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    Robert Abraham

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0719
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Roles of ATM and ATR Kinases in DNA Damage Responses
      NIH/NCI R01CA097950Mar 1, 2002 - Feb 28, 2007
      Role: Co-Principal Investigator
      Cellular Pharmacology of Rapamycin
      NIH/NCI R01CA076193Dec 8, 1997 - Feb 28, 2009
      Role: Co-Principal Investigator
      SIGNAL TRANSDUCTION FROM THE T CELL ANTIGEN RECEPTOR
      NIH/NIGMS R01GM047286May 1, 1992 - Jul 31, 2005
      Role: Principal Investigator
      Cancer Center Support Grant (CCSG)
      NIH/NCI P30CA030199Jul 1, 1981 - Apr 30, 2020
      Role: Co-Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham R. The PI3K Pathway in Human Disease. Cell. 2017 Aug 10; 170(4):605-635. PMID: 28802037.
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      2. Emmanuel N, Ragunathan S, Shan Q, Wang F, Giannakou A, Huser N, Jin G, Myers J, Abraham R, Unsal-Kacmaz K. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 Jun 27; 19(13):2665-2680. PMID: 28658616.
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      3. Lu S, Sung T, Lin N, Abraham R, Jessen BA. Lysosomal adaptation: How cells respond to lysosomotropic compounds. PLoS One. 2017; 12(3):e0173771. PMID: 28301521.
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      4. Ihle NT, Abraham R. The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration. Mol Cell. 2017 Mar 16; 65(6):959-960. PMID: 28306509.
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      5. Abraham R. 4E-BP2 hardwires lymphocytes for rapamycin sensitivity. Sci Signal. 2016; 9(430):fs10. PMID: 27245610.
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      6. Abraham R. Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation. Cell Metab. 2016 Mar 8; 23(3):397-8. PMID: 26959180.
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      7. Eng CH, Wang Z, Tkach D, Toral-Barza L, Ugwonali S, Liu S, Fitzgerald SL, George E, Frias E, Cochran N, De Jesus R, McAllister G, Hoffman GR, Bray K, Lemon L, Lucas J, Fantin VR, Abraham R, Murphy LO, Nyfeler B. Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. Proc Natl Acad Sci U S A. 2016 Jan 5; 113(1):182-7. PMID: 26677873.
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      8. VanArsdale T, Boshoff C, Arndt KT, Abraham R. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1; 21(13):2905-10. PMID: 25941111.
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      9. Strohecker AM, Joshi S, Possemato R, Abraham R, Sabatini DM, White E. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene. 2015 Nov 5; 34(45):5662-76. PMID: 25772235.
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      10. Abraham R. Cell biology. Making sense of amino acid sensing. Science. 2015 Jan 9; 347(6218):128-9. PMID: 25574008.
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      11. Singh RR, Patel KP, Routbort MJ, Aldape K, Lu X, Manekia J, Abraham R, Reddy NG, Barkoh BA, Veliyathu J, Medeiros LJ, Luthra R. Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours. Br J Cancer. 2014 Nov 11; 111(10):2014-23. PMID: 25314059.
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      12. Shanware NP, Bray K, Eng CH, Wang F, Follettie M, Myers J, Fantin VR, Abraham R. Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion. Nat Commun. 2014; 5:4900. PMID: 25254627.
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      13. Abraham R. Too Little mTORC1 Activity Injures the Liver. Cell Metab. 2014 Jul 1; 20(1):4-6. PMID: 24988455.
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      14. Rejto PA, Abraham R. MTOR Mutations in the Crosshairs of Targeted Therapy. Cancer Discov. 2014 May; 4(5):513-5. PMID: 24795009.
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      15. Fantin VR, Abraham R. Self-eating limits EGFR-dependent tumor growth. Cell. 2013 Sep 12; 154(6):1184-6. PMID: 24034240.
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      16. Gerber HP, Koehn FE, Abraham R. The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics. Nat Prod Rep. 2013 May; 30(5):625-39. PMID: 23525375.
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      17. Shanware NP, Bray K, Abraham R. The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease. Annu Rev Pharmacol Toxicol. 2013; 53:89-106. PMID: 23294306.
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      18. Abraham R. Chemokine to the rescue: interleukin-8 mediates resistance to PI3K-pathway-targeted therapy in breast cancer. Cancer Cell. 2012 Dec 11; 22(6):703-5. PMID: 23238010.
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      19. Sapra P, Damelin M, Dijoseph J, Marquette K, Geles KG, Golas J, Dougher M, Narayanan B, Giannakou A, Khandke K, Dushin R, Ernstoff E, Lucas J, Leal M, Hu G, O'Donnell CJ, Tchistiakova L, Abraham R, Gerber HP. Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells. Mol Cancer Ther. 2013 Jan; 12(1):38-47. PMID: 23223830.
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      20. Bagrodia S, Smeal T, Abraham R. Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies. Pigment Cell Melanoma Res. 2012 Nov; 25(6):819-31. PMID: 22883054.
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      21. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham R, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
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      22. Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, Stretton A, Jones N, Gerrish A, Chapman J, Ivanov D, Moskvina V, Lovestone S, Priotsi P, Lupton M, Brayne C, Gill M, Lawlor B, Lynch A, Craig D, McGuinness B, Johnston J, Holmes C, Livingston G, Bass NJ, Gurling H, McQuillin A. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Mol Psychiatry. 2012 Dec; 17(12):1316-27. PMID: 22005930.
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      23. Dann SG, Abraham R. Serine biosynthesis: fuel for the melanoma cell growth engine. Pigment Cell Melanoma Res. 2011 Oct; 24(5):875-7. PMID: 22081811.
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      24. Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, Ohno S, Yamashita A, Abraham R, Gueven N, Lavin MF. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol. 2011 Nov; 31(22):4417-29. PMID: 21911475.
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      25. Wang X, Zhan Y, Zhao L, Alvarez J, Chaudhary I, Zhou BB, Abraham R, Feuerstein GZ. Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian target of rapamycin inhibitor, temsirolimus, in a preclinical mammary carcinoma OncoMouse model: a translational medicine study in support for early clinical development. J Pharmacol Exp Ther. 2011 Nov; 339(2):421-9. PMID: 21835932.
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      26. Eng CH, Abraham R. The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming. Oncogene. 2011 Nov 24; 30(47):4687-96. PMID: 21666712.
