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    Sheng Zhong

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-246-1118
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Mapping RNA interactomes by sequencing
      NIH DP1HD087990Sep 30, 2015 - Jul 31, 2020
      Role: Principal Investigator
      The Organizational Hub and Web Portal for the 4D Nucleome Network
      NIH U01CA200147Sep 1, 2015 - Aug 31, 2020
      Role: Principal Investigator
      Non-coding Variants Predisposing to Age-related Macular Degeneration
      NIH R01HG008135Aug 24, 2015 - Jun 30, 2018
      Role: Principal Investigator
      Evolutionary models for gene regulatory networks
      NIH DP2OD007417Sep 30, 2010 - Aug 31, 2015
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Sridhar B, Rivas-Astroza M, Nguyen TC, Chen W, Yan Z, Cao X, Hebert L, Zhong S. Systematic Mapping of RNA-Chromatin Interactions In Vivo. Curr Biol. 2017 Feb 20; 27(4):610-612. PMID: 28222283.
        View in: PubMed
      2. Sridhar B, Rivas-Astroza M, Nguyen TC, Chen W, Yan Z, Cao X, Hebert L, Zhong S. Systematic Mapping of RNA-Chromatin Interactions In Vivo. Curr Biol. 2017 Jan 25. PMID: 28132817.
        View in: PubMed
      3. Zhang H, Fei R, Xue B, Yu S, Zhang Z, Zhong S, Gao Y, Zhou X. Pnserpin: A Novel Serine Protease Inhibitor from Extremophile Pyrobaculum neutrophilum. Int J Mol Sci. 2017 Jan 07; 18(1). PMID: 28067849.
        View in: PubMed
      4. Nguyen TC, Cao X, Yu P, Xiao S, Lu J, Biase FH, Sridhar B, Huang N, Zhang K, Zhong S. Mapping RNA-RNA interactome and RNA structure in vivo by MARIO. Nat Commun. 2016; 7:12023. PMID: 27338251.
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      5. Zhang Y, Cao X, Zhong S. GeNemo: a search engine for web-based functional genomic data. Nucleic Acids Res. 2016 Jul 8; 44(W1):W122-7. PMID: 27098038.
        View in: PubMed
      6. Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell. 2015 Sep 17; 59(6):931-40. PMID: 26365380.
        View in: PubMed
      7. Sears KE, Maier JA, Rivas-Astroza M, Poe R, Zhong S, Kosog K, Marcot JD, Behringer RR, Cretekos CJ, Rasweiler JJ, Rapti Z. The Relationship between Gene Network Structure and Expression Variation among Individuals and Species. PLoS Genet. 2015 Aug; 11(8):e1005398. PMID: 26317994.
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      8. Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel GA, Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou XQ, Pazin MJ, Feingold EA, Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos JA, Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer MA, Ren B. A comparative encyclopedia of DNA elements in the mouse genome. Nature. 2014 Nov 20; 515(7527):355-64. PMID: 25409824.
        View in: PubMed
      9. Huang W, Cao X, Biase FH, Yu P, Zhong S. Time-variant clustering model for understanding cell fate decisions. Proc Natl Acad Sci U S A. 2014 Nov 4; 111(44):E4797-806. PMID: 25339442.
        View in: PubMed
      10. Biase FH, Cao X, Zhong S. Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing. Genome Res. 2014 Nov; 24(11):1787-96. PMID: 25096407.
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      11. Xiao S, Cao X, Zhong S. Comparative epigenomics: defining and utilizing epigenomic variations across species, time-course, and individuals. Wiley Interdiscip Rev Syst Biol Med. 2014 Sep; 6(5):345-52. PMID: 25044241.
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      12. Shi Y, Zhong S. From genomes to societies: a holistic view of determinants of human health. Curr Opin Biotechnol. 2014 Aug; 28:134-42. PMID: 24686286.
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      13. Chen CC, Xiao S, Xie D, Cao X, Song CX, Wang T, He C, Zhong S. Understanding variation in transcription factor binding by modeling transcription factor genome-epigenome interactions. PLoS Comput Biol. 2013 Dec; 9(12):e1003367. PMID: 24339764.
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      14. Cingolani P, Cao X, Khetani RS, Chen CC, Coon M, Sammak A, Bollig-Fischer A, Land S, Huang Y, Hudson ME, Garfinkel MD, Zhong S, Robinson GE, Ruden DM. Intronic Non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees. BMC Genomics. 2013; 14:666. PMID: 24079845.
