Scott Sternson

Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-0835-444X Additional info
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    Collapse Biography 
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    Rockefeller UniversityPostsdoc12/2006Neurobiology, Molecular Genetics
    Harvard UniversityPh.D.5/2001Chemistry and Chemical Biology
    Bowdoin CollegeB.A.5/1996Chemistry

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    Collapse Overview
    Our laboratory investigates the neural and molecular mechanisms underlying physiological need states, such as hunger and thirst. We want to understand how motivations are produced by the brain while addressing pressing public health problems of obesity, overeating, and addiction. To bridge the gap between research in model organisms and human disease, we integrate molecular technologies with system neuroscience and develop new chemogenetic technologies.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neuroscience: Neurons that use a stress hormone increase eating. Curr Biol. 2023 12 18; 33(24):R1296-R1298. Zhu Z, Sternson SM. PMID: 38113842.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Neurobiology of eating behavior, nutrition, and health. J Intern Med. 2023 Nov; 294(5):582-604. Stover PJ, Field MS, Andermann ML, Bailey RL, Batterham RL, Cauffman E, Frühbeck G, Iversen PO, Starke-Reed P, Sternson SM, Vinoy S, Witte AV, Zuker CS, Angelin B. PMID: 37424220.
      View in: PubMed   Mentions: 4     Fields:    
    3. Multimodal mapping of cell types and projections in the central nucleus of the amygdala. Elife. 2023 01 20; 12. Wang Y, Krabbe S, Eddison M, Henry FE, Fleishman G, Lemire AL, Wang L, Korff W, Tillberg PW, Lüthi A, Sternson SM. PMID: 36661218; PMCID: PMC9977318.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    4. Characterization of Ultrapotent Chemogenetic Ligands for Research Applications in Nonhuman Primates. ACS Chem Neurosci. 2022 11 02; 13(21):3118-3125. Raper J, Eldridge MAG, Sternson SM, Shim JY, Fomani GP, Richmond BJ, Wichmann T, Galvan A. PMID: 36279419; PMCID: PMC9910343.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Exercise molecule burns away hunger. Nature. 2022 06; 606(7915):655-656. Kim T, Sternson SM. PMID: 35705863.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. EASI-FISH for thick tissue defines lateral hypothalamus spatio-molecular organization. Cell. 2021 12 22; 184(26):6361-6377.e24. Wang Y, Eddison M, Fleishman G, Weigert M, Xu S, Wang T, Rokicki K, Goina C, Henry FE, Lemire AL, Schmidt U, Yang H, Svoboda K, Myers EW, Saalfeld S, Korff W, Sternson SM, Tillberg PW. PMID: 34875226.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    7. Hunger or thirst state uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making. Nat Neurosci. 2021 07; 24(7):907-912. Eiselt AK, Chen S, Chen J, Arnold J, Kim T, Pachitariu M, Sternson SM. PMID: 33972802; PMCID: PMC8254795.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    8. Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles. Science. 2020 10 16; 370(6514). Xu S, Yang H, Menon V, Lemire AL, Wang L, Henry FE, Turaga SC, Sternson SM. PMID: 33060330.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    9. Exploring internal state-coding across the rodent brain. Curr Opin Neurobiol. 2020 12; 65:20-26. Sternson SM. PMID: 32950827.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption. Cell. 2020 09 17; 182(6):1589-1605.e22. Gong R, Xu S, Hermundstad A, Yu Y, Sternson SM. PMID: 32841600.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    11. Seeing the forest for the trees in obesity. Nat Metab. 2020 08; 2(8):661-662. Sternson SM. PMID: 32719539.
      View in: PubMed   Mentions: 1     Fields:    
    12. Chemogenetics: drug-controlled gene therapies for neural circuit disorders. Cell Gene Ther Insights. 2020 Aug; 6(7):1079-1094. Sternson SM, Bleakman D. PMID: 34422319; PMCID: PMC8376173.
      View in: PubMed   Mentions: 5  
    13. Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain. Cell. 2019 09 19; 179(1):268-281.e13. Winnubst J, Bas E, Ferreira TA, Wu Z, Economo MN, Edson P, Arthur BJ, Bruns C, Rokicki K, Schauder D, Olbris DJ, Murphy SD, Ackerman DG, Arshadi C, Baldwin P, Blake R, Elsayed A, Hasan M, Ramirez D, Dos Santos B, Weldon M, Zafar A, Dudman JT, Gerfen CR, Hantman AW, Korff W, Sternson SM, Spruston N, Svoboda K, Chandrashekar J. PMID: 31495573; PMCID: PMC6754285.
