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Amy Pasquinelli

Title(s)Professor, Molecular Biology
SchoolAcademic Aff
Address9500 Gilman Drive #0349
La Jolla CA 92093
Phone858-822-3006
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    Collapse Research 
    Collapse Research Activities and Funding
    Pathways in Biological Sciences Training Program
    NIH/NIGMS T32GM133351Jul 1, 2020 - Jun 30, 2025
    Role: Co-Principal Investigator
    Biogenesis and Function of Regulatory RNAs
    NIH/NIGMS R35GM127012Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Role of miRNA Argonautes in organismal aging
    NIH/NIA R01AG056562Sep 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Role of Argonaute in miRNA biogenesis and function
    NIH/NIGMS R01GM071654Jun 1, 2004 - May 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Auxin-independent depletion of degron-tagged proteins by TIR1. MicroPubl Biol. 2020 Jan 28; 2020. Schiksnis E, Nicholson A, Modena M, Pule M, Arribere J, Pasquinelli A. PMID: 32550513.
      View in: PubMed   Mentions:
    2. Diversification of the Caenorhabditis heat shock response by Helitron transposable elements. Elife. 2019 12 11; 8. Garrigues JM, Tsu BV, Daugherty MD, Pasquinelli AE. PMID: 31825311.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Remodeling of the Caenorhabditis elegans non-coding RNA transcriptome by heat shock. Nucleic Acids Res. 2019 10 10; 47(18):9829-9841. Schreiner WP, Pagliuso DC, Garrigues JM, Chen JS, Aalto AP, Pasquinelli AE. PMID: 31396626.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Todos Santos small RNA symposium. RNA Biol. 2019 11; 16(11):1526-1530. Winkenbach LP, Doser R, Reed KJ, Pasquinelli AE, Phillips CM, Claycomb JM. PMID: 31397621.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. RNA interference may result in unexpected phenotypes in Caenorhabditis elegans. Nucleic Acids Res. 2019 05 07; 47(8):3957-3969. De-Souza EA, Camara H, Salgueiro WG, Moro RP, Knittel TL, Tonon G, Pinto S, Pinca APF, Antebi A, Pasquinelli AE, Massirer KB, Mori MA. PMID: 30838421.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. miRNA Targeting: Growing beyond the Seed. Trends Genet. 2019 03; 35(3):215-222. Chipman LB, Pasquinelli AE. PMID: 30638669.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Tales of Detailed Poly(A) Tails. Trends Cell Biol. 2019 03; 29(3):191-200. Nicholson AL, Pasquinelli AE. PMID: 30503240.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging. PLoS Genet. 2018 06; 14(6):e1007379. Aalto AP, Nicastro IA, Broughton JP, Chipman LB, Schreiner WP, Chen JS, Pasquinelli AE. PMID: 29927939.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. A rADAR defense against RNAi. Genes Dev. 2018 02 01; 32(3-4):199-201. Pasquinelli AE. PMID: 29491134.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Detection of microRNA-Target Interactions by Chimera PCR (ChimP). Methods Mol Biol. 2018; 1823:153-165. Broughton JP, Pasquinelli AE. PMID: 29959680.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Short poly(A) tails are a conserved feature of highly expressed genes. Nat Struct Mol Biol. 2017 Dec; 24(12):1057-1063. Lima SA, Chipman LB, Nicholson AL, Chen YH, Yee BA, Yeo GW, Coller J, Pasquinelli AE. PMID: 29106412.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    12. Pairing beyond the Seed Supports MicroRNA Targeting Specificity. Mol Cell. 2016 10 20; 64(2):320-333. Broughton JP, Lovci MT, Huang JL, Yeo GW, Pasquinelli AE. PMID: 27720646.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    13. A sense-able microRNA. Genes Dev. 2016 09 15; 30(18):2019-2020. Pasquinelli AE. PMID: 27798846.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    14. A tale of two sequences: microRNA-target chimeric reads. Genet Sel Evol. 2016 Apr 04; 48:31. Broughton JP, Pasquinelli AE. PMID: 27044644.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Splicing remodels the let-7 primary microRNA to facilitate Drosha processing in Caenorhabditis elegans. RNA. 2015 Aug; 21(8):1396-403. Mondol V, Ahn BC, Pasquinelli AE. PMID: 26081559.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. MicroRNAs: heralds of the noncoding RNA revolution. RNA. 2015 Apr; 21(4):709-10. Pasquinelli AE. PMID: 25780202.
      View in: PubMed   Mentions: 4     Fields:    
    17. Period homolog LIN-42 regulates miRNA transcription to impact developmental timing. Worm. 2014 Oct-Dec; 3(4):e974453. Van Wynsberghe PM, Pasquinelli AE. PMID: 26435883.
