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    Alberto Hayek

    TitleSenate Emeritus
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0983
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      SMALL INSTRUMENTATION GRANT
      NIH/NIDDK S15DK046038Aug 1, 1992 - Jul 31, 1993
      Role: Principal Investigator
      SMALL INSTRUMENTATION GRANT
      NIH/NIDDK S15DK044705Aug 1, 1991 - Jul 31, 1992
      Role: Principal Investigator
      SMALL INSTRUMENTATION GRANT
      NIH/NIDDK S15DK043427Jul 15, 1990 - Jun 30, 1991
      Role: Principal Investigator
      ISLET TRANSPLANTATION IN EXPERIMENTAL DIABETES
      NIH/NIDDK R01DK039087Dec 1, 1988 - Nov 30, 1995
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hayek A. Lessons Learned in War. Perm J. 2017; 21. PMID: 28633730.
        View in: PubMed
      2. Hayek A, King CC. Brief review: cell replacement therapies to treat type 1 diabetes mellitus. Clin Diabetes Endocrinol. 2016; 2:4. PMID: 28702240.
        View in: PubMed
      3. Hinton A, Hunter SE, Afrikanova I, Jones GA, Lopez AD, Fogel GB, Hayek A, King CC. sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets. Stem Cells. 2014 Sep; 32(9):2360-72. PMID: 24805944.
        View in: PubMed
      4. Lopez AD, Kayali AG, Hayek A, King CC. Isolation, culture, and imaging of human fetal pancreatic cell clusters. J Vis Exp. 2014 May 18; (87). PMID: 24895054; PMCID: PMC4193289.
        View in: PubMed, PubMed Central
      5. Afrikanova I, Kayali A, Lopez A, Hayek A. Is stage-specific embryonic antigen 4 a marker for human ductal stem/progenitor cells? Biores Open Access. 2012 Aug; 1(4):184-91. PMID: 23515456; PMCID: PMC3559232.
        View in: PubMed, PubMed Central
      6. Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. A new factory for insulin-producing cells: the gut? Regen Med. 2012 Jul; 7(4):473. PMID: 22817622.
        View in: PubMed
      7. Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. Pumping iron in the brain. Regen Med. 2012 Jul; 7(4):474. PMID: 22993884.
        View in: PubMed
      8. Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. Kartogenin: a game-changer in regenerative medicine. Regen Med. 2012 Jul; 7(4):475. PMID: 22993885.
        View in: PubMed
      9. Hayek A, Kerstetter-Fogle AE, Sachlos E, Bollenbach T. Generation of functional hair follicles from follicle germs in a nude mouse model of organ replacement regenerative therapy. Regen Med. 2012 Jul; 7(4):475-6. PMID: 22993886.
        View in: PubMed
      10. Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC. The SDF-1a/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells. PLoS One. 2012; 7(6):e38721. PMID: 22761699; PMCID: PMC3382144.
        View in: PubMed, PubMed Central
      11. Afrikanova I, Yebra M, Simpkinson M, Xu Y, Hayek A, Montgomery A. Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of ß-cells from human pluripotent stem cells. J Biol Chem. 2011 Oct 14; 286(41):36042-52. PMID: 21852242; PMCID: PMC3195622.
        View in: PubMed, PubMed Central
      12. Kaido TJ, Yebra M, Kaneto H, Cirulli V, Hayek A, Montgomery AM. Impact of integrin-matrix interaction and signaling on insulin gene expression and the mesenchymal transition of human beta-cells. J Cell Physiol. 2010 Jul; 224(1):101-11. PMID: 20232313.
        View in: PubMed
      13. Hinton A, Afrikanova I, Wilson M, King CC, Maurer B, Yeo GW, Hayek A, Pasquinelli AE. A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells. Stem Cells Dev. 2010 Jun; 19(6):797-807. PMID: 19807270.
        View in: PubMed
      14. Xu Y, Zhu X, Hahm HS, Wei W, Hao E, Hayek A, Ding S. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8129-34. PMID: 20406903; PMCID: PMC2889586.
