Robert Abraham

Title(s)Adjunct Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Roles of ATM and ATR Kinases in DNA Damage Responses
    NIH/NCI R01CA097950Mar 1, 2002 - Feb 28, 2007
    Role: Co-Principal Investigator
    Cellular Pharmacology of Rapamycin
    NIH/NCI R01CA076193Dec 8, 1997 - Feb 28, 2009
    Role: Co-Principal Investigator
    SIGNAL TRANSDUCTION FROM THE T CELL ANTIGEN RECEPTOR
    NIH/NIGMS R01GM047286May 1, 1992 - Jul 31, 2005
    Role: Principal Investigator
    Cancer Center Support Grant (CCSG)
    NIH/NCI P30CA030199Jul 1, 1981 - Apr 30, 2020
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Formation of a low-mass galaxy from star clusters in a 600-million-year-old Universe. Nature. 2024 Dec; 636(8042):332-336. Mowla L, Iyer K, Asada Y, Desprez G, Tan VYY, Martis N, Sarrouh G, Strait V, Abraham R, Bradac M, Brammer G, Muzzin A, Pacifici C, Ravindranath S, Sawicki M, Willott C, Estrada-Carpenter V, Jahan N, Noirot G, Matharu J, Rihtaršic G, Zabl J. PMID: 39663487; PMCID: PMC11634762.
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    2. Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature. 2024 Jul; 631(8021):E12. Baltgalvis KA, Lamb KN, Symons KT, Wu CC, Hoffman MA, Snead AN, Song X, Glaza T, Kikuchi S, Green JC, Rogness DC, Lam B, Rodriguez-Aguirre ME, Woody DR, Eissler CL, Rodiles S, Negron SM, Bernard SM, Tran E, Pollock J, Tabatabaei A, Contreras V, Williams HN, Pastuszka MK, Sigler JJ, Pettazzoni P, Rudolph MG, Classen M, Brugger D, Claiborne C, Plancher JM, Cuartas I, Seoane J, Burgess LE, Abraham RT, Weinstein DS, Simon GM, Patricelli MP, Kinsella TM. PMID: 38961306.
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    3. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature. 2024 May; 629(8011):435-442. Baltgalvis KA, Lamb KN, Symons KT, Wu CC, Hoffman MA, Snead AN, Song X, Glaza T, Kikuchi S, Green JC, Rogness DC, Lam B, Rodriguez-Aguirre ME, Woody DR, Eissler CL, Rodiles S, Negron SM, Bernard SM, Tran E, Pollock J, Tabatabaei A, Contreras V, Williams HN, Pastuszka MK, Sigler JJ, Pettazzoni P, Rudolph MG, Classen M, Brugger D, Claiborne C, Plancher JM, Cuartas I, Seoane J, Burgess LE, Abraham RT, Weinstein DS, Simon GM, Patricelli MP, Kinsella TM. PMID: 38658751.
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    4. A trail of dark-matter-free galaxies from a bullet-dwarf collision. Nature. 2022 05; 605(7910):435-439. van Dokkum P, Shen Z, Keim MA, Trujillo-Gomez S, Danieli S, Dutta Chowdhury D, Abraham R, Conroy C, Kruijssen JMD, Nagai D, Romanowsky A. PMID: 35585344; PMCID: PMC9117144.
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    5. Direct control of CAR T cells through small molecule-regulated antibodies. Nat Commun. 2021 01 29; 12(1):710. Park S, Pascua E, Lindquist KC, Kimberlin C, Deng X, Mak YSL, Melton Z, Johnson TO, Lin R, Boldajipour B, Abraham RT, Pons J, Sasu BJ, Van Blarcom TJ, Chaparro-Riggers J. PMID: 33514714; PMCID: PMC7846603.
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    6. Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells. Cell Cycle. 2021 01; 20(1):65-80. Maskey RS, Wang F, Lehman E, Wang Y, Emmanuel N, Zhong W, Jin G, Abraham RT, Arndt KT, Myers JS, Mazurek A. PMID: 33356791; PMCID: PMC7849761.
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    7. Anti-tumor immunity influences cancer cell reliance upon ATG7. Oncoimmunology. 2020 08 23; 9(1):1800162. Arensman MD, Yang XS, Zhong W, Bisulco S, Upeslacis E, Rosfjord EC, Deng S, Abraham RT, Eng CH. PMID: 32923161; PMCID: PMC7458662.
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    8. A sugary input to leucine sensing. Science. 2020 01 10; 367(6474):146-147. Lehman E, Abraham RT. PMID: 31919209.
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    9. Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9533-9542. Arensman MD, Yang XS, Leahy DM, Toral-Barza L, Mileski M, Rosfjord EC, Wang F, Deng S, Myers JS, Abraham RT, Eng CH. PMID: 31019077; PMCID: PMC6511047.
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    10. A galaxy lacking dark matter. Nature. 2018 03 28; 555(7698):629-632. van Dokkum P, Danieli S, Cohen Y, Merritt A, Romanowsky AJ, Abraham R, Brodie J, Conroy C, Lokhorst D, Mowla L, O'Sullivan E, Zhang J. PMID: 29595770.
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    11. The PI3K Pathway in Human Disease. Cell. 2017 Aug 10; 170(4):605-635. Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. PMID: 28802037; PMCID: PMC5726441.
      View in: PubMed   Mentions: 1106     Fields:    Translation:HumansAnimalsCells
    12. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 06 27; 19(13):2665-2680. Emmanuel N, Ragunathan S, Shan Q, Wang F, Giannakou A, Huser N, Jin G, Myers J, Abraham RT, Unsal-Kacmaz K. PMID: 28658616.
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    13. The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration. Mol Cell. 2017 Mar 16; 65(6):959-960. Ihle NT, Abraham RT. PMID: 28306509.
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    14. Lysosomal adaptation: How cells respond to lysosomotropic compounds. PLoS One. 2017; 12(3):e0173771. Lu S, Sung T, Lin N, Abraham RT, Jessen BA. PMID: 28301521; PMCID: PMC5354416.