      View in: PubMed   Mentions: 189     Fields:    Translation:AnimalsCells
    14. Ultrapotent chemogenetics for research and potential clinical applications. Science. 2019 04 12; 364(6436). Magnus CJ, Lee PH, Bonaventura J, Zemla R, Gomez JL, Ramirez MH, Hu X, Galvan A, Basu J, Michaelides M, Sternson SM. PMID: 30872534; PMCID: PMC7252514.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    15. Chemogenetic Tools for Causal Cellular and Neuronal Biology. Physiol Rev. 2018 01 01; 98(1):391-418. Atasoy D, Sternson SM. PMID: 29351511; PMCID: PMC5866359.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    16. Raphe Circuits on the Menu. Cell. 2017 07 27; 170(3):409-410. Yang H, Sternson SM. PMID: 28753420.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Three Pillars for the Neural Control of Appetite. Annu Rev Physiol. 2017 02 10; 79:401-423. Sternson SM, Eiselt AK. PMID: 27912679.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimals
    18. Near-Perfect Synaptic Integration by Nav1.7 in Hypothalamic Neurons Regulates Body Weight. Cell. 2016 Jun 16; 165(7):1749-1761. Branco T, Tozer A, Magnus CJ, Sugino K, Tanaka S, Lee AK, Wood JN, Sternson SM. PMID: 27315482; PMCID: PMC4912688.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    19. An Emerging Technology Framework for the Neurobiology of Appetite. Cell Metab. 2016 Feb 09; 23(2):234-53. Sternson SM, Atasoy D, Betley JN, Henry FE, Xu S. PMID: 26724860.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    20. Applying the Brakes: When to Stop Eating. Neuron. 2015 Nov 04; 88(3):440-1. Betley JN, Sternson SM. PMID: 26539885.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    21. Hunger: The carrot and the stick. Mol Metab. 2016 Jan; 5(1):1-2. Sternson SM. PMID: 26844201; PMCID: PMC4703830.
      View in: PubMed   Mentions: 5     Fields:    
    22. Cell type-specific pharmacology of NMDA receptors using masked MK801. Elife. 2015 Sep 11; 4. Yang Y, Lee P, Sternson SM. PMID: 26359633; PMCID: PMC4594264.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss. Elife. 2015 Sep 02; 4. Henry FE, Sugino K, Tozer A, Branco T, Sternson SM. PMID: 26329458; PMCID: PMC4595745.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    24. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat Neurosci. 2015 Sep; 18(9):1202-12. Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI. PMID: 26308981.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    25. Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature. 2015 May 14; 521(7551):180-185. Betley JN, Xu S, Cao ZFH, Gong R, Magnus CJ, Yu Y, Sternson SM. PMID: 25915020; PMCID: PMC4567040.
      View in: PubMed   Mentions: 311     Fields:    Translation:AnimalsCells
    26. Leptin mediates the increase in blood pressure associated with obesity. Cell. 2014 Dec 04; 159(6):1404-16. Simonds SE, Pryor JT, Ravussin E, Greenway FL, Dileone R, Allen AM, Bassi J, Elmquist JK, Keogh JM, Henning E, Myers MG, Licinio J, Brown RD, Enriori PJ, O'Rahilly S, Sternson SM, Grove KL, Spanswick DC, Farooqi IS, Cowley MA. PMID: 25480301; PMCID: PMC4259491.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    27. Agouti-related protein neuron circuits that regulate appetite. Neuroendocrinology. 2014; 100(2-3):95-102. Sternson SM, Atasoy D. PMID: 25402352.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    28. A genetically specified connectomics approach applied to long-range feeding regulatory circuits. Nat Neurosci. 2014 Dec; 17(12):1830-9. Atasoy D, Betley JN, Li WP, Su HH, Sertel SM, Scheffer LK, Simpson JH, Fetter RD, Sternson SM. PMID: 25362474; PMCID: PMC4292906.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    29. Chemogenetic tools to interrogate brain functions. Annu Rev Neurosci. 2014; 37:387-407. Sternson SM, Roth BL. PMID: 25002280.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansAnimalsCells
    30. Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior. Neuron. 2014 May 21; 82(4):797-808. Stachniak TJ, Ghosh A, Sternson SM. PMID: 24768300; PMCID: PMC4306349.
      View in: PubMed   Mentions: 208     Fields:    Translation:HumansAnimalsCells
    31. Parallel, redundant circuit organization for homeostatic control of feeding behavior. Cell. 2013 Dec 05; 155(6):1337-50. Betley JN, Cao ZF, Ritola KD, Sternson SM. PMID: 24315102; PMCID: PMC3970718.
      View in: PubMed   Mentions: 285     Fields:    Translation:AnimalsCells
    32. Neural circuits and motivational processes for hunger. Curr Opin Neurobiol. 2013 Jun; 23(3):353-60. Sternson SM, Nicholas Betley J, Cao ZF. PMID: 23648085; PMCID: PMC3948161.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    33. Hypothalamic survival circuits: blueprints for purposive behaviors. Neuron. 2013 Mar 06; 77(5):810-24. Sternson SM. PMID: 23473313; PMCID: PMC4306350.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    34. Deconstruction of a neural circuit for hunger. Nature. 2012 Aug 09; 488(7410):172-7. Atasoy D, Betley JN, Su HH, Sternson SM. PMID: 22801496; PMCID: PMC3416931.
      View in: PubMed   Mentions: 467     Fields:    Translation:AnimalsCells
    35. Selective esterase-ester pair for targeting small molecules with cellular specificity. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4756-61. Tian L, Yang Y, Wysocki LM, Arnold AC, Hu A, Ravichandran B, Sternson SM, Looger LL, Lavis LD. PMID: 22411832; PMCID: PMC3323987.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    36. Neuron transplantation partially reverses an obesity disorder in mice. Cell Metab. 2012 Feb 08; 15(2):133-4. Sternson SM. PMID: 22326215.
      View in: PubMed   Mentions: 1     Fields:    
    37. Regulation of neuronal input transformations by tunable dendritic inhibition. Nat Neurosci. 2012 Jan 15; 15(3):423-30, S1-3. Lovett-Barron M, Turi GF, Kaifosh P, Lee PH, Bolze F, Sun XH, Nicoud JF, Zemelman BV, Sternson SM, Losonczy A. PMID: 22246433.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    38. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell. 2011 Sep 16; 146(6):992-1003. Yang Y, Atasoy D, Su HH, Sternson SM. PMID: 21925320; PMCID: PMC3209501.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    39. Metabolism: Let them eat fat. Nature. 2011 Sep 07; 477(7363):166-7. Sternson SM. PMID: 21901003.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    40. Chemical and genetic engineering of selective ion channel-ligand interactions. Science. 2011 Sep 02; 333(6047):1292-6. Magnus CJ, Lee PH, Atasoy D, Su HH, Looger LL, Sternson SM. PMID: 21885782; PMCID: PMC3210548.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    41. Adeno-associated viral vectors for mapping, monitoring, and manipulating neural circuits. Hum Gene Ther. 2011 Jun; 22(6):669-77. Betley JN, Sternson SM. PMID: 21319997; PMCID: PMC3107581.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    42. Automatic reconstruction of 3D neuron structures using a graph-augmented deformable model. Bioinformatics. 2010 Jun 15; 26(12):i38-46. Peng H, Ruan Z, Atasoy D, Sternson S. PMID: 20529931; PMCID: PMC2881396.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    43. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat Neurosci. 2011 Mar; 14(3):351-5. Aponte Y, Atasoy D, Sternson SM. PMID: 21209617; PMCID: PMC3049940.
      View in: PubMed   Mentions: 553     Fields:    Translation:AnimalsCells
    44. Leptin targets in the mouse brain. J Comp Neurol. 2009 Jun 10; 514(5):518-32. Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM, Elmquist JK. PMID: 19350671; PMCID: PMC2710238.
      View in: PubMed   Mentions: 254     Fields:    Translation:Animals
    45. The subcellular organization of neocortical excitatory connections. Nature. 2009 Feb 26; 457(7233):1142-5. Petreanu L, Mao T, Sternson SM, Svoboda K. PMID: 19151697; PMCID: PMC2745650.
      View in: PubMed   Mentions: 564     Fields:    Translation:AnimalsCells
    46. A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping. J Neurosci. 2008 Jul 09; 28(28):7025-30. Atasoy D, Aponte Y, Su HH, Sternson SM. PMID: 18614669; PMCID: PMC2593125.
      View in: PubMed   Mentions: 386     Fields:    Translation:HumansAnimalsCells
    47. Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci. 2005 Oct; 8(10):1356-63. Sternson SM, Shepherd GM, Friedman JM. PMID: 16172601.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    48. Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes. Chem Biol. 2004 Sep; 11(9):1279-91. Wong JC, Sternson SM, Louca JB, Hong R, Schreiber SL. PMID: 15380188.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    49. Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature. 2002 Apr 11; 416(6881):653-7. Kuruvilla FG, Shamji AF, Sternson SM, Hergenrother PJ, Schreiber SL. PMID: 11948353.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    50. Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin. Org Lett. 2001 Dec 27; 3(26):4239-42. Sternson SM, Wong JC, Grozinger CM, Schreiber SL. PMID: 11784187.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    51. Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays. J Am Chem Soc. 2001 Feb 28; 123(8):1740-7. Sternson SM, Louca JB, Wong JC, Schreiber SL. PMID: 11456775.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
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