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    Douglass Forbes

    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0347
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      NIH/NIGMS R13GM051121Feb 13, 1994 - Feb 12, 1995
      Role: Principal Investigator
      Functional Study of Native and Synthetic Nuclei
      NIH/NIGMS R01GM033279Apr 1, 1984 - Apr 30, 2016
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Forbes D, Travesa A, Nord MS, Bernis C. Reprint of "Nuclear transport factors: global regulation of mitosis". Curr Opin Cell Biol. 2015 Jun; 34:122-34. PMID: 26196321.
        View in: PubMed
      2. Forbes D, Travesa A, Nord MS, Bernis C. Nuclear transport factors: global regulation of mitosis. Curr Opin Cell Biol. 2015 Aug; 35:78-90. PMID: 25982429; PMCID: PMC4529785.
      3. Schwartz M, Travesa A, Martell SW, Forbes D. Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin. Nucleus. 2015; 6(1):40-54. PMID: 25602437; PMCID: PMC4615246.
      4. Bernis C, Swift-Taylor B, Nord M, Carmona S, Chook YM, Forbes D. Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration. Mol Biol Cell. 2014 Apr; 25(7):992-1009. PMID: 24478460; PMCID: PMC3967982.
      5. Bernis C, Forbes D. Analysis of nuclear reconstitution, nuclear envelope assembly, and nuclear pore assembly using Xenopus in vitro assays. Methods Cell Biol. 2014; 122:165-91. PMID: 24857730; PMCID: PMC4454467.
      6. Powers MA, Forbes D. Nuclear transport: beginning to gel? Curr Biol. 2012 Dec 04; 22(23):R1006-9. PMID: 23218007.
        View in: PubMed
      7. Fichtman B, Ramos C, Rasala B, Harel A, Forbes D. Inner/Outer nuclear membrane fusion in nuclear pore assembly: biochemical demonstration and molecular analysis. Mol Biol Cell. 2010 Dec; 21(23):4197-211. PMID: 20926687; PMCID: PMC2993748.
      8. Lachish-Zalait A, Lau CK, Fichtman B, Zimmerman E, Harel A, Gaylord MR, Forbes D, Elbaum M. Transportin mediates nuclear entry of DNA in vertebrate systems. Traffic. 2009 Oct; 10(10):1414-28. PMID: 19761539; PMCID: PMC3073982.
      9. Lau CK, Delmar VA, Chan RC, Phung Q, Bernis C, Fichtman B, Rasala BA, Forbes D. Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly. Mol Biol Cell. 2009 Sep; 20(18):4043-58. PMID: 19641022; PMCID: PMC2743623.
      10. Chakraborty P, Wang Y, Wei JH, van Deursen J, Yu H, Malureanu L, Dasso M, Forbes D, Levy DE, Seemann J, Fontoura BM. Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell. 2008 Nov; 15(5):657-67. PMID: 19000832; PMCID: PMC2835575.
      11. Rasala BA, Ramos C, Harel A, Forbes D. Capture of AT-rich chromatin by ELYS recruits POM121 and NDC1 to initiate nuclear pore assembly. Mol Biol Cell. 2008 Sep; 19(9):3982-96. PMID: 18596237; PMCID: PMC2526682.
      12. Delmar VA, Chan RC, Forbes D. Xenopus importin beta validates human importin beta as a cell cycle negative regulator. BMC Cell Biol. 2008 Mar 22; 9:14. PMID: 18366719; PMCID: PMC2324082.
      13. Brown CR, Kennedy CJ, Delmar VA, Forbes D, Silver PA. Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. Genes Dev. 2008 Mar 01; 22(5):627-39. PMID: 18316479; PMCID: PMC2259032.
      14. Resendes KK, Rasala BA, Forbes D. Centrin 2 localizes to the vertebrate nuclear pore and plays a role in mRNA and protein export. Mol Cell Biol. 2008 Mar; 28(5):1755-69. PMID: 18172010; PMCID: PMC2258798.
      15. Rasala BA, Orjalo AV, Shen Z, Briggs S, Forbes D. ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17801-6. PMID: 17098863; PMCID: PMC1635652.
      16. Lau CK, Delmar VA, Forbes D. Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue. Anat Rec A Discov Mol Cell Evol Biol. 2006 Jul; 288(7):681-94. PMID: 16779818; PMCID: PMC3049984.
      17. Orjalo AV, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S, Dasso M, Forbes D. The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. Mol Biol Cell. 2006 Sep; 17(9):3806-18. PMID: 16807356; PMCID: PMC1593160.
      18. Harel A, Forbes D. Importin beta: conducting a much larger cellular symphony. Mol Cell. 2004 Nov 05; 16(3):319-30. PMID: 15525506.
        View in: PubMed
      19. Harel A, Chan RC, Lachish-Zalait A, Zimmerman E, Elbaum M, Forbes D. Importin beta negatively regulates nuclear membrane fusion and nuclear pore complex assembly. Mol Biol Cell. 2003 Nov; 14(11):4387-96. PMID: 14551248; PMCID: PMC266759.
