Randy Cowling

Title(s)Assistant Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel collagen-based inflammatory mediators of cardiomyopathy
    DoD/USAMRAA W81XWH2010091Jul 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Cardiac fibrosis is regulated by protein turnover in the endoplasmic reticulum
    NIH R01HL141361Apr 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Development of Mouse Model to Study Fibroblast Functions
    NIH R21HL080358Jan 1, 2006 - Nov 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A multi-stem cell basis for craniosynostosis and calvarial mineralization. Nature. 2023 Sep; 621(7980):804-812. Bok S, Yallowitz AR, Sun J, McCormick J, Cung M, Hu L, Lalani S, Li Z, Sosa BR, Baumgartner T, Byrne P, Zhang T, Morse KW, Mohamed FF, Ge C, Franceschi RT, Cowling RT, Greenberg BH, Pisapia DJ, Imahiyerobo TA, Lakhani S, Ross ME, Hoffman CE, Debnath S, Greenblatt MB. PMID: 37730988; PMCID: PMC10799660.
      View in: PubMed   Mentions: 6     Fields:    
    2. Control of craniofacial development by the collagen receptor, discoidin domain receptor 2. Elife. 2023 01 19; 12. Mohamed FF, Ge C, Hallett SA, Bancroft AC, Cowling RT, Ono N, Binrayes AA, Greenberg B, Levi B, Kaartinen VM, Franceschi RT. PMID: 36656123; PMCID: PMC9977278.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    3. The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development. Bone Res. 2022 Feb 09; 10(1):11. Mohamed FF, Ge C, Cowling RT, Lucas D, Hallett SA, Ono N, Binrayes AA, Greenberg B, Franceschi RT. PMID: 35140200; PMCID: PMC8828874.
      View in: PubMed   Mentions: 8  
    4. Discoidin Domain Receptor 2 Regulates AT1R Expression in Angiotensin II-Stimulated Cardiac Fibroblasts via Fibronectin-Dependent Integrin-β1 Signaling. Int J Mol Sci. 2021 Aug 28; 22(17). Titus AS, Venugopal H, Ushakumary MG, Wang M, Cowling RT, Lakatta EG, Kailasam S. PMID: 34502259; PMCID: PMC8431251.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. 5-Methoxytryptophan: A game changer in the management of post-myocardial infarction? J Mol Cell Cardiol. 2021 11; 160:71-72. Cho JY, Cowling RT. PMID: 34265275.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Collagen receptor cross-talk determines α-smooth muscle actin-dependent collagen gene expression in angiotensin II-stimulated cardiac fibroblasts. J Biol Chem. 2019 12 20; 294(51):19723-19739. V H, Titus AS, Cowling RT, Kailasam S. PMID: 31699892; PMCID: PMC6926455.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    7. Cathepsin A Inhibitors to Treat Heart Disease: Much Potential, Many Questions. JACC Basic Transl Sci. 2019 Jun; 4(3):345-347. Cowling RT. PMID: 31312758; PMCID: PMC6610153.
      View in: PubMed   Mentions: 1  
    8. Mechanisms of cardiac collagen deposition in experimental models and human disease. Transl Res. 2019 07; 209:138-155. Cowling RT, Kupsky D, Kahn AM, Daniels LB, Greenberg BH. PMID: 30986384; PMCID: PMC6996650.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    9. Ascorbate starvation alters endoplasmic reticulum-resident enzymes in cardiac fibroblasts, priming them for increased procollagen secretion. J Mol Cell Cardiol. 2017 12; 113:1-8. Cowling RT, Park JI, Sotimehin AE, Greenberg BH. PMID: 28923350.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. A sobering reminder that heavy drinking and heart failure do not mix. J Mol Cell Cardiol. 2016 08; 97:150-2. Cowling RT. PMID: 27181054.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Cathepsins in heart disease-chewing on the heartache? Am J Physiol Heart Circ Physiol. 2015 May 01; 308(9):H974-6. Blondelle J, Lange S, Greenberg BH, Cowling RT. PMID: 25747750; PMCID: PMC4578146.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. The aging heart, endothelin-1 and the senescent cardiac fibroblast. J Mol Cell Cardiol. 2015 Apr; 81:12-4. Cowling RT. PMID: 25647277.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    13. Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol. 2014 Sep 01; 307(5):H773-81. Cowling RT, Yeo SJ, Kim IJ, Park JI, Gu Y, Dalton ND, Peterson KL, Greenberg BH. PMID: 24993042; PMCID: PMC4187391.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    14. An ACE for my sweet heart. J Am Coll Cardiol. 2012 Feb 21; 59(8):748-50. Greenberg B, Cowling RT. PMID: 22340267.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    15. Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):542-7. Iwata M, Cowling RT, Yeo SJ, Greenberg B. PMID: 21147120; PMCID: PMC3085048.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    16. Effects of ACE2 inhibition in the post-myocardial infarction heart. J Card Fail. 2010 Sep; 16(9):777-85. Kim MA, Yang D, Kida K, Molotkova N, Yeo SJ, Varki N, Iwata M, Dalton ND, Peterson KL, Siems WE, Walther T, Cowling RT, Kjekshus J, Greenberg B. PMID: 20797602; PMCID: PMC2929397.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    17. Improving the titer of recombinant adenovirus by suppressing problematic transgene transcription during packaging. Biotechniques. 2008 Jan; 44(1):85-9. Zhang X, Greenberg BH, Cowling RT. PMID: 18254384.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6):H2356-63. Iwata M, Cowling RT, Gurantz D, Moore C, Zhang S, Yuan JX, Greenberg BH. PMID: 16024575.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    19. Effects of cytokine treatment on angiotensin II type 1A receptor transcription and splicing in rat cardiac fibroblasts. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1176-83. Cowling RT, Zhang X, Reese VC, Iwata M, Gurantz D, Dillmann WH, Greenberg BH. PMID: 15879490.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    20. IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart. J Mol Cell Cardiol. 2005 Mar; 38(3):505-15. Gurantz D, Cowling RT, Varki N, Frikovsky E, Moore CD, Greenberg BH. PMID: 15733910.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    21. Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1233-45. Fantozzi I, Zhang S, Platoshyn O, Remillard CV, Cowling RT, Yuan JX. PMID: 12909593.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    22. Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis. Circ Res. 2002 Dec 13; 91(12):1119-26. Peng J, Gurantz D, Tran V, Cowling RT, Greenberg BH. PMID: 12480812.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    23. Transcription factor NF-kappa B is necessary for up-regulation of type 1 angiotensin II receptor mRNA in rat cardiac fibroblasts treated with tumor necrosis factor-alpha or interleukin-1 beta. J Biol Chem. 2002 Feb 22; 277(8):5719-24. Cowling RT, Gurantz D, Peng J, Dillmann WH, Greenberg BH. PMID: 11600498.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    24. Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. J Leukoc Biol. 2000 Feb; 67(2):240-8. Cowling RT, Birnboim HC. PMID: 10670586.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. J Histochem Cytochem. 1999 Dec; 47(12):1563-74. Haqqani AS, Cowling RT, Maroun JA, Birnboim HC. PMID: 10567440.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Tumor necrosis factor-alpha upregulates angiotensin II type 1 receptors on cardiac fibroblasts. Circ Res. 1999 Aug 06; 85(3):272-9. Gurantz D, Cowling RT, Villarreal FJ, Greenberg BH. PMID: 10436170.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    27. Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT). Mol Membr Biol. 1998 Oct-Dec; 15(4):177-87. Cowling RT, Birnboim HC. PMID: 10087504.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Incorporation of [32P]orthophosphate into inorganic polyphosphates by human granulocytes and other human cell types. J Biol Chem. 1994 Apr 01; 269(13):9480-5. Cowling RT, Birnboim HC. PMID: 8144532.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
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