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    Roger Sunahara

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0636
    CA La Jolla 92093
    Phone858-246-1967
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Ph.D.University of Toronto

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Next-gen Opto-GPCRs: spatiotemporal simulation of neuromodulator signaling
      NIH R01MH111520Sep 9, 2016 - Jul 31, 2019
      Role: Principal Investigator
      Structure-based discovery of allosteric ligands for G Protein Coupled Receptors
      NIH U19GM106990Sep 15, 2013 - May 31, 2018
      Role: Co-Investigator
      Crystallization and structure determination of the mu-opioid receptor
      NIH R21DA031418Jul 1, 2011 - Jun 30, 2013
      Role: Principal Investigator
      Structure and dynamics of G protein coupled receptor-G protein complexes
      NIH R01GM083118May 1, 2008 - May 31, 2020
      Role: Principal Investigator
      Structure and mechanism of beta2-adrenergic receptor
      NIH R01GM068603Aug 1, 2003 - Jul 31, 2008
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Mahoney JP, Sunahara R. Mechanistic insights into GPCR-G protein interactions. Curr Opin Struct Biol. 2016 Nov 18; 41:247-254. PMID: 27871057.
        View in: PubMed
      2. Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara R, Skiniotis G, Bouvier M, Lefkowitz RJ. GPCR-G Protein-ß-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. 2016 Aug 11; 166(4):907-19. PMID: 27499021.
        View in: PubMed
      3. DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara R. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. 2016 Jul 7; 535(7610):182-6. PMID: 27362234.
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      4. Sunahara R, Insel PA. The Molecular Pharmacology of G Protein Signaling Then and Now: A Tribute to Alfred G. Gilman. Mol Pharmacol. 2016 May; 89(5):585-92. PMID: 26984025.
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      5. Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. Pharmacological chaperone for a-crystallin partially restores transparency in cataract models. Science. 2015 Nov 6; 350(6261):674-7. PMID: 26542570.
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      6. Mallik L, Dhakal S, Nichols J, Mahoney J, Dosey AM, Jiang S, Sunahara R, Skiniotis G, Walter NG. Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami. ACS Nano. 2015 Jul 28; 9(7):7133-41. PMID: 26149412.
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      7. Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara R, Shaw DE. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science. 2015 Jun 19; 348(6241):1361-5. PMID: 26089515.
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      8. Howell LL, Nye JA, Stehouwer JS, Voll RJ, Mun J, Narasimhan D, Nichols J, Sunahara R, Goodman MM, Carroll FI, Woods JH. A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates. Transl Psychiatry. 2014; 4:e407. PMID: 24984194.
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      9. Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara R, Sivaramakrishnan S. Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. J Biol Chem. 2013 Jun 14; 288(24):17167-78. PMID: 23629648.
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      10. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara R, El-Samad H, Huang B, von Zastrow M. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013 Mar 28; 495(7442):534-8. PMID: 23515162.
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      11. Mitra N, Liu Y, Liu J, Serebryany E, Mooney V, DeVree BT, Sunahara R, Yan EC. Calcium-dependent ligand binding and G-protein signaling of family B GPCR parathyroid hormone 1 receptor purified in nanodiscs. ACS Chem Biol. 2013 Mar 15; 8(3):617-25. PMID: 23237450.
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      12. Chung KY, Day PW, Vélez-Ruiz G, Sunahara R, Kobilka BK. Identification of GPCR-interacting cytosolic proteins using HDL particles and mass spectrometry-based proteomic approach. PLoS One. 2013; 8(1):e54942. PMID: 23372797.
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      13. Collins GT, Brim RL, Noon KR, Narasimhan D, Lukacs NW, Sunahara R, Woods JH, Ko MC. Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. J Pharmacol Exp Ther. 2012 Jul; 342(1):205-13. PMID: 22518021.
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      14. Lee TY, Park YS, Garcia GA, Sunahara R, Woods JH, Yang VC. Cell permeable cocaine esterases constructed by chemical conjugation and genetic recombination. Mol Pharm. 2012 May 7; 9(5):1361-73. PMID: 22404344.
