Loading...

Neil Richtand

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Address9500 Gilman Drive #0603
La Jolla CA 92093
vCardDownload vCard

    Collapse Overview 
    Collapse Overview

    Biography

    Neil M. Richtand, M.D., Ph.D. is Professor of Psychiatry at the University of California, San Diego School of Medicine, and Chief of the Psychiatry Service at the VA San Diego Healthcare System. Dr. Richtand graduated with a B.A. in Biology from Carleton College, and received his M.D. and Ph.D. degrees from Vanderbilt University School of Medicine. He completed residency training in psychiatry and a fellowship in molecular neurobiology at the University of California, San Diego. Dr. Richtand was a faculty member in the Departments of Psychiatry and Neuroscience, and attending psychiatrist at the Cincinnati VA Medical Center from 1994 through 2013. He directs a preclinical research program studying animal models of relevance to psychiatric disorders including schizophrenia, drug dependence, and traumatic brain injury. He has also been involved in clinical research in antipsychotic medications and mood stabilizers.


    Collapse Research 
    Collapse Research Activities and Funding
    Conditioned place preference to amphetamine following prenatal immune activation
    NIH/NIDA R21DA031876Jul 15, 2012 - Mar 31, 2015
    Role: Principal Investigator
    Antipsychotics, hypoglycemia, glutamate and cognition
    NIH/NIMH R21MH083192Aug 20, 2008 - Jul 31, 2011
    Role: Principal Investigator
    Role of D3 dopamine receptor in behavioral sensitization
    NIH/NIDA R01DA016778Apr 1, 2004 - Mar 31, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Moore RC, Marquine MJ, Straus E, Depp CA, Moore DJ, Schiehser DM, Richtand NM, Jeste DV, Eyler LT. Predictors and Barriers to Mental Health Treatment Utilization Among Older Veterans Living With HIV. Prim Care Companion CNS Disord. 2017 Feb 02; 19(1). PMID: 28157277.
      View in: PubMed
    2. Brandel MG, Hirshman BR, McCutcheon BA, Tringale K, Carroll K, Richtand NM, Perry W, Chen CC, Carter BS. The Association between Psychiatric Comorbidities and Outcomes for Inpatients with Traumatic Brain Injury. J Neurotrauma. 2017 Mar 01; 34(5):1005-1016. PMID: 27573722.
      View in: PubMed
    3. Cassella SN, Hemmerle AM, Lundgren KH, Kyser TL, Ahlbrand R, Bronson SL, Richtand NM, Seroogy KB. Maternal immune activation alters glutamic acid decarboxylase-67 expression in the brains of adult rat offspring. Schizophr Res. 2016 Mar; 171(1-3):195-9. PMID: 26830319; PMCID: PMC4803111 [Available on 03/01/17].
    4. Hemmerle AM, Ahlbrand R, Bronson SL, Lundgren KH, Richtand NM, Seroogy KB. Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation. Schizophr Res. 2015 Oct; 168(1-2):411-20. PMID: 26206493; PMCID: PMC4591187 [Available on 10/01/16].
    5. Vorhees CV, Graham DL, Braun AA, Schaefer TL, Skelton MR, Richtand NM, Williams MT. Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine. Neurotoxicol Teratol. 2015 Jan-Feb; 47:54-65. PMID: 25450663; PMCID: PMC4291316.
    6. Isom AM, Gudelsky GA, Benoit SC, Richtand NM. Antipsychotic medications, glutamate, and cell death: a hidden, but common medication side effect? Med Hypotheses. 2013 Mar; 80(3):252-8. PMID: 23265349.
      View in: PubMed
    7. Richtand NM, Ahlbrand R, Horn PS, Chambers B, Davis J, Benoit S. Effects of prenatal immune activation and peri-adolescent stress on amphetamine-induced conditioned place preference in the rat. Psychopharmacology (Berl). 2012 Jul; 222(2):313-24. PMID: 22290326; PMCID: PMC3410038.
    8. Vorhees CV, Graham DL, Braun AA, Schaefer TL, Skelton MR, Richtand NM, Williams MT. Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC. Synapse. 2012 Aug; 66(8):725-37. PMID: 22473973; PMCID: PMC3370146.
