Robert Fahey

Title(s)Emeritus Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Whole cell and essential enzyme screening assays for mycothiol biosynthesis
    NIH R01AI072133Apr 1, 2007 - Mar 31, 2011
    Role: Principal Investigator
    MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    NIH R01AI049174Aug 1, 2000 - May 31, 2008
    Role: Principal Investigator
    MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    NIH R21AI049174Aug 1, 2000 - May 31, 2004
    Role: Principal Investigator
    MOLECULAR GENETICS OF MYCOTHIOL BIOSYNTHESIS
    NIH R03TW000976Sep 1, 1998 - Aug 31, 2002
    Role: Principal Investigator
    MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETS
    NIH R01AA011393Jul 1, 1996 - Jun 30, 2000
    Role: Principal Investigator
    ACTINOTHIONE IN THE DIAGNOSIS OF MYCOBACTERIAL INFECTION
    NIH R01AI036971Sep 30, 1994 - Jul 31, 1998
    Role: Principal Investigator
    MECHANISM OF RADIOPROTECTION BY AMINOTHIOLS
    NIH R01CA039582Apr 1, 1985 - Jun 30, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Leaf out times of temperate woody plants are related to phylogeny, deciduousness, growth habit and wood anatomy. New Phytol. 2014 Sep; 203(4):1208-1219. Panchen ZA, Primack RB, Nordt B, Ellwood ER, Stevens AD, Renner SS, Willis CG, Fahey R, Whittemore A, Du Y, Davis CC. PMID: 24942252.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    2. Glutathione analogs in prokaryotes. Biochim Biophys Acta. 2013 May; 1830(5):3182-98. Fahey RC. PMID: 23075826.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    3. Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis. FEBS Lett. 2012 Apr 05; 586(7):1004-8. Upton H, Newton GL, Gushiken M, Lo K, Holden D, Fahey RC, Rawat M. PMID: 22569254; PMCID: PMC3668096.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    4. Detoxification of toxins by bacillithiol in Staphylococcus aureus. Microbiology (Reading). 2012 Apr; 158(Pt 4):1117-1126. Newton GL, Fahey RC, Rawat M. PMID: 22262099; PMCID: PMC3949421.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    5. The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases. Biochemistry. 2011 Dec 13; 50(49):10751-60. Newton GL, Leung SS, Wakabayashi JI, Rawat M, Fahey RC. PMID: 22059487; PMCID: PMC3232311.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    6. The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4956-9. Hatzios SK, Schelle MW, Newton GL, Sogi KM, Holsclaw CM, Fahey RC, Bertozzi CR. PMID: 21795043; PMCID: PMC3184767.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    7. Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis. Bioorg Med Chem. 2011 Jul 01; 19(13):3956-64. Newton GL, Buchmeier N, La Clair JJ, Fahey RC. PMID: 21665483; PMCID: PMC3123436.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    8. Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants. J Bacteriol. 2011 Apr; 193(8):1981-90. Ta P, Buchmeier N, Newton GL, Rawat M, Fahey RC. PMID: 21335456; PMCID: PMC3133051.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    9. Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6482-6. Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD. PMID: 20308541; PMCID: PMC2851989.
      View in: PubMed   Mentions: 118     Fields:    Translation:Cells
    10. Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol. 2009 Sep; 5(9):625-7. Newton GL, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey RC. PMID: 19578333; PMCID: PMC3510479.
      View in: PubMed   Mentions: 132     Fields:    Translation:Cells
    11. Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. Microbiol Mol Biol Rev. 2008 Sep; 72(3):471-94. Newton GL, Buchmeier N, Fahey RC. PMID: 18772286; PMCID: PMC2546866.