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      27. Damelin M, Geles KG, Follettie MT, Yuan P, Baxter M, Golas J, DiJoseph JF, Karnoub M, Huang S, Diesl V, Behrens C, Choe SE, Rios C, Gruzas J, Sridharan L, Dougher M, Kunz A, Hamann PR, Evans D, Armellino D, Khandke K, Marquette K, Tchistiakova L, Boghaert ER, Abraham R, Wistuba II, Zhou BB. Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells. Cancer Res. 2011 Jun 15; 71(12):4236-46. PMID: 21540235.
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      28. Shanware NP, Mullen AR, DeBerardinis RJ, Abraham R. Glutamine: pleiotropic roles in tumor growth and stress resistance. J Mol Med (Berl). 2011 Mar; 89(3):229-36. PMID: 21301794.
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      29. Eng CH, Abraham R. Glutaminolysis yields a metabolic by-product that stimulates autophagy. Autophagy. 2010 Oct; 6(7):968-70. PMID: 20724823.
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      30. Abraham R, Eng CH. A metabolic (re-)balancing act. Mol Cell. 2010 May 28; 38(4):481-2. PMID: 20513422.
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      31. Abraham R. Lysosomal Rag-ulation of mTOR complex 1 activity. Cell Metab. 2010 May 5; 11(5):341-2. PMID: 20444413.
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      32. Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham R, Carbone M, Lotze MT. Cancer and inflammation: promise for biologic therapy. J Immunother. 2010 May; 33(4):335-51. PMID: 20386472.
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      33. Eng CH, Yu K, Lucas J, White E, Abraham R. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal. 2010; 3(119):ra31. PMID: 20424262.
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      34. Venkatesan AM, Dehnhardt CM, Delos Santos E, Chen Z, Dos Santos O, Ayral-Kaloustian S, Khafizova G, Brooijmans N, Mallon R, Hollander I, Feldberg L, Lucas J, Yu K, Gibbons J, Abraham R, Chaudhary I, Mansour TS. Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor. J Med Chem. 2010 Mar 25; 53(6):2636-45. PMID: 20166697.
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      35. Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang TH, Cordeiro-Stone M, Kaufmann WK, Abraham R, Sancar A, Unsal-Kaçmaz K. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem. 2010 May 28; 285(22):16562-71. PMID: 20233725.
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      36. Dehnhardt CM, Venkatesan AM, Delos Santos E, Chen Z, Santos O, Ayral-Kaloustian S, Brooijmans N, Mallon R, Hollander I, Feldberg L, Lucas J, Chaudhary I, Yu K, Gibbons J, Abraham R, Mansour TS. Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402. J Med Chem. 2010 Jan 28; 53(2):798-810. PMID: 19968288.
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      37. Yu K, Shi C, Toral-Barza L, Lucas J, Shor B, Kim JE, Zhang WG, Mahoney R, Gaydos C, Tardio L, Kim SK, Conant R, Curran K, Kaplan J, Verheijen J, Ayral-Kaloustian S, Mansour TS, Abraham R, Zask A, Gibbons JJ. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res. 2010 Jan 15; 70(2):621-31. PMID: 20068177.
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      38. Shor B, Gibbons JJ, Abraham R, Yu K. Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle. 2009 Dec; 8(23):3831-7. PMID: 19901542.
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      39. Venkatesan AM, Dehnhardt CM, Chen Z, Santos ED, Dos Santos O, Bursavich M, Gilbert AM, Ellingboe JW, Ayral-Kaloustian S, Khafizova G, Brooijmans N, Mallon R, Hollander I, Feldberg L, Lucas J, Yu K, Gibbons J, Abraham R, Mansour TS. Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):653-6. PMID: 19954970.
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      40. Gibbons JJ, Abraham R, Yu K. Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol. 2009 Dec; 36 Suppl 3:S3-S17. PMID: 19963098.
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      41. Zhang YW, Brognard J, Coughlin C, You Z, Dolled-Filhart M, Aslanian A, Manning G, Abraham R, Hunter T. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell. 2009 Aug 28; 35(4):442-53. PMID: 19716789.
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      42. Zask A, Verheijen JC, Curran K, Kaplan J, Richard DJ, Nowak P, Malwitz DJ, Brooijmans N, Bard J, Svenson K, Lucas J, Toral-Barza L, Zhang WG, Hollander I, Gibbons JJ, Abraham R, Ayral-Kaloustian S, Mansour TS, Yu K. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27; 52(16):5013-6. PMID: 19645448.
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      43. Gavriil M, Tsao CC, Mandiyan S, Arndt K, Abraham R, Zhang Y. Specific IKKbeta inhibitor IV blocks Streptonigrin-induced NF-kappaB activity and potentiates its cytotoxic effect on cancer cells. Mol Carcinog. 2009 Aug; 48(8):678-84. PMID: 19444813.
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      44. Abraham R. GOLPH3 links the Golgi network to mTOR signaling and human cancer. Pigment Cell Melanoma Res. 2009 Aug; 22(4):378-9. PMID: 19624311.
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      45. Lau E, Chiang GG, Abraham R, Jiang W. Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival. Mol Biol Cell. 2009 Sep; 20(17):3953-64. PMID: 19587119.
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      46. Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham R, Nowak P, Zask A. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1; 69(15):6232-40. PMID: 19584280.
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      47. Sims R, Hollingworth P, Moskvina V, Dowzell K, O'Donovan MC, Powell J, Lovestone S, Brayne C, Rubinsztein D, Owen MJ, Williams J, Abraham R. Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease. Neurosci Lett. 2009 Sep 11; 461(1):54-9. PMID: 19477230.
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      48. Abraham R. Regulation of the mTOR signaling pathway: from laboratory bench to bedside and back again. F1000 Biol Rep. 2009; 1:8. PMID: 20948608.
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      49. Morgan AR, Hollingworth P, Abraham R, Lovestone S, Brayne C, Rubinsztein DC, Lynch A, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J. Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample. Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5; 150B(1):61-4. PMID: 18452187.
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      50. Zhang Y, Gavriil M, Lucas J, Mandiyan S, Follettie M, Diesl V, Sum FW, Powell D, Haney S, Abraham R, Arndt K. IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model. Cancer Res. 2008 Nov 15; 68(22):9519-24. PMID: 19010928.
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      51. Morgan AR, Hamilton G, Turic D, Jehu L, Harold D, Abraham R, Hollingworth P, Moskvina V, Brayne C, Rubinsztein DC, Lynch A, Lawlor B, Gill M, O'Donovan M, Powell J, Lovestone S, Williams J, Owen MJ. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5; 147B(6):727-31. PMID: 18163421.
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      52. Berstein G, Abraham R. Moving out: mobilizing activated T cells from lymphoid tissues. Nat Immunol. 2008 May; 9(5):455-7. PMID: 18425096.
