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Treatment of spinal injury muscle spasticity by spinal subpial AAV9-GAD65/VGAT delivery: an efficacy and safety study in rat, pig and NHP. Mol Ther. 2026 Jun 04.
Nguyen D, Yoshizumi T, Sawamura M, Agashkov K, Krotov V, Hruska-Plochan M, Tadokoro T, Kemthong T, Platoshyn O, Miyanohara A, Kamizato K, Juhas S, Juhasova J, Studenovska H, Polymenidou M, Skalnikova HK, Motlik J, Proks V, Teeravechyan S, Abraham ME, Vanicky I, Belan P, Ciacci J, Marsala M. PMID: 42244183.
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PubMed Mentions: Fields:
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Evaluation of a commercial AI-assisted cell counting software for dopaminergic neurons across species. PLoS One. 2026; 21(3):e0344621.
Kunugitani K, Sawamura M, Taguchi T, Hirato T, Uemura N, Ayaki T, Nakanishi E, Yamakado H, Ishimoto T, Onoe H, Isa T, Matsumoto R, Takahashi R. PMID: 41843600; PMCID: PMC12994822.
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HumansAnimalsCells
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Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson's disease. Cell Stem Cell. 2025 Sep 04; 32(9):1346-1355.e3.
Morizane A, Yamasaki E, Shindo T, Anazawa T, Sawamoto N, Shima A, Yamakado H, Nakanishi E, Sawamura M, Taruno Y, Doi D, Kikuchi T, Kawasaki Y, Saito MK, Kikuchi T, Arakawa Y, Miyamoto S, Nakamoto Y, Takahashi R, Takahashi J. PMID: 40834856.
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PubMed Mentions:
3 Fields:
Translation:
HumansCellsCTClinical Trials
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Cortical hyperexcitability in corticobasal syndrome as revealed by giant somatosensory evoked potentials. Clin Neurophysiol. 2025 Oct; 178:2110977.
Tojima M, Sawamura M, Shima A, Nakanishi E, Sawamoto N, Takahashi R, Ikeda A, Matsumoto R. PMID: 40834562.
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Humans
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Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson's disease. NPJ Parkinsons Dis. 2025 Jul 31; 11(1):224.
Ohira J, Sawamura M, Kawano K, Sato R, Taguchi T, Ishimoto T, Ueda J, Ikuno M, Matsuzawa SI, Matsuzaki K, Takahashi R, Yamakado H. PMID: 40744939; PMCID: PMC12313852.
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3
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Expectations regarding regenerative medicine and attitudes toward invasive surgical therapies in patients with Parkinson's disease: A cross-sectional survey. Clin Park Relat Disord. 2025; 12:100341.
Watabe M, Shima A, Takeda K, Terada Y, Sakato Y, Nishida A, Wada I, Sakamaki-Tsukita H, Yoshimura K, Kambe D, Furukawa K, Sawamura M, Nakanishi E, Taruno Y, Yamakado H, Takahashi R, Sawamoto N. PMID: 40475391; PMCID: PMC12139427.
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Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson's disease. Nature. 2025 05; 641(8064):971-977.
Sawamoto N, Doi D, Nakanishi E, Sawamura M, Kikuchi T, Yamakado H, Taruno Y, Shima A, Fushimi Y, Okada T, Kikuchi T, Morizane A, Hiramatsu S, Anazawa T, Shindo T, Ueno K, Morita S, Arakawa Y, Nakamoto Y, Miyamoto S, Takahashi R, Takahashi J. PMID: 40240591; PMCID: PMC12095070.
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47 Fields:
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HumansCellsCTClinical Trials
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Neural substrates underlying distinct dual cognitive syndromes in Parkinson's disease. Eur J Neurol. 2025 01; 32(1):e70022.
Yoshimura K, Shima A, Kambe D, Furukawa K, Nishida A, Wada I, Sakato Y, Sakamaki-Tsukita H, Terada Y, Yamakado H, Taruno Y, Nakanishi E, Sawamura M, Fujimoto K, Fushimi Y, Okada T, Nakamoto Y, Hanakawa T, Takahashi R, Sawamoto N. PMID: 39716907; PMCID: PMC11666957.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Technique for Intranasal Administration of α-Synuclein Aggregates. J Vis Exp. 2024 11 08; (213).
Sawamura M, Takahashi R. PMID: 39584666.
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Animals
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A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy. Mol Ther Nucleic Acids. 2024 Dec 10; 35(4):102380.
Sawamura M, Tachikawa K, Hikawa R, Akiyama H, Kaji S, Yasuda K, Leu AI, Hong H, Mukthavaram R, Chivukula P, Yamakado H, Hirabayashi Y, Takahashi R, Matsuzawa SI. PMID: 39640012; PMCID: PMC11617236.
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Delineating three distinct spatiotemporal patterns of brain atrophy in Parkinson's disease. Brain. 2024 Nov 04; 147(11):3702-3713.
Sakato Y, Shima A, Terada Y, Takeda K, Sakamaki-Tsukita H, Nishida A, Yoshimura K, Wada I, Furukawa K, Kambe D, Togo H, Mukai Y, Sawamura M, Nakanishi E, Yamakado H, Fushimi Y, Okada T, Takahashi Y, Nakamoto Y, Takahashi R, Hanakawa T, Sawamoto N. PMID: 39445741.
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13 Fields:
Translation:
Humans
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Involvement of the basal forebrain and hippocampus in memory deficits in Parkinson's disease. Parkinsonism Relat Disord. 2024 Nov; 128:107134.
Sakamaki-Tsukita H, Shima A, Kambe D, Furukawa K, Nishida A, Wada I, Yoshimura K, Sakato Y, Terada Y, Yamakado H, Taruno Y, Nakanishi E, Sawamura M, Fushimi Y, Okada T, Nakamoto Y, Zaborszky L, Takahashi R, Sawamoto N. PMID: 39293154; PMCID: PMC12012929.
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Humans
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Distinct Clinical Implications of Patient- Versus Clinician-Rated Motor Symptoms in Parkinson's Disease. Mov Disord. 2024 Oct; 39(10):1799-1808.
Kikuya A, Tsukita K, Sawamura M, Yoshimura K, Takahashi R. PMID: 39092513.
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2 Fields:
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Humans
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Frontoparietal-Striatal Network and Nucleus Basalis Modulation in Patients With Parkinson Disease and Gait Disturbance. Neurology. 2024 Aug 13; 103(3):e209606.
Nishida A, Shima A, Kambe D, Furukawa K, Sakamaki-Tsukita H, Yoshimura K, Wada I, Sakato Y, Terada Y, Sawamura M, Nakanishi E, Taruno Y, Yamakado H, Fushimi Y, Okada T, Nakamoto Y, Takahashi R, Sawamoto N. PMID: 38976821.
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7 Fields:
Translation:
Humans
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Resident Memory-like CD8+ T Cells Are Involved in Chronic Inflammatory and Neurodegenerative Diseases in the CNS. Neurol Neuroimmunol Neuroinflamm. 2024 01; 11(1).
Kimura K, Nishigori R, Hamatani M, Sawamura M, Ashida S, Fujii C, Takata M, Lin Y, Sato W, Okamoto T, Kuzuya A, Takahashi R, Yamamura T, Kondo T. PMID: 37949669; PMCID: PMC10691221.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs. Parkinsonism Relat Disord. 2023 07; 112:105440.
Sawamura M, Ohira J, Hikawa R, Ishimoto T, Nakanishi E, Yamakado H, Takahashi R. PMID: 37267818.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission. Mov Disord. 2023 06; 38(6):1056-1067.
Ueda J, Uemura N, Ishimoto T, Taguchi T, Sawamura M, Nakanishi E, Ikuno M, Matsuzawa S, Yamakado H, Takahashi R. PMID: 37066491.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Idiopathic Intracranial Hypertension with Disproportionately Enlarged Subarachnoid Space Hydrocephalus on Imaging. Intern Med. 2023 Oct 15; 62(20):3043-3046.
Kunugitani K, Miura S, Sawamura M, Mitani K, Okawa M, Egawa N, Takahashi R. PMID: 36889711; PMCID: PMC10641207.
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Humans
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Lomerizine Improved Bath-related Headache Presenting as Reversible Cerebral Vasoconstriction Syndrome. Intern Med. 2023 08 15; 62(16):2445.
Sawamura M, Ogawa M. PMID: 36631090; PMCID: PMC10484761.
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Humans
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Dropped head syndrome due to chemoradiotherapy for nasal lymphoma, characterised by short tau inversion recovery high signal intensity in the cervical paraspinal muscles. BMJ Case Rep. 2022 11 11; 15(11).
Inoue R, Sawamura M, Yoshimura M, Takahashi R. PMID: 36368727; PMCID: PMC9660595.
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Humans
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Ultrasonography Aids in the Diagnosis of Neurolymphomatosis. Intern Med. 2023 06 15; 62(12):1869-1871.
Taniguchi T, Sawamura M, Fujii H, Takahashi R. PMID: 36351579; PMCID: PMC10332962.
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Humans
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Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb. Mov Disord. 2022 10; 37(10):2033-2044.
Sawamura M, Onoe H, Tsukada H, Isa K, Yamakado H, Okuda S, Ikuno M, Hatanaka Y, Murayama S, Uemura N, Isa T, Takahashi R. PMID: 35989519.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation. Sci Rep. 2022 07 25; 12(1):12636.
Sawamura M, Imamura K, Hikawa R, Enami T, Nagahashi A, Yamakado H, Ichijo H, Fujisawa T, Yamashita H, Minamiyama S, Kaido M, Wada H, Urushitani M, Inoue H, Egawa N, Takahashi R. PMID: 35879519; PMCID: PMC9314329.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Motor Progression and Nigrostriatal Neurodegeneration in Parkinson Disease. Ann Neurol. 2022 07; 92(1):110-121.
Furukawa K, Shima A, Kambe D, Nishida A, Wada I, Sakamaki H, Yoshimura K, Terada Y, Sakato Y, Mitsuhashi M, Sawamura M, Nakanishi E, Taruno Y, Yamakado H, Fushimi Y, Okada T, Nakamoto Y, Takahashi R, Sawamoto N. PMID: 35428994.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Rapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Mice. Neurotherapeutics. 2022 01; 19(1):289-304.
Okuda S, Uemura N, Sawamura M, Taguchi T, Ikuno M, Uemura MT, Yamakado H, Takahashi R. PMID: 34935120; PMCID: PMC9130450.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models. Mov Disord. 2021 07; 36(7):1554-1564.
Ueda J, Uemura N, Sawamura M, Taguchi T, Ikuno M, Kaji S, Taruno Y, Matsuzawa S, Yamakado H, Takahashi R. PMID: 33813737.
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PubMed Mentions:
16 Fields:
Translation:
Animals
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α-Synuclein Propagation Mouse Models of Parkinson's Disease. Methods Mol Biol. 2021; 2322:119-130.
Uemura N, Ueda J, Okuda S, Sawamura M, Takahashi R. PMID: 34043198.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy. Acta Neuropathol Commun. 2020 07 29; 8(1):120.
Kaji S, Maki T, Ueda J, Ishimoto T, Inoue Y, Yasuda K, Sawamura M, Hikawa R, Ayaki T, Yamakado H, Takahashi R. PMID: 32727582; PMCID: PMC7391509.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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The Usefulness of Thin-section Iso-Voxel Diffusion Weighted Imaging for Stroke Subtype Classification: Case Series and Review. J Stroke Cerebrovasc Dis. 2020 May; 29(5):104755.
Sawamura M, Okawa T, Kaji S, Yoshida H, Kim K, Harada K. PMID: 32171626.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model. Brain. 2020 01 01; 143(1):249-265.
Taguchi T, Ikuno M, Hondo M, Parajuli LK, Taguchi K, Ueda J, Sawamura M, Okuda S, Nakanishi E, Hara J, Uemura N, Hatanaka Y, Ayaki T, Matsuzawa S, Tanaka M, El-Agnaf OMA, Koike M, Yanagisawa M, Uemura MT, Yamakado H, Takahashi R. PMID: 31816026.
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PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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Unilateral Hypoglossal Nerve Palsy: A Hidden Tumor. Intern Med. 2020 02 15; 59(4):587-588.
Sawamura M, Kaji S, Takahashi R. PMID: 31666470; PMCID: PMC7056366.
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[Neurologic Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review]. Brain Nerve. 2018 Jan; 70(1):41-54.
Komaroff AL, Takahashi R, Yamamura T, Sawamura M. PMID: 29348374.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Innate immunity regulates α-synuclein clearance. Mov Disord. 2016 05; 31(5):638.
Sawamura M, Uemura N, Takahashi R. PMID: 26946483.
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Humans
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[Pathophysiological similarity between restless genital syndrome and restless legs syndrome in Parkinson's disease]. Rinsho Shinkeigaku. 2015; 55(11):850.
Sawamura M, Toma K, Udaka F. PMID: 26447097.
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Humans
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[Neuro-neutrophilic disease suspected by human leukocyte antigen (HLA) typing and brain biopsy: a case report]. Rinsho Shinkeigaku. 2015; 55(1):13-7.
Nakanishi E, Sawamura M, Maruhama S, Yamada H, Kim G, Harada K. PMID: 25672859.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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[A case of Parkinson's disease following restless genial sensation]. Rinsho Shinkeigaku. 2015; 55(4):266-8.
Sawamura M, Toma K, Unai Y, Sekiya T, Nishinaka K, Udaka F. PMID: 25904258.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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[Case of ataxic sensory neuronopathy associated with Sjögren's syndrome]. Rinsho Shinkeigaku. 2014; 54(5):413-6.
Sawamura M, Oishi W, Nakanishi E, Maruhama S, Kim G, Harada K. PMID: 24943078.
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Humans
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[Tick-bite in penile skin : a case report]. Hinyokika Kiyo. 2010 Mar; 56(3):185-7.
Nishi M, Matsumoto K, Sawamura M, Nakamura K, Hayashi T, Satoh T, Iwamura M, Baba S. PMID: 20372050.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals