Nicholas Wettersten

Title(s)Assistant Professor Of Clinical, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-6122-1152 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, San Diego, CA06/2018Advanced Heart Failure
    University of California, San Diego, San Diego, CA06/2017Cardiology
    University of California, Davis, Sacramento, CA06/2014Internal Medicine
    University of California, Davis, Sacramento, CAMD06/2011Medicine
    University of California, Davis, Davis, CABS09/2007Biochemistry
    Collapse Awards and Honors
    University of California, San Diego2020Medicine 401 Excellence in Teaching Award
    University of California, San Diego2020Schulman Award for Outstanding Research in Cardiology
    University of California, San Diego2019Cardiology Fellowship Teaching Award
    California American College of Cardiology2017 Excellence in Cardiology Fellowship Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Discriminating Causes of Creatinine Change in Acute Heart Failure
    United States Department of Veterans Affairs Clinical Sciences R&D Service IK2 CX002105Oct 1, 2020 - Sep 30, 2025
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis. Am J Cardiol. 2023 Apr 20; 196:11-18. Wettersten N, Katz R, Greenberg JH, Gutierrez OM, Lima JAC, Sarnak MJ, Schrauben S, Deo R, Bonventre J, Vasan RS, Kimmel PL, Shlipak M, Ix JH. PMID: 37086700.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Implications of worsening renal function before hospitalization for acute heart failure. ESC Heart Fail. 2022 Nov 03. Wettersten N, Duff S, Horiuchi Y, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Maisel A, Murray PT, Ix JH. PMID: 36325747.
      View in: PubMed   Mentions:    Fields:    
    3. Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure. J Card Fail. 2023 03; 29(3):269-277. Horiuchi YU, Wettersten N, VAN Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Duff S, Maisel A, Murray PT. PMID: 36332898.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Growth hormone concentration and risk of all-cause and cardiovascular mortality: The REasons for Geographic And Racial Disparities in Stroke (REGARDS) study. Atherosclerosis. 2022 10; 359:20-26. Wettersten N, Mital R, Cushman M, Howard G, Judd SE, Howard VJ, Safford MM, Hartmann O, Bergmann A, Struck J, Maisel A. PMID: 36155327.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Diuretic Resistance-A Key to Identifying Clinically Significant Worsening Renal Function in Heart Failure? Mayo Clin Proc. 2022 09; 97(9):1598-1600. Wettersten N, Duff S, Murray PT. PMID: 36058571.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Kidney Function Specific Reference Limits for N-terminal Pro Brain Natriuretic Peptide and High Sensitivity Troponin T: The Systolic Blood Pressure Intervention Trial. Kidney Med. 2022 Sep; 4(9):100517. Bansal N, Katz R, Seliger S, deFilippi C, Wettersten N, Zelnick LR, Berry JD, de Lemos JA, Christenson R, Killeen AA, Shlipak MG, Ix JH. PMID: 36147204; PMCID: PMC9485592.
      View in: PubMed   Mentions:
    7. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coron Artery Dis. 2022 08 01; 33(5):376-384. Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. PMID: 35880560.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Decongestion, kidney injury and prognosis in patients with acute heart failure. Int J Cardiol. 2022 May 01; 354:29-37. Horiuchi Y, Wettersten N, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Duff S, Maisel A, Murray PT. PMID: 35202737.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Urinary Biomarkers and Kidney Outcomes: Impact of Indexing Versus Adjusting for Urinary Creatinine. Kidney Med. 2021 Jul-Aug; 3(4):546-554.e1. Wettersten N, Katz R, Shlipak MG, Scherzer R, Waikar SS, Ix JH, Estrella MM. PMID: 34401722; PMCID: PMC8350828.
      View in: PubMed   Mentions: 5  
    10. Decongestion discriminates risk for one-year mortality in patients with improving renal function in acute heart failure. Eur J Heart Fail. 2021 07; 23(7):1122-1130. Wettersten N, Horiuchi Y, van Veldhuisen DJ, Ix JH, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, Duff S, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Maisel A, Murray PT. PMID: 33788989.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Kidney Function Following Left Ventricular Assist Device Implantation: An Observational Cohort Study. Kidney Med. 2021 May-Jun; 3(3):378-385.e1. Wettersten N, Estrella M, Brambatti M, Horiuchi Y, Adler E, Pretorius V, Murray PT, Shlipak M, Ix JH. PMID: 34136784; PMCID: PMC8178473.
