Jeffry Isaacson

Title(s)	Emeritus Professor, Neurosciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

research activities and funding

Dynamic sensory representations in adult auditory cortex
NIH R01DC015239Jan 1, 2017 - Dec 31, 2021
Role: Principal Investigator

Chronic imaging of odor-evoked activity in olfactory bulb circuits of awake mice
NIH R21DC012641Jul 1, 2012 - Jun 30, 2015
Role: Principal Investigator

Nebraska Research Network in Functional Genomics
NIH P20RR016469Sep 30, 2001 - Apr 30, 2014
Role: Co-Investigator

Synaptic Processing in the Olfactory System
NIH R01DC004682Dec 1, 2000 - Jul 31, 2021
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex. Elife. 2022 02 07; 11. Bitzenhofer SH, Westeinde EA, Zhang HB, Isaacson JS. PMID: 35129439; PMCID: PMC8860446.

View in: PubMed Mentions: 15 Fields:
Bio Biology
Translation:Humans Cells
Interhemispheric Callosal Projections Sharpen Frequency Tuning and Enforce Response Fidelity in Primary Auditory Cortex. eNeuro. 2020 Jul/Aug; 7(4). Slater BJ, Isaacson JS. PMID: 32769158; PMCID: PMC7438056.

View in: PubMed Mentions: 6 Fields:
Bra Brain Neu Neurology
Translation:Animals Cells
Arousal regulates frequency tuning in primary auditory cortex. Proc Natl Acad Sci U S A. 2019 12 10; 116(50):25304-25310. Lin PA, Asinof SK, Edwards NJ, Isaacson JS. PMID: 31757852; PMCID: PMC6911239.

View in: PubMed Mentions: 20 Fields:
Sci Science
Translation:Animals
Fear Learning Regulates Cortical Sensory Representations by Suppressing Habituation. Front Neural Circuits. 2017; 11:112. Gillet SN, Kato HK, Justen MA, Lai M, Isaacson JS. PMID: 29375323; PMCID: PMC5767681.

View in: PubMed Mentions: 7 Fields:
Bra Brain Neu Neurology
Translation:Animals Cells
Network-Level Control of Frequency Tuning in Auditory Cortex. Neuron. 2017 Jul 19; 95(2):412-423.e4. Kato HK, Asinof SK, Isaacson JS. PMID: 28689982; PMCID: PMC5705232.

View in: PubMed Mentions: 101 Fields:
Neu Neurology
Translation:Animals Cells
Flexible Sensory Representations in Auditory Cortex Driven by Behavioral Relevance. Neuron. 2015 Dec 02; 88(5):1027-1039. Kato HK, Gillet SN, Isaacson JS. PMID: 26586181; PMCID: PMC4670799.

View in: PubMed Mentions: 121 Fields:
Neu Neurology
Translation:Animals Cells
Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex. Nat Neurosci. 2015 Apr; 18(4):531-5. Sturgill JF, Isaacson JS. PMID: 25751531; PMCID: PMC4452122.

View in: PubMed Mentions: 30 Fields:
Neu Neurology
Translation:Animals Cells
Broadcasting of cortical activity to the olfactory bulb. Cell Rep. 2015 Feb 24; 10(7):1032-9. Boyd AM, Kato HK, Komiyama T, Isaacson JS. PMID: 25704808; PMCID: PMC4342299.

View in: PubMed Mentions: 45 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals
Single dendrite-targeting interneurons generate branch-specific inhibition. Front Neural Circuits. 2014; 8:139. Stokes CC, Teeter CM, Isaacson JS. PMID: 25505385; PMCID: PMC4243555.

View in: PubMed Mentions: 8 Fields:
Bra Brain Neu Neurology
Translation:Animals Cells
Parvalbumin-expressing interneurons linearly control olfactory bulb output. Neuron. 2013 Dec 04; 80(5):1218-31. Kato HK, Gillet SN, Peters AJ, Isaacson JS, Komiyama T. PMID: 24239124; PMCID: PMC3884945.