      View in: PubMed   Mentions: 147     Fields:    Translation:Cells
    12. Unusual production of glutathione in Actinobacteria. Arch Microbiol. 2009 Jan; 191(1):89-93. Johnson T, Newton GL, Fahey RC, Rawat M. PMID: 18719892; PMCID: PMC2605195.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    13. An N-acyl homolog of mycothiol is produced in marine actinomycetes. Arch Microbiol. 2008 Nov; 190(5):547-57. Newton GL, Jensen PR, Macmillan JB, Fenical W, Fahey RC. PMID: 18629474; PMCID: PMC2574923.
      View in: PubMed   Mentions: 7     Fields:    Translation:CellsPHPublic Health
    14. Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA. Mol Microbiol. 2008 May; 68(4):805-9. Newton GL, Fahey RC. PMID: 18430078.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    15. Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production. J Bacteriol. 2007 Oct; 189(19):6796-805. Bzymek KP, Newton GL, Ta P, Fahey RC. PMID: 17644601; PMCID: PMC2045207.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    16. Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology. Biochemistry. 2007 Mar 20; 46(11):3234-45. Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A. PMID: 17323930; PMCID: PMC2613803.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    17. The mshA gene encoding the glycosyltransferase of mycothiol biosynthesis is essential in Mycobacterium tuberculosis Erdman. FEMS Microbiol Lett. 2006 Nov; 264(1):74-9. Buchmeier N, Fahey RC. PMID: 17020551.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    18. A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thiol-disulfide content and limited tolerance to stress. J Bacteriol. 2006 Sep; 188(17):6245-52. Buchmeier NA, Newton GL, Fahey RC. PMID: 16923891; PMCID: PMC1595396.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    19. Biochemistry of the initial steps of mycothiol biosynthesis. J Biol Chem. 2006 Nov 10; 281(45):33910-20. Newton GL, Ta P, Bzymek KP, Fahey RC. PMID: 16940050.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    20. Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S-transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis. Protein Expr Purif. 2006 Nov; 50(1):128-36. Gutierrez-Lugo MT, Newton GL, Fahey RC, Bewley CA. PMID: 16908186.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    21. A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening. Anal Biochem. 2006 Jun 15; 353(2):167-73. Newton GL, Ta P, Sareen D, Fahey RC. PMID: 16674910.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    22. Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. Protein Expr Purif. 2006 Jun; 47(2):542-50. Newton GL, Ko M, Ta P, Av-Gay Y, Fahey RC. PMID: 16630724.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    23. A mycothiol synthase mutant of Mycobacterium smegmatis produces novel thiols and has an altered thiol redox status. J Bacteriol. 2005 Nov; 187(21):7309-16. Newton GL, Ta P, Fahey RC. PMID: 16237013; PMCID: PMC1272995.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    24. Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation. J Androl. 2005 Sep-Oct; 26(5):629-37; discussion 638-40. Seligman J, Newton GL, Fahey RC, Shalgi R, Kosower NS. PMID: 16088041.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    25. Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein. J Bacteriol. 2004 Sep; 186(18):6050-8. Rawat M, Uppal M, Newton G, Steffek M, Fahey RC, Av-Gay Y. PMID: 15342574; PMCID: PMC515152.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    26. Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman. J Bacteriol. 2003 Nov; 185(22):6736-40. Sareen D, Newton GL, Fahey RC, Buchmeier NA. PMID: 14594852; PMCID: PMC262099.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    27. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry. 2003 Oct 21; 42(41):12067-76. Steffek M, Newton GL, Av-Gay Y, Fahey RC. PMID: 14556638.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    28. The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J Biol Chem. 2003 Nov 21; 278(47):47166-70. Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN. PMID: 12958317.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    29. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). J Bacteriol. 2003 Jun; 185(11):3476-9. Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y. PMID: 12754249; PMCID: PMC155378.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    30. Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics. Mol Microbiol. 2003 Mar; 47(6):1723-32. Buchmeier NA, Newton GL, Koledin T, Fahey RC. PMID: 12622824.
      View in: PubMed   Mentions: 71     Fields:    Translation:Cells
    31. Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors. Bioorg Med Chem. 2003 Feb 20; 11(4):601-8. Nicholas GM, Eckman LL, Newton GL, Fahey RC, Ray S, Bewley CA. PMID: 12538025.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    32. ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry. 2002 Jun 04; 41(22):6885-90. Sareen D, Steffek M, Newton GL, Fahey RC. PMID: 12033919.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    33. Blood thiols following amifostine and mesna infusions, a pediatric oncology group study. Drug Metab Dispos. 2001 Nov; 29(11):1460-6. Souid AK, Fahey RC, Aktas MK, Sayin OA, Karjoo S, Newton GL, Sadowitz PD, Dubowy RL, Bernstein ML. PMID: 11602522.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    34. Novel thiols of prokaryotes. Annu Rev Microbiol. 2001; 55:333-56. Fahey RC. PMID: 11544359.
      View in: PubMed   Mentions: 78     Fields:    Translation:Cells
    35. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J Bacteriol. 2000 Dec; 182(24):6958-63. Newton GL, Av-Gay Y, Fahey RC. PMID: 11092856; PMCID: PMC94821.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    36. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry. 2000 Sep 05; 39(35):10739-46. Newton GL, Av-Gay Y, Fahey RC. PMID: 10978158.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    37. Improved methods for immunoassay of mycothiol. J Clin Microbiol. 1999 Jul; 37(7):2153-7. Unson MD, Newton GL, Arnold KF, Davis CE, Fahey RC. PMID: 10364578; PMCID: PMC85106.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    38. Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity of chromatin is influenced by tightly bound spermine. Radiat Res. 1999 Mar; 151(3):354-62. Warters RL, Newton GL, Olive PL, Fahey RC. PMID: 10073674.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    39. Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis. Biochem Biophys Res Commun. 1999 Feb 16; 255(2):239-44. Newton GL, Unson MD, Anderberg SJ, Aguilera JA, Oh NN, delCardayre SB, Av-Gay Y, Fahey RC. PMID: 10049692.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    40. WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study. Cancer Chemother Pharmacol. 1999; 44(6):498-504. Souid AK, Fahey RC, Dubowy RL, Newton GL, Bernstein ML. PMID: 10550571.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    41. Mycothiol biosynthesis and metabolism. Cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol in mycobacterium smegmatis. J Biol Chem. 1998 Nov 13; 273(46):30391-7. Anderberg SJ, Newton GL, Fahey RC. PMID: 9804803.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    42. The limits to radioprotection of Chinese hamster V79 cells by WR-1065 under aerobic conditions. Radiat Res. 1998 Jun; 149(6):550-9. Calabro-Jones PM, Aguilera JA, Ward JF, Fahey RC. PMID: 9611093.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    43. An immunoassay for the detection and quantitative determination of mycothiol. J Immunol Methods. 1998 May 01; 214(1-2):29-39. Unson MD, Newton GL, Davis C, Fahey RC. PMID: 9692856.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    44. Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme. J Biol Chem. 1998 Mar 06; 273(10):5744-51. delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE. PMID: 9488707.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    45. Import and metabolism of glutathione by Streptococcus mutans. J Bacteriol. 1998 Mar; 180(6):1454-9. Sherrill C, Fahey RC. PMID: 9515913; PMCID: PMC107044.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    46. Determination of the cytoprotective agent WR-2721 (Amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography. Cancer Chemother Pharmacol. 1998; 42(5):400-6. Souid AK, Newton GL, Dubowy RL, Fahey RC, Bernstein ML. PMID: 9771955.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Effect of polyamine-induced compaction and aggregation of DNA on the formation of radiation-induced strand breaks: quantitative models for cellular radiation damage. Radiat Res. 1997 Sep; 148(3):272-84. Newton GL, Aguilera JA, Ward JF, Fahey RC. PMID: 9291359.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    48. Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei. Radiat Res. 1996 Sep; 146(3):298-305. Newton GL, Aguilera JA, Ward JF, Fahey RC. PMID: 8752308.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    49. Transport of aminothiol radioprotectors into mammalian cells: passive diffusion versus mediated uptake. Radiat Res. 1996 Aug; 146(2):206-15. Newton GL, Aguilera JA, Kim T, Ward JF, Fahey RC. PMID: 8693070.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. Glutathione amide and its perthiol in anaerobic sulfur bacteria. J Bacteriol. 1996 Aug; 178(15):4742-6. Bartsch RG, Newton GL, Sherrill C, Fahey RC. PMID: 8755912; PMCID: PMC178251.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    51. Polyamine-induced compaction and aggregation of DNA--a major factor in radioprotection of chromatin under physiological conditions. Radiat Res. 1996 Jun; 145(6):776-80. Newton GL, Aguilera JA, Ward JF, Fahey RC. PMID: 8643839.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    52. Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. J Bacteriol. 1996 Apr; 178(7):1990-5. Newton GL, Arnold K, Price MS, Sherrill C, Delcardayre SB, Aharonowitz Y, Cohen G, Davies J, Fahey RC, Davis C. PMID: 8606174; PMCID: PMC177895.