    9. Roenker NL, Gudelsky GA, Ahlbrand R, Horn PS, Richtand NM. Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex. Neuropharmacology. 2012 Sep; 63(4):575-81. PMID: 22579658; PMCID: PMC3392446.
    10. Richtand NM, Ahlbrand R, Horn P, Tambyraja R, Grainger M, Bronson SL, McNamara RK. Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response. Physiol Behav. 2012 May 15; 106(2):171-7. PMID: 22342193; PMCID: PMC3326654.
    11. Roenker NL, Gudelsky G, Ahlbrand R, Bronson SL, Kern JR, Waterman H, Richtand NM. Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801. Neurosci Lett. 2011 Aug 18; 500(3):167-71. PMID: 21699956; PMCID: PMC3144266.
    12. Richtand NM, Ahlbrand R, Horn P, Stanford K, Bronson SL, McNamara RK. Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation. J Psychiatr Res. 2011 Sep; 45(9):1194-201. PMID: 21440257; PMCID: PMC3156843.
    13. Bronson SL, Ahlbrand R, Horn PS, Kern JR, Richtand NM. Individual differences in maternal response to immune challenge predict offspring behavior: contribution of environmental factors. Behav Brain Res. 2011 Jun 20; 220(1):55-64. PMID: 21255612; PMCID: PMC3064713.
    14. Richtand NM, Liu Y, Ahlbrand R, Sullivan JR, Newman AH, McNamara RK. Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression. Synapse. 2010 Aug; 64(8):634-43. PMID: 20340170; PMCID: PMC2888922.
    15. Pitchers KK, Balfour ME, Lehman MN, Richtand NM, Yu L, Coolen LM. Neuroplasticity in the mesolimbic system induced by natural reward and subsequent reward abstinence. Biol Psychiatry. 2010 May 01; 67(9):872-9. PMID: 20015481; PMCID: PMC2854191.
    16. Ostrander MM, Ulrich-Lai YM, Choi DC, Flak JN, Richtand NM, Herman JP. Chronic stress produces enduring decreases in novel stress-evoked c-fos mRNA expression in discrete brain regions of the rat. Stress. 2009 Nov; 12(6):469-77. PMID: 20102318; PMCID: PMC3676895.
    17. McNamara RK, Sullivan J, Richtand NM, Jandacek R, Rider T, Tso P, Campbell N, Lipton J. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations. Synapse. 2008 Oct; 62(10):725-35. PMID: 18651642.
      View in: PubMed
    18. McNamara RK, Jandacek R, Rider T, Tso P, Stanford KE, Hahn CG, Richtand NM. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res. 2008 Sep 30; 160(3):285-99. PMID: 18715653; PMCID: PMC2620106.
    19. Richtand NM, McNamara RK. Serotonin and dopamine interactions in psychosis prevention. Prog Brain Res. 2008; 172:141-53. PMID: 18772031.
      View in: PubMed
    20. Richtand NM, Welge JA, Logue AD, Keck PE, Strakowski SM, McNamara RK. Role of serotonin and dopamine receptor binding in antipsychotic efficacy. Prog Brain Res. 2008; 172:155-75. PMID: 18772032.
      View in: PubMed
    21. Yates JW, Meij JT, Sullivan JR, Richtand NM, Yu L. Bimodal effect of amphetamine on motor behaviors in C57BL/6 mice. Neurosci Lett. 2007 Oct 29; 427(1):66-70. PMID: 17920769; PMCID: PMC2117340.
    22. McNamara RK, Sullivan J, Richtand NM. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment. J Psychiatr Res. 2008 May; 42(6):458-68. PMID: 17628596.
      View in: PubMed
    23. Pritchard LM, Newman AH, McNamara RK, Logue AD, Taylor B, Welge JA, Xu M, Zhang J, Richtand NM. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol Biochem Behav. 2007 Apr; 86(4):718-26. PMID: 17408730.
      View in: PubMed
    24. Richtand NM, Welge JA, Logue AD, Keck PE, Strakowski SM, McNamara RK. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug; 32(8):1715-26. PMID: 17251913.
