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    Tariq Rana

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0762
    CA La Jolla 92093
    Phone858-246-1100
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Regulation of HIV-1 Replication by Cellular IncRNAs
      NIH/NIAID R21AI125103Aug 5, 2016 - Jul 31, 2018
      Role: Principal Investigator
      Modeling HIV/AIDS Associated Neurological Disorders with Human Pluripotent Cells
      NIH/NIDA DP1DA039562Mar 1, 2015 - Jan 31, 2020
      Role: Principal Investigator
      Innate Immune Responses and Vaccines Against Tumor-Associated Herpesviruses
      NIH P01CA177322Sep 19, 2014 - Aug 31, 2019
      Role: Co-Investigator
      Preclinical Development of HIV-1 Vif Antagonists
      NIH P01MH100942Aug 19, 2013 - Jul 31, 2018
      Role: Co-Investigator
      Regulation of HIV infection by Methamphetamine and non-coding RNAs
      NIH/NIDA R01DA030199Jul 15, 2010 - Feb 28, 2015
      Role: Principal Investigator
      RNAi-Based Therapy of ALS
      NIH/NINDS R01NS060856Aug 5, 2009 - Jul 31, 2012
      Role: Principal Investigator
      Preclinical Development of HIV-1 Vif Antagonists
      NIH U19MH081836Apr 16, 2007 - Mar 31, 2013
      Role: Co-Investigator
      TARGETING HIV VIF PROTEIN
      NIH/NIAID R21AI054181Sep 30, 2002 - Aug 31, 2004
      Role: Principal Investigator
      Targeting Ensembles of Drug Resistant HIV-Protease
      NIH P01GM066524Aug 20, 2002 - Aug 31, 2013
      Role: Co-Investigator
      INHIBITION OF HIV REPLICATION
      NIH/NIAID R01AI045466Jul 1, 2000 - Jun 30, 2004
      Role: Principal Investigator
      INHIBITION OF HIV REPLICATION
      NIH/NIAID R21AI045466Sep 30, 1999 - Sep 30, 2000
      Role: Principal Investigator
      Mechanisms of innate immunity against HIV
      NIH/NIAID R01AI043198Jun 1, 1998 - Jan 31, 2015
      Role: Principal Investigator
      Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
      NIH/NIAID R01AI041404Sep 1, 1997 - Jun 30, 2016
      Role: Principal Investigator
      Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
      NIH/NIAID R56AI041404Sep 1, 1997 - Aug 31, 2010
      Role: Principal Investigator
      STRUCTURE OF CHEMICALLY MODIFIED TAT-TAR COMPLEX
      NIH/FIC R03TW000702Jul 1, 1996 - Jun 30, 1999
      Role: Principal Investigator
      PROBING TAT TAR INTERACTIONS IN HIV BY CHEMICAL METHODS
      NIH/NIAID K02AI001369Apr 1, 1996 - Mar 31, 2001
      Role: Principal Investigator
      TAT-TAR INTERACTIONS IN HIV PROBED BY CHEMICAL METHODS
      NIH/NIAID R29AI034785Jul 15, 1993 - Jun 30, 1998
      Role: Principal Investigator
      Cancer Center Support Grant (CCSG)
      NIH/NCI P30CA030199Jul 1, 1981 - Apr 30, 2020
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Tiwari SK, Dang J, Qin Y, Lichinchi G, Bansal V, Rana T. Zika virus infection reprograms global transcription of host cells to allow sustained infection. Emerg Microbes Infect. 2017 Apr 26; 6(4):e24. PMID: 28442752.
        View in: PubMed
      2. Xiong XP, Kurthkoti K, Chang KY, Li JL, Ren X, Ni JQ, Rana T, Zhou R. miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila. PLoS Pathog. 2016 Nov; 12(11):e1006034. PMID: 27893816.
        View in: PubMed
      3. Gong D, Kim YH, Xiao Y, Du Y, Xie Y, Lee KK, Feng J, Farhat N, Zhao D, Shu S, Dai X, Chanda SK, Rana T, Krogan NJ, Sun R, Wu TT. A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export. Cell Host Microbe. 2016 Nov 9; 20(5):642-653. PMID: 27832591.
