Robert Abraham

Title(s)Adjunct Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Roles of ATM and ATR Kinases in DNA Damage Responses
    NIH/NCI R01CA097950Mar 1, 2002 - Feb 28, 2007
    Role: Co-Principal Investigator
    Cellular Pharmacology of Rapamycin
    NIH/NCI R01CA076193Dec 8, 1997 - Feb 28, 2009
    Role: Co-Principal Investigator
    SIGNAL TRANSDUCTION FROM THE T CELL ANTIGEN RECEPTOR
    NIH/NIGMS R01GM047286May 1, 1992 - Jul 31, 2005
    Role: Principal Investigator
    Cancer Center Support Grant (CCSG)
    NIH/NCI P30CA030199Jul 1, 1981 - Apr 30, 2020
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Formation of a low-mass galaxy from star clusters in a 600-million-year-old Universe. Nature. 2024 Dec; 636(8042):332-336. Mowla L, Iyer K, Asada Y, Desprez G, Tan VYY, Martis N, Sarrouh G, Strait V, Abraham R, Bradac M, Brammer G, Muzzin A, Pacifici C, Ravindranath S, Sawicki M, Willott C, Estrada-Carpenter V, Jahan N, Noirot G, Matharu J, Rihtaršic G, Zabl J. PMID: 39663487; PMCID: PMC11634762.
      View in: PubMed   Mentions:    Fields:    
    2. Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature. 2024 Jul; 631(8021):E12. Baltgalvis KA, Lamb KN, Symons KT, Wu CC, Hoffman MA, Snead AN, Song X, Glaza T, Kikuchi S, Green JC, Rogness DC, Lam B, Rodriguez-Aguirre ME, Woody DR, Eissler CL, Rodiles S, Negron SM, Bernard SM, Tran E, Pollock J, Tabatabaei A, Contreras V, Williams HN, Pastuszka MK, Sigler JJ, Pettazzoni P, Rudolph MG, Classen M, Brugger D, Claiborne C, Plancher JM, Cuartas I, Seoane J, Burgess LE, Abraham RT, Weinstein DS, Simon GM, Patricelli MP, Kinsella TM. PMID: 38961306.
      View in: PubMed   Mentions:    Fields:    
    3. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature. 2024 May; 629(8011):435-442. Baltgalvis KA, Lamb KN, Symons KT, Wu CC, Hoffman MA, Snead AN, Song X, Glaza T, Kikuchi S, Green JC, Rogness DC, Lam B, Rodriguez-Aguirre ME, Woody DR, Eissler CL, Rodiles S, Negron SM, Bernard SM, Tran E, Pollock J, Tabatabaei A, Contreras V, Williams HN, Pastuszka MK, Sigler JJ, Pettazzoni P, Rudolph MG, Classen M, Brugger D, Claiborne C, Plancher JM, Cuartas I, Seoane J, Burgess LE, Abraham RT, Weinstein DS, Simon GM, Patricelli MP, Kinsella TM. PMID: 38658751.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    4. A trail of dark-matter-free galaxies from a bullet-dwarf collision. Nature. 2022 05; 605(7910):435-439. van Dokkum P, Shen Z, Keim MA, Trujillo-Gomez S, Danieli S, Dutta Chowdhury D, Abraham R, Conroy C, Kruijssen JMD, Nagai D, Romanowsky A. PMID: 35585344; PMCID: PMC9117144.
      View in: PubMed   Mentions: 1     Fields:    
    5. Direct control of CAR T cells through small molecule-regulated antibodies. Nat Commun. 2021 01 29; 12(1):710. Park S, Pascua E, Lindquist KC, Kimberlin C, Deng X, Mak YSL, Melton Z, Johnson TO, Lin R, Boldajipour B, Abraham RT, Pons J, Sasu BJ, Van Blarcom TJ, Chaparro-Riggers J. PMID: 33514714; PMCID: PMC7846603.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    6. Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells. Cell Cycle. 2021 01; 20(1):65-80. Maskey RS, Wang F, Lehman E, Wang Y, Emmanuel N, Zhong W, Jin G, Abraham RT, Arndt KT, Myers JS, Mazurek A. PMID: 33356791; PMCID: PMC7849761.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    7. Anti-tumor immunity influences cancer cell reliance upon ATG7. Oncoimmunology. 2020 08 23; 9(1):1800162. Arensman MD, Yang XS, Zhong W, Bisulco S, Upeslacis E, Rosfjord EC, Deng S, Abraham RT, Eng CH. PMID: 32923161; PMCID: PMC7458662.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    8. A sugary input to leucine sensing. Science. 2020 01 10; 367(6474):146-147. Lehman E, Abraham RT. PMID: 31919209.
      View in: PubMed   Mentions: 3     Fields:    
    9. Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9533-9542. Arensman MD, Yang XS, Leahy DM, Toral-Barza L, Mileski M, Rosfjord EC, Wang F, Deng S, Myers JS, Abraham RT, Eng CH. PMID: 31019077; PMCID: PMC6511047.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    10. A galaxy lacking dark matter. Nature. 2018 03 28; 555(7698):629-632. van Dokkum P, Danieli S, Cohen Y, Merritt A, Romanowsky AJ, Abraham R, Brodie J, Conroy C, Lokhorst D, Mowla L, O'Sullivan E, Zhang J. PMID: 29595770.
      View in: PubMed   Mentions: 3     Fields:    
    11. The PI3K Pathway in Human Disease. Cell. 2017 Aug 10; 170(4):605-635. Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. PMID: 28802037; PMCID: PMC5726441.