      View in: PubMed
    25. McNamara RK, Jandacek R, Rider T, Tso P, Hahn CG, Richtand NM, Stanford KE. Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. Schizophr Res. 2007 Mar; 91(1-3):37-50. PMID: 17236749; PMCID: PMC1853256.
    26. McNamara RK, Hahn CG, Jandacek R, Rider T, Tso P, Stanford KE, Richtand NM. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry. 2007 Jul 01; 62(1):17-24. PMID: 17188654.
      View in: PubMed
    27. McNamara RK, Logue A, Stanford K, Xu M, Zhang J, Richtand NM. Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine. Synapse. 2006 Oct; 60(5):399-405. PMID: 16856172; PMCID: PMC1815379.
    28. McNamara RK, Levant B, Taylor B, Ahlbrand R, Liu Y, Sullivan JR, Stanford K, Richtand NM. C57BL/6J mice exhibit reduced dopamine D3 receptor-mediated locomotor-inhibitory function relative to DBA/2J mice. Neuroscience. 2006 Nov 17; 143(1):141-53. PMID: 16938406; PMCID: PMC1815378.
    29. McNamara RK, Ostrander M, Abplanalp W, Richtand NM, Benoit SC, Clegg DJ. Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov; 75(4-5):237-57. PMID: 16935483.
      View in: PubMed
    30. Richtand NM. Behavioral sensitization, alternative splicing, and d3 dopamine receptor-mediated inhibitory function. Neuropsychopharmacology. 2006 Nov; 31(11):2368-75. PMID: 16855531; PMCID: PMC1815380.
    31. Pritchard LM, Logue AD, Taylor BC, Ahlbrand R, Welge JA, Tang Y, Sharp FR, Richtand NM. Relative expression of D3 dopamine receptor and alternative splice variant D3nf mRNA in high and low responders to novelty. Brain Res Bull. 2006 Oct 16; 70(4-6):296-303. PMID: 17027765; PMCID: PMC1815377.
    32. Ostrander MM, Ulrich-Lai YM, Choi DC, Richtand NM, Herman JP. Hypoactivity of the hypothalamo-pituitary-adrenocortical axis during recovery from chronic variable stress. Endocrinology. 2006 Apr; 147(4):2008-17. PMID: 16396985; PMCID: PMC1815381.
    33. Richtand NM, Taylor B, Welge JA, Ahlbrand R, Ostrander MM, Burr J, Hayes S, Coolen LM, Pritchard LM, Logue A, Herman JP, McNamara RK. Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions. Neuropsychopharmacology. 2006 Jan; 31(1):77-89. PMID: 15957008; PMCID: PMC1847785.
    34. Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB. Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. Br J Clin Pharmacol. 2006 Jan; 61(1):58-69. PMID: 16390352; PMCID: PMC1884989.
    35. Sah R, Pritchard LM, Richtand NM, Ahlbrand R, Eaton K, Sallee FR, Herman JP. Expression of the glucocorticoid-induced receptor mRNA in rat brain. Neuroscience. 2005; 133(1):281-92. PMID: 15893650; PMCID: PMC1815382.
    36. Ostrander MM, Richtand NM, Herman JP. Stress and amphetamine induce Fos expression in medial prefrontal cortex neurons containing glucocorticoid receptors. Brain Res. 2003 Nov 14; 990(1-2):209-14. PMID: 14568346.
      View in: PubMed
    37. Richtand NM, Welge JA, Levant B, Logue AD, Hayes S, Pritchard LM, Geracioti TD, Coolen LM, Berger SP. Altered behavioral response to dopamine D3 receptor agonists 7-OH-DPAT and PD 128907 following repetitive amphetamine administration. Neuropsychopharmacology. 2003 Aug; 28(8):1422-32. PMID: 12700693.
      View in: PubMed
    38. Richtand NM. Analysis of gene expression in striatal tissue by multiprobe RNase protection assay. Methods Mol Med. 2003; 79:181-92. PMID: 12506697.
      View in: PubMed
    39. Richtand NM. Laboratory analysis of behavioral effects of drugs of abuse in rodents. Methods Mol Med. 2003; 79:475-80. PMID: 12506718.
