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Alberto Hayek

TitleSenate Emeritus
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0983
La Jolla CA 92093
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    Collapse Research Activities and Funding
    SMALL INSTRUMENTATION GRANT
    NIH/NIDDK S15DK046038Aug 1, 1992 - Jul 31, 1993
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH/NIDDK S15DK044705Aug 1, 1991 - Jul 31, 1992
    Role: Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH/NIDDK S15DK043427Jul 15, 1990 - Jun 30, 1991
    Role: Principal Investigator
    ISLET TRANSPLANTATION IN EXPERIMENTAL DIABETES
    NIH/NIDDK R01DK039087Dec 1, 1988 - Nov 30, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hayek A. Lessons Learned in War. Perm J. 2017; 21. PMID: 28633730.
      View in: PubMed
    2. Hayek A, King CC. Brief review: cell replacement therapies to treat type 1 diabetes mellitus. Clin Diabetes Endocrinol. 2016; 2:4. PMID: 28702240.
      View in: PubMed
    3. Hinton A, Hunter SE, Afrikanova I, Jones GA, Lopez AD, Fogel GB, Hayek A, King CC. sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets. Stem Cells. 2014 Sep; 32(9):2360-72. PMID: 24805944.
      View in: PubMed
    4. Lopez AD, Kayali AG, Hayek A, King CC. Isolation, culture, and imaging of human fetal pancreatic cell clusters. J Vis Exp. 2014 May 18; (87). PMID: 24895054; PMCID: PMC4193289.
    5. Afrikanova I, Kayali A, Lopez A, Hayek A. Is stage-specific embryonic antigen 4 a marker for human ductal stem/progenitor cells? Biores Open Access. 2012 Aug; 1(4):184-91. PMID: 23515456; PMCID: PMC3559232.
    6. Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. Kartogenin: a game-changer in regenerative medicine. Regen Med. 2012 Jul; 7(4):475. PMID: 22993885.
      View in: PubMed
    7. Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. Pumping iron in the brain. Regen Med. 2012 Jul; 7(4):474. PMID: 22993884.
      View in: PubMed
    8. Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. Generation of functional hair follicles from follicle germs in a nude mouse model of organ replacement regenerative therapy. Regen Med. 2012 Jul; 7(4):475-6. PMID: 22993886.
      View in: PubMed
    9. Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. A new factory for insulin-producing cells: the gut? Regen Med. 2012 Jul; 7(4):473. PMID: 22817622.
      View in: PubMed
    10. Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC. The SDF-1a/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells. PLoS One. 2012; 7(6):e38721. PMID: 22761699; PMCID: PMC3382144.
    11. Afrikanova I, Yebra M, Simpkinson M, Xu Y, Hayek A, Montgomery A. Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of ß-cells from human pluripotent stem cells. J Biol Chem. 2011 Oct 14; 286(41):36042-52. PMID: 21852242; PMCID: PMC3195622.
    12. Kaido TJ, Yebra M, Kaneto H, Cirulli V, Hayek A, Montgomery AM. Impact of integrin-matrix interaction and signaling on insulin gene expression and the mesenchymal transition of human beta-cells. J Cell Physiol. 2010 Jul; 224(1):101-11. PMID: 20232313.
      View in: PubMed
    13. Hinton A, Afrikanova I, Wilson M, King CC, Maurer B, Yeo GW, Hayek A, Pasquinelli AE. A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. Stem Cells Dev. 2010 Jun; 19(6):797-807. PMID: 19807270.
      View in: PubMed
    14. Xu Y, Zhu X, Hahm HS, Wei W, Hao E, Hayek A, Ding S. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8129-34. PMID: 20406903; PMCID: PMC2889586.
    15. Li W, Zhou H, Abujarour R, Zhu S, Young Joo J, Lin T, Hao E, Schöler HR, Hayek A, Ding S. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells. 2009 Dec; 27(12):2992-3000. PMID: 19839055; PMCID: PMC3780784.
    16. Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S. A chemical platform for improved induction of human iPSCs. Nat Methods. 2009 Nov; 6(11):805-8. PMID: 19838168; PMCID: PMC3724527.
