Andrew Mendiola

Title(s)	Assistant Professor, Pharmacology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

Gladstone Institutes, San Francisco	Postdoc	09/2023	Neuroimmunology
The University of Texas at San Antonio, San Antonio	PhD	05/2017	Neuroimmunology
The University of Texas at San Antonio, San Antonio	MS	08/2013	Biology
The University of Texas at San Antonio, San Antonio	BS	05/2011	Biology

Overview

Interests

Microglia, Neuroinflammation, Neurodegeneration, Genomics, Blood-brain barrier, oxidative stress, fibrinogen, Epigenetics, Neuroimmunology, Alzheimer's disease, multiple sclerosis

Websites

	Mendiola Lab Website
	Department Profile

Research

Research Activities and Funding

Epigenomic regulation of oxidative stress-producing innate immunity in neuroinflammation
NIH K99NS126707Apr 15, 2022 - Mar 31, 2024
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation. J Neuroinflammation. 2024 Apr 15; 21(1):94. Dean T, Mendiola AS, Yan Z, Meza-Acevedo R, Cabriga B, Akassoglou K, Ryu JK. PMID: 38622640; PMCID: PMC11017541.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Humans Animals
Un-BAFFling gray matter pathology in multiple sclerosis. Sci Immunol. 2024 Apr 05; 9(94):eadp4667. Ford-Roshon D, Mendiola AS. PMID: 38579016.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Humans
Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol. 2023 07; 24(7):1173-1187. Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico AR, Ryu JK, Krogan NJ, Akassoglou K. PMID: 37291385; PMCID: PMC10307624.

View in: PubMed Mentions: 29 Fields:
All Allergy and Immunology
Translation:Animals Cells
Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina. Front Immunol. 2023; 14:1130735. Church KA, Rodriguez D, Mendiola AS, Vanegas D, Gutierrez IL, Tamayo I, Amadu A, Velazquez P, Cardona SM, Gyoneva S, Cotleur AC, Ransohoff RM, Kaur T, Cardona AE. PMID: 37033925; PMCID: PMC10077890.

View in: PubMed Mentions: 5 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination. J Neurochem. 2022 09; 162(5):430-443. Mendiola AS, Church KA, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE. PMID: 35560167; PMCID: PMC9427683.

View in: PubMed Mentions: 6 Fields:
Che Chemistry Neu Neurology
Translation:Humans Animals Cells
Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner. ASN Neuro. 2022 Jan-Dec; 14:17590914221131446. Sarker B, Cardona SM, Church KA, Vanegas D, Velazquez P, Rorex C, Rodriguez D, Mendiola AS, Kern TS, Domingo ND, Stephens R, Muzzio IA, Cardona AE. PMID: 36221892; PMCID: PMC9557863.

View in: PubMed Mentions: 6 Fields:
Che Chemistry Neu Neurology
Translation:Humans Animals Cells
BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis. Brain. 2021 09 04; 144(8):2291-2301. Petersen MA, Tognatta R, Meyer-Franke A, Bushong EA, Mendiola AS, Yan Z, Muthusamy A, Merlini M, Meza-Acevedo R, Cabriga B, Zhou Y, Thomas R, Ryu JK, Lassmann H, Ellisman MH, Akassoglou K. PMID: 34426831; PMCID: PMC8418337.

View in: PubMed Mentions: 14 Fields:
Bra Brain Neu Neurology
Translation:Animals Cells
ApoE and immunity in Alzheimer's disease and related tauopathies: Low-density lipoprotein receptor to the rescue. Neuron. 2021 08 04; 109(15):2363-2365. Mendiola AS, Tognatta R, Yan Z, Akassoglou K. PMID: 34352209; PMCID: PMC8546493.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Humans
Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma. Am J Pathol. 2021 03; 191(3):575-583. Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK. PMID: 33608067; PMCID: PMC7919853.

View in: PubMed Mentions: 6 Fields:
Pat Pathology
Translation:Humans Animals Cells
Microglial Gi-dependent dynamics regulate brain network hyperexcitability. Nat Neurosci. 2021 01; 24(1):19-23. Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K. PMID: 33318667; PMCID: PMC8118167.

View in: PubMed Mentions: 59 Fields:
Neu Neurology
Translation:Animals Cells
Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 Sep; 21(9):1135. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Coronado PER, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32661365.

View in: PubMed Mentions: 2 Fields:
All Allergy and Immunology
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594; PMCID: PMC7523413.

View in: PubMed Mentions: 82 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10488-10493. Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. PMID: 31068461; PMCID: PMC6535008.

View in: PubMed Mentions: 27 Fields:
Sci Science
Translation:Humans Animals Cells
Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant. Front Cell Neurosci. 2018; 12:365. Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich SS, Parker-Thornburg J, Soto-Ospina A, Araque P, Ransohoff RM, Cardona AE. PMID: 30386211; PMCID: PMC6199958.

View in: PubMed Mentions: 30
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343; PMCID: PMC6317891.

View in: PubMed Mentions: 104 Fields:
All Allergy and Immunology
Translation:Humans Animals
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804; PMCID: PMC5851281.

View in: PubMed Mentions: 91 Fields:
Neu Neurology
Translation:Animals Cells
The IL-1β phenomena in neuroinflammatory diseases. J Neural Transm (Vienna). 2018 05; 125(5):781-795. Mendiola AS, Cardona AE. PMID: 28534174; PMCID: PMC5699978.

View in: PubMed Mentions: 90 Fields:
Neu Neurology Phy Physiology
Translation:Humans Animals
Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy. Front Cell Neurosci. 2016; 10:303. Mendiola AS, Garza R, Cardona SM, Mythen SA, Lira SA, Akassoglou K, Cardona AE. PMID: 28119571; PMCID: PMC5222852.

View in: PubMed Mentions: 25
Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformans In Vitro Requires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species. Infect Immun. 2016 09; 84(9):2493-504. Hole CR, Leopold Wager CM, Mendiola AS, Wozniak KL, Campuzano A, Lin X, Wormley FL. PMID: 27324480; PMCID: PMC4995896.

View in: PubMed Mentions: 23 Fields:
All Allergy and Immunology Com Communicable Diseases
Translation:Humans Animals Cells
Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina. ASN Neuro. 2015 Sep-Oct; 7(5). Cardona SM, Mendiola AS, Yang YC, Adkins SL, Torres V, Cardona AE. PMID: 26514658; PMCID: PMC4641555.

View in: PubMed Mentions: 42 Fields:
Che Chemistry Neu Neurology
Translation:Animals Cells
The role of microglia in diabetic retinopathy. J Ophthalmol. 2014; 2014:705783. Grigsby JG, Cardona SM, Pouw CE, Muniz A, Mendiola AS, Tsin AT, Allen DM, Cardona AE. PMID: 25258680; PMCID: PMC4166427.

View in: PubMed Mentions: 89