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    James Beadle

    TitleRecall Non-faculty Academic
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0676
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Beadle J, Valiaeva N, Yang G, Yu JH, Broker TR, Aldern KA, Harden EA, Keith KA, Prichard MN, Hartman T, Buckheit RW, Chow LT, Hostetler KY. Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification. J Med Chem. 2016 Dec 08; 59(23):10470-10478. PMID: 27933957.
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      2. Ma F, Nan K, Lee S, Beadle J, Hou H, Freeman WR, Hostetler KY, Cheng L. Micelle formulation of hexadecyloxypropyl-cidofovir (HDP-CDV) as an intravitreal long-lasting delivery system. Eur J Pharm Biopharm. 2015 Jan; 89:271-9. PMID: 25513956; PMCID: PMC4355386.
      3. Kim JS, Beadle J, Freeman WR, Hostetler KY, Hartmann K, Valiaeva N, Kozak I, Conner L, Trahan J, Aldern KA, Cheng L. A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy. Mol Vis. 2012; 18:1907-17. PMID: 22876115; PMCID: PMC3413433.
      4. Wang H, Chhablani J, Freeman WR, Beadle J, Hostetler KY, Hartmann K, Conner L, Aldern KA, Pearson L, Cheng L. Intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV) as a long-lasting intravitreal antiviral drug. Invest Ophthalmol Vis Sci. 2011 Dec 09; 52(13):9391-6. PMID: 22058340; PMCID: PMC3250264.
      5. Magee WC, Valiaeva N, Beadle J, Richman DD, Hostetler KY, Evans DH. Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action. Antimicrob Agents Chemother. 2011 Nov; 55(11):5063-72. PMID: 21896914; PMCID: PMC3195056.
      6. Valiaeva N, Wyles DL, Schooley RT, Hwu JB, Beadle J, Prichard MN, Hostetler KY. Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication. Bioorg Med Chem. 2011 Aug 01; 19(15):4616-25. PMID: 21719300; PMCID: PMC3139790.
      7. Ruiz J, Beadle J, Buller RM, Schreiwer J, Prichard MN, Keith KA, Lewis KC, Hostetler KY. Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine. Bioorg Med Chem. 2011 May 01; 19(9):2950-8. PMID: 21493074; PMCID: PMC3104040.
      8. Hou J, Li Y, Zhou Z, Valiaeva N, Beadle J, Hostetler K, Freeman WR, Hu DN, Chen H, Cheng L. Antiproliferative property of hexadecyloxypropyl 9-[2-(phosphonomethoxy) ethyl] guanine (HDP-PMEG) for unwanted ocular proliferation. Mol Vis. 2011 Mar 02; 17:627-37. PMID: 21386925; PMCID: PMC3049735.
      9. Cheng L, Beadle J, Tammewar A, Hostetler KY, Hoh C, Freeman WR. Intraocular pharmacokinetics of a crystalline lipid prodrug, octadecyloxyethyl-cyclic-cidofovir, for cytomegalovirus retinitis. J Ocul Pharmacol Ther. 2011 Apr; 27(2):157-62. PMID: 21351867; PMCID: PMC3078534.
      10. Julien O, Beadle J, Magee WC, Chatterjee S, Hostetler KY, Evans DH, Sykes BD. Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir. J Am Chem Soc. 2011 Feb 23; 133(7):2264-74. PMID: 21280608; PMCID: PMC3051402.
      11. Bravo FJ, Bernstein DI, Beadle J, Hostetler KY, Cardin RD. Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection. Antimicrob Agents Chemother. 2011 Jan; 55(1):35-41. PMID: 21078944; PMCID: PMC3019685.
      12. Valiaeva N, Trahan J, Aldern KA, Beadle J, Hostetler KY. Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo. Chemotherapy. 2010; 56(1):54-9. PMID: 20215748; PMCID: PMC2914419.
      13. Valiaeva N, Prichard MN, Buller RM, Beadle J, Hartline CB, Keith KA, Schriewer J, Trahan J, Hostetler KY. Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses. Antiviral Res. 2009 Dec; 84(3):254-9. PMID: 19800369; PMCID: PMC2787864.
      14. Botros SS, William S, Beadle J, Valiaeva N, Hostetler KY. Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro. Antimicrob Agents Chemother. 2009 Dec; 53(12):5284-7. PMID: 19704122; PMCID: PMC2786359.
