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    Aleem Siddiqui

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0711
    CA La Jolla 92093
    Phone858-822-1750
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      Collapse Research 
      Collapse Research Activities and Funding
      Mechanisms of HBV-Induced Innate Immunity
      NIH/NIAID R01AI125350Jun 23, 2017 - May 31, 2022
      Role: Principal Investigator
      2016 Internatinal Meeting o the Molecular Biology of Hepatitis B Viruses
      NIH/NIAID R13AI124562Jul 19, 2016 - Jun 30, 2017
      Role: Principal Investigator
      Intervention of HBV DNA synthesis and transcription
      NIH/NIAID R21AI105939Sep 6, 2013 - Aug 31, 2015
      Role: Principal Investigator
      Hepatitis C Virus-Induced Liver Pathogenesis
      NIH/NIDDK R01DK083479Sep 30, 2010 - Aug 31, 2014
      Role: Principal Investigator
      Role of Lipids in Hepatitis C Virus Maturation
      NIH/NIAID R01AI085087Dec 1, 2009 - Mar 31, 2019
      Role: Principal Investigator
      Role of Lipids in Hepatitis C Virus Maturation
      NIH/NIAID R56AI085087Dec 1, 2009 - Jul 31, 2015
      Role: Principal Investigator
      Viral Hepatitis C and Lipid Homeostasis
      NIH/NIDDK R01DK077704Apr 1, 2007 - Dec 31, 2017
      Role: Principal Investigator
      Determinants of Liver Injury in Chronic Hepatitis C Virus Infection
      NIH U19AI066313Sep 1, 2005 - Nov 28, 2010
      Role: Co-Investigator
      Hepatitis C Virus NS5a Protein and Oxidative Stress
      NIH/NIDDK R01DK061566Jan 8, 2003 - Dec 31, 2008
      Role: Principal Investigator
      LIVER-SPECIFIC EXPRESSION OF HBV GENES
      NIH/NCI R01CA078769Jan 19, 2000 - Dec 31, 2004
      Role: Principal Investigator
      Comprehensive Biology: Exploiting the Yeast Genome
      NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
      Role: Co-Investigator
      HBV induced Liver Pathogenesis
      NIH/NCI R01CA064415Apr 1, 1996 - Sep 30, 2007
      Role: Principal Investigator
      INDO-US VACCINE ACTION PROGRAM
      NIH/NIAID R03AI031994Sep 15, 1991 - Aug 31, 1994
      Role: Principal Investigator
      HEPATITIS B VIRUS DNA AS COCARCINOGEN IN KAPOSI SARCOMA
      NIH/NIAID U01AI021182Apr 1, 1984 - Mar 31, 1987
      Role: Principal Investigator
      EXPRESSION OF HBV GENES AND HEPATOMA
      NIH/NCI R01CA033135Jul 1, 1982 - Nov 30, 1995
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Syed GH, Khan M, Yang S, Siddiqui A. Hepatitis C Virus Lipoviroparticles Assemble in the Endoplasmic Reticulum (ER) and Bud off from the ER to the Golgi Compartment in COPII Vesicles. J Virol. 2017 Aug 01; 91(15). PMID: 28515296.
        View in: PubMed
      2. Khan M, Syed GH, Kim SJ, Siddiqui A. Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity. PLoS Pathog. 2016 Jun; 12(6):e1005693. PMID: 27348524; PMCID: PMC4922663.
      3. Khan M, Syed GH, Kim SJ, Siddiqui A. Mitochondrial dynamics and viral infections: A close nexus. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt B):2822-33. PMID: 25595529; PMCID: PMC4500740 [Available on 10/01/16].
      4. Till A, Saito R, Merkurjev D, Liu JJ, Syed GH, Kolnik M, Siddiqui A, Glas M, Scheffler B, Ideker T, Subramani S. Evolutionary trends and functional anatomy of the human expanded autophagy network. Autophagy. 2015; 11(9):1652-67. PMID: 26103419; PMCID: PMC4590607.
      5. Soto-Acosta R, Bautista-Carbajal P, Syed GH, Siddiqui A, Del Angel RM. Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus. Antiviral Res. 2014 Sep; 109:132-40. PMID: 25017471.
        View in: PubMed
      6. Kim SJ, Syed GH, Khan M, Chiu WW, Sohail MA, Gish RG, Siddiqui A. Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6413-8. PMID: 24733894; PMCID: PMC4035934.
      7. Syed GH, Tang H, Khan M, Hassanein T, Liu J, Siddiqui A. Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation. J Virol. 2014 Mar; 88(5):2519-29. PMID: 24352472; PMCID: PMC3958050.
      8. Kim SJ, Khan M, Quan J, Till A, Subramani S, Siddiqui A. Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis. PLoS Pathog. 2013; 9(12):e1003722. PMID: 24339771; PMCID: PMC3855539.
      9. Kim SJ, Syed GH, Siddiqui A. Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog. 2013 Mar; 9(3):e1003285. PMID: 23555273; PMCID: PMC3610669.
      10. Bishé B, Syed G, Siddiqui A. Phosphoinositides in the hepatitis C virus life cycle. Viruses. 2012 Oct 19; 4(10):2340-58. PMID: 23202467; PMCID: PMC3497055.
      11. Bishé B, Syed GH, Field SJ, Siddiqui A. Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. J Biol Chem. 2012 Aug 10; 287(33):27637-47. PMID: 22745132; PMCID: PMC3431621.
      12. Syed GH, Siddiqui A. Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus. Hepatology. 2011 Dec; 54(6):1936-46. PMID: 21858850; PMCID: PMC3236615.
      13. Amako Y, Syed GH, Siddiqui A. Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein. J Biol Chem. 2011 Apr 01; 286(13):11265-74. PMID: 21285358; PMCID: PMC3064182.
      14. Syed GH, Amako Y, Siddiqui A. Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol Metab. 2010 Jan; 21(1):33-40. PMID: 19854061; PMCID: PMC2818172.
      15. Amako Y, Sarkeshik A, Hotta H, Yates J, Siddiqui A. Role of oxysterol binding protein in hepatitis C virus infection. J Virol. 2009 Sep; 83(18):9237-46. PMID: 19570870; PMCID: PMC2738263.
      16. Nasimuzzaman M, Waris G, Mikolon D, Stupack DG, Siddiqui A. Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J Virol. 2007 Oct; 81(19):10249-57. PMID: 17626077; PMCID: PMC2045478.
      17. Waris G, Felmlee DJ, Negro F, Siddiqui A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol. 2007 Aug; 81(15):8122-30. PMID: 17507484; PMCID: PMC1951320.
      18. Chen J, Siddiqui A. Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol. 2007 Jun; 81(12):6757-60. PMID: 17428866; PMCID: PMC1900104.
      19. Domitrovich AM, Felmlee DJ, Siddiqui A. Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion. J Biol Chem. 2005 Dec 02; 280(48):39802-8. PMID: 16203724.
        View in: PubMed
      20. Waris G, Tardif KD, Siddiqui A. Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3. Biochem Pharmacol. 2002 Nov 15; 64(10):1425-30. PMID: 12417255.
        View in: PubMed
      21. Tardif KD, Mori K, Siddiqui A. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J Virol. 2002 Aug; 76(15):7453-9. PMID: 12097557; PMCID: PMC136367.
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