View in: PubMed Mentions: 101 Fields:
Neu Neurology
Translation:Animals Cells
Cortical feedback control of olfactory bulb circuits. Neuron. 2012 Dec 20; 76(6):1161-74. Boyd AM, Sturgill JF, Poo C, Isaacson JS. PMID: 23259951; PMCID: PMC3725136.

View in: PubMed Mentions: 158 Fields:
Neu Neurology
Translation:Animals Cells
Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience. Neuron. 2012 Dec 06; 76(5):962-75. Kato HK, Chu MW, Isaacson JS, Komiyama T. PMID: 23217744; PMCID: PMC3523713.

View in: PubMed Mentions: 139 Fields:
Neu Neurology
Translation:Humans Animals Cells
How inhibition shapes cortical activity. Neuron. 2011 Oct 20; 72(2):231-43. Isaacson JS, Scanziani M. PMID: 22017986; PMCID: PMC3236361.

View in: PubMed Mentions: 771 Fields:
Neu Neurology
A major role for intracortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex. Neuron. 2011 Oct 06; 72(1):41-8. Poo C, Isaacson JS. PMID: 21982367; PMCID: PMC3190137.

View in: PubMed Mentions: 71 Fields:
Neu Neurology
Linking neuronal ensembles by associative synaptic plasticity. PLoS One. 2011; 6(6):e20486. Yuan Q, Isaacson JS, Scanziani M. PMID: 21738576; PMCID: PMC3126801.

View in: PubMed Mentions: 11 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Pyramidal cells in piriform cortex receive convergent input from distinct olfactory bulb glomeruli. J Neurosci. 2010 Oct 20; 30(42):14255-60. Apicella A, Yuan Q, Scanziani M, Isaacson JS. PMID: 20962246; PMCID: PMC2972672.

View in: PubMed Mentions: 35 Fields:
Neu Neurology
From dendrite to soma: dynamic routing of inhibition by complementary interneuron microcircuits in olfactory cortex. Neuron. 2010 Aug 12; 67(3):452-65. Stokes CC, Isaacson JS. PMID: 20696382; PMCID: PMC2922014.

View in: PubMed Mentions: 71 Fields:
Neu Neurology
Odor representations in mammalian cortical circuits. Curr Opin Neurobiol. 2010 Jun; 20(3):328-31. Isaacson JS. PMID: 20207132; PMCID: PMC2896888.

View in: PubMed Mentions: 40 Fields:
Bio Biology Neu Neurology
Calcium-permeable AMPA receptors mediate glutamatergic signaling in neural precursor cells of the postnatal olfactory bulb. J Neurophysiol. 2010 Mar; 103(3):1431-7. Darcy DP, Isaacson JS. PMID: 20089820.

View in: PubMed Mentions: 6 Fields:
Neu Neurology Phy Physiology
Translation:Animals Cells
Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. J Neurosci. 2009 Jul 15; 29(28):9127-36. Hull C, Isaacson JS, Scanziani M. PMID: 19605650; PMCID: PMC2753516.

View in: PubMed Mentions: 70 Fields:
Neu Neurology
Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillations. Neuron. 2009 Jun 25; 62(6):850-61. Poo C, Isaacson JS. PMID: 19555653; PMCID: PMC2702531.

View in: PubMed Mentions: 220 Fields:
Neu Neurology
L-type calcium channels govern calcium signaling in migrating newborn neurons in the postnatal olfactory bulb. J Neurosci. 2009 Feb 25; 29(8):2510-8. Darcy DP, Isaacson JS. PMID: 19244525; PMCID: PMC2677619.

View in: PubMed Mentions: 14 Fields:
Neu Neurology
An early critical period for long-term plasticity and structural modification of sensory synapses in olfactory cortex. J Neurosci. 2007 Jul 11; 27(28):7553-8. Poo C, Isaacson JS. PMID: 17626216; PMCID: PMC6672607.