        View in: PubMed
      4. Han T, Yang CS, Chang KY, Zhang D, Imam FB, Rana T. Identification of novel genes and networks governing hematopoietic stem cell development. EMBO Rep. 2016 Oct 26. PMID: 27797851.
        View in: PubMed
      5. Lichinchi G, Zhao BS, Wu Y, Lu Z, Qin Y, He C, Rana T. Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Oct 18. PMID: 27773536.
        View in: PubMed
      6. Zhou Y, Dang J, Chang KY, Yau E, Aza-Blanc P, Moscat J, Rana T. miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3. Cancer Res. 2016 Oct 1; 76(19):5777-5787. PMID: 27698189.
        View in: PubMed
      7. Mohammed I, Kummetha IR, Singh G, Sharova N, Lichinchi G, Dang J, Stevenson M, Rana T. 1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists. J Med Chem. 2016 Aug 25; 59(16):7677-82. PMID: 27509004.
        View in: PubMed
      8. Yang CS, Chang KY, Dang J, Rana T. Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity. Sci Rep. 2016; 6:26899. PMID: 27247273.
        View in: PubMed
      9. Johnson TC, Chin MR, Han T, Shen JP, Rana T, Siegel D. Synthesis of Eupalinilide E, a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion. J Am Chem Soc. 2016 May 11; 138(18):6068-73. PMID: 27096704.
        View in: PubMed
      10. Lichinchi G, Gao S, Saletore Y, Gonzalez GM, Bansal V, Wang Y, Mason CE, Rana T. Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016; 1:16011. PMID: 27572442.
        View in: PubMed
      11. Dang J, Rana T. Enhancing Induced Pluripotent Stem Cell Generation by MicroRNA. Methods Mol Biol. 2016; 1357:71-84. PMID: 25687299.
        View in: PubMed
      12. Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana T, Geyer M, Tong L, Shokat KM, Fisher RP. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Dev. 2016 Jan 1; 30(1):117-31. PMID: 26728557.
        View in: PubMed
      13. McCarroll JA, Dwarte T, Baigude H, Dang J, Yang L, Erlich RB, Kimpton K, Teo J, Sagnella SM, Akerfeldt MC, Liu J, Phillips PA, Rana T, Kavallaris M. Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer. Oncotarget. 2015 May 20; 6(14):12020-34. PMID: 25557168.
        View in: PubMed
      14. Lin N, Dang J, Rana T. Haunting the HOXA Locus: Two Faces of lncRNA Regulation. Cell Stem Cell. 2015 May 7; 16(5):449-50. PMID: 25957895.
        View in: PubMed
      15. Baigude H, Rana T. Strategies to antagonize miRNA functions in vitro and in vivo. Nanomedicine (Lond). 2014 Nov; 9(16):2545-55. PMID: 25490425.
        View in: PubMed
      16. Li Z, Dang J, Chang KY, Rana T. MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming. RNA. 2014 Dec; 20(12):1900-15. PMID: 25336587.
        View in: PubMed
      17. Han J, Cai J, Borjihan W, Ganbold T, Rana T, Baigude H. Preparation of novel curdlan nanoparticles for intracellular siRNA delivery. Carbohydr Polym. 2015 Mar 6; 117:324-30. PMID: 25498642.
        View in: PubMed
      18. Li Z, Rana T. Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation. RNA Biol. 2014 Aug 3; 11(8):979-85. PMID: 25482890.
        View in: PubMed
      19. Yang CS, Chang KY, Rana T. Genome-wide Functional Analysis Reveals Factors Needed at the Transition Steps of Induced Reprogramming. Cell Rep. 2014 Jul 24; 8(2):327-37. PMID: 25043178.
        View in: PubMed
      20. Li Z, Rana T. Therapeutic targeting of microRNAs: current status and future challenges. Nat Rev Drug Discov. 2014 Aug; 13(8):622-38. PMID: 25011539.
        View in: PubMed
      21. Sakurai K, Talukdar I, Patil VS, Dang J, Li Z, Chang KY, Lu CC, Delorme-Walker V, Dermardirossian C, Anderson K, Hanein D, Yang CS, Wu D, Liu Y, Rana T. Kinome-wide Functional Analysis Highlights the Role of Cytoskeletal Remodeling in Somatic Cell Reprogramming. Cell Stem Cell. 2014 Apr 3; 14(4):523-34. PMID: 24702998.