      View in: PubMed   Mentions: 1101     Fields:    Translation:HumansAnimalsCells
    12. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 06 27; 19(13):2665-2680. Emmanuel N, Ragunathan S, Shan Q, Wang F, Giannakou A, Huser N, Jin G, Myers J, Abraham RT, Unsal-Kacmaz K. PMID: 28658616.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    13. The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration. Mol Cell. 2017 Mar 16; 65(6):959-960. Ihle NT, Abraham RT. PMID: 28306509.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Lysosomal adaptation: How cells respond to lysosomotropic compounds. PLoS One. 2017; 12(3):e0173771. Lu S, Sung T, Lin N, Abraham RT, Jessen BA. PMID: 28301521; PMCID: PMC5354416.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    15. 4E-BP2 hardwires lymphocytes for rapamycin sensitivity. Sci Signal. 2016 05 31; 9(430):fs10. Abraham RT. PMID: 27245610.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation. Cell Metab. 2016 Mar 08; 23(3):397-8. Abraham RT. PMID: 26959180.
      View in: PubMed   Mentions: 1     Fields:    
    17. Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):182-7. Eng CH, Wang Z, Tkach D, Toral-Barza L, Ugwonali S, Liu S, Fitzgerald SL, George E, Frias E, Cochran N, De Jesus R, McAllister G, Hoffman GR, Bray K, Lemon L, Lucas J, Fantin VR, Abraham RT, Murphy LO, Nyfeler B. PMID: 26677873; PMCID: PMC4711870.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    18. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 01; 21(13):2905-10. VanArsdale T, Boshoff C, Arndt KT, Abraham RT. PMID: 25941111.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    19. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene. 2015 Nov 05; 34(45):5662-76. Strohecker AM, Joshi S, Possemato R, Abraham RT, Sabatini DM, White E. PMID: 25772235; PMCID: PMC4573377.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    20. Cell biology. Making sense of amino acid sensing. Science. 2015 Jan 09; 347(6218):128-9. Abraham RT. PMID: 25574008.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    21. Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion. Nat Commun. 2014 Sep 25; 5:4900. Shanware NP, Bray K, Eng CH, Wang F, Follettie M, Myers J, Fantin VR, Abraham RT. PMID: 25254627; PMCID: PMC4200525.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    22. Too little mTORC1 activity injures the liver. Cell Metab. 2014 Jul 01; 20(1):4-6. Abraham RT. PMID: 24988455.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    23. MTOR mutations in the crosshairs of targeted therapy. Cancer Discov. 2014 May; 4(5):513-5. Rejto PA, Abraham RT. PMID: 24795009.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Self-eating limits EGFR-dependent tumor growth. Cell. 2013 Sep 12; 154(6):1184-6. Fantin VR, Abraham RT. PMID: 24034240.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    25. The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics. Nat Prod Rep. 2013 May; 30(5):625-39. Gerber HP, Koehn FE, Abraham RT. PMID: 23525375.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    26. The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease. Annu Rev Pharmacol Toxicol. 2013; 53:89-106. Shanware NP, Bray K, Abraham RT. PMID: 23294306.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    27. Chemokine to the rescue: interleukin-8 mediates resistance to PI3K-pathway-targeted therapy in breast cancer. Cancer Cell. 2012 Dec 11; 22(6):703-5. Abraham RT. PMID: 23238010.
      View in: PubMed   Mentions: 10     Fields:    
    28. Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells. Mol Cancer Ther. 2013 Jan; 12(1):38-47. Sapra P, Damelin M, Dijoseph J, Marquette K, Geles KG, Golas J, Dougher M, Narayanan B, Giannakou A, Khandke K, Dushin R, Ernstoff E, Lucas J, Leal M, Hu G, O'Donnell CJ, Tchistiakova L, Abraham RT, Gerber HP. PMID: 23223830.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    29. Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies. Pigment Cell Melanoma Res. 2012 Nov; 25(6):819-31. Bagrodia S, Smeal T, Abraham RT. PMID: 22883054.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    30. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, et al. PMID: 22966490; PMCID: PMC3404883.
      View in: PubMed   Mentions: 1811     Fields:    Translation:HumansAnimals
    31. Serine biosynthesis: fuel for the melanoma cell growth engine. Pigment Cell Melanoma Res. 2011 Oct; 24(5):875-7. Dann SG, Abraham RT. PMID: 22081811.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    32. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol. 2011 Nov; 31(22):4417-29. Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, Ohno S, Yamashita A, Abraham RT, Gueven N, Lavin MF. PMID: 21911475; PMCID: PMC3209244.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    33. Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian target of rapamycin inhibitor, temsirolimus, in a preclinical mammary carcinoma OncoMouse model: a translational medicine study in support for early clinical development. J Pharmacol Exp Ther. 2011 Nov; 339(2):421-9. Wang X, Zhan Y, Zhao L, Alvarez J, Chaudhary I, Zhou BB, Abraham RT, Feuerstein GZ. PMID: 21835932.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming. Oncogene. 2011 Nov 24; 30(47):4687-96. Eng CH, Abraham RT. PMID: 21666712.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    35. Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells. Cancer Res. 2011 Jun 15; 71(12):4236-46. Damelin M, Geles KG, Follettie MT, Yuan P, Baxter M, Golas J, DiJoseph JF, Karnoub M, Huang S, Diesl V, Behrens C, Choe SE, Rios C, Gruzas J, Sridharan L, Dougher M, Kunz A, Hamann PR, Evans D, Armellino D, Khandke K, Marquette K, Tchistiakova L, Boghaert ER, Abraham RT, Wistuba II, Zhou BB. PMID: 21540235.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    36. Glutamine: pleiotropic roles in tumor growth and stress resistance. J Mol Med (Berl). 2011 Mar; 89(3):229-36. Shanware NP, Mullen AR, DeBerardinis RJ, Abraham RT. PMID: 21301794.
      View in: PubMed   Mentions: 110     Fields:    
    37. Glutaminolysis yields a metabolic by-product that stimulates autophagy. Autophagy. 2010 Oct; 6(7):968-70. Eng CH, Abraham RT. PMID: 20724823; PMCID: PMC3039742.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    38. A metabolic (re-)balancing act. Mol Cell. 2010 May 28; 38(4):481-2. Abraham RT, Eng CH. PMID: 20513422.