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    15. 4E-BP2 hardwires lymphocytes for rapamycin sensitivity. Sci Signal. 2016 05 31; 9(430):fs10. Abraham RT. PMID: 27245610.
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    16. Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation. Cell Metab. 2016 Mar 08; 23(3):397-8. Abraham RT. PMID: 26959180.
      View in: PubMed   Mentions: 1     Fields:    
    17. Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):182-7. Eng CH, Wang Z, Tkach D, Toral-Barza L, Ugwonali S, Liu S, Fitzgerald SL, George E, Frias E, Cochran N, De Jesus R, McAllister G, Hoffman GR, Bray K, Lemon L, Lucas J, Fantin VR, Abraham RT, Murphy LO, Nyfeler B. PMID: 26677873; PMCID: PMC4711870.
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    18. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 01; 21(13):2905-10. VanArsdale T, Boshoff C, Arndt KT, Abraham RT. PMID: 25941111.
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    19. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene. 2015 Nov 05; 34(45):5662-76. Strohecker AM, Joshi S, Possemato R, Abraham RT, Sabatini DM, White E. PMID: 25772235; PMCID: PMC4573377.
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    20. Cell biology. Making sense of amino acid sensing. Science. 2015 Jan 09; 347(6218):128-9. Abraham RT. PMID: 25574008.
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    21. Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion. Nat Commun. 2014 Sep 25; 5:4900. Shanware NP, Bray K, Eng CH, Wang F, Follettie M, Myers J, Fantin VR, Abraham RT. PMID: 25254627; PMCID: PMC4200525.
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    22. Too little mTORC1 activity injures the liver. Cell Metab. 2014 Jul 01; 20(1):4-6. Abraham RT. PMID: 24988455.
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    23. MTOR mutations in the crosshairs of targeted therapy. Cancer Discov. 2014 May; 4(5):513-5. Rejto PA, Abraham RT. PMID: 24795009.
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    24. Self-eating limits EGFR-dependent tumor growth. Cell. 2013 Sep 12; 154(6):1184-6. Fantin VR, Abraham RT. PMID: 24034240.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    25. The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics. Nat Prod Rep. 2013 May; 30(5):625-39. Gerber HP, Koehn FE, Abraham RT. PMID: 23525375.
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    26. The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease. Annu Rev Pharmacol Toxicol. 2013; 53:89-106. Shanware NP, Bray K, Abraham RT. PMID: 23294306.
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    27. Chemokine to the rescue: interleukin-8 mediates resistance to PI3K-pathway-targeted therapy in breast cancer. Cancer Cell. 2012 Dec 11; 22(6):703-5. Abraham RT. PMID: 23238010.
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    28. Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells. Mol Cancer Ther. 2013 Jan; 12(1):38-47. Sapra P, Damelin M, Dijoseph J, Marquette K, Geles KG, Golas J, Dougher M, Narayanan B, Giannakou A, Khandke K, Dushin R, Ernstoff E, Lucas J, Leal M, Hu G, O'Donnell CJ, Tchistiakova L, Abraham RT, Gerber HP. PMID: 23223830.
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    29. Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies. Pigment Cell Melanoma Res. 2012 Nov; 25(6):819-31. Bagrodia S, Smeal T, Abraham RT. PMID: 22883054.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    30. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, et al. PMID: 22966490; PMCID: PMC3404883.
      View in: PubMed   Mentions: 1819     Fields:    Translation:HumansAnimals
    31. Serine biosynthesis: fuel for the melanoma cell growth engine. Pigment Cell Melanoma Res. 2011 Oct; 24(5):875-7. Dann SG, Abraham RT. PMID: 22081811.
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    32. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol. 2011 Nov; 31(22):4417-29. Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, Ohno S, Yamashita A, Abraham RT, Gueven N, Lavin MF. PMID: 21911475; PMCID: PMC3209244.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    33. Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian target of rapamycin inhibitor, temsirolimus, in a preclinical mammary carcinoma OncoMouse model: a translational medicine study in support for early clinical development. J Pharmacol Exp Ther. 2011 Nov; 339(2):421-9. Wang X, Zhan Y, Zhao L, Alvarez J, Chaudhary I, Zhou BB, Abraham RT, Feuerstein GZ. PMID: 21835932.
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    34. The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming. Oncogene. 2011 Nov 24; 30(47):4687-96. Eng CH, Abraham RT. PMID: 21666712.
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    35. Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells. Cancer Res. 2011 Jun 15; 71(12):4236-46. Damelin M, Geles KG, Follettie MT, Yuan P, Baxter M, Golas J, DiJoseph JF, Karnoub M, Huang S, Diesl V, Behrens C, Choe SE, Rios C, Gruzas J, Sridharan L, Dougher M, Kunz A, Hamann PR, Evans D, Armellino D, Khandke K, Marquette K, Tchistiakova L, Boghaert ER, Abraham RT, Wistuba II, Zhou BB. PMID: 21540235.
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    36. Glutamine: pleiotropic roles in tumor growth and stress resistance. J Mol Med (Berl). 2011 Mar; 89(3):229-36. Shanware NP, Mullen AR, DeBerardinis RJ, Abraham RT. PMID: 21301794.
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    37. Glutaminolysis yields a metabolic by-product that stimulates autophagy. Autophagy. 2010 Oct; 6(7):968-70. Eng CH, Abraham RT. PMID: 20724823; PMCID: PMC3039742.
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    38. A metabolic (re-)balancing act. Mol Cell. 2010 May 28; 38(4):481-2. Abraham RT, Eng CH. PMID: 20513422.
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    39. Lysosomal Rag-ulation of mTOR complex 1 activity. Cell Metab. 2010 May 05; 11(5):341-2. Abraham RT. PMID: 20444413.
