Loren Looger

Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis. Ann Rheum Dis. 2024 Jun 12; 83(7):879-888. Singh MK, Rallabandi HR, Zhou XJ, Qi YY, Zhao ZZ, Gan T, Zhang H, Looger LL, Nath SK. PMID: 38373841; PMCID: PMC11168881.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state. Nat Commun. 2024 Apr 08; 15(1):3039. Gau YA, Hsu ET, Cha RJ, Pak RW, Looger LL, Kang JU, Bergles DE. PMID: 38589390; PMCID: PMC11002016.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. A Multilayered Post-Genome-Wide Association Study Analysis Pipeline Defines Functional Variants and Target Genes for Systemic Lupus Erythematosus. Arthritis Rheumatol. 2024 Jul; 76(7):1071-1084. Fazel-Najafabadi M, Looger LL, Rallabandi HR, Nath SK. PMID: 38369936; PMCID: PMC11213670.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Extracellular glutamate and GABA transients at the transition from interictal spiking to seizures. Brain. 2024 03 01; 147(3):1011-1024. Shimoda Y, Leite M, Graham RT, Marvin JS, Hasseman J, Kolb I, Looger LL, Magloire V, Kullmann DM. PMID: 37787057; PMCID: PMC10907087.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak-Keller-Segel chemotaxis model. Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3):e2309251121. Phan TV, Mattingly HH, Vo L, Marvin JS, Looger LL, Emonet T. PMID: 38194458; PMCID: PMC10801886.
      View in: PubMed   Mentions: 1     Fields:    
    6. A Non-Coding Variant in SLC15A4 Modulates Enhancer Activity and Lysosomal Deacidification Linked to Lupus Susceptibility. Front Lupus. 2023; 1. Singh MK, Maiti GP, Reddy-Rallabandi H, Fazel-Najafabadi M, Looger LL, Nath SK. PMID: 38317862; PMCID: PMC10843804.
      View in: PubMed   Mentions:
    7. A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE). medRxiv. 2023 Sep 29. Fazel-Najafabadi M, Looger LL, Reddy-Rallabandi H, Nath SK. PMID: 37066327; PMCID: PMC10104240.
      View in: PubMed   Mentions:
    8. A Non-Coding Variant in SLC15A4 Modulates Enhancer Activity and Lysosomal Deacidification Linked to Lupus Susceptibility. bioRxiv. 2023 Sep 02. Singh MK, Maiti GP, Reddy-Rallabandi H, Fazel-Najafabadi M, Looger LL, Nath SK. PMID: 37546883; PMCID: PMC10402135.
      View in: PubMed   Mentions:
    9. Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak-Keller-Segel chemotaxis model. bioRxiv. 2023 Jun 05. Phan TV, Mattingly HH, Vo L, Marvin JS, Looger LL, Emonet T. PMID: 37333331; PMCID: PMC10274659.
      View in: PubMed   Mentions:
    10. Multicore fiber optic imaging reveals that astrocyte calcium activity in the cerebral cortex is modulated by internal motivational state. bioRxiv. 2023 May 18. Gau YA, Hsu E, Cha J, Pak RW, Looger LL, Kang JU, Bergles DE. PMID: 37292710; PMCID: PMC10245653.
      View in: PubMed   Mentions:
    11. Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission. Nat Methods. 2023 Jun; 20(6):925-934. Aggarwal A, Liu R, Chen Y, Ralowicz AJ, Bergerson SJ, Tomaska F, Mohar B, Hanson TL, Hasseman JP, Reep D, Tsegaye G, Yao P, Ji X, Kloos M, Walpita D, Patel R, Mohr MA, Tillberg PW, GENIE Project Team, Looger LL, Marvin JS, Hoppa MB, Konnerth A, Kleinfeld D, Schreiter ER, Podgorski K. PMID: 37142767; PMCID: PMC10250197.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    12. Fast and sensitive GCaMP calcium indicators for imaging neural populations. Nature. 2023 03; 615(7954):884-891. Zhang Y, Rózsa M, Liang Y, Bushey D, Wei Z, Zheng J, Reep D, Broussard GJ, Tsang A, Tsegaye G, Narayan S, Obara CJ, Lim JX, Patel R, Zhang R, Ahrens MB, Turner GC, Wang SS, Korff WL, Schreiter ER, Svoboda K, Hasseman JP, Kolb I, Looger LL. PMID: 36922596; PMCID: PMC10060165.
