Our site may be slower due to heavy traffic from automated "bots" and AI crawlers. We're working to fix this.

Harrison Penrose

Photo of Harrison Penrose
Title(s)RESID PHYS/SUBSPEC 4-8/REP, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    UC San DiegoFellowshipGastroenterology (PSTP)
    UC San DiegoInternship & Residency2023Internal Medicine (PSTP)
    Tulane MD, PhD2021Medicine
    UC San DiegoBS, MS2012Biochemistry & Cell Biology

    Collapse Overview 

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Living Organoid Biobank of Crohn's Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes. medRxiv. 2025 Jul 09. Penrose HM, Sinha S, Tindle C, Zablan K, Le HN, Neill J, Ghosh P, Boland BS. PMID: 40236416; PMCID: PMC11998810.
      View in: PubMed   Mentions:
    2. F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery. bioRxiv. 2025 Apr 30. Sinha S, McLaren E, Mullick M, Penrose HM, Tindle C, Singh S, Boland BS, Ghosh P. PMID: 39071297; PMCID: PMC11275938.
      View in: PubMed   Mentions:
    3. Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels. Gastroenterology. 2025 Feb; 168(2):286-299.e6. Ghimire J, Collins ME, Snarski P, King AN, Ruiz E, Iftikhar R, Penrose HM, Moroz K, Rorison T, Baddoo M, Naeem MA, Zea AH, Magness ST, Flemington EF, Crawford SE, Savkovic SD. PMID: 39299402.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. FOXO3 Deficiency in Neutrophils Drives Colonic Inflammation and Tumorigenesis. Int J Mol Sci. 2023 Jun 04; 24(11). Ghimire J, Iftikhar R, Penrose HM, Snarski P, Ruiz E, Savkovic SD. PMID: 37298680; PMCID: PMC10253470.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn's Disease but Not Ulcerative Colitis Patients. Pharmaceutics. 2023 Mar 02; 15(3). Park YS, Kang SB, Marchelletta RR, Penrose HM, Ruiter-Visser R, Jung B, Docherty MJ, Boland BS, Sandborn WJ, McCole DF. PMID: 36986672; PMCID: PMC10053841.
      View in: PubMed   Mentions: 6  
    6. FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis. Metabolites. 2022 Mar 16; 12(3). Iftikhar R, Penrose HM, King AN, Kim Y, Ruiz E, Kandil E, Machado HL, Savkovic SD. PMID: 35323693; PMCID: PMC8949544.
      View in: PubMed   Mentions: 8  
    7. Correction: Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity. Oncogenesis. 2022 Mar 15; 11(1):14. Iftikhar R, Penrose HM, King AN, Samudre JS, Collins ME, Hartono AB, Lee SB, Lau F, Baddoo M, Flemington EF, Crawford SE, Savkovic SD. PMID: 35292620; PMCID: PMC8924151.
      View in: PubMed   Mentions:
    8. Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity. Oncogenesis. 2021 Nov 29; 10(11):82. Iftikhar R, Penrose HM, King AN, Samudre JS, Collins ME, Hartono AB, Lee SB, Lau F, Baddoo M, Flemington EF, Crawford SE, Savkovic SD. PMID: 34845203; PMCID: PMC8630180.
      View in: PubMed   Mentions: 16  
    9. Trends in the Incidence of Early-Onset Colorectal Adenocarcinoma Among Black and White US Residents Aged 40 to 49 Years, 2000-2017. JAMA Netw Open. 2021 11 01; 4(11):e2130433. Montminy EM, Zhou M, Maniscalco L, Penrose H, Yen T, Patel SG, Wu XC, Karlitz JJ. PMID: 34751760; PMCID: PMC8579235.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    10. Ulcerative colitis immune cell landscapes and differentially expressed gene signatures determine novel regulators and predict clinical response to biologic therapy. Sci Rep. 2021 04 27; 11(1):9010. Penrose HM, Iftikhar R, Collins ME, Toraih E, Ruiz E, Ungerleider N, Nakhoul H, Flemington EF, Kandil E, Shah SB, Savkovic SD. PMID: 33907256; PMCID: PMC8079702.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    11. STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells. J Renin Angiotensin Aldosterone Syst. 2020 Jul-Sep; 21(3):1470320320946527. Penrose HM, Katsurada A, Miyata K, Urushihara M, Satou R. PMID: 32741247; PMCID: PMC7412908.