        View in: PubMed, PubMed Central
      15. Li W, Zhou H, Abujarour R, Zhu S, Young Joo J, Lin T, Hao E, Schöler HR, Hayek A, Ding S. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells. 2009 Dec; 27(12):2992-3000. PMID: 19839055; PMCID: PMC3780784.
        View in: PubMed, PubMed Central
      16. Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S. A chemical platform for improved induction of human iPSCs. Nat Methods. 2009 Nov; 6(11):805-8. PMID: 19838168; PMCID: PMC3724527.
        View in: PubMed, PubMed Central
      17. Bucay N, Yebra M, Cirulli V, Afrikanova I, Kaido T, Hayek A, Montgomery AM. A novel approach for the derivation of putative primordial germ cells and sertoli cells from human embryonic stem cells. Stem Cells. 2009 Jan; 27(1):68-77. PMID: 18845765.
        View in: PubMed
      18. Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H, Ding S. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell. 2009 Jan 09; 4(1):16-9. PMID: 19097958.
        View in: PubMed
      19. King CC, Beattie GM, Lopez AD, Hayek A. Generation of definitive endoderm from human embryonic stem cells cultured in feeder layer-free conditions. Regen Med. 2008 Mar; 3(2):175-80. PMID: 18307401.
        View in: PubMed
      20. Fousteri G, Hayek A, von Herrath M. Stopping diabetes in its tracks: autologous non-myeloablative stem cell transplantation. Regen Med. 2007 Sep; 2(5):845-51. PMID: 17907936.
        View in: PubMed
      21. Kayali AG, Flores LE, Lopez AD, Kutlu B, Baetge E, Kitamura R, Hao E, Beattie GM, Hayek A. Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells. Diabetes. 2007 Mar; 56(3):703-8. PMID: 17327439.
        View in: PubMed
      22. Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6907-12. PMID: 16632596; PMCID: PMC1458992.
        View in: PubMed, PubMed Central
      23. Hayek A. Cell replacement in type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2005 Dec; 18 Suppl 1:1157-61. PMID: 16398444.
        View in: PubMed
      24. Beattie GM, Lopez AD, Bucay N, Hinton A, Firpo MT, King CC, Hayek A. Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers. Stem Cells. 2005 Apr; 23(4):489-95. PMID: 15790770.
        View in: PubMed
      25. Kaido T, Perez B, Yebra M, Hill J, Cirulli V, Hayek A, Montgomery AM. Alphav-integrin utilization in human beta-cell adhesion, spreading, and motility. J Biol Chem. 2004 Apr 23; 279(17):17731-7. PMID: 14766759.
        View in: PubMed
      26. Hayek A. In search of endocrine progenitor/stem cells in the human pancreas. Pediatr Diabetes. 2004; 5 Suppl 2:70-4. PMID: 15601376.
        View in: PubMed
      27. Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo MT, Rose-John S, Hayek A. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells. 2004; 22(4):522-30. PMID: 15277698.
        View in: PubMed
      28. Humphrey RK, Bucay N, Beattie GM, Lopez A, Messam CA, Cirulli V, Hayek A. Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas. Diabetes. 2003 Oct; 52(10):2519-25. PMID: 14514635.
        View in: PubMed
      29. Movassat J, Beattie GM, Lopez AD, Portha B, Hayek A. Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells. Diabetologia. 2003 Jun; 46(6):822-9. PMID: 12802496.
        View in: PubMed
      30. Beattie GM, Montgomery AM, Lopez AD, Hao E, Perez B, Just ML, Lakey JR, Hart ME, Hayek A. A novel approach to increase human islet cell mass while preserving beta-cell function. Diabetes. 2002 Dec; 51(12):3435-9. PMID: 12453897.
        View in: PubMed
      31. Movassat J, Beattie GM, Lopez AD, Hayek A. Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells. J Clin Endocrinol Metab. 2002 Oct; 87(10):4775-81. PMID: 12364473.