      15. Cheng L, Hostetler K, Valiaeva N, Tammewar A, Freeman WR, Beadle J, Bartsch DU, Aldern K, Falkenstein I. Intravitreal crystalline drug delivery for intraocular proliferation diseases. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):474-81. PMID: 19696179; PMCID: PMC2869063.
      16. Morrey JD, Korba BE, Beadle J, Wyles DL, Hostetler KY. Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo. Antimicrob Agents Chemother. 2009 Jul; 53(7):2865-70. PMID: 19398648; PMCID: PMC2704649.
      17. Wyles DL, Kaihara KA, Korba BE, Schooley RT, Beadle J, Hostetler KY. The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons. Antimicrob Agents Chemother. 2009 Jun; 53(6):2660-2. PMID: 19289518; PMCID: PMC2687240.
      18. Prichard MN, Hartline CB, Harden EA, Daily SL, Beadle J, Valiaeva N, Kern ER, Hostetler KY. Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates. Antimicrob Agents Chemother. 2008 Dec; 52(12):4326-30. PMID: 18852272; PMCID: PMC2592848.
      19. Quenelle DC, Collins DJ, Pettway LR, Hartline CB, Beadle J, Wan WB, Hostetler KY, Kern ER. Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models. Antiviral Res. 2008 Aug; 79(2):133-5. PMID: 18336926; PMCID: PMC2650230.
      20. Randhawa P, Zemlicka J, Sauerbrei A, Meier C, Hostetler KY, Beadle J, Farasati NA, Huang Y, Bradley M. Anti-BK virus activity of nucleoside analogs. Antimicrob Agents Chemother. 2008 Apr; 52(4):1519-21. PMID: 18285481; PMCID: PMC2292553.
      21. Tammewar AM, Cheng L, Hostetler KY, Falkenstein I, Beadle J, Barron EC, Kozak I, Freeman WR. Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig. J Ocul Pharmacol Ther. 2007 Oct; 23(5):433-44. PMID: 17900229.
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      22. Quenelle DC, Collins DJ, Herrod BP, Keith KA, Trahan J, Beadle J, Hostetler KY, Kern ER. Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice. Antimicrob Agents Chemother. 2007 Nov; 51(11):3940-7. PMID: 17846137; PMCID: PMC2151427.
      23. Painter GR, Almond MR, Trost LC, Lampert BM, Neyts J, De Clercq E, Korba BE, Aldern KA, Beadle J, Hostetler KY. Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections. Antimicrob Agents Chemother. 2007 Oct; 51(10):3505-9. PMID: 17646420; PMCID: PMC2043283.
      24. Beadle J. Synthesis of cidofovir and (S)-HPMPA ether lipid prodrugs. Curr Protoc Nucleic Acid Chem. 2007 Jun; Chapter 15:Unit 15.2. PMID: 18428972.
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      25. Dal Pozzo F, Andrei G, Lebeau I, Beadle J, Hostetler KY, De Clercq E, Snoeck R. In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Antiviral Res. 2007 Jul; 75(1):52-7. PMID: 17184854.
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      26. Choo H, Beadle J, Chong Y, Trahan J, Hostetler KY. Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates. Bioorg Med Chem. 2007 Feb 15; 15(4):1771-9. PMID: 17166725; PMCID: PMC1810563.
      27. Choo H, Beadle J, Kern ER, Prichard MN, Keith KA, Hartline CB, Trahan J, Aldern KA, Korba BE, Hostetler KY. Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters. Antimicrob Agents Chemother. 2007 Feb; 51(2):611-5. PMID: 17130297; PMCID: PMC1797766.
      28. Hostetler KY, Beadle J, Trahan J, Aldern KA, Owens G, Schriewer J, Melman L, Buller RM. Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice. Antiviral Res. 2007 Mar; 73(3):212-8. PMID: 17123638; PMCID: PMC1859865.
      29. Ruiz JC, Beadle J, Aldern KA, Keith KA, Hartline CB, Kern ER, Hostetler KY. Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir. Antiviral Res. 2007 Jul; 75(1):87-90. PMID: 17367874; PMCID: PMC1899528.
      30. Hostetler KY, Aldern KA, Wan WB, Ciesla SL, Beadle J. Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro. Antimicrob Agents Chemother. 2006 Aug; 50(8):2857-9. PMID: 16870786; PMCID: PMC1538655.
      31. Lebeau I, Andrei G, Dal Pozzo F, Beadle J, Hostetler KY, De Clercq E, van den Oord J, Snoeck R. Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures. Antimicrob Agents Chemother. 2006 Jul; 50(7):2525-9. PMID: 16801436; PMCID: PMC1489770.