      View in: PubMed   Mentions: 4     Fields:    
    39. Lysosomal Rag-ulation of mTOR complex 1 activity. Cell Metab. 2010 May 05; 11(5):341-2. Abraham RT. PMID: 20444413.
      View in: PubMed   Mentions: 3     Fields:    
    40. Cancer and inflammation: promise for biologic therapy. J Immunother. 2010 May; 33(4):335-51. Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT. PMID: 20386472; PMCID: PMC2941912.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimals
    41. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal. 2010 Apr 27; 3(119):ra31. Eng CH, Yu K, Lucas J, White E, Abraham RT. PMID: 20424262.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    42. Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor. J Med Chem. 2010 Mar 25; 53(6):2636-45. Venkatesan AM, Dehnhardt CM, Delos Santos E, Chen Z, Dos Santos O, Ayral-Kaloustian S, Khafizova G, Brooijmans N, Mallon R, Hollander I, Feldberg L, Lucas J, Yu K, Gibbons J, Abraham RT, Chaudhary I, Mansour TS. PMID: 20166697.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    43. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem. 2010 May 28; 285(22):16562-71. Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang TH, Cordeiro-Stone M, Kaufmann WK, Abraham RT, Sancar A, Unsal-Kaçmaz K. PMID: 20233725; PMCID: PMC2878033.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    44. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res. 2010 Jan 15; 70(2):621-31. Yu K, Shi C, Toral-Barza L, Lucas J, Shor B, Kim JE, Zhang WG, Mahoney R, Gaydos C, Tardio L, Kim SK, Conant R, Curran K, Kaplan J, Verheijen J, Ayral-Kaloustian S, Mansour TS, Abraham RT, Zask A, Gibbons JJ. PMID: 20068177.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    45. Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle. 2009 Dec; 8(23):3831-7. Shor B, Gibbons JJ, Abraham RT, Yu K. PMID: 19901542.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    46. Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol. 2009 Dec; 36 Suppl 3:S3-S17. Gibbons JJ, Abraham RT, Yu K. PMID: 19963098.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    47. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell. 2009 Aug 28; 35(4):442-53. Zhang YW, Brognard J, Coughlin C, You Z, Dolled-Filhart M, Aslanian A, Manning G, Abraham RT, Hunter T. PMID: 19716789; PMCID: PMC2736145.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    48. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27; 52(16):5013-6. Zask A, Verheijen JC, Curran K, Kaplan J, Richard DJ, Nowak P, Malwitz DJ, Brooijmans N, Bard J, Svenson K, Lucas J, Toral-Barza L, Zhang WG, Hollander I, Gibbons JJ, Abraham RT, Ayral-Kaloustian S, Mansour TS, Yu K. PMID: 19645448.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    49. GOLPH3 links the Golgi network to mTOR signaling and human cancer. Pigment Cell Melanoma Res. 2009 Aug; 22(4):378-9. Abraham RT. PMID: 19624311.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    50. Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival. Mol Biol Cell. 2009 Sep; 20(17):3953-64. Lau E, Chiang GG, Abraham RT, Jiang W. PMID: 19587119; PMCID: PMC2735493.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    51. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 01; 69(15):6232-40. Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham RT, Nowak P, Zask A. PMID: 19584280.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCells
    52. Regulation of the mTOR signaling pathway: from laboratory bench to bedside and back again. F1000 Biol Rep. 2009 Jan 21; 1:8. Abraham RT. PMID: 20948608; PMCID: PMC2920679.
      View in: PubMed   Mentions: 6  
    53. Moving out: mobilizing activated T cells from lymphoid tissues. Nat Immunol. 2008 May; 9(5):455-7. Berstein G, Abraham RT. PMID: 18425096.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    54. A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis. Cancer Res. 2008 Apr 15; 68(8):2934-43. Shor B, Zhang WG, Toral-Barza L, Lucas J, Abraham RT, Gibbons JJ, Yu K. PMID: 18413763.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    55. A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2008 May 09; 283(19):13174-84. Oliveira V, Romanow WJ, Geisen C, Otterness DM, Mercurio F, Wang HG, Dalton WS, Abraham RT. PMID: 18326048; PMCID: PMC2442360.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    56. A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. Cancer Res. 2008 Feb 15; 68(4):1144-53. Amornphimoltham P, Patel V, Leelahavanichkul K, Abraham RT, Gutkind JS. PMID: 18281490; PMCID: PMC3443567.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    57. Mammalian target of rapamycin as a therapeutic target in oncology. Expert Opin Ther Targets. 2008 Feb; 12(2):209-22. Abraham RT, Eng CH. PMID: 18208369.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    58. Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines. Mol Cancer Ther. 2007 Nov; 6(11):3028-38. Toral-Barza L, Zhang WG, Huang X, McDonald LA, Salaski EJ, Barbieri LR, Ding WD, Krishnamurthy G, Hu YB, Lucas J, Bernan VS, Cai P, Levin JI, Mansour TS, Gibbons JJ, Abraham RT, Yu K. PMID: 17989320.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    59. Targeting the mTOR signaling network in cancer. Trends Mol Med. 2007 Oct; 13(10):433-42. Chiang GG, Abraham RT. PMID: 17905659.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    60. The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol Cancer Ther. 2007 Sep; 6(9):2505-14. Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, Abraham RT. PMID: 17766839.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    61. SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. Mol Immunol. 2008 Jan; 45(2):510-22. Kosco KA, Cerignoli F, Williams S, Abraham RT, Mustelin T. PMID: 17658605.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    62. The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res. 2007 Jun 01; 13(11):3109-14. Abraham RT, Gibbons JJ. PMID: 17545512.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    63. The FRB domain of mTOR: NMR solution structure and inhibitor design. Biochemistry. 2006 Aug 29; 45(34):10294-302. Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham RT, Pellecchia M. PMID: 16922504.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    64. Signalomic signatures enlighten drug profiling. Nat Chem Biol. 2006 Jun; 2(6):295-6. Abraham RT. PMID: 16710334.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    65. The functional role of Cdc6 in S-G2/M in mammalian cells. EMBO Rep. 2006 Apr; 7(4):425-30. Lau E, Zhu C, Abraham RT, Jiang W. PMID: 16439999; PMCID: PMC1456921.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    66. Turning the replication checkpoint on and off. Cell Cycle. 2006 Jan; 5(2):125-8. Zhang YW, Hunter T, Abraham RT. PMID: 16357541.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    67. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell. 2005 Sep 02; 19(5):607-18. Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, Mercurio F, Abraham RT. PMID: 16137618.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansCells
    68. The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther. 2005 Sep; 4(9):1349-57. Ihle NT, Paine-Murrieta G, Berggren MI, Baker A, Tate WR, Wipf P, Abraham RT, Kirkpatrick DL, Powis G. PMID: 16170026; PMCID: PMC1432090.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    69. Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer. Cancer Res. 2005 Jun 15; 65(12):5325-36. Liu M, Howes A, Lesperance J, Stallcup WB, Hauser CA, Kadoya K, Oshima RG, Abraham RT. PMID: 15958580.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    70. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem. 2005 Jul 08; 280(27):25485-90. Chiang GG, Abraham RT. PMID: 15899889.