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      53. Shor B, Zhang WG, Toral-Barza L, Lucas J, Abraham R, Gibbons JJ, Yu K. A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis. Cancer Res. 2008 Apr 15; 68(8):2934-43. PMID: 18413763.
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      54. Shen WH, Chen Z, Shi S, Chen H, Zhu W, Penner A, Bu G, Li W, Boyle DW, Rubart M, Field LJ, Abraham R, Liechty EA, Shou W. Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function. J Biol Chem. 2008 May 16; 283(20):13842-9. PMID: 18326485.
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      55. Oliveira V, Romanow WJ, Geisen C, Otterness DM, Mercurio F, Wang HG, Dalton WS, Abraham R. A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2008 May 9; 283(19):13174-84. PMID: 18326048.
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      56. Amornphimoltham P, Patel V, Leelahavanichkul K, Abraham R, Gutkind JS. A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. Cancer Res. 2008 Feb 15; 68(4):1144-53. PMID: 18281490.
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      57. Abraham R, Eng CH. Mammalian target of rapamycin as a therapeutic target in oncology. Expert Opin Ther Targets. 2008 Feb; 12(2):209-22. PMID: 18208369.
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      58. Toral-Barza L, Zhang WG, Huang X, McDonald LA, Salaski EJ, Barbieri LR, Ding WD, Krishnamurthy G, Hu YB, Lucas J, Bernan VS, Cai P, Levin JI, Mansour TS, Gibbons JJ, Abraham R, Yu K. Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines. Mol Cancer Ther. 2007 Nov; 6(11):3028-38. PMID: 17989320.
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      59. Chiang GG, Abraham R. Targeting the mTOR signaling network in cancer. Trends Mol Med. 2007 Oct; 13(10):433-42. PMID: 17905659.
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      60. Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, Abraham R. The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol Cancer Ther. 2007 Sep; 6(9):2505-14. PMID: 17766839.
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      61. Kosco KA, Cerignoli F, Williams S, Abraham R, Mustelin T. SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. Mol Immunol. 2008 Jan; 45(2):510-22. PMID: 17658605.
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      62. Abraham R, Gibbons JJ. The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res. 2007 Jun 1; 13(11):3109-14. PMID: 17545512.
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      63. Nakayama K, Gazdoiu S, Abraham R, Pan ZQ, Ronai Z. Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2. Biochem J. 2007 Jan 1; 401(1):217-26. PMID: 16958618.
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      64. Liu K, Hipkens S, Yang T, Abraham R, Zhang W, Chopra N, Knollmann B, Magnuson MA, Roden DM. Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels. Genesis. 2006 Nov; 44(11):556-64. PMID: 17083109.
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      65. Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham R, Pellecchia M. The FRB domain of mTOR: NMR solution structure and inhibitor design. Biochemistry. 2006 Aug 29; 45(34):10294-302. PMID: 16922504.
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      66. Abraham R. Signalomic signatures enlighten drug profiling. Nat Chem Biol. 2006 Jun; 2(6):295-6. PMID: 16710334.
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      67. Lau E, Zhu C, Abraham R, Jiang W. The functional role of Cdc6 in S-G2/M in mammalian cells. EMBO Rep. 2006 Apr; 7(4):425-30. PMID: 16439999.
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      68. Zhang YW, Hunter T, Abraham R. Turning the replication checkpoint on and off. Cell Cycle. 2006 Jan; 5(2):125-8. PMID: 16357541.
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      69. Gamero AM, Potla R, Sakamoto S, Baker DP, Abraham R, Larner AC. Type I interferons activate apoptosis in a Jurkat cell variant by caspase-dependent and independent mechanisms. Cell Signal. 2006 Aug; 18(8):1299-308. PMID: 16337360.
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      70. Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, Mercurio F, Abraham R. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell. 2005 Sep 2; 19(5):607-18. PMID: 16137618.
        View in: PubMed
      71. Ihle NT, Paine-Murrieta G, Berggren MI, Baker A, Tate WR, Wipf P, Abraham R, Kirkpatrick DL, Powis G. The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther. 2005 Sep; 4(9):1349-57. PMID: 16170026.
        View in: PubMed
      72. Liu M, Howes A, Lesperance J, Stallcup WB, Hauser CA, Kadoya K, Oshima RG, Abraham R. Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer. Cancer Res. 2005 Jun 15; 65(12):5325-36. PMID: 15958580.
        View in: PubMed
      73. Chiang GG, Abraham R. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem. 2005 Jul 8; 280(27):25485-90. PMID: 15899889.
        View in: PubMed
      74. Phee H, Abraham R, Weiss A. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol. 2005 Jun; 6(6):608-17. PMID: 15864311.
        View in: PubMed
      75. Abraham R, Tibbetts RS. Cell biology. Guiding ATM to broken DNA. Science. 2005 Apr 22; 308(5721):510-1. PMID: 15845843.
        View in: PubMed
      76. Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham R, Jiang W. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell. 2005 Jul; 16(7):3187-99. PMID: 15843429.
        View in: PubMed
      77. Abraham R. Part-time cop nabs deviant DNA. Nat Med. 2005 Mar; 11(3):257-8. PMID: 15746937.
        View in: PubMed
      78. Abraham R. TOR signaling: an odyssey from cellular stress to the cell growth machinery. Curr Biol. 2005 Feb 22; 15(4):R139-41. PMID: 15723787.
        View in: PubMed
      79. Abraham R. MAPKAP kinase-2: three's company at the G(2) checkpoint. Mol Cell. 2005 Jan 21; 17(2):163-4. PMID: 15664183.
        View in: PubMed
      80. Tsao CC, Geisen C, Abraham R. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J. 2004 Nov 24; 23(23):4660-9. PMID: 15538388.
        View in: PubMed
      81. Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham R, Shokat KM. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 1; 12(17):4749-59. PMID: 15358300.
        View in: PubMed
      82. Abraham R. The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):919-25. PMID: 15279777.
        View in: PubMed
      83. Abraham R. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):883-7. PMID: 15279773.
        View in: PubMed
      84. Fang Y, Tsao CC, Goodman BK, Furumai R, Tirado CA, Abraham R, Wang XF. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J. 2004 Aug 4; 23(15):3164-74. PMID: 15282542.
        View in: PubMed
      85. Ihle NT, Williams R, Chow S, Chew W, Berggren MI, Paine-Murrieta G, Minion DJ, Halter RJ, Wipf P, Abraham R, Kirkpatrick L, Powis G. Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther. 2004 Jul; 3(7):763-72. PMID: 15252137.