      View in: PubMed   Mentions: 100     Fields:    Translation:Cells
    13. Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network. Curr Biol. 2023 04 10; 33(7):1249-1264.e7. Magloire V, Savtchenko LP, Jensen TP, Sylantyev S, Kopach O, Cole N, Tyurikova O, Kullmann DM, Walker MC, Marvin JS, Looger LL, Hasseman JP, Kolb I, Pavlov I, Rusakov DA. PMID: 36921605; PMCID: PMC10615848.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    14. Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane. J Neurosci. 2023 03 29; 43(13):2222-2241. Nichols AL, Blumenfeld Z, Luebbert L, Knox HJ, Muthusamy AK, Marvin JS, Kim CH, Grant SN, Walton DP, Cohen BN, Hammar R, Looger L, Artursson P, Dougherty DA, Lester HA. PMID: 36868853; PMCID: PMC10072302.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Fast and sensitive GCaMP calcium indicators for neuronal imaging. J Physiol. 2023 Feb 22. Zhang Y, Looger LL. PMID: 36811153.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    16. Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife. 2022 Dec 15; 11. Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AEM, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, Looger LL, Gallagher T, Rees DC, Lester HA. PMID: 36520038.
      View in: PubMed   Mentions:    Fields:    
    17. Ketamine triggers a switch in excitatory neuronal activity across neocortex. Nat Neurosci. 2023 01; 26(1):39-52. Cichon J, Wasilczuk AZ, Looger LL, Contreras D, Kelz MB, Proekt A. PMID: 36424433; PMCID: PMC10823523.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    18. Fluorescence Screens for Identifying Central Nervous System-Acting Drug-Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics. Bio Protoc. 2022 Nov 20; 12(22). Beatty ZG, Muthusamy AK, Unger EK, Dougherty DA, Tian L, Looger LL, Shivange AV, Bera K, Lester HA, Nichols AL. PMID: 36532688; PMCID: PMC9724018.
      View in: PubMed   Mentions: 1  
    19. Chemically stable fluorescent proteins for advanced microscopy. Nat Methods. 2022 Dec; 19(12):1612-1621. Campbell BC, Paez-Segala MG, Looger LL, Petsko GA, Liu CF. PMID: 36344833; PMCID: PMC9718679.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    20. Genome-wide association study for systemic lupus erythematosus in an egyptian population. Front Genet. 2022; 13:948505. Elghzaly AA, Sun C, Looger LL, Hirose M, Salama M, Khalil NM, Behiry ME, Hegazy MT, Hussein MA, Salem MN, Eltoraby E, Tawhid Z, Alwasefy M, Allam W, El-Shiekh I, Elserafy M, Abdelnaser A, Hashish S, Shebl N, Shahba AA, Elgirby A, Hassab A, Refay K, El-Touchy HM, Youssef A, Shabacy F, Hashim AA, Abdelzaher A, Alshebini E, Fayez D, El-Bakry SA, Elzohri MH, Abdelsalam EN, El-Khamisy SF, Ibrahim S, Ragab G, Nath SK. PMID: 36324510; PMCID: PMC9619055.
