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Ralph Greenspan

Title(s)Professor In Residence, Cognitive Science
SchoolAcademic Aff
Phone858-822-7657
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    Collapse Research 
    Collapse Research Activities and Funding
    A Drosophila Model for Williams Syndrome Cognitive Processing
    NIH/NEI R21EY020629Sep 30, 2010 - Mar 31, 2012
    Role: Principal Investigator
    From Sleep to attention in Drosophila: Coordinating Brain Regions
    NIH/NIGMS R01GM087393Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator
    DEVELOPMENTAL GENETICS OF NEURAL TUBE FORMATION
    NIH/NICHD R01HD020083Apr 1, 1985 - Mar 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Aimon S, Katsuki T, Jia T, Grosenick L, Broxton M, Deisseroth K, Sejnowski TJ, Greenspan RJ. Fast near-whole-brain imaging in adult Drosophila during responses to stimuli and behavior. PLoS Biol. 2019 Feb; 17(2):e2006732. PMID: 30768592.
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    2. Gold DA, Katsuki T, Li Y, Yan X, Regulski M, Ibberson D, Holstein T, Steele RE, Jacobs DK, Greenspan RJ. The genome of the jellyfish Aurelia and the evolution of animal complexity. Nat Ecol Evol. 2019 01; 3(1):96-104. PMID: 30510179.
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    3. Srinivasan S, Greenspan RJ, Stevens CF, Grover D. Deep(er) Learning. J Neurosci. 2018 Aug 22; 38(34):7365-7374. PMID: 30006366.
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    4. Shultzaberger RK, Johnson SJ, Wagner J, Ha K, Markow TA, Greenspan RJ. Conservation of the behavioral and transcriptional response to social experience among Drosophilids. Genes Brain Behav. 2019 01; 18(1):e12487. PMID: 29797548.
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    5. Grover D, Katsuki T, Greenspan RJ. Flyception: imaging brain activity in freely walking fruit flies. Nat Methods. 2016 07; 13(7):569-72. PMID: 27183441.
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    6. Alivisatos AP, Chun M, Church GM, Greenspan RJ, Roukes ML, Yuste R. A National Network of Neurotechnology Centers for the BRAIN Initiative. Neuron. 2015 Nov 04; 88(3):445-8. PMID: 26481036.
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    7. Shultzaberger RK, Boyd JS, Diamond S, Greenspan RJ, Golden SS. Giving Time Purpose: The Synechococcus elongatus Clock in a Broader Network Context. Annu Rev Genet. 2015; 49:485-505. PMID: 26442846; PMCID: PMC4769874 [Available on 11/23/16].
    8. Shih CT, Sporns O, Yuan SL, Su TS, Lin YJ, Chuang CC, Wang TY, Lo CC, Greenspan RJ, Chiang AS. Connectomics-based analysis of information flow in the Drosophila brain. Curr Biol. 2015 May 18; 25(10):1249-58. PMID: 25866397.
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    9. Shultzaberger RK, Paddock ML, Katsuki T, Greenspan RJ, Golden SS. High-throughput and quantitative approaches for measuring circadian rhythms in cyanobacteria using bioluminescence. Methods Enzymol. 2015; 551:53-72. PMID: 25662451; PMCID: PMC4771492.
    10. Shultzaberger RK, Boyd JS, Katsuki T, Golden SS, Greenspan RJ. Single mutations in sasA enable a simpler ?cikA gene network architecture with equivalent circadian properties. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):E5069-75. PMID: 25385627; PMCID: PMC4250164.
    11. Sejnowski TJ, Poizner H, Lynch G, Gepshtein S, Greenspan RJ. Prospective Optimization. Proc IEEE Inst Electr Electron Eng. 2014 May; 102(5). PMID: 25328167.
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    12. Katsuki T, Greenspan RJ. Jellyfish nervous systems. Curr Biol. 2013 Jul 22; 23(14):R592-4. PMID: 23885868.
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    13. Katz P, Grillner S, Wilson R, Borst A, Greenspan R, Buzsáki G, Martin K, Marder E, Kristan W, Friedrich R, Chklovskii D. Vertebrate versus invertebrate neural circuits. Curr Biol. 2013 Jun 17; 23(12):R504-6. PMID: 23943928.
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    14. Lin CY, Chuang CC, Hua TE, Chen CC, Dickson BJ, Greenspan RJ, Chiang AS. A comprehensive wiring diagram of the protocerebral bridge for visual information processing in the Drosophila brain. Cell Rep. 2013 May 30; 3(5):1739-53. PMID: 23707064.