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    40. Cancer and inflammation: promise for biologic therapy. J Immunother. 2010 May; 33(4):335-51. Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT. PMID: 20386472; PMCID: PMC2941912.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimals
    41. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal. 2010 Apr 27; 3(119):ra31. Eng CH, Yu K, Lucas J, White E, Abraham RT. PMID: 20424262.
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    42. Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor. J Med Chem. 2010 Mar 25; 53(6):2636-45. Venkatesan AM, Dehnhardt CM, Delos Santos E, Chen Z, Dos Santos O, Ayral-Kaloustian S, Khafizova G, Brooijmans N, Mallon R, Hollander I, Feldberg L, Lucas J, Yu K, Gibbons J, Abraham RT, Chaudhary I, Mansour TS. PMID: 20166697.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    43. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem. 2010 May 28; 285(22):16562-71. Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang TH, Cordeiro-Stone M, Kaufmann WK, Abraham RT, Sancar A, Unsal-Kaçmaz K. PMID: 20233725; PMCID: PMC2878033.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    44. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res. 2010 Jan 15; 70(2):621-31. Yu K, Shi C, Toral-Barza L, Lucas J, Shor B, Kim JE, Zhang WG, Mahoney R, Gaydos C, Tardio L, Kim SK, Conant R, Curran K, Kaplan J, Verheijen J, Ayral-Kaloustian S, Mansour TS, Abraham RT, Zask A, Gibbons JJ. PMID: 20068177.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimals
    45. Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle. 2009 Dec; 8(23):3831-7. Shor B, Gibbons JJ, Abraham RT, Yu K. PMID: 19901542.
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    46. Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol. 2009 Dec; 36 Suppl 3:S3-S17. Gibbons JJ, Abraham RT, Yu K. PMID: 19963098.
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    47. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell. 2009 Aug 28; 35(4):442-53. Zhang YW, Brognard J, Coughlin C, You Z, Dolled-Filhart M, Aslanian A, Manning G, Abraham RT, Hunter T. PMID: 19716789; PMCID: PMC2736145.
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    48. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27; 52(16):5013-6. Zask A, Verheijen JC, Curran K, Kaplan J, Richard DJ, Nowak P, Malwitz DJ, Brooijmans N, Bard J, Svenson K, Lucas J, Toral-Barza L, Zhang WG, Hollander I, Gibbons JJ, Abraham RT, Ayral-Kaloustian S, Mansour TS, Yu K. PMID: 19645448.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    49. GOLPH3 links the Golgi network to mTOR signaling and human cancer. Pigment Cell Melanoma Res. 2009 Aug; 22(4):378-9. Abraham RT. PMID: 19624311.
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    50. Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival. Mol Biol Cell. 2009 Sep; 20(17):3953-64. Lau E, Chiang GG, Abraham RT, Jiang W. PMID: 19587119; PMCID: PMC2735493.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    51. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 01; 69(15):6232-40. Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham RT, Nowak P, Zask A. PMID: 19584280.
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    52. Regulation of the mTOR signaling pathway: from laboratory bench to bedside and back again. F1000 Biol Rep. 2009 Jan 21; 1:8. Abraham RT. PMID: 20948608; PMCID: PMC2920679.
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    53. Moving out: mobilizing activated T cells from lymphoid tissues. Nat Immunol. 2008 May; 9(5):455-7. Berstein G, Abraham RT. PMID: 18425096.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    54. A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis. Cancer Res. 2008 Apr 15; 68(8):2934-43. Shor B, Zhang WG, Toral-Barza L, Lucas J, Abraham RT, Gibbons JJ, Yu K. PMID: 18413763.
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    55. A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2008 May 09; 283(19):13174-84. Oliveira V, Romanow WJ, Geisen C, Otterness DM, Mercurio F, Wang HG, Dalton WS, Abraham RT. PMID: 18326048; PMCID: PMC2442360.
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    56. A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. Cancer Res. 2008 Feb 15; 68(4):1144-53. Amornphimoltham P, Patel V, Leelahavanichkul K, Abraham RT, Gutkind JS. PMID: 18281490; PMCID: PMC3443567.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    57. Mammalian target of rapamycin as a therapeutic target in oncology. Expert Opin Ther Targets. 2008 Feb; 12(2):209-22. Abraham RT, Eng CH. PMID: 18208369.
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    58. Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines. Mol Cancer Ther. 2007 Nov; 6(11):3028-38. Toral-Barza L, Zhang WG, Huang X, McDonald LA, Salaski EJ, Barbieri LR, Ding WD, Krishnamurthy G, Hu YB, Lucas J, Bernan VS, Cai P, Levin JI, Mansour TS, Gibbons JJ, Abraham RT, Yu K. PMID: 17989320.
      View in: PubMed   Mentions:
    59. Targeting the mTOR signaling network in cancer. Trends Mol Med. 2007 Oct; 13(10):433-42. Chiang GG, Abraham RT. PMID: 17905659.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    60. The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol Cancer Ther. 2007 Sep; 6(9):2505-14. Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, Abraham RT. PMID: 17766839.
      View in: PubMed   Mentions:
    61. SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. Mol Immunol. 2008 Jan; 45(2):510-22. Kosco KA, Cerignoli F, Williams S, Abraham RT, Mustelin T. PMID: 17658605.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    62. The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res. 2007 Jun 01; 13(11):3109-14. Abraham RT, Gibbons JJ. PMID: 17545512.
      View in: PubMed   Mentions:
    63. The FRB domain of mTOR: NMR solution structure and inhibitor design. Biochemistry. 2006 Aug 29; 45(34):10294-302. Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham RT, Pellecchia M. PMID: 16922504.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    64. Signalomic signatures enlighten drug profiling. Nat Chem Biol. 2006 Jun; 2(6):295-6. Abraham RT. PMID: 16710334.
      View in: PubMed   Mentions:
    65. The functional role of Cdc6 in S-G2/M in mammalian cells. EMBO Rep. 2006 Apr; 7(4):425-30. Lau E, Zhu C, Abraham RT, Jiang W. PMID: 16439999; PMCID: PMC1456921.