        View in: PubMed
      86. Wipf P, Minion DJ, Halter RJ, Berggren MI, Ho CB, Chiang GG, Kirkpatrick L, Abraham R, Powis G. Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin. Org Biomol Chem. 2004 Jul 7; 2(13):1911-20. PMID: 15227545.
        View in: PubMed
      87. Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham R. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell. 2004 Jun 4; 14(5):585-98. PMID: 15175154.
        View in: PubMed
      88. Abraham R, Weiss A. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol. 2004 Apr; 4(4):301-8. PMID: 15057788.
        View in: PubMed
      89. Zakaria S, Gomez TS, Savoy DN, McAdam S, Turner M, Abraham R, Billadeau DD. Differential regulation of TCR-mediated gene transcription by Vav family members. J Exp Med. 2004 Feb 2; 199(3):429-34. PMID: 14757747.
        View in: PubMed
      90. Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean NM, Abraham R, Wang XF. Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev. 2004 Feb 1; 18(3):249-54. PMID: 14871926.
        View in: PubMed
      91. Chiang GG, Abraham R. Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family. Methods Mol Biol. 2004; 281:125-41. PMID: 15220525.
        View in: PubMed
      92. Abraham R. mTOR as a positive regulator of tumor cell responses to hypoxia. Curr Top Microbiol Immunol. 2004; 279:299-319. PMID: 14560965.
        View in: PubMed
      93. Edinger AL, Linardic CM, Chiang GG, Thompson CB, Abraham R. Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Res. 2003 Dec 1; 63(23):8451-60. PMID: 14679009.
        View in: PubMed
      94. Zeng R, Cannon JL, Abraham R, Way M, Billadeau DD, Bubeck-Wardenberg J, Burkhardt JK. SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol. 2003 Aug 1; 171(3):1360-8. PMID: 12874226.
        View in: PubMed
      95. Abraham R. Rap1 redux. Nat Immunol. 2003 Aug; 4(8):725-7. PMID: 12888790.
        View in: PubMed
      96. Abraham R. Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase. Bioessays. 2003 Jul; 25(7):627-30. PMID: 12815717.
        View in: PubMed
      97. Fang Y, Linardic CM, Richardson DA, Cai W, Behforouz M, Abraham R. Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin. Mol Cancer Ther. 2003 Jun; 2(6):517-26. PMID: 12813130.
        View in: PubMed
      98. Plattner R, Irvin BJ, Guo S, Blackburn K, Kazlauskas A, Abraham R, York JD, Pendergast AM. A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nat Cell Biol. 2003 Apr; 5(4):309-19. PMID: 12652307.
        View in: PubMed
      99. Piccolella E, Spadaro F, Ramoni C, Marinari B, Costanzo A, Levrero M, Thomson L, Abraham R, Tuosto L. Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement. J Immunol. 2003 Mar 15; 170(6):2895-903. PMID: 12626540.
        View in: PubMed
      100. Abraham R. Checkpoint signalling: focusing on 53BP1. Nat Cell Biol. 2002 Dec; 4(12):E277-9. PMID: 12461529.
        View in: PubMed
      101. Sasahara Y, Rachid R, Byrne MJ, de la Fuente MA, Abraham R, Ramesh N, Geha RS. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell. 2002 Dec; 10(6):1269-81. PMID: 12504004.
        View in: PubMed
      102. Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, Abraham R, Schoenberger SP, Mustelin T. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol. 2003 Jan; 4(1):44-8. PMID: 12447358.
        View in: PubMed
      103. McMahon LP, Choi KM, Lin TA, Abraham R, Lawrence JC. The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin. Mol Cell Biol. 2002 Nov; 22(21):7428-38. PMID: 12370290.
        View in: PubMed
      104. Abraham R. Identification of TOR signaling complexes: more TORC for the cell growth engine. Cell. 2002 Oct 4; 111(1):9-12. PMID: 12372295.
        View in: PubMed
      105. Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham R. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002 Oct; 22(20):7004-14. PMID: 12242281.
        View in: PubMed
      106. Okai M, Nieda M, Tazbirkova A, Horley D, Kikuchi A, Durrant S, Takahashi T, Boyd A, Abraham R, Yagita H, Juji T, Nicol A. Human peripheral blood Valpha24+ Vbeta11+ NKT cells expand following administration of alpha-galactosylceramide-pulsed dendritic cells. Vox Sang. 2002 Oct; 83(3):250-3. PMID: 12366768.
        View in: PubMed
      107. Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham R. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J. 2002 Sep 16; 21(18):4809-19. PMID: 12234921.
        View in: PubMed
      108. Hamad NM, Elconin JH, Karnoub AE, Bai W, Rich JN, Abraham R, Der CJ, Counter CM. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 2002 Aug 15; 16(16):2045-57. PMID: 12183360.
        View in: PubMed
      109. Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham R, Couture C, Mustelin T. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem. 2002 Jul 5; 277(27):24220-4. PMID: 11976341.
        View in: PubMed
      110. Villalba M, Bi K, Hu J, Altman Y, Bushway P, Reits E, Neefjes J, Baier G, Abraham R, Altman A. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol. 2002 Apr 15; 157(2):253-63. PMID: 11956228.
        View in: PubMed
      111. Mustelin T, Abraham R, Rudd CE, Alonso A, Merlo JJ. Protein tyrosine phosphorylation in T cell signaling. Front Biosci. 2002 Apr 1; 7:d918-69. PMID: 11897562.
        View in: PubMed
      112. Abraham R. Antigen receptors rap to integrin receptors. Nat Immunol. 2002 Mar; 3(3):212-3. PMID: 11875457.
        View in: PubMed
      113. Hammond EM, Denko NC, Dorie MJ, Abraham R, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol. 2002 Mar; 22(6):1834-43. PMID: 11865061.
        View in: PubMed
      114. Peng H, Kim DI, Sarkaria JN, Cho YS, Abraham R, Zalkow LH. Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases. Bioorg Med Chem. 2002 Jan; 10(1):167-74. PMID: 11738618.
        View in: PubMed
      115. Naumov YN, Bahjat KS, Gausling R, Abraham R, Exley MA, Koezuka Y, Balk SB, Strominger JL, Clare-Salzer M, Wilson SB. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13838-43. PMID: 11707602.
        View in: PubMed
      116. Abraham R. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 2001 Sep 1; 15(17):2177-96. PMID: 11544175.
        View in: PubMed
      117. Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham R, Wang XF. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature. 2001 Jun 21; 411(6840):969-74. PMID: 11418864.
