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    Hiroyuki Okano

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0374
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yasukawa K, Iida K, Okano H, Hidese R, Baba M, Yanagihara I, Kojima K, Takita T, Fujiwara S. Next-generation sequencing-based analysis of reverse transcriptase fidelity. Biochem Biophys Res Commun. 2017 Oct 14; 492(2):147-153. PMID: 28778390.
        View in: PubMed
      2. Okano H, Baba M, Yamasaki T, Hidese R, Fujiwara S, Yanagihara I, Ujiiye T, Hayashi T, Kojima K, Takita T, Yasukawa K. High sensitive one-step RT-PCR using MMLV reverse transcriptase, DNA polymerase with reverse transcriptase activity, and DNA/RNA helicase. Biochem Biophys Res Commun. 2017 May 20; 487(1):128-133. PMID: 28400277.
        View in: PubMed
      3. Okano H, Katano Y, Baba M, Fujiwara A, Hidese R, Fujiwara S, Yanagihara I, Hayashi T, Kojima K, Takita T, Yasukawa K. Enhanced detection of RNA by MMLV reverse transcriptase coupled with thermostable DNA polymerase and DNA/RNA helicase. Enzyme Microb Technol. 2017 Jan; 96:111-120. PMID: 27871370.
        View in: PubMed
      4. Katano Y, Hisayoshi T, Kuze I, Okano H, Ito M, Nishigaki K, Takita T, Yasukawa K. Expression of moloney murine leukemia virus reverse transcriptase in a cell-free protein expression system. Biotechnol Lett. 2016 Jul; 38(7):1203-11. PMID: 27053084.
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      5. Basan M, Hui S, Okano H, Zhang Z, Shen Y, Williamson JR, Hwa T. Overflow metabolism in Escherichia coli results from efficient proteome allocation. Nature. 2015 Dec 2; 528(7580):99-104. PMID: 26632588.
        View in: PubMed
      6. Hermsen R, Okano H, You C, Werner N, Hwa T. A growth-rate composition formula for the growth of E.coli on co-utilized carbon substrates. Mol Syst Biol. 2015 Apr 09; 11(4):801. PMID: 25862745; PMCID: PMC4422558.
      7. Okano H, Kanaya E, Ozaki M, Angkawidjaja C, Kanaya S. Structure, activity, and stability of metagenome-derived glycoside hydrolase family 9 endoglucanase with an N-terminal Ig-like domain. Protein Sci. 2015 Mar; 24(3):408-19. PMID: 25545469; PMCID: PMC4353366.
      8. Okano H, Hong X, Kanaya E, Angkawidjaja C, Kanaya S. Structural and biochemical characterization of a metagenome-derived esterase with a long N-terminal extension. Protein Sci. 2015 Jan; 24(1):93-104. PMID: 25348365; PMCID: PMC4282415.
      9. Okano H, Ozaki M, Kanaya E, Kim JJ, Angkawidjaja C, Koga Y, Kanaya S. Structure and stability of metagenome-derived glycoside hydrolase family 12 cellulase (LC-CelA) a homolog of Cel12A from Rhodothermus marinus. FEBS Open Bio. 2014; 4:936-46. PMID: 25426413; PMCID: PMC4239480.
      10. Deris JB, Kim M, Zhang Z, Okano H, Hermsen R, Groisman A, Hwa T. The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria. Science. 2013 Nov 29; 342(6162):1237435. PMID: 24288338; PMCID: PMC4059556.
      11. You C, Okano H, Hui S, Zhang Z, Kim M, Gunderson CW, Wang YP, Lenz P, Yan D, Hwa T. Coordination of bacterial proteome with metabolism by cyclic AMP signalling. Nature. 2013 Aug 15; 500(7462):301-6. PMID: 23925119; PMCID: PMC4038431.
      12. Kim M, Zhang Z, Okano H, Yan D, Groisman A, Hwa T. Need-based activation of ammonium uptake in Escherichia coli. Mol Syst Biol. 2012; 8:616. PMID: 23010999; PMCID: PMC3472687.
      13. Okano H, Hwa T, Lenz P, Yan D. Reversible adenylylation of glutamine synthetase is dynamically counterbalanced during steady-state growth of Escherichia coli. J Mol Biol. 2010 Dec 03; 404(3):522-36. PMID: 20887734.