        View in: PubMed
      22. Lin N, Chang KY, Li Z, Gates K, Rana ZA, Dang J, Zhang D, Han T, Yang CS, Cunningham TJ, Head SR, Duester G, Dong PD, Rana T. An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment. Mol Cell. 2014 Mar 20; 53(6):1005-19. PMID: 24530304.
        View in: PubMed
      23. Henzler CM, Li Z, Dang J, Arcila ML, Zhou H, Liu J, Chang KY, Bassett DS, Rana T, Kosik KS. Staged miRNA re-regulation patterns during reprogramming. Genome Biol. 2013; 14(12):R149. PMID: 24380417.
        View in: PubMed
      24. Li Z, Chao TC, Chang KY, Lin N, Patil VS, Shimizu C, Head SR, Burns JC, Rana T. The long noncoding RNA THRIL regulates TNFa expression through its interaction with hnRNPL. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1002-7. PMID: 24371310.
        View in: PubMed
      25. Patil VS, Zhou R, Rana T. Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol. 2014 Jan-Feb; 49(1):16-32. PMID: 24164576.
        View in: PubMed
      26. Shen Y, Altman MD, Ali A, Nalam MN, Cao H, Rana T, Schiffer CA, Tidor B. Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol. 2013 Nov 15; 8(11):2433-41. PMID: 23952265.
        View in: PubMed
      27. Xiong XP, Kurthkoti K, Chang KY, Lichinchi G, De N, Schneemann A, MacRae IJ, Rana T, Perrimon N, Zhou R. Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proc Natl Acad Sci U S A. 2013 Oct 8; 110(41):16520-5. PMID: 24067655.
        View in: PubMed
      28. Nalam MN, Ali A, Reddy GS, Cao H, Anjum SG, Altman MD, Yilmaz NK, Tidor B, Rana T, Schiffer CA. Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem Biol. 2013 Sep 19; 20(9):1116-24. PMID: 24012370.
        View in: PubMed
      29. Silver NW, King BM, Nalam MN, Cao H, Ali A, Kiran Kumar Reddy GS, Rana T, Schiffer CA, Tidor B. Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration. J Chem Theory Comput. 2013 Nov 12; 9(11):5098-5115. PMID: 24250277.
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      30. Baigude H, Su J, McCarroll J, Rana T. In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs). ACS Med Chem Lett. 2013 Aug 8; 4(8):720-723. PMID: 24319542.
        View in: PubMed
      31. Zhou R, Rana T. RNA-based mechanisms regulating host-virus interactions. Immunol Rev. 2013 May; 253(1):97-111. PMID: 23550641.
        View in: PubMed
      32. Yang CS, Rana T. Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst. 2013 Jan 27; 9(1):10-7. PMID: 23037570.
        View in: PubMed
      33. Parai MK, Huggins DJ, Cao H, Nalam MN, Ali A, Schiffer CA, Tidor B, Rana T. Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem. 2012 Jul 26; 55(14):6328-41. PMID: 22708897.
        View in: PubMed
      34. Mohammed I, Parai MK, Jiang X, Sharova N, Singh G, Stevenson M, Rana T. SAR and Lead Optimization of an HIV-1 Vif-APOBEC3G Axis Inhibitor. ACS Med Chem Lett. 2012 Jun 14; 3(6):465-469. PMID: 24533175.
        View in: PubMed
      35. Baigude H. miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets. Angew Chem Int Ed Engl. 2012 Jun 11; 51(24):5880-3. PMID: 22566243.
        View in: PubMed
      36. Ali A, Wang J, Nathans RS, Cao H, Sharova N, Stevenson M, Rana T. Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication. ChemMedChem. 2012 Jul; 7(7):1217-29. PMID: 22555953.
        View in: PubMed
      37. Zhou H, Arcila ML, Li Z, Lee EJ, Henzler C, Liu J, Rana T, Kosik KS. Deep annotation of mouse iso-miR and iso-moR variation. Nucleic Acids Res. 2012 Jul; 40(13):5864-75. PMID: 22434881.
