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    Neil Richtand

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #0603
    CA La Jolla 92093
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      Biography

      Neil M. Richtand, M.D., Ph.D. is Professor of Psychiatry at the University of California, San Diego School of Medicine, and Chief of the Psychiatry Service at the VA San Diego Healthcare System. Dr. Richtand graduated with a B.A. in Biology from Carleton College, and received his M.D. and Ph.D. degrees from Vanderbilt University School of Medicine. He completed residency training in psychiatry and a fellowship in molecular neurobiology at the University of California, San Diego. Dr. Richtand was a faculty member in the Departments of Psychiatry and Neuroscience, and attending psychiatrist at the Cincinnati VA Medical Center from 1994 through 2013. He directs a preclinical research program studying animal models of relevance to psychiatric disorders including schizophrenia, drug dependence, and traumatic brain injury. He has also been involved in clinical research in antipsychotic medications and mood stabilizers.


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      Conditioned place preference to amphetamine following prenatal immune activation
      NIH/NIDA R21DA031876Jul 15, 2012 - Mar 31, 2015
      Role: Principal Investigator
      Antipsychotics, hypoglycemia, glutamate and cognition
      NIH/NIMH R21MH083192Aug 20, 2008 - Jul 31, 2011
      Role: Principal Investigator
      Role of D3 dopamine receptor in behavioral sensitization
      NIH/NIDA R01DA016778Apr 1, 2004 - Mar 31, 2009
      Role: Principal Investigator

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Moore RC, Marquine MJ, Straus E, Depp CA, Moore DJ, Schiehser DM, Richtand N, Jeste DV, Eyler LT. Predictors and Barriers to Mental Health Treatment Utilization Among Older Veterans Living With HIV. Prim Care Companion CNS Disord. 2017 Feb 02; 19(1). PMID: 28157277.
        View in: PubMed
      2. Brandel MG, Hirshman BR, McCutcheon BA, Tringale K, Carroll K, Richtand N, Perry W, Chen CC, Carter BS. The Association between Psychiatric Comorbidities and Outcomes for Inpatients with Traumatic Brain Injury. J Neurotrauma. 2017 Mar 01; 34(5):1005-1016. PMID: 27573722.
        View in: PubMed
      3. Cassella SN, Hemmerle AM, Lundgren KH, Kyser TL, Ahlbrand R, Bronson SL, Richtand N, Seroogy KB. Maternal immune activation alters glutamic acid decarboxylase-67 expression in the brains of adult rat offspring. Schizophr Res. 2016 Mar; 171(1-3):195-9. PMID: 26830319; PMCID: PMC4803111 [Available on 03/01/17].
      4. Hemmerle AM, Ahlbrand R, Bronson SL, Lundgren KH, Richtand N, Seroogy KB. Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation. Schizophr Res. 2015 Oct; 168(1-2):411-20. PMID: 26206493; PMCID: PMC4591187 [Available on 10/01/16].
      5. Vorhees CV, Graham DL, Braun AA, Schaefer TL, Skelton MR, Richtand N, Williams MT. Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine. Neurotoxicol Teratol. 2015 Jan-Feb; 47:54-65. PMID: 25450663; PMCID: PMC4291316.
      6. Isom AM, Gudelsky GA, Benoit SC, Richtand N. Antipsychotic medications, glutamate, and cell death: a hidden, but common medication side effect? Med Hypotheses. 2013 Mar; 80(3):252-8. PMID: 23265349.
        View in: PubMed
      7. Richtand N, Ahlbrand R, Horn PS, Chambers B, Davis J, Benoit S. Effects of prenatal immune activation and peri-adolescent stress on amphetamine-induced conditioned place preference in the rat. Psychopharmacology (Berl). 2012 Jul; 222(2):313-24. PMID: 22290326; PMCID: PMC3410038.
      8. Vorhees CV, Graham DL, Braun AA, Schaefer TL, Skelton MR, Richtand N, Williams MT. Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC. Synapse. 2012 Aug; 66(8):725-37. PMID: 22473973; PMCID: PMC3370146.
      9. Roenker NL, Gudelsky GA, Ahlbrand R, Horn PS, Richtand N. Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex. Neuropharmacology. 2012 Sep; 63(4):575-81. PMID: 22579658; PMCID: PMC3392446.
      10. Richtand N, Ahlbrand R, Horn P, Tambyraja R, Grainger M, Bronson SL, McNamara RK. Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response. Physiol Behav. 2012 May 15; 106(2):171-7. PMID: 22342193; PMCID: PMC3326654.