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      14. Hata N, Murata S, Maeda J, Yatani H, Kohno Y, Yokono K, Okano H. Predictors of gastric myoelectrical activity in type 2 diabetes mellitus. J Clin Gastroenterol. 2009 May-Jun; 43(5):429-36. PMID: 19564814.
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      15. Saito A, Sato T, Okano H, Toyoda K, Bamba H, Kimura S, Bellier JP, Matsuo A, Kimura H, Hisa Y, Tooyama I. Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve. J Comp Neurol. 2009 Mar 10; 513(2):237-48. PMID: 19137611.
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      16. Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, Goda HM, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, Ito M. Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. J Biol Chem. 2009 Apr 03; 284(14):9566-77. PMID: 19088069; PMCID: PMC2666609.
      17. Kameno M, Takata T, Yasuda H, Hara K, Okano H, Sakurai T, Nagata M, Yokono K. [A case of elderly onset loss of consciousness due to bacterial meningitis and subsequent vasculitis]. Nihon Ronen Igakkai Zasshi. 2008 Jul; 45(4):434-8. PMID: 18753720.
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      18. Okano H, Kobayashi TJ, Tozaki H, Kimura H. Estimation of the source-by-source effect of autorepression on genetic noise. Biophys J. 2008 Aug; 95(3):1063-74. PMID: 18390607; PMCID: PMC2479612.
      19. Tozaki H, Kobayashi TJ, Okano H, Yamamoto R, Aihara K, Kimura H. Reconstructing the single-cell-level behavior of a toggle switch from population-level measurements. FEBS Lett. 2008 Apr 02; 582(7):1067-72. PMID: 18325334.
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      20. Shimada T, Okano H, Hisa Y. A case of severe dilatation of the parotid duct due to fibrinous sialodochitis. Acta Otolaryngol. 2006 Oct; 126(10):1112-4. PMID: 16923720.
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      21. Ohji G, Nagata M, Hara K, Matsuzawa T, Hata N, Yasuda H, Sakurai T, Okano H, Yokono K. [Group B streptococcal vertebral osteomyelitis following superficial suppurative thrombophlebitis]. Nihon Ronen Igakkai Zasshi. 2006 Sep; 43(5):635-8. PMID: 17073295.
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      22. Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I. Localization of fibroblast growth factor-1 in cholinergic neurons innervating the rat larynx. J Histochem Cytochem. 2006 Sep; 54(9):1061-71. PMID: 16735594.
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      23. Tanaka RJ, Okano H, Kimura H. Mathematical description of gene regulatory units. Biophys J. 2006 Aug 15; 91(4):1235-47. PMID: 16714341; PMCID: PMC1518624.
      24. Nishio T, Koike S, Okano H, Bamba H, Hisa Y. Age-related expression of alpha-gustducin in the rat larynx. Ann Otol Rhinol Laryngol. 2006 May; 115(5):387-93. PMID: 16739672.
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      25. Okano H, Koike S, Bamba H, Toyoda K, Uno T, Hisa Y. Participation of TRPV1 and TRPV2 in the rat laryngeal sensory innervation. Neurosci Lett. 2006 May 29; 400(1-2):35-8. PMID: 16517068.
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      26. Toyoda K, Okano H, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Tooyama I. Comparison of FGF1 (aFGF) expression between the dorsal motor nucleus of vagus and the hypoglossal nucleus of rat. Acta Histochem Cytochem. 2006 Mar 02; 39(1):1-7. PMID: 17460766; PMCID: PMC1831852.
      27. Bamba H, Hirasugi K, Okano H, Nishio T, Uno T, Hisa Y. A newborn case of congenital laryngeal cyst complicated with pneumothorax and pneumomediastinum. Auris Nasus Larynx. 2006 Jun; 33(2):207-10. PMID: 16356675.
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      28. Koike S, Uno T, Bamba H, Shibata T, Okano H, Hisa Y. Distribution of vanilloid receptors in the rat laryngeal innervation. Acta Otolaryngol. 2004 May; 124(4):515-9. PMID: 15224886.
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      29. Okano H, Asakawa M, Ohya Y. A novel mechanism of intragenic complementation between Phe to Ala calmodulin mutations. J Biochem. 2004 Mar; 135(3):289-95. PMID: 15113827.
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