      View in: PubMed   Mentions: 4  
    12. Advancements in biomarkers for cardiovascular disease: diagnosis, prognosis, and therapy. Fac Rev. 2021; 10:34. Wettersten N, Horiuchi Y, Maisel A. PMID: 33977287; PMCID: PMC8103908.
      View in: PubMed   Mentions: 2  
    13. Response by Horiuchi et al to Letter Regarding Article, "Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction". Circulation. 2021 02 23; 143(8):e252-e253. Horiuchi Y, Wettersten N, Maisel A. PMID: 33617307.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Relation of Decongestion and Time to Diuretics to Biomarker Changes and Outcomes in Acute Heart Failure. Am J Cardiol. 2021 05 15; 147:70-79. Horiuchi Y, Wettersten N, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Maisel A, Murray PT. PMID: 33617811.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Biomarkers in Acute Heart Failure: Diagnosis, Prognosis, and Treatment. Int J Heart Fail. 2021 Apr; 3(2):81-105. Wettersten N. PMID: 36262882; PMCID: PMC9536694.
      View in: PubMed   Mentions: 4  
    16. Potential Utility of Cardiorenal Biomarkers for Prediction and Prognostication of Worsening Renal Function in Acute Heart Failure. J Card Fail. 2021 05; 27(5):533-541. Horiuchi YU, Wettersten N, Veldhuisen DJV, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDONALD K, Mahon N, Nuñez J, Briguori C, Passino C, Maisel A, Murray PT. PMID: 33296713.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Pro-neurotensin/neuromedin N and risk of ischemic stroke: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Vasc Med. 2020 12; 25(6):534-540. Nicoli CD, Wettersten N, Judd SE, Howard G, Howard VJ, Struck J, Cushman M. PMID: 33089749.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction. Circulation. 2020 10 20; 142(16):1532-1544. Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. PMID: 32820656.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    19. Short-term prognostic implications of serum and urine neutrophil gelatinase-associated lipocalin in acute heart failure: findings from the AKINESIS study. Eur J Heart Fail. 2020 02; 22(2):251-263. Wettersten N, Horiuchi Y, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Maisel A, Murray PT. PMID: 31863682.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Aging: Not for the Faint of Heart. JACC Heart Fail. 2019 12; 7(12):1066-1068. Wettersten N. PMID: 31779929.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Implantable cardioverter-defibrillator therapy in patients with left ventricular assist devices: a shocking tale of survival. Eur J Heart Fail. 2020 01; 22(1):29-31. Ho G, Wettersten N, Greenberg B. PMID: 31769111.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure. Eur J Heart Fail. 2019 12; 21(12):1553-1560. Wettersten N, Horiuchi Y, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Murray PT, Maisel A. PMID: 31769140.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    23. Effect on Survival of Concurrent Hemoconcentration and Increase in Creatinine During Treatment of Acute Decompensated Heart Failure. Am J Cardiol. 2019 12 01; 124(11):1707-1711. Griffin M, Rao VS, Fleming J, Raghavendra P, Turner J, Mahoney D, Wettersten N, Maisel A, Ivey-Miranda JB, Inker L, Tang WHW, Wilson FP, Testani JM. PMID: 31601358; PMCID: PMC6959849.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    24. Utility of Urine Neutrophil Gelatinase-Associated Lipocalin for Worsening Renal Function during Hospitalization for Acute Heart Failure: Primary Findings of the Urine N-gal Acute Kidney Injury N-gal Evaluation of Symptomatic Heart Failure Study (AKINESIS). J Card Fail. 2019 Aug; 25(8):654-665. Murray PT, Wettersten N, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Horiuchi Y, Clopton P, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, NuÑez J, Briguori C, Passino C, Maisel A. PMID: 31128242.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    25. Cardiorenal Syndrome: Pathophysiology. Cardiol Clin. 2019 Aug; 37(3):251-265. Kumar U, Wettersten N, Garimella PS. PMID: 31279419; PMCID: PMC6658134.