Shiri Gur-Cohen

Title(s)Assistant Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Technion Institute, Haifa, IsraelB.A.Molecular Biochemistry
    Technion Institute, Haifa, IsraelM.Sc.Medical Sciences
    Weizmann Institute of Science, Rehovot, IsraelPh.D.Immunology
    Rockefeller University , New York, NYPostdocStem Cell Biology
    Collapse Awards and Honors
    2013The Helen and Martin Kimmel Stem Cell Award for outstanding research
    2016Charles H. Revson Foundation Award for Advancing Women in Science
    2017European Molecular Biology Organization (EMBO) postdoctoral fellowship award
    2018Human Frontier Science Program Organization (HFSP) postdoctoral fellowship award
    2020Robertson Therapeutic Development and the Women & Science Entrepreneurship Award
    2021Young Investigator Award- Tri-Institutional Breakout Award
    2023The V Foundation Scholar for Cancer Research
    2023The Tower Foundation Scholar for Cancer Research
    2024Named the Pew-Stewart Scholar for Cancer Research

    Collapse Overview 

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lymphatics act as a signaling hub to regulate intestinal stem cell activity. Cell Stem Cell. 2022 07 07; 29(7):1067-1082.e18. Niec RE, Chu T, Schernthanner M, Gur-Cohen S, Hidalgo L, Pasolli HA, Luckett KA, Wang Z, Bhalla SR, Cambuli F, Kataru RP, Ganesh K, Mehrara BJ, Pe'er D, Fuchs E. PMID: 35728595; PMCID: PMC9271639.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    2. Enhanced thrombin/PAR1 activity promotes G-CSF- and AMD3100-induced mobilization of hematopoietic stem and progenitor cells via NO upregulation. Leukemia. 2021 11; 35(11):3334-3338. Nevo N, Ordonez-Moreno LA, Gur-Cohen S, Avemaria F, Bhattacharya S, Khatib-Massalha E, Bertagna M, Haddad M, Chakrabarti P, Ruf W, Lapidot T, Kollet O. PMID: 33654208.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Author Correction: Extracellular serine controls epidermal stem cell fate and tumour initiation. Nat Cell Biol. 2020 Nov; 22(11):1396. Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, Novak JSS, Tierney MT, Dela Cruz-Racelis J, Fuchs E, Finley LWS. PMID: 33046885.
      View in: PubMed   Mentions:    Fields:    
    4. Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling. Nat Commun. 2020 07 15; 11(1):3547. Khatib-Massalha E, Bhattacharya S, Massalha H, Biram A, Golan K, Kollet O, Kumari A, Avemaria F, Petrovich-Kopitman E, Gur-Cohen S, Itkin T, Brandenburger I, Spiegel A, Shulman Z, Gerhart-Hines Z, Itzkovitz S, Gunzer M, Offermanns S, Alon R, Ariel A, Lapidot T. PMID: 32669546; PMCID: PMC7363928.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    5. Extracellular serine controls epidermal stem cell fate and tumour initiation. Nat Cell Biol. 2020 07; 22(7):779-790. Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, Novak JSS, Tierney MT, Dela Cruz-Racelis J, Fuchs E, Finley LWS. PMID: 32451440; PMCID: PMC7343604.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    6. NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Nat Cell Biol. 2020 06; 22(6):640-650. Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. PMID: 32393888; PMCID: PMC7367149.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    7. The aging skin microenvironment dictates stem cell behavior. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5339-5350. Ge Y, Miao Y, Gur-Cohen S, Gomez N, Yang H, Nikolova M, Polak L, Hu Y, Verma A, Elemento O, Krueger JG, Fuchs E. PMID: 32094197; PMCID: PMC7071859.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    8. Stem cell-driven lymphatic remodeling coordinates tissue regeneration. Science. 2019 12 06; 366(6470):1218-1225. Gur-Cohen S, Yang H, Baksh SC, Miao Y, Levorse J, Kataru RP, Liu X, de la Cruz-Racelis J, Mehrara BJ, Fuchs E. PMID: 31672914; PMCID: PMC6996853.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    9. PAR1 Expression Predicts Clinical G-CSF CD34+ HSPC Mobilization and Repopulation Potential in Transplanted Patients. Hemasphere. 2019 10; 3(4):e288. Nevo N, Zuckerman T, Gur-Cohen S, Kollet O, Avemaria F, Shpall EJ, Mendt MC, Nagler A, Brenner B, Ben Arush M, Lapidot T. PMID: 31942543; PMCID: PMC6919473.
      View in: PubMed   Mentions: 4  