      View in: PubMed   Mentions:
    18. Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes. WormBook. 2014 Jun 24; 1-18. Fonslow BR, Moresco JJ, Tu PG, Aalto AP, Pasquinelli AE, Dillin AG, Yates JR. PMID: 24967700.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    19. The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans. Dev Biol. 2014 Jun 15; 390(2):126-35. Van Wynsberghe PM, Finnegan EF, Stark T, Angelus EP, Homan KE, Yeo GW, Pasquinelli AE. PMID: 24699545.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    20. Identification of miRNAs and their targets in C. elegans. Adv Exp Med Biol. 2014; 825:431-50. Lima SA, Pasquinelli AE. PMID: 25201113.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    21. The primary target of let-7 microRNA. Biochem Soc Trans. 2013 Aug; 41(4):821-4. Pasquinelli AE. PMID: 23863138.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    22. Identifying Argonaute binding sites in Caenorhabditis elegans using iCLIP. Methods. 2013 Sep 15; 63(2):119-25. Broughton JP, Pasquinelli AE. PMID: 23583680.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    23. Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans. PLoS Genet. 2013; 9(3):e1003353. Hunter SE, Finnegan EF, Zisoulis DG, Lovci MT, Melnik-Martinez KV, Yeo GW, Pasquinelli AE. PMID: 23516374.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    24. MicroRNAs that interfere with RNAi. Worm. 2013 Jan 01; 2(1):e21835. Massirer KB, Pasquinelli AE. PMID: 24058860.
      View in: PubMed   Mentions:
    25. Multiple cis-elements and trans-acting factors regulate dynamic spatio-temporal transcription of let-7 in Caenorhabditis elegans. Dev Biol. 2013 Feb 01; 374(1):223-33. Kai ZS, Finnegan EF, Huang S, Pasquinelli AE. PMID: 23201578.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol. 2013 Jan-Feb; 48(1):51-68. Finnegan EF, Pasquinelli AE. PMID: 23163351.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    27. Birthing histone mRNAs by CSR-1 section. EMBO J. 2012 Oct 03; 31(19):3790-1. Pasquinelli AE. PMID: 22960639.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    28. Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature. 2012 Jun 28; 486(7404):541-4. Zisoulis DG, Kai ZS, Chang RK, Pasquinelli AE. PMID: 22722835.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    29. Small non-coding RNAs mount a silent revolution in gene expression. Curr Opin Cell Biol. 2012 Jun; 24(3):333-40. Aalto AP, Pasquinelli AE. PMID: 22464106.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    30. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet. 2012 Mar 13; 13(4):271-82. Pasquinelli AE. PMID: 22411466.
      View in: PubMed   Mentions: 501     Fields:    Translation:Cells
    31. The miR-35-41 family of microRNAs regulates RNAi sensitivity in Caenorhabditis elegans. PLoS Genet. 2012; 8(3):e1002536. Massirer KB, Perez SG, Mondol V, Pasquinelli AE. PMID: 22412382.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    32. A team effort blocks the ribosome in its tracks. Nat Struct Mol Biol. 2012 Feb 03; 19(2):133-4. Pasquinelli AE. PMID: 22301874.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    33. Let's make it happen: the role of let-7 microRNA in development. Curr Top Dev Biol. 2012; 99:1-30. Mondol V, Pasquinelli AE. PMID: 22365733.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    34. LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nat Struct Mol Biol. 2011 Mar; 18(3):302-8. Van Wynsberghe PM, Kai ZS, Massirer KB, Burton VH, Yeo GW, Pasquinelli AE. PMID: 21297634.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    35. Comprehensive identification of miRNA target sites in live animals. Methods Mol Biol. 2011; 732:169-85. Zisoulis DG, Yeo GW, Pasquinelli AE. PMID: 21431713.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    36. Analysis of microRNA expression and function. Methods Cell Biol. 2011; 106:219-252. Van Wynsberghe PM, Chan SP, Slack FJ, Pasquinelli AE. PMID: 22118279.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    37. Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans. Dev Biol. 2010 Dec 15; 348(2):210-21. Bracht JR, Van Wynsberghe PM, Mondol V, Pasquinelli AE. PMID: 20937268.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Molecular biology. Paring miRNAs through pairing. Science. 2010 Jun 18; 328(5985):1494-5. Pasquinelli AE. PMID: 20558697.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    39. A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. Stem Cells Dev. 2010 Jun; 19(6):797-807. Hinton A, Afrikanova I, Wilson M, King CC, Maurer B, Yeo GW, Hayek A, Pasquinelli AE. PMID: 19807270.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    40. MicroRNAs and cancer: a meeting summary of the eponymous Keystone Conference. Epigenetics. 2010 Feb 16; 5(2):164-8. Godshalk SE, Melnik-Martinez KV, Pasquinelli AE, Slack FJ. PMID: 20168081.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    41. A genome wide view of hunchback-like-1 targets. Cell Cycle. 2010 Jan 15; 9(2):230-1. Kai Z, Pasquinelli AE. PMID: 20061795.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    42. Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat Struct Mol Biol. 2010 Feb; 17(2):173-9. Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang TY, Pasquinelli AE, Yeo GW. PMID: 20062054.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    43. MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nat Struct Mol Biol. 2010 Jan; 17(1):5-10. Kai ZS, Pasquinelli AE. PMID: 20051982.