    17. Bucay N, Yebra M, Cirulli V, Afrikanova I, Kaido T, Hayek A, Montgomery AM. A novel approach for the derivation of putative primordial germ cells and sertoli cells from human embryonic stem cells. Stem Cells. 2009 Jan; 27(1):68-77. PMID: 18845765.
      View in: PubMed
    18. Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H, Ding S. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell. 2009 Jan 09; 4(1):16-9. PMID: 19097958.
      View in: PubMed
    19. King CC, Beattie GM, Lopez AD, Hayek A. Generation of definitive endoderm from human embryonic stem cells cultured in feeder layer-free conditions. Regen Med. 2008 Mar; 3(2):175-80. PMID: 18307401.
      View in: PubMed
    20. Fousteri G, Hayek A, von Herrath M. Stopping diabetes in its tracks: autologous non-myeloablative stem cell transplantation. Regen Med. 2007 Sep; 2(5):845-51. PMID: 17907936.
      View in: PubMed
    21. Kayali AG, Flores LE, Lopez AD, Kutlu B, Baetge E, Kitamura R, Hao E, Beattie GM, Hayek A. Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells. Diabetes. 2007 Mar; 56(3):703-8. PMID: 17327439.
      View in: PubMed
    22. Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6907-12. PMID: 16632596; PMCID: PMC1458992.
    23. Hayek A. Cell replacement in type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2005 Dec; 18 Suppl 1:1157-61. PMID: 16398444.
      View in: PubMed
    24. Beattie GM, Lopez AD, Bucay N, Hinton A, Firpo MT, King CC, Hayek A. Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers. Stem Cells. 2005 Apr; 23(4):489-95. PMID: 15790770.
      View in: PubMed
    25. Kaido T, Perez B, Yebra M, Hill J, Cirulli V, Hayek A, Montgomery AM. Alphav-integrin utilization in human beta-cell adhesion, spreading, and motility. J Biol Chem. 2004 Apr 23; 279(17):17731-7. PMID: 14766759.
      View in: PubMed
    26. Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo MT, Rose-John S, Hayek A. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells. 2004; 22(4):522-30. PMID: 15277698.
      View in: PubMed
    27. Hayek A. In search of endocrine progenitor/stem cells in the human pancreas. Pediatr Diabetes. 2004; 5 Suppl 2:70-4. PMID: 15601376.
      View in: PubMed
    28. Humphrey RK, Bucay N, Beattie GM, Lopez A, Messam CA, Cirulli V, Hayek A. Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas. Diabetes. 2003 Oct; 52(10):2519-25. PMID: 14514635.
      View in: PubMed
    29. Beattie GM, Montgomery AM, Lopez AD, Hao E, Perez B, Just ML, Lakey JR, Hart ME, Hayek A. A novel approach to increase human islet cell mass while preserving beta-cell function. Diabetes. 2002 Dec; 51(12):3435-9. PMID: 12453897.
      View in: PubMed
    30. Movassat J, Beattie GM, Lopez AD, Hayek A. Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells. J Clin Endocrinol Metab. 2002 Oct; 87(10):4775-81. PMID: 12364473.
      View in: PubMed
    31. Hayek A, Beattie GM. Alternatives to unmodified human islets for transplantation. Curr Diab Rep. 2002 Aug; 2(4):371-6. PMID: 12643198.
      View in: PubMed
    32. Humphrey RK, Smith MS, Tuch BE, Hayek A. Regulation of pancreatic cell differentiation and morphogenesis. Pediatr Diabetes. 2002 Mar; 3(1):46-63. PMID: 15016175.
      View in: PubMed
    33. Hayek A, Beattie GM. Experimental transplantation of human fetal and adult pancreatic islets. J Clin Endocrinol Metab. 1997 Aug; 82(8):2471-5. PMID: 9253320.
      View in: PubMed
    34. Hayek A, Beattie GM. Processing, storage and experimental transplantation of human fetal pancreatic cells. Ann Transplant. 1997; 2(3):46-54. PMID: 9869864.
      View in: PubMed
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