      32. Valiaeva N, Beadle J, Aldern KA, Trahan J, Hostetler KY. Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro. Antiviral Res. 2006 Oct; 72(1):10-9. PMID: 16630664.
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      33. Beadle J, Wan WB, Ciesla SL, Keith KA, Hartline C, Kern ER, Hostetler KY. Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses. J Med Chem. 2006 Mar 23; 49(6):2010-5. PMID: 16539388.
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      34. Ruiz JC, Aldern KA, Beadle J, Hartline CB, Kern ER, Hostetler KY. Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine. Antivir Chem Chemother. 2006; 17(2):89-95. PMID: 17042330.
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      35. Hostetler KY, Rought S, Aldern KA, Trahan J, Beadle J, Corbeil J. Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro. Mol Cancer Ther. 2006 Jan; 5(1):156-9. PMID: 16432174.
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      36. Williams-Aziz SL, Hartline CB, Harden EA, Daily SL, Prichard MN, Kushner NL, Beadle J, Wan WB, Hostetler KY, Kern ER. Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro. Antimicrob Agents Chemother. 2005 Sep; 49(9):3724-33. PMID: 16127046; PMCID: PMC1195409.
      37. Lu S, Cheng L, Hostetler KY, Koh HJ, Beadle J, Davidson MC, Freeman WR. Intraocular properties of hexadecyloxypropyl-cyclic-cidofovir in Guinea pigs. J Ocul Pharmacol Ther. 2005 Jun; 21(3):205-9. PMID: 15969637.
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      38. Wan WB, Beadle J, Hartline C, Kern ER, Ciesla SL, Valiaeva N, Hostetler KY. Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro. Antimicrob Agents Chemother. 2005 Feb; 49(2):656-62. PMID: 15673748; PMCID: PMC547274.
      39. Hartline CB, Gustin KM, Wan WB, Ciesla SL, Beadle J, Hostetler KY, Kern ER. Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro. J Infect Dis. 2005 Feb 01; 191(3):396-9. PMID: 15633099.
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      40. Cheng L, Hostetler KY, Lee J, Koh HJ, Beadle J, Bessho K, Toyoguchi M, Aldern K, Bovet JM, Freeman WR. Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4138-44. PMID: 15505067; PMCID: PMC2666013.
      41. Kern ER, Collins DJ, Wan WB, Beadle J, Hostetler KY, Quenelle DC. Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir. Antimicrob Agents Chemother. 2004 Sep; 48(9):3516-22. PMID: 15328119; PMCID: PMC514741.
      42. Bidanset DJ, Beadle J, Wan WB, Hostetler KY, Kern ER. Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection. J Infect Dis. 2004 Aug 01; 190(3):499-503. PMID: 15243923.
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      43. Keith KA, Wan WB, Ciesla SL, Beadle J, Hostetler KY, Kern ER. Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro. Antimicrob Agents Chemother. 2004 May; 48(5):1869-71. PMID: 15105146; PMCID: PMC400568.
      44. Smee DF, Wong MH, Bailey KW, Beadle J, Hostetler KY, Sidwell RW. Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice. Int J Antimicrob Agents. 2004 May; 23(5):430-7. PMID: 15120719.
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      45. Quenelle DC, Collins DJ, Wan WB, Beadle J, Hostetler KY, Kern ER. Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir. Antimicrob Agents Chemother. 2004 Feb; 48(2):404-12. PMID: 14742188; PMCID: PMC321539.
      46. Buller RM, Owens G, Schriewer J, Melman L, Beadle J, Hostetler KY. Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model. Virology. 2004 Jan 20; 318(2):474-81. PMID: 14972516.
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      47. Ciesla SL, Trahan J, Wan WB, Beadle J, Aldern KA, Painter GR, Hostetler KY. Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney. Antiviral Res. 2003 Aug; 59(3):163-71. PMID: 12927306.
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      48. Cheng L, Hostetler KY, Toyoguchi M, Beadle J, Rodanant N, Gardner MF, Aldern KA, Bergeron-Lynn G, Freeman WR. Ganciclovir release rates in vitreous from different formulations of 1-O-hexadecylpropanediol-3-phospho-ganciclovir. J Ocul Pharmacol Ther. 2003 Apr; 19(2):161-9. PMID: 12804061.
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      49. Beadle J, Hartline C, Aldern KA, Rodriguez N, Harden E, Kern ER, Hostetler KY. Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro. Antimicrob Agents Chemother. 2002 Aug; 46(8):2381-6. PMID: 12121908; PMCID: PMC127379.