        View in: PubMed
      38. Li Z, Rana T. Molecular mechanisms of RNA-triggered gene silencing machineries. Acc Chem Res. 2012 Jul 17; 45(7):1122-31. PMID: 22304792.
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      39. Li Z, Rana T. Using microRNAs to enhance the generation of induced pluripotent stem cells. Curr Protoc Stem Cell Biol. 2012; Chapter 4:Unit 4A.4. PMID: 22415842.
        View in: PubMed
      40. O'Brien SK, Knight KL, Rana T. Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation. J Cell Physiol. 2012 Jan; 227(1):383-9. PMID: 21503884.
        View in: PubMed
      41. Baigude H, Rana T. Interfering nanoparticles for silencing microRNAs. Methods Enzymol. 2012; 509:339-53. PMID: 22568914.
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      42. Li Z, Rana T. A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun. 2012; 3:1085. PMID: 23011139.
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      43. Yang CS, Lopez CG, Rana T. Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation. Stem Cells. 2011 Oct; 29(10):1528-36. PMID: 21898684.
        View in: PubMed
      44. Yang CS, Li Z, Rana T. microRNAs modulate iPS cell generation. RNA. 2011 Aug; 17(8):1451-60. PMID: 21693621.
        View in: PubMed
      45. Li Z, Yang CS, Nakashima K, Rana T. Small RNA-mediated regulation of iPS cell generation. EMBO J. 2011 Mar 2; 30(5):823-34. PMID: 21285944.
        View in: PubMed
      46. Su J, Baigude H, McCarroll J, Rana T. Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Res. 2011 Mar; 39(6):e38. PMID: 21212128.
        View in: PubMed
      47. Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Schiffer CA, Rana T. Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones. J Med Chem. 2010 Nov 11; 53(21):7699-708. PMID: 20958050.
        View in: PubMed
      48. Lu CC, Li Z, Chu CY, Feng J, Feng J, Sun R, Rana T. MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle. EMBO Rep. 2010 Oct; 11(10):784-90. PMID: 20847741.
        View in: PubMed
      49. Ghosh A, Mukherjee K, Jiang X, Zhou Y, McCarroll J, Qu J, Swain PM, Baigude H, Rana T. Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines. Bioconjug Chem. 2010 Sep 15; 21(9):1581-7. PMID: 20722369.
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      50. James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana T, Morley SJ, Longmore GD, Bushell M, Sharp TV. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12499-504. PMID: 20616046.
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      51. O'Brien SK, Cao H, Nathans R, Ali A, Rana T. P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes. J Biol Chem. 2010 Sep 24; 285(39):29713-20. PMID: 20551309.
        View in: PubMed
      52. Nalam MN, Ali A, Altman MD, Reddy GS, Chellappan S, Kairys V, Ozen A, Cao H, Gilson MK, Tidor B, Rana T, Schiffer CA. Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance. J Virol. 2010 May; 84(10):5368-78. PMID: 20237088.
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      53. McCarroll J, Baigude H, Yang CS, Rana T. Nanotubes functionalized with lipids and natural amino acid dendrimers: a new strategy to create nanomaterials for delivering systemic RNAi. Bioconjug Chem. 2010 Jan; 21(1):56-63. PMID: 19957956.
        View in: PubMed
      54. Das S, Pan D, Bera AK, Rana T, Bandyopadhyay S, De S, Das SK, Bhattacharya D, Bandyopadhyay SK. Stress inducible heat shock protein 70: a potent molecular and toxicological signature in arsenic exposed broiler chickens. Mol Biol Rep. 2010 Oct; 37(7):3151-5. PMID: 19826909.
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      55. Baigude H, Rana T. Delivery of therapeutic RNAi by nanovehicles. Chembiochem. 2009 Oct 12; 10(15):2449-54. PMID: 19688785.
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      56. Pan D, Bera AK, Das S, Bandyopadhyay S, Rana T, Bandyopadhyay S, Das SK, Bhattacharya D. Use of zinc chloride as alternative stimulant for in vitro study of nitric oxide production pathway in avian splenocyte culture. Mol Biol Rep. 2010 Jun; 37(5):2223-6. PMID: 19690983.