      11. Roenker NL, Gudelsky G, Ahlbrand R, Bronson SL, Kern JR, Waterman H, Richtand N. Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801. Neurosci Lett. 2011 Aug 18; 500(3):167-71. PMID: 21699956; PMCID: PMC3144266.
      12. Richtand N, Ahlbrand R, Horn P, Stanford K, Bronson SL, McNamara RK. Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation. J Psychiatr Res. 2011 Sep; 45(9):1194-201. PMID: 21440257; PMCID: PMC3156843.
      13. Bronson SL, Ahlbrand R, Horn PS, Kern JR, Richtand N. Individual differences in maternal response to immune challenge predict offspring behavior: contribution of environmental factors. Behav Brain Res. 2011 Jun 20; 220(1):55-64. PMID: 21255612; PMCID: PMC3064713.
      14. Richtand N, Liu Y, Ahlbrand R, Sullivan JR, Newman AH, McNamara RK. Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression. Synapse. 2010 Aug; 64(8):634-43. PMID: 20340170; PMCID: PMC2888922.
      15. Pitchers KK, Balfour ME, Lehman MN, Richtand N, Yu L, Coolen LM. Neuroplasticity in the mesolimbic system induced by natural reward and subsequent reward abstinence. Biol Psychiatry. 2010 May 01; 67(9):872-9. PMID: 20015481; PMCID: PMC2854191.
      16. Ostrander MM, Ulrich-Lai YM, Choi DC, Flak JN, Richtand N, Herman JP. Chronic stress produces enduring decreases in novel stress-evoked c-fos mRNA expression in discrete brain regions of the rat. Stress. 2009 Nov; 12(6):469-77. PMID: 20102318; PMCID: PMC3676895.
      17. McNamara RK, Sullivan J, Richtand N, Jandacek R, Rider T, Tso P, Campbell N, Lipton J. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations. Synapse. 2008 Oct; 62(10):725-35. PMID: 18651642.
        View in: PubMed
      18. McNamara RK, Jandacek R, Rider T, Tso P, Stanford KE, Hahn CG, Richtand N. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res. 2008 Sep 30; 160(3):285-99. PMID: 18715653; PMCID: PMC2620106.
      19. Richtand N, Welge JA, Logue AD, Keck PE, Strakowski SM, McNamara RK. Role of serotonin and dopamine receptor binding in antipsychotic efficacy. Prog Brain Res. 2008; 172:155-75. PMID: 18772032.
        View in: PubMed
      20. Richtand N, McNamara RK. Serotonin and dopamine interactions in psychosis prevention. Prog Brain Res. 2008; 172:141-53. PMID: 18772031.
        View in: PubMed
      21. Yates JW, Meij JT, Sullivan JR, Richtand N, Yu L. Bimodal effect of amphetamine on motor behaviors in C57BL/6 mice. Neurosci Lett. 2007 Oct 29; 427(1):66-70. PMID: 17920769; PMCID: PMC2117340.
      22. McNamara RK, Sullivan J, Richtand N. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment. J Psychiatr Res. 2008 May; 42(6):458-68. PMID: 17628596.
        View in: PubMed
      23. Pritchard LM, Newman AH, McNamara RK, Logue AD, Taylor B, Welge JA, Xu M, Zhang J, Richtand N. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol Biochem Behav. 2007 Apr; 86(4):718-26. PMID: 17408730.
        View in: PubMed
      24. Richtand N, Welge JA, Logue AD, Keck PE, Strakowski SM, McNamara RK. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug; 32(8):1715-26. PMID: 17251913.
        View in: PubMed
      25. McNamara RK, Jandacek R, Rider T, Tso P, Hahn CG, Richtand N, Stanford KE. Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. Schizophr Res. 2007 Mar; 91(1-3):37-50. PMID: 17236749; PMCID: PMC1853256.
      26. McNamara RK, Hahn CG, Jandacek R, Rider T, Tso P, Stanford KE, Richtand N. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry. 2007 Jul 01; 62(1):17-24. PMID: 17188654.
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      27. McNamara RK, Logue A, Stanford K, Xu M, Zhang J, Richtand N. Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine. Synapse. 2006 Oct; 60(5):399-405. PMID: 16856172; PMCID: PMC1815379.