      View in: PubMed   Mentions: 184     Fields:    Translation:Cells
    53. DNA repair by thiols in air shows two radicals make a double-strand break. Radiat Res. 1995 Sep; 143(3):273-80. Milligan JR, Ng JY, Wu CC, Aguilera JA, Fahey RC, Ward JF. PMID: 7652164.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    54. The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol. Eur J Biochem. 1995 Jun 01; 230(2):821-5. Newton GL, Bewley CA, Dwyer TJ, Horn R, Aharonowitz Y, Cohen G, Davies J, Faulkner DJ, Fahey RC. PMID: 7607257.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    55. Role of charge in the radioprotection of E. coli by thiols. Int J Radiat Biol. 1995 Apr; 67(4):393-401. Prise KM, Gillies NE, Whelan A, Newton GL, Fahey RC, Michael BD. PMID: 7738402.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    56. Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Carcinogenesis. 1995 Apr; 16(4):767-74. Grdina DJ, Shigematsu N, Dale P, Newton GL, Aguilera JA, Fahey RC. PMID: 7728953.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    57. Determination of biothiols by bromobimane labeling and high-performance liquid chromatography. Methods Enzymol. 1995; 251:148-66. Newton GL, Fahey RC. PMID: 7651194.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    58. Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants. J Bacteriol. 1993 May; 175(9):2734-42. Newton GL, Fahey RC, Cohen G, Aharonowitz Y. PMID: 8478335; PMCID: PMC204577.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    59. Determination of the acid dissociation constants for WR-1065 by proton NMR spectroscopy. Radiat Res. 1992 Aug; 131(2):143-51. Newton GL, Dwyer TJ, Kim T, Ward JF, Fahey RC. PMID: 1641468.
      View in: PubMed   Mentions: 1     Fields:    
    60. Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of the net charge on the thiol. Radiat Res. 1992 May; 130(2):194-204. Aguilera JA, Newton GL, Fahey RC, Ward JF. PMID: 1574575.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    61. Aerobic radioprotection of pBR322 by thiols: effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals. Radiat Res. 1992 May; 130(2):183-93. Zheng S, Newton GL, Ward JF, Fahey RC. PMID: 1574574.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    62. para-sulfobenzoyloxybromobimane: a new membrane-impermeable reagent useful for the analysis of thiols and their export from cells. Anal Biochem. 1992 Feb 14; 201(1):30-42. Newton GL, Aguilera JA, Fahey RC, Ward JF, Radkowsky AE, Kosower EM. PMID: 1621960.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    63. The role of charge in intracellular radioprotection by thiols. BJR Suppl. 1992; 24:32-4. Gillies NE, Prise KM, Michael BD, Fahey RC. PMID: 1290708.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    64. The effects of counter-ion condensation and co-ion depletion upon the rates of chemical repair of poly(U) radicals by thiols. Int J Radiat Biol. 1991 Apr; 59(4):885-99. Fahey RC, Vojnovic B, Michael BD. PMID: 1674274.