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      15. Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara R, Pardo L, Weis WI, Kobilka BK, Granier S. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 May 17; 485(7398):321-6. PMID: 22437502.
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      16. Narasimhan D, Woods JH, Sunahara R. Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction. Future Med Chem. 2012 Feb; 4(2):137-50. PMID: 22300094.
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      17. Collins GT, Narasimhan D, Cunningham AR, Zaks ME, Nichols J, Ko MC, Sunahara R, Woods JH. Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats. Neuropsychopharmacology. 2012 Apr; 37(5):1092-103. PMID: 21993206.
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      18. Brim RL, Noon KR, Collins GT, Stein A, Nichols J, Narasimhan D, Ko MC, Woods JH, Sunahara R. The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination. J Pharmacol Exp Ther. 2012 Jan; 340(1):83-95. PMID: 21990608.
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      19. Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL, Sunahara R. Conformational changes in the G protein Gs induced by the ß2 adrenergic receptor. Nature. 2011 Sep 29; 477(7366):611-5. PMID: 21956331.
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      20. Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL, Steyaert J, Kobilka BK, Sunahara R, Skiniotis G. Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):16086-91. PMID: 21914848.
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      21. Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J, Ko MC, Woods JH, Tesmer JJ, Sunahara R. Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time. Mol Pharmacol. 2011 Dec; 80(6):1056-65. PMID: 21890748.
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      22. Brim RL, Noon KR, Collins GT, Nichols J, Narasimhan D, Sunahara R, Woods JH. The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry. Mol Pharmacol. 2011 Dec; 80(6):1119-27. PMID: 21885621.
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      23. Brim RL, Noon KR, Nichols J, Narasimhan D, Woods JH, Sunahara R. Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs. Drug Alcohol Depend. 2011 Dec 15; 119(3):224-8. PMID: 21775073.
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      24. Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara R, Kobilka BK. Crystal structure of the ß2 adrenergic receptor-Gs protein complex. Nature. 2011 Sep 29; 477(7366):549-55. PMID: 21772288.
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      25. Collins GT, Zaks ME, Cunningham AR, St Clair C, Nichols J, Narasimhan D, Ko MC, Sunahara R, Woods JH. Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats. Drug Alcohol Depend. 2011 Nov 1; 118(2-3):158-65. PMID: 21481548.
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      26. Collins GT, Carey KA, Narasimhan D, Nichols J, Berlin AA, Lukacs NW, Sunahara R, Woods JH, Ko MC. Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology. 2011 Apr; 36(5):1047-59. PMID: 21289605.
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      27. Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara R, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK. Structure of a nanobody-stabilized active state of the ß(2) adrenoceptor. Nature. 2011 Jan 13; 469(7329):175-80. PMID: 21228869.
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      28. Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara R, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK. Structure and function of an irreversible agonist-ß(2) adrenoceptor complex. Nature. 2011 Jan 13; 469(7329):236-40. PMID: 21228876.
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      29. Vélez-Ruiz GA, Sunahara R. Reconstitution of G protein-coupled receptors into a model bilayer system: reconstituted high-density lipoprotein particles. Methods Mol Biol. 2011; 756:167-82. PMID: 21870225.
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      30. Narasimhan D, Nance MR, Gao D, Ko MC, Macdonald J, Tamburi P, Yoon D, Landry DM, Woods JH, Zhan CG, Tesmer JJ, Sunahara R. Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng Des Sel. 2010 Jul; 23(7):537-47. PMID: 20436035.
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      31. Brim RL, Nance MR, Youngstrom DW, Narasimhan D, Zhan CG, Tesmer JJ, Sunahara R, Woods JH. A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Mol Pharmacol. 2010 Apr; 77(4):593-600. PMID: 20086035.
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      32. Park JB, Kwon YM, Lee TY, Brim R, Ko MC, Sunahara R, Woods JH, Yang VC. PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity. J Control Release. 2010 Mar 3; 142(2):174-9. PMID: 19857534.