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    15. Alivisatos AP, Chun M, Church GM, Deisseroth K, Donoghue JP, Greenspan RJ, McEuen PL, Roukes ML, Sejnowski TJ, Weiss PS, Yuste R. Neuroscience. The brain activity map. Science. 2013 Mar 15; 339(6125):1284-5. PMID: 23470729; PMCID: PMC3722427.
    16. Greenspan RJ. Biological indeterminacy. Sci Eng Ethics. 2012 Sep; 18(3):447-52. PMID: 22752704.
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    17. Alivisatos AP, Chun M, Church GM, Greenspan RJ, Roukes ML, Yuste R. The brain activity map project and the challenge of functional connectomics. Neuron. 2012 Jun 21; 74(6):970-4. PMID: 22726828; PMCID: PMC3597383.
    18. Houot B, Fraichard S, Greenspan RJ, Ferveur JF. Genes involved in sex pheromone discrimination in Drosophila melanogaster and their background-dependent effect. PLoS One. 2012; 7(1):e30799. PMID: 22292044; PMCID: PMC3264623.
    19. Greenspan RJ. Selection, gene interaction, and flexible gene networks. Cold Spring Harb Symp Quant Biol. 2009; 74:131-8. PMID: 19903749.
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    20. Kent CF, Daskalchuk T, Cook L, Sokolowski MB, Greenspan RJ. The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation. PLoS Genet. 2009 Aug; 5(8):e1000609. PMID: 19696884.
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    21. Bohland JW, Wu C, Barbas H, Bokil H, Bota M, Breiter HC, Cline HT, Doyle JC, Freed PJ, Greenspan RJ, Haber SN, Hawrylycz M, Herrera DG, Hilgetag CC, Huang ZJ, Jones A, Jones EG, Karten HJ, Kleinfeld D, Kötter R, Lester HA, Lin JM, Mensh BD, Mikula S, Panksepp J, Price JL, Safdieh J, Saper CB, Schiff ND, Schmahmann JD, Stillman BW, Svoboda K, Swanson LW, Toga AW, Van Essen DC, Watson JD, Mitra PP. A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Comput Biol. 2009 Mar; 5(3):e1000334. PMID: 19325892; PMCID: PMC2655718.
    22. Andretic R, Kim YC, Jones FS, Han KA, Greenspan RJ. Drosophila D1 dopamine receptor mediates caffeine-induced arousal. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20392-7. PMID: 19074291; PMCID: PMC2629270.
    23. Greenspan RJ. The origins of behavioral genetics. Curr Biol. 2008 Mar 11; 18(5):R192-8. PMID: 18334190.
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    24. Greenspan RJ. Seymour Benzer (1921-2007). Curr Biol. 2008 Feb 12; 18(3):R106-10. PMID: 18345547.
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    25. Weber KE, Greenspan RJ, Chicoine DR, Fiorentino K, Thomas MH, Knight TL. Microarray analysis of replicate populations selected against a wing-shape correlation in Drosophila melanogaster. Genetics. 2008 Feb; 178(2):1093-108. PMID: 18245369.
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    26. Foltenyi K, Greenspan RJ, Newport JW. Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nat Neurosci. 2007 Sep; 10(9):1160-7. PMID: 17694052.
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    27. Dierick HA, Greenspan RJ. Serotonin and neuropeptide F have opposite modulatory effects on fly aggression. Nat Genet. 2007 May; 39(5):678-82. PMID: 17450142.
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    28. Foltenyi K, Andretic R, Newport JW, Greenspan RJ. Neurohormonal and neuromodulatory control of sleep in Drosophila. Cold Spring Harb Symp Quant Biol. 2007; 72:565-71. PMID: 18419316.
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    29. Kendler KS, Greenspan RJ. The nature of genetic influences on behavior: lessons from "simpler" organisms. Am J Psychiatry. 2006 Oct; 163(10):1683-94. PMID: 17012675.
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    30. Dierick HA, Greenspan RJ. Molecular analysis of flies selected for aggressive behavior. Nat Genet. 2006 Sep; 38(9):1023-31. PMID: 16906161.
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    31. Greenspan RJ. No critter left behind: an invertebrate renaissance. Curr Biol. 2005 Sep 06; 15(17):R671-2. PMID: 16139200.
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    32. Andretic R, van Swinderen B, Greenspan RJ. Dopaminergic modulation of arousal in Drosophila. Curr Biol. 2005 Jul 12; 15(13):1165-75. PMID: 16005288.
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    33. Greenspan RJ, Baars BJ. Consciousness eclipsed: Jacques Loeb, Ivan P. Pavlov, and the rise of reductionistic biology after 1900. Conscious Cogn. 2005 Mar; 14(1):219-30. PMID: 15766898.
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    34. van Swinderen B, Greenspan RJ. Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster. Genetics. 2005 Apr; 169(4):2151-63. PMID: 15687281.