      View in: PubMed   Mentions: 275     Fields:    Translation:HumansCells
    71. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol. 2005 Jun; 6(6):608-17. Phee H, Abraham RT, Weiss A. PMID: 15864311.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    72. Cell biology. Guiding ATM to broken DNA. Science. 2005 Apr 22; 308(5721):510-1. Abraham RT, Tibbetts RS. PMID: 15845843.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    73. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell. 2005 Jul; 16(7):3187-99. Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT, Jiang W. PMID: 15843429; PMCID: PMC1165403.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCells
    74. Part-time cop nabs deviant DNA. Nat Med. 2005 Mar; 11(3):257-8. Abraham RT. PMID: 15746937.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    75. TOR signaling: an odyssey from cellular stress to the cell growth machinery. Curr Biol. 2005 Feb 22; 15(4):R139-41. Abraham RT. PMID: 15723787.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    76. MAPKAP kinase-2: three's company at the G(2) checkpoint. Mol Cell. 2005 Jan 21; 17(2):163-4. Abraham RT. PMID: 15664183.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    77. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J. 2004 Nov 24; 23(23):4660-9. Tsao CC, Geisen C, Abraham RT. PMID: 15538388; PMCID: PMC533049.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    78. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 01; 12(17):4749-59. Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. PMID: 15358300.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    79. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):883-7. Abraham RT. PMID: 15279773.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    80. The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):919-25. Abraham RT. PMID: 15279777.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    81. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J. 2004 Aug 04; 23(15):3164-74. Fang Y, Tsao CC, Goodman BK, Furumai R, Tirado CA, Abraham RT, Wang XF. PMID: 15282542; PMCID: PMC514932.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    82. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell. 2004 Jun 04; 14(5):585-98. Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT. PMID: 15175154.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    83. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol. 2004 Apr; 4(4):301-8. Abraham RT, Weiss A. PMID: 15057788.
      View in: PubMed   Mentions: 260     Fields:    Translation:HumansAnimalsCells
    84. Differential regulation of TCR-mediated gene transcription by Vav family members. J Exp Med. 2004 Feb 02; 199(3):429-34. Zakaria S, Gomez TS, Savoy DN, McAdam S, Turner M, Abraham RT, Billadeau DD. PMID: 14757747; PMCID: PMC2211790.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    85. Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev. 2004 Feb 01; 18(3):249-54. Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean NM, Abraham RT, Wang XF. PMID: 14871926; PMCID: PMC338278.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    86. mTOR as a positive regulator of tumor cell responses to hypoxia. Curr Top Microbiol Immunol. 2004; 279:299-319. Abraham RT. PMID: 14560965.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    87. Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family. Methods Mol Biol. 2004; 281:125-41. Chiang GG, Abraham RT. PMID: 15220525.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    88. Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Res. 2003 Dec 01; 63(23):8451-60. Edinger AL, Linardic CM, Chiang GG, Thompson CB, Abraham RT. PMID: 14679009.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    89. SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol. 2003 Aug 01; 171(3):1360-8. Zeng R, Cannon JL, Abraham RT, Way M, Billadeau DD, Bubeck-Wardenberg J, Burkhardt JK. PMID: 12874226.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    90. Rap1 redux. Nat Immunol. 2003 Aug; 4(8):725-7. Abraham RT. PMID: 12888790.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    91. Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase. Bioessays. 2003 Jul; 25(7):627-30. Abraham RT. PMID: 12815717.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    92. Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin. Mol Cancer Ther. 2003 Jun; 2(6):517-26. Fang Y, Linardic CM, Richardson DA, Cai W, Behforouz M, Abraham RT. PMID: 12813130.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    93. A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nat Cell Biol. 2003 Apr; 5(4):309-19. Plattner R, Irvin BJ, Guo S, Blackburn K, Kazlauskas A, Abraham RT, York JD, Pendergast AM. PMID: 12652307.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    94. Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement. J Immunol. 2003 Mar 15; 170(6):2895-903. Piccolella E, Spadaro F, Ramoni C, Marinari B, Costanzo A, Levrero M, Thomson L, Abraham RT, Tuosto L. PMID: 12626540.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    95. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell. 2002 Dec; 10(6):1269-81. Sasahara Y, Rachid R, Byrne MJ, de la Fuente MA, Abraham RT, Ramesh N, Geha RS. PMID: 12504004.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    96. Checkpoint signalling: focusing on 53BP1. Nat Cell Biol. 2002 Dec; 4(12):E277-9. Abraham RT. PMID: 12461529.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    97. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol. 2003 Jan; 4(1):44-8. Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, Abraham RT, Schoenberger SP, Mustelin T. PMID: 12447358.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    98. The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin. Mol Cell Biol. 2002 Nov; 22(21):7428-38. McMahon LP, Choi KM, Lin TA, Abraham RT, Lawrence JC. PMID: 12370290; PMCID: PMC135667.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    99. Identification of TOR signaling complexes: more TORC for the cell growth engine. Cell. 2002 Oct 04; 111(1):9-12. Abraham RT. PMID: 12372295.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    100. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002 Oct; 22(20):7004-14. Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. PMID: 12242281; PMCID: PMC139825.
