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    Harry Bluestein

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0656
    CA La Jolla 92093
    Phone858-534-2359
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      Collapse Biography 
      Collapse Education and Training
      National Institute of Allergy and Infectious DiseasesFellowship, Immunology
      Harvard Medical School , Boston, MAFellowship, Pathology
      Albert Einstein College of Medicine, Yeshiva University, Bronx, NYMD

      Collapse Overview 
      Collapse Overview
      Research Interests

      The identification and characterization of cell membrane molecules that serve as targets of systemic lupus erythematosus antibodies and on the role of those antibodies in the pathogenesis of SLE, particularly the neuropsychiatric manifestations.


      Collapse Research 
      Collapse Research Activities and Funding
      MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASE CENTER
      NIH/NIAMS P60AR040770Aug 1, 1991 - Feb 28, 2002
      Role: Principal Investigator
      SLE ANTIBODIES TO NEURONS &LYMPHOCYTES--PATHOBIOLOGY
      NIH/NIAMS R01AR030036Jul 1, 1981 - Mar 31, 1994
      Role: Principal Investigator
      SLE ANTIBODIES TO NEURONS AND LYMPHOCYTES: PATHOBIOLOGY
      NIH/NIADDK R01AM030036Jul 1, 1981 - Mar 31, 1987
      Role: Principal Investigator
      CELLULAR CONTROL OF EB VIRUS IN RHEUMATOID ARTHRITIS
      NIH/NIAMS R01AR025719Dec 1, 1979 - Nov 30, 1991
      Role: Principal Investigator
      CELLULAR CONTROL OF EB VIRUS IN RHEUMATOID ARTHRITIS
      NIH/NIADDK R01AM025719Dec 1, 1979 - Nov 30, 1985
      Role: Principal Investigator
      RHEUMATIC DISEASES
      NIH/NIAMS T32AR007062Jul 1, 1975 - Sep 30, 1998
      Role: Principal Investigator

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Ceponis A, Onishi M, Bluestein H, Kalunian K, Townsend J, Kavanaugh A. Utility of the ultrasound examination of the hand and wrist joints in the management of established rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014 Feb; 66(2):236-44. PMID: 23983173.
        View in: PubMed
      2. Porter-Williamson K, von Gunten CF, Garman K, Herbst L, Bluestein H, Evans W. Improving knowledge in palliative medicine with a required hospice rotation for third-year medical students. Acad Med. 2004 Aug; 79(8):777-82. PMID: 15277135.
        View in: PubMed
      3. Weisman MH, Bluestein H, Berner CM, de Haan HA. Reduction in circulating dsDNA antibody titer after administration of LJP 394. J Rheumatol. 1997 Feb; 24(2):314-8. PMID: 9034989.
        View in: PubMed
      4. Spezialetti R, Bluestein H, Peter JB, Alexander EL. Neuropsychiatric disease in Sjögren's syndrome: anti-ribosomal P and anti-neuronal antibodies. Am J Med. 1993 Aug; 95(2):153-60. PMID: 8356981.
        View in: PubMed
      5. Corbel C, Cormier F, Pourquie O, Bluestein H. BEN, a novel surface molecule of the immunoglobulin superfamily on avian hemopoietic progenitor cells shared with neural cells. Exp Cell Res. 1992 Nov; 203(1):91-9. PMID: 1426054.
        View in: PubMed
      6. Corbel C, Bluestein H, Pourquie O, Vaigot P, Le Douarin NM. An antigen expressed by avian neuronal cells is also expressed by activated T lymphocytes. Cell Immunol. 1992 Apr 15; 141(1):99-110. PMID: 1372844.
        View in: PubMed
      7. Papero PH, Bluestein H, White P, Lipnick RN. Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythematosus. Clin Exp Rheumatol. 1990 Jul-Aug; 8(4):417-24. PMID: 2397630.
        View in: PubMed
      8. Woods VL, Pischel KD, Avery ED, Bluestein H. Antigenic polymorphism of human very late activation protein-2 (platelet glycoprotein Ia-IIa). Platelet alloantigen Hca. J Clin Invest. 1989 Mar; 83(3):978-85. PMID: 2646323; PMCID: PMC303774.
        View in: PubMed, PubMed Central
      9. Bluestein H. Anatomic and genetic considerations in the pathogenesis of ankylosing spondylitis. J Rheumatol Suppl. 1988 Sep; 16:29-32. PMID: 3057208.
        View in: PubMed
      10. Laubscher A, Bluestein H, Spector SA, Zvaifler NJ. Generation of human cytomegalovirus-specific cytotoxic T-lymphocytes in a short-term culture. J Immunol Methods. 1988 May 25; 110(1):69-77. PMID: 2836515.
        View in: PubMed
      11. Pischel KD, Bluestein H, Woods VL. Platelet glycoproteins Ia, Ic, and IIa are physicochemically indistinguishable from the very late activation antigens adhesion-related proteins of lymphocytes and other cell types. J Clin Invest. 1988 Feb; 81(2):505-13. PMID: 3276732; PMCID: PMC329598.
        View in: PubMed, PubMed Central
      12. Gilman SC, Bluestein H. Effects of tilomisole, indomethacin and levamisole on regulation of Epstein Barr virus-induced B cell proliferation by peripheral blood mononuclear cells from normal individuals and patients with rheumatoid arthritis. Agents Actions. 1987 Aug; 21(3-4):266-8. PMID: 2825478.
        View in: PubMed
      13. Bluestein H. Neuropsychiatric manifestations of systemic lupus erythematosus. N Engl J Med. 1987 Jul 30; 317(5):309-11. PMID: 3600721.
        View in: PubMed
      14. Pischel KD, Marlin SD, Springer TA, Woods VL, Bluestein H. Polymorphism of lymphocyte function-associated antigen-1 demonstrated by a lupus patient's alloantiserum. J Clin Invest. 1987 Jun; 79(6):1607-14. PMID: 2438304; PMCID: PMC424480.
        View in: PubMed, PubMed Central
      15. Pischel KD, Hemler ME, Huang C, Bluestein H, Woods VL. Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2. J Immunol. 1987 Jan 01; 138(1):226-33. PMID: 3023488.
        View in: PubMed
      16. Konttinen YT, Bluestein H, Zvaifler NJ. Regulation of the growth of Epstein-Barr virus-infected B cells: temporal profile of the in vitro development of three distinct cytotoxic cells. Cell Immunol. 1986 Nov; 103(1):84-95. PMID: 3026657.
        View in: PubMed
      17. Pischel KD, Bluestein H, Woods VL. Very late activation antigens (VLA) are human leukocyte-neuronal crossreactive cell surface antigens. J Exp Med. 1986 Aug 01; 164(2):393-406. PMID: 2425033; PMCID: PMC2188224.
        View in: PubMed, PubMed Central
      18. Markman M, Lim HW, Bluestein H. Vancomycin-induced vasculitis. South Med J. 1986 Mar; 79(3):382-3. PMID: 2937155.
        View in: PubMed
      19. Gruber HE, Cohen AH, Firestein GS, Redelman D, Bluestein H. Deoxy-ATP accumulation in adenosine deaminase-inhibited human B and T lymphocytes. Adv Exp Med Biol. 1986; 195 Pt A:503-7. PMID: 3487921.
        View in: PubMed
      20. Bluestein H, Pischel KD, Woods VL. Immunopathogenesis of the neuropsychiatric manifestations of systemic lupus erythematosus. Springer Semin Immunopathol. 1986; 9(2-3):237-49. PMID: 3027907.
        View in: PubMed
      21. Konttinen YT, Bluestein H, Zvaifler NJ. Regulation of the growth of Epstein-Barr virus-infected B cells. I. Growth regression by E rosetting cells from VCA-positive donors is a combined effect of autologous mixed leukocyte reaction and activation of T8+ memory cells. J Immunol. 1985 Apr; 134(4):2287-93. PMID: 2857749.
        View in: PubMed
      22. Albert D, Bluestein H, Willis RC, Nette K, Seegmiller JE. The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of purine-nucleoside phosphorylase deficiency. Cell Immunol. 1984 Jul; 86(2):501-9. PMID: 6428752.
        View in: PubMed
      23. Albert D, Bluestein H, Thompson L, Seegmiller JE. The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of adenosine deaminase deficiency. Cell Immunol. 1984 Jul; 86(2):510-7. PMID: 6610485.
        View in: PubMed
      24. Cohen AH, Bluestein H, Redelman D. Deoxyadenosine modulates human suppressor T cell function and B cell differentiation stimulated by Staphylococcus aureus protein A. J Immunol. 1984 Apr; 132(4):1761-6. PMID: 6199411.
        View in: PubMed
      25. Redelman D, Bluestein H, Cohen AH, Depper JM, Wormsley S. Deoxyadenosine (AdR) inhibition of newly activated lymphocytes: blockade at the G0-G1 interface. J Immunol. 1984 Apr; 132(4):2030-8. PMID: 6421932.
        View in: PubMed
      26. Albert DA, Bluestein H. DNA synthesis inhibitors block protein synthesis in the human lymphocyte. Int J Immunopharmacol. 1984; 6(2):147-53. PMID: 6203850.
        View in: PubMed
      27. Bluestein H, Hasler F. Epstein-Barr virus and rheumatoid arthritis. Surv Immunol Res. 1984; 3(1):70-7. PMID: 6326237.
        View in: PubMed
      28. Goto M, Bluestein H, Zvaifler NJ. Panning separation for monoclonal antibody-specific T-cell subsets: effects of enzymes and metabolic inhibitors. Microbiol Immunol. 1984; 28(12):1373-84. PMID: 6398396.
        View in: PubMed
      29. Hasler F, Bluestein H, Zvaifler NJ, Epstein LB. Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E. J Immunol. 1983 Aug; 131(2):768-72. PMID: 6306107.
        View in: PubMed
      30. Hasler F, Bluestein H, Zvaifler NJ, Epstein LB. Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation. J Exp Med. 1983 Jan 01; 157(1):173-88. PMID: 6294213; PMCID: PMC2186886.
        View in: PubMed, PubMed Central
      31. Bluestein H, Woods VL. Antineuronal antibodies in systemic lupus erythematosus. Arthritis Rheum. 1982 Jul; 25(7):773-8. PMID: 7104053.
        View in: PubMed
      32. Zvaifler NJ, Bluestein H. The pathogenesis of central nervous system manifestations of systemic lupus erythematosus. Arthritis Rheum. 1982 Jul; 25(7):862-6. PMID: 7104058.
        View in: PubMed
      33. Depper JM, Zvaifler NJ, Bluestein H. Oropharyngeal Epstein-Barr virus excretion in rheumatoid arthritis. Arthritis Rheum. 1982 Apr; 25(4):427-31. PMID: 6280734.
        View in: PubMed
      34. Depper JM, Bluestein H, Zvaifler NJ. Impaired regulation of Epstein-Barr virus-induced lymphocyte proliferation in rheumatoid arthritis is due to a T cell defect. J Immunol. 1981 Nov; 127(5):1899-902. PMID: 6271870.
        View in: PubMed
      35. Bluestein H, Redelman D, Zvaifler NJ. Procainamide-lymphocyte reactions. A possible explanation for drug-induced autoimmunity. Arthritis Rheum. 1981 Aug; 24(8):1019-23. PMID: 6169349.
        View in: PubMed
      36. Bluestein H, Williams GW, Steinberg AD. Cerebrospinal fluid antibodies to neuronal cells: association with neuropsychiatric manifestations of systemic lupus erythematosus. Am J Med. 1981 Feb; 70(2):240-6. PMID: 7468611.
        View in: PubMed
      37. Williams GW, Bluestein H, Steinberg AD. Brain-reactive lymphocytotoxic antibody in the cerebrospinal fluid of patients with systemic lupus erythematosus: correlation with central nervous system involvement. Clin Immunol Immunopathol. 1981 Jan; 18(1):126-32. PMID: 7460395.
        View in: PubMed
      38. Bardwick PA, Bluestein H, Zvaifler NJ, Depper JM, Seegmiller JE. Altered regulation of Epstein-Barr virus induced lymphoblast proliferation in rheumatoid arthritis lymphoid cells. Arthritis Rheum. 1980 Jun; 23(6):626-32. PMID: 6248075.
        View in: PubMed
      39. Bluestein H, Thompson LF, Albert DA, Seegmiller JE. Altered deoxynucleoside triphosphate levels paralleling deoxyadenosine toxicity in adenosine deaminase inhibited human lymphocytes. Adv Exp Med Biol. 1980; 122A:427-31. PMID: 6968502.
        View in: PubMed
      40. Bluestein H, Zvaifler NJ, Weisman MH, Shapiro RF. Lymphocyte alteration by procainamide: relation to drug-induced lupus erythematosus syndrome. Lancet. 1979 Oct 20; 2(8147):816-9. PMID: 90917.
        View in: PubMed
      41. Zvaifler NJ, Bluestein H. Antibody-mediated suppression of antibody-dependent cytotoxic effector cell function. Clin Immunol Immunopathol. 1979 Jul; 13(3):277-86. PMID: 88291.
        View in: PubMed
      42. Bluestein H. Heterogeneous neurocytotoxic antibodies in systemic lupus erythematosus. Clin Exp Immunol. 1979 Feb; 35(2):210-7. PMID: 436335; PMCID: PMC1537650.
        View in: PubMed, PubMed Central
      43. Klippel JH, Bluestein H, Zvaifler NJ. Lymphocyte reactivity of antisera to cryoproteins in systemic lupus erythematosus. Clin Immunol Immunopathol. 1979 Jan; 12(1):52-61. PMID: 570468.
        View in: PubMed
      44. Bluestein H. Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1978 Aug; 75(8):3965-9. PMID: 279013; PMCID: PMC392910.
        View in: PubMed, PubMed Central
      45. Greenberg PD, Bluestein H. Antigen recognition by primed T lymphocytes in vitro. I. Separation of recognitive and proliferative phases of antigen-induced T cell activation. J Immunol. 1978 Jul; 121(1):239-44. PMID: 307572.
        View in: PubMed
      46. Curd JG, Sundsmo JS, Kolb WP, Bluestein H, Müller-Eberhard HJ. Neoantigen of the membrane attack complex of human complement: Occurrence on peripheral blood leukocytes from patients with systemic lupus erythematosus. Arthritis Rheum. 1978 Mar; 21(2):177-82. PMID: 76471.
        View in: PubMed
      47. Meyer-Hamme S, Bluestein H. Antibody-mediated suppression of bone marrow colony formation in vitro. J Cell Physiol. 1978 Jan; 94(1):47-56. PMID: 304065.
        View in: PubMed
      48. Bluestein H, Willis RC, Thompson LF, Matsumoto S, Seegmiller JE. Accumulation of deoxyribonucleotides as a possible mediator of immunosuppression in hereditary deficiency of adenosine deaminase. Trans Assoc Am Physicians. 1978; 91:394-402. PMID: 314193.
        View in: PubMed
      49. Zvaifler NJ, Bluestein H. Lymphocytotoxic antibody activity in cryoprecipitates from serum of patients with SLE. Arthritis Rheum. 1976 Sep-Oct; 19(5):844-50. PMID: 1085625.
        View in: PubMed
      50. Utsinger PD, Zvaifler NJ, Bluestein H. Hypocomplementemia in procainamide-associated systemic lupus erythematosus. Ann Intern Med. 1976 Mar; 84(3):293. PMID: 1259265.
        View in: PubMed
      51. Bluestein H, Zvaifler NJ. Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest. 1976 Feb; 57(2):509-16. PMID: 56343; PMCID: PMC436676.
        View in: PubMed, PubMed Central
      52. Greenberg PD, Bluestein H. Alloantiserum-mediated supperssion of Ir gene controlled antigen-induced lymphocyte activation: effect on uridine and leucine incorporation. J Immunol. 1975 Nov; 115(5):1206-11. PMID: 1176772.
        View in: PubMed
      53. Bluestein H. Alloantiserum-mediated suppression of histocompatibility-linked IR gene controlled immune responses. I. Histocompatibility antigen requirement. J Immunol. 1974 Nov; 113(5):1410-6. PMID: 4417776.
        View in: PubMed
      54. Bluestein H. Alloantiserum-mediated suppression of histocompatibility-linked Ir-gene-controlled immune responses. Suppressive effects of IgG fragments derived from alloantisera. J Exp Med. 1974 Aug 01; 140(2):481-93. PMID: 4846415; PMCID: PMC2139598.
        View in: PubMed, PubMed Central
      55. Bluestein H, Pierce CW. Development of primary M, G, and A anti-TNP plaque-forming cell responses in vitro. J Immunol. 1973 Jul; 111(1):130-6. PMID: 4576584.
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      56. Bluestein H, Pierce CW. Cellular requirements for development of primary anti-hapten antibody responses in vitro. J Immunol. 1973 Jul; 111(1):137-42. PMID: 4123367.
        View in: PubMed
      57. Bluestein H, Green I, Maurer PH, Benacerraf B. Specific immune response genes of the guinea pig. V. Influence of the GA and GT immune response genes on the specificity of cellular and humoral immune responses to a terpolymer of L-glutamic acid, L-alanine, and L-tyrosine. J Exp Med. 1972 Jan; 135(1):98-109. PMID: 5009706; PMCID: PMC2139119.
        View in: PubMed, PubMed Central
      58. Bluestein H, Ellman L, Green I, Benacerraf B. Specific immune response genes of the guinea pig. 3. Linkage of the GA and GT immune response genes to histocompatibility genotypes in inbred guinea pigs. J Exp Med. 1971 Dec 01; 134(6):1529-37. PMID: 5126638; PMCID: PMC2139104.
        View in: PubMed, PubMed Central
      59. Bluestein H, Green I, Benacerraf B. Histocompatibility specificity. J Exp Med. 1971 Dec 01; 134(6):1538-44. PMID: 5126639; PMCID: PMC2139109.
        View in: PubMed, PubMed Central
      60. Bluestein H, Green I, Benacerraf B. Specific immune response genes of the guinea pig. I. Dominant genetic control of immune responsiveness to copolymers of L-glutamic acid and L-alanine and L-glutamic acid and L-tyrosine. J Exp Med. 1971 Aug 01; 134(2):458-70. PMID: 5559610; PMCID: PMC2139052.
        View in: PubMed, PubMed Central
      61. Bluestein H, Green I, Benacerraf B. Specific immune response genes of the guinea pig. II. Relationship between the poly-L-lysine gene and the genes controlling immune responsiveness to copolymers of L-glutamic acid and L-alanine and L-glutamic acid and L-tyrosine in random-bred Hartley guinea pigs. J Exp Med. 1971 Aug 01; 134(2):471-81. PMID: 5559611; PMCID: PMC2139044.
        View in: PubMed, PubMed Central
      62. Katz DH, Bluestein H, Rouques RJ, Pierce CW. Anti-TNP antibody responses in vitro: augmented primary responses of carrier-primed spleen cells. J Immunol. 1971 Jan; 106(1):271-3. PMID: 5101180.
        View in: PubMed
      63. Bluestein H, Green I. Croton oil induced suppression of the immune response of guinea-pigs. Nature. 1970 Nov 28; 228(5274):871-2. PMID: 5477020.
        View in: PubMed
      64. Bluestein H, Green I, Benacerraf B. The inability of RNA from lymph node cells from immunized strain 2 animals to confer immune competence to strain 13 lymph node cells in the DNP-PLL immune system. Proc Soc Exp Biol Med. 1970 Oct; 135(1):146-50. PMID: 5529148.
        View in: PubMed
      65. Bluestein H, Allende CC, Allende JE, Cantoni GL. Seryl transfer ribonucleic acid synthetase from bakers' yeast. 3. The seryladenylate-enzyme complex and its interaction with transfer ribonucleic acids. J Biol Chem. 1968 Sep 25; 243(18):4693-9. PMID: 4879089.
        View in: PubMed
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