      28. McNamara RK, Levant B, Taylor B, Ahlbrand R, Liu Y, Sullivan JR, Stanford K, Richtand N. C57BL/6J mice exhibit reduced dopamine D3 receptor-mediated locomotor-inhibitory function relative to DBA/2J mice. Neuroscience. 2006 Nov 17; 143(1):141-53. PMID: 16938406; PMCID: PMC1815378.
      29. McNamara RK, Ostrander M, Abplanalp W, Richtand N, Benoit SC, Clegg DJ. Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov; 75(4-5):237-57. PMID: 16935483.
        View in: PubMed
      30. Richtand N. Behavioral sensitization, alternative splicing, and d3 dopamine receptor-mediated inhibitory function. Neuropsychopharmacology. 2006 Nov; 31(11):2368-75. PMID: 16855531; PMCID: PMC1815380.
      31. Pritchard LM, Logue AD, Taylor BC, Ahlbrand R, Welge JA, Tang Y, Sharp FR, Richtand N. Relative expression of D3 dopamine receptor and alternative splice variant D3nf mRNA in high and low responders to novelty. Brain Res Bull. 2006 Oct 16; 70(4-6):296-303. PMID: 17027765; PMCID: PMC1815377.
      32. Ostrander MM, Ulrich-Lai YM, Choi DC, Richtand N, Herman JP. Hypoactivity of the hypothalamo-pituitary-adrenocortical axis during recovery from chronic variable stress. Endocrinology. 2006 Apr; 147(4):2008-17. PMID: 16396985; PMCID: PMC1815381.
      33. Richtand N, Taylor B, Welge JA, Ahlbrand R, Ostrander MM, Burr J, Hayes S, Coolen LM, Pritchard LM, Logue A, Herman JP, McNamara RK. Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions. Neuropsychopharmacology. 2006 Jan; 31(1):77-89. PMID: 15957008; PMCID: PMC1847785.
      34. Grimm SW, Richtand N, Winter HR, Stams KR, Reele SB. Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. Br J Clin Pharmacol. 2006 Jan; 61(1):58-69. PMID: 16390352; PMCID: PMC1884989.
      35. Sah R, Pritchard LM, Richtand N, Ahlbrand R, Eaton K, Sallee FR, Herman JP. Expression of the glucocorticoid-induced receptor mRNA in rat brain. Neuroscience. 2005; 133(1):281-92. PMID: 15893650; PMCID: PMC1815382.
      36. Ostrander MM, Richtand N, Herman JP. Stress and amphetamine induce Fos expression in medial prefrontal cortex neurons containing glucocorticoid receptors. Brain Res. 2003 Nov 14; 990(1-2):209-14. PMID: 14568346.
        View in: PubMed
      37. Richtand N, Welge JA, Levant B, Logue AD, Hayes S, Pritchard LM, Geracioti TD, Coolen LM, Berger SP. Altered behavioral response to dopamine D3 receptor agonists 7-OH-DPAT and PD 128907 following repetitive amphetamine administration. Neuropsychopharmacology. 2003 Aug; 28(8):1422-32. PMID: 12700693.
        View in: PubMed
      38. Pritchard LM, Logue AD, Hayes S, Welge JA, Xu M, Zhang J, Berger SP, Richtand N. 7-OH-DPAT and PD 128907 selectively activate the D3 dopamine receptor in a novel environment. Neuropsychopharmacology. 2003 Jan; 28(1):100-7. PMID: 12496945.
        View in: PubMed
      39. Richtand N. Analysis of gene expression in striatal tissue by multiprobe RNase protection assay. Methods Mol Med. 2003; 79:181-92. PMID: 12506697.
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      40. Richtand N. Laboratory analysis of behavioral effects of drugs of abuse in rodents. Methods Mol Med. 2003; 79:475-80. PMID: 12506718.
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      41. Welge JA, Richtand N. Regression modeling of rodent locomotion data. Behav Brain Res. 2002 Jan 07; 128(1):61-9. PMID: 11755690.
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      42. Keck PE, McElroy SL, Richtand N, Tohen M. What makes a drug a primary mood stabilizer? Mol Psychiatry. 2002; 7 Suppl 1:S8-14. PMID: 11986990.
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      43. Wang D, Herman JP, Pritchard LM, Spitzer RH, Ahlbrand RL, Kramer GL, Petty F, Sallee FR, Richtand N. Cloning, expression, and regulation of a glucocorticoid-induced receptor in rat brain: effect of repetitive amphetamine. J Neurosci. 2001 Nov 15; 21(22):9027-35. PMID: 11698613.