        View in: PubMed
      32. Hayek A, Beattie GM. Alternatives to unmodified human islets for transplantation. Curr Diab Rep. 2002 Aug; 2(4):371-6. PMID: 12643198.
        View in: PubMed
      33. Humphrey RK, Smith MS, Tuch BE, Hayek A. Regulation of pancreatic cell differentiation and morphogenesis. Pediatr Diabetes. 2002 Mar; 3(1):46-63. PMID: 15016175.
        View in: PubMed
      34. Demeterco C, Beattie GM, Dib SA, Lopez AD, Hayek A. A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth. J Clin Endocrinol Metab. 2000 Oct; 85(10):3892-7. PMID: 11061554.
        View in: PubMed
      35. Halvorsen TL, Beattie GM, Lopez AD, Hayek A, Levine F. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J Endocrinol. 2000 Jul; 166(1):103-9. PMID: 10856888.
        View in: PubMed
      36. Itkin-Ansari P, Demeterco C, Bossie S, de la Tour DD, Beattie GM, Movassat J, Mally MI, Hayek A, Levine F. PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell line. Mol Endocrinol. 2000 Jun; 14(6):814-22. PMID: 10847584.
        View in: PubMed
      37. Beattie GM, Leibowitz G, Lopez AD, Levine F, Hayek A. Protection from cell death in cultured human fetal pancreatic cells. Cell Transplant. 2000 May-Jun; 9(3):431-8. PMID: 10972342.
        View in: PubMed
      38. Beattie GM, Hayek A, Levine F. Growth and genetic modification of human beta-cells and beta-cell precursors. Genet Eng (N Y). 2000; 22:99-120. PMID: 11501383.
        View in: PubMed
      39. Beattie GM, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez AD, Bossie S, Mally MI, Levine F, Hayek A. Sustained proliferation of PDX-1+ cells derived from human islets. Diabetes. 1999 May; 48(5):1013-9. PMID: 10331405.
        View in: PubMed
      40. Leibowitz G, Beattie GM, Kafri T, Cirulli V, Lopez AD, Hayek A, Levine F. Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes. 1999 Apr; 48(4):745-53. PMID: 10102690.
        View in: PubMed
      41. Beattie GM, Lopez AD, Otonkoski T, Hayek A. Transplantation of human fetal pancreas: fresh vs. cultured fetal islets or ICCS. J Mol Med (Berl). 1999 Jan; 77(1):70-3. PMID: 9930931.
        View in: PubMed
      42. Cirulli V, Crisa L, Beattie GM, Mally MI, Lopez AD, Fannon A, Ptasznik A, Inverardi L, Ricordi C, Deerinck T, Ellisman M, Reisfeld RA, Hayek A. KSA antigen Ep-CAM mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development. J Cell Biol. 1998 Mar 23; 140(6):1519-34. PMID: 9508783; PMCID: PMC2132663.
        View in: PubMed, PubMed Central
      43. Hayek A, McCluskey BJ, Chavez GT, Salman MD. Financial impact of the 1995 outbreak of vesicular stomatitis on 16 beef ranches in Colorado. J Am Vet Med Assoc. 1998 Mar 15; 212(6):820-3. PMID: 9530419.
        View in: PubMed
      44. Hayek A, Beattie GM. Experimental transplantation of human fetal and adult pancreatic islets. J Clin Endocrinol Metab. 1997 Aug; 82(8):2471-5. PMID: 9253320.
        View in: PubMed
      45. Ptasznik A, Beattie GM, Mally MI, Cirulli V, Lopez A, Hayek A. Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation. J Cell Biol. 1997 Jun 02; 137(5):1127-36. PMID: 9166412; PMCID: PMC2136228.
        View in: PubMed, PubMed Central
      46. Wang S, Beattie GM, Mally MI, Lopez AD, Hayek A, Levine F. Analysis of a human fetal pancreatic islet cell line. Transplant Proc. 1997 Jun; 29(4):2219. PMID: 9193600.
        View in: PubMed
      47. Beattie GM, Cirulli V, Lopez AD, Hayek A. Ex vivo expansion of human pancreatic endocrine cells. J Clin Endocrinol Metab. 1997 Jun; 82(6):1852-6. PMID: 9177395.