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      33. Wood SK, Narasimhan D, Cooper Z, Sunahara R, Woods JH. Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats. Drug Alcohol Depend. 2010 Jan 15; 106(2-3):219-29. PMID: 19800183.
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      34. Fung JJ, Deupi X, Pardo L, Yao XJ, Velez-Ruiz GA, Devree BT, Sunahara R, Kobilka BK. Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. EMBO J. 2009 Nov 4; 28(21):3315-28. PMID: 19763081.
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      35. Collins GT, Brim RL, Narasimhan D, Ko MC, Sunahara R, Zhan CG, Woods JH. Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. J Pharmacol Exp Ther. 2009 Nov; 331(2):445-55. PMID: 19710369.
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      36. Kuszak AJ, Pitchiaya S, Anand JP, Mosberg HI, Walter NG, Sunahara R. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. J Biol Chem. 2009 Sep 25; 284(39):26732-41. PMID: 19542234.
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      37. Yao XJ, Vélez Ruiz G, Whorton MR, Rasmussen SG, DeVree BT, Deupi X, Sunahara R, Kobilka B. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc Natl Acad Sci U S A. 2009 Jun 9; 106(23):9501-6. PMID: 19470481.
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      38. Ko MC, Narasimhan D, Berlin AA, Lukacs NW, Sunahara R, Woods JH. Effects of cocaine esterase following its repeated administration with cocaine in mice. Drug Alcohol Depend. 2009 May 1; 101(3):202-9. PMID: 19217723.
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      39. Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara R, Woods JH. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. J Pharmacol Exp Ther. 2009 Apr; 329(1):210-7. PMID: 19136638.
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      40. Jutkiewicz EM, Baladi MG, Cooper ZD, Narasimhan D, Sunahara R, Woods JH. A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. Ann Emerg Med. 2009 Sep; 54(3):409-20. PMID: 19013687.
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      41. Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara R, Zhan CG. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Mol Pharmacol. 2009 Feb; 75(2):318-23. PMID: 18987161.
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      42. Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara R. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem. 2008 Feb 15; 283(7):4387-94. PMID: 18033822.
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      43. Cunliffe JM, Sunahara R, Kennedy RT. Detection of g protein coupled receptor mediated adenylyl cyclase activity by capillary electrophoresis using fluorescently labeled ATP. Anal Chem. 2007 Oct 1; 79(19):7534-9. PMID: 17718540.
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      44. Cunliffe JM, Whorton MR, Sunahara R, Kennedy RT. A CE assay for the detection of agonist-stimulated adenylyl cyclase activity. Electrophoresis. 2007 Jun; 28(12):1913-20. PMID: 17480040.
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      45. Vadakkadathmeethal K, Cunliffe JM, Swift J, Kennedy RT, Neubig RR, Sunahara R. Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening. Comb Chem High Throughput Screen. 2007 May; 10(4):289-98. PMID: 17506713.
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      46. Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara R. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A. 2007 May 1; 104(18):7682-7. PMID: 17452637.
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      47. Walter NG, Meiners JC, Meyhofer E, Neubig RR, Sunahara R, Perkins NC, Steel DG, Swanson JA. Under the microscope: single molecule symposium at the University of Michigan, 2006. Biopolymers. 2007 Feb 5; 85(2):106-14. PMID: 17080420.
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      48. Benson MD, Li QJ, Kieckhafer K, Dudek D, Whorton MR, Sunahara R, Iñiguez-Lluhí JA, Martens JR. SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proc Natl Acad Sci U S A. 2007 Feb 6; 104(6):1805-10. PMID: 17261810.
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      49. Bodenstein J, Sunahara R, Neubig RR. N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Mol Pharmacol. 2007 Apr; 71(4):1040-50. PMID: 17220356.
