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    William Hardison

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #9111D
    CA La Jolla 92093
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      BILE ACID EFFECTS ON THE LIVER AND BILIARY TREE
      NIH/NIDDK R01DK028446Apr 1, 1981 - Aug 30, 1996
      Role: Principal Investigator
      BILE ACID EFFECTS ON THE LIVER AND BILIARY TREE
      NIH/NIADDK R01AM028446Apr 1, 1981 - Nov 30, 1987
      Role: Principal Investigator

      Collapse Bibliographic 
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Atina JO, Ogutu EO, Hardison W, Mumo J. Prevalence of hepatitis A, B, C and human immunodeficiency virus seropositivity among patients with acute icteric hepatitis at the Kenyatta National Hospital, Nairobi. East Afr Med J. 2004 Apr; 81(4):183-7. PMID: 15884283.
        View in: PubMed
      2. Gunn RA, Murray PJ, Ackers ML, Hardison W, Margolis HS. Screening for chronic hepatitis B and C virus infections in an urban sexually transmitted disease clinic: rationale for integrating services. Sex Transm Dis. 2001 Mar; 28(3):166-70. PMID: 11289199.
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      3. Poucell-Hatton S, Perkins PS, Deerinck TJ, Ellisman MH, Hardison W, Pandol SJ. Myosin I is associated with zymogen granule membranes in the rat pancreatic acinar cell. Gastroenterology. 1997 Aug; 113(2):649-58. PMID: 9247487.
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      4. Hardison W. I've been where it's gone, so I know what I got ... An American Fulbright Lecturer in Albania, 1994-1995. Ann Intern Med. 1996 Nov 15; 125(10):835-8. PMID: 8928991.
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      5. Orloff MJ, Bell RH, Orloff MS, Greenburg AG, Hardison W. Emergency portacaval shunt: a perspective on the perspective. Hepatology. 1995 Apr; 21(4):1203-6. PMID: 7705798.
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      6. Orloff MJ, Bell RH, Orloff MS, Hardison W, Greenburg AG. Prospective randomized trial of emergency portacaval shunt and emergency medical therapy in unselected cirrhotic patients with bleeding varices. Hepatology. 1994 Oct; 20(4 Pt 1):863-72. PMID: 7927227.
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      7. Yamaguchi Y, Dalle-Molle E, Hardison W. Hepatocyte horseradish peroxidase uptake is saturable and inhibited by mannose-terminal glycoproteins. Am J Physiol. 1993 May; 264(5 Pt 1):G880-5. PMID: 8498515.
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      8. Poucell S, Hardison W, Miyai K. Regenerative stimulus increases hepatocyte tight junctional permeability. Hepatology. 1992 Oct; 16(4):1061-8. PMID: 1398486.
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      9. Konno H, Lowe PJ, Hardison W, Miyai K, Nakamura S, Baba S. Breakdown of hepatic tight junctions during reoxygenation injury. Transplantation. 1992 Jun; 53(6):1211-4. PMID: 1604475.
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      10. Yamaguchi Y, Dalle-Molle E, Hardison W. Vasopressin and A23187 stimulate phosphorylation of myosin light chain-1 in isolated rat hepatocytes. Am J Physiol. 1991 Aug; 261(2 Pt 1):G312-9. PMID: 1872400.
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      11. Yamaguchi Y, Hardison W. The pattern of vasopressin-induced reduction in biliary output of cholephilic probes in the rat can be mimicked by dialysis. Hepatology. 1991 Jul; 14(1):175-9. PMID: 2066066.
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      12. Konno H, Hardison W, Miyai K. Reoxygenation injury following anoxic perfusion preferentially impairs bile acid-independent bile flow. Eur Surg Res. 1991; 23(3-4):151-7. PMID: 1782960.
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      13. Hardison W, Dalle-Molle E, Gosink E, Lowe PJ, Steinbach JH, Yamaguchi Y. Function of rat hepatocyte tight junctions: studies with bile acid infusions. Am J Physiol. 1991 Jan; 260(1 Pt 1):G167-74. PMID: 1702935.
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      14. Hardison W, Heasley VL, Shellhamer DF. Specificity of the hepatocyte Na(+)-dependent taurocholate transporter: influence of side chain length and charge. Hepatology. 1991 Jan; 13(1):68-72. PMID: 1988346.