        View in: PubMed
      48. Beattie GM, Crowe JH, Lopez AD, Cirulli V, Ricordi C, Hayek A. Trehalose: a cryoprotectant that enhances recovery and preserves function of human pancreatic islets after long-term storage. Diabetes. 1997 Mar; 46(3):519-23. PMID: 9032112.
        View in: PubMed
      49. Beattie GM, Otonkoski T, Lopez AD, Hayek A. Functional beta-cell mass after transplantation of human fetal pancreatic cells: differentiation or proliferation? Diabetes. 1997 Feb; 46(2):244-8. PMID: 9000701.
        View in: PubMed
      50. Wang S, Beattie GM, Mally MI, Cirulli V, Itkin-Ansari P, Lopez AD, Hayek A, Levine F. Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas. Cell Transplant. 1997 Jan-Feb; 6(1):59-67. PMID: 9040956.
        View in: PubMed
      51. Hayek A, Beattie GM. Processing, storage and experimental transplantation of human fetal pancreatic cells. Ann Transplant. 1997; 2(3):46-54. PMID: 9869864.
        View in: PubMed
      52. Wang S, Beattie GM, Hayek A, Levine F. Development of a VSV-G protein pseudotyped retroviral vector system expressing dominant oncogenes from a lacO-modified inducible LTR promoter. Gene. 1996 Dec 05; 182(1-2):145-50. PMID: 8982080.
        View in: PubMed
      53. Beattie GM, Rubin JS, Mally MI, Otonkoski T, Hayek A. Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact. Diabetes. 1996 Sep; 45(9):1223-8. PMID: 8772726.
        View in: PubMed
      54. Itkin-Ansari P, Bain G, Beattie GM, Murre C, Hayek A, Levine F. E2A gene products are not required for insulin gene expression. Endocrinology. 1996 Aug; 137(8):3540-3. PMID: 8754784.
        View in: PubMed
      55. Otonkoski T, Cirulli V, Beattie M, Mally MI, Soto G, Rubin JS, Hayek A. A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology. 1996 Jul; 137(7):3131-9. PMID: 8770939.
        View in: PubMed
      56. Mally MI, Cirulli V, Otonkoski T, Soto G, Hayek A. Ontogeny and tissue distribution of human GAD expression. Diabetes. 1996 Apr; 45(4):496-501. PMID: 8603772.
        View in: PubMed
      57. Mally MI, Cirulli V, Hayek A, Otonkoski T. ICA69 is expressed equally in the human endocrine and exocrine pancreas. Diabetologia. 1996 Apr; 39(4):474-80. PMID: 8777998.
        View in: PubMed
      58. Cirulli V, Ricordi C, Hayek A. E-cadherin, NCAM, and EpCAM expression in human fetal pancreata. Transplant Proc. 1995 Dec; 27(6):3335. PMID: 8539977.
        View in: PubMed
      59. Beattie GM, Lopez AD, Hayek A. In vivo maturation and growth potential of human fetal pancreases: fresh versus cultured tissue. Transplant Proc. 1995 Dec; 27(6):3343. PMID: 8539983.
        View in: PubMed
      60. Hayek A, Beattie GM, Cirulli V, Lopez AD, Ricordi C, Rubin JS. Growth factor/matrix-induced proliferation of human adult beta-cells. Diabetes. 1995 Dec; 44(12):1458-60. PMID: 7589854.
        View in: PubMed
      61. Levine F, Wang S, Beattie GM, Mally MI, Cirulli V, Lopez AD, Hayek A. Development of a cell line from the human fetal pancreas. Transplant Proc. 1995 Dec; 27(6):3410. PMID: 8540023.
        View in: PubMed
      62. Levine F, Beattie GM, Hayek A. Differential integrin expression facilitates isolation of human fetal pancreatic epithelial cells. Cell Transplant. 1994 Jul-Aug; 3(4):307-13. PMID: 7921635.
        View in: PubMed
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