      View in: PubMed   Mentions:
    66. Turning the replication checkpoint on and off. Cell Cycle. 2006 Jan; 5(2):125-8. Zhang YW, Hunter T, Abraham RT. PMID: 16357541.
      View in: PubMed   Mentions:
    67. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell. 2005 Sep 02; 19(5):607-18. Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, Mercurio F, Abraham RT. PMID: 16137618.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    68. The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther. 2005 Sep; 4(9):1349-57. Ihle NT, Paine-Murrieta G, Berggren MI, Baker A, Tate WR, Wipf P, Abraham RT, Kirkpatrick DL, Powis G. PMID: 16170026; PMCID: PMC1432090.
      View in: PubMed   Mentions:
    69. Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer. Cancer Res. 2005 Jun 15; 65(12):5325-36. Liu M, Howes A, Lesperance J, Stallcup WB, Hauser CA, Kadoya K, Oshima RG, Abraham RT. PMID: 15958580.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    70. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem. 2005 Jul 08; 280(27):25485-90. Chiang GG, Abraham RT. PMID: 15899889.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansCells
    71. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol. 2005 Jun; 6(6):608-17. Phee H, Abraham RT, Weiss A. PMID: 15864311.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    72. Cell biology. Guiding ATM to broken DNA. Science. 2005 Apr 22; 308(5721):510-1. Abraham RT, Tibbetts RS. PMID: 15845843.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    73. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell. 2005 Jul; 16(7):3187-99. Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT, Jiang W. PMID: 15843429; PMCID: PMC1165403.
      View in: PubMed   Mentions:
    74. Part-time cop nabs deviant DNA. Nat Med. 2005 Mar; 11(3):257-8. Abraham RT. PMID: 15746937.
      View in: PubMed   Mentions:
    75. TOR signaling: an odyssey from cellular stress to the cell growth machinery. Curr Biol. 2005 Feb 22; 15(4):R139-41. Abraham RT. PMID: 15723787.
      View in: PubMed   Mentions:
    76. MAPKAP kinase-2: three's company at the G(2) checkpoint. Mol Cell. 2005 Jan 21; 17(2):163-4. Abraham RT. PMID: 15664183.
      View in: PubMed   Mentions:
    77. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J. 2004 Nov 24; 23(23):4660-9. Tsao CC, Geisen C, Abraham RT. PMID: 15538388; PMCID: PMC533049.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    78. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 01; 12(17):4749-59. Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. PMID: 15358300.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    79. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):883-7. Abraham RT. PMID: 15279773.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    80. The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):919-25. Abraham RT. PMID: 15279777.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    81. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J. 2004 Aug 04; 23(15):3164-74. Fang Y, Tsao CC, Goodman BK, Furumai R, Tirado CA, Abraham RT, Wang XF. PMID: 15282542; PMCID: PMC514932.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    82. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell. 2004 Jun 04; 14(5):585-98. Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT. PMID: 15175154.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    83. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol. 2004 Apr; 4(4):301-8. Abraham RT, Weiss A. PMID: 15057788.
      View in: PubMed   Mentions: 264     Fields:    Translation:HumansAnimalsCells
    84. Differential regulation of TCR-mediated gene transcription by Vav family members. J Exp Med. 2004 Feb 02; 199(3):429-34. Zakaria S, Gomez TS, Savoy DN, McAdam S, Turner M, Abraham RT, Billadeau DD. PMID: 14757747; PMCID: PMC2211790.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    85. Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev. 2004 Feb 01; 18(3):249-54. Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean NM, Abraham RT, Wang XF. PMID: 14871926; PMCID: PMC338278.
      View in: PubMed   Mentions:
    86. Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family. Methods Mol Biol. 2004; 281:125-41. Chiang GG, Abraham RT. PMID: 15220525.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    87. mTOR as a positive regulator of tumor cell responses to hypoxia. Curr Top Microbiol Immunol. 2004; 279:299-319. Abraham RT. PMID: 14560965.
      View in: PubMed   Mentions:
    88. Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Res. 2003 Dec 01; 63(23):8451-60. Edinger AL, Linardic CM, Chiang GG, Thompson CB, Abraham RT. PMID: 14679009.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    89. SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol. 2003 Aug 01; 171(3):1360-8. Zeng R, Cannon JL, Abraham RT, Way M, Billadeau DD, Bubeck-Wardenberg J, Burkhardt JK. PMID: 12874226.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    90. Rap1 redux. Nat Immunol. 2003 Aug; 4(8):725-7. Abraham RT. PMID: 12888790.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    91. Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase. Bioessays. 2003 Jul; 25(7):627-30. Abraham RT. PMID: 12815717.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    92. Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin. Mol Cancer Ther. 2003 Jun; 2(6):517-26. Fang Y, Linardic CM, Richardson DA, Cai W, Behforouz M, Abraham RT. PMID: 12813130.
      View in: PubMed   Mentions:
    93. A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nat Cell Biol. 2003 Apr; 5(4):309-19. Plattner R, Irvin BJ, Guo S, Blackburn K, Kazlauskas A, Abraham RT, York JD, Pendergast AM. PMID: 12652307.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    94. Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement. J Immunol. 2003 Mar 15; 170(6):2895-903. Piccolella E, Spadaro F, Ramoni C, Marinari B, Costanzo A, Levrero M, Thomson L, Abraham RT, Tuosto L. PMID: 12626540.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    95. Checkpoint signalling: focusing on 53BP1. Nat Cell Biol. 2002 Dec; 4(12):E277-9. Abraham RT. PMID: 12461529.
