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Leah Bushin

Title(s)Postdoctoral Scholar, Center for Marine Biotechnology and Biomedecine
SchoolVc-marine Sciences
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound. mBio. 2021 03 16; 12(2). Rued BE, Covington BC, Bushin LB, Szewczyk G, Laczkovich I, Seyedsayamdost MR, Federle MJ. PMID: 33727351.
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    2. Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome. J Am Chem Soc. 2020 09 23; 142(38):16265-16275. Bushin LB, Covington BC, Rued BE, Federle MJ, Seyedsayamdost MR. PMID: 32845143.
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    3. Total Synthesis and Stereochemical Assignment of Streptide. J Am Chem Soc. 2019 10 30; 141(43):17361-17369. Isley NA, Endo Y, Wu ZC, Covington BC, Bushin LB, Seyedsayamdost MR, Boger DL. PMID: 31577142.
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    4. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes. J Am Chem Soc. 2019 10 23; 141(42):16610-16614. Caruso A, Martinie RJ, Bushin LB, Seyedsayamdost MR. PMID: 31596076.
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    5. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019 07 10; 141(27):10610-10615. Clark KA, Bushin LB, Seyedsayamdost MR. PMID: 31246011.
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    6. A genetics-free method for high-throughput discovery of cryptic microbial metabolites. Nat Chem Biol. 2019 02; 15(2):161-168. Xu F, Wu Y, Zhang C, Davis KM, Moon K, Bushin LB, Seyedsayamdost MR. PMID: 30617293.
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    7. Radical Approach to Enzymatic ß-Thioether Bond Formation. J Am Chem Soc. 2019 01 16; 141(2):990-997. Caruso A, Bushin LB, Clark KA, Martinie RJ, Seyedsayamdost MR. PMID: 30521328.
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    8. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018 12 19; 140(50):17674-17684. Bushin LB, Clark KA, Pelczer I, Seyedsayamdost MR. PMID: 30398325.
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    9. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018; 606:439-460. Bushin LB, Seyedsayamdost MR. PMID: 30097102.
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    10. Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. J Am Chem Soc. 2017 07 12; 139(27):9203-9212. Xu F, Nazari B, Moon K, Bushin LB, Seyedsayamdost MR. PMID: 28590725.
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    11. Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2920-E2928. Mao D, Bushin LB, Moon K, Wu Y, Seyedsayamdost MR. PMID: 28320949.
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    12. Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae. ACS Chem Biol. 2017 03 17; 12(3):814-824. Metelev M, Arseniev A, Bushin LB, Kuznedelov K, Artamonova TO, Kondratenko R, Khodorkovskii M, Seyedsayamdost MR, Severinov K. PMID: 28106375.
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    13. Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis. ACS Chem Biol. 2016 08 19; 11(8):2124-30. Okada BK, Wu Y, Mao D, Bushin LB, Seyedsayamdost MR. PMID: 27367535.
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    14. Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink. Nat Chem. 2015 May; 7(5):431-437. Schramma KR, Bushin LB, Seyedsayamdost MR. PMID: 25901822.
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