      View in: PubMed   Mentions: 1     Fields:    
    65. Rates for repair of pBR 322 DNA radicals by thiols as measured by the gas explosion technique: evidence that counter-ion condensation and co-ion depletion are significant at physiological ionic strength. Int J Radiat Biol. 1991 Apr; 59(4):901-17. Fahey RC, Prise KM, Stratford MR, Watfa RR, Michael BD. PMID: 1674275.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    66. Evolution of glutathione metabolism. Adv Enzymol Relat Areas Mol Biol. 1991; 64:1-53. Fahey RC, Sundquist AR. PMID: 1675828.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    67. Nuclear thiols: technical limitations on the determination of endogenous nuclear glutathione and the potential importance of sulfhydryl proteins. Radiat Res. 1990 Jan; 121(1):98-106. Loh SN, Dethlefsen LA, Newton GL, Aguilera JA, Fahey RC. PMID: 2300674.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    68. Evolution of antioxidant mechanisms: thiol-dependent peroxidases and thioltransferase among procaryotes. J Mol Evol. 1989 Nov; 29(5):429-35. Sundquist AR, Fahey RC. PMID: 2515292.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    69. The function of gamma-glutamylcysteine and bis-gamma-glutamylcystine reductase in Halobacterium halobium. J Biol Chem. 1989 Jan 15; 264(2):719-25. Sundquist AR, Fahey RC. PMID: 2910862.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    70. The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes. J Bacteriol. 1988 Aug; 170(8):3459-67. Sundquist AR, Fahey RC. PMID: 3136140; PMCID: PMC211315.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    71. Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug. Cancer Res. 1988 Jul 01; 48(13):3634-40. Calabro-Jones PM, Aguilera JA, Ward JF, Smoluk GD, Fahey RC. PMID: 2837319.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    72. Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection. Cancer Res. 1988 Jul 01; 48(13):3641-7. Smoluk GD, Fahey RC, Calabro-Jones PM, Aguilera JA, Ward JF. PMID: 2837320.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    73. Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA. Radiat Res. 1988 Apr; 114(1):11-27. Zheng S, Newton GL, Gonick G, Fahey RC, Ward JF. PMID: 3127858.
      View in: PubMed   Mentions: 14     Fields:    
    74. Interaction of glutathione and other low-molecular-weight thiols with DNA: evidence for counterion condensation and coion depletion near DNA. Radiat Res. 1988 Apr; 114(1):3-10. Smoluk GD, Fahey RC, Ward JF. PMID: 3127859.
      View in: PubMed   Mentions: 3     Fields:    
    75. Protection of DNA by thiols. Pharmacol Ther. 1988; 39(1-3):101-8. Fahey RC. PMID: 3059361.
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    76. Determination of low-molecular-weight thiols using monobromobimane fluorescent labeling and high-performance liquid chromatography. Methods Enzymol. 1987; 143:85-96. Fahey RC, Newton GL. PMID: 3657565.
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    77. Purification of thiols from biological samples. Methods Enzymol. 1987; 143:96-101. Newton GL, Fahey RC. PMID: 3657566.
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    78. The evolution of glutathione metabolism in phototrophic microorganisms. J Mol Evol. 1987; 25:81-8. Fahey RC, Buschbacher RM, Newton GL. PMID: 11542078.
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    79. Determination of thiol proteins using monobromobimane labeling and high-performance liquid chromatographic analysis: application to Escherichia coli thioredoxin. Anal Biochem. 1986 Nov 15; 159(1):143-9. Chinn PC, Pigiet V, Fahey RC. PMID: 3544950.
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    80. Equilibrium dialysis studies of the binding of radioprotector compounds to DNA. Radiat Res. 1986 Aug; 107(2):194-204. Smoluk GD, Fahey RC, Ward JF. PMID: 3018831.