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      50. Ko MC, Bowen LD, Narasimhan D, Berlin AA, Lukacs NW, Sunahara R, Cooper ZD, Woods JH. Cocaine esterase: interactions with cocaine and immune responses in mice. J Pharmacol Exp Ther. 2007 Feb; 320(2):926-33. PMID: 17114567.
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      51. Roman DL, Talbot JN, Roof RA, Sunahara R, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Mol Pharmacol. 2007 Jan; 71(1):169-75. PMID: 17012620.
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      52. Cooper ZD, Narasimhan D, Sunahara R, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol. 2006 Dec; 70(6):1885-91. PMID: 16968810.
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      53. Roof RA, Jin Y, Roman DL, Sunahara R, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chem Biol Drug Des. 2006 Apr; 67(4):266-74. PMID: 16629824.
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      54. Cunliffe JM, Sunahara R, Kennedy RT. Detection of adenylyl cyclase activity using a fluorescent ATP substrate and capillary electrophoresis. Anal Chem. 2006 Mar 15; 78(6):1731-8. PMID: 16536404.
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      55. Giguère P, Rochdi MD, Laroche G, Dupré E, Whorton MR, Sunahara R, Claing A, Dupuis G, Parent JL. ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6. Cell Signal. 2006 Nov; 18(11):1988-94. PMID: 16650966.
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      56. Morishima Y, Peng HM, Lin HL, Hollenberg PF, Sunahara R, Osawa Y, Pratt WB. Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry. 2005 Dec 13; 44(49):16333-40. PMID: 16331994.
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      57. Vadakkadathmeethal K, Felczak A, Davignon I, Collins J, Sunahara R. Cloning and characterization of the G protein betagamma subunits from Trichoplusia ni (High Five cells). Insect Biochem Mol Biol. 2005 Apr; 35(4):333-45. PMID: 15763469.
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      58. Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J Lipid Res. 2005 Jun; 46(6):1239-47. PMID: 15772423.
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      59. Chang FJ, Lemme S, Sun Q, Sunahara R, Beuve A. Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase. J Biol Chem. 2005 Mar 25; 280(12):11513-9. PMID: 15649897.
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      60. Jameson EE, Roof RA, Whorton MR, Mosberg HI, Sunahara R, Neubig RR, Kennedy RT. Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues. J Biol Chem. 2005 Mar 4; 280(9):7712-9. PMID: 15613467.
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      61. Whelan RJ, Sunahara R, Neubig RR, Kennedy RT. Affinity assays using fluorescence anisotropy with capillary electrophoresis separation. Anal Chem. 2004 Dec 15; 76(24):7380-6. PMID: 15595883.
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      62. Klein C, Heyduk T, Sunahara R. Zinc inhibition of adenylyl cyclase correlates with conformational changes in the enzyme. Cell Signal. 2004 Oct; 16(10):1177-85. PMID: 15240012.
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      63. Krumins AM, Barker SA, Huang C, Sunahara R, Yu K, Wilkie TM, Gold SJ, Mumby SM. Differentially regulated expression of endogenous RGS4 and RGS7. J Biol Chem. 2004 Jan 23; 279(4):2593-9. PMID: 14604980.
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      64. Morishima Y, Kanelakis KC, Murphy PJ, Lowe ER, Jenkins GJ, Osawa Y, Sunahara R, Pratt WB. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem. 2003 Dec 5; 278(49):48754-63. PMID: 14507910.
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      65. Jameson EE, Cunliffe JM, Neubig RR, Sunahara R, Kennedy RT. Detection of G proteins by affinity probe capillary electrophoresis using a fluorescently labeled GTP analogue. Anal Chem. 2003 Aug 15; 75(16):4297-304. PMID: 14632149.
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      66. Sunahara R, Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv. 2002 Jun; 2(3):168-84. PMID: 14993377.
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      67. Klein C, Sunahara R, Hudson TY, Heyduk T, Howlett AC. Zinc inhibition of cAMP signaling. J Biol Chem. 2002 Apr 5; 277(14):11859-65. PMID: 11805091.
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      68. Hatley ME, Gilman AG, Sunahara R. Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods Enzymol. 2002; 345:127-40. PMID: 11665600.