      View in: PubMed   Mentions: 458     Fields:    Translation:HumansCells
    101. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J. 2002 Sep 16; 21(18):4809-19. Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham RT. PMID: 12234921; PMCID: PMC126295.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    102. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 2002 Aug 15; 16(16):2045-57. Hamad NM, Elconin JH, Karnoub AE, Bai W, Rich JN, Abraham RT, Der CJ, Counter CM. PMID: 12183360; PMCID: PMC186434.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    103. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem. 2002 Jul 05; 277(27):24220-4. Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT, Couture C, Mustelin T. PMID: 11976341.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    104. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol. 2002 Apr 15; 157(2):253-63. Villalba M, Bi K, Hu J, Altman Y, Bushway P, Reits E, Neefjes J, Baier G, Abraham RT, Altman A. PMID: 11956228; PMCID: PMC2199257.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    105. Protein tyrosine phosphorylation in T cell signaling. Front Biosci. 2002 Apr 01; 7:d918-69. Mustelin T, Abraham RT, Rudd CE, Alonso A, Merlo JJ. PMID: 11897562.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    106. Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol. 2002 Mar; 22(6):1834-43. Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. PMID: 11865061; PMCID: PMC135616.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    107. Antigen receptors rap to integrin receptors. Nat Immunol. 2002 Mar; 3(3):212-3. Abraham RT. PMID: 11875457.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    108. Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases. Bioorg Med Chem. 2002 Jan; 10(1):167-74. Peng H, Kim DI, Sarkaria JN, Cho YS, Abraham RT, Zalkow LH. PMID: 11738618.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    109. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 2001 Sep 01; 15(17):2177-96. Abraham RT. PMID: 11544175.
      View in: PubMed   Mentions: 791     Fields:    Translation:HumansAnimalsCells
    110. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature. 2001 Jun 21; 411(6840):969-74. Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF. PMID: 11418864.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    111. Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. Eur J Biochem. 2001 Mar; 268(5):1508-15. Livolsi A, Busuttil V, Imbert V, Abraham RT, Peyron JF. PMID: 11231305.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    112. Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. J Med Chem. 2001 Mar 01; 44(5):834-48. Peng H, Xie W, Otterness DM, Cogswell JP, McConnell RT, Carter HL, Powis G, Abraham RT, Zalkow LH. PMID: 11262093.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    113. Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. Mol Cell Biol. 2000 Dec; 20(24):9149-61. Irvin BJ, Williams BL, Nilson AE, Maynor HO, Abraham RT. PMID: 11094067; PMCID: PMC102173.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    114. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000 Dec 01; 14(23):2989-3002. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT. PMID: 11114888; PMCID: PMC317107.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    115. Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. J Biol Chem. 2000 Oct 27; 275(43):33836-43. Mothe-Satney I, Brunn GJ, McMahon LP, Capaldo CT, Abraham RT, Lawrence JC. PMID: 10942774.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    116. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000 Jul 01; 60(13):3504-13. Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT. PMID: 10910062.
      View in: PubMed   Mentions: 250     Fields:    Translation:HumansAnimalsCells
    117. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res. 2000 Apr 15; 60(8):2108-12. Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. PMID: 10786669.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    118. Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase. Bioorg Med Chem. 2000 Feb; 8(2):299-306. Peng H, Xie W, Kim DI, Zalkow LH, Powis G, Otterness DM, Abraham RT. PMID: 10722152.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    119. Use of mutant Jurkat T cell lines to define human natural killer cell surface receptor signaling pathways. Methods Mol Biol. 2000; 121:297-304. Binstadt BA, Williams BL, Abraham RT, Leibson PJ. PMID: 10818735.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    120. Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways. Immunol Res. 2000; 22(2-3):95-117. Abraham RT. PMID: 11339369.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    121. Redox regulation of calcineurin in T-lymphocytes. J Biol Inorg Chem. 1999 Oct; 4(5):632-44. Reiter TA, Abraham RT, Choi M, Rusnak F. PMID: 10550693.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    122. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 1999 Sep 01; 59(17):4375-82. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT. PMID: 10485486.
      View in: PubMed   Mentions: 393     Fields:    Translation:HumansCells
    123. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int Immunol. 1999 Jun; 11(6):943-50. Zhang W, Irvin BJ, Trible RP, Abraham RT, Samelson LE. PMID: 10360968.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    124. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999 Jun 01; 13(11):1422-37. Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N. PMID: 10364159; PMCID: PMC316780.