View in: PubMed Mentions: 38 Fields:
Neu Neurology
Translation:Animals Cells
Strong single-fiber sensory inputs to olfactory cortex: implications for olfactory coding. Neuron. 2006 Feb 02; 49(3):357-63. Franks KM, Isaacson JS. PMID: 16446140.

View in: PubMed Mentions: 58 Fields:
Neu Neurology
Translation:Animals Cells
Synapse-specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex. Neuron. 2005 Jul 07; 47(1):101-14. Franks KM, Isaacson JS. PMID: 15996551.

View in: PubMed Mentions: 67 Fields:
Neu Neurology
Translation:Animals Cells
Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit. Nat Neurosci. 2005 Mar; 8(3):354-64. Murphy GJ, Darcy DP, Isaacson JS. PMID: 15696160.

View in: PubMed Mentions: 83 Fields:
Neu Neurology
Translation:Animals Cells
Sensory neuron signaling to the brain: properties of transmitter release from olfactory nerve terminals. J Neurosci. 2004 Mar 24; 24(12):3023-30. Murphy GJ, Glickfeld LL, Balsen Z, Isaacson JS. PMID: 15044541; PMCID: PMC6729835.

View in: PubMed Mentions: 68 Fields:
Neu Neurology
Translation:Animals Cells
In vivo whole-cell recording of odor-evoked synaptic transmission in the rat olfactory bulb. J Neurosci. 2003 May 15; 23(10):4108-16. Cang J, Isaacson JS. PMID: 12764098; PMCID: PMC6741073.

View in: PubMed Mentions: 135 Fields:
Neu Neurology
Translation:Animals Cells
GABA(B) receptors inhibit dendrodendritic transmission in the rat olfactory bulb. J Neurosci. 2003 Mar 15; 23(6):2032-9. Isaacson JS, Vitten H. PMID: 12657661; PMCID: PMC6742016.

View in: PubMed Mentions: 26 Fields:
Neu Neurology
Translation:Animals Cells
Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb. Neuron. 2003 Feb 20; 37(4):639-47. Murphy GJ, Isaacson JS. PMID: 12597861.

View in: PubMed Mentions: 17 Fields:
Neu Neurology
Translation:Animals Cells
Glutamate-mediated extrasynaptic inhibition: direct coupling of NMDA receptors to Ca(2+)-activated K+ channels. Neuron. 2001 Sep 27; 31(6):1027-34. Isaacson JS, Murphy GJ. PMID: 11580901.

View in: PubMed Mentions: 54 Fields:
Neu Neurology
Translation:Animals Cells
Synaptic transmission: exciting times for presynaptic receptors. Curr Biol. 2001 Sep 04; 11(17):R695-7. Vitten H, Isaacson JS. PMID: 11553342.

View in: PubMed Mentions: 1 Fields:
Bio Biology
Translation:Animals Cells
Mechanisms governing dendritic gamma-aminobutyric acid (GABA) release in the rat olfactory bulb. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):337-42. Isaacson JS. PMID: 11120892; PMCID: PMC14591.

View in: PubMed Mentions: 51 Fields:
Sci Science
Translation:Animals Cells
Spillover in the spotlight. Curr Biol. 2000 Jun 29; 10(13):R475-7. Isaacson JS. PMID: 10898970.

View in: PubMed Mentions: 14 Fields:
Bio Biology
Translation:Animals Cells
Glutamate spillover mediates excitatory transmission in the rat olfactory bulb. Neuron. 1999 Jun; 23(2):377-84. Isaacson JS. PMID: 10399942.

View in: PubMed Mentions: 67 Fields:
Neu Neurology
Translation:Animals Cells
Modulation of motoneuron N-methyl-D-aspartate receptors by the inhibitory neurotransmitter glycine. J Physiol Paris. 1999 Jan-Apr; 93(1-2):23-7. Berger AJ, Isaacson JS. PMID: 10084706.