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      44. Richtand N, Woods SC, Berger SP, Strakowski SM. D3 dopamine receptor, behavioral sensitization, and psychosis. Neurosci Biobehav Rev. 2001 Jul; 25(5):427-43. PMID: 11566480.
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      45. Richtand N, Goldsmith RJ, Nolan JE, Berger SP. The D3 dopamine receptor and substance dependence. J Addict Dis. 2001; 20(3):19-32. PMID: 11681590.
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      46. Richtand N, Logue AD, Welge JA, Perdiue J, Tubbs LJ, Spitzer RH, Sethuraman G, Geracioti TD. The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine. Brain Res. 2000 Jun 09; 867(1-2):239-42. PMID: 10837819.
        View in: PubMed
      47. Koster NL, Norman AB, Richtand N, Nickell WT, Puche AC, Pixley SK, Shipley MT. Olfactory receptor neurons express D2 dopamine receptors. J Comp Neurol. 1999 Sep 06; 411(4):666-73. PMID: 10421875.
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      48. Hondo H, Spitzer RH, Grinius B, Richtand N. Quantification of dopamine D3 receptor mRNA level associated with the development of amphetamine-induced behavioral sensitization in the rat brain. Neurosci Lett. 1999 Apr 02; 264(1-3):69-72. PMID: 10320016.
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      49. Geracioti TD, Parker S, Lowther NB, Wortman M, Richtand N. A case of treatment-refractory psychosis responsive to sertindole. Schizophr Res. 1998 Feb 27; 30(1):105-8. PMID: 9542794.
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      50. Geracioti TD, Goldsmith RJ, Friedman LM, Norman AB, Somoza E, Kasckow JW, Baker DG, Richtand N, Anthenelli RM, Keck PE. Cerebrospinal fluid neuroendocrinology of alcohol misusers. Addict Biol. 1997 Oct; 2(4):401-10. PMID: 26735945.
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      51. Richtand N, Kelsoe JR, Kuczenski R, Segal DS. Quantification of dopamine D1 and D2 receptor mRNA levels associated with the development of behavioral sensitization in amphetamine treated rats. Neurochem Int. 1997 Jul; 31(1):131-7. PMID: 9185173.
        View in: PubMed
      52. Geracioti TD, Loosen PT, Ekhator NN, Schmidt D, Chambliss B, Baker DG, Kasckow JW, Richtand N, Keck PE, Ebert MH. Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. Depress Anxiety. 1997; 6(3):89-94. PMID: 9442982.
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      53. Richtand N, Kelsoe JR, Segal DS, Kuczenski R. Regional quantification of dopamine transporter mRNA in rat brain using a ribonuclease protection assay. Neurosci Lett. 1995 Nov 17; 200(2):73-6. PMID: 8614566.
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      54. Richtand N, Kelsoe JR, Segal DS, Kuczenski R. Regional quantification of D1, D2, and D3 dopamine receptor mRNA in rat brain using a ribonuclease protection assay. Brain Res Mol Brain Res. 1995 Oct; 33(1):97-103. PMID: 8774950.
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      55. Turner BH, Wilson JS, McKenzie JC, Richtand N. MPTP produces a pattern of nigrostriatal degeneration which coincides with the mosaic organization of the caudate nucleus. Brain Res. 1988 Nov 08; 473(1):60-4. PMID: 2905203.
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      56. Atkinson J, Richtand N, Schworer C, Kuczenski R, Soderling T. Phosphorylation of purified rat striatal tyrosine hydroxylase by Ca2+/calmodulin-dependent protein kinase II: effect of an activator protein. J Neurochem. 1987 Oct; 49(4):1241-9. PMID: 2887635.
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      57. Richtand N, Inagami T, Misono K, Kuczenski R. Purification and characterization of rat striatal tyrosine hydroxylase. Comparison of the activation by cyclic AMP-dependent phosphorylation and by other effectors. J Biol Chem. 1985 Jul 15; 260(14):8465-73. PMID: 2861203.
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      58. Holick MF, Richtand N, McNeill SC, Holick SA, Frommer JE, Henley JW, Potts JT. Isolation and identification of previtamin D3 from the skin of rats exposed to ultraviolet irradiation. Biochemistry. 1979 Mar 20; 18(6):1003-8. PMID: 218609.
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      59. Holick MF, Frommer JE, McNeill SC, Richtand N, Henley JW, Potts JT. Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin. Biochem Biophys Res Commun. 1977 May 09; 76(1):107-14. PMID: 194588.
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