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    81. Analysis of biological thiols: determination of thiol components of disulfides and thioesters. Anal Biochem. 1986 Apr; 154(1):34-42. Fenton SS, Fahey RC. PMID: 2939769.
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    82. Measurement of WR-2721, WR-1065, and WR-33278 in plasma. Int J Radiat Oncol Biol Phys. 1985 Jun; 11(6):1193-7. Fahey RC, Newton GL. PMID: 2987166.
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    83. Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721. Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Jan; 47(1):23-7. Calabro-Jones PM, Fahey RC, Smoluk GD, Ward JF. PMID: 2982751.
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    84. Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721. Int J Radiat Oncol Biol Phys. 1984 Sep; 10(9):1525-8. Utley JF, Seaver N, Newton GL, Fahey RC. PMID: 6090355.
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    85. Entamoeba histolytica: a eukaryote without glutathione metabolism. Science. 1984 Apr 06; 224(4644):70-2. Fahey RC, Newton GL, Arrick B, Overdank-Bogart T, Aley SB. PMID: 6322306.
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    86. Levels of sulfhydryls and disulfides in proteins from Neurospora crassa conidia and mycelia. J Bacteriol. 1983 Nov; 156(2):703-9. Brody S, Mikolajczyk SD, Fahey RC. PMID: 6226648; PMCID: PMC217886.
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    87. Analysis of biological thiols: derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography. Anal Biochem. 1981 Jul 01; 114(2):383-7. Newton GL, Dorian R, Fahey RC. PMID: 7304929.
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    88. Analysis of biological thiols: quantitative determination of thiols at the picomole level based upon derivatization with monobromobimanes and separation by cation-exchange chromatography. Anal Biochem. 1981 Mar 01; 111(2):357-65. Fahey RC, Newton GL, Dorian R, Kosower EM. PMID: 7247030.
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    89. Analysis of biological thiols: derivatization with monobromotrimethylammoniobimane and characterization by electrophoresis and chromatography. Anal Biochem. 1980 Sep 01; 107(1):1-10. Fahey RC, Newton GL, Dorian R, Kosower EM. PMID: 6449160.
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    90. Role of hydration state and thiol-disulfide status in the control of thermal stability and protein synthesis in wheat embryo. Plant Physiol. 1980 Jun; 65(6):1062-6. Fahey RC, Di Stefano DL, Meier GP, Bryan RN. PMID: 16661331; PMCID: PMC440481.
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    91. Correlation of enzymatic activity and thermal resistance with hydration state in ungerminated Neurospora conidia. J Bacteriol. 1978 Sep; 135(3):868-75. Fahey RC, Mikolajczyk SD, Brody S. PMID: 151096; PMCID: PMC222458.
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    92. Occurrence of glutathione in bacteria. J Bacteriol. 1978 Mar; 133(3):1126-9. Fahey RC, Brown WC, Adams WB, Worsham MB. PMID: 417060; PMCID: PMC222142.
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    93. On the cysteine and cystine content of proteins. Differences between intracellular and extracellular proteins. J Mol Evol. 1977 Nov 25; 10(2):155-60. Fahey RC, Hunt JS, Windham GC. PMID: 592421.
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    94. The glutathione thiol-disulfide status in the sea urchin egg during fertilization and the first cell division cycle. Biochim Biophys Acta. 1976 Jul 21; 437(2):445-53. Fahey RC, Mikolajczyk SD, Meier GP, Epel D, Carroll EJ. PMID: 952928.
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    95. Changes in the glutathione thiol-disulfide status of Neurospora crassa conidia during germination and aging. J Bacteriol. 1975 Jan; 121(1):144-51. Fahey RC, Brody S, Mikolajczyk SD. PMID: 123243; PMCID: PMC285624.
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    96. A nonenzyme-coupled assay for triosephosphate isomerase based upon circular dichroism of glyceraldehyde-3-phosphate. Anal Biochem. 1974 Feb; 57(2):547-54. Fahey RC, Fischer EF. PMID: 4819742.
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