        View in: PubMed
      118. Peng H, Xie W, Otterness DM, Cogswell JP, McConnell RT, Carter HL, Powis G, Abraham R, Zalkow LH. Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. J Med Chem. 2001 Mar 1; 44(5):834-48. PMID: 11262093.
        View in: PubMed
      119. Livolsi A, Busuttil V, Imbert V, Abraham R, Peyron JF. Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. Eur J Biochem. 2001 Mar; 268(5):1508-15. PMID: 11231305.
        View in: PubMed
      120. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham R. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000 Dec 1; 14(23):2989-3002. PMID: 11114888.
        View in: PubMed
      121. Irvin BJ, Williams BL, Nilson AE, Maynor HO, Abraham R. Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. Mol Cell Biol. 2000 Dec; 20(24):9149-61. PMID: 11094067.
        View in: PubMed
      122. Mothe-Satney I, Brunn GJ, McMahon LP, Capaldo CT, Abraham R, Lawrence JC. Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. J Biol Chem. 2000 Oct 27; 275(43):33836-43. PMID: 10942774.
        View in: PubMed
      123. Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham R. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000 Jul 1; 60(13):3504-13. PMID: 10910062.
        View in: PubMed
      124. Busby EC, Leistritz DF, Abraham R, Karnitz LM, Sarkaria JN. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res. 2000 Apr 15; 60(8):2108-12. PMID: 10786669.
        View in: PubMed
      125. Peng H, Xie W, Kim DI, Zalkow LH, Powis G, Otterness DM, Abraham R. Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase. Bioorg Med Chem. 2000 Feb; 8(2):299-306. PMID: 10722152.
        View in: PubMed
      126. Binstadt BA, Williams BL, Abraham R, Leibson PJ. Use of mutant Jurkat T cell lines to define human natural killer cell surface receptor signaling pathways. Methods Mol Biol. 2000; 121:297-304. PMID: 10818735.
        View in: PubMed
      127. Abraham R. Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways. Immunol Res. 2000; 22(2-3):95-117. PMID: 11339369.
        View in: PubMed
      128. Das P, Abraham R, David C. HLA transgenic mice as models of human autoimmune diseases. Rev Immunogenet. 2000; 2(1):105-14. PMID: 11324683.
        View in: PubMed
      129. Abraham R, Chen C, Tsang R, Simpson D, Murray C, Davidson M, Meharchand J, Sutton DM, Crump RM, Keating A, Stewart AK. Intensification of the stem cell transplant induction regimen results in increased treatment-related mortality without improved outcome in multiple myeloma. Bone Marrow Transplant. 1999 Dec; 24(12):1291-7. PMID: 10627637.
        View in: PubMed
      130. Reiter TA, Abraham R, Choi M, Rusnak F. Redox regulation of calcineurin in T-lymphocytes. J Biol Inorg Chem. 1999 Oct; 4(5):632-44. PMID: 10550693.
        View in: PubMed
      131. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham R. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 1999 Sep 1; 59(17):4375-82. PMID: 10485486.
        View in: PubMed
      132. Zhang W, Irvin BJ, Trible RP, Abraham R, Samelson LE. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int Immunol. 1999 Jun; 11(6):943-50. PMID: 10360968.
        View in: PubMed
      133. Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham R, Hoekstra MF, Aebersold R, Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999 Jun 1; 13(11):1422-37. PMID: 10364159.
        View in: PubMed
      134. Williams BL, Irvin BJ, Sutor SL, Chini CC, Yacyshyn E, Bubeck Wardenburg J, Dalton M, Chan AC, Abraham R. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation. EMBO J. 1999 Apr 1; 18(7):1832-44. PMID: 10202147.
        View in: PubMed
      135. Sutor SL, Vroman BT, Armstrong EA, Abraham R, Karnitz LM. A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf. J Biol Chem. 1999 Mar 12; 274(11):7002-10. PMID: 10066754.
        View in: PubMed
      136. Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Irvin BJ, Zhang W, Samelson LE, Abraham R, Leibson PJ. Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J Immunol. 1999 Mar 1; 162(5):2453-6. PMID: 10072481.
        View in: PubMed
      137. Hosoi H, Dilling MB, Shikata T, Liu LN, Shu L, Ashmun RA, Germain GS, Abraham R, Houghton PJ. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 1999 Feb 15; 59(4):886-94. PMID: 10029080.
        View in: PubMed
      138. Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C, Abraham R. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 1999 Jan 15; 13(2):152-7. PMID: 9925639.
        View in: PubMed
      139. Iiboshi Y, Papst PJ, Kawasome H, Hosoi H, Abraham R, Houghton PJ, Terada N. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem. 1999 Jan 8; 274(2):1092-9. PMID: 9873056.
        View in: PubMed
      140. Zhao Q, Williams BL, Abraham R, Weiss A. Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Mol Cell Biol. 1999 Jan; 19(1):948-56. PMID: 9858619.
        View in: PubMed
      141. Peng H, Zalkow LH, Abraham R, Powis G. Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel. J Med Chem. 1998 Nov 19; 41(24):4677-80. PMID: 9822537.
        View in: PubMed
      142. Hosoi H, Dilling MB, Liu LN, Danks MK, Shikata T, Sekulic A, Abraham R, Lawrence JC, Houghton PJ. Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol Pharmacol. 1998 Nov; 54(5):815-24. PMID: 9804616.
        View in: PubMed
      143. Binstadt BA, Billadeau DD, Jevremovic D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham R, Leibson PJ. SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem. 1998 Oct 16; 273(42):27518-23. PMID: 9765283.
        View in: PubMed
      144. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham R. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 1998 Oct 1; 58(19):4375-82. PMID: 9766667.
        View in: PubMed
      145. Abraham R. Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr Opin Immunol. 1998 Jun; 10(3):330-6. PMID: 9638370.
        View in: PubMed
      146. Singh N, Bhatia S, Abraham R, Basu SK, George A, Bal V, Rath S. Modulation of T cell cytokine profiles and peptide-MHC complex availability in vivo by delivery to scavenger receptors via antigen maleylation. J Immunol. 1998 May 15; 160(10):4869-80. PMID: 9590234.
        View in: PubMed
      147. Kennedy AP, Sekulic A, Irvin BJ, Nilson AE, Dilworth SM, Abraham R. Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signaling pathways. J Biol Chem. 1998 May 8; 273(19):11505-13. PMID: 9565564.
        View in: PubMed
      148. Kato M, Abraham R, Okada S, Kita H. Ligation of the beta2 integrin triggers activation and degranulation of human eosinophils. Am J Respir Cell Mol Biol. 1998 May; 18(5):675-86. PMID: 9569238.