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Bacterial TLR4 and NOD2 signaling linked to reduced mitochondrial energy function in active inflammatory bowel disease. Gut Microbes. 2020 05 03; 11(3):350-363. Ruiz E, Penrose HM, Heller S, Nakhoul H, Baddoo M, Flemington EF, Kandil E, Savkovic SD. PMID: 31063017; PMCID: PMC7524318.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    13. Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets. Cell Mol Gastroenterol Hepatol. 2019; 7(2):391-408. Penrose HM, Cable C, Heller S, Ungerleider N, Nakhoul H, Baddoo M, Hartono AB, Lee SB, Burow ME, Flemington EF, Crawford SE, Savkovic SD. PMID: 30718226; PMCID: PMC6360252.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    14. Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure. Curr Hypertens Rep. 2018 10 05; 20(12):100. Satou R, Penrose H, Navar LG. PMID: 30291560; PMCID: PMC6203444.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    15. In colonic ρ0 (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer. Oncoscience. 2017 Nov; 4(11-12):189-198. Penrose HM, Heller S, Cable C, Nakhoul H, Ungerleider N, Baddoo M, Pursell ZF, Flemington EK, Crawford SE, Savkovic SD. PMID: 29344557; PMCID: PMC5769983.
      View in: PubMed   Mentions: 7  
    16. High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. Carcinogenesis. 2017 03 01; 38(3):302-311. Penrose HM, Heller S, Cable C, Nakhoul H, Baddoo M, Flemington E, Crawford SE, Savkovic SD. PMID: 28426873; PMCID: PMC5862315.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    17. Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation. FASEB J. 2017 05; 31(5):2013-2025. Heller S, Penrose HM, Cable C, Biswas D, Nakhoul H, Baddoo M, Flemington E, Crawford SE, Savkovic SD. PMID: 28183804; PMCID: PMC5388551.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    18. VSL#3 Probiotic Stimulates T-cell Protein Tyrosine Phosphatase-mediated Recovery of IFN-γ-induced Intestinal Epithelial Barrier Defects. Inflamm Bowel Dis. 2016 12; 22(12):2811-2823. Krishnan M, Penrose HM, Shah NN, Marchelletta RR, McCole DF. PMID: 27824650; PMCID: PMC5779620.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    19. Macrophage-derived IL-6 contributes to ANG II-mediated angiotensinogen stimulation in renal proximal tubular cells. Am J Physiol Renal Physiol. 2016 05 15; 310(10):F1000-7. O'Leary R, Penrose H, Miyata K, Satou R. PMID: 27009340; PMCID: PMC4983453.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets. Am J Physiol Gastrointest Liver Physiol. 2016 05 15; 310(10):G844-54. Heller S, Cable C, Penrose H, Makboul R, Biswas D, Cabe M, Crawford SE, Savkovic SD. PMID: 26968210; PMCID: PMC4895869.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    21. Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6. Biochem Biophys Res Commun. 2016 Jan 15; 469(3):370-6. Penrose H, Heller S, Cable C, Makboul R, Chadalawada G, Chen Y, Crawford SE, Savkovic SD. PMID: 26657850; PMCID: PMC5607009.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    22. A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa. Pharmacol Res Perspect. 2015 Mar; 3(2):e00128. Kang SB, Marchelletta RR, Penrose H, Docherty MJ, McCole DF. PMID: 26038704; PMCID: PMC4448989.
      View in: PubMed   Mentions: 2     Fields:    
    23. Spermidine stimulates T cell protein-tyrosine phosphatase-mediated protection of intestinal epithelial barrier function. J Biol Chem. 2013 Nov 08; 288(45):32651-32662. Penrose HM, Marchelletta RR, Krishnan M, McCole DF. PMID: 24022492; PMCID: PMC3820900.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    Harrison's Networks
    Concepts (112)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (6)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (59)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-16-gff1bd585 on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California