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      57. Ali A, Ghosh A, Nathans RS, Sharova N, O'Brien S, Cao H, Stevenson M, Rana T. Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication. Chembiochem. 2009 Aug 17; 10(12):2072-80. PMID: 19603446.
        View in: PubMed
      58. Nathans R, Chu CY, Serquina AK, Lu CC, Cao H, Rana T. Cellular microRNA and P bodies modulate host-HIV-1 interactions. Mol Cell. 2009 Jun 26; 34(6):696-709. PMID: 19560422.
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      59. Bélanger F, Baigude H, Rana T. U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex. J Mol Biol. 2009 Mar 6; 386(4):1094-107. PMID: 19244621.
        View in: PubMed
      60. Jorissen RN, Reddy GS, Ali A, Altman MD, Chellappan S, Anjum SG, Tidor B, Schiffer CA, Rana T, Gilson MK. Additivity in the analysis and design of HIV protease inhibitors. J Med Chem. 2009 Feb 12; 52(3):737-54. PMID: 19193159.
        View in: PubMed
      61. Nathans R, Cao H, Sharova N, Ali A, Sharkey M, Stranska R, Stevenson M, Rana T. Small-molecule inhibition of HIV-1 Vif. Nat Biotechnol. 2008 Oct; 26(10):1187-92. PMID: 18806783.
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      62. Cao H, Yang CS, Rana T. Evolutionary emergence of microRNAs in human embryonic stem cells. PLoS One. 2008; 3(7):e2820. PMID: 18665260.
        View in: PubMed
      63. Chu CY, Rana T. Potent RNAi by short RNA triggers. RNA. 2008 Sep; 14(9):1714-9. PMID: 18658119.
        View in: PubMed
      64. Altman MD, Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Chellappan S, Kairys V, Fernandes MX, Gilson MK, Schiffer CA, Rana T, Tidor B. HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants. J Am Chem Soc. 2008 May 14; 130(19):6099-113. PMID: 18412349.
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      65. Wang H, Ghosh A, Baigude H, Yang CS, Qiu L, Xia X, Zhou H, Rana T, Xu Z. Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. J Biol Chem. 2008 Jun 6; 283(23):15845-52. PMID: 18367449.
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      66. Chu CY, Rana T. Small RNAs: regulators and guardians of the genome. J Cell Physiol. 2007 Nov; 213(2):412-9. PMID: 17674365.
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      67. Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Nathans RS, Schiffer CA, Rana T. Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres. J Med Chem. 2007 Sep 6; 50(18):4316-28. PMID: 17696512.
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      68. Robb GB, Rana T. RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol Cell. 2007 May 25; 26(4):523-37. PMID: 17531811.
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      69. Chellappan S, Kiran Kumar Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Kairys V, Fernandes MX, Altman MD, Tidor B, Rana T, Schiffer CA, Gilson MK. Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis. Chem Biol Drug Des. 2007 May; 69(5):298-313. PMID: 17539822.
        View in: PubMed
      70. Baigude H, McCarroll J, Yang CS, Swain PM, Rana T. Design and creation of new nanomaterials for therapeutic RNAi. ACS Chem Biol. 2007 Apr 24; 2(4):237-41. PMID: 17432823.
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      71. Chiu YL, Cao H, Rana T. Quantitative analysis of RNA-mediated protein-protein interactions in living cells by FRET. Chem Biol Drug Des. 2007 Apr; 69(4):233-9. PMID: 17461970.
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      72. Rana T. Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol. 2007 Jan; 8(1):23-36. PMID: 17183358.
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      73. Ali A, Reddy GS, Cao H, Anjum SG, Nalam MN, Schiffer CA, Rana T. Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands. J Med Chem. 2006 Dec 14; 49(25):7342-56. PMID: 17149864.
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      74. Richter SN, Bélanger F, Zheng P, Rana T. Dynamics of nascent mRNA folding and RNA-protein interactions: an alternative TAR RNA structure is involved in the control of HIV-1 mRNA transcription. Nucleic Acids Res. 2006; 34(15):4278-92. PMID: 16920743.