View in: PubMed Mentions: 2 Fields:
Phy Physiology
Translation:Animals Cells
GABAB receptor-mediated modulation of presynaptic currents and excitatory transmission at a fast central synapse. J Neurophysiol. 1998 Sep; 80(3):1571-6. Isaacson JS. PMID: 9744963.

View in: PubMed Mentions: 29 Fields:
Neu Neurology Phy Physiology
Translation:Animals Cells
Olfactory reciprocal synapses: dendritic signaling in the CNS. Neuron. 1998 Apr; 20(4):749-61. Isaacson JS, Strowbridge BW. PMID: 9581766.

View in: PubMed Mentions: 190 Fields:
Neu Neurology
Translation:Animals Cells
NMDA and non-NMDA receptors are co-localized at excitatory synapses of rat hypoglossal motoneurons. Neurosci Lett. 1997 May 09; 227(1):5-8. O'Brien JA, Isaacson JS, Berger AJ. PMID: 9178845.

View in: PubMed Mentions: 12 Fields:
Neu Neurology
Translation:Animals Cells
GABA(B)-mediated presynaptic inhibition of excitatory transmission and synaptic vesicle dynamics in cultured hippocampal neurons. Neuron. 1997 Jan; 18(1):143-52. Isaacson JS, Hille B. PMID: 9010212.

View in: PubMed Mentions: 32 Fields:
Neu Neurology
Translation:Animals Cells
Amplitude and time course of spontaneous and evoked excitatory postsynaptic currents in bushy cells of the anteroventral cochlear nucleus. J Neurophysiol. 1996 Sep; 76(3):1566-71. Isaacson JS, Walmsley B. PMID: 8890276.

View in: PubMed Mentions: 38 Fields:
Neu Neurology Phy Physiology
Translation:Animals Cells
Counting quanta: direct measurements of transmitter release at a central synapse. Neuron. 1995 Oct; 15(4):875-84. Isaacson JS, Walmsley B. PMID: 7576636.

View in: PubMed Mentions: 79 Fields:
Neu Neurology
Translation:Animals Cells
Channels underlying the slow afterhyperpolarization in hippocampal pyramidal neurons: neurotransmitters modulate the open probability. Neuron. 1995 Aug; 15(2):435-41. Sah P, Isaacson JS. PMID: 7646895.

View in: PubMed Mentions: 26 Fields:
Neu Neurology
Translation:Cells
Receptors underlying excitatory synaptic transmission in slices of the rat anteroventral cochlear nucleus. J Neurophysiol. 1995 Mar; 73(3):964-73. Isaacson JS, Walmsley B. PMID: 7608781.

View in: PubMed Mentions: 26 Fields:
Neu Neurology Phy Physiology
Translation:Animals Cells
The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus. J Neurophysiol. 1993 Nov; 70(5):2187-91. Isaacson JS, Nicoll RA. PMID: 7905032.

View in: PubMed Mentions: 28 Fields:
Neu Neurology Phy Physiology
Translation:Animals Cells
Local and diffuse synaptic actions of GABA in the hippocampus. Neuron. 1993 Feb; 10(2):165-75. Isaacson JS, Solís JM, Nicoll RA. PMID: 7679913.

View in: PubMed Mentions: 181 Fields:
Neu Neurology
Translation:Animals Cells
Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10936-40. Isaacson JS, Nicoll RA. PMID: 1660156; PMCID: PMC53047.

View in: PubMed Mentions: 35 Fields:
Sci Science
Translation:Animals Cells
Solubilization, partial purification, and properties of omega-conotoxin receptors associated with voltage-dependent calcium channels from rat brain synaptosomes. Ann N Y Acad Sci. 1989; 560:39-52. Rosenberg RL, Isaacson JS, Tsien RW. PMID: 2545145.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Animals Cells