    10. Stem cells repurpose proliferation to contain a breach in their niche barrier. Elife. 2018 12 06; 7. Lay K, Yuan S, Gur-Cohen S, Miao Y, Han T, Naik S, Pasolli HA, Larsen SB, Fuchs E. PMID: 30520726; PMCID: PMC6324878.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    11. Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance. Cell Stem Cell. 2018 10 04; 23(4):572-585.e7. Golan K, Kumari A, Kollet O, Khatib-Massalha E, Subramaniam MD, Ferreira ZS, Avemaria F, Rzeszotek S, García-García A, Xie S, Flores-Figueroa E, Gur-Cohen S, Itkin T, Ludin-Tal A, Massalha H, Bernshtein B, Ciechanowicz AK, Brandis A, Mehlman T, Bhattacharya S, Bertagna M, Cheng H, Petrovich-Kopitman E, Janus T, Kaushansky N, Cheng T, Sagi I, Ratajczak MZ, Méndez-Ferrer S, Dick JE, Markus RP, Lapidot T. PMID: 30174297.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    12. Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer. Cell Rep. 2018 05 15; 23(7):1962-1976. Stettner N, Rosen C, Bernshtein B, Gur-Cohen S, Frug J, Silberman A, Sarver A, Carmel-Neiderman NN, Eilam R, Biton I, Pevsner-Fischer M, Zmora N, Brandis A, Bahar Halpern K, Mazkereth R, di Bernardo D, Brunetti-Pierri N, Premkumar MH, Dank G, Nagamani SCS, Jung S, Harmelin A, Erez A. PMID: 29768197; PMCID: PMC5976577.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    13. Adhesion Assay for Murine Bone Marrow Hematopoietic Stem Cells. Bio Protoc. 2017 Feb 20; 7(4):e2135. Avci S, Gur-Cohen S, Avemaria F, Lapidot T. PMID: 34458456; PMCID: PMC8376563.
      View in: PubMed   Mentions:
    14. VLA-4 Affinity Assay for Murine Bone Marrow-derived Hematopoietic Stem Cells. Bio Protoc. 2017 Feb 20; 7(4):e2134. Avemaria F, Gur-Cohen S, Avci S, Lapidot T. PMID: 34458455; PMCID: PMC8376570.
      View in: PubMed   Mentions: 1  
    15. Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals. Annu Rev Cell Dev Biol. 2016 10 06; 32:649-675. Ramasamy SK, Kusumbe AP, Itkin T, Gur-Cohen S, Lapidot T, Adams RH. PMID: 27576121.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    16. Vascular Procr+ stem cells: Finding new branches while looking for the roots. Cell Res. 2016 10; 26(10):1071-1072. Gur-Cohen S, Lapidot T. PMID: 27481542; PMCID: PMC5113309.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    17. Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. 2016 Oct 13; 538(7624):274. Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Golan K, Khatib E, Kumari A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T. PMID: 27437586.
      View in: PubMed   Mentions: 2     Fields:    
    18. Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. 2016 Apr 21; 532(7599):323-8. Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T. PMID: 27074509; PMCID: PMC6450701.
      View in: PubMed   Mentions: 362     Fields:    Translation:AnimalsCells
    19. Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med. 2016 Apr; 22(4):446. Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T. PMID: 27050594.
      View in: PubMed   Mentions:    Fields:    
    20. Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling. Ann N Y Acad Sci. 2016 04; 1370(1):65-81. Gur-Cohen S, Kollet O, Graf C, Esmon CT, Ruf W, Lapidot T. PMID: 26928241; PMCID: PMC5193365.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med. 2015 Nov; 21(11):1307-17. Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T. PMID: 26457757; PMCID: PMC4776769.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    22. Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment. Antioxid Redox Signal. 2014 Oct 10; 21(11):1605-19. Ludin A, Gur-Cohen S, Golan K, Kaufmann KB, Itkin T, Medaglia C, Lu XJ, Ledergor G, Kollet O, Lapidot T. PMID: 24762207; PMCID: PMC4175025.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    23. Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal. Curr Opin Hematol. 2013 May; 20(3):237-44. Itkin T, Kaufmann KB, Gur-Cohen S, Ludin A, Lapidot T. PMID: 23567340.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    24. Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nat Immunol. 2012 Nov; 13(11):1072-82. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T. PMID: 22983360.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    25. FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation. Blood. 2012 Aug 30; 120(9):1843-55. Itkin T, Ludin A, Gradus B, Gur-Cohen S, Kalinkovich A, Schajnovitz A, Ovadya Y, Kollet O, Canaani J, Shezen E, Coffin DJ, Enikolopov GN, Berg T, Piacibello W, Hornstein E, Lapidot T. PMID: 22645180.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    26. Quantifying hematopoietic stem and progenitor cell mobilization. Methods Mol Biol. 2012; 904:15-35. Gur-Cohen S, Lapid K, Lapidot T. PMID: 22890919.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. MT1-MMP and RECK: opposite and essential roles in hematopoietic stem and progenitor cell retention and migration. J Mol Med (Berl). 2011 Dec; 89(12):1167-74. Golan K, Vagima Y, Goichberg P, Gur-Cohen S, Lapidot T. PMID: 21842347.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    28. Egress and Mobilization of Hematopoietic Stem and Progenitor Cells: A Dynamic Multi-facet Process. StemBook. 2008. Lapid K, Glait-Santar C, Gur-Cohen S, Canaani J, Kollet O, Lapidot T. View Publication.
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