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      75. Chu CY, Rana T. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol. 2006 Jul; 4(7):e210. PMID: 16756390.
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      76. Wichroski MJ, Robb GB, Rana T. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog. 2006 May; 2(5):e41. PMID: 16699599.
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      77. Cao H, Tamilarasu N, Rana T. Orientation and affinity of HIV-1 Tat fragments in Tat-TAR complex determined by fluorescence resonance energy transfer. Bioconjug Chem. 2006 Mar-Apr; 17(2):352-8. PMID: 16536465.
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      78. Lee CW, Cao H, Ichiyama K, Rana T. Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine. Bioorg Med Chem Lett. 2005 Oct 1; 15(19):4243-6. PMID: 16054360.
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      79. Chiu YL, Dinesh CU, Chu CY, Ali A, Brown KM, Cao H, Rana T. Dissecting RNA-interference pathway with small molecules. Chem Biol. 2005 Jun; 12(6):643-8. PMID: 15975509.
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      80. Brown KM, Chu CY, Rana T. Target accessibility dictates the potency of human RISC. Nat Struct Mol Biol. 2005 May; 12(5):469-70. PMID: 15852021.
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      81. Lee HK, Cao H, Rana T. Design, microwave-assisted synthesis, and photophysical properties of small molecule organic antennas for luminescence resonance energy transfer. J Comb Chem. 2005 Mar-Apr; 7(2):279-84. PMID: 15762757.
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      82. Ping YH, Rana T. Mechanism of site-specific psoralen photoadducts formation in triplex DNA directed by psoralen-conjugated oligonucleotides. Biochemistry. 2005 Feb 22; 44(7):2501-9. PMID: 15709762.
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      83. Robb GB, Brown KM, Khurana J, Rana T. Specific and potent RNAi in the nucleus of human cells. Nat Struct Mol Biol. 2005 Feb; 12(2):133-7. PMID: 15643423.
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      84. Ping YH, Chu CY, Cao H, Jacque JM, Stevenson M, Rana T. Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology. 2004; 1:46. PMID: 15620346.
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      85. Wichroski MJ, Ichiyama K, Rana T. Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G: correlating function and subcellular localization. J Biol Chem. 2005 Mar 4; 280(9):8387-96. PMID: 15537645.
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      86. Chiu YL, Ali A, Chu CY, Cao H, Rana T. Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol. 2004 Aug; 11(8):1165-75. PMID: 15324818.
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      87. Zhang L, Rana T. Solid-phase synthesis of alpha-(2-(benzylthio)-1,4-dihydro-6-methyl-4-p-tolylpyrimidine-5-carboxamido) acids: a new strategy to create diversity in heterocyclic scaffolds. J Comb Chem. 2004 Jul-Aug; 6(4):457-9. PMID: 15244403.
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      88. Lee HK, Rana T. Microwave-assisted parallel synthesis of a 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine library. J Comb Chem. 2004 Jul-Aug; 6(4):504-8. PMID: 15244411.
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      89. Chiu YL, Cao H, Jacque JM, Stevenson M, Rana T. Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1). J Virol. 2004 Mar; 78(5):2517-29. PMID: 14963154.
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      90. Gelman MA, Richter S, Cao H, Umezawa N, Gellman SH, Rana T. Selective binding of TAR RNA by a Tat-derived beta-peptide. Org Lett. 2003 Oct 2; 5(20):3563-5. PMID: 14507173.
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      91. Chiu YL, Rana T. siRNA function in RNAi: a chemical modification analysis. RNA. 2003 Sep; 9(9):1034-48. PMID: 12923253.
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      92. Hwang S, Tamilarasu N, Kibler K, Cao H, Ali A, Ping YH, Jeang KT, Rana T. Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication. J Biol Chem. 2003 Oct 3; 278(40):39092-103. PMID: 12857725.
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      93. Hamma T, Saleh A, Huq I, Rana T, Miller PS. Inhibition of HIV tat-TAR interactions by an antisense oligo-2'-O-methylribonucleoside methylphosphonate. Bioorg Med Chem Lett. 2003 Jun 2; 13(11):1845-8. PMID: 12749881.