      View in: PubMed   Mentions: 3  
    21. Many dissimilar NusG protein domains switch between α-helix and β-sheet folds. Nat Commun. 2022 07 01; 13(1):3802. Porter LL, Kim AK, Rimal S, Looger LL, Majumdar A, Mensh BD, Starich MR, Strub MP. PMID: 35778397; PMCID: PMC9247905.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    22. Discovery and Functional Characterization of Two Regulatory Variants Underlying Lupus Susceptibility at 2p13.1. Genes (Basel). 2022 06 05; 13(6). Fazel-Najafabadi M, Rallabandi HR, Singh MK, Maiti GP, Morris J, Looger LL, Nath SK. PMID: 35741778; PMCID: PMC9222795.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids. J Am Chem Soc. 2022 05 18; 144(19):8480-8486. Muthusamy AK, Kim CH, Virgil SC, Knox HJ, Marvin JS, Nichols AL, Cohen BN, Dougherty DA, Looger LL, Lester HA. PMID: 35446570; PMCID: PMC9121368.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife. 2022 01 04; 11. Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AEM, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, Looger LL, Gallagher T, Rees DC, Lester HA. PMID: 34982029; PMCID: PMC8820738.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    25. Lupus Susceptibility Region Containing CDKN1B rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis. Arthritis Rheumatol. 2021 12; 73(12):2303-2313. Singh B, Maiti GP, Zhou X, Fazel-Najafabadi M, Bae SC, Sun C, Terao C, Okada Y, Heng Chua K, Kochi Y, Guthridge JM, Zhang H, Weirauch M, James JA, Harley JB, Varshney GK, Looger LL, Nath SK. PMID: 33982894; PMCID: PMC8589926.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. A sequence-based method for predicting extant fold switchers that undergo α-helix ↔ β-strand transitions. Biopolymers. 2021 Oct; 112(10):e23471. Mishra S, Looger LL, Porter LL. PMID: 34498740; PMCID: PMC8545793.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    27. In vivo glucose imaging in multiple model organisms with an engineered single-wavelength sensor. Cell Rep. 2021 06 22; 35(12):109284. Keller JP, Marvin JS, Lacin H, Lemon WC, Shea J, Kim S, Lee RT, Koyama M, Keller PJ, Looger LL. PMID: 34161775.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. The functional organization of excitatory synaptic input to place cells. Nat Commun. 2021 06 11; 12(1):3558. Adoff MD, Climer JR, Davoudi H, Marvin JS, Looger LL, Dombeck DA. PMID: 34117238; PMCID: PMC8196201.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    29. Evaluation of multi-color genetically encoded Ca2+ indicators in filamentous fungi. Fungal Genet Biol. 2021 04; 149:103540. Kim HS, Kim JE, Hwangbo A, Akerboom J, Looger LL, Duncan R, Son H, Czymmek KJ, Kang S. PMID: 33607281.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. A high-throughput predictive method for sequence-similar fold switchers. Biopolymers. 2021 Oct; 112(10):e23416. Kim AK, Looger LL, Porter LL. PMID: 33462801; PMCID: PMC8404102.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    31. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. 2020 12 23; 183(7):1986-2002.e26. Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L. PMID: 33333022; PMCID: PMC8025677.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    32. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. Elife. 2020 11 11; 9. Benedetti L, Marvin JS, Falahati H, Guillén-Samander A, Looger LL, De Camilli P. PMID: 33174843; PMCID: PMC7735757.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    33. jYCaMP: an optimized calcium indicator for two-photon imaging at fiber laser wavelengths. Nat Methods. 2020 07; 17(7):694-697. Mohr MA, Bushey D, Aggarwal A, Marvin JS, Kim JJ, Marquez EJ, Liang Y, Patel R, Macklin JJ, Lee CY, Tsang A, Tsegaye G, Ahrens AM, Chen JL, Kim DS, Wong AM, Looger LL, Schreiter ER, Podgorski K. PMID: 32451475; PMCID: PMC7335340.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    34. Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors. Nano Lett. 2020 06 10; 20(6):4073-4083. Zhu PK, Zheng WS, Zhang P, Jing M, Borden PM, Ali F, Guo K, Feng J, Marvin JS, Wang Y, Wan J, Gan L, Kwan AC, Lin L, Looger LL, Li Y, Zhang Y. PMID: 32396366; PMCID: PMC7519949.
      View in: PubMed   Mentions: 13     Fields:    
    35. Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b. Science. 2020 04 17; 368(6488):303-306. Weber C, Zhou Y, Lee JG, Looger LL, Qian G, Ge C, Capel B. PMID: 32299951.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    36. The neuropeptide Drosulfakinin regulates social isolation-induced aggression in Drosophila. J Exp Biol. 2020 Jan 29; 223(Pt 2). Agrawal P, Kao D, Chung P, Looger LL. PMID: 31900346; PMCID: PMC7033730.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    37. Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum. Front Cell Neurosci. 2019; 13:499. Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA. PMID: 31798415; PMCID: PMC6874132.