        View in: PubMed
      149. Williams BL, Schreiber KL, Zhang W, Wange RL, Samelson LE, Leibson PJ, Abraham R. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol. 1998 Mar; 18(3):1388-99. PMID: 9488454.
        View in: PubMed
      150. Petricoin EF, Ito S, Williams BL, Audet S, Stancato LF, Gamero A, Clouse K, Grimley P, Weiss A, Beeler J, Finbloom DS, Shores EW, Abraham R, Larner AC. Antiproliferative action of interferon-alpha requires components of T-cell-receptor signalling. Nature. 1997 Dec 11; 390(6660):629-32. PMID: 9403695.
        View in: PubMed
      151. Sloan-Lancaster J, Zhang W, Presley J, Williams BL, Abraham R, Lippincott-Schwartz J, Samelson LE. Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. J Exp Med. 1997 Nov 17; 186(10):1713-24. PMID: 9362531.
        View in: PubMed
      152. Lawrence JC, Abraham R. PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem Sci. 1997 Sep; 22(9):345-9. PMID: 9301335.
        View in: PubMed
      153. Eischen CM, Williams BL, Zhang W, Samelson LE, Lynch DH, Abraham R, Leibson PJ. ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. J Immunol. 1997 Aug 1; 159(3):1135-9. PMID: 9233606.
        View in: PubMed
      154. Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ, Lawrence JC, Abraham R. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. 1997 Jul 4; 277(5322):99-101. PMID: 9204908.
        View in: PubMed
      155. Powis G, Gallegos A, Abraham R, Ashendel CL, Zalkow LH, Dorr R, Dvorakova K, Salmon S, Harrison S, Worzalla J. Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues. Cancer Chemother Pharmacol. 1997; 41(1):22-8. PMID: 9443610.
        View in: PubMed
      156. Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham R, Leibson PJ. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity. 1996 Dec; 5(6):629-38. PMID: 8986721.
        View in: PubMed
      157. Lim KK, Su WP, Schroeter AL, Sabers CJ, Abraham R, Pittelkow MR. Cyclosporine in the treatment of dermatologic disease: an update. Mayo Clin Proc. 1996 Dec; 71(12):1182-91. PMID: 8945493.
        View in: PubMed
      158. Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC, Abraham R. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 1996 Oct 1; 15(19):5256-67. PMID: 8895571.
        View in: PubMed
      159. Stec B, Abraham R, Giroux E, Kantrowitz ER. Crystal structures of the active site mutant (Arg-243-->Ala) in the T and R allosteric states of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli. Protein Sci. 1996 Aug; 5(8):1541-53. PMID: 8844845.
        View in: PubMed
      160. Abraham R. Phosphatidylinositol 3-kinase related kinases. Curr Opin Immunol. 1996 Jun; 8(3):412-8. PMID: 8793996.
        View in: PubMed
      161. Abraham R, Wiederrecht GJ. Immunopharmacology of rapamycin. Annu Rev Immunol. 1996; 14:483-510. PMID: 8717522.
        View in: PubMed
      162. Karnitz LM, Abraham R. Interleukin-2 receptor signaling mechanisms. Adv Immunol. 1996; 61:147-99. PMID: 8834496.
        View in: PubMed
      163. Evans GA, Goldsmith MA, Johnston JA, Xu W, Weiler SR, Erwin R, Howard OM, Abraham R, O'Shea JJ, Greene WC. Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem. 1995 Dec 1; 270(48):28858-63. PMID: 7499411.
        View in: PubMed
      164. Lam E, Martin MM, Timerman AP, Sabers C, Fleischer S, Lukas T, Abraham R, O'Keefe SJ, O'Neill EA, Wiederrecht GJ. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. J Biol Chem. 1995 Nov 3; 270(44):26511-22. PMID: 7592869.
        View in: PubMed
      165. Bonnema JD, Karnitz LM, Schoon RA, Abraham R, Leibson PJ. Fc receptor stimulation of PI 3-kinase in NK cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. Ann N Y Acad Sci. 1995 Sep 7; 766:209-13. PMID: 7486660.
        View in: PubMed
      166. Ting AT, Dick CJ, Schoon RA, Karnitz LM, Abraham R, Leibson PJ. Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells. J Biol Chem. 1995 Jul 7; 270(27):16415-21. PMID: 7541798.
        View in: PubMed
      167. Kato M, Abraham R, Kita H. Tyrosine phosphorylation is required for eosinophil degranulation induced by immobilized immunoglobulins. J Immunol. 1995 Jul 1; 155(1):357-66. PMID: 7602111.
        View in: PubMed
      168. Karnitz LM, Abraham R. Cytokine receptor signaling mechanisms. Curr Opin Immunol. 1995 Jun; 7(3):320-6. PMID: 7546395.
        View in: PubMed
      169. Frew T, Powis G, Berggren M, Gallegos A, Abraham R, Ashendel CL, Zalkow LH, Hudson C, Gruszecka-Kowalik E, Burgess EM. Novel quinone antiproliferative inhibitors of phosphatidylinositol-3-kinase. Anticancer Drug Des. 1995 Jun; 10(4):347-59. PMID: 7786399.
        View in: PubMed
      170. Karnitz LM, Burns LA, Sutor SL, Blenis J, Abraham R. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol Cell Biol. 1995 Jun; 15(6):3049-57. PMID: 7760801.
        View in: PubMed
      171. Brunn GJ, Falls EL, Nilson AE, Abraham R. Protein-tyrosine kinase-dependent activation of STAT transcription factors in interleukin-2- or interleukin-4-stimulated T lymphocytes. J Biol Chem. 1995 May 12; 270(19):11628-35. PMID: 7744803.
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      172. Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, Abraham R. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 1995 Jan 13; 270(2):815-22. PMID: 7822316.
        View in: PubMed
      173. Abraham R, Acquarone M, Andersen A, Asensi A, Bellé R, Berger F, Bergounioux C, Brunn G, Buquet-Fagot C, Fagot D. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol Cell. 1995; 83(2-3):105-20. PMID: 7549905.
        View in: PubMed
      174. Abraham R, Singh N, Mukhopadhyay A, Basu SK, Bal V, Rath S. Modulation of immunogenicity and antigenicity of proteins by maleylation to target scavenger receptors on macrophages. J Immunol. 1995 Jan 1; 154(1):1-8. PMID: 7527810.
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      175. Powis G, Berggren M, Gallegos A, Frew T, Hill S, Kozikowski A, Bonjouklian R, Zalkow L, Abraham R, Ashendel C. Advances with phospholipid signalling as a target for anticancer drug development. Acta Biochim Pol. 1995; 42(4):395-403. PMID: 8852330.