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      94. Kesavan V, Tamilarasu N, Cao H, Rana T. A new class of RNA-binding oligomers: peptoid amide and ester analogues. Bioconjug Chem. 2002 Nov-Dec; 13(6):1171-5. PMID: 12440849.
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      95. Chiu YL, Rana T. RNAi in human cells: basic structural and functional features of small interfering RNA. Mol Cell. 2002 Sep; 10(3):549-61. PMID: 12408823.
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      96. Chiu YL, Ho CK, Saha N, Schwer B, Shuman S, Rana T. Tat stimulates cotranscriptional capping of HIV mRNA. Mol Cell. 2002 Sep; 10(3):585-97. PMID: 12408826.
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      97. Zhou C, Rana T. A bimolecular mechanism of HIV-1 Tat protein interaction with RNA polymerase II transcription elongation complexes. J Mol Biol. 2002 Jul 26; 320(5):925-42. PMID: 12126615.
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      98. Richter S, Ping YH, Rana T. TAR RNA loop: a scaffold for the assembly of a regulatory switch in HIV replication. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):7928-33. PMID: 12048247.
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      99. Richter S, Cao H, Rana T. Specific HIV-1 TAR RNA loop sequence and functional groups are required for human cyclin T1-Tat-TAR ternary complex formation. Biochemistry. 2002 May 21; 41(20):6391-7. PMID: 12009901.
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      100. Dinman JD, Richter S, Plant EP, Taylor RC, Hammell AB, Rana T. The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5331-6. PMID: 11959986.
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      101. Wang Z, Shah K, Rana T. Probing Tat peptide-TAR RNA interactions by psoralen photo-cross-linking. Biochemistry. 2001 May 29; 40(21):6458-64. PMID: 11371209.
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      102. O'Brien TP, Li QJ, Sauerburger F, Reviglio VE, Rana T, Ashraf MF. The role of matrix metalloproteinases in ulcerative keratolysis associated with perioperative diclofenac use. Ophthalmology. 2001 Apr; 108(4):656-9. PMID: 11297478.
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      103. Tamilarasu N, Zhang J, Hwang S, Rana T. A new strategy for site-specific protein modification: analysis of a Tat peptide-TAR RNA interaction. Bioconjug Chem. 2001 Mar-Apr; 12(2):135-8. PMID: 11312672.
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      104. Tamilarasu N, Huq I, Rana T. Targeting RNA with peptidomimetic oligomers in human cells. Bioorg Med Chem Lett. 2001 Feb 26; 11(4):505-7. PMID: 11229758.
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      105. Chiu YL, Coronel E, Ho CK, Shuman S, Rana T. HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA. J Biol Chem. 2001 Apr 20; 276(16):12959-66. PMID: 11278368.
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      106. Ping YH, Rana T. DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation. J Biol Chem. 2001 Apr 20; 276(16):12951-8. PMID: 11112772.
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      107. Zhang J, Tamilarasu N, Hwang S, Garber ME, Huq I, Jones KA, Rana T. HIV-1 TAR RNA enhances the interaction between Tat and cyclin T1. J Biol Chem. 2000 Nov 3; 275(44):34314-9. PMID: 10944537.
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      108. Tamilarasu N, Huq I, Rana T. Design, synthesis, and biological activity of a cyclic peptide: an inhibitor of HIV-1 tat-TAR interactions in human cells. Bioorg Med Chem Lett. 2000 May 1; 10(9):971-4. PMID: 10853671.
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      109. Hwang S, Tamilarasu N, Rana T. Selection of HIV replication inhibitors: chemistry and biology. Adv Pharmacol. 2000; 49:167-97. PMID: 11013764.
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      110. Hwang S, Tamilarasu N, Ryan K, Huq I, Richter S, Still WC, Rana T. Inhibition of gene expression in human cells through small molecule-RNA interactions. Proc Natl Acad Sci U S A. 1999 Nov 9; 96(23):12997-3002. PMID: 10557261.
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      111. Rana T, Jeang KT. Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA. Arch Biochem Biophys. 1999 May 15; 365(2):175-85. PMID: 10328810.