      View in: PubMed   Mentions: 583     Fields:    Translation:HumansCells
    125. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation. EMBO J. 1999 Apr 01; 18(7):1832-44. Williams BL, Irvin BJ, Sutor SL, Chini CC, Yacyshyn E, Bubeck Wardenburg J, Dalton M, Chan AC, Abraham RT. PMID: 10202147; PMCID: PMC1171269.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    126. A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf. J Biol Chem. 1999 Mar 12; 274(11):7002-10. Sutor SL, Vroman BT, Armstrong EA, Abraham RT, Karnitz LM. PMID: 10066754.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    127. Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J Immunol. 1999 Mar 01; 162(5):2453-6. Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Irvin BJ, Zhang W, Samelson LE, Abraham RT, Leibson PJ. PMID: 10072481.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    128. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 1999 Feb 15; 59(4):886-94. Hosoi H, Dilling MB, Shikata T, Liu LN, Shu L, Ashmun RA, Germain GS, Abraham RT, Houghton PJ. PMID: 10029080.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    129. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 1999 Jan 15; 13(2):152-7. Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C, Abraham RT. PMID: 9925639; PMCID: PMC316393.
      View in: PubMed   Mentions: 339     Fields:    Translation:HumansCells
    130. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem. 1999 Jan 08; 274(2):1092-9. Iiboshi Y, Papst PJ, Kawasome H, Hosoi H, Abraham RT, Houghton PJ, Terada N. PMID: 9873056.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    131. Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Mol Cell Biol. 1999 Jan; 19(1):948-56. Zhao Q, Williams BL, Abraham RT, Weiss A. PMID: 9858619; PMCID: PMC83953.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    132. Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel. J Med Chem. 1998 Nov 19; 41(24):4677-80. Peng H, Zalkow LH, Abraham RT, Powis G. PMID: 9822537.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    133. Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol Pharmacol. 1998 Nov; 54(5):815-24. Hosoi H, Dilling MB, Liu LN, Danks MK, Shikata T, Sekulic A, Abraham RT, Lawrence JC, Houghton PJ. PMID: 9804616.
      View in: PubMed   Mentions: 43     Fields:    
    134. SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem. 1998 Oct 16; 273(42):27518-23. Binstadt BA, Billadeau DD, Jevremovic D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham RT, Leibson PJ. PMID: 9765283.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    135. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 1998 Oct 01; 58(19):4375-82. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT. PMID: 9766667.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansCells
    136. Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr Opin Immunol. 1998 Jun; 10(3):330-6. Abraham RT. PMID: 9638370.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    137. Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signaling pathways. J Biol Chem. 1998 May 08; 273(19):11505-13. Kennedy AP, Sekulic A, Irvin BJ, Nilson AE, Dilworth SM, Abraham RT. PMID: 9565564.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    138. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol. 1998 Mar; 18(3):1388-99. Williams BL, Schreiber KL, Zhang W, Wange RL, Samelson LE, Leibson PJ, Abraham RT. PMID: 9488454; PMCID: PMC108852.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    139. Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. J Exp Med. 1997 Nov 17; 186(10):1713-24. Sloan-Lancaster J, Zhang W, Presley J, Williams BL, Abraham RT, Lippincott-Schwartz J, Samelson LE. PMID: 9362531; PMCID: PMC2199132.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    140. PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem Sci. 1997 Sep; 22(9):345-9. Lawrence JC, Abraham RT. PMID: 9301335.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    141. ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. J Immunol. 1997 Aug 01; 159(3):1135-9. Eischen CM, Williams BL, Zhang W, Samelson LE, Lynch DH, Abraham RT, Leibson PJ. PMID: 9233606.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    142. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. 1997 Jul 04; 277(5322):99-101. Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ, Lawrence JC, Abraham RT. PMID: 9204908.
      View in: PubMed   Mentions: 333     Fields:    Translation:HumansAnimalsCells
    143. Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues. Cancer Chemother Pharmacol. 1997; 41(1):22-8. Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Dorr R, Dvorakova K, Salmon S, Harrison S, Worzalla J. PMID: 9443610.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    144. Cyclosporine in the treatment of dermatologic disease: an update. Mayo Clin Proc. 1996 Dec; 71(12):1182-91. Lim KK, Su WP, Schroeter AL, Sabers CJ, Abraham RT, Pittelkow MR. PMID: 8945493.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    145. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity. 1996 Dec; 5(6):629-38. Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ. PMID: 8986721.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    146. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 1996 Oct 01; 15(19):5256-67. Brunn GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC, Abraham RT. PMID: 8895571; PMCID: PMC452270.
      View in: PubMed   Mentions: 239     Fields:    Translation:AnimalsCells
    147. Phosphatidylinositol 3-kinase related kinases. Curr Opin Immunol. 1996 Jun; 8(3):412-8. Abraham RT. PMID: 8793996.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    148. Immunopharmacology of rapamycin. Annu Rev Immunol. 1996; 14:483-510. Abraham RT, Wiederrecht GJ. PMID: 8717522.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimals
    149. Interleukin-2 receptor signaling mechanisms. Adv Immunol. 1996; 61:147-99. Karnitz LM, Abraham RT. PMID: 8834496.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    150. Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem. 1995 Dec 01; 270(48):28858-63. Evans GA, Goldsmith MA, Johnston JA, Xu W, Weiler SR, Erwin R, Howard OM, Abraham RT, O'Shea JJ, Greene WC, et al. PMID: 7499411.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    151. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. J Biol Chem. 1995 Nov 03; 270(44):26511-22. Lam E, Martin MM, Timerman AP, Sabers C, Fleischer S, Lukas T, Abraham RT, O'Keefe SJ, O'Neill EA, Wiederrecht GJ. PMID: 7592869.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    152. Fc receptor stimulation of PI 3-kinase in NK cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. Ann N Y Acad Sci. 1995 Sep 07; 766:209-13. Bonnema JD, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ. PMID: 7486660.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    153. Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells. J Biol Chem. 1995 Jul 07; 270(27):16415-21. Ting AT, Dick CJ, Schoon RA, Karnitz LM, Abraham RT, Leibson PJ. PMID: 7541798.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    154. Tyrosine phosphorylation is required for eosinophil degranulation induced by immobilized immunoglobulins. J Immunol. 1995 Jul 01; 155(1):357-66. Kato M, Abraham RT, Kita H. PMID: 7602111.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    155. Cytokine receptor signaling mechanisms. Curr Opin Immunol. 1995 Jun; 7(3):320-6. Karnitz LM, Abraham RT. PMID: 7546395.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    156. Novel quinone antiproliferative inhibitors of phosphatidylinositol-3-kinase. Anticancer Drug Des. 1995 Jun; 10(4):347-59. Frew T, Powis G, Berggren M, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Hudson C, Gruszecka-Kowalik E, Burgess EM, et al. PMID: 7786399.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    157. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol Cell Biol. 1995 Jun; 15(6):3049-57. Karnitz LM, Burns LA, Sutor SL, Blenis J, Abraham RT. PMID: 7760801; PMCID: PMC230536.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    158. Protein-tyrosine kinase-dependent activation of STAT transcription factors in interleukin-2- or interleukin-4-stimulated T lymphocytes. J Biol Chem. 1995 May 12; 270(19):11628-35. Brunn GJ, Falls EL, Nilson AE, Abraham RT. PMID: 7744803.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    159. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 1995 Jan 13; 270(2):815-22. Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, Abraham RT. PMID: 7822316.