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    35. Greenspan RJ, van Swinderen B. Cognitive consonance: complex brain functions in the fruit fly and its relatives. Trends Neurosci. 2004 Dec; 27(12):707-11. PMID: 15541510.
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    36. Greenspan RJ, Dierick HA. 'Am not I a fly like thee?' From genes in fruit flies to behavior in humans. Hum Mol Genet. 2004 Oct 01; 13 Spec No 2:R267-73. PMID: 15358734.
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    37. Broughton SJ, Kitamoto T, Greenspan RJ. Excitatory and inhibitory switches for courtship in the brain of Drosophila melanogaster. Curr Biol. 2004 Apr 06; 14(7):538-47. PMID: 15062094.
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    38. Greenspan RJ. Systems neurobiology without backbones. Curr Biol. 2004 Mar 09; 14(5):R177-9. PMID: 15028227.
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    39. van Swinderen B, Nitz DA, Greenspan RJ. Uncoupling of brain activity from movement defines arousal States in Drosophila. Curr Biol. 2004 Jan 20; 14(2):81-7. PMID: 14738728.
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    40. Greenspan RJ. E pluribus unum, ex uno plura: quantitative and single-gene perspectives on the study of behavior. Annu Rev Neurosci. 2004; 27:79-105. PMID: 15217327.
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    41. Greenspan RJ. The varieties of selectional experience in behavioral genetics. J Neurogenet. 2003 Oct-Dec; 17(4):241-70. PMID: 15204079.
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    42. Greenspan RJ. The 2003 Genetics Society of America Medal; Jeffrey C.Hall. Genetics. 2003 Aug; 164(4):1245-47. PMID: 15106661; PMCID: PMC1462664.
    43. van Swinderen B, Greenspan RJ. Salience modulates 20-30 Hz brain activity in Drosophila. Nat Neurosci. 2003 Jun; 6(6):579-86. PMID: 12717438.
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    44. Greenspan RJ. RNA and memory: from feeding to localization. Curr Biol. 2003 Feb 18; 13(4):R126-7. PMID: 12593811.
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    45. Broughton SJ, Tully T, Greenspan RJ. Conditioning deficits of CaM-kinase transgenic Drosophila melanogaster in a new excitatory courtship assay. J Neurogenet. 2003 Jan-Mar; 17(1):91-102. PMID: 14504030.
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    46. Nitz DA, van Swinderen B, Tononi G, Greenspan RJ. Electrophysiological correlates of rest and activity in Drosophila melanogaster. Curr Biol. 2002 Nov 19; 12(22):1934-40. PMID: 12445387.
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    47. Toma DP, White KP, Hirsch J, Greenspan RJ. Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait. Nat Genet. 2002 Aug; 31(4):349-53. PMID: 12042820.
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    48. Shaw PJ, Tononi G, Greenspan RJ, Robinson DF. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature. 2002 May 16; 417(6886):287-91. PMID: 12015603.
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    49. Greenspan RJ. The flexible genome. Nat Rev Genet. 2001 May; 2(5):383-7. PMID: 11331904.
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    50. Greenspan RJ, Tononi G, Cirelli C, Shaw PJ. Sleep and the fruit fly. Trends Neurosci. 2001 Mar; 24(3):142-5. PMID: 11182453.
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    51. Orgad S, Rosenfeld G, Greenspan RJ, Segal D. courtless, the Drosophila UBC7 homolog, is involved in male courtship behavior and spermatogenesis. Genetics. 2000 Jul; 155(3):1267-80. PMID: 10880487.
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    52. Shaw PJ, Cirelli C, Greenspan RJ, Tononi G. Correlates of sleep and waking in Drosophila melanogaster. Science. 2000 Mar 10; 287(5459):1834-7. PMID: 10710313.
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    53. Greenspan RJ, Ferveur JF. Courtship in Drosophila. Annu Rev Genet. 2000; 34:205-232. PMID: 11092827.
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    54. Staron RB, Greenspan R, Miller TT, Bilezikian JP, Shane E, Haramati N. Computerized bone densitometric analysis: operator-dependent errors. Radiology. 1999 May; 211(2):467-70. PMID: 10228530.
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    55. Ferveur JF, Greenspan RJ. Courtship behavior of brain mosaics in Drosophila. J Neurogenet. 1998 Nov; 12(4):205-26. PMID: 10656109.
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    56. Greenspan RJ. A kinder, gentler genetic analysis of behavior: dissection gives way to modulation. Curr Opin Neurobiol. 1997 Dec; 7(6):805-11. PMID: 9464983.
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    57. Osborne KA, Robichon A, Burgess E, Butland S, Shaw RA, Coulthard A, Pereira HS, Greenspan RJ, Sokolowski MB. Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. Science. 1997 Aug 08; 277(5327):834-6. PMID: 9242616.