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    26. Hypertrabeculation as a Noncompaction Phenotype in Dilated Cardiomyopathy Defined by Contrast Echocardiography. JACC Cardiovasc Imaging. 2019 07; 12(7 Pt 1):1287-1288. Nishimura M, Igata S, Wong DJ, Wettersten N, Kahn AM, Raisinghani A, Blanchard DG, Strachan M, DeMaria AN. PMID: 30878434.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Biomarker developments in heart failure: 2016 and beyond. Curr Opin Cardiol. 2019 03; 34(2):218-224. Wettersten N, Maisel AS. PMID: 30633074.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Successful heart-kidney transplantation from a Hepatitis C viremic donor to negative recipient: One year of follow-up. Transpl Infect Dis. 2019 Feb; 21(1):e13002. Wettersten N, Tran H, Mekeel K, Pretorius V, Adler E, Aslam S. PMID: 30222242.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. Toward Precision Medicine in the Cardiorenal Syndrome. Adv Chronic Kidney Dis. 2018 09; 25(5):418-424. Wettersten N, Maisel AS, Cruz DN. PMID: 30309459.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (from the Reasons for Geographic and Racial Differences in Stroke Study). Am J Cardiol. 2018 07 01; 122(1):26-32. Wettersten N, Cushman M, Howard VJ, Hartmann O, Filippatos G, Beri N, Clopton P, Howard G, Safford MM, Judd SE, Bergmann A, Struck J, Maisel AS. PMID: 29866581; PMCID: PMC7856682.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Natriuretic Peptides in Heart Failure: Atrial and B-type Natriuretic Peptides. Heart Fail Clin. 2018 Jan; 14(1):13-25. Maisel AS, Duran JM, Wettersten N. PMID: 29153197.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    32. Urinary biomarkers may provide prognostic information for subclinical acute kidney injury after cardiac surgery. J Thorac Cardiovasc Surg. 2018 06; 155(6):2441-2452.e13. Albert C, Albert A, Kube J, Bellomo R, Wettersten N, Kuppe H, Westphal S, Haase M, Haase-Fielitz A. PMID: 29366580.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    33. Acute right heart failure caused by tacrolimus after renal transplantation: Serial observation by speckle tracking and Doppler echocardiography. Echocardiography. 2017 Nov; 34(11):1730-1732. Igata S, Wettersten N, Wong DJ, Sabet A, DeMaria AN. PMID: 29178293.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Mending the Soul When the Heart Is Broken. J Am Coll Cardiol. 2017 07 18; 70(3):342-343. Adler ED, Wettersten N. PMID: 28705315.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Necessity of hospitalization and stress testing in low risk chest pain patients. Am J Emerg Med. 2017 Feb; 35(2):274-280. Beri N, Marston NA, Daniels LB, Nowak RM, Schreiber D, Mueller C, Jaffe A, Diercks DB, Wettersten N, DeFilippi C, Peacock WF, Limkakeng AT, Anand I, McCord J, Hollander JE, Wu AHB, Apple FS, Nagurney JT, Berardi C, Cannon CM, Clopton P, Neath SX, Christenson RH, Hogan C, Vilke G, Maisel A. PMID: 27847253.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Neutrophil Gelatinase-Associated Lipocalin for Acute Kidney Injury During Acute Heart Failure Hospitalizations: The AKINESIS Study. J Am Coll Cardiol. 2016 09 27; 68(13):1420-1431. Maisel AS, Wettersten N, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müller GA, Birkhahn R, Clopton P, Taub P, Vilke GM, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Murray PT. PMID: 27659464.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    37. Biomarkers for Heart Failure: An Update for Practitioners of Internal Medicine. Am J Med. 2016 Jun; 129(6):560-7. Wettersten N, Maisel AS. PMID: 26844635.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    38. Role of Cardiac Troponin Levels in Acute Heart Failure. Card Fail Rev. 2015 Oct; 1(2):102-106. Wettersten N, Maisel A. PMID: 28785441; PMCID: PMC5491037.
      View in: PubMed   Mentions: 26  
    39. Not Simply Sinus Tachycardia. Am J Med. 2015 Sep; 128(9):e13-4. Wettersten N, Fan D, Hsia HH. PMID: 26007675.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    40. Hold the heparin. Crit Pathw Cardiol. 2013 Mar; 12(1):31-2. Wettersten N, Amsterdam E. PMID: 23411606.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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