      View in: PubMed   Mentions: 310     Fields:    Translation:HumansAnimalsCells
    160. Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res. 1995; 1:53-71. Wiederrecht GJ, Sabers CJ, Brunn GJ, Martin MM, Dumont FJ, Abraham RT. PMID: 9552353.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    161. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol Cell. 1995; 83(2-3):105-20. Abraham RT, Acquarone M, Andersen A, Asensi A, Bellé R, Berger F, Bergounioux C, Brunn G, Buquet-Fagot C, Fagot D, et al. PMID: 7549905.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    162. Tyrosine phosphorylation and inositol phosphate production: are early events in human eosinophil activation stimulated by immobilized secretory IgA and IgG? J Allergy Clin Immunol. 1994 Dec; 94(6 Pt 2):1272-81. Kita H, Kato M, Gleich GJ, Abraham RT. PMID: 7798568.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    163. A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors. Anticancer Res. 1994 Nov-Dec; 14(6B):2425-8. Frew T, Powis G, Berggren M, Abraham RT, Ashendel CL, Zalkow LH, Hudson C, Qazia S, Gruszecka-Kowalik E, Merriman R, et al. PMID: 7872663.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    164. Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. J Exp Med. 1994 Oct 01; 180(4):1427-35. Bonnema JD, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ. PMID: 7931075; PMCID: PMC2191702.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    165. A multisample assay for inhibitors of phosphatidylinositol phospholipase C: identification of naturally occurring peptide inhibitors with antiproliferative activity. Anticancer Drug Des. 1994 Aug; 9(4):353-61. Hill SR, Bonjouklian R, Powis G, Abraham RT, Ashendel CL, Zalkow LH. PMID: 7916901.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    166. The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line. J Exp Med. 1994 Jun 01; 179(6):1799-808. Karnitz LM, Sutor SL, Abraham RT. PMID: 7515100; PMCID: PMC2191517.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    167. Cytokine-enhanced NK cell-mediated cytotoxicity. Positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J Immunol. 1994 Mar 01; 152(5):2098-104. Bonnema JD, Rivlin KA, Ting AT, Schoon RA, Abraham RT, Leibson PJ. PMID: 7907631.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    168. Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues. Cancer Chemother Pharmacol. 1994; 34(4):344-50. Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Grindey GB, Bonjouklian R. PMID: 8033301.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    169. Proximal signals and the control of S-phase entry in interleukin-2-stimulated T lymphocytes. Adv Exp Med Biol. 1994; 365:197-210. Abraham RT, Karnitz LM, Burns LA, Brunn GJ. PMID: 7887304.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    170. Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes. J Biol Chem. 1993 Oct 25; 268(30):22737-45. Morice WG, Wiederrecht G, Brunn GJ, Siekierka JJ, Abraham RT. PMID: 8226784.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    171. Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes. J Biol Chem. 1993 Aug 25; 268(24):17659-61. Burns LA, Karnitz LM, Sutor SL, Abraham RT. PMID: 7688728.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    172. A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell. J Biol Chem. 1993 May 25; 268(15):11119-24. Lutz MP, Sutor SL, Abraham RT, Miller LJ. PMID: 7684371.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    173. Inhibition of protein tyrosine phosphatase by the antitumor agent gallium nitrate. Cancer Res. 1993 Apr 15; 53(8):1862-6. Berggren MM, Burns LA, Abraham RT, Powis G. PMID: 8467506.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    174. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J Biol Chem. 1993 Mar 15; 268(8):5886-93. Secrist JP, Burns LA, Karnitz L, Koretzky GA, Abraham RT. PMID: 8383678.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    175. Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes. J Biol Chem. 1993 Feb 15; 268(5):3734-8. Morice WG, Brunn GJ, Wiederrecht G, Siekierka JJ, Abraham RT. PMID: 8429048.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    176. Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells. J Exp Med. 1992 Dec 01; 176(6):1751-5. Ting AT, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ. PMID: 1281218; PMCID: PMC2119449.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    177. Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis. J Biol Chem. 1992 Nov 25; 267(33):23957-62. Ting AT, Schoon RA, Abraham RT, Leibson PJ. PMID: 1429733.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    178. Interleukin-2 signal transduction in human NK cells: multisite phosphorylation and activation of the tyrosine kinase p56lck. J Leukoc Biol. 1992 Nov; 52(5):565-71. Einspahr KJ, Abraham RT, Dick CJ, Leibson PJ. PMID: 1385559.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    179. Signal transduction through the T-cell antigen receptor. Trends Biochem Sci. 1992 Oct; 17(10):434-8. Abraham RT, Karnitz LM, Secrist JP, Leibson PJ. PMID: 1455512.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    180. Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol Cell Biol. 1992 Oct; 12(10):4521-30. Karnitz L, Sutor SL, Torigoe T, Reed JC, Bell MP, McKean DJ, Leibson PJ, Abraham RT. PMID: 1406641; PMCID: PMC360378.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    181. Condensed tannin promotes the release of arachidonic acid from rabbit resident alveolar macrophages. Am J Respir Cell Mol Biol. 1992 Aug; 7(2):172-81. Kreofsky T, Schlager JW, Vuk-Pavlovic Z, Abraham RT, Rohrbach MS. PMID: 1497906.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    182. Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation. J Immunol. 