      View in: PubMed   Mentions:
    96. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell. 2002 Dec; 10(6):1269-81. Sasahara Y, Rachid R, Byrne MJ, de la Fuente MA, Abraham RT, Ramesh N, Geha RS. PMID: 12504004.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    97. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol. 2003 Jan; 4(1):44-8. Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, Abraham RT, Schoenberger SP, Mustelin T. PMID: 12447358.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    98. The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin. Mol Cell Biol. 2002 Nov; 22(21):7428-38. McMahon LP, Choi KM, Lin TA, Abraham RT, Lawrence JC. PMID: 12370290; PMCID: PMC135667.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    99. Identification of TOR signaling complexes: more TORC for the cell growth engine. Cell. 2002 Oct 04; 111(1):9-12. Abraham RT. PMID: 12372295.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    100. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002 Oct; 22(20):7004-14. Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. PMID: 12242281; PMCID: PMC139825.
      View in: PubMed   Mentions: 381     Fields:    Translation:HumansCells
    101. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J. 2002 Sep 16; 21(18):4809-19. Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham RT. PMID: 12234921; PMCID: PMC126295.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    102. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 2002 Aug 15; 16(16):2045-57. Hamad NM, Elconin JH, Karnoub AE, Bai W, Rich JN, Abraham RT, Der CJ, Counter CM. PMID: 12183360; PMCID: PMC186434.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    103. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem. 2002 Jul 05; 277(27):24220-4. Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT, Couture C, Mustelin T. PMID: 11976341.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    104. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol. 2002 Apr 15; 157(2):253-63. Villalba M, Bi K, Hu J, Altman Y, Bushway P, Reits E, Neefjes J, Baier G, Abraham RT, Altman A. PMID: 11956228; PMCID: PMC2199257.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    105. Protein tyrosine phosphorylation in T cell signaling. Front Biosci. 2002 Apr 01; 7:d918-69. Mustelin T, Abraham RT, Rudd CE, Alonso A, Merlo JJ. PMID: 11897562.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    106. Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol. 2002 Mar; 22(6):1834-43. Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. PMID: 11865061; PMCID: PMC135616.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    107. Antigen receptors rap to integrin receptors. Nat Immunol. 2002 Mar; 3(3):212-3. Abraham RT. PMID: 11875457.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    108. Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases. Bioorg Med Chem. 2002 Jan; 10(1):167-74. Peng H, Kim DI, Sarkaria JN, Cho YS, Abraham RT, Zalkow LH. PMID: 11738618.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    109. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 2001 Sep 01; 15(17):2177-96. Abraham RT. PMID: 11544175.
      View in: PubMed   Mentions:
    110. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature. 2001 Jun 21; 411(6840):969-74. Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF. PMID: 11418864.
      View in: PubMed   Mentions:
    111. Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. Eur J Biochem. 2001 Mar; 268(5):1508-15. Livolsi A, Busuttil V, Imbert V, Abraham RT, Peyron JF. PMID: 11231305.
      View in: PubMed   Mentions:
    112. Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. J Med Chem. 2001 Mar 01; 44(5):834-48. Peng H, Xie W, Otterness DM, Cogswell JP, McConnell RT, Carter HL, Powis G, Abraham RT, Zalkow LH. PMID: 11262093.
      View in: PubMed   Mentions:
    113. Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. Mol Cell Biol. 2000 Dec; 20(24):9149-61. Irvin BJ, Williams BL, Nilson AE, Maynor HO, Abraham RT. PMID: 11094067; PMCID: PMC102173.
      View in: PubMed   Mentions:
    114. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000 Dec 01; 14(23):2989-3002. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT. PMID: 11114888; PMCID: PMC317107.
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    115. Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. J Biol Chem. 2000 Oct 27; 275(43):33836-43. Mothe-Satney I, Brunn GJ, McMahon LP, Capaldo CT, Abraham RT, Lawrence JC. PMID: 10942774.
      View in: PubMed   Mentions:
    116. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000 Jul 01; 60(13):3504-13. Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT. PMID: 10910062.
      View in: PubMed   Mentions:
    117. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res. 2000 Apr 15; 60(8):2108-12. Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. PMID: 10786669.
      View in: PubMed   Mentions:
    118. Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase. Bioorg Med Chem. 2000 Feb; 8(2):299-306. Peng H, Xie W, Kim DI, Zalkow LH, Powis G, Otterness DM, Abraham RT. PMID: 10722152.
      View in: PubMed   Mentions:
    119. Use of mutant Jurkat T cell lines to define human natural killer cell surface receptor signaling pathways. Methods Mol Biol. 2000; 121:297-304. Binstadt BA, Williams BL, Abraham RT, Leibson PJ. PMID: 10818735.
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    120. Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways. Immunol Res. 2000; 22(2-3):95-117. Abraham RT. PMID: 11339369.
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    121. Redox regulation of calcineurin in T-lymphocytes. J Biol Inorg Chem. 1999 Oct; 4(5):632-44. Reiter TA, Abraham RT, Choi M, Rusnak F. PMID: 10550693.
      View in: PubMed   Mentions:
    122. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 1999 Sep 01; 59(17):4375-82. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT. PMID: 10485486.
      View in: PubMed   Mentions:
    123. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int Immunol. 1999 Jun; 11(6):943-50. Zhang W, Irvin BJ, Trible RP, Abraham RT, Samelson LE. PMID: 10360968.
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    124. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999 Jun 01; 13(11):1422-37. Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N. PMID: 10364159; PMCID: PMC316780.
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    125. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation. EMBO J. 1999 Apr 01; 18(7):1832-44. Williams BL, Irvin BJ, Sutor SL, Chini CC, Yacyshyn E, Bubeck Wardenburg J, Dalton M, Chan AC, Abraham RT. PMID: 10202147; PMCID: PMC1171269.
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    126. A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf. J Biol Chem. 1999 Mar 12; 274(11):7002-10. Sutor SL, Vroman BT, Armstrong EA, Abraham RT, Karnitz LM. PMID: 10066754.
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    127. Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J Immunol. 1999 Mar 01; 162(5):2453-6. Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Irvin BJ, Zhang W, Samelson LE, Abraham RT, Leibson PJ. PMID: 10072481.
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    128. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 1999 Feb 15; 59(4):886-94. Hosoi H, Dilling MB, Shikata T, Liu LN, Shu L, Ashmun RA, Germain GS, Abraham RT, Houghton PJ. PMID: 10029080.