      View in: PubMed   Mentions: 7  
    38. Voices in methods development. Nat Methods. 2019 10; 16(10):945-951. Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X. PMID: 31562479; PMCID: PMC7075469.
      View in: PubMed   Mentions: 1     Fields:    
    39. Single-Cell Reconstruction of Emerging Population Activity in an Entire Developing Circuit. Cell. 2019 Oct 03; 179(2):355-372.e23. Wan Y, Wei Z, Looger LL, Koyama M, Druckmann S, Keller PJ. PMID: 31564455; PMCID: PMC7055533.
      View in: PubMed   Mentions: 36     Fields:    
    40. Author Correction: Kilohertz frame-rate two-photon tomography. Nat Methods. 2019 Sep; 16(9):932. Kazemipour A, Novak O, Flickinger D, Marvin JS, Abdelfattah AS, King J, Borden PM, Kim JJ, Al-Abdullatif SH, Deal PE, Miller EW, Schreiter ER, Druckmann S, Svoboda K, Looger LL, Podgorski K. PMID: 31388143.
      View in: PubMed   Mentions:    Fields:    
    41. Kilohertz frame-rate two-photon tomography. Nat Methods. 2019 08; 16(8):778-786. Kazemipour A, Novak O, Flickinger D, Marvin JS, Abdelfattah AS, King J, Borden PM, Kim JJ, Al-Abdullatif SH, Deal PE, Miller EW, Schreiter ER, Druckmann S, Svoboda K, Looger LL, Podgorski K. PMID: 31363222; PMCID: PMC6754705.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    42. A genetically encoded fluorescent sensor for in vivo imaging of GABA. Nat Methods. 2019 08; 16(8):763-770. Marvin JS, Shimoda Y, Magloire V, Leite M, Kawashima T, Jensen TP, Kolb I, Knott EL, Novak O, Podgorski K, Leidenheimer NJ, Rusakov DA, Ahrens MB, Kullmann DM, Looger LL. PMID: 31308547.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    43. Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior. Cell. 2019 06 27; 178(1):27-43.e19. Mu Y, Bennett DV, Rubinov M, Narayan S, Yang CT, Tanimoto M, Mensh BD, Looger LL, Ahrens MB. PMID: 31230713.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    44. High-performance calcium sensors for imaging activity in neuronal populations and microcompartments. Nat Methods. 2019 07; 16(7):649-657. Dana H, Sun Y, Mohar B, Hulse BK, Kerlin AM, Hasseman JP, Tsegaye G, Tsang A, Wong A, Patel R, Macklin JJ, Chen Y, Konnerth A, Jayaraman V, Looger LL, Schreiter ER, Svoboda K, Kim DS. PMID: 31209382.
      View in: PubMed   Mentions: 419     Fields:    Translation:AnimalsCells
    45. Inaccurate secondary structure predictions often indicate protein fold switching. Protein Sci. 2019 08; 28(8):1487-1493. Mishra S, Looger LL, Porter LL. PMID: 31148305; PMCID: PMC6635839.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    46. Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor. J Neurosci Res. 2019 08; 97(8):946-960. Díaz-García CM, Lahmann C, Martínez-François JR, Li B, Koveal D, Nathwani N, Rahman M, Keller JP, Marvin JS, Looger LL, Yellen G. PMID: 31106909; PMCID: PMC6565483.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    47. Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility. Front Immunol. 2019; 10:1066. Molineros JE, Singh B, Terao C, Okada Y, Kaplan J, McDaniel B, Akizuki S, Sun C, Webb CF, Looger LL, Nath SK. PMID: 31164884; PMCID: PMC6536009.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    48. Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians. PLoS Genet. 2019 04; 15(4):e1008092. Molineros JE, Looger LL, Kim K, Okada Y, Terao C, Sun C, Zhou XJ, Raj P, Kochi Y, Suzuki A, Akizuki S, Nakabo S, Bang SY, Lee HS, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Zuo X, Yamamoto K, Li QZ, Shen N, Porter LL, Harley JB, Chua KH, Zhang H, Wakeland EK, Tsao BP, Bae SC, Nath SK. PMID: 31022184; PMCID: PMC6504188.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    49. Author Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nat Methods. 2019 Apr; 16(4):351. Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL. PMID: 30820033.