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      15. Ogawa H, Mink J, Hardison W, Miyai K. Alkaline phosphatase activity in hepatic tissue and serum correlates with amount and type of bile acid load. Lab Invest. 1990 Jan; 62(1):87-95. PMID: 2296160.
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      16. Hardison W, Lowe PJ, Shanahan M. Effect of molecular charge on para- and transcellular access of horseradish peroxidase into rat bile. Hepatology. 1989 Jun; 9(6):866-71. PMID: 2714737.
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      17. Anwer MS, Nolan K, Hardison W. Role of bicarbonate in biliary excretion of diisothiocyanostilbene disulfonate. Am J Physiol. 1988 Dec; 255(6 Pt 1):G713-22. PMID: 2849312.
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      18. Lowe PJ, Miyai K, Steinbach JH, Hardison W. Hormonal regulation of hepatocyte tight junctional permeability. Am J Physiol. 1988 Oct; 255(4 Pt 1):G454-61. PMID: 2845804.
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      19. Hardison W, Lowe PJ, Gosink E. Nature of taurodehydrocholic acid uptake in rat hepatocytes. Am J Physiol. 1988 Feb; 254(2 Pt 1):G269-74. PMID: 3348379.
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      20. Baumgartner U, Hardison W, Miyai K. Reduced cholestatic potency of taurolithocholate during backward perfusion of the rat liver. Lab Invest. 1987 Jun; 56(6):576-82. PMID: 3599905.
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      21. Bellentani S, Hardison W, Marchegiano P, Zanasi G, Manenti F. Bile acid inhibition of taurocholate uptake by rat hepatocytes: role of OH groups. Am J Physiol. 1987 Mar; 252(3 Pt 1):G339-44. PMID: 3826374.
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      22. Baumgartner U, Miyai K, Hardison W. Modulation of hepatic biotransformation and biliary excretion of bile acid by age and sinusoidal bile acid load. Am J Physiol. 1987 Jan; 252(1 Pt 1):G114-9. PMID: 3812679.
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      23. Baumgartner U, Miyai K, Hardison W. Greater taurodeoxycholate biotransformation during backward perfusion of rat liver. Am J Physiol. 1986 Oct; 251(4 Pt 1):G431-5. PMID: 3766730.
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      24. Hardison W. Technology illuminates a shadowy syndrome. Gastroenterology. 1986 Jul; 91(1):242-4. PMID: 3710071.
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      25. Steinbach JH, Hardison W. Comparing health care options using the cost-benefit utility ratio. JAMA. 1986 Feb 14; 255(6):747. PMID: 3080613.
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      26. Hardison W, Evans WH. Postobstructive subcellular organelle and biliary lipid composition in the rat. A selective increase in biliary lecithin output is not reflected by changes in organelle composition. J Hepatol. 1986; 3(3):318-27. PMID: 3559141.
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      27. Evans WH, Hardison W. Phospholipid, cholesterol, polypeptide and glycoprotein composition of hepatic endosome subfractions. Biochem J. 1985 Nov 15; 232(1):33-6. PMID: 2867761; PMCID: PMC1152834.
      28. Bellentani S, Hardison W, Manenti F. Mechanisms of liver adaptation to prolonged selective biliary obstruction (SBO) in the rat. J Hepatol. 1985; 1(5):525-35. PMID: 4056353.
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      29. Hardison W, Grundy SM. Effect of ursodeoxycholate and its taurine conjugate on bile acid synthesis and cholesterol absorption. Gastroenterology. 1984 Jul; 87(1):130-5. PMID: 6724255.
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      30. Toyota N, Miyai K, Hardison W. Effect of biliary pressure versus high bile acid flux on the permeability of hepatocellular tight junction. Lab Invest. 1984 May; 50(5):536-42. PMID: 6716970.
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      31. Hardison W, Bellentani S, Heasley V, Shellhamer D. Specificity of an Na+ -dependent taurocholate transport site in isolated rat hepatocytes. Am J Physiol. 1984 May; 246(5 Pt 1):G477-83. PMID: 6720949.
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      32. Bellentani S, Hardison W, Grisendi A, Barbieri I, Manenti F. Bile-acid binding to isolated rat liver plasma membranes. Failure to find a specific binding site. Hoppe Seylers Z Physiol Chem. 1984 Mar; 365(3):357-63. PMID: 6724529.