      View in: PubMed
    40. Pritchard LM, Logue AD, Hayes S, Welge JA, Xu M, Zhang J, Berger SP, Richtand NM. 7-OH-DPAT and PD 128907 selectively activate the D3 dopamine receptor in a novel environment. Neuropsychopharmacology. 2003 Jan; 28(1):100-7. PMID: 12496945.
      View in: PubMed
    41. Welge JA, Richtand NM. Regression modeling of rodent locomotion data. Behav Brain Res. 2002 Jan 07; 128(1):61-9. PMID: 11755690.
      View in: PubMed
    42. Wang D, Herman JP, Pritchard LM, Spitzer RH, Ahlbrand RL, Kramer GL, Petty F, Sallee FR, Richtand NM. Cloning, expression, and regulation of a glucocorticoid-induced receptor in rat brain: effect of repetitive amphetamine. J Neurosci. 2001 Nov 15; 21(22):9027-35. PMID: 11698613.
      View in: PubMed
    43. Richtand NM, Woods SC, Berger SP, Strakowski SM. D3 dopamine receptor, behavioral sensitization, and psychosis. Neurosci Biobehav Rev. 2001 Jul; 25(5):427-43. PMID: 11566480.
      View in: PubMed
    44. Richtand NM, Goldsmith RJ, Nolan JE, Berger SP. The D3 dopamine receptor and substance dependence. J Addict Dis. 2001; 20(3):19-32. PMID: 11681590.
      View in: PubMed
    45. Richtand NM, Logue AD, Welge JA, Perdiue J, Tubbs LJ, Spitzer RH, Sethuraman G, Geracioti TD. The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine. Brain Res. 2000 Jun 09; 867(1-2):239-42. PMID: 10837819.
      View in: PubMed
    46. Koster NL, Norman AB, Richtand NM, Nickell WT, Puche AC, Pixley SK, Shipley MT. Olfactory receptor neurons express D2 dopamine receptors. J Comp Neurol. 1999 Sep 06; 411(4):666-73. PMID: 10421875.
      View in: PubMed
    47. Hondo H, Spitzer RH, Grinius B, Richtand NM. Quantification of dopamine D3 receptor mRNA level associated with the development of amphetamine-induced behavioral sensitization in the rat brain. Neurosci Lett. 1999 Apr 02; 264(1-3):69-72. PMID: 10320016.
      View in: PubMed
    48. Geracioti TD, Parker S, Lowther NB, Wortman M, Richtand NM. A case of treatment-refractory psychosis responsive to sertindole. Schizophr Res. 1998 Feb 27; 30(1):105-8. PMID: 9542794.
      View in: PubMed
    49. Geracioti TD, Goldsmith RJ, Friedman LM, Norman AB, Somoza E, Kasckow JW, Baker DG, Richtand NM, Anthenelli RM, Keck PE. Cerebrospinal fluid neuroendocrinology of alcohol misusers. Addict Biol. 1997 Oct; 2(4):401-10. PMID: 26735945.
      View in: PubMed
    50. Richtand NM, Kelsoe JR, Kuczenski R, Segal DS. Quantification of dopamine D1 and D2 receptor mRNA levels associated with the development of behavioral sensitization in amphetamine treated rats. Neurochem Int. 1997 Jul; 31(1):131-7. PMID: 9185173.
      View in: PubMed
    51. Geracioti TD, Loosen PT, Ekhator NN, Schmidt D, Chambliss B, Baker DG, Kasckow JW, Richtand NM, Keck PE, Ebert MH. Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. Depress Anxiety. 1997; 6(3):89-94. PMID: 9442982.
      View in: PubMed
    52. Richtand NM, Kelsoe JR, Segal DS, Kuczenski R. Regional quantification of dopamine transporter mRNA in rat brain using a ribonuclease protection assay. Neurosci Lett. 1995 Nov 17; 200(2):73-6. PMID: 8614566.
      View in: PubMed
    53. Richtand NM, Kelsoe JR, Segal DS, Kuczenski R. Regional quantification of D1, D2, and D3 dopamine receptor mRNA in rat brain using a ribonuclease protection assay. Brain Res Mol Brain Res. 1995 Oct; 33(1):97-103. PMID: 8774950.
      View in: PubMed
    Neil's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _