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    Randy Cowling

    TitleAssociate Project Scientist
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0663
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Development of Mouse Model to Study Fibroblast Functions
      NIH/NHLBI R21HL080358Jan 1, 2006 - Nov 30, 2008
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Cowling R, Park JI, Sotimehin AE, Greenberg BH. Ascorbate starvation alters endoplasmic reticulum-resident enzymes in cardiac fibroblasts, priming them for increased procollagen secretion. J Mol Cell Cardiol. 2017 Sep 18; 113:1-8. PMID: 28923350.
        View in: PubMed
      2. Cowling R. A sobering reminder that heavy drinking and heart failure do not mix. J Mol Cell Cardiol. 2016 Aug; 97:150-2. PMID: 27181054.
        View in: PubMed
      3. Blondelle J, Lange S, Greenberg BH, Cowling R. Cathepsins in heart disease-chewing on the heartache? Am J Physiol Heart Circ Physiol. 2015 May 01; 308(9):H974-6. PMID: 25747750; PMCID: PMC4578146.
      4. Cowling R. The aging heart, endothelin-1 and the senescent cardiac fibroblast. J Mol Cell Cardiol. 2015 Apr; 81:12-4. PMID: 25647277.
        View in: PubMed
      5. Cowling R, Yeo SJ, Kim IJ, Park JI, Gu Y, Dalton ND, Peterson KL, Greenberg BH. Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol. 2014 Sep 01; 307(5):H773-81. PMID: 24993042; PMCID: PMC4187391.
      6. Greenberg B, Cowling R. An ACE for my sweet heart. J Am Coll Cardiol. 2012 Feb 21; 59(8):748-50. PMID: 22340267.
        View in: PubMed
      7. Iwata M, Cowling R, Yeo SJ, Greenberg B. Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):542-7. PMID: 21147120; PMCID: PMC3085048.
      8. Kim MA, Yang D, Kida K, Molotkova N, Yeo SJ, Varki N, Iwata M, Dalton ND, Peterson KL, Siems WE, Walther T, Cowling R, Kjekshus J, Greenberg B. Effects of ACE2 inhibition in the post-myocardial infarction heart. J Card Fail. 2010 Sep; 16(9):777-85. PMID: 20797602; PMCID: PMC2929397.
      9. Zhang X, Greenberg BH, Cowling R. Improving the titer of recombinant adenovirus by suppressing problematic transgene transcription during packaging. Biotechniques. 2008 Jan; 44(1):85-9. PMID: 18254384.
        View in: PubMed
      10. Iwata M, Cowling R, Gurantz D, Moore C, Zhang S, Yuan JX, Greenberg BH. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2356-63. PMID: 16024575.
        View in: PubMed
      11. Cowling R, Zhang X, Reese VC, Iwata M, Gurantz D, Dillmann WH, Greenberg BH. Effects of cytokine treatment on angiotensin II type 1A receptor transcription and splicing in rat cardiac fibroblasts. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1176-83. PMID: 15879490.
        View in: PubMed
      12. Gurantz D, Cowling R, Varki N, Frikovsky E, Moore CD, Greenberg BH. IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart. J Mol Cell Cardiol. 2005 Mar; 38(3):505-15. PMID: 15733910.
        View in: PubMed
      13. Fantozzi I, Zhang S, Platoshyn O, Remillard CV, Cowling R, Yuan JX. Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1233-45. PMID: 12909593.
        View in: PubMed
      14. Peng J, Gurantz D, Tran V, Cowling R, Greenberg BH. Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis. Circ Res. 2002 Dec 13; 91(12):1119-26. PMID: 12480812.
        View in: PubMed
      15. Cowling R, Gurantz D, Peng J, Dillmann WH, Greenberg BH. Transcription factor NF-kappa B is necessary for up-regulation of type 1 angiotensin II receptor mRNA in rat cardiac fibroblasts treated with tumor necrosis factor-alpha or interleukin-1 beta. J Biol Chem. 2002 Feb 22; 277(8):5719-24. PMID: 11600498.
        View in: PubMed
      16. Cowling R, Birnboim HC. Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. J Leukoc Biol. 2000 Feb; 67(2):240-8. PMID: 10670586.
        View in: PubMed
      17. Haqqani AS, Cowling R, Maroun JA, Birnboim HC. Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. J Histochem Cytochem. 1999 Dec; 47(12):1563-74. PMID: 10567440.
        View in: PubMed
      18. Gurantz D, Cowling R, Villarreal FJ, Greenberg BH. Tumor necrosis factor-alpha upregulates angiotensin II type 1 receptors on cardiac fibroblasts. Circ Res. 1999 Aug 06; 85(3):272-9. PMID: 10436170.
        View in: PubMed
      19. Cowling R, Birnboim HC. Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT). Mol Membr Biol. 1998 Oct-Dec; 15(4):177-87. PMID: 10087504.
        View in: PubMed
      20. Cowling R, Birnboim HC. Incorporation of [32P]orthophosphate into inorganic polyphosphates by human granulocytes and other human cell types. J Biol Chem. 1994 Apr 01; 269(13):9480-5. PMID: 8144532.
        View in: PubMed