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Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Dec 28; 49(26):7807-15.
Allan AL, Gladstone PL, Price ML, Hopkins SA, Juarez JC, Doñate F, Ternansky RJ, Shaw DE, Ganem B, Li Y, Wang W, Ealick S. PMID: 17181163.
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5 Fields:
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HumansCells
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First-in-class pan caspase inhibitor developed for the treatment of liver disease. J Med Chem. 2005 Nov 03; 48(22):6779-82.
Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD, Fritz LC, Gladstone P, Groessl T, Gu X, Herrmann J, Hirakawa BP, Hoglen NC, Jahangiri KG, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs J, McQuiston J, Meduna SP, Nalley K, Robinson ED, Sayers RO, Sebring K, Spada AP, Ternansky RJ, Tomaselli KJ, Ullman BR, Valentino KL, Weeks S, Winn D, Wu JC, Yeo P, Zhang CZ. PMID: 16250635.
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30 Fields:
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HumansAnimalsCells
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Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads. Bioorg Med Chem Lett. 2005 Aug 01; 15(15):3632-6.
Ullman BR, Aja T, Chen N, Diaz JL, Gu X, Herrmann J, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs JJ, Linton SD, Meduna SP, Nalley K, Robinson ED, Roggo SP, Sayers RO, Schmitz A, Ternansky RJ, Tomaselli KJ, Wu JC. PMID: 15964758.
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3 Fields:
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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke. Bioorg Med Chem Lett. 2004 May 17; 14(10):2685-91.
Linton SD, Aja T, Allegrini PR, Deckwerth TL, Diaz JL, Hengerer B, Herrmann J, Jahangiri KG, Kallen J, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo S, Rovelli G, Sauter A, Sayers RO, Schmitz A, Smidt R, Ternansky RJ, Tomaselli KJ, Ullman BR, Wiessner C, Wu JC. PMID: 15109679.
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5 Fields:
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Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3623-6.
Ullman BR, Aja T, Deckwerth TL, Diaz JL, Herrmann J, Kalish VJ, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo SP, Sayers RO, Schmitz A, Ternansky RJ, Tomaselli KJ, Wu JC. PMID: 14505683.
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3 Fields:
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Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model. Bioorg Med Chem Lett. 2003 Jan 06; 13(1):107-10.
Price ML, Guida WC, Jackson TE, Nydick JA, Gladstone PL, Juarez JC, Doñate F, Ternansky RJ. PMID: 12467627.
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Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorg Med Chem Lett. 2002 Oct 21; 12(20):2973-5.
Linton SD, Karanewsky DS, Ternansky RJ, Chen N, Guo X, Jahangiri KG, Kalish VJ, Meduna SP, Robinson ED, Ullman BR, Wu JC, Pham B, Kodandapani L, Smidt R, Diaz JL, Fritz LC, von Krosigk U, Roggo S, Schmitz A, Tomaselli KJ. PMID: 12270186.
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3 Fields:
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Cells
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Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization. Bioorg Med Chem Lett. 2002 Oct 21; 12(20):2969-71.
Linton SD, Karanewsky DS, Ternansky RJ, Wu JC, Pham B, Kodandapani L, Smidt R, Diaz JL, Fritz LC, Tomaselli KJ. PMID: 12270185.
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4 Fields:
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Cells
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The structure-activity relationships of a series of suicide inhibitors of phospholipase A2. Bioorg Med Chem Lett. 1998 Aug 18; 8(16):2129-32.
Yu L, Ternansky RJ, Victoria EJ, Chang J, Coutts SM. PMID: 9873499.
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AnimalsCells
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Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs. J Med Chem. 1996 Oct 11; 39(21):4261-74.
Cantrell AS, Engelhardt P, Högberg M, Jaskunas SR, Johansson NG, Jordan CL, Kangasmetsä J, Kinnick MD, Lind P, Morin JM, Muesing MA, Noreén R, Oberg B, Pranc P, Sahlberg C, Ternansky RJ, Vasileff RT, Vrang L, West SJ, Zhang H. PMID: 8863804.
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10 Fields:
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AnimalsCells
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Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 1. Effect of nuclear modification on in vitro activity. J Med Chem. 1993 Oct 29; 36(22):3219-23.
Ternansky RJ, Draheim SE. PMID: 8230111.
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Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 2. Effect of side-chain modification on in vitro activity and pharmacokinetic parameters. J Med Chem. 1993 Oct 29; 36(22):3224-9.
Ternansky RJ, Draheim SE, Pike AJ, Counter FT, Eudaly JA, Kasher JS. PMID: 8230112.
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5 Fields:
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Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. J Med Chem. 1993 Jul 09; 36(14):1971-6.
Ternansky RJ, Draheim SE, Pike AJ, Bell FW, West SJ, Jordan CL, Wu CY, Preston DA, Albron W, Kasher JS, et al. PMID: 8336336.
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HumansAnimalsCells