      50. Kern ER, Hartline C, Harden E, Keith K, Rodriguez N, Beadle J, Hostetler KY. Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir. Antimicrob Agents Chemother. 2002 Apr; 46(4):991-5. PMID: 11897580; PMCID: PMC127114.
      51. Cheng L, Hostetler KY, Chaidhawangul S, Gardner MF, Beadle J, Toyoguchi M, Bergeron-Lynn G, Freeman WR. Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):515-21. PMID: 11818399.
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      52. Hammond JL, Koontz DL, Bazmi HZ, Beadle J, Hostetler SE, Kini GD, Aldern KA, Richman DD, Hostetler KY, Mellors JW. Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistance. Antimicrob Agents Chemother. 2001 Jun; 45(6):1621-8. PMID: 11353603; PMCID: PMC90523.
      53. Hostetler KY, Rybak RJ, Beadle J, Gardner MF, Aldern KA, Wright KN, Kern ER. In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections. Antivir Chem Chemother. 2001 Jan; 12(1):61-70. PMID: 11437323.
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      54. Hostetler KY, Beadle J, Hornbuckle WE, Bellezza CA, Tochkov IA, Cote PJ, Gerin JL, Korba BE, Tennant BC. Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2000 Jul; 44(7):1964-9. PMID: 10858362; PMCID: PMC89993.
      55. Cheng L, Hostetler KY, Chaidhawangul S, Gardner MF, Beadle J, Keefe KS, Bergeron-Lynn G, Severson GM, Soules KA, Mueller AJ, Freeman WR. Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1523-32. PMID: 10798672.
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      56. Hostetler KY, Hammond JL, Kini GD, Hostetler SE, Beadle J, Aldern KA, Chou TC, Richman DD, Mellors JW. In vitro anti-HIV-1 activity of sn-2-substituted 1-O-octadecyl-sn-glycero-3-phosphonoformate analogues and synergy with zidovudine. Antivir Chem Chemother. 2000 May; 11(3):213-9. PMID: 10901292.
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      57. Beadle J, Kini GD, Aldern KA, Gardner MF, Wright KN, Rybak RJ, Kern ER, Hostetler KY. Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice. Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb; 19(1-2):471-9. PMID: 10772728.
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      58. Cheng L, Hostetler KY, Gardner MF, Avila CP, Bergeron-Lynn G, Keefe KS, Beadle J, Wiley CA, Freeman WR. Intravitreal toxicology and therapeutic efficacy of the carboxymethyl ester of the 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA-O-Me), a novel lipid antiviral prodrug for intraocular drug delivery. J Ocul Pharmacol Ther. 1999 Aug; 15(4):363-77. PMID: 10463875.
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      59. Beadle J, Kini GD, Aldern KA, Gardner MF, Wright KN, Richman DD, Hostetler KY. Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and human immunodeficiency virus type 1-infected cells. Antivir Chem Chemother. 1998 Jan; 9(1):33-40. PMID: 9875375.
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      60. Kini GD, Hostetler SE, Beadle J, Aldern KA. Synthesis and antiviral activity of 1-O-octadecyl-2-O-alkyl-sn-glycero-3-foscarnet conjugates in human cytomegalovirus-infected cells. Antiviral Res. 1997 Nov; 36(2):115-24. PMID: 9443668.
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      61. Kini GD, Beadle J, Xie H, Aldern KA, Richman DD, Hostetler KY. Alkoxy propane prodrugs of foscarnet: effect of alkyl chain length on in vitro antiviral activity in cells infected with HIV-1, HSV-1 and HCMV. Antiviral Res. 1997 Sep; 36(1):43-53. PMID: 9330760.
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      62. Hostetler KY, Beadle J, Kini GD, Gardner MF, Wright KN, Wu TH, Korba BA. Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro. Biochem Pharmacol. 1997 Jun 15; 53(12):1815-22. PMID: 9256156.
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      63. Hostetler KY, Kini GD, Beadle J, Aldern KA, Gardner MF, Border R, Kumar R, Barshak L, Sridhar CN, Wheeler CJ, Richman DD. Lipid prodrugs of phosphonoacids: greatly enhanced antiviral activity of 1-O-octadecyl-sn-glycero-3-phosphonoformate in HIV-1, HSV-1 and HCMV-infected cells, in vitro. Antiviral Res. 1996 Jun; 31(1-2):59-67. PMID: 8793009.
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