      View in: PubMed   Mentions: 1     Fields:    
    50. Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ. Nat Commun. 2019 03 29; 10(1):1414. Jensen TP, Zheng K, Cole N, Marvin JS, Looger LL, Rusakov DA. PMID: 30926781; PMCID: PMC6441074.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    51. A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP. Nat Commun. 2019 02 12; 10(1):711. Lobas MA, Tao R, Nagai J, Kronschläger MT, Borden PM, Marvin JS, Looger LL, Khakh BS. PMID: 30755613; PMCID: PMC6372613.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    52. Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. J Gen Physiol. 2019 06 03; 151(6):738-757. Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA. PMID: 30718376; PMCID: PMC6571994.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    53. Publisher Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nat Methods. 2019 Feb; 16(2):206. Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Urra Quiroz FJ, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL. PMID: 30602783.
      View in: PubMed   Mentions: 1     Fields:    
    54. Distinct descending motor cortex pathways and their roles in movement. Nature. 2018 11; 563(7729):79-84. Economo MN, Viswanathan S, Tasic B, Bas E, Winnubst J, Menon V, Graybuck LT, Nguyen TN, Smith KA, Yao Z, Wang L, Gerfen CR, Chandrashekar J, Zeng H, Looger LL, Svoboda K. PMID: 30382200.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    55. Shared and distinct transcriptomic cell types across neocortical areas. Nature. 2018 11; 563(7729):72-78. Tasic B, Yao Z, Graybuck LT, Smith KA, Nguyen TN, Bertagnolli D, Goldy J, Garren E, Economo MN, Viswanathan S, Penn O, Bakken T, Menon V, Miller J, Fong O, Hirokawa KE, Lathia K, Rimorin C, Tieu M, Larsen R, Casper T, Barkan E, Kroll M, Parry S, Shapovalova NV, Hirschstein D, Pendergraft J, Sullivan HA, Kim TK, Szafer A, Dee N, Groblewski P, Wickersham I, Cetin A, Harris JA, Levi BP, Sunkin SM, Madisen L, Daigle TL, Looger L, Bernard A, Phillips J, Lein E, Hawrylycz M, Svoboda K, Jones AR, Koch C, Zeng H. PMID: 30382198; PMCID: PMC6456269.
      View in: PubMed   Mentions: 648     Fields:    Translation:AnimalsCells
    56. Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nat Methods. 2018 11; 15(11):936-939. Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SS, DePiero VJ, Borghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL. PMID: 30377363; PMCID: PMC6394230.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    57. Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Cell Rep. 2018 07 10; 24(2):355-365. Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L. PMID: 29996097; PMCID: PMC6631348.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    58. Extant fold-switching proteins are widespread. Proc Natl Acad Sci U S A. 2018 06 05; 115(23):5968-5973. Porter LL, Looger LL. PMID: 29784778; PMCID: PMC6003340.
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    122. A dimorphic pheromone circuit in Drosophila from sensory input to descending output. Nature. 2010 Dec 02; 468(7324):686-90. Ruta V, Datta SR, Vasconcelos ML, Freeland J, Looger LL, Axel R. PMID: 21124455.
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    123. Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature. 2010 Dec 16; 468(7326):921-6. Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN. PMID: 21068723; PMCID: PMC3026603.
      View in: PubMed   Mentions: 230     Fields:    Translation:AnimalsCells
    124. Filtering of visual information in the tectum by an identified neural circuit. Science. 2010 Oct 29; 330(6004):669-73. Del Bene F, Wyart C, Robles E, Tran A, Looger L, Scott EK, Isacoff EY, Baier H. PMID: 21030657; PMCID: PMC3243732.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    125. Functional imaging of hippocampal place cells at cellular resolution during virtual navigation. Nat Neurosci. 2010 Nov; 13(11):1433-40. Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW. PMID: 20890294; PMCID: PMC2967725.
