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    Philbert Tsai

    Address9500 Gilman Drive #0374
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Báez-Yánez MG, Ehses P, Mirkes C, Tsai P, Kleinfeld D, Scheffler K. The impact of vessel size, orientation and intravascular contribution on the neurovascular fingerprint of BOLD bSSFP fMRI. Neuroimage. 2017 Sep 08; 163:13-23. PMID: 28890417.
        View in: PubMed
      2. Schmid F, Tsai P, Kleinfeld D, Jenny P, Weber B. Depth-dependent flow and pressure characteristics in cortical microvascular networks. PLoS Comput Biol. 2017 Feb; 13(2):e1005392. PMID: 28196095.
        View in: PubMed
      3. Gould IG, Tsai P, Kleinfeld D, Linninger A. The capillary bed offers the largest hemodynamic resistance to the cortical blood supply. J Cereb Blood Flow Metab. 2017 Jan; 37(1):52-68. PMID: 27780904.
        View in: PubMed
      4. Tsai P, Mateo C, Field JJ, Schaffer CB, Anderson ME, Kleinfeld D. Ultra-large field-of-view two-photon microscopy. Opt Express. 2015 Jun 01; 23(11):13833-47. PMID: 26072755; PMCID: PMC4523368.
      5. Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Mateo C, Mellander L, Nishimura N, Schaffer CB, Tsai P, Kleinfeld D. Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation. 2015 Apr; 22(3):204-218. PMID: 25705966; PMCID: PMC4393797.
      6. Jeong DC, Tsai P, Kleinfeld D. All-optical osteotomy to create windows for transcranial imaging in mice. Opt Express. 2013 Oct 07; 21(20):23160-8. PMID: 24104230; PMCID: PMC3971057.
      7. Blinder P, Tsai P, Kaufhold JP, Knutsen PM, Suhl H, Kleinfeld D. The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow. Nat Neurosci. 2013 Jul; 16(7):889-97. PMID: 23749145; PMCID: PMC4141079.
      8. Tsai P, Blinder P, Squier JA, Kleinfeld D. All-optical in situ histology of brain tissue with femtosecond laser pulses. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):327-34. PMID: 23547156.
        View in: PubMed
      9. Shih AY, Blinder P, Tsai P, Friedman B, Stanley G, Lyden PD, Kleinfeld D. The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nat Neurosci. 2013 Jan; 16(1):55-63. PMID: 23242312; PMCID: PMC3952571.
      10. Kaufhold JP, Tsai P, Blinder P, Kleinfeld D. Vectorization of optically sectioned brain microvasculature: learning aids completion of vascular graphs by connecting gaps and deleting open-ended segments. Med Image Anal. 2012 Aug; 16(6):1241-58. PMID: 22854035; PMCID: PMC3443315.
      11. Shih AY, Mateo C, Drew PJ, Tsai P, Kleinfeld D. A polished and reinforced thinned-skull window for long-term imaging of the mouse brain. J Vis Exp. 2012 Mar 07; (61). PMID: 22433225; PMCID: PMC3460568.
      12. Jeong DC, Tsai P, Kleinfeld D. Prospect for feedback guided surgery with ultra-short pulsed laser light. Curr Opin Neurobiol. 2012 Feb; 22(1):24-33. PMID: 22088392; PMCID: PMC3763077.
      13. Kleinfeld D, Bharioke A, Blinder P, Bock DD, Briggman KL, Chklovskii DB, Denk W, Helmstaedter M, Kaufhold JP, Lee WC, Meyer HS, Micheva KD, Oberlaender M, Prohaska S, Reid RC, Smith SJ, Takemura S, Tsai P, Sakmann B. Large-scale automated histology in the pursuit of connectomes. J Neurosci. 2011 Nov 09; 31(45):16125-38. PMID: 22072665; PMCID: PMC3758571.
      14. Kleinfeld D, Blinder P, Drew PJ, Driscoll JD, Muller A, Tsai P, Shih AY. A guide to delineate the logic of neurovascular signaling in the brain. Front Neuroenergetics. 2011; 3:1. PMID: 21559095; PMCID: PMC3085135.
      15. Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai P, Kleinfeld D. Chronic optical access through a polished and reinforced thinned skull. Nat Methods. 2010 Dec; 7(12):981-4. PMID: 20966916; PMCID: PMC3204312.
      16. Vitek DN, Adams DE, Johnson A, Tsai P, Backus S, Durfee CG, Kleinfeld D, Squier JA. Temporally focused femtosecond laser pulses for low numerical aperture micromachining through optically transparent materials. Opt Express. 2010 Aug 16; 18(17):18086-94. PMID: 20721196; PMCID: PMC3408926.
      17. Tsai P, Kaufhold JP, Blinder P, Friedman B, Drew PJ, Karten HJ, Lyden PD, Kleinfeld D. Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci. 2009 Nov 18; 29(46):14553-70. PMID: 19923289; PMCID: PMC4972024.
      18. Chen B, Friedman B, Cheng Q, Tsai P, Schim E, Kleinfeld D, Lyden PD. Severe blood-brain barrier disruption and surrounding tissue injury. Stroke. 2009 Dec; 40(12):e666-74. PMID: 19893002; PMCID: PMC2819286.
      19. Friedman B, Schachtrup C, Tsai P, Shih AY, Akassoglou K, Kleinfeld D, Lyden PD. Acute vascular disruption and aquaporin 4 loss after stroke. Stroke. 2009 Jun; 40(6):2182-90. PMID: 19372455; PMCID: PMC2753985.
      20. Tsai P, Blinder P, Migliori BJ, Neev J, Jin Y, Squier JA, Kleinfeld D. Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems. Curr Opin Biotechnol. 2009 Feb; 20(1):90-9. PMID: 19269159; PMCID: PMC3123732.
      21. Shih AY, Friedman B, Drew PJ, Tsai P, Lyden PD, Kleinfeld D. Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke. J Cereb Blood Flow Metab. 2009 Apr; 29(4):738-51. PMID: 19174826; PMCID: PMC2893883.
      22. Nguyen QT, Tsai P, Kleinfeld D. MPScope: a versatile software suite for multiphoton microscopy. J Neurosci Methods. 2006 Sep 30; 156(1-2):351-9. PMID: 16621010.
        View in: PubMed
      23. Nishimura N, Schaffer CB, Friedman B, Tsai P, Lyden PD, Kleinfeld D. Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat Methods. 2006 Feb; 3(2):99-108. PMID: 16432519.
        View in: PubMed
      24. Schaffer CB, Friedman B, Nishimura N, Schroeder LF, Tsai P, Ebner FF, Lyden PD, Kleinfeld D. Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS Biol. 2006 Feb; 4(2):e22. PMID: 16379497; PMCID: PMC1324794.
      25. Tsai P, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. All-optical histology using ultrashort laser pulses. Neuron. 2003 Jul 03; 39(1):27-41. PMID: 12848930.
        View in: PubMed