC8860446.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    2. Interhemispheric Callosal Projections Sharpen Frequency Tuning and Enforce Response Fidelity in Primary Auditory Cortex. eNeuro. 2020 Jul/Aug; 7(4). Slater BJ, Isaacson JS. PMID: 32769158; PMCID: PMC7438056.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. Arousal regulates frequency tuning in primary auditory cortex. Proc Natl Acad Sci U S A. 2019 12 10; 116(50):25304-25310. Lin PA, Asinof SK, Edwards NJ, Isaacson JS. PMID: 31757852; PMCID: PMC6911239.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    4. Fear Learning Regulates Cortical Sensory Representations by Suppressing Habituation. Front Neural Circuits. 2017; 11:112. Gillet SN, Kato HK, Justen MA, Lai M, Isaacson JS. PMID: 29375323; PMCID: PMC5767681.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Network-Level Control of Frequency Tuning in Auditory Cortex. Neuron. 2017 Jul 19; 95(2):412-423.e4. Kato HK, Asinof SK, Isaacson JS. PMID: 28689982; PMCID: PMC5705232.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    6. Flexible Sensory Representations in Auditory Cortex Driven by Behavioral Relevance. Neuron. 2015 Dec 02; 88(5):1027-1039. Kato HK, Gillet SN, Isaacson JS. PMID: 26586181; PMCID: PMC4670799.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    7. Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex. Nat Neurosci. 2015 Apr; 18(4):531-5. Sturgill JF, Isaacson JS. PMID: 25751531; PMCID: PMC4452122.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    8. Broadcasting of cortical activity to the olfactory bulb. Cell Rep. 2015 Feb 24; 10(7):1032-9. Boyd AM, Kato HK, Komiyama T, Isaacson JS. PMID: 25704808; PMCID: PMC4342299.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    9. Single dendrite-targeting interneurons generate branch-specific inhibition. Front Neural Circuits. 2014; 8:139. Stokes CC, Teeter CM, Isaacson JS. PMID: 25505385; PMCID: PMC4243555.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. Parvalbumin-expressing interneurons linearly control olfactory bulb output. Neuron. 2013 Dec 04; 80(5):1218-31. Kato HK, Gillet SN, Peters AJ, Isaacson JS, Komiyama T. PMID: 24239124; PMCID: PMC3884945.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    11. Cortical feedback control of olfactory bulb circuits. Neuron. 2012 Dec 20; 76(6):1161-74. Boyd AM, Sturgill JF, Poo C, Isaacson JS. PMID: 23259951; PMCID: PMC3725136.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    12. Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience. Neuron. 2012 Dec 06; 76(5):962-75. Kato HK, Chu MW, Isaacson JS, Komiyama T. PMID: 23217744; PMCID: PMC3523713.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    13. How inhibition shapes cortical activity. Neuron. 2011 Oct 20; 72(2):231-43. Isaacson JS, Scanziani M. PMID: 22017986; PMCID: PMC3236361.
      View in: PubMed   Mentions: 766     Fields:    Translation:AnimalsCells
    14. A major role for intracortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex. Neuron. 2011 Oct 06; 72(1):41-8. Poo C, Isaacson JS. PMID: 21982367; PMCID: PMC3190137.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    15. Linking neuronal ensembles by associative synaptic plasticity. PLoS One. 2011; 6(6):e20486. Yuan Q, Isaacson JS, Scanziani M. PMID: 21738576; PMCID: PMC3126801.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Pyramidal cells in piriform cortex receive convergent input from distinct olfactory bulb glomeruli. J Neurosci. 2010 Oct 20; 30(42):14255-60. Apicella A, Yuan Q, Scanziani M, Isaacson JS. PMID: 20962246; PMCID: PMC2972672.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    17. From dendrite to soma: dynamic routing of inhibition by complementary interneuron microcircuits in olfactory cortex. Neuron. 2010 Aug 12; 67(3):452-65. Stokes CC, Isaacson JS. PMID: 20696382; PMCID: PMC2922014.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    18. Odor representations in mammalian cortical circuits. Curr Opin Neurobiol. 2010 Jun; 20(3):328-31. Isaacson JS. PMID: 20207132; PMCID: PMC2896888.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    19. Calcium-permeable AMPA receptors mediate glutamatergic signaling in neural precursor cells of the postnatal olfactory bulb. J Neurophysiol. 2010 Mar; 103(3):1431-7. Darcy DP, Isaacson JS. PMID: 20089820.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. J Neurosci. 2009 Jul 15; 29(28):9127-36. Hull C, Isaacson JS, Scanziani M. PMID: 19605650; PMCID: PMC2753516.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    21. Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillations. Neuron. 2009 Jun 25; 62(6):850-61. Poo C, Isaacson JS. PMID: 19555653; PMCID: PMC2702531.