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      33. Barnhart JL, Witt BL, Hardison W, Berk RN. Uptake of iopanoic acid by isolated rat hepatocytes in primary culture. Am J Physiol. 1983 Jun; 244(6):G630-6. PMID: 6859270.
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      34. Hardison W, Weiner RG, Hatoff DE, Miyai K. Similarities and differences between models of extrahepatic biliary obstruction and complete biliary retention without obstruction in the rat. Hepatology. 1983 May-Jun; 3(3):383-90. PMID: 6840684.
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      35. Hardison W, Grundy SM. Effect of bile acid conjugation pattern on bile acid metabolism in normal humans. Gastroenterology. 1983 Mar; 84(3):617-20. PMID: 6822329.
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      36. Hardison W. Relation of hepatic taurine pool size to bile-acid conjugation in man and animals. Prog Clin Biol Res. 1983; 125:407-17. PMID: 6878417.
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      37. Hatoff DE, Hardison W. Bile acid-dependent secretion of alkaline phosphatase in rat bile. Hepatology. 1982 Jul-Aug; 2(4):433-9. PMID: 7095744.
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      38. Miyai K, Hardison W. Cholestasis induced by scillaren administration, bicarbonate deprivation, or reduced hepatic blood flow. Exp Mol Pathol. 1982 Jun; 36(3):333-46. PMID: 6282620.
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      39. Hardison W, Hatoff DE, Miyai K, Weiner RG. Nature of bile acid maximum secretory rate in the rat. Am J Physiol. 1981 Oct; 241(4):G337-43. PMID: 7315971.
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      40. Lachin JM, Marks JW, Schoenfield LJ, Tyor MP, Bennett PH, Grundy SM, Hardison W, Shaw LW, Thistle JL, Vlahcevic ZR. Design and methodological considerations in the National Cooperative Gallstone Study: a multicenter clinical trial. Control Clin Trials. 1981 Sep; 2(3):177-229. PMID: 7326939.
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      41. Hatoff DE, Hardison W. Bile acids modify alkaline phosphatase induction and bile secretion pressure after bile duct obstruction in the rat. Gastroenterology. 1981 Apr; 80(4):666-72. PMID: 7202938.
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      42. Weisman MH, Hardison W, Walz DT. Studies of the intestinal metabolism of oral gold. J Rheumatol. 1980 Sep-Oct; 7(5):633-8. PMID: 6777493.
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      43. Hardison W, Weiner R. Taurine transport by rat hepatocytes in primary culture. Biochim Biophys Acta. 1980 May 08; 598(1):145-52. PMID: 7417423.
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      44. von Bergmann K, Mok HY, Hardison W, Grundy SM. Cholesterol and bile acid metabolism in moderately advanced, stable cirrhosis of the liver. Gastroenterology. 1979 Dec; 77(6):1183-92. PMID: 499706.
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      45. Einarsson KA, Gundy SM, Hardison W. Enterohepatic circulation rates of cholic acid and chenodeoxycholic acid in man. Gut. 1979 Dec; 20(12):1078-82. PMID: 527882; PMCID: PMC1412833.
      46. Hatoff DE, Hardison W. Induced synthesis of alkaline phosphatase by bile acids in rat liver cell culture. Gastroenterology. 1979 Nov; 77(5):1062-7. PMID: 488632.
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      47. Hardison W. Cirrhosis--treating the ascites and encephalopathy. Med Times. 1979 May; 107(5):23-30. PMID: 449639.
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      48. Hardison W, Tomaszewski N, Grundy SM. Effect of acute alterations in small bowel transit time upon the biliary excretion rate of bile acids. Gastroenterology. 1979 Mar; 76(3):568-74. PMID: 428711.
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      49. Hardison W, Wood CA. Importance of bicarbonate in bile salt independent fraction of bile flow. Am J Physiol. 1978 Aug; 235(2):E158-64. PMID: 150796.
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      50. Hardison W. Hepatic taurine concentration and dietary taurine as regulators of bile acid conjugation with taurine. Gastroenterology. 1978 Jul; 75(1):71-5. PMID: 401099.
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      51. Hardison W. Polyps of the colon: when and how should they be removed. Med Times. 1978 Jun; 106(6):44-51. PMID: 661534.