      View in: PubMed   Mentions: 378     Fields:    Translation:AnimalsCells
    126. The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron. 2010 Aug 12; 67(3):373-80. Cheng LE, Song W, Looger LL, Jan LY, Jan YN. PMID: 20696376; PMCID: PMC2933178.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    127. Near-isotropic 3D optical nanoscopy with photon-limited chromophores. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10068-73. Tang J, Akerboom J, Vaziri A, Looger LL, Shank CV. PMID: 20472826; PMCID: PMC2890476.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    128. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods. 2009 Dec; 6(12):875-81. Tian L, Hires SA, Mao T, Huber D, Chiappe ME, Chalasani SH, Petreanu L, Akerboom J, McKinney SA, Schreiter ER, Bargmann CI, Jayaraman V, Svoboda K, Looger LL. PMID: 19898485; PMCID: PMC2858873.
      View in: PubMed   Mentions: 1046     Fields:    Translation:HumansAnimalsCells
    129. Enzyme stabilization by domain insertion into a thermophilic protein. Protein Eng Des Sel. 2009 Oct; 22(10):615-23. Kim CS, Pierre B, Ostermeier M, Looger LL, Kim JR. PMID: 19622545.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    130. A bright and photostable photoconvertible fluorescent protein. Nat Methods. 2009 Feb; 6(2):131-3. McKinney SA, Murphy CS, Hazelwood KL, Davidson MW, Looger LL. PMID: 19169260; PMCID: PMC2745648.
      View in: PubMed   Mentions: 264     Fields:    Translation:HumansAnimalsCells
    131. Crystal structures of the GCaMP calcium sensor reveal the mechanism of fluorescence signal change and aid rational design. J Biol Chem. 2009 Mar 06; 284(10):6455-64. Akerboom J, Rivera JD, Guilbe MM, Malavé EC, Hernandez HH, Tian L, Hires SA, Marvin JS, Looger LL, Schreiter ER. PMID: 19098007; PMCID: PMC2649101.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    132. Reporting neural activity with genetically encoded calcium indicators. Brain Cell Biol. 2008 Aug; 36(1-4):69-86. Hires SA, Tian L, Looger LL. PMID: 18941901; PMCID: PMC2755531.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    133. Crystallization and preliminary X-ray characterization of the genetically encoded fluorescent calcium indicator protein GCaMP2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 01; 64(Pt 7):629-31. Rodríguez Guilbe MM, Alfaro Malavé EC, Akerboom J, Marvin JS, Looger LL, Schreiter ER. PMID: 18607093; PMCID: PMC2443961.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    134. Fluorescence resonance energy transfer sensors for quantitative monitoring of pentose and disaccharide accumulation in bacteria. Biotechnol Biofuels. 2008 Jun 03; 1(1):11. Kaper T, Lager I, Looger LL, Chermak D, Frommer WB. PMID: 18522753; PMCID: PMC2467413.
      View in: PubMed   Mentions: 30  
    135. Retraction. Science. 2008 Feb 01; 319(5863):569. Dwyer MA, Looger LL, Hellinga HW. PMID: 18239106.
      View in: PubMed   Mentions: 4     Fields:    
    136. Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems. Drug Discov Today Dis Models. 2008; 5(1):27-35. Tian L, Looger LL. PMID: 19461949; PMCID: PMC2651031.
      View in: PubMed   Mentions: 7  
    137. Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle. PLoS Biol. 2007 Oct; 5(10):e257. Kaper T, Looger LL, Takanaga H, Platten M, Steinman L, Frommer WB. PMID: 17896864; PMCID: PMC1988858.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    138. A metalloantibody that irreversibly binds a protein antigen. J Biol Chem. 2007 Sep 07; 282(36):26344-53. Trisler K, Looger LL, Sharma V, Baker M, Benson DE, Trauger S, Schultz PG, Smider VV. PMID: 17617633.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    139. A cytosolic trans-activation domain essential for ammonium uptake. Nature. 2007 Mar 08; 446(7132):195-8. Loqué D, Lalonde S, Looger LL, von Wirén N, Frommer WB. PMID: 17293878.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    140. A novel analytical method for in vivo phosphate tracking. FEBS Lett. 2006 Oct 30; 580(25):5885-93. Gu H, Lalonde S, Okumoto S, Looger LL, Scharff-Poulsen AM, Grossman AR, Kossmann J, Jakobsen I, Frommer WB. PMID: 17034793; PMCID: PMC2748124.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    141. Conversion of a putative Agrobacterium sugar-binding protein into a FRET sensor with high selectivity for sucrose. J Biol Chem. 2006 Oct 13; 281(41):30875-83. Lager I, Looger LL, Hilpert M, Lalonde S, Frommer WB. PMID: 16912038.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    142. Construction and optimization of a family of genetically encoded metabolite sensors by semirational protein engineering. Protein Sci. 2005 Sep; 14(9):2304-14. Deuschle K, Okumoto S, Fehr M, Looger LL, Kozhukh L, Frommer WB. PMID: 16131659; PMCID: PMC2253473.