      View in: PubMed   Mentions: 248     Fields:    Translation:AnimalsCells
    22. L-type calcium channels govern calcium signaling in migrating newborn neurons in the postnatal olfactory bulb. J Neurosci. 2009 Feb 25; 29(8):2510-8. Darcy DP, Isaacson JS. PMID: 19244525; PMCID: PMC2677619.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. An early critical period for long-term plasticity and structural modification of sensory synapses in olfactory cortex. J Neurosci. 2007 Jul 11; 27(28):7553-8. Poo C, Isaacson JS. PMID: 17626216; PMCID: PMC6672607.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    24. Strong single-fiber sensory inputs to olfactory cortex: implications for olfactory coding. Neuron. 2006 Feb 02; 49(3):357-63. Franks KM, Isaacson JS. PMID: 16446140.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    25. Synapse-specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex. Neuron. 2005 Jul 07; 47(1):101-14. Franks KM, Isaacson JS. PMID: 15996551.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    26. Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit. Nat Neurosci. 2005 Mar; 8(3):354-64. Murphy GJ, Darcy DP, Isaacson JS. PMID: 15696160.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    27. Sensory neuron signaling to the brain: properties of transmitter release from olfactory nerve terminals. J Neurosci. 2004 Mar 24; 24(12):3023-30. Murphy GJ, Glickfeld LL, Balsen Z, Isaacson JS. PMID: 15044541; PMCID: PMC6729835.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    28. In vivo whole-cell recording of odor-evoked synaptic transmission in the rat olfactory bulb. J Neurosci. 2003 May 15; 23(10):4108-16. Cang J, Isaacson JS. PMID: 12764098; PMCID: PMC6741073.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    29. GABA(B) receptors inhibit dendrodendritic transmission in the rat olfactory bulb. J Neurosci. 2003 Mar 15; 23(6):2032-9. Isaacson JS, Vitten H. PMID: 12657661; PMCID: PMC6742016.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    30. Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb. Neuron. 2003 Feb 20; 37(4):639-47. Murphy GJ, Isaacson JS. PMID: 12597861.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. Synaptic transmission: exciting times for presynaptic receptors. Curr Biol. 2001 Sep 04; 11(17):R695-7. Vitten H, Isaacson JS. PMID: 11553342.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    32. Mechanisms governing dendritic gamma-aminobutyric acid (GABA) release in the rat olfactory bulb. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):337-42. Isaacson JS. PMID: 11120892; PMCID: PMC14591.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    33. Spillover in the spotlight. Curr Biol. 2000 Jun 29; 10(13):R475-7. Isaacson JS. PMID: 10898970.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    34. Glutamate spillover mediates excitatory transmission in the rat olfactory bulb. Neuron. 1999 Jun; 23(2):377-84. Isaacson JS. PMID: 10399942.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    35. Modulation of motoneuron N-methyl-D-aspartate receptors by the inhibitory neurotransmitter glycine. J Physiol Paris. 1999 Jan-Apr; 93(1-2):23-7. Berger AJ, Isaacson JS. PMID: 10084706.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. GABAB receptor-mediated modulation of presynaptic currents and excitatory transmission at a fast central synapse. J Neurophysiol. 1998 Sep; 80(3):1571-6. Isaacson JS. PMID: 9744963.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    37. Olfactory reciprocal synapses: dendritic signaling in the CNS. Neuron. 1998 Apr; 20(4):749-61. Isaacson JS, Strowbridge BW. PMID: 9581766.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    38. NMDA and non-NMDA receptors are co-localized at excitatory synapses of rat hypoglossal motoneurons. Neurosci Lett. 1997 May 09; 227(1):5-8. O'Brien JA, Isaacson JS, Berger AJ. PMID: 9178845.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. GABA(B)-mediated presynaptic inhibition of excitatory transmission and synaptic vesicle dynamics in cultured hippocampal neurons. Neuron. 1997 Jan; 18(1):143-52. Isaacson JS, Hille B. PMID: 9010212.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    40. Amplitude and time course of spontaneous and evoked excitatory postsynaptic currents in bushy cells of the anteroventral cochlear nucleus. J Neurophysiol. 1996 Sep; 76(3):1566-71. Isaacson JS, Walmsley B. PMID: 8890276.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    41. Counting quanta: direct measurements of transmitter release at a central synapse. Neuron. 1995 Oct; 15(4):875-84. Isaacson JS, Walmsley B. PMID: 7576636.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    42. Channels underlying the slow afterhyperpolarization in hippocampal pyramidal neurons: neurotransmitters modulate the open probability. Neuron. 1995 Aug; 15(2):435-41. Sah P, Isaacson JS. PMID: 7646895.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    43. Receptors underlying excitatory synaptic transmission in slices of the rat anteroventral cochlear nucleus. J Neurophysiol. 1995 Mar; 73(3):964-73. Isaacson JS, Walmsley B. PMID: 7608781.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    44. The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus. J Neurophysiol. 1993 Nov; 70(5):2187-91. Isaacson JS, Nicoll RA. PMID: 7905032.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    45. Local and diffuse synaptic actions of GABA in the hippocampus. Neuron. 1993 Feb; 10(2):165-75. Isaacson JS, Solís JM, Nicoll RA. PMID: 7679913.
      View in: PubMed   Mentions: 215     Fields:    Translation:AnimalsCells
    46. Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10936-40. Isaacson JS, Nicoll RA. PMID: 1660156; PMCID: PMC53047.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    47. Solubilization, partial purification, and properties of omega-conotoxin receptors associated with voltage-dependent calcium channels from rat brain synaptosomes. Ann N Y Acad Sci. 1989; 560:39-52. Rosenberg RL, Isaacson JS, Tsien RW. PMID: 2545145.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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