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    129. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 1999 Jan 15; 13(2):152-7. Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C, Abraham RT. PMID: 9925639; PMCID: PMC316393.
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    130. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem. 1999 Jan 08; 274(2):1092-9. Iiboshi Y, Papst PJ, Kawasome H, Hosoi H, Abraham RT, Houghton PJ, Terada N. PMID: 9873056.
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    131. Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Mol Cell Biol. 1999 Jan; 19(1):948-56. Zhao Q, Williams BL, Abraham RT, Weiss A. PMID: 9858619; PMCID: PMC83953.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    132. Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel. J Med Chem. 1998 Nov 19; 41(24):4677-80. Peng H, Zalkow LH, Abraham RT, Powis G. PMID: 9822537.
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    133. Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol Pharmacol. 1998 Nov; 54(5):815-24. Hosoi H, Dilling MB, Liu LN, Danks MK, Shikata T, Sekulic A, Abraham RT, Lawrence JC, Houghton PJ. PMID: 9804616.
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    134. SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem. 1998 Oct 16; 273(42):27518-23. Binstadt BA, Billadeau DD, Jevremovic D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham RT, Leibson PJ. PMID: 9765283.
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    135. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 1998 Oct 01; 58(19):4375-82. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT. PMID: 9766667.
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    136. Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr Opin Immunol. 1998 Jun; 10(3):330-6. Abraham RT. PMID: 9638370.
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    137. Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signaling pathways. J Biol Chem. 1998 May 08; 273(19):11505-13. Kennedy AP, Sekulic A, Irvin BJ, Nilson AE, Dilworth SM, Abraham RT. PMID: 9565564.
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    138. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol. 1998 Mar; 18(3):1388-99. Williams BL, Schreiber KL, Zhang W, Wange RL, Samelson LE, Leibson PJ, Abraham RT. PMID: 9488454; PMCID: PMC108852.
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    139. Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. J Exp Med. 1997 Nov 17; 186(10):1713-24. Sloan-Lancaster J, Zhang W, Presley J, Williams BL, Abraham RT, Lippincott-Schwartz J, Samelson LE. PMID: 9362531; PMCID: PMC2199132.
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    140. PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem Sci. 1997 Sep; 22(9):345-9. Lawrence JC, Abraham RT. PMID: 9301335.
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    141. ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. J Immunol. 1997 Aug 01; 159(3):1135-9. Eischen CM, Williams BL, Zhang W, Samelson LE, Lynch DH, Abraham RT, Leibson PJ. PMID: 9233606.
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    142. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. 1997 Jul 04; 277(5322):99-101. Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ, Lawrence JC, Abraham RT. PMID: 9204908.
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    143. Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues. Cancer Chemother Pharmacol. 1997; 41(1):22-8. Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Dorr R, Dvorakova K, Salmon S, Harrison S, Worzalla J. PMID: 9443610.
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    144. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity. 1996 Dec; 5(6):629-38. Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ. PMID: 8986721.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    145. Cyclosporine in the treatment of dermatologic disease: an update. Mayo Clin Proc. 1996 Dec; 71(12):1182-91. Lim KK, Su WP, Schroeter AL, Sabers CJ, Abraham RT, Pittelkow MR. PMID: 8945493.
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    146. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 1996 Oct 01; 15(19):5256-67. Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC, Abraham RT. PMID: 8895571; PMCID: PMC452270.
      View in: PubMed   Mentions:
    147. Phosphatidylinositol 3-kinase related kinases. Curr Opin Immunol. 1996 Jun; 8(3):412-8. Abraham RT. PMID: 8793996.
      View in: PubMed   Mentions:
    148. Immunopharmacology of rapamycin. Annu Rev Immunol. 1996; 14:483-510. Abraham RT, Wiederrecht GJ. PMID: 8717522.
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    149. Interleukin-2 receptor signaling mechanisms. Adv Immunol. 1996; 61:147-99. Karnitz LM, Abraham RT. PMID: 8834496.
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    150. Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem. 1995 Dec 01; 270(48):28858-63. Evans GA, Goldsmith MA, Johnston JA, Xu W, Weiler SR, Erwin R, Howard OM, Abraham RT, O'Shea JJ, Greene WC, et al. PMID: 7499411.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    151. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. J Biol Chem. 1995 Nov 03; 270(44):26511-22. Lam E, Martin MM, Timerman AP, Sabers C, Fleischer S, Lukas T, Abraham RT, O'Keefe SJ, O'Neill EA, Wiederrecht GJ. PMID: 7592869.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    152. Fc receptor stimulation of PI 3-kinase in NK cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. Ann N Y Acad Sci. 1995 Sep 07; 766:209-13. Bonnema JD, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ. PMID: 7486660.
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    153. Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells. J Biol Chem. 1995 Jul 07; 270(27):16415-21. Ting AT, Dick CJ, Schoon RA, Karnitz LM, Abraham RT, Leibson PJ. PMID: 7541798.
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    154. Tyrosine phosphorylation is required for eosinophil degranulation induced by immobilized immunoglobulins. J Immunol. 1995 Jul 01; 155(1):357-66. Kato M, Abraham RT, Kita H. PMID: 7602111.
      View in: PubMed   Mentions:
    155. Cytokine receptor signaling mechanisms. Curr Opin Immunol. 1995 Jun; 7(3):320-6. Karnitz LM, Abraham RT. PMID: 7546395.
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    156. Novel quinone antiproliferative inhibitors of phosphatidylinositol-3-kinase. Anticancer Drug Des. 1995 Jun; 10(4):347-59. Frew T, Powis G, Berggren M, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Hudson C, Gruszecka-Kowalik E, Burgess EM, et al. PMID: 7786399.
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    157. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol Cell Biol. 1995 Jun; 15(6):3049-57. Karnitz LM, Burns LA, Sutor SL, Blenis J, Abraham RT. PMID: 7760801; PMCID: PMC230536.