1991 Nov 15; 147(10):3466-73. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT. PMID: 1719078.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    183. Fc gamma receptor signal transduction in natural killer cells. Coupling to phospholipase C via a G protein-independent, but tyrosine kinase-dependent pathway. J Immunol. 1991 Nov 01; 147(9):3122-7. Ting AT, Einspahr KJ, Abraham RT, Leibson PJ. PMID: 1833464.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    184. Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes. Mol Cell Biol. 1991 Sep; 11(9):4431-40. Augustine JA, Sutor SL, Abraham RT. PMID: 1652056; PMCID: PMC361306.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    185. Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6279-83. Einspahr KJ, Abraham RT, Binstadt BA, Uehara Y, Leibson PJ. PMID: 2068107; PMCID: PMC52066.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    186. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1. J Biol Chem. 1991 Jul 05; 266(19):12135-9. Secrist JP, Karnitz L, Abraham RT. PMID: 2061301.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    187. Defective T-lymphocyte signal transduction and function in leukocyte adhesion deficiency. J Clin Immunol. 1991 Jul; 11(4):175-83. Voss LM, Abraham RT, Rhodes KH, Schoon RA, Leibson PJ. PMID: 1918265.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    188. Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism. J Immunol. 1991 May 01; 146(9):2889-97. Augustine JA, Secrist JP, Daniels JK, Leibson PJ, Abraham RT. PMID: 1707924.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    189. Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate. J Immunol. 1991 Apr 15; 146(8):2712-8. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT. PMID: 1707917.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    190. Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine. J Biol Chem. 1990 Nov 25; 265(33):20394-400. Secrist JP, Sehgal I, Powis G, Abraham RT. PMID: 2173705.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    191. Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells. J Immunol. 1990 Sep 01; 145(5):1490-7. Einspahr KJ, Abraham RT, Dick CJ, Leibson PJ. PMID: 1696599.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    192. Transmembrane signaling during natural killer cell-mediated cytotoxicity. Regulation by protein kinase C activation. J Immunol. 1990 Sep 01; 145(5):1498-504. Leibson PJ, Midthun DE, Windebank KP, Abraham RT. PMID: 2166762.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    193. Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells. Biochim Biophys Acta. 1990 May 02; 1052(2):313-22. Augustine JA, Schlager JW, Abraham RT. PMID: 2334739.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    194. Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression. J Immunol. 1990 Mar 01; 144(5):1767-76. Ruegemer JJ, Ho SN, Augustine JA, Schlager JW, Bell MP, McKean DJ, Abraham RT. PMID: 2407783.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    195. Doxorubicin blocks the increase in intracellular Ca++, part of a second messenger system in N1E-115 murine neuroblastoma cells. J Pharmacol Exp Ther. 1990 Mar; 252(3):979-83. Oakes SG, Schlager JJ, Santone KS, Abraham RT, Powis G. PMID: 2319480.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    196. Differential responsiveness to phorbol esters correlates with differential expression of protein kinase C in KG-1 and KG-1a human myeloid leukemia cells. Biochim Biophys Acta. 1989 Sep 04; 1013(1):47-54. Hooper WC, Abraham RT, Ashendel CL, Woloschak GE. PMID: 2790038.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    197. Signal transduction mechanisms in human natural killer cells mediating antitumor immunity. Haematol Blood Transfus. 1989; 32:281-3. Leibson PJ, Windebank KP, Barna TJ, Abraham RT. PMID: 2560445.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    198. Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP. J Immunol. 1988 Dec 01; 141(11):3951-7. Windebank KP, Abraham RT, Powis G, Olsen RA, Barna TJ, Leibson PJ. PMID: 2846696.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    199. Inhibition of T-cell antigen receptor-mediated transmembrane signaling by protein kinase C activation. Mol Cell Biol. 1988 Dec; 8(12):5448-58. Abraham RT, Ho SN, Barna TJ, Rusovick KM, McKean DJ. PMID: 2977423; PMCID: PMC365648.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    200. Interleukin 1-mediated activation of interleukin 4 (IL 4)-producing T lymphocytes. Proliferation by IL 4-dependent and IL 4-independent mechanisms. J Immunol. 1987 Sep 01; 139(5):1532-40. Ho SN, Abraham RT, Nilson A, Handwerger BS, McKean DJ. PMID: 3114369.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    201. Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism. J Biol Chem. 1987 Feb 25; 262(6):2719-28. Abraham RT, Ho SN, Barna TJ, McKean DJ. PMID: 3029093.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    202. Stimulation of arachidonic acid release and eicosanoid biosynthesis in an interleukin 2-dependent T cell line. J Immunopharmacol. 1986; 8(2):165-204. Abraham RT, McKinney MM, Forray C, Shipley GD, Handwerger BS. PMID: 3088127.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    203. Influence of hepatic oxidative metabolism on the immunosuppressive activities of 6-thiopurines. J Pharmacol Exp Ther. 1985 Sep; 234(3):670-6. Abraham RT, Benson LM, Jardine I. PMID: 3162017.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    204. Synthesis and pH-dependent stability of purine-6-sulfenic acid, a putative reactive metabolite of 6-thiopurine. J Med Chem. 1983 Oct; 26(10):1523-6. Abraham RT, Benson LM, Jardine I. PMID: 6684689.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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