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      112. Wang Z, Huq I, Rana T. Proximity of a Tat peptide to the HIV-1 TAR RNA loop region determined by site-specific photo-cross-linking. Bioconjug Chem. 1999 May-Jun; 10(3):512-9. PMID: 10346885.
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      113. Huq I, Ping YH, Tamilarasu N, Rana T. Controlling human immunodeficiency virus type 1 gene expression by unnatural peptides. Biochemistry. 1999 Apr 20; 38(16):5172-7. PMID: 10213623.
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      114. Ping YH, Rana T. Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes. J Biol Chem. 1999 Mar 12; 274(11):7399-404. PMID: 10066804.
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      115. Huq I, Tamilarasu N, Rana T. Visualizing tertiary folding of RNA and RNA-protein interactions by a tethered iron chelate: analysis ofHIV-1 Tat-TAR complex. Nucleic Acids Res. 1999 Feb 15; 27(4):1084-93. PMID: 9927743.
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      116. Wang Z, Rana T. Probing RNA-protein interactions by psoralen photocrosslinking. Methods Mol Biol. 1999; 118:49-62. PMID: 10549514.
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      117. Wang Z, Rana T. RNA-protein interactions in the Tat-trans-activation response element complex determined by site-specific photo-cross-linking. Biochemistry. 1998 Mar 24; 37(12):4235-43. PMID: 9521746.
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      118. Huq I, Wang X, Rana T. Specific recognition of HIV-1 TAR RNA by a D-Tat peptide. Nat Struct Biol. 1997 Nov; 4(11):881-2. PMID: 9360598.
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      119. Huq I, Rana T. Probing the proximity of the core domain of an HIV-1 Tat fragment in a Tat-TAR complex by affinity cleaving. Biochemistry. 1997 Oct 14; 36(41):12592-9. PMID: 9376365.
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      120. Ping YH, Liu Y, Wang X, Neenhold HR, Rana T. Dynamics of RNA-protein interactions in the HIV-1 Rev-RRE complex visualized by 6-thioguanosine-mediated photocrosslinking. RNA. 1997 Aug; 3(8):850-60. PMID: 9257644.
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      121. Wang Z, Rana T. DNA damage-dependent transcriptional arrest and termination of RNA polymerase II elongation complexes in DNA template containing HIV-1 promoter. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6688-93. PMID: 9192626.
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      122. Song AI, Rana T. Synthesis of an amino acid analogue to incorporate p-aminobenzyl-EDTA in peptides. Bioconjug Chem. 1997 Mar-Apr; 8(2):249-52. PMID: 9095368.
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      123. Wang Z, Wang X, Rana T. Protein orientation in the Tat-TAR complex determined by psoralen photocross-linking. J Biol Chem. 1996 Jul 19; 271(29):16995-8. PMID: 8663586.
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      124. Wang Z, Rana T. RNA conformation in the Tat-TAR complex determined by site-specific photo-cross-linking. Biochemistry. 1996 May 21; 35(20):6491-9. PMID: 8639596.
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      125. Shah K, Neenhold H, Wang Z, Rana T. Incorporation of an artificial protease and nuclease at the HIV-1 Tat binding site of trans-activation responsive RNA. Bioconjug Chem. 1996 May-Jun; 7(3):283-9. PMID: 8816949.
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      126. Liu Y, Wang Z, Rana T. Visualizing a specific contact in the HIV-1 Tat protein fragment and trans-activation responsive region RNA complex by photocross-linking. J Biol Chem. 1996 Apr 26; 271(17):10391-6. PMID: 8626612.
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      127. Neenhold HR, Rana T. Major groove opening at the HIV-1 Tat binding site of TAR RNA evidenced by a rhodium probe. Biochemistry. 1995 May 16; 34(19):6303-9. PMID: 7756257.
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      128. Shah K, Wu H, Rana T. Synthesis of uridine phosphoramidite analogs: reagents for site-specific incorporation of photoreactive sites into RNA sequences. Bioconjug Chem. 1994 Nov-Dec; 5(6):508-12. PMID: 7533002.
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      129. Rana T, Meares CF. N-terminal modification of immunoglobulin polypeptide chains tagged with isothiocyanato chelates. Bioconjug Chem. 1990 Sep-Oct; 1(5):357-62. PMID: 2129106.
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