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      176. Wiederrecht GJ, Sabers CJ, Brunn GJ, Martin MM, Dumont FJ, Abraham R. Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res. 1995; 1:53-71. PMID: 9552353.
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      177. Kita H, Kato M, Gleich GJ, Abraham R. Tyrosine phosphorylation and inositol phosphate production: are early events in human eosinophil activation stimulated by immobilized secretory IgA and IgG? J Allergy Clin Immunol. 1994 Dec; 94(6 Pt 2):1272-81. PMID: 7798568.
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      178. Frew T, Powis G, Berggren M, Abraham R, Ashendel CL, Zalkow LH, Hudson C, Qazia S, Gruszecka-Kowalik E, Merriman R. A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors. Anticancer Res. 1994 Nov-Dec; 14(6B):2425-8. PMID: 7872663.
        View in: PubMed
      179. Bonnema JD, Karnitz LM, Schoon RA, Abraham R, Leibson PJ. Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. J Exp Med. 1994 Oct 1; 180(4):1427-35. PMID: 7931075.
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      180. Hill SR, Bonjouklian R, Powis G, Abraham R, Ashendel CL, Zalkow LH. A multisample assay for inhibitors of phosphatidylinositol phospholipase C: identification of naturally occurring peptide inhibitors with antiproliferative activity. Anticancer Drug Des. 1994 Aug; 9(4):353-61. PMID: 7916901.
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      181. Karnitz LM, Sutor SL, Abraham R. The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line. J Exp Med. 1994 Jun 1; 179(6):1799-808. PMID: 7515100.
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      182. Powis G, Bonjouklian R, Berggren MM, Gallegos A, Abraham R, Ashendel C, Zalkow L, Matter WF, Dodge J, Grindey G. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 1994 May 1; 54(9):2419-23. PMID: 8162590.
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      183. Bonnema JD, Rivlin KA, Ting AT, Schoon RA, Abraham R, Leibson PJ. Cytokine-enhanced NK cell-mediated cytotoxicity. Positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J Immunol. 1994 Mar 1; 152(5):2098-104. PMID: 7907631.
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      184. Powis G, Gallegos A, Abraham R, Ashendel CL, Zalkow LH, Grindey GB, Bonjouklian R. Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues. Cancer Chemother Pharmacol. 1994; 34(4):344-50. PMID: 8033301.
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      185. Abraham R, Karnitz LM, Burns LA, Brunn GJ. Proximal signals and the control of S-phase entry in interleukin-2-stimulated T lymphocytes. Adv Exp Med Biol. 1994; 365:197-210. PMID: 7887304.
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      186. Morice WG, Wiederrecht G, Brunn GJ, Siekierka JJ, Abraham R. Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes. J Biol Chem. 1993 Oct 25; 268(30):22737-45. PMID: 8226784.
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      187. Burns LA, Karnitz LM, Sutor SL, Abraham R. Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes. J Biol Chem. 1993 Aug 25; 268(24):17659-61. PMID: 7688728.
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      188. Lutz MP, Sutor SL, Abraham R, Miller LJ. A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell. J Biol Chem. 1993 May 25; 268(15):11119-24. PMID: 7684371.
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      189. Berggren MM, Burns LA, Abraham R, Powis G. Inhibition of protein tyrosine phosphatase by the antitumor agent gallium nitrate. Cancer Res. 1993 Apr 15; 53(8):1862-6. PMID: 8467506.
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      190. Secrist JP, Burns LA, Karnitz L, Koretzky GA, Abraham R. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J Biol Chem. 1993 Mar 15; 268(8):5886-93. PMID: 8383678.
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      191. Morice WG, Brunn GJ, Wiederrecht G, Siekierka JJ, Abraham R. Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes. J Biol Chem. 1993 Feb 15; 268(5):3734-8. PMID: 8429048.
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      192. Ting AT, Karnitz LM, Schoon RA, Abraham R, Leibson PJ. Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells. J Exp Med. 1992 Dec 1; 176(6):1751-5. PMID: 1281218.
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      193. Ting AT, Schoon RA, Abraham R, Leibson PJ. Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis. J Biol Chem. 1992 Nov 25; 267(33):23957-62. PMID: 1429733.
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      194. Einspahr KJ, Abraham R, Dick CJ, Leibson PJ. Interleukin-2 signal transduction in human NK cells: multisite phosphorylation and activation of the tyrosine kinase p56lck. J Leukoc Biol. 1992 Nov; 52(5):565-71. PMID: 1385559.
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      195. Karnitz L, Sutor SL, Torigoe T, Reed JC, Bell MP, McKean DJ, Leibson PJ, Abraham R. Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol Cell Biol. 1992 Oct; 12(10):4521-30. PMID: 1406641.
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      196. Abraham R, Karnitz LM, Secrist JP, Leibson PJ. Signal transduction through the T-cell antigen receptor. Trends Biochem Sci. 1992 Oct; 17(10):434-8. PMID: 1455512.
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      197. Kreofsky T, Schlager JW, Vuk-Pavlovic Z, Abraham R, Rohrbach MS. Condensed tannin promotes the release of arachidonic acid from rabbit resident alveolar macrophages. Am J Respir Cell Mol Biol. 1992 Aug; 7(2):172-81. PMID: 1497906.
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      198. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham R. Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation. J Immunol. 1991 Nov 15; 147(10):3466-73. PMID: 1719078.
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      199. Ting AT, Einspahr KJ, Abraham R, Leibson PJ. Fc gamma receptor signal transduction in natural killer cells. Coupling to phospholipase C via a G protein-independent, but tyrosine kinase-dependent pathway. J Immunol. 1991 Nov 1; 147(9):3122-7. PMID: 1833464.
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      200. Augustine JA, Sutor SL, Abraham R. Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes. Mol Cell Biol. 1991 Sep; 11(9):4431-40. PMID: 1652056.
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      201. Einspahr KJ, Abraham R, Binstadt BA, Uehara Y, Leibson PJ. Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6279-83. PMID: 2068107.
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      202. Secrist JP, Karnitz L, Abraham R. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1. J Biol Chem. 1991 Jul 5; 266(19):12135-9. PMID: 2061301.
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      203. Voss LM, Abraham R, Rhodes KH, Schoon RA, Leibson PJ. Defective T-lymphocyte signal transduction and function in leukocyte adhesion deficiency. J Clin Immunol. 1991 Jul; 11(4):175-83. PMID: 1918265.
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      204. Augustine JA, Secrist JP, Daniels JK, Leibson PJ, Abraham R. Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism. J Immunol. 1991 May 1; 146(9):2889-97. PMID: 1707924.