      View in: PubMed   Mentions: 112     Fields:    
    44. Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans. RNA. 2009 Mar; 15(3):400-5. Holtz J, Pasquinelli AE. PMID: 19155321.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    45. Computational prediction and experimental validation of Ciona intestinalis microRNA genes. BMC Genomics. 2007 Nov 29; 8:445. Norden-Krichmar TM, Holtz J, Pasquinelli AE, Gaasterland T. PMID: 18047675.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. MicroRNA silencing through RISC recruitment of eIF6. Nature. 2007 Jun 14; 447(7146):823-8. Chendrimada TP, Finn KJ, Ji X, Baillat D, Gregory RI, Liebhaber SA, Pasquinelli AE, Shiekhattar R. PMID: 17507929.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    47. The evolving role of microRNAs in animal gene expression. Bioessays. 2006 May; 28(5):449-52. Massirer KB, Pasquinelli AE. PMID: 16615087.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    48. Demystifying small RNA pathways. Dev Cell. 2006 Apr; 10(4):419-24. Pasquinelli AE. PMID: 16625708.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    49. Identification and analysis of microRNAs. Genet Eng (N Y). 2006; 27:1-20. Bagga S, Pasquinelli AE. PMID: 16382868.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    50. Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn. 2005 Dec; 234(4):948-60. Lancman JJ, Caruccio NC, Harfe BD, Pasquinelli AE, Schageman JJ, Pertsemlidis A, Fallon JF. PMID: 16245339.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    51. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell. 2005 Aug 26; 122(4):553-63. Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R, Pasquinelli AE. PMID: 16122423.
      View in: PubMed   Mentions: 478     Fields:    Translation:AnimalsCells
    52. MicroRNAs: a developing story. Curr Opin Genet Dev. 2005 Apr; 15(2):200-5. Pasquinelli AE, Hunter S, Bracht J. PMID: 15797203.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    53. Functional genomic analysis of RNA interference in C. elegans. Science. 2005 May 20; 308(5725):1164-7. Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. PMID: 15790806.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    54. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct; 36(10):1079-83. Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. PMID: 15361871.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    55. Trans-splicing and polyadenylation of let-7 microRNA primary transcripts. RNA. 2004 Oct; 10(10):1586-94. Bracht J, Hunter S, Eachus R, Weeks P, Pasquinelli AE. PMID: 15337850.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    56. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evol Dev. 2003 Jul-Aug; 5(4):372-8. Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J. PMID: 12823453.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    57. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003 Jul 01; 259(1):1-8. Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS. PMID: 12812783.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    58. The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell. 2003 May; 4(5):639-50. Lin SY, Johnson SM, Abraham M, Vella MC, Pasquinelli A, Gamberi C, Gottlieb E, Slack FJ. PMID: 12737800.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    59. Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002; 18:495-513. Pasquinelli AE, Ruvkun G. PMID: 12142272.
      View in: PubMed   Mentions: 97     Fields:    Translation:Animals
    60. MicroRNAs: deviants no longer. Trends Genet. 2002 Apr; 18(4):171-3. Pasquinelli AE. PMID: 11932009.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    61. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001 Jul 13; 106(1):23-34. Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. PMID: 11461699.
      View in: PubMed   Mentions: 627     Fields:    Translation:Animals
    62. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 2001 Aug 03; 293(5531):834-8. Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T, Zamore PD. PMID: 11452083.
      View in: PubMed   Mentions: 899     Fields:    Translation:HumansAnimalsCells
    63. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000 Nov 02; 408(6808):86-9. Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. PMID: 11081512.
      View in: PubMed   Mentions: 654     Fields:    Translation:HumansAnimalsCells
    64. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000 Feb 24; 403(6772):901-6. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. PMID: 10706289.
      View in: PubMed   Mentions: 1415     Fields:    Translation:AnimalsCells
    65. Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14394-9. Pasquinelli AE, Powers MA, Lund E, Forbes D, Dahlberg JE. PMID: 9405623.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    66. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. EMBO J. 1997 Dec 15; 16(24):7500-10. Pasquinelli AE, Ernst RK, Lund E, Grimm C, Zapp ML, Rekosh D, Hammarskjöld ML, Dahlberg JE. PMID: 9405378.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    67. Reverse 5' caps in RNAs made in vitro by phage RNA polymerases. RNA. 1995 Nov; 1(9):957-67. Pasquinelli AE, Dahlberg JE, Lund E. PMID: 8548660.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    68. BstUI and DpnII RFLPs at the COL5A1 gene. Hum Mol Genet. 1994 Feb; 3(2):385. Greenspan DS, Pasquinelli AE. PMID: 7911701.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
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