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      15. Cao X, Zhong S. Enabling interspecies epigenomic comparison with CEpBrowser. Bioinformatics. 2013 May 1; 29(9):1223-5. PMID: 23543396.
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      16. Yu P, Xiao S, Xin X, Song CX, Huang W, McDee D, Tanaka T, Wang T, He C, Zhong S. Spatiotemporal clustering of the epigenome reveals rules of dynamic gene regulation. Genome Res. 2013 Feb; 23(2):352-64. PMID: 23033340.
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      17. Zelin E, Zhang Y, Toogun OA, Zhong S, Freeman BC. The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. Mol Cell. 2012 Nov 9; 48(3):459-70. PMID: 23022381; NIHMSID: NIHMS407395.
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      18. Xiao S, Xie D, Cao X, Yu P, Xing X, Chen CC, Musselman M, Xie M, West FD, Lewin HA, Wang T, Zhong S. Comparative epigenomic annotation of regulatory DNA. Cell. 2012 Jun 8; 149(6):1381-92. PMID: 22682255.
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      19. Sears KE, Patel A, Hübler M, Cao X, Vandeberg JL, Zhong S. Disparate Igf1 expression and growth in the fore- and hind limbs of a marsupial mammal (Monodelphis domestica). J Exp Zool B Mol Dev Evol. 2012 Jun; 318(4):279-93. PMID: 22821864.
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      20. Lee J, Seok S, Yu P, Kim K, Smith Z, Rivas-Astroza M, Zhong S, Kemper JK. Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice. Hepatology. 2012 Jul; 56(1):108-17. PMID: 22278336.
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      21. Rivas-Astroza M, Xie D, Cao X, Zhong S. Mapping personal functional data to personal genomes. Bioinformatics. 2011 Dec 15; 27(24):3427-9. PMID: 22006915.
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      22. Xie D, Chen CC, He X, Cao X, Zhong S. Towards an evolutionary model of transcription networks. PLoS Comput Biol. 2011 Jun; 7(6):e1002064. PMID: 21695281.
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      23. Huang W, Cao X, Zhong S. Network-based comparison of temporal gene expression patterns. Bioinformatics. 2010 Dec 1; 26(23):2944-51. PMID: 20889495.
        View in: PubMed
      24. Shi L, Campbell G, Jones WD, Campagne F, Wen Z, Walker SJ, Su Z, Chu TM, Goodsaid FM, Pusztai L, Shaughnessy JD, Oberthuer A, Thomas RS, Paules RS, Fielden M, Barlogie B, Chen W, Du P, Fischer M, Furlanello C, Gallas BD, Ge X, Megherbi DB, Symmans WF, Wang MD, Zhang J, Bitter H, Brors B, Bushel PR, Bylesjo M, Chen M, Cheng J, Cheng J, Chou J, Davison TS, Delorenzi M, Deng Y, Devanarayan V, Dix DJ, Dopazo J, Dorff KC, Elloumi F, Fan J, Fan S, Fan X, Fang H, Gonzaludo N, Hess KR, Hong H, Huan J, Irizarry RA, Judson R, Juraeva D, Lababidi S, Lambert CG, Li L, Li Y, Li Z, Lin SM, Liu G, Lobenhofer EK, Luo J, Luo W, McCall MN, Nikolsky Y, Pennello GA, Perkins RG, Philip R, Popovici V, Price ND, Qian F, Scherer A, Shi T, Shi W, Sung J, Thierry-Mieg D, Thierry-Mieg J, Thodima V, Trygg J, Vishnuvajjala L, Wang SJ, Wu J, Wu Y, Xie Q, Yousef WA, Zhang L, Zhang X, Zhong S, Zhou Y, Zhu S, Arasappan D, Bao W, Lucas AB, Berthold F, Brennan RJ, Buness A, Catalano JG, Chang C, Chen R, Cheng Y, Cui J, Czika W, Demichelis F, Deng X, Dosymbekov D, Eils R, Feng Y, Fostel J, Fulmer-Smentek S, Fuscoe JC, Gatto L, Ge W, Goldstein DR, Guo L, Halbert DN, Han J, Harris SC, Hatzis C, Herman D, Huang J, Jensen RV, Jiang R, Johnson CD, Jurman G, Kahlert Y, Khuder SA, Kohl M, Li J, Li L, Li M, Li QZ, Li S, Li Z, Liu J, Liu Y, Liu Z, Meng L, Madera M, Martinez-Murillo F, Medina I, Meehan J, Miclaus K, Moffitt RA, Montaner D, Mukherjee P, Mulligan GJ, Neville P, Nikolskaya T, Ning B, Page GP, Parker J, Parry RM, Peng X, Peterson RL, Phan JH, Quanz B, Ren Y, Riccadonna S, Roter AH, Samuelson FW, Schumacher MM, Shambaugh JD, Shi Q, Shippy R, Si S, Smalter A, Sotiriou C, Soukup M, Staedtler F, Steiner G, Stokes TH, Sun Q, Tan PY, Tang R, Tezak Z, Thorn B, Tsyganova M, Turpaz Y, Vega SC, Visintainer R, von Frese J, Wang C, Wang E, Wang J, Wang W, Westermann F, Willey JC, Woods M, Wu S, Xiao N, Xu J, Xu L, Yang L, Zeng X, Zhang J, Zhang L, Zhang M, Zhao C, Puri RK, Scherf U, Tong W, Wolfinger RD. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol. 2010 Aug; 28(8):827-38. PMID: 20676074.