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      205. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham R. Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate. J Immunol. 1991 Apr 15; 146(8):2712-8. PMID: 1707917.
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      206. Secrist JP, Sehgal I, Powis G, Abraham R. Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine. J Biol Chem. 1990 Nov 25; 265(33):20394-400. PMID: 2173705.
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      207. Leibson PJ, Midthun DE, Windebank KP, Abraham R. Transmembrane signaling during natural killer cell-mediated cytotoxicity. Regulation by protein kinase C activation. J Immunol. 1990 Sep 1; 145(5):1498-504. PMID: 2166762.
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      208. Kanba S, Kanba KS, McKinney M, Pfenning M, Abraham R, Nomura S, Enloes L, Mackey S, Richelson E. Desensitization of muscarinic M1 receptors of murine neuroblastoma cells (clone N1E-115) without receptor down-regulation and protein kinase C activity. Biochem Pharmacol. 1990 Sep 1; 40(5):1005-14. PMID: 2167677.
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      209. Einspahr KJ, Abraham R, Dick CJ, Leibson PJ. Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells. J Immunol. 1990 Sep 1; 145(5):1490-7. PMID: 1696599.
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      210. Augustine JA, Schlager JW, Abraham R. Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells. Biochim Biophys Acta. 1990 May 2; 1052(2):313-22. PMID: 2334739.
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      211. Ruegemer JJ, Ho SN, Augustine JA, Schlager JW, Bell MP, McKean DJ, Abraham R. Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression. J Immunol. 1990 Mar 1; 144(5):1767-76. PMID: 2407783.
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      212. Olsen R, Melder D, Seewald M, Abraham R, Powis G. Staurosporine inhibition of intracellular free Ca2+ transients in mitogen-stimulated Swiss 3T3 fibroblasts. Biochem Pharmacol. 1990 Mar 1; 39(5):968-72. PMID: 2310422.
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      213. Oakes SG, Schlager JJ, Santone KS, Abraham R, Powis G. Doxorubicin blocks the increase in intracellular Ca++, part of a second messenger system in N1E-115 murine neuroblastoma cells. J Pharmacol Exp Ther. 1990 Mar; 252(3):979-83. PMID: 2319480.
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      214. Hooper WC, Abraham R, Ashendel CL, Woloschak GE. Differential responsiveness to phorbol esters correlates with differential expression of protein kinase C in KG-1 and KG-1a human myeloid leukemia cells. Biochim Biophys Acta. 1989 Sep 4; 1013(1):47-54. PMID: 2790038.
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      215. Pittelkow MR, Lindquist PB, Abraham R, Graves-Deal R, Derynck R, Coffey RJ. Induction of transforming growth factor-alpha expression in human keratinocytes by phorbol esters. J Biol Chem. 1989 Mar 25; 264(9):5164-71. PMID: 2925687.
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      216. Leibson PJ, Windebank KP, Barna TJ, Abraham R. Signal transduction mechanisms in human natural killer cells mediating antitumor immunity. Haematol Blood Transfus. 1989; 32:281-3. PMID: 2560445.
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      217. Olsen R, Santone K, Melder D, Oakes SG, Abraham R, Powis G. An increase in intracellular free Ca2+ associated with serum-free growth stimulation of Swiss 3T3 fibroblasts by epidermal growth factor in the presence of bradykinin. J Biol Chem. 1988 Dec 5; 263(34):18030-5. PMID: 3263965.
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      218. Abraham R, Ho SN, Barna TJ, Rusovick KM, McKean DJ. Inhibition of T-cell antigen receptor-mediated transmembrane signaling by protein kinase C activation. Mol Cell Biol. 1988 Dec; 8(12):5448-58. PMID: 2977423.
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      219. Windebank KP, Abraham R, Powis G, Olsen RA, Barna TJ, Leibson PJ. Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP. J Immunol. 1988 Dec 1; 141(11):3951-7. PMID: 2846696.
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      220. Ho SN, Abraham R, Nilson A, Handwerger BS, McKean DJ. Interleukin 1-mediated activation of interleukin 4 (IL 4)-producing T lymphocytes. Proliferation by IL 4-dependent and IL 4-independent mechanisms. J Immunol. 1987 Sep 1; 139(5):1532-40. PMID: 3114369.
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      221. Abraham R, Ho SN, Barna TJ, McKean DJ. Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism. J Biol Chem. 1987 Feb 25; 262(6):2719-28. PMID: 3029093.
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      222. Abraham R, McKinney MM, Forray C, Shipley GD, Handwerger BS. Stimulation of arachidonic acid release and eicosanoid biosynthesis in an interleukin 2-dependent T cell line. J Immunopharmacol. 1986; 8(2):165-204. PMID: 3088127.
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      223. Abraham R, Benson LM, Jardine I. Influence of hepatic oxidative metabolism on the immunosuppressive activities of 6-thiopurines. J Pharmacol Exp Ther. 1985 Sep; 234(3):670-6. PMID: 3162017.
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      224. Abraham R, Benson LM, Jardine I. Synthesis and pH-dependent stability of purine-6-sulfenic acid, a putative reactive metabolite of 6-thiopurine. J Med Chem. 1983 Oct; 26(10):1523-6. PMID: 6684689.
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      225. Abraham R, Wienberg J, Schnedl W. Analysis of heterochromatin and identification of mitotic chromosomes in Drosophila virilis by GC- and AT-specific fluorochromes. Mikroskopie. 1983 Feb; 40(1-2):4-8. PMID: 6856092.
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      226. O'Keefe SJ, Abraham R, El-Zayadi A, Marshall W, Davis M, Williams R. Increased plasma tyrosine concentrations in patients with cirrhosis and fulminant hepatic failure associated with increased plasma tyrosine flux and reduced hepatic oxidation capacity. Gastroenterology. 1981 Dec; 81(6):1017-24. PMID: 7286580.
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      227. Brunelle CW, Bochenek WJ, Abraham R, Kim DN, Rodgers JB. Effect of hydrophobic detergent on lipid absorption in the rat and on lipid and sterol balance in the swine. Dig Dis Sci. 1979 Sep; 24(9):718-25. PMID: 487926.
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      228. Basten A, Miller JF, Warner NL, Abraham R, Chia E, Gamble J. A subpopulation of T cells bearing Fc receptors. J Immunol. 1975 Oct; 115(4):1159-65. PMID: 1100723.
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      229. Basten A, Miller JF, Abraham R. Relationship between Fc receptors, antigen-binding sites on T and B cells, and H-2 complex-associated determinants. J Exp Med. 1975 Mar 1; 141(3):547-60. PMID: 46915.
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