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    158. Protein-tyrosine kinase-dependent activation of STAT transcription factors in interleukin-2- or interleukin-4-stimulated T lymphocytes. J Biol Chem. 1995 May 12; 270(19):11628-35. Brunn GJ, Falls EL, Nilson AE, Abraham RT. PMID: 7744803.
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    159. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 1995 Jan 13; 270(2):815-22. Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, Abraham RT. PMID: 7822316.
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    160. Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res. 1995; 1:53-71. Wiederrecht GJ, Sabers CJ, Brunn GJ, Martin MM, Dumont FJ, Abraham RT. PMID: 9552353.
      View in: PubMed   Mentions:
    161. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol Cell. 1995; 83(2-3):105-20. Abraham RT, Acquarone M, Andersen A, Asensi A, Bellé R, Berger F, Bergounioux C, Brunn G, Buquet-Fagot C, Fagot D, et al. PMID: 7549905.
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    162. Tyrosine phosphorylation and inositol phosphate production: are early events in human eosinophil activation stimulated by immobilized secretory IgA and IgG? J Allergy Clin Immunol. 1994 Dec; 94(6 Pt 2):1272-81. Kita H, Kato M, Gleich GJ, Abraham RT. PMID: 7798568.
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    163. A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors. Anticancer Res. 1994 Nov-Dec; 14(6B):2425-8. Frew T, Powis G, Berggren M, Abraham RT, Ashendel CL, Zalkow LH, Hudson C, Qazia S, Gruszecka-Kowalik E, Merriman R, et al. PMID: 7872663.
      View in: PubMed   Mentions:
    164. Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. J Exp Med. 1994 Oct 01; 180(4):1427-35. Bonnema JD, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ. PMID: 7931075; PMCID: PMC2191702.
      View in: PubMed   Mentions:
    165. A multisample assay for inhibitors of phosphatidylinositol phospholipase C: identification of naturally occurring peptide inhibitors with antiproliferative activity. Anticancer Drug Des. 1994 Aug; 9(4):353-61. Hill SR, Bonjouklian R, Powis G, Abraham RT, Ashendel CL, Zalkow LH. PMID: 7916901.
      View in: PubMed   Mentions:
    166. The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line. J Exp Med. 1994 Jun 01; 179(6):1799-808. Karnitz LM, Sutor SL, Abraham RT. PMID: 7515100; PMCID: PMC2191517.
      View in: PubMed   Mentions:
    167. Cytokine-enhanced NK cell-mediated cytotoxicity. Positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J Immunol. 1994 Mar 01; 152(5):2098-104. Bonnema JD, Rivlin KA, Ting AT, Schoon RA, Abraham RT, Leibson PJ. PMID: 7907631.
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    168. Proximal signals and the control of S-phase entry in interleukin-2-stimulated T lymphocytes. Adv Exp Med Biol. 1994; 365:197-210. Abraham RT, Karnitz LM, Burns LA, Brunn GJ. PMID: 7887304.
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    169. Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues. Cancer Chemother Pharmacol. 1994; 34(4):344-50. Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Grindey GB, Bonjouklian R. PMID: 8033301.
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    170. Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes. J Biol Chem. 1993 Oct 25; 268(30):22737-45. Morice WG, Wiederrecht G, Brunn GJ, Siekierka JJ, Abraham RT. PMID: 8226784.
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    171. Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes. J Biol Chem. 1993 Aug 25; 268(24):17659-61. Burns LA, Karnitz LM, Sutor SL, Abraham RT. PMID: 7688728.
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    172. A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell. J Biol Chem. 1993 May 25; 268(15):11119-24. Lutz MP, Sutor SL, Abraham RT, Miller LJ. PMID: 7684371.
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    173. Inhibition of protein tyrosine phosphatase by the antitumor agent gallium nitrate. Cancer Res. 1993 Apr 15; 53(8):1862-6. Berggren MM, Burns LA, Abraham RT, Powis G. PMID: 8467506.
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    174. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J Biol Chem. 1993 Mar 15; 268(8):5886-93. Secrist JP, Burns LA, Karnitz L, Koretzky GA, Abraham RT. PMID: 8383678.
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    175. Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes. J Biol Chem. 1993 Feb 15; 268(5):3734-8. Morice WG, Brunn GJ, Wiederrecht G, Siekierka JJ, Abraham RT. PMID: 8429048.
      View in: PubMed   Mentions:
    176. Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells. J Exp Med. 1992 Dec 01; 176(6):1751-5. Ting AT, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ. PMID: 1281218; PMCID: PMC2119449.
      View in: PubMed   Mentions:
    177. Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis. J Biol Chem. 1992 Nov 25; 267(33):23957-62. Ting AT, Schoon RA, Abraham RT, Leibson PJ. PMID: 1429733.
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    178. Interleukin-2 signal transduction in human NK cells: multisite phosphorylation and activation of the tyrosine kinase p56lck. J Leukoc Biol. 1992 Nov; 52(5):565-71. Einspahr KJ, Abraham RT, Dick CJ, Leibson PJ. PMID: 1385559.
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    179. Signal transduction through the T-cell antigen receptor. Trends Biochem Sci. 1992 Oct; 17(10):434-8. Abraham RT, Karnitz LM, Secrist JP, Leibson PJ. PMID: 1455512.
      View in: PubMed   Mentions:
    180. Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol Cell Biol. 1992 Oct; 12(10):4521-30. Karnitz L, Sutor SL, Torigoe T, Reed JC, Bell MP, McKean DJ, Leibson PJ, Abraham RT. PMID: 1406641; PMCID: PMC360378.
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    181. Condensed tannin promotes the release of arachidonic acid from rabbit resident alveolar macrophages. Am J Respir Cell Mol Biol. 1992 Aug; 7(2):172-81. Kreofsky T, Schlager JW, Vuk-Pavlovic Z, Abraham RT, Rohrbach MS. PMID: 1497906.
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    182. Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation. J Immunol. 1991 Nov 15; 147(10):3466-73. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT. PMID: 1719078.
