Benjamin Hoffman

Photo of Benjamin Hoffman
Title(s)RESID PHYS/SUBSPEC 4-8/REP, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-9831-4061 Additional info
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    Dr. Benjamin Hoffman is a physician-scientist working at the interface of neuroscience and cardiology. His research asks how the nervous system senses the heart—how mechanosensitive vagal neurons detect the heart's mechanical state and how that signal shapes cardiovascular health and disease. He aims to bring the neural control of the heart into molecular focus and to build precise, non-invasive neuromodulatory therapies on that foundation, bridging fundamental discovery in the laboratory with clinical trials in patients with arrhythmia and heart failure.

    Collapse Biography 
    Collapse education and training
    University of California, San Diego, La Jolla06/2028Cardiac Electrophysiology Fellowship
    Scripps Research, La Jolla06/2028Research Fellowship
    University of California, San Diego, La Jolla06/2026Cardiovascular Diseases Fellowship
    University of California, San Francisco, San Francisco06/2023Internal Medicine Residency
    Columbia University, New York CityM.D.04/2020Medicine
    Columbia University, New York CityPh.D.05/2019Neurobiology and Behavior
    Stanford University, StanfordB.S.06/2013Biology
    Collapse awards and honors
    University of California, San Diego2025  - 2026Faculty Award for Outstanding Cardiovascular Fellow
    University of California, San Diego2025  - 2026Chief Cardiology Fellow
    American College of Cardiology2025  - 2026American College of Cardiology (ACC)/ABC Merck Research Fellow
    Columbia University2019  - 2020Doctors William Nastuk, Beatrice Seegal, Konrad Hsu, and Louis P. Rowland Award

    Collapse Research 
    Collapse Featured Publications
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    The role of Piezo2-expressing vagal neurons in cardiovascular homeostasis and heart failure
    American College of Cardiology / Association of Black Cardiologists / Merck ACC/ABC Merck Research FellowshipJul 1, 2025 - Jun 30, 2026
    Role: Principal Investigator
    Description: The ACC/ABC Merck Research Fellowship provides $100,000 in salary support for one year of cardiovascular research and is awarded to three cardiology fellows nationally. This project tests the hypothesis that vagal sensory neurons expressing the mechanosensitive ion channel Piezo2 mediate cardiac mechanical interoception and modulate cardiovascular remodeling in heart failure, under the mentorship of Dr. Ardem Patapoutian at Scripps Research.
    Peripheral mechanisms of neurotransmission in mammalian touch receptors
    NIH F31NS105449Dec 1, 2017 - Nov 30, 2019
    Role: Principal Investigator
    Collapse Clinical Trials

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    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Seventy Seconds of Asystole: Delayed Atrioventricular Block Post-TAVR From His-Bundle Injury and Phase 4 Block. JACC Case Rep. 2026 Sep 11; 110318. Malladi CL, Hoffman BU, Ma G, Kim D, Reeves R, Ben-Yehuda O, Mahmud E, Hoffmayer KS, Hsu JC, Han FT. PMID: 42730733.
      View in: PubMed   Mentions:
    2. A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action. Compr Physiol. 2026 Apr; 16(2):e70109. Bu Y, Liang A, Hoffman BU, Schiehser DM, Case O, Simmons A, Klaming R, Gottfried-Blackmore A, Mittal RK, Puleo C, Lim H, Lerman I. PMID: 41781173; PMCID: PMC12960021.
      View in: PubMed   Mentions:    Fields:    
    3. TAVR for Asymptomatic Severe Aortic Stenosis. N Engl J Med. 2025 Jun 05; 392(21):2176-2177. Hoffman BU, Ben-Yehuda O. PMID: 40466075.
      View in: PubMed   Mentions: 1     Fields:    
    4. The cellular basis of mechanosensation in mammalian tongue. Cell Rep. 2023 02 28; 42(2):112087. Moayedi Y, Xu S, Obayashi SK, Hoffman BU, Gerling GJ, Lumpkin EA. PMID: 36763499; PMCID: PMC10409885.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. In vitro production of infectious Plasmodium falciparum sporozoites. Nature. 2022 12; 612(7940):534-539. Eappen AG, Li T, Marquette M, Chakravarty S, Kc N, Zanghi G, Hoffman BU, Hettiarachchi H, Patil A, Abebe Y, Tran C, Yossef AA, McWilliams I, Morrison RD, Rathakrishnan A, Inbar E, Aly ASI, De La Vega P, Belmonte M, Sedegah M, Wai T, Campo JJ, King H, Kappe SHI, Li M, Billingsley PF, Sim BKL, Hoffman SL. PMID: 36477528.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    6. Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2. Proc Natl Acad Sci U S A. 2022 05 24; 119(21):e2115821119. Hoffman BU, Baba Y, Lee SA, Tong CK, Konofagou EE, Lumpkin EA. PMID: 35580186; PMCID: PMC9173751.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    7. Significant relaxation of SARS-CoV-2-targeted non-pharmaceutical interventions may result in profound mortality: A New York state modelling study. PLoS One. 2020; 15(9):e0239647. Hoffman BU. PMID: 32970745; PMCID: PMC7514073.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    8. Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses. Neuron. 2018 12 19; 100(6):1401-1413.e6. Hoffman BU, Baba Y, Griffith TN, Mosharov EV, Woo SH, Roybal DD, Karsenty G, Patapoutian A, Sulzer D, Lumpkin EA. PMID: 30415995; PMCID: PMC6347413.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    9. A gut feeling. Science. 2018 09 21; 361(6408):1203-1204. Hoffman BU, Lumpkin EA. PMID: 30237346.
      View in: PubMed   Mentions: 5     Fields:    
    10. Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes. PLoS Comput Biol. 2018 06; 14(6):e1006264. Gerling GJ, Wan L, Hoffman BU, Wang Y, Lumpkin EA. PMID: 29958280; PMCID: PMC6042796.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    11. The signaling lipid sphingosine 1-phosphate regulates mechanical pain. Elife. 2018 03 21; 7. Hill RZ, Hoffman BU, Morita T, Campos SM, Lumpkin EA, Brem RB, Bautista DM. PMID: 29561262; PMCID: PMC5896955.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    12. Plasmodium falciparum: effect of radiation on levels of gene transcripts in sporozoites. Exp Parasitol. 2008 Feb; 118(2):247-52. Hoffman BU, Chattopadhyay R. PMID: 17935717.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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