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    58. Ferveur JF, Savarit F, O'Kane CJ, Sureau G, Greenspan RJ, Jallon JM. Genetic feminization of pheromones and its behavioral consequences in Drosophila males. Science. 1997 Jun 06; 276(5318):1555-8. PMID: 9171057.
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    59. Kane NS, Robichon A, Dickinson JA, Greenspan RJ. Learning without performance in PKC-deficient Drosophila. Neuron. 1997 Feb; 18(2):307-14. PMID: 9052800.
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    60. Broughton SJ, Kane NS, Yoder M, Greenspan RJ, Robichon A. Transport of CaM kinase along processes elicited by neuronal contact evokes an inhibition of arborization and outgrowth in D. melanogaster cultured neurons. J Cell Biochem. 1996 Sep 15; 62(4):484-94. PMID: 8891894.
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    61. Broughton SJ, Kane NS, Arthur B, Yoder M, Greenspan RJ, Robichon A. Endogenously inhibited protein kinase C in transgenic Drosophila embryonic neuroblasts down regulates the outgrowth of type I and II processes of cultured mature neurons. J Cell Biochem. 1996 Mar 15; 60(4):584-99. PMID: 8707897.
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    62. Greenspan RJ. Flies, genes, learning, and memory. Neuron. 1995 Oct; 15(4):747-50. PMID: 7576623.
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    63. Greenspan RJ. Understanding the genetic construction of behavior. Sci Am. 1995 Apr; 272(4):72-8. PMID: 7716488.
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    64. Ferveur JF, Störtkuhl KF, Stocker RF, Greenspan RJ. Genetic feminization of brain structures and changed sexual orientation in male Drosophila. Science. 1995 Feb 10; 267(5199):902-5. PMID: 7846534.
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    65. Wang J, Renger JJ, Griffith LC, Greenspan RJ, Wu CF. Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase II-inhibited synapses. Neuron. 1994 Dec; 13(6):1373-84. PMID: 7993628.
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    66. Griffith LC, Wang J, Zhong Y, Wu CF, Greenspan RJ. Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):10044-8. PMID: 7937834.
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    67. Griffith LC, Verselis LM, Aitken KM, Kyriacou CP, Danho W, Greenspan RJ. Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plasticity. Neuron. 1993 Mar; 10(3):501-9. PMID: 8384859.
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    68. Del Amo FF, Smith DE, Swiatek PJ, Gendron-Maguire M, Greenspan RJ, McMahon AP, Gridley T. Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development. 1992 Jul; 115(3):737-44. PMID: 1425352.
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    69. Hoppe PE, Greenspan RJ. The Notch locus of Drosophila is required in epidermal cells for epidermal development. Development. 1990 Aug; 109(4):875-85. PMID: 2226204.
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    70. Greenspan RJ. The Notch gene, adhesion, and developmental fate in the Drosophila embryo. New Biol. 1990 Jul; 2(7):595-600. PMID: 2083251.
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    71. Greenspan RJ, O'Brien MC. Genetic evidence for the role of Thy-1 in neurite outgrowth in the mouse. J Neurogenet. 1989 Jan; 5(1):25-36. PMID: 2564888.
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    72. Greenspan RJ, O'Brien MC. Genetic analysis of mutations at the fused locus in the mouse. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4413-7. PMID: 3459182.
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    73. Matthew WD, Greenspan RJ, Lander AD, Reichardt LF. Immunopurification and characterization of a neuronal heparan sulfate proteoglycan. J Neurosci. 1985 Jul; 5(7):1842-50. PMID: 3160834.
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    74. Quinn WG, Greenspan RJ. Learning and courtship in Drosophila: two stories with mutants. Annu Rev Neurosci. 1984; 7:67-93. PMID: 6143528.
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    75. Greenspan RJ, Finn JA, Hall JC. Acetylcholinesterase mutants in Drosophila and their effects on the structure and function of the central nervous system. J Comp Neurol. 1980 Feb 15; 189(4):741-74. PMID: 6769980.
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    76. Hall JC, Tompkins L, Kyriacou CP, Siegel RW, von Schilcher F, Greenspan RJ. Higher behavior in Drosophila analyzed with mutations that disrupt the structure and function of the nervous system. Basic Life Sci. 1980; 16:425-55. PMID: 6779805.
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    77. Hall JC, Greenspan RJ. Genetic analysis of Drosophila neurobiology. Annu Rev Genet. 1979; 13:127-95. PMID: 395893.
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    78. Friedman CM, Greenspan R, Mittleman F. The decision-making process and the outcome of therapeutic abortion. Am J Psychiatry. 1974 Dec; 131(12):1332-7. PMID: 4432932.
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