      View in: PubMed   Mentions: 101     Fields:    Translation:Cells
    143. Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8740-5. Okumoto S, Looger LL, Micheva KD, Reimer RJ, Smith SJ, Frommer WB. PMID: 15939876; PMCID: PMC1143584.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    144. Genetically encoded FRET sensors for visualizing metabolites with subcellular resolution in living cells. Plant Physiol. 2005 Jun; 138(2):555-7. Looger LL, Lalonde S, Frommer WB. PMID: 15955913; PMCID: PMC1150369.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    145. Genetically encoded sensors for metabolites. Cytometry A. 2005 Mar; 64(1):3-9. Deuschle K, Fehr M, Hilpert M, Lager I, Lalonde S, Looger LL, Okumoto S, Persson J, Schmidt A, Frommer WB. PMID: 15688353; PMCID: PMC2752217.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    146. Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor. Protein Sci. 2005 Feb; 14(2):284-91. Dattelbaum JD, Looger LL, Benson DE, Sali KM, Thompson RB, Hellinga HW. PMID: 15659363; PMCID: PMC2253422.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    147. Development and use of fluorescent nanosensors for metabolite imaging in living cells. Biochem Soc Trans. 2005 Feb; 33(Pt 1):287-90. Fehr M, Okumoto S, Deuschle K, Lager I, Looger LL, Persson J, Kozhukh L, Lalonde S, Frommer WB. PMID: 15667328.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    148. Computational design of a biologically active enzyme. Science. 2004 Jun 25; 304(5679):1967-71. Dwyer MA, Looger LL, Hellinga HW. PMID: 15218149.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    149. Computational design of receptors for an organophosphate surrogate of the nerve agent soman. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):7907-12. Allert M, Rizk SS, Looger LL, Hellinga HW. PMID: 15148405; PMCID: PMC419530.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    150. Computational design of a Zn2+ receptor that controls bacterial gene expression. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11255-60. Dwyer MA, Looger LL, Hellinga HW. PMID: 14500902; PMCID: PMC208744.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    151. Computational design of receptor and sensor proteins with novel functions. Nature. 2003 May 08; 423(6936):185-90. Looger LL, Dwyer MA, Smith JJ, Hellinga HW. PMID: 12736688.
      View in: PubMed   Mentions: 171     Fields:    Translation:Cells
    152. Control of a biomolecular motor-powered nanodevice with an engineered chemical switch. Nat Mater. 2002 Nov; 1(3):173-7. Liu H, Schmidt JJ, Bachand GD, Rizk SS, Looger LL, Hellinga HW, Montemagno CD. PMID: 12618806.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    153. Construction of a fluorescent biosensor family. Protein Sci. 2002 Nov; 11(11):2655-75. de Lorimier RM, Smith JJ, Dwyer MA, Looger LL, Sali KM, Paavola CD, Rizk SS, Sadigov S, Conrad DW, Loew L, Hellinga HW. PMID: 12381848; PMCID: PMC2373719.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    154. Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics. J Mol Biol. 2001 Mar 16; 307(1):429-45. Looger LL, Hellinga HW. PMID: 11243829.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    155. Computerized in vitro test for chemical toxicity based on Tetrahymena swimming patterns. Chemosphere. 1994 Sep; 29(6):1373-84. Noever DA, Matsos HC, Cronise RJ, Looger LL, Relwani RA, Johnson JU. PMID: 7953473.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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