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      52. Hardison W, Wood CA, Proffitt JH. Quantification of taurine synthesis in the intact rat and cat liver. Proc Soc Exp Biol Med. 1977 May; 155(1):55-8. PMID: 859882.
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      53. Hardison W, Proffitt JH. Influence of hepatic taurine concentration on bile acid conjugation with taurine. Am J Physiol. 1977 Jan; 232(1):E75-9. PMID: 835705.
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      54. Brown H, Hardison W. Fluorocarbon liver perfusion and fluorocarbon-glycine interaction. Fed Proc. 1975 May; 34(6):1516-7. PMID: 1126450.
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      55. Hardison W, Apter JT. Use of hybrid computers to analyze behavior of detailed models of biological systems. II. System parameters used in bile salt stimulated biliary cholesterol excretion. Comput Biol Med. 1974 Jun; 4(1):3-17. PMID: 4846475.
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      56. Brown H, Hardison W. Fluorocarbon sonicated as a substitute for erythrocytes in rat liver perfusion. Surgery. 1972 Mar; 71(3):388-94. PMID: 5010222.
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      57. Hardison W. Bile salts and the liver. Prog Liver Dis. 1972; 4:83-95. PMID: 4569013.
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      58. Hardison W, Apter JT. Micellar theory of biliary cholesterol excretion. Am J Physiol. 1972 Jan; 222(1):61-7. PMID: 5060227.
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      59. Hardison W. Metabolism of sodium dehydrocholate by the rat liver: its effect on micelle formation in bile. J Lab Clin Med. 1971 May; 77(5):811-20. PMID: 5557664.
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      60. Hedger RW, Hardison W. Transient macroamylasemia during an exacerbation of acute intermittent porphyria. Gastroenterology. 1971 May; 60(5):903-8. PMID: 5581334.
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      61. Hardison W, Rosenberg IH. The effect of neomycin on bile salt metabolism and fat digestion in man. J Lab Clin Med. 1969 Oct; 74(4):564-73. PMID: 5821514.
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      62. Hardison W, Norman JC. Effect of secretin on bile osmolality. J Lab Clin Med. 1969 Jan; 73(1):34-41. PMID: 5762162.
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      63. Brown H, Hardison W. Substitution of fluorocarbon for erythrocytes in rat liver perfusion. J Assoc Adv Med Instrum. 1969 Jan; 3(1 Pt 1):25-30. PMID: 5293909.
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      64. Hardison W, Norman JC. Electrolyte composition of the secretin fraction of bile from the perfused pig liver. Am J Physiol. 1968 Apr; 214(4):758-63. PMID: 5642937.
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      65. Hardison W, Rosenberg IH. Bile-salt deficiency in the steatorrhea following resection of the ileum and proximal colon. N Engl J Med. 1967 Aug 17; 277(7):337-42. PMID: 4378268.
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      66. Norman JC, Covelli VH, Hardison W, McDermott WV. Experimental studies related to clinical xenogeneic liver perfusions. Transplantation. 1967 Jul; 5(4):Suppl:809-19. PMID: 4860613.
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      67. Rosenberg IH, Hardison W, Bull DM. Abnormal bile-salt patterns and intestinal bacterial overgrowth associated with malabsorption. N Engl J Med. 1967 Jun 22; 276(25):1391-7. PMID: 6026403.
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      68. Hardison W, Norman JC. Ex vivo pig liver perfusion for acute hepatic failure: bile salt composition of pig bile during perfusion. Medicine (Baltimore). 1967 Mar; 46(2):97-102. PMID: 6027467.
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      69. Hardison W, Greene EA, Norman JC. The viability and effect of flow upon function of the ex vivo perfused pig liver. J Lab Clin Med. 1967 Feb; 69(2):245-55. PMID: 6016623.
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      70. Norman JC, Hardison W, Covelli V, McDermott WV. Metabolic responses during experimental hepatectomy as related to subsequent perfusion, preservation, or transplantation. Am J Surg. 1966 Sep; 112(3):407-11. PMID: 5331167.
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      71. Hardison W, Lee FI. Prognosis in acute liver disease of the alcoholic patient. N Engl J Med. 1966 Jul 14; 275(2):61-6. PMID: 5936867.
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