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      69. Tesmer JJ, Sunahara R, Fancy DA, Gilman AG, Sprang SR. Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha. Methods Enzymol. 2002; 345:198-206. PMID: 11665605.
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      70. Wang L, Sunahara R, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH, Taylor SS. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3220-5. PMID: 11248059.
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      71. Hatley ME, Benton BK, Xu J, Manfredi JP, Gilman AG, Sunahara R. Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase. J Biol Chem. 2000 Dec 8; 275(49):38626-32. PMID: 10982815.
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      72. Tesmer JJ, Dessauer CW, Sunahara R, Murray LD, Johnson RA, Gilman AG, Sprang SR. Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry. 2000 Nov 28; 39(47):14464-71. PMID: 11087399.
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      73. Tesmer JJ, Sunahara R, Johnson RA, Gosselin G, Gilman AG, Sprang SR. Two-metal-Ion catalysis in adenylyl cyclase. Science. 1999 Jul 30; 285(5428):756-60. PMID: 10427002.
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      74. Sunahara R, Beuve A, Tesmer JJ, Sprang SR, Garbers DL, Gilman AG. Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. J Biol Chem. 1998 Jun 26; 273(26):16332-8. PMID: 9632695.
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      75. Sunahara R, Tesmer JJ, Gilman AG, Sprang SR. Crystal structure of the adenylyl cyclase activator Gsalpha. Science. 1997 Dec 12; 278(5345):1943-7. PMID: 9395396.
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      76. Tesmer JJ, Sunahara R, Gilman AG, Sprang SR. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science. 1997 Dec 12; 278(5345):1907-16. PMID: 9417641.
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      77. Svenningsson P, Le Moine C, Kull B, Sunahara R, Bloch B, Fredholm BB. Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience. 1997 Oct; 80(4):1171-85. PMID: 9284069.
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      78. Sunahara R, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG. Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase. J Biol Chem. 1997 Aug 29; 272(35):22265-71. PMID: 9268375.
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      79. Durante W, Christodoulides N, Cheng K, Peyton KJ, Sunahara R, Schafer AI. cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle. Am J Physiol. 1997 Jul; 273(1 Pt 2):H317-23. PMID: 9249506.
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      80. Sunahara R, Dessauer CW, Gilman AG. Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol. 1996; 36:461-80. PMID: 8725398.
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      81. Seeman P, Sunahara R, Niznik HB. Receptor-receptor link in membranes revealed by ligand competition: example for dopamine D1 and D2 receptors. Synapse. 1994 May; 17(1):62-4. PMID: 8042146.
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      82. Demchyshyn LL, Srikant CB, Sunahara R, Kent G, Seeman P, Van Tol HH, Panetta R, Patel YC, Niznik HB. Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. Mol Pharmacol. 1993 Jun; 43(6):894-901. PMID: 8100352.
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      83. Gelernter J, Kennedy JL, Grandy DK, Zhou QY, Civelli O, Pauls DL, Pakstis A, Kurlan R, Sunahara R, Niznik HB. Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor. Am J Psychiatry. 1993 Mar; 150(3):449-53. PMID: 8434661.
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      84. Ohara K, Ulpian C, Seeman P, Sunahara R, Van Tol HH, Niznik HB. Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms. Neuropsychopharmacology. 1993 Feb; 8(2):131-5. PMID: 8471124.
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      85. Sugamori KS, Sunahara R, Guan HC, Bulloch AG, Tensen CP, Seeman P, Niznik HB, Van Tol HH. Serotonin receptor cDNA cloned from Lymnaea stagnalis. Proc Natl Acad Sci U S A. 1993 Jan 1; 90(1):11-5. PMID: 8093556.
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      86. Seeman P, Guan HC, Civelli O, Van Tol HH, Sunahara R, Niznik HB. The cloned dopamine D2 receptor reveals different densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography. Eur J Pharmacol. 1992 Oct 1; 227(2):139-46. PMID: 1358662.
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