      View in: PubMed   Mentions:
    183. Fc gamma receptor signal transduction in natural killer cells. Coupling to phospholipase C via a G protein-independent, but tyrosine kinase-dependent pathway. J Immunol. 1991 Nov 01; 147(9):3122-7. Ting AT, Einspahr KJ, Abraham RT, Leibson PJ. PMID: 1833464.
      View in: PubMed   Mentions:
    184. Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes. Mol Cell Biol. 1991 Sep; 11(9):4431-40. Augustine JA, Sutor SL, Abraham RT. PMID: 1652056; PMCID: PMC361306.
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    185. Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6279-83. Einspahr KJ, Abraham RT, Binstadt BA, Uehara Y, Leibson PJ. PMID: 2068107; PMCID: PMC52066.
      View in: PubMed   Mentions:
    186. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1. J Biol Chem. 1991 Jul 05; 266(19):12135-9. Secrist JP, Karnitz L, Abraham RT. PMID: 2061301.
      View in: PubMed   Mentions:
    187. Defective T-lymphocyte signal transduction and function in leukocyte adhesion deficiency. J Clin Immunol. 1991 Jul; 11(4):175-83. Voss LM, Abraham RT, Rhodes KH, Schoon RA, Leibson PJ. PMID: 1918265.
      View in: PubMed   Mentions:
    188. Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism. J Immunol. 1991 May 01; 146(9):2889-97. Augustine JA, Secrist JP, Daniels JK, Leibson PJ, Abraham RT. PMID: 1707924.
      View in: PubMed   Mentions:
    189. Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate. J Immunol. 1991 Apr 15; 146(8):2712-8. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT. PMID: 1707917.
      View in: PubMed   Mentions:
    190. Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine. J Biol Chem. 1990 Nov 25; 265(33):20394-400. Secrist JP, Sehgal I, Powis G, Abraham RT. PMID: 2173705.
      View in: PubMed   Mentions:
    191. Transmembrane signaling during natural killer cell-mediated cytotoxicity. Regulation by protein kinase C activation. J Immunol. 1990 Sep 01; 145(5):1498-504. Leibson PJ, Midthun DE, Windebank KP, Abraham RT. PMID: 2166762.
      View in: PubMed   Mentions:
    192. Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells. J Immunol. 1990 Sep 01; 145(5):1490-7. Einspahr KJ, Abraham RT, Dick CJ, Leibson PJ. PMID: 1696599.
      View in: PubMed   Mentions:
    193. Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells. Biochim Biophys Acta. 1990 May 02; 1052(2):313-22. Augustine JA, Schlager JW, Abraham RT. PMID: 2334739.
      View in: PubMed   Mentions:
    194. Doxorubicin blocks the increase in intracellular Ca++, part of a second messenger system in N1E-115 murine neuroblastoma cells. J Pharmacol Exp Ther. 1990 Mar; 252(3):979-83. Oakes SG, Schlager JJ, Santone KS, Abraham RT, Powis G. PMID: 2319480.
      View in: PubMed   Mentions:
    195. Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression. J Immunol. 1990 Mar 01; 144(5):1767-76. Ruegemer JJ, Ho SN, Augustine JA, Schlager JW, Bell MP, McKean DJ, Abraham RT. PMID: 2407783.
      View in: PubMed   Mentions:
    196. Differential responsiveness to phorbol esters correlates with differential expression of protein kinase C in KG-1 and KG-1a human myeloid leukemia cells. Biochim Biophys Acta. 1989 Sep 04; 1013(1):47-54. Hooper WC, Abraham RT, Ashendel CL, Woloschak GE. PMID: 2790038.
      View in: PubMed   Mentions:
    197. Signal transduction mechanisms in human natural killer cells mediating antitumor immunity. Haematol Blood Transfus. 1989; 32:281-3. Leibson PJ, Windebank KP, Barna TJ, Abraham RT. PMID: 2560445.
      View in: PubMed   Mentions:
    198. Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP. J Immunol. 1988 Dec 01; 141(11):3951-7. Windebank KP, Abraham RT, Powis G, Olsen RA, Barna TJ, Leibson PJ. PMID: 2846696.
      View in: PubMed   Mentions:
    199. Inhibition of T-cell antigen receptor-mediated transmembrane signaling by protein kinase C activation. Mol Cell Biol. 1988 Dec; 8(12):5448-58. Abraham RT, Ho SN, Barna TJ, Rusovick KM, McKean DJ. PMID: 2977423; PMCID: PMC365648.
      View in: PubMed   Mentions:
    200. Interleukin 1-mediated activation of interleukin 4 (IL 4)-producing T lymphocytes. Proliferation by IL 4-dependent and IL 4-independent mechanisms. J Immunol. 1987 Sep 01; 139(5):1532-40. Ho SN, Abraham RT, Nilson A, Handwerger BS, McKean DJ. PMID: 3114369.
      View in: PubMed   Mentions:
    201. Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism. J Biol Chem. 1987 Feb 25; 262(6):2719-28. Abraham RT, Ho SN, Barna TJ, McKean DJ. PMID: 3029093.
      View in: PubMed   Mentions:
    202. Stimulation of arachidonic acid release and eicosanoid biosynthesis in an interleukin 2-dependent T cell line. J Immunopharmacol. 1986; 8(2):165-204. Abraham RT, McKinney MM, Forray C, Shipley GD, Handwerger BS. PMID: 3088127.
      View in: PubMed   Mentions:
    203. Influence of hepatic oxidative metabolism on the immunosuppressive activities of 6-thiopurines. J Pharmacol Exp Ther. 1985 Sep; 234(3):670-6. Abraham RT, Benson LM, Jardine I. PMID: 3162017.
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    204. Synthesis and pH-dependent stability of purine-6-sulfenic acid, a putative reactive metabolite of 6-thiopurine. J Med Chem. 1983 Oct; 26(10):1523-6. Abraham RT, Benson LM, Jardine I. PMID: 6684689.
      View in: PubMed   Mentions:
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