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      25. Cai J, Xie D, Fan Z, Chipperfield H, Marden J, Wong WH, Zhong S. Modeling co-expression across species for complex traits: insights to the difference of human and mouse embryonic stem cells. PLoS Comput Biol. 2010 Mar 12; 6(3):e1000707. PMID: 20300647; PMCID: PMC2837392.
      26. Xie D, Chen CC, Ptaszek LM, Xiao S, Cao X, Fang F, Ng HH, Lewin HA, Cowan C, Zhong S. Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species. Genome Res. 2010 Jun; 20(6):804-15. PMID: 20219939.
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      27. Hong F, Fang F, He X, Cao X, Chipperfield H, Xie D, Wong WH, Ng HH, Zhong S. Dissecting early differentially expressed genes in a mixture of differentiating embryonic stem cells. PLoS Comput Biol. 2009 Dec; 5(12):e1000607. PMID: 20019792.
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      28. Chen CC, Zhong S. Inferring gene regulatory networks by thermodynamic modeling. BMC Genomics. 2008; 9 Suppl 2:S19. PMID: 18831784.
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      29. Shi L, Jones WD, Jensen RV, Harris SC, Perkins RG, Goodsaid FM, Guo L, Croner LJ, Boysen C, Fang H, Qian F, Amur S, Bao W, Barbacioru CC, Bertholet V, Cao XM, Chu TM, Collins PJ, Fan XH, Frueh FW, Fuscoe JC, Guo X, Han J, Herman D, Hong H, Kawasaki ES, Li QZ, Luo Y, Ma Y, Mei N, Peterson RL, Puri RK, Shippy R, Su Z, Sun YA, Sun H, Thorn B, Turpaz Y, Wang C, Wang SJ, Warrington JA, Willey JC, Wu J, Xie Q, Zhang L, Zhang L, Zhong S, Wolfinger RD, Tong W. The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics. 2008; 9 Suppl 9:S10. PMID: 18793455.
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      30. Xie D, Cai J, Chia NY, Ng HH, Zhong S. Cross-species de novo identification of cis-regulatory modules with GibbsModule: application to gene regulation in embryonic stem cells. Genome Res. 2008 Aug; 18(8):1325-35. PMID: 18490265.
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      31. Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, Robson P, Zhong S, Ng HH. A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol. 2008 Mar; 10(3):353-60. PMID: 18264089.
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      32. Chen CC, Zhu XG, Zhong S. Selection of thermodynamic models for combinatorial control of multiple transcription factors in early differentiation of embryonic stem cells. BMC Genomics. 2008; 9 Suppl 1:S18. PMID: 18366607; PMCID: PMC2386060.
      33. Zhong S, Xie D. Gene Ontology analysis in multiple gene clusters under multiple hypothesis testing framework. Artif Intell Med. 2007 Oct; 41(2):105-15. PMID: 17913480.
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      34. Lu Y, He X, Zhong S. Cross-species microarray analysis with the OSCAR system suggests an INSR->Pax6->NQO1 neuro-protective pathway in aging and Alzheimer's disease. Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W105-14. PMID: 17545194; PMCID: PMC1933158.
      35. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol. 2006 Sep; 24(9):1151-61. PMID: 16964229.
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      36. Ai L, Tao Q, Zhong S, Fields CR, Kim WJ, Lee MW, Cui Y, Brown KD, Robertson KD. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis. 2006 Jul; 27(7):1341-8. PMID: 16501252.
        View in: PubMed
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