      20. Harel A, Orjalo AV, Vincent T, Lachish-Zalait A, Vasu S, Shah S, Zimmerman E, Elbaum M, Forbes D. Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores. Mol Cell. 2003 Apr; 11(4):853-64. PMID: 12718872.
        View in: PubMed
      21. Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes D. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. J Cell Biol. 2001 Oct 29; 155(3):339-54. PMID: 11684705; PMCID: PMC2150853.
      22. Vasu SK, Forbes D. Nuclear pores and nuclear assembly. Curr Opin Cell Biol. 2001 Jun; 13(3):363-75. PMID: 11343909.
        View in: PubMed
      23. Miller BR, Forbes D. Purification of the vertebrate nuclear pore complex by biochemical criteria. Traffic. 2000 Dec; 1(12):941-51. PMID: 11208084; PMCID: PMC4456041.
      24. Miller BR, Powers M, Park M, Fischer W, Forbes D. Identification of a new vertebrate nucleoporin, Nup188, with the use of a novel organelle trap assay. Mol Biol Cell. 2000 Oct; 11(10):3381-96. PMID: 11029043; PMCID: PMC15000.
      25. Ullman KS, Shah S, Powers MA, Forbes D. The nucleoporin nup153 plays a critical role in multiple types of nuclear export. Mol Biol Cell. 1999 Mar; 10(3):649-64. PMID: 10069809; PMCID: PMC25193.
      26. Shah S, Forbes D. Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitors. Curr Biol. 1998 Dec 17-31; 8(25):1376-86. PMID: 9889100.
        View in: PubMed
      27. Ullman KS, Powers MA, Forbes D. Nuclear export receptors: from importin to exportin. Cell. 1997 Sep 19; 90(6):967-70. PMID: 9323123.
        View in: PubMed
      28. Powers MA, Forbes D, Dahlberg JE, Lund E. The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways. J Cell Biol. 1997 Jan 27; 136(2):241-50. PMID: 9015297; PMCID: PMC2134807.
      29. Macaulay C, Forbes D. Assembly of the nuclear pore: biochemically distinct steps revealed with NEM, GTP gamma S, and BAPTA. J Cell Biol. 1996 Jan; 132(1-2):5-20. PMID: 8567730; PMCID: PMC2120707.
      30. Ullman KS, Forbes D. RNA polymerase III transcription in synthetic nuclei assembled in vitro from defined DNA templates. Mol Cell Biol. 1995 Sep; 15(9):4873-83. PMID: 7651406; PMCID: PMC230733.
      31. Meier E, Miller BR, Forbes D. Nuclear pore complex assembly studied with a biochemical assay for annulate lamellae formation. J Cell Biol. 1995 Jun; 129(6):1459-72. PMID: 7790348; PMCID: PMC2291182.
      32. Powers MA, Macaulay C, Masiarz FR, Forbes D. Reconstituted nuclei depleted of a vertebrate GLFG nuclear pore protein, p97, import but are defective in nuclear growth and replication. J Cell Biol. 1995 Mar; 128(5):721-36. PMID: 7876300; PMCID: PMC2120401.
      33. Macaulay C, Meier E, Forbes D. Differential mitotic phosphorylation of proteins of the nuclear pore complex. J Biol Chem. 1995 Jan 06; 270(1):254-62. PMID: 7814383.
        View in: PubMed
      34. Powers MA, Forbes D. Cytosolic factors in nuclear transport: what's importin? Cell. 1994 Dec 16; 79(6):931-4. PMID: 8001141.
        View in: PubMed
      35. Hartl P, Olson E, Dang T, Forbes D. Nuclear assembly with lambda DNA in fractionated Xenopus egg extracts: an unexpected role for glycogen in formation of a higher order chromatin intermediate. J Cell Biol. 1994 Feb; 124(3):235-48. PMID: 8294509; PMCID: PMC2119932.
      36. Hartl P, Gottesfeld J, Forbes D. Mitotic repression of transcription in vitro. J Cell Biol. 1993 Feb; 120(3):613-24. PMID: 8381119; PMCID: PMC2119533.
      37. Forbes D. Structure and function of the nuclear pore complex. Annu Rev Cell Biol. 1992; 8:495-527. PMID: 1282353.
        View in: PubMed
      38. Finlay DR, Meier E, Bradley P, Horecka J, Forbes D. A complex of nuclear pore proteins required for pore function. J Cell Biol. 1991 Jul; 114(1):169-83. PMID: 2050741; PMCID: PMC2289063.
      39. Finlay DR, Forbes D. Reconstitution of biochemically altered nuclear pores: transport can be eliminated and restored. Cell. 1990 Jan 12; 60(1):17-29. PMID: 2295087.
        View in: PubMed
      40. Finlay DR, Newmeyer DD, Hartl PM, Horecka J, Forbes D. Nuclear transport in vitro. J Cell Sci Suppl. 1989; 11:225-42. PMID: 2613752.
        View in: PubMed
      41. Newmeyer DD, Forbes D. Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation. Cell. 1988 Mar 11; 